glycine and Pain
glycine has been researched along with Pain in 140 studies
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Since glycinergic neurotransmission plays an important inhibitory role in the processing of sensory and motor information, intrathecal glycine (ITG) administration may be a potential therapy for both pain and movement disorders in patients with complex regional pain syndrome (CRPS)." | 9.14 | Intrathecal glycine for pain and dystonia in complex regional pain syndrome. ( Marinus, J; Munts, AG; Onkenhout, W; Teepe-Twiss, IM; van der Plas, AA; van Gerven, JM; van Hilten, JJ; Voormolen, JH, 2009) |
| "Although the glycine antagonists show anti-hyperalgesic action in animal models of neuropathic pain, GV196771 does not appear to be an effective treatment in subjects with chronic neuropathic pain." | 9.10 | A randomized, double-blind, placebo-controlled trial of a glycine antagonist in neuropathic pain. ( Backonja, MM; Dotson, RM; Dworkin, RH; Galer, BS; Katz, NP; Meisner, PD; Quessy, SN; Rauck, RL; Rowbotham, MC; Wallace, MS, 2002) |
| "Indantadol is an oral and nonselective monoamine oxidase inhibitor and NMDA antagonist that is being developed by Vernalis plc, under license from Chiesi Farmaceutici SpA, for the potential treatment of neuropathic pain." | 8.84 | Indantadol, a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain. ( Coluzzi, F; Mattia, C, 2007) |
| "Glycine receptors (GlyRs) play key roles in the processing of inflammatory pain." | 8.31 | AAV-glycine receptor α3 alleviates CFA-induced inflammatory pain by downregulating ERK phosphorylation and proinflammatory cytokine expression in SD rats. ( Chang, LL; Cheng, KI; Kwan, AL; Tseng, KY; Wang, HC, 2023) |
| " Immunodeficient mice were inoculated intrafemorally with the human breast adenocarcinoma cell line MDA-MB-231, then treated 14days later via mini-osmotic pumps inserted intraperitoneally with sulfasalazine, (S)-4-carboxyphenylglycine, or vehicle." | 7.80 | Inhibition of breast cancer-cell glutamate release with sulfasalazine limits cancer-induced bone pain. ( Seidlitz, EP; Singh, G; Ungard, RG, 2014) |
| "Either the glycine site or the GluN2B subunit of NMDARs participates in the phosphorylation of ERK and CREB induced by bath application of NMDA in brain slices or hindpaw injection of 5% formalin in rats, and these might be fundamental molecular mechanisms underlying pain affect." | 7.78 | Activation of glycine site and GluN2B subunit of NMDA receptors is necessary for ERK/CREB signaling cascade in rostral anterior cingulate cortex in rats: implications for affective pain. ( Cao, H; Ren, WH; Zhang, YQ; Zhao, ZQ; Zhu, MY, 2012) |
| "The inhibitory transmitters GABA and glycine play an important role in modulating pain transmission, both in normal and in pathological situations." | 7.76 | Differential distribution of activated spinal neurons containing glycine and/or GABA and expressing c-fos in acute and chronic pain models. ( Duraku, LS; Holstege, JC; Hossaini, M; Jongen, JLM; Saraç, Ç, 2010) |
| " Glycine or muscimol reduced bicuculline-induced allodynia regardless of the administration site, whereas intrathecal taurine reduced bicuculline-induced allodynia." | 7.76 | Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice. ( Lee, IO; Lim, ES, 2010) |
| " The aim of the present study was to evaluate whether a specific loss of glycinergic neurons is necessary to develop hyperalgesia and allodynia in the chronic constriction injury (CCI) model of neuropathic pain." | 7.75 | Loss of spinal glycinergic neurons is not necessary for development of neuropathic pain in transgenic mice expressing enhanced green fluorescent protein in glycinergic neurons. ( Bauer, I; Braun, S; Hermanns, H; Lipfert, P; Muth-Selbach, U; Werdehausen, R, 2009) |
| "In the present study we examined the effect of NA-glycine in a rat model of inflammatory pain." | 7.74 | Actions of N-arachidonyl-glycine in a rat inflammatory pain model. ( Mitchell, VA; Succar, R; Vaughan, CW, 2007) |
| "An increase in endogenous glycine via glycine transporter 1 blockade not only results in a net inhibitory influence on pain transmission at the spinal level but also supraspinally relieves decreased synaptic efficacy presumably related to cognitive disturbance often described in patients with chronic pain." | 7.74 | Glycine transporter inhibitors as a potential therapeutic strategy for chronic pain with memory impairment. ( Kodama, D; Ono, H; Takasu, K; Tanabe, M; Yamaguchi, S, 2008) |
| "Here, we have examined the effect of the novel antinociceptive agent CHF3381 on the development of nocifensive behaviour as well as secondary mechanical allodynia and hyperalgesia induced by intraplantar injection of capsaicin in rats." | 7.73 | CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats. ( Bassani, F; Bergamaschi, M; Tonino Bolzoni, P; Villetti, G, 2005) |
| " In this study, we tested the hypothesis that removal of GABAergic and glycinergic inhibitory inputs attenuates the effect of morphine on dorsal horn projection neurons and the reduced spinal GABAergic tone contributes to attenuated morphine effect in neuropathic pain." | 7.73 | Effect of morphine on deep dorsal horn projection neurons depends on spinal GABAergic and glycinergic tone: implications for reduced opioid effect in neuropathic pain. ( Chen, SR; Chen, YP; Pan, HL, 2005) |
| "Neuropathic pain has been postulated to be mediated, in part, by amino acid neurotransmitters including glycine." | 7.70 | Long-term intrathecal administration of glycine prevents mechanical hyperalgesia in a rat model of neuropathic pain. ( Huang, W; Simpson, RK, 2000) |
| " We recently showed that intrathecal administration of nociceptin induced allodynia by innocuous tactile stimuli and hyperalgesia by noxious thermal stimuli in conscious mice." | 7.69 | Inhibition of nociceptin-induced allodynia in conscious mice by prostaglandin D2. ( Ito, S; Minami, T; Mori, H; Nishizawa, M; Okuda-Ashitaka, E, 1997) |
| "Tranexamic acid (TXA) is an antifibrinolytic agent widely used to reduce blood loss during surgery." | 5.42 | Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn. ( Baba, H; Kamiya, Y; Kohno, T; Ohashi, M; Ohashi, N; Sasaki, M, 2015) |
| "Hydrogen sulfide (H2S) is a gasotransmitter endogenously generated from the metabolism of L-cysteine by action of two main enzymes called cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE)." | 5.39 | Role of hydrogen sulfide in the pain processing of non-diabetic and diabetic rats. ( Araiza-Saldaña, CI; Barragán-Iglesias, P; Flores-Murrieta, FJ; Godínez-Chaparro, B; Navarrete, A; Roa-Coria, JE; Rocha-González, HI; Torres-López, JE; Velasco-Xolalpa, ME, 2013) |
