Page last updated: 2024-10-18

glycine and Pain

glycine has been researched along with Pain in 140 studies

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"Since glycinergic neurotransmission plays an important inhibitory role in the processing of sensory and motor information, intrathecal glycine (ITG) administration may be a potential therapy for both pain and movement disorders in patients with complex regional pain syndrome (CRPS)."9.14Intrathecal glycine for pain and dystonia in complex regional pain syndrome. ( Marinus, J; Munts, AG; Onkenhout, W; Teepe-Twiss, IM; van der Plas, AA; van Gerven, JM; van Hilten, JJ; Voormolen, JH, 2009)
"Although the glycine antagonists show anti-hyperalgesic action in animal models of neuropathic pain, GV196771 does not appear to be an effective treatment in subjects with chronic neuropathic pain."9.10A randomized, double-blind, placebo-controlled trial of a glycine antagonist in neuropathic pain. ( Backonja, MM; Dotson, RM; Dworkin, RH; Galer, BS; Katz, NP; Meisner, PD; Quessy, SN; Rauck, RL; Rowbotham, MC; Wallace, MS, 2002)
"Indantadol is an oral and nonselective monoamine oxidase inhibitor and NMDA antagonist that is being developed by Vernalis plc, under license from Chiesi Farmaceutici SpA, for the potential treatment of neuropathic pain."8.84Indantadol, a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain. ( Coluzzi, F; Mattia, C, 2007)
"Glycine receptors (GlyRs) play key roles in the processing of inflammatory pain."8.31AAV-glycine receptor α3 alleviates CFA-induced inflammatory pain by downregulating ERK phosphorylation and proinflammatory cytokine expression in SD rats. ( Chang, LL; Cheng, KI; Kwan, AL; Tseng, KY; Wang, HC, 2023)
" Immunodeficient mice were inoculated intrafemorally with the human breast adenocarcinoma cell line MDA-MB-231, then treated 14days later via mini-osmotic pumps inserted intraperitoneally with sulfasalazine, (S)-4-carboxyphenylglycine, or vehicle."7.80Inhibition of breast cancer-cell glutamate release with sulfasalazine limits cancer-induced bone pain. ( Seidlitz, EP; Singh, G; Ungard, RG, 2014)
"Either the glycine site or the GluN2B subunit of NMDARs participates in the phosphorylation of ERK and CREB induced by bath application of NMDA in brain slices or hindpaw injection of 5% formalin in rats, and these might be fundamental molecular mechanisms underlying pain affect."7.78Activation of glycine site and GluN2B subunit of NMDA receptors is necessary for ERK/CREB signaling cascade in rostral anterior cingulate cortex in rats: implications for affective pain. ( Cao, H; Ren, WH; Zhang, YQ; Zhao, ZQ; Zhu, MY, 2012)
"The inhibitory transmitters GABA and glycine play an important role in modulating pain transmission, both in normal and in pathological situations."7.76Differential distribution of activated spinal neurons containing glycine and/or GABA and expressing c-fos in acute and chronic pain models. ( Duraku, LS; Holstege, JC; Hossaini, M; Jongen, JLM; Saraç, Ç, 2010)
" Glycine or muscimol reduced bicuculline-induced allodynia regardless of the administration site, whereas intrathecal taurine reduced bicuculline-induced allodynia."7.76Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice. ( Lee, IO; Lim, ES, 2010)
" The aim of the present study was to evaluate whether a specific loss of glycinergic neurons is necessary to develop hyperalgesia and allodynia in the chronic constriction injury (CCI) model of neuropathic pain."7.75Loss of spinal glycinergic neurons is not necessary for development of neuropathic pain in transgenic mice expressing enhanced green fluorescent protein in glycinergic neurons. ( Bauer, I; Braun, S; Hermanns, H; Lipfert, P; Muth-Selbach, U; Werdehausen, R, 2009)
"In the present study we examined the effect of NA-glycine in a rat model of inflammatory pain."7.74Actions of N-arachidonyl-glycine in a rat inflammatory pain model. ( Mitchell, VA; Succar, R; Vaughan, CW, 2007)
