Page last updated: 2024-11-12

glyx-13 peptide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

GLYX-13 peptide: a monoclonal antibody-derived peptide that acts as an N-methyl-D-aspartate receptor modulator [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID14539800
CHEMBL ID3544917
SCHEMBL ID1668190
MeSH IDM0494248

Synonyms (38)

Synonym
glyx 13 ,
rapastinel [usan:inn]
rapastinel
glyx-13
117928-94-6
6a1x56b95e ,
l-threoninamide, l-threonyl-l-prolyl-l-prolyl-
glyx-13 peptide
unii-6a1x56b95e
tppt-amide
glyx13
S6907
l-threonyl-l-prolyl-l-prolyl-l-threoninamide
rapastinelum
rapastinel [who-dd]
rapastinel [usan]
rapastinel [inn]
SCHEMBL1668190
AC-32874
AKOS024457610
CHEMBL3544917
HY-16728
CS-5507
(2s)-1-[(2s)-1-[(2s,3r)-2-amino-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]-n-[(2s,3r)-1-amino-3-hydroxy-1-oxobutan-2-yl]pyrrolidine-2-carboxamide
glyx13;rapastinel
EX-A794
(s)-1-(l-threonyl-l-prolyl)-n-((2s,3r)-1-amino-3-hydroxy-1-oxobutan-2-yl)pyrrolidine-2-carboxamide
mfcd12912477
NCGC00485669-01
GIBQQARAXHVEGD-BSOLPCOYSA-N
(s)-n-((2s,3r)-1-amino-3-hydroxy-1-oxobutan-2-yl)-1-((s)-1-((2s,3r)-2-amino-3-hydroxybutanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxamide
rapastinel(glyx-13)
DB11801
Q5513673
thr-pro-pro-thr-nh2
rapastinel (glyx-13)
AS-55920
DTXSID501030481

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" However, it is unknown if rapastinel possesses a better side-effect profile than fast-acting glutamatergic antidepressants, like ketamine, which trigger neurotoxicity in the perinatal rodent cortex and protracted schizophrenia-like alterations."( Rapastinel alleviates the neurotoxic effect induced by NMDA receptor blockade in the early postnatal mouse brain.
Gass, P; Inta, D; Lang, UE; Mallien, A; Pfeiffer, N; Vasilescu, AN, 2021
)
0.62

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51

Dosage Studied

ExcerptRelevanceReference
" Based on the POC study described here, a multiple dose study has been completed which showed sustained therapeutic benefit with repeated dosing of GLYX-13 for more than 6 weeks."( Randomized proof of concept trial of GLYX-13, an N-methyl-D-aspartate receptor glycine site partial agonist, in major depressive disorder nonresponsive to a previous antidepressant agent.
Burch, RM; Macaluso, M; Mehra, DO; Moskal, JR; Preskorn, S; Zammit, G, 2015
)
0.42
" Biweekly dosing with rapastinel sustained this effect for at least 8weeks."( The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus.
Boikess, SR; Burch, RM; Burgdorf, J; Disterhoft, JF; Gross, A; Khan, MA; Kroes, RA; Moskal, JR; Rex, CS; Stanton, PK; Weiss, C; Zhang, XL, 2015
)
0.42
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347159Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (48)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (8.33)29.6817
2010's30 (62.50)24.3611
2020's14 (29.17)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.65

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.65 (24.57)
Research Supply Index3.99 (2.92)
Research Growth Index5.64 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.65)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials4 (8.16%)5.53%
Reviews10 (20.41%)6.00%
Case Studies1 (2.04%)4.05%
Observational0 (0.00%)0.25%
Other34 (69.39%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]