| "Since glycinergic neurotransmission plays an important inhibitory role in the processing of sensory and motor information, intrathecal glycine (ITG) administration may be a potential therapy for both pain and movement disorders in patients with complex regional pain syndrome (CRPS)." | 5.14 | Intrathecal glycine for pain and dystonia in complex regional pain syndrome. ( Marinus, J; Munts, AG; Onkenhout, W; Teepe-Twiss, IM; van der Plas, AA; van Gerven, JM; van Hilten, JJ; Voormolen, JH, 2009) |
| " The analgesic activity of CHF3381 was investigated in the heat-capsaicin human pain model and compared with those of gabapentin." | 5.12 | CHF3381, a N-methyl-D-aspartate receptor antagonist and monoamine oxidase-A inhibitor, attenuates secondary hyperalgesia in a human pain model. ( Dahl, JB; Fabbri, L; Hilsted, KL; Imbimbo, BP; Mathiesen, O, 2006) |
| "Although the glycine antagonists show anti-hyperalgesic action in animal models of neuropathic pain, GV196771 does not appear to be an effective treatment in subjects with chronic neuropathic pain." | 5.10 | A randomized, double-blind, placebo-controlled trial of a glycine antagonist in neuropathic pain. ( Backonja, MM; Dotson, RM; Dworkin, RH; Galer, BS; Katz, NP; Meisner, PD; Quessy, SN; Rauck, RL; Rowbotham, MC; Wallace, MS, 2002) |
| " We therefore investigated the effects of a commercially available artificial sweetener (10 parts cyclamate and 1 part saccharin), glycine (sweet amino acid) or breast milk in reducing reaction to pain as compared with a placebo." | 5.09 | Artificial sweetener reduces nociceptive reaction in term newborn infants. ( Baumgartner, R; Bucher, HU; Bucher, N; Fauchère, JC; Seiler, M, 2000) |
| "Indantadol is an oral and nonselective monoamine oxidase inhibitor and NMDA antagonist that is being developed by Vernalis plc, under license from Chiesi Farmaceutici SpA, for the potential treatment of neuropathic pain." | 4.84 | Indantadol, a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain. ( Coluzzi, F; Mattia, C, 2007) |
| "Glycine receptors (GlyRs) play key roles in the processing of inflammatory pain." | 4.31 | AAV-glycine receptor α3 alleviates CFA-induced inflammatory pain by downregulating ERK phosphorylation and proinflammatory cytokine expression in SD rats. ( Chang, LL; Cheng, KI; Kwan, AL; Tseng, KY; Wang, HC, 2023) |
| "The endogenous lipids N-arachidonylglycine and oleoyl-l-carnitine are potential therapeutic leads in the treatment of chronic pain through their inhibition of the glycine transporter GlyT2." | 3.91 | Lipid-Based Inhibitors Act Directly on GlyT2. ( O'Mara, ML; Schumann-Gillett, A, 2019) |
| " Immunodeficient mice were inoculated intrafemorally with the human breast adenocarcinoma cell line MDA-MB-231, then treated 14days later via mini-osmotic pumps inserted intraperitoneally with sulfasalazine, (S)-4-carboxyphenylglycine, or vehicle." | 3.80 | Inhibition of breast cancer-cell glutamate release with sulfasalazine limits cancer-induced bone pain. ( Seidlitz, EP; Singh, G; Ungard, RG, 2014) |
| "Either the glycine site or the GluN2B subunit of NMDARs participates in the phosphorylation of ERK and CREB induced by bath application of NMDA in brain slices or hindpaw injection of 5% formalin in rats, and these might be fundamental molecular mechanisms underlying pain affect." | 3.78 | Activation of glycine site and GluN2B subunit of NMDA receptors is necessary for ERK/CREB signaling cascade in rostral anterior cingulate cortex in rats: implications for affective pain. ( Cao, H; Ren, WH; Zhang, YQ; Zhao, ZQ; Zhu, MY, 2012) |
| " Glycine or muscimol reduced bicuculline-induced allodynia regardless of the administration site, whereas intrathecal taurine reduced bicuculline-induced allodynia." | 3.76 | Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice. ( Lee, IO; Lim, ES, 2010) |
| "Isovaline reduced responses in mouse pain models without producing acute toxicity, possibly by enhancing receptor modulation of nociceptive information." | 3.76 | Analgesic properties of the novel amino acid, isovaline. ( Chung, CC; MacLeod, BA; Puil, E; Ries, CR; Schwarz, SK; Wang, JT, 2010) |
| "The inhibitory transmitters GABA and glycine play an important role in modulating pain transmission, both in normal and in pathological situations." | 3.76 | Differential distribution of activated spinal neurons containing glycine and/or GABA and expressing c-fos in acute and chronic pain models. ( Duraku, LS; Holstege, JC; Hossaini, M; Jongen, JLM; Saraç, Ç, 2010) |
| " The effects on the pain threshold index in hot-plate test and the writhing times in acetic acid-induced writhing test were observed." | 3.75 | Intracerebroventricular or intrathecal injection of glycine produces analgesia in thermal nociception and chemical nociception via glycine receptors. ( Chen, HS; Cheng, MY; Cheng, W; Feng, T; Liu, GJ; Wang, S; Yin, Q; Zeng, YM, 2009) |
| " Whether glycinergic mechanisms, which play a pivotal role in pain modulation, are involved in lidocaine-induced antinociception is hitherto unclear." | 3.75 | Antinociceptive effects of systemic lidocaine: involvement of the spinal glycinergic system. ( Bauer, I; Freynhagen, R; Hermanns, H; Kollosche, K; Lipfert, P; Muth-Selbach, U; Stegmann, JU, 2009) |
| " The aim of the present study was to evaluate whether a specific loss of glycinergic neurons is necessary to develop hyperalgesia and allodynia in the chronic constriction injury (CCI) model of neuropathic pain." | 3.75 | Loss of spinal glycinergic neurons is not necessary for development of neuropathic pain in transgenic mice expressing enhanced green fluorescent protein in glycinergic neurons. ( Bauer, I; Braun, S; Hermanns, H; Lipfert, P; Muth-Selbach, U; Werdehausen, R, 2009) |
| " N-Arachidonylglycine (NAGly) is an endogenous inhibitor of GLYT2 with little or no effect on GLYT1 and is analgesic in rat models of neuropathic and inflammatory pain." | 3.75 | Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport. ( Edington, AR; Kassiou, M; McKinzie, AA; Reynolds, AJ; Ryan, RM; Vandenberg, RJ, 2009) |
| "The rare amino acid isovaline has analgesic properties in pain models and is a structural analogue of the inhibitory neurotransmitter glycine." | 3.75 | Isovaline causes inhibition by increasing potassium conductance in thalamic neurons. ( Cooke, JE; Mathers, DA; Puil, E, 2009) |
| "In this study, the effect of (S)-3,4-dicarboxyphenylglycine (DCPG), a selective mGlu8 receptor agonist, has been investigated in inflammatory and neuropathic pain models in order to elucidate the role of mGlu8 receptor in modulating pain perception." | 3.74 | Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. ( de Novellis, V; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Scafuro, MA; Vita, D, 2007) |
| "In the present study we examined the effect of NA-glycine in a rat model of inflammatory pain." | 3.74 | Actions of N-arachidonyl-glycine in a rat inflammatory pain model. ( Mitchell, VA; Succar, R; Vaughan, CW, 2007) |