"An increase in endogenous glycine via glycine transporter 1 blockade not only results in a net inhibitory influence on pain transmission at the spinal level but also supraspinally relieves decreased synaptic efficacy presumably related to cognitive disturbance often described in patients with chronic pain."7.74Glycine transporter inhibitors as a potential therapeutic strategy for chronic pain with memory impairment. ( Kodama, D; Ono, H; Takasu, K; Tanabe, M; Yamaguchi, S, 2008)
"Here, we have examined the effect of the novel antinociceptive agent CHF3381 on the development of nocifensive behaviour as well as secondary mechanical allodynia and hyperalgesia induced by intraplantar injection of capsaicin in rats."7.73CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats. ( Bassani, F; Bergamaschi, M; Tonino Bolzoni, P; Villetti, G, 2005)
" In this study, we tested the hypothesis that removal of GABAergic and glycinergic inhibitory inputs attenuates the effect of morphine on dorsal horn projection neurons and the reduced spinal GABAergic tone contributes to attenuated morphine effect in neuropathic pain."7.73Effect of morphine on deep dorsal horn projection neurons depends on spinal GABAergic and glycinergic tone: implications for reduced opioid effect in neuropathic pain. ( Chen, SR; Chen, YP; Pan, HL, 2005)
"Neuropathic pain has been postulated to be mediated, in part, by amino acid neurotransmitters including glycine."7.70Long-term intrathecal administration of glycine prevents mechanical hyperalgesia in a rat model of neuropathic pain. ( Huang, W; Simpson, RK, 2000)
" We recently showed that intrathecal administration of nociceptin induced allodynia by innocuous tactile stimuli and hyperalgesia by noxious thermal stimuli in conscious mice."7.69Inhibition of nociceptin-induced allodynia in conscious mice by prostaglandin D2. ( Ito, S; Minami, T; Mori, H; Nishizawa, M; Okuda-Ashitaka, E, 1997)
"Tranexamic acid (TXA) is an antifibrinolytic agent widely used to reduce blood loss during surgery."5.42Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn. ( Baba, H; Kamiya, Y; Kohno, T; Ohashi, M; Ohashi, N; Sasaki, M, 2015)
"Hydrogen sulfide (H2S) is a gasotransmitter endogenously generated from the metabolism of L-cysteine by action of two main enzymes called cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE)."5.39Role of hydrogen sulfide in the pain processing of non-diabetic and diabetic rats. ( Araiza-Saldaña, CI; Barragán-Iglesias, P; Flores-Murrieta, FJ; Godínez-Chaparro, B; Navarrete, A; Roa-Coria, JE; Rocha-González, HI; Torres-López, JE; Velasco-Xolalpa, ME, 2013)
"Since glycinergic neurotransmission plays an important inhibitory role in the processing of sensory and motor information, intrathecal glycine (ITG) administration may be a potential therapy for both pain and movement disorders in patients with complex regional pain syndrome (CRPS)."5.14Intrathecal glycine for pain and dystonia in complex regional pain syndrome. ( Marinus, J; Munts, AG; Onkenhout, W; Teepe-Twiss, IM; van der Plas, AA; van Gerven, JM; van Hilten, JJ; Voormolen, JH, 2009)
" The analgesic activity of CHF3381 was investigated in the heat-capsaicin human pain model and compared with those of gabapentin."5.12CHF3381, a N-methyl-D-aspartate receptor antagonist and monoamine oxidase-A inhibitor, attenuates secondary hyperalgesia in a human pain model. ( Dahl, JB; Fabbri, L; Hilsted, KL; Imbimbo, BP; Mathiesen, O, 2006)
"Although the glycine antagonists show anti-hyperalgesic action in animal models of neuropathic pain, GV196771 does not appear to be an effective treatment in subjects with chronic neuropathic pain."5.10A randomized, double-blind, placebo-controlled trial of a glycine antagonist in neuropathic pain. ( Backonja, MM; Dotson, RM; Dworkin, RH; Galer, BS; Katz, NP; Meisner, PD; Quessy, SN; Rauck, RL; Rowbotham, MC; Wallace, MS, 2002)
" We therefore investigated the effects of a commercially available artificial sweetener (10 parts cyclamate and 1 part saccharin), glycine (sweet amino acid) or breast milk in reducing reaction to pain as compared with a placebo."5.09Artificial sweetener reduces nociceptive reaction in term newborn infants. ( