netupitant and Pain

netupitant has been researched along with Pain* in 1 studies

Other Studies

1 other study(ies) available for netupitant and Pain

Article	Year
Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief. Proceedings of the National Academy of Sciences of the United States of America, 2023, 05-30, Volume: 120, Issue:22 The hypothesis that sustained G protein-coupled receptor (GPCR) signaling from endosomes mediates pain is based on studies with endocytosis inhibitors and lipid-conjugated or nanoparticle-encapsulated antagonists targeted to endosomes. GPCR antagonists that reverse sustained endosomal signaling and nociception are needed. However, the criteria for rational design of such compounds are ill-defined. Moreover, the role of natural GPCR variants, which exhibit aberrant signaling and endosomal trafficking, in maintaining pain is unknown. Herein, substance P (SP) was found to evoke clathrin-mediated assembly of endosomal signaling complexes comprising neurokinin 1 receptor (NK Topics: Animals; Aprepitant; Endosomes; Humans; Mice; Pain; Receptors, G-Protein-Coupled; Receptors, Neurokinin-1; Substance P	2023

Article

Year

Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief.

Proceedings of the National Academy of Sciences of the United States of America, 2023, 05-30, Volume: 120, Issue:22

The hypothesis that sustained G protein-coupled receptor (GPCR) signaling from endosomes mediates pain is based on studies with endocytosis inhibitors and lipid-conjugated or nanoparticle-encapsulated antagonists targeted to endosomes. GPCR antagonists that reverse sustained endosomal signaling and nociception are needed. However, the criteria for rational design of such compounds are ill-defined. Moreover, the role of natural GPCR variants, which exhibit aberrant signaling and endosomal trafficking, in maintaining pain is unknown. Herein, substance P (SP) was found to evoke clathrin-mediated assembly of endosomal signaling complexes comprising neurokinin 1 receptor (NK

Topics: Animals; Aprepitant; Endosomes; Humans; Mice; Pain; Receptors, G-Protein-Coupled; Receptors, Neurokinin-1; Substance P

2023