| " This efficient route enabled to scale up the synthesis of an orally bioavailable glycine antagonist showing outstanding in vivo anti-hyperalgesic activity in different animal models of sustained inflammation and chronic neuropathic pain." | 3.74 | Chiral tetrahydroquinoline derivatives as potent anti-hyperalgesic agents in animal models of sustained inflammation and chronic neuropathic pain. ( Alvaro, G; Barnaby, RJ; Bertani, B; Corsi, M; Di Fabio, R; Donati, D; Gentile, G; Giacobbe, S; Pentassuglia, G; Pizzi, DM; Quartaroli, M; Ratti, E; Spada, S; Vitulli, G, 2007) |
| "The present study investigated the hypothesis that hydrogen sulfide (H2S) is pro-nociceptive in the formalin model of persistent inflammatory pain in the adult rat." | 3.74 | A nociceptive-intensity-dependent role for hydrogen sulphide in the formalin model of persistent inflammatory pain. ( Cheng, Y; Khanna, S; Lee, AT; Li, L; Moore, PK; Shah, JJ, 2008) |
| "An increase in endogenous glycine via glycine transporter 1 blockade not only results in a net inhibitory influence on pain transmission at the spinal level but also supraspinally relieves decreased synaptic efficacy presumably related to cognitive disturbance often described in patients with chronic pain." | 3.74 | Glycine transporter inhibitors as a potential therapeutic strategy for chronic pain with memory impairment. ( Kodama, D; Ono, H; Takasu, K; Tanabe, M; Yamaguchi, S, 2008) |
| "Here, we have examined the effect of the novel antinociceptive agent CHF3381 on the development of nocifensive behaviour as well as secondary mechanical allodynia and hyperalgesia induced by intraplantar injection of capsaicin in rats." | 3.73 | CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats. ( Bassani, F; Bergamaschi, M; Tonino Bolzoni, P; Villetti, G, 2005) |
| " In this study, we tested the hypothesis that removal of GABAergic and glycinergic inhibitory inputs attenuates the effect of morphine on dorsal horn projection neurons and the reduced spinal GABAergic tone contributes to attenuated morphine effect in neuropathic pain." | 3.73 | Effect of morphine on deep dorsal horn projection neurons depends on spinal GABAergic and glycinergic tone: implications for reduced opioid effect in neuropathic pain. ( Chen, SR; Chen, YP; Pan, HL, 2005) |
| " We show that the conjugate of arachidonic acid and glycine (N-arachidonylglycine (NAGly)) is present in bovine and rat brain as well as other tissues and that it suppresses tonic inflammatory pain." | 3.71 | Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. ( Bisogno, T; Burstein, S; Chang, SY; Coop, A; De Petrocellis, L; Di Marzo, V; Huang, SM; Maeda, DY; Petros, TJ; Sivakumar, R; Walker, JM; Zavitsanos, PA; Zipkin, RE, 2001) |
| "Changes in the inhibitory activity mediated by gamma-aminobutyric acid (GABA) and glycine, acting at spinal GABAA receptors and strychnine-sensitive glycine receptors, are of interest in the development of neuropathic pain." | 3.71 | Electrophysiologic evidence for increased endogenous gabaergic but not glycinergic inhibitory tone in the rat spinal nerve ligation model of neuropathy. ( Basu, A; Dickenson, AH; Kontinen, VK; Stanfa, LC, 2001) |
| " This study examined the effects of the metabotropic glutamate receptor agonists (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3R)-ACPD), (S)-3,5-dihydroxyphenylglycine ((S)-3,5-DHPG) and (1S,3S)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3S)-ACPD) on the electrically evoked responses of dorsal horn neurones recorded in normal animals and in animals 3 h after the induction of carrageenan inflammation." | 3.70 | Inflammation alters the effects of mGlu receptor agonists on spinal nociceptive neurones. ( Dickenson, AH; Stanfa, LC, 1998) |
| "Neuropathic pain has been postulated to be mediated, in part, by amino acid neurotransmitters including glycine." | 3.70 | Long-term intrathecal administration of glycine prevents mechanical hyperalgesia in a rat model of neuropathic pain. ( Huang, W; Simpson, RK, 2000) |
| " We evaluated the ability of the functional antagonist at the glycine site of the N-methyl-D-aspartate (NMDA) receptor complex, (+)-(1-Hydroxy-3-aminopyrrolodine-2-one) ((+)-HA966), to modulate the antinociceptive action of systemic morphine in a rat model of neuropathic pain produced by chronic constriction injury to the sciatic nerve." | 3.70 | The antinociceptive effect of combined systemic administration of morphine and the glycine/NMDA receptor antagonist, (+)-HA966 in a rat model of peripheral neuropathy. ( Christensen, D; Guilbaud, G; Idänpään-Heikkilä, JJ; Kayser, V, 1998) |
| " We recently showed that intrathecal administration of nociceptin induced allodynia by innocuous tactile stimuli and hyperalgesia by noxious thermal stimuli in conscious mice." | 3.69 | Inhibition of nociceptin-induced allodynia in conscious mice by prostaglandin D2. ( Ito, S; Minami, T; Mori, H; Nishizawa, M; Okuda-Ashitaka, E, 1997) |
| "A twice daily regimen of CHF3381 appears to be adequate from a pharmacokinetic and pharmacodynamic perspective." | 2.71 | Steady-state pharmacokinetics and pharmacodynamics of CHF3381, a novel antineuropathic pain agent, in healthy subjects. ( Astruc, B; Dostert, P; Fabbri, L; Imbimbo, BP; Mariotti, F; Tarral, A, 2005) |
| "The PTX-induced thermal hyperalgesia peaked between day 2 and 4, but no cold allodynia is observed; i." | 2.42 | Implications of intrathecal pertussis toxin animal model on the cellular mechanisms of neuropathic pain syndrome. ( Chang, YC; Wen, ZH; Wong, CS, 2003) |
| "Tranexamic acid (TXA) is an antifibrinolytic agent widely used to reduce blood loss during surgery." | 1.42 | Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn. ( Baba, H; Kamiya, Y; Kohno, T; Ohashi, M; Ohashi, N; Sasaki, M, 2015) |
| "Hydrogen sulfide (H2S) is a gasotransmitter endogenously generated from the metabolism of L-cysteine by action of two main enzymes called cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE)." | 1.39 | Role of hydrogen sulfide in the pain processing of non-diabetic and diabetic rats. ( Araiza-Saldaña, CI; Barragán-Iglesias, P; Flores-Murrieta, FJ; Godínez-Chaparro, B; Navarrete, A; Roa-Coria, JE; Rocha-González, HI; Torres-López, JE; Velasco-Xolalpa, ME, 2013) |
| "Using pharmacological approaches and siRNA-mediated protein knockdown methodology, we elucidate the molecular mechanisms of GLYT regulation." | 1.37 | P2Y purinergic regulation of the glycine neurotransmitter transporters. ( Aragón, C; Delicado, EG; Jiménez, E; López-Corcuera, B; Miras-Portugal, MT; Pérez-Sen, R; Zafra, F, 2011) |
| "Hyperalgesia was assessed in mice using the tail immersion test." | 1.35 | mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo. ( Carroll, FI; Dewey, WL; Gabra, BH; Navarro, HA; Smith, FL, 2008) |
