Page last updated: 2024-12-05

hexadecanesulfonyl fluoride

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

AM 374: a palmitylsulfonyl fluoride; inhibits anandamide amidase; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID3572
CHEMBL ID94809
CHEBI ID43275
SCHEMBL ID1309840
MeSH IDM0188676

Synonyms (26)

Synonym
palmitylsulfonyl fluoride
CHEMBL94809 ,
am 374
ancajyd3fv ,
unii-ancajyd3fv
1-hexadecylsulfonyl fluoride
hexadecanesulfonyl fluoride
CHEBI:43275 ,
hexadecane-1-sulfonyl fluoride
1-hexadecanesulfonyl fluoride
86855-26-7
DB02035
am-374
hexadecylsulfonyl fluoride
SCHEMBL1309840
bdbm50396293
1-hexadecanesulfonylfluoride
DTXSID60235876
syl-374
palmitylsulphonyl fluoride
Q27093123
MS-24477
am374
STARBLD0009356
CS-0103617
HY-125967

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" Clinical trials are now required, but are hindered by a paucity of cannabinoids of suitable bioavailability and therapeutic ratio."( Cannabinoids and pain.
Rice, AS, 2001
)
0.31
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
acyl fluorideA compound consisting of an acyl group bonded to fluorine.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Fatty-acid amide hydrolase 1Rattus norvegicus (Norway rat)IC50 (µMol)0.00970.00051.33138.0000AID1363882; AID703163
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID703163Inhibition of rat histidine tagged FAAH expressed in Escherichia coli by coumarin ester substrate fluorescence assay2012Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
Assay and inhibition of diacylglycerol lipase activity.
AID1363882Inhibition of Sprague-Dawley rat brain FAAH using [14C]anandamide as substrate by liquid scintillation counting method2017Journal of medicinal chemistry, 01-12, Volume: 60, Issue:1
Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors.
AID103809Percent inhibition of compound against Lipoprotein lipase(LPL) at 3h was evaluated2000Bioorganic & medicinal chemistry letters, Dec-18, Volume: 10, Issue:24
Inhibition of lipoprotein lipase by alkanesulfonyl fluorides.
AID703169Inhibition of human DAGLalpha expressed in HEK293T cell membrane using [14C]SAG substrate at 10 uM in detergent free solution by scintillation counting based radio-TLC assay2012Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
Assay and inhibition of diacylglycerol lipase activity.
AID703157Inhibition of mouse DAGLalpha expressed in HEK293T cell membrane using [14C]SAG substrate at 100 nM by scintillation counting based radio-TLC assay2012Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
Assay and inhibition of diacylglycerol lipase activity.
AID703162Inhibition of human N-terminal histidine tagged full length MAGL expressed in Escherichia coli at 10 uM by by coumarin ester substrate fluorescence assay2012Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
Assay and inhibition of diacylglycerol lipase activity.
AID703156Inhibition of mouse DAGLalpha expressed in HEK293T cell membrane using [14C]SAG substrate at 1000 nM by scintillation counting based radio-TLC assay2012Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
Assay and inhibition of diacylglycerol lipase activity.
AID703150Inhibition of porcine pancreatic lipase type 2 at 10 uM by FRET assay2012Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
Assay and inhibition of diacylglycerol lipase activity.
AID703158Inhibition of mouse DAGLalpha expressed in HEK293T cell membrane using [14C]SAG substrate at 10 nM by scintillation counting based radio-TLC assay2012Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
Assay and inhibition of diacylglycerol lipase activity.
AID103808Percent inhibition of compound against Lipoprotein lipase(LPL) at 10 uM was evaluated2000Bioorganic & medicinal chemistry letters, Dec-18, Volume: 10, Issue:24
Inhibition of lipoprotein lipase by alkanesulfonyl fluorides.
AID703165Inhibition of rat histidine tagged FAAH expressed in Escherichia coli at 10 uM by coumarin ester substrate fluorescence assay2012Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
Assay and inhibition of diacylglycerol lipase activity.
AID703155Inhibition of mouse DAGLalpha expressed in HEK293T cell membrane using [14C]SAG substrate at 10000 nM by scintillation counting based radio-TLC assay2012Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
Assay and inhibition of diacylglycerol lipase activity.
AID703152Inhibition of bacterial lipoprotein lipase at 10 uM by FRET assay2012Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
Assay and inhibition of diacylglycerol lipase activity.
AID703171Inhibition of human DAGLalpha expressed in HEK293T cell membrane using [14C]SAG substrate at 10 uM using JZL184 pretreated protein in detergent free solution by FRET assay2012Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
Assay and inhibition of diacylglycerol lipase activity.
AID703154Inhibition of human DAGLalpha expressed in HEK293T cell membrane using [14C]SAG substrate at 10 uM in detergent free solution by FRET assay2012Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
Assay and inhibition of diacylglycerol lipase activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's6 (31.58)18.2507
2000's9 (47.37)29.6817
2010's4 (21.05)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.29

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.29 (24.57)
Research Supply Index3.04 (2.92)
Research Growth Index4.33 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.29)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (10.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]