Compounds > physalin g
Page last updated: 2024-11-13

physalin g

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

physalin G: has immunosuppressive activity; from Physalis angulata; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

physalin G : A physalin with antimalarial activity isolated from Physalis angulata. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
PhysalisgenusA plant genus of the family SOLANACEAE. Members contain physalin and withangulatin.[MeSH]SolanaceaeA plant family of the order SOLANALES, class MAGNOLIOPSIDA. Among the most noted are POTATOES; TOMATOES; CAPSICUM (green and red peppers); TOBACCO; and BELLADONNA.[MeSH]

Cross-References

ID SourceID
PubMed CID56683730
CHEMBL ID1835434
CHEBI ID69020
MeSH IDM0569684

Synonyms (4)

Synonym
physalin g
CHEMBL1835434
chebi:69020 ,
Q27137364
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
antimalarialA drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (5)

ClassDescription
enoneAn alpha,beta-unsaturated ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) in which the C=O function is conjugated to a C=C double bond at the alpha,beta position.
6alpha-hydroxy steroid
lactoneAny cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
organic heteroheptacyclic compound
physalinAny seco-steroid based on a 13,14-seco-16,24-cycloergostane skeleton and its substituted derivatives thereof. These phytochemicals form the major steroidal constituents of Physalis plants and exhibit antimicrobial and antiparasitic activity.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (19)

Assay IDTitleYearJournalArticle
AID1869148Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
AID623329Cytotoxicity against BALB/c mouse splenocytes assessed as [3H]thymidine incorporation after 24 hrs by beta counting2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Antimalarial activity of physalins B, D, F, and G.
AID1171138Antiinflammatory activity in Swiss Webster mouse assessed as reduction in paw edema at 100 mg/kg, ip dosed 40 mins before CFA injection and measured 2 to 6 hrs post CFA stimulus2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Antinociceptive properties of physalins from Physalis angulata.
AID1171135Antiinflammatory activity in Swiss Webster mouse assessed as reduction in hyperalgesia at 100 mg/kg, ip dosed 40 mins before CFA injection and measured 2 to 6 hrs post CFA stimulus2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Antinociceptive properties of physalins from Physalis angulata.
AID1171145Antinociceptive activity in Swiss Webster mouse assessed as increase in reaction time at 100 mg/kg, ip measured after 3 hrs by tail flick test2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Antinociceptive properties of physalins from Physalis angulata.
AID1171125Antinociceptive activity in Swiss Webster mouse assessed as inhibition of formalin-induced early phase pain response at 50 mg/kg, ip dosed 40 mins before formalin injection2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Antinociceptive properties of physalins from Physalis angulata.
AID1869149Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
AID1869152Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-stimulated NO production pretreated with LPS followed by compund addition by Griess reagent based microplate reader assay
AID623330Selectivity index, ratio of LC50 for mouse splenocytes to IC50 for chloroquine-resistant and mefloquine-sensitive Plasmodium falciparum W22011Journal of natural products, Oct-28, Volume: 74, Issue:10
Antimalarial activity of physalins B, D, F, and G.
AID1869147Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
AID623328Antimalarial activity against chloroquine-resistant and mefloquine-sensitive Plasmodium falciparum W2 infected in human O-positive erythrocytes assessed as inhibition of parasite growth by [3H]hypoxanthine incorporation assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Antimalarial activity of physalins B, D, F, and G.
AID1171129CNS toxicity in Swiss Webster mouse assessed as effect on motor performance at 100 mg/kg, ip after 40 mins by rotarod test2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Antinociceptive properties of physalins from Physalis angulata.
AID1869153Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
AID1171147Antinociceptive activity in Swiss Webster mouse assessed as increase in latency time at 100 mg/kg, ip measured after 0.5 to 2 hrs by hot plate test2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Antinociceptive properties of physalins from Physalis angulata.
AID1869146Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
AID1171130CNS toxicity in Swiss Webster mouse assessed as effect on motor performance at 100 mg/kg, ip after 40 mins by open field test2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Antinociceptive properties of physalins from Physalis angulata.
AID1171118Antinociceptive activity in Swiss Webster mouse assessed as inhibition of acetic acid-induced abdominal constrictions at 25 to 100 mg/kg, ip dosed 40 mins before acetic acid injection2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Antinociceptive properties of physalins from Physalis angulata.
AID1171124Antinociceptive activity in Swiss Webster mouse assessed as inhibition of formalin-induced late phase pain response at 50 mg/kg, ip dosed 40 mins before formalin injection2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Antinociceptive properties of physalins from Physalis angulata.
AID1869154Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (75.00)24.3611
2020's2 (25.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.26

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.26 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.56 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.26)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.0610aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
diazepam
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.. diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.		2.1101,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		2.110aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
mefloquine hydrochloride
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol : An organofluorine compound that consists of quinoline bearing trifluoromethyl substituents at positions 2 and 8 as well as a (2-piperidinyl)hydroxymethyl substituent at position 4.		2.0610organofluorine compound;
piperidines;
quinolines;
secondary alcohol
withanolides
Withanolides: Ergostane derivatives of 28 carbons with oxygens at C1, C22, and C26 positions and the side chain cyclized. They are found in WITHANIA plant genus and have cytotoxic and other effects.		2.5220
morphine
Meconium: The thick green-to-black mucilaginous material found in the intestines of a full-term fetus. It consists of secretions of the INTESTINAL GLANDS; BILE PIGMENTS; FATTY ACIDS; AMNIOTIC FLUID; and intrauterine debris. It constitutes the first stools passed by a newborn.		2.110morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		2.0710cysteiniumfundamental metabolite
nsc-287088
[no description available]		2.4820
physalin b
physalin B: has immunosuppressive activity; structure in first source. physalin B : A physalin with antimalarial, antitumour and antimicrobial activities isolated from Physalis angulata.		3.2250enone;
lactone;
organic heteroheptacyclic compound;
physalin		antimalarial;
antimicrobial agent;
antineoplastic agent
phytosterols
Phytosterols: A class of organic compounds known as sterols or STEROIDS derived from plants.. phytosterols : Sterols similar to cholesterol which occur in plants and vary only in carbon side chains and/or presence or absence of a double bond.		2.0710
physalin a
physalin A: an anti-inflammatory agent isolated from Physalis alkekengi var; structure in first source		2.5220physalin
physalin f
physalin F: has immunosuppressive activity; from Physalis angulata L; structure given in first source. physalin F : A physalin with antimalarial and antitumour activities isolated from Physalis angulata.		3.0240enone;
epoxy steroid;
lactone;
physalin		antileishmanial agent;
antimalarial;
antineoplastic agent;
apoptosis inducer;
immunosuppressive agent
physalin d
physalin D: from Physalis alkekengi var. franchetti; structure in first source. physalin D : A physalin with antimalarial and antimycobacterial activities isolated from Physalis angulata.		3.36605alpha-hydroxy steroid;
6beta-hydroxy steroid;
cyclic ether;
enone;
lactone;
organic heteroheptacyclic compound;
physalin		antimalarial;
antimycobacterial drug;
antineoplastic agent
ConditionIndicatedRelationship StrengthStudiesTrials
Parasitemia
The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)		02.0610
Infections, Plasmodium
[description not available]		02.0610
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.		02.0610
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.5720
Anasarca
[description not available]		02.110
Allodynia
[description not available]		02.110
Ache
[description not available]		02.110
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		02.110
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.		02.110
Lung Injury, Acute
[description not available]		02.3110
Acute Lung Injury
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).		02.3110
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0710