| "Glycine is an important inhibitory neurotransmitter in the spinal cord, but it also acts as a coagonist at the glycine site of N-methyl-d-aspartate (NMDA) receptors to potentiate nociceptive transmission." | 1.35 | Increased C-fiber nociceptive input potentiates inhibitory glycinergic transmission in the spinal dorsal horn. ( Chen, SR; Pan, HL; Zhang, HM; Zhou, HY, 2008) |
| " Unlike morphine, CHF3381 chronic administration was not accompanied by the development of tolerance in the formalin test." | 1.32 | Antinociceptive activity of the N-methyl-D-aspartate receptor antagonist N-(2-Indanyl)-glycinamide hydrochloride (CHF3381) in experimental models of inflammatory and neuropathic pain. ( Barbieri, M; Bassani, F; Bergamaschi, M; Bolzoni, PT; Chamiot-Clerc, P; Maiorino, M; Pietra, C; Rondelli, I; Simonato, M; Villetti, G, 2003) |
| " Taken together, the data suggest that acute and chronic administration of ACEA-1328 differentially affected the antinociceptive effect of U50,488H." | 1.30 | Effects of ACEA-1328, a NMDA receptor/glycine site antagonist, on U50,488H-induced antinociception and tolerance. ( Doan, P; Lutfy, K; Nguyen, M; Weber, E, 1999) |
| " The ability of intrathecal glycine and the glycine derivative betaine to reverse strychnine-induced allodynia was also determined using dose-response analysis." | 1.29 | Strychnine-dependent allodynia in the urethane-anesthetized rat is segmentally distributed and prevented by intrathecal glycine and betaine. ( Loomis, CW; Sherman, SE, 1995) |
| "Strychnine induced two types of motor seizures: (1) falling over with tail whipping and (2) convulsions." | 1.27 | Prevention of the convulsant and hyperalgesic action of strychnine by intrathecal glycine and related amino acids. ( Banas, C; Beyer, C; Gomora, P; Komisaruk, BR, 1988) |
| "Skin hyperalgesia persisted for at least 30 minutes in both strychnine and glycine treated rats." | 1.27 | Hyperalgesia induced by altered glycinergic activity at the spinal cord. ( Beyer, C; Komisaruk, BR; Roberts, LA, 1985) |
Research
Studies (140)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (8.57) | 18.7374 |
| 1990's | 20 (14.29) | 18.2507 |
| 2000's | 73 (52.14) | 29.6817 |
| 2010's | 32 (22.86) | 24.3611 |
| 2020's | 3 (2.14) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Kang, G | 1 |
| Zhao, M | 1 |
| Zhang, X | 1 |
| Peng, L | 1 |
| Li, C | 1 |
| Mao, W | 1 |
| Ye, W | 1 |
| Peng, S | 1 |
| Wang, HC | 1 |
| Cheng, KI | 1 |
| Tseng, KY | 1 |
| Kwan, AL | 1 |
| Chang, LL | 1 |
| Le, HTN | 1 |
| Rijal, S | 1 |
| Jang, SH | 1 |
| Park, SA | 1 |
| Park, SJ | 1 |
| Jung, W | 1 |
| Han, SK | 1 |
| Garattini, EG | 1 |
| Santos, BM | 1 |
| Ferrari, DP | 1 |
| Capel, CP | 1 |
| Francescato, HDC | 1 |
| Coimbra, TM | 1 |
| Leite-Panissi, CRA | 1 |
| Branco, LGS | 1 |
| Nascimento, GC | 1 |
| Breitinger, U | 1 |
| Breitinger, HG | 1 |
| Honda, K | 2 |
| Shinoda, M | 2 |
| Kondo, M | 1 |
| Shimizu, K | 1 |
| Yonemoto, H | 1 |
| Otsuki, K | 1 |
| Akasaka, R | 1 |
| Furukawa, A | 2 |
| Iwata, K | 2 |
| Villarejo-López, L | 1 |
| Jiménez, E | 2 |
| Bartolomé-Martín, D | 1 |
| Zafra, F | 2 |
| Lapunzina, P | 1 |
| Aragón, C | 2 |
| López-Corcuera, B | 2 |
| Jiang, YM | 1 |
| Sun, DD | 1 |
| Wang, ZG | 1 |
| Li, T | 1 |
| Zhao, XL | 1 |
| Jiao, Y | 1 |
| Liu, Y | 1 |
| Li, YJ | 1 |
| Ouyang, JF | 1 |
| Wang, DQ | 1 |
| Schumann-Gillett, A | 1 |
| O'Mara, ML | 1 |
| Velasco-Xolalpa, ME | 1 |
| Barragán-Iglesias, P | 1 |
| Roa-Coria, JE | 1 |
| Godínez-Chaparro, B | 1 |
| Flores-Murrieta, FJ | 1 |
| Torres-López, JE | 1 |
| Araiza-Saldaña, CI | 1 |
| Navarrete, A | 1 |
| Rocha-González, HI | 1 |
| Ungard, RG | 1 |
| Seidlitz, EP | 1 |
| Singh, G | 1 |
| Harvey, RJ | 3 |
| Yee, BK | 1 |
| Dhaneshwar, S | 1 |
| Kusurkar, M | 1 |
| Bodhankar, S | 1 |
| Bihani, G | 1 |
| Luz, LL | 1 |
| Szucs, P | 1 |
| Safronov, BV | 1 |
| Palazzo, E | 5 |
| de Novellis, V | 4 |
| Rossi, F | 4 |
| Maione, S | 5 |
| Koltyn, KF | 1 |
| Brellenthin, AG | 1 |
| Cook, DB | 1 |
| Sehgal, N | 1 |
| Hillard, C | 1 |
| Foster, E | 1 |
| Wildner, H | 2 |
| Tudeau, L | 1 |
| Haueter, S | 1 |
| Ralvenius, WT | 1 |
| Jegen, M | 1 |
| Johannssen, H | 1 |
| Hösli, L | 1 |
| Haenraets, K | 1 |
| Ghanem, A | 1 |
| Conzelmann, KK | 1 |
| Bösl, M | 1 |
| Zeilhofer, HU | 7 |
| Ohashi, N | 1 |
| Sasaki, M | 1 |
| Ohashi, M | 1 |
| Kamiya, Y | 1 |
| Baba, H | 1 |
| Kohno, T | 1 |
| Fu, Y | 1 |
| Ji, G | 3 |
| Neugebauer, V | 3 |
| Palmer, JA | 1 |
| Higuera, ES | 1 |
| Chang, L | 1 |
| Chaplan, SR | 1 |
| Jiang, P | 1 |
| Kong, Y | 1 |
| Zhang, XB | 1 |
| Wang, W | 2 |
| Liu, CF | 1 |
| Xu, TL | 1 |
| Hermanns, H | 2 |
| Muth-Selbach, U | 3 |
| Lipfert, P | 3 |
| Braun, S | 1 |
| Werdehausen, R | 1 |
| Bauer, I | 2 |
| Stegmann, JU | 2 |
| Kollosche, K | 2 |
| Freynhagen, R | 1 |
| Radhakrishnan, R | 1 |
| Sluka, KA | 1 |
| Cheng, W | 1 |
| Yin, Q | 1 |
| Cheng, MY | 1 |
| Chen, HS | 1 |
| Wang, S | 1 |
| Feng, T | 1 |
| Zeng, YM | 1 |
| Liu, GJ | 1 |
| Munts, AG | 1 |
| van der Plas, AA | 1 |
| Voormolen, JH | 1 |
| Marinus, J | 1 |
| Teepe-Twiss, IM | 1 |
| Onkenhout, W | 1 |
| van Gerven, JM | 1 |
| van Hilten, JJ | 1 |
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Clinical Trials (3)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intrathecal Immunoglobulin for Treatment of Adult Patients With Tetanus: a Randomized Controlled 2x2 Factorial Trial[NCT02999815] | Phase 1/Phase 2 | 272 participants (Actual) | Interventional | 2017-02-13 | Completed | ||
| A Randomized Controlled Phase II, Two-Arm Study of Umbilical Cord Blood Cell Transplant (MC001) Into Injured Spinal Cord Followed by the Locomotor Training for Patients With Chronic Complete Spinal Cord Injuries (SCI).[NCT03979742] | Phase 2 | 18 participants (Anticipated) | Interventional | 2022-02-22 | Recruiting | ||
| Phenomics and Genomics of Clinically Relevant Chronic Postsurgical Pain: A Multicenter Prospective Study[NCT04798573] | 10,000 participants (Anticipated) | Observational | 2012-08-03 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
12 reviews available for glycine and Pain
| Article | Year |
|---|---|
Modulators of the Inhibitory Glycine Receptor.
Topics: Analgesics; Glycine; Humans; Pain; Receptors, Glycine; Synaptic Transmission | 2020 |
Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain.
Topics: Alcoholism; Animals; Drugs, Investigational; Glycine; Glycine Plasma Membrane Transport Proteins; Hu | 2013 |
Supraspinal metabotropic glutamate receptor subtype 8: a switch to turn off pain.
Topics: Animals; Benzoates; Female; Glycine; Humans; Male; Mice, Knockout; Neuroglia; Neurons; Pain; Recepto | 2014 |
Fast synaptic inhibition in spinal sensory processing and pain control.
Topics: Animals; gamma-Aminobutyric Acid; Glycine; Humans; Interneurons; Neurotransmitter Agents; Pain; Post | 2012 |
Advances in pain therapeutics.
Topics: Anesthetics, Local; Animals; Binding Sites; Glycine; Humans; Molecular Structure; NAV1.9 Voltage-Gat | 2003 |
CHF 3381.
Topics: Animals; Drugs, Investigational; Glycine; Humans; Indans; Monoamine Oxidase Inhibitors; Pain | 2004 |
Implications of intrathecal pertussis toxin animal model on the cellular mechanisms of neuropathic pain syndrome.
Topics: Animals; Disease Models, Animal; Excitatory Amino Acids; Glycine; Hyperalgesia; Injections, Spinal; | 2003 |
Role of cation-chloride-cotransporters (CCC) in pain and hyperalgesia.
Topics: Analgesics; gamma-Aminobutyric Acid; Glycine; Hyperalgesia; K Cl- Cotransporters; Pain; Posterior Ho | 2005 |
Development of pain: maturation of spinal inhibitory networks.
Topics: Animals; gamma-Aminobutyric Acid; Glycine; Humans; Inhibitory Postsynaptic Potentials; Nerve Net; Pa | 2007 |
N-methyl-D-aspartate antagonists and neuropathic pain: the search for relief.
Topics: Analgesics; Analgesics, Opioid; Animals; Binding Sites; Glycine; Humans; Ion Channel Gating; Pain; P | 2007 |
Indantadol, a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain.
Topics: Analgesics; Animals; Anticonvulsants; Clinical Trials as Topic; Diabetic Neuropathies; Glycine; Huma | 2007 |
Loss of glycinergic and GABAergic inhibition in chronic pain--contributions of inflammation and microglia.
Topics: Animals; Chronic Disease; Dinoprostone; gamma-Aminobutyric Acid; Glycine; Humans; Inflammation; Micr | 2008 |
Trials
7 trials available for glycine and Pain
| Article | Year |
|---|---|
Intrathecal glycine for pain and dystonia in complex regional pain syndrome.
Topics: Adult; Complex Regional Pain Syndromes; Cross-Over Studies; Double-Blind Method; Dystonia; Female; G | 2009 |
A randomized, double-blind, placebo-controlled trial of a glycine antagonist in neuropathic pain.
Topics: Adult; Aged; Aged, 80 and over; Double-Blind Method; Female; Glycine; Glycine Agents; Hot Temperatur | 2002 |
Steady-state pharmacokinetics and pharmacodynamics of CHF3381, a novel antineuropathic pain agent, in healthy subjects.
Topics: Administration, Oral; Adolescent; Adult; Analgesics; Area Under Curve; Attention; Central Nervous Sy | 2005 |
CHF3381, a N-methyl-D-aspartate receptor antagonist and monoamine oxidase-A inhibitor, attenuates secondary hyperalgesia in a human pain model.
Topics: Adult; Amines; Analgesics; Capsaicin; Cross-Over Studies; Cyclohexanecarboxylic Acids; Double-Blind | 2006 |
The effect of arginine or glycine supplementation on gastrointestinal function, muscle injury, serum amino acid concentrations and performance during a marathon run.
Topics: Adult; Amino Acids; Arginine; Dietary Supplements; Female; Gastrointestinal Hemorrhage; Glycine; Hum | 1999 |
Artificial sweetener reduces nociceptive reaction in term newborn infants.
Topics: Analgesics; Crying; Cyclamates; Female; Glycine; Heart Rate; Humans; Infant, Newborn; Male; Milk, Hu | 2000 |
[First results of the clinical use of injectable lysine acetylsalicylate].
Topics: Adult; Aged; Analgesics; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Combinations | 1972 |
Other Studies
121 other studies available for glycine and Pain
| Article | Year |
|---|---|
A class of novel conjugates of substituted purine and Gly-AA-OBzl: synthesis and evaluation of orally analgesic activity.
Topics: Administration, Oral; Analgesics; Animals; Chronic Disease; Glycine; Humans; Male; Mice; Pain; Purin | 2010 |
AAV-glycine receptor α3 alleviates CFA-induced inflammatory pain by downregulating ERK phosphorylation and proinflammatory cytokine expression in SD rats.
Topics: Animals; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Freund's Adjuvant; Glycine; Human | 2023 |
Inhibitory Effects of Honokiol on Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis in Juvenile Mice.
Topics: Animals; Glycine; Humans; Mice; Neurons; Neurotransmitter Agents; Pain; Receptors, GABA-A; Substanti | 2023 |
Propargylglycine decreases neuro-immune interaction inducing pain response in temporomandibular joint inflammation model.
Topics: Alkynes; Animals; Cystathionine gamma-Lyase; Enzyme Inhibitors; Glycine; Hydrogen Sulfide; Hyperalge | 2019 |
Sensitization of TRPV1 and TRPA1 via peripheral mGluR5 signaling contributes to thermal and mechanical hypersensitivity.
Topics: Acetanilides; Animals; Disease Models, Animal; Enzyme Inhibitors; Freund's Adjuvant; Glutamic Acid; | 2017 |
P2X receptors up-regulate the cell-surface expression of the neuronal glycine transporter GlyT2.
Topics: Adenosine Triphosphate; Animals; Brain Stem; Cell Membrane; Cells, Cultured; Cerebral Cortex; Gangli | 2017 |
[Analgesic effect and central mechanisms of CQ prescription on cancer invasion induced mirror image pain in model mice].
Topics: Analgesics; Animals; Drugs, Chinese Herbal; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Male; M | 2017 |
Lipid-Based Inhibitors Act Directly on GlyT2.
Topics: Animals; Arachidonic Acids; Biophysical Phenomena; Endocannabinoids; Glycine; Glycine Plasma Membran | 2019 |
Role of hydrogen sulfide in the pain processing of non-diabetic and diabetic rats.
Topics: Algorithms; Alkynes; Animals; Blood Glucose; Cystathionine gamma-Lyase; Cysteine; Data Interpretatio | 2013 |
Inhibition of breast cancer-cell glutamate release with sulfasalazine limits cancer-induced bone pain.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Bone and Bones; Breast | 2014 |
Carrier-linked mutual prodrugs of biphenylacetic acid as a promising alternative to bioprecursor fenbufen: design, kinetics, and pharmacological studies.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Exper | 2014 |
Peripherally driven low-threshold inhibitory inputs to lamina I local-circuit and projection neurones: a new circuit for gating pain responses.
Topics: Animals; Electric Stimulation; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glycine; | 2014 |
Mechanisms of exercise-induced hypoalgesia.
Topics: Adolescent; Adult; Amides; Arachidonic Acids; Cross-Over Studies; Double-Blind Method; Endocannabino | 2014 |
Targeted ablation, silencing, and activation establish glycinergic dorsal horn neurons as key components of a spinal gate for pain and itch.
Topics: Animals; Disease Models, Animal; Glycine; Hyperalgesia; Mice; Mice, Transgenic; Nerve Net; Neurons; | 2015 |
Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn.
Topics: Animals; Behavior, Animal; Biomarkers; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases | 2015 |
Group III mGluR7 and mGluR8 in the amygdala differentially modulate nocifensive and affective pain behaviors.
Topics: Amygdala; Animals; Arthritis; Behavior, Animal; Benzhydryl Compounds; Benzoates; Disease Models, Ani | 2008 |
Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Burns; Cannabinoid Receptor Modulators; Disease Models, | 2008 |
Glycine receptor in rat hippocampal and spinal cord neurons as a molecular target for rapid actions of 17-beta-estradiol.
Topics: Animals; Cells, Cultured; Electrophysiology; Estradiol; Female; Glycine; Hippocampus; Male; Neurons; | 2009 |
Loss of spinal glycinergic neurons is not necessary for development of neuropathic pain in transgenic mice expressing enhanced green fluorescent protein in glycinergic neurons.
Topics: Analysis of Variance; Animals; Cell Count; Cell Death; Chromosomes, Artificial, Bacterial; Constrict | 2009 |
Antinociceptive effects of systemic lidocaine: involvement of the spinal glycinergic system.
Topics: Analgesics; Animals; Binding Sites; Glycine; Glycine Agents; Lidocaine; Organophosphonates; Pain; Qu | 2009 |
Increased glutamate and decreased glycine release in the rostral ventromedial medulla during induction of a pre-clinical model of chronic widespread muscle pain.
Topics: Acids; Analysis of Variance; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Disease M | 2009 |
Intracerebroventricular or intrathecal injection of glycine produces analgesia in thermal nociception and chemical nociception via glycine receptors.
Topics: Acetic Acid; Analgesia; Analgesics; Animals; Behavior, Animal; Female; Glycine; Hot Temperature; Inj | 2009 |
Isovaline causes inhibition by increasing potassium conductance in thalamic neurons.
Topics: Action Potentials; Analgesics; Animals; Animals, Newborn; Calcium Signaling; Dose-Response Relations | 2009 |
A determination of submicromolar concentrations of glycine in periaqueductal gray matter microdialyzates using capillary zone electrophoresis with contactless conductivity detection.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carrageenan; Electric Conductivity; Electrophoresi | 2009 |
Antinociception by motor cortex stimulation in the neuropathic rat: does the locus coeruleus play a role?
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Anesthetics, Local; Animals; | 2010 |
Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport.
Topics: Animals; Arachidonic Acids; Biological Transport; Glycine; Glycine Plasma Membrane Transport Protein | 2009 |
Analgesic properties of the novel amino acid, isovaline.
Topics: Acute Disease; Analgesics, Non-Narcotic; Animals; beta-Alanine; Chronic Disease; Cisterna Magna; Fem | 2010 |
Dependency of nociception facilitation or inhibition after periaqueductal gray matter stimulation on the context.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; | 2010 |
Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice.
Topics: Animals; Bicuculline; Disease Models, Animal; Glycine; Hot Temperature; Hyperalgesia; Injections; In | 2010 |
Differential distribution of activated spinal neurons containing glycine and/or GABA and expressing c-fos in acute and chronic pain models.
Topics: Animals; Capsaicin; Cell Count; Disease Models, Animal; Formaldehyde; gamma-Aminobutyric Acid; Gene | 2010 |
P2Y purinergic regulation of the glycine neurotransmitter transporters.
Topics: Adenosine Diphosphate; Animals; Brain Stem; Cells, Cultured; Cyclic GMP-Dependent Protein Kinases; E | 2011 |
Mitochondrial reactive oxygen species are activated by mGluR5 through IP3 and activate ERK and PKA to increase excitability of amygdala neurons and pain behavior.
Topics: Amygdala; Analysis of Variance; Animals; Antioxidants; Benzoates; Cyclic AMP-Dependent Protein Kinas | 2011 |
Metabotropic glutamate receptor subtype 8 in the amygdala modulates thermal threshold, neurotransmitter release, and rostral ventromedial medulla cell activity in inflammatory pain.
Topics: Amino Acids; Amygdala; Animals; Behavior, Animal; Benzoates; Blotting, Western; Carrageenan; Chromat | 2011 |
Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABA(A) receptors.
Topics: Action Potentials; Animals; Arthritis, Experimental; Benzoates; Bicuculline; Disease Models, Animal; | 2011 |
Spinal glycinergic and GABAergic neurons expressing C-fos after capsaicin stimulation are increased in rats with contralateral neuropathic pain.
Topics: Animals; Capsaicin; Freund's Adjuvant; Functional Laterality; GABAergic Neurons; Glycine; Inflammati | 2011 |
Decreases of glycine receptor expression induced by median nerve injury in the rat cuneate nucleus contribute to NPY release and c-Fos expression.
Topics: Animals; Gene Expression Regulation; Glycine; Immunohistochemistry; Median Nerve; Medulla Oblongata; | 2012 |
Activation of glycine site and GluN2B subunit of NMDA receptors is necessary for ERK/CREB signaling cascade in rostral anterior cingulate cortex in rats: implications for affective pain.
Topics: Animals; Cyclic AMP Response Element-Binding Protein; Extracellular Signal-Regulated MAP Kinases; Gl | 2012 |
Impaired glycinergic synaptic transmission and enhanced inflammatory pain in mice with reduced expression of vesicular GABA transporter (VGAT).
Topics: Animals; Behavior, Animal; Blotting, Western; Down-Regulation; Glycine; Inflammation; Mice; Mice, Kn | 2012 |
The functional role of ascending nociceptive control in defensive behavior.
Topics: Animals; Benzoates; Excitatory Amino Acid Antagonists; Glycine; Immobility Response, Tonic; Male; Mo | 2012 |
Role of metabotropic glutamate receptor 1 in the basolateral amygdala-driven prefrontal cortical deactivation in inflammatory pain in the rat.
Topics: Action Potentials; Amygdala; Animals; Bicuculline; Carrageenan; Chromones; Disease Models, Animal; E | 2013 |
Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Electromyography; Enzyme Inhibitors; Excitato | 2012 |
Activation of spinal group I metabotropic glutamate receptors in rats evokes local glutamate release and spontaneous nociceptive behaviors: effects of 2-methyl-6-(phenylethynyl)-pyridine pretreatment.
Topics: Animals; Behavior, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extrac | 2002 |
The analgesic domain of interferon-alpha2b contains an essential proline(39) residue.
Topics: Analgesics; Animals; Brain; Glycine; Humans; Interferon alpha-2; Interferon-alpha; Male; Molecular S | 2002 |
Bicuculline and strychnine suppress the mesencephalic locomotor region-induced inhibition of group III muscle afferent input to the dorsal horn.
Topics: Afferent Pathways; Animals; Bicuculline; Cats; Efferent Pathways; Female; GABA Antagonists; GABA-A R | 2003 |
Antinociceptive activity of the N-methyl-D-aspartate receptor antagonist N-(2-Indanyl)-glycinamide hydrochloride (CHF3381) in experimental models of inflammatory and neuropathic pain.
Topics: Animals; Carrageenan; Cold Temperature; Diabetes Mellitus; Disease Models, Animal; Drug Tolerance; E | 2003 |
Salt and wounds: a new mechanism for neuropathic pain.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glycine; Humans; K Cl- Cotransporters; Ner | 2003 |
Symptom patterns and pathophysiological mechanisms in dyspeptic patients with and without Helicobacter pylori.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Breath Tests; Caprylates; Carbon Radioisotopes; Dyspepsi | 2003 |
Retargeted clostridial endopeptidases: inhibition of nociceptive neurotransmitter release in vitro, and antinociceptive activity in in vivo models of pain.
Topics: Action Potentials; Animals; Botulinum Toxins, Type A; Cells, Cultured; Disease Models, Animal; Dose- | 2004 |
Neuroscience. Locating a new step in pain's pathway.
Topics: Animals; Dinoprostone; Glycine; Inflammation; Mice; Mice, Knockout; Neurons; Pain; Receptors, Glycin | 2004 |
GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization.
Topics: Amino Acid Sequence; Animals; Cell Line; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Female; | 2004 |
Nicotine differentially activates inhibitory and excitatory neurons in the dorsal spinal cord.
Topics: Action Potentials; Afferent Pathways; Analgesics; Animals; Biomarkers; Calbindins; Dendrites; Excita | 2004 |
Electrophysiological characterization of N-methyl-D-aspartate receptors in rat dorsal root ganglia neurons.
Topics: Animals; Calcium; Calcium Signaling; Cells, Cultured; Colon; Dose-Response Relationship, Drug; Excit | 2004 |
Adenosine inhibits GABAergic and glycinergic transmission in adult rat substantia gelatinosa neurons.
Topics: 4-Aminopyridine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; Colforsin; GABA Antagon | 2004 |
The spinal antinociceptive effect of nocistatin in neuropathic rats is blocked by D-serine.
Topics: Analgesics, Opioid; Anesthesia, Spinal; Animals; Dose-Response Relationship, Drug; Glycine; Hyperalg | 2004 |
An antisense oligonucleotide to the N-methyl-D-aspartate (NMDA) subunit NMDAR1 attenuates NMDA-induced nociception, hyperalgesia, and morphine tolerance.
Topics: Analgesics, Opioid; Animals; Autoradiography; Behavior, Animal; Dose-Response Relationship, Drug; Dr | 2005 |
Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype.
Topics: Animals; Behavior, Animal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; | 2005 |
Effect of morphine on deep dorsal horn projection neurons depends on spinal GABAergic and glycinergic tone: implications for reduced opioid effect in neuropathic pain.
Topics: Administration, Topical; Analgesics, Opioid; Animals; Behavior, Animal; Electrophysiology; gamma-Ami | 2005 |
Morphological evidence for GABA/glycine-cocontaining terminals in synaptic contact with neurokinin-1 receptor-expressing neurons in the sacral dorsal commissural nucleus of the rat.
Topics: Animals; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glycine; | 2005 |
CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats.
Topics: Administration, Oral; Amines; Analgesics; Animals; Behavior, Animal; Capsaicin; Cyclohexanecarboxyli | 2005 |
Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect?
Topics: Animals; Anxiety; D-Amino-Acid Oxidase; Excitatory Amino Acid Antagonists; Fear; Glycine; Gyrus Cing | 2006 |
Substantia Gelatinosa neurons in defined-medium organotypic slice culture are similar to those in acute slices from young adult rats.
Topics: Action Potentials; Afferent Pathways; Aging; Animals; Chronic Disease; Culture Media; Electric Stimu | 2006 |
Design and characterization of a noncompetitive antagonist of the transient receptor potential vanilloid subunit 1 channel with in vivo analgesic and anti-inflammatory activity.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arginine; Capsaicin; Chlorocebus aethiops; COS Cells; | 2006 |
Intracellular messengers involved in spontaneous pain, heat hyperalgesia, and mechanical allodynia induced by intrathecal dihydroxyphenylglycine.
Topics: Animals; Extracellular Signal-Regulated MAP Kinases; Glycine; Hot Temperature; Hyperalgesia; Hyperes | 2006 |
Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice.
Topics: Analysis of Variance; Animals; Benzhydryl Compounds; Benzoates; Carrageenan; Dinucleoside Phosphates | 2007 |
Subarachnoid transplant of a human neuronal cell line attenuates chronic allodynia and hyperalgesia after excitotoxic spinal cord injury in the rat.
Topics: Animals; Antimetabolites; Bromodeoxyuridine; Cell Differentiation; Cell Line; Cell Transplantation; | 2007 |
Chiral tetrahydroquinoline derivatives as potent anti-hyperalgesic agents in animal models of sustained inflammation and chronic neuropathic pain.
Topics: Animals; Biological Availability; Disease Models, Animal; Glycine; Hydroquinones; Hyperalgesia; Infl | 2007 |
Decrease in N-methyl-D-aspartic acid receptor-NR2B subunit levels by intrathecal short-hairpin RNA blocks group I metabotropic glutamate receptor-mediated hyperalgesia.
Topics: Animals; Excitatory Amino Acid Antagonists; Gene Silencing; Glycine; Hyperalgesia; Male; Mice; Pain; | 2007 |
BDNF-mediated modulation of GABA and glycine release in dorsal horn lamina II from postnatal rats.
Topics: Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Dendrites; gamma-Aminobutyric Acid; Gl | 2007 |
Role of spinal metabotropic glutamate receptor subtype 5 in the development of tolerance to morphine-induced antinociception in rat.
Topics: Analgesics, Opioid; Animals; Calcium; Drug Administration Schedule; Drug Tolerance; Excitatory Amino | 2007 |
Enhanced 3,5-dihydroxyphenylglycine-induced sustained nociceptive behaviors in rats with neuropathy or chronic inflammation.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Excitatory Amino Acid Agoni | 2007 |
A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore.
Topics: Data Interpretation, Statistical; DNA, Complementary; Electrophysiology; Glycine; Humans; Hydrogen B | 2007 |
Actions of N-arachidonyl-glycine in a rat inflammatory pain model.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Disease Models, Animal; Glycine; Inflamma | 2007 |
Glycine inhibitory dysfunction turns touch into pain through PKCgamma interneurons.
Topics: Animals; Glycine; Interneurons; Male; Pain; Protein Kinase C; Rats; Rats, Sprague-Dawley | 2007 |
mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo.
Topics: Analgesics, Opioid; Animals; Calcium Signaling; Central Nervous System; Dose-Response Relationship, | 2008 |
Increased C-fiber nociceptive input potentiates inhibitory glycinergic transmission in the spinal dorsal horn.
Topics: Animals; Capsaicin; Glycine; Inhibitory Postsynaptic Potentials; Male; Nerve Fibers, Unmyelinated; N | 2008 |
A nociceptive-intensity-dependent role for hydrogen sulphide in the formalin model of persistent inflammatory pain.
Topics: Alkynes; Animals; Enzyme Inhibitors; Formaldehyde; Glycine; Hydrogen Sulfide; Inflammation; Irritant | 2008 |
Glycine transporter inhibitors as a potential therapeutic strategy for chronic pain with memory impairment.
Topics: Acute Disease; Analgesics; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Glycine; | 2008 |
Expression of adenosine A 2A receptors in the rat lumbar spinal cord and implications in the modulation of N-methyl-d-aspartate receptor currents.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Blotting, Western; Glycine; Lumbosacral Region; | 2008 |
Ronald Tasker Award: Intrathecal transplantation of a human neuronal cell line for the treatment of neuropathic pain in a spinal cord injury model.
Topics: Animals; Carcinoma, Embryonal; Cell Line, Tumor; gamma-Aminobutyric Acid; Glycine; Injections, Spina | 2007 |
Transmitters involved in central processing of nociceptive information.
Topics: Animals; Enkephalins; gamma-Aminobutyric Acid; Glycine; Humans; Neural Inhibition; Neurons, Afferent | 1982 |
Antinociceptive effect of systemic PC 12, a prodrug mixed inhibitor of enkephalin-degrading enzymes, in normal and arthritic rats.
Topics: Aminopeptidases; Analgesics; Animals; Arthritis, Experimental; CD13 Antigens; Dose-Response Relation | 1993 |
Glycine and GABAA antagonists reduce the inhibition of primate spinothalamic tract neurons produced by stimulation in periaqueductal gray.
Topics: Animals; Bicuculline; Brain Mapping; Dose-Response Relationship, Drug; Electric Stimulation; GABA-A | 1994 |
Effects of intrathecal strychnine and bicuculline on nerve compression-induced thermal hyperalgesia and selective antagonism by MK-801.
Topics: Animals; Bicuculline; Dizocilpine Maleate; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid | 1993 |
(+)-HA 966, a partial agonist at the glycine site coupled to NMDA receptors, blocks formalin-induced pain in mice.
Topics: Animals; Formaldehyde; Glycine; Hindlimb; Male; Mice; Pain; Pyrrolidinones; Receptors, N-Methyl-D-As | 1993 |
Prostaglandin D2 inhibits prostaglandin E2-induced allodynia in conscious mice.
Topics: Adrenergic Agonists; Animals; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; gamma-Amino | 1996 |
Strychnine-dependent allodynia in the urethane-anesthetized rat is segmentally distributed and prevented by intrathecal glycine and betaine.
Topics: Anesthetics, Intravenous; Animals; Betaine; Evoked Potentials, Somatosensory; Glycine; Glycine Agent | 1995 |
The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception.
Topics: Aminobutyrates; Analysis of Variance; Animals; Benzoates; Cycloleucine; Cyclopropanes; Excitatory Am | 1996 |
Inhibition of nociceptin-induced allodynia in conscious mice by prostaglandin D2.
Topics: Animals; Bucladesine; Dibutyryl Cyclic GMP; Glycine; Hyperalgesia; Male; Mice; Narcotic Antagonists; | 1997 |
Behavioural and electrophysiological evidence supporting a role for group I metabotropic glutamate receptors in the mediation of nociceptive inputs to the rat spinal cord.
Topics: Alanine; Animals; Antihypertensive Agents; Behavior, Animal; Benzothiadiazines; Cycloleucine; Electr | 1997 |
[Preemptive analgesia].
Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; Formaldehyde; GABA Antagonists; gamma-Aminob | 1997 |
In vivo antinociceptive activity of anti-rat mGluR1 and mGluR5 antibodies in rats.
Topics: Analgesics; Animals; Excitatory Amino Acid Antagonists; Glycine; Immunoglobulin G; Injections, Spina | 1998 |
Involvement of the central tachykinin NK1 receptor during maintenance of mechanical hypersensitivity induced by diabetes in the rat.
Topics: Animals; Benzofurans; Carbamates; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Electrophy | 1998 |
Inflammation alters the effects of mGlu receptor agonists on spinal nociceptive neurones.
Topics: Animals; Carrageenan; Cycloleucine; Excitatory Amino Acid Antagonists; Glycine; Inflammation; Male; | 1998 |
Effects of NMDA receptor antagonists on nociceptive responses in vivo: comparison of antagonists acting at the glycine site with uncompetitive antagonists.
Topics: Animals; Decerebrate State; Excitatory Amino Acid Antagonists; Glycine; Male; Pain; Phthalazines; Ra | 1998 |
The antinociceptive effect of combined systemic administration of morphine and the glycine/NMDA receptor antagonist, (+)-HA966 in a rat model of peripheral neuropathy.
Topics: Analgesics, Opioid; Animals; Binding Sites; Cold Temperature; Disease Models, Animal; Dose-Response | 1998 |
Effects of ACEA-1328, a NMDA receptor/glycine site antagonist, on U50,488H-induced antinociception and tolerance.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 1999 |
Evaluation of the activity of a novel metabotropic glutamate receptor antagonist (+/-)-2-amino-2-(3-cis and trans-carboxycyclobutyl-3-(9-thioxanthyl)propionic acid) in the in vitro neonatal spinal cord and in an in vivo pain model.
Topics: Acetic Acid; Animals; Animals, Newborn; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antag | 2000 |
Long-term intrathecal administration of glycine prevents mechanical hyperalgesia in a rat model of neuropathic pain.
Topics: Animals; Glycine; Hyperalgesia; Injections, Spinal; Ligation; Male; Mechanoreceptors; Nervous System | 2000 |
Induction of homosynaptic long-term depression at spinal synapses of sensory a delta-fibers requires activation of metabotropic glutamate receptors.
Topics: Animals; Benzoates; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic | 2000 |
Electrophysiologic evidence for increased endogenous gabaergic but not glycinergic inhibitory tone in the rat spinal nerve ligation model of neuropathy.
Topics: Animals; Bicuculline; Cold Temperature; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; G | 2001 |
Peripheral group I metabotropic glutamate receptors modulate nociception in mice.
Topics: Animals; Chromones; Excitatory Amino Acid Antagonists; Glycine; Hindlimb; Hot Temperature; Immunohis | 2001 |
Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain.
Topics: Alanine; Amidohydrolases; Amino Acids; Animals; Arachidonic Acid; Arachidonic Acids; Brain; Calcium; | 2001 |
Metabotropic glutamate 1alpha receptors on peripheral primary afferent fibers: their role in nociception.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excita | 2001 |
GV196771A, an NMDA receptor/glycine site antagonist, attenuates mechanical allodynia in neuropathic rats and reduces tolerance induced by morphine in mice.
Topics: Animals; Behavior, Animal; Binding Sites; Constriction, Pathologic; Disease Models, Animal; Dose-Res | 2001 |
Synaptic connections between trigemino-parabrachial projection neurons and gamma-aminobutyric acid- and glycine-immunoreactive terminals in the rat.
Topics: Animals; Dendrites; gamma-Aminobutyric Acid; Glycine; Horseradish Peroxidase; Immunohistochemistry; | 2001 |
PGE(2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cholera Toxin; Cyclic AMP-Depende | 2002 |
Group I metabotropic glutamate receptors in spinal cord injury: roles in neuroprotection and the development of chronic central pain.
Topics: Animals; Benzoates; Chronic Disease; Excitatory Amino Acid Antagonists; Glycine; Hyperalgesia; Locom | 2002 |
Attenuation of thermal nociception and hyperalgesia by VR1 blockers.
Topics: Animals; Calcium; Capsaicin; Dose-Response Relationship, Drug; Electrophysiology; Glycine; Hot Tempe | 2002 |
Investigation of a pain syndrome of spinal origin (on the concept of the generator mechanism of the pain syndrome).
Topics: Animals; Denervation; Glycine; Hindlimb; Neural Inhibition; Neurons, Afferent; Pain; Rats; Spinal Co | 1975 |
Light and electron microscope study of GABA-immunoreactive neurones in lamina III of rat spinal cord.
Topics: Animals; gamma-Aminobutyric Acid; Glycine; Male; Microscopy, Electron; Neurons; Neurons, Afferent; P | 1992 |
Modulation of neuropathic pain behavior in rats by spinal disinhibition and NMDA receptor blockade of injury discharge.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Dizocilpine Maleate; Electric Stimulation; G | 1991 |
Influence of glycine on morphine-induced antinociception in mice.
Topics: Acetylcholine; Analgesics; Animals; Behavior, Animal; Drug Synergism; Female; Glycine; Hot Temperatu | 1990 |
Blockage of substance P-induced scratching behavior in rats by the intrathecal administration of inhibitory amino acid agonists.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Glycine; Injections, Spinal; Mu | 1989 |
Novel inhibitors of enkephalin-degrading enzymes. II: N5'-substituted-4-thioxohydantoic acids as aminopeptidase inhibitors.
Topics: Aminopeptidases; Analgesics; Animals; Glycine; Indicators and Reagents; Leucine; Mice; Naloxone; Nep | 1989 |
Prevention of the convulsant and hyperalgesic action of strychnine by intrathecal glycine and related amino acids.
Topics: Alanine; Amino Acids; Animals; Betaine; Glycine; Injections, Spinal; Pain; Rats; Rats, Inbred Strain | 1988 |
Hyperalgesia induced by altered glycinergic activity at the spinal cord.
Topics: Animals; Behavior, Animal; Castration; Female; Glycine; Hyperalgesia; Hyperesthesia; Injections, Spi | 1985 |
[The value of avafortan in a general surgery service].
Topics: Adult; Aged; Alkanesulfonates; Analgesics; Antipyrine; Ethylamines; Female; Glycine; Humans; Male; M | 1971 |
[Experimental trigeminal neuralgia (with reference to the concept of the generator mechanism of the pain syndrome)].
Topics: Animals; Disease Models, Animal; Electromyography; Facial Muscles; Glycine; Neural Inhibition; Pain; | 1974 |
[Study of the pain syndrome of spinal origin (the concept of a generative mechanism for the pain syndrome)].
Topics: Animals; Denervation; Femoral Nerve; Glycine; Injections, Spinal; Lumbosacral Plexus; Neural Inhibit | 1974 |
[Experiences with Ambene in gynecological practice].
Topics: Adolescent; Adult; Aluminum; Dexamethasone; Drug Combinations; Female; Genital Diseases, Female; Gly | 1972 |
[Value of Avafortan sugar-coated pills in the treatment of pain in gynecology].
Topics: Antipyrine; Female; Genital Diseases, Female; Glycine; Humans; Methylamines; Pain; Parasympatholytic | 1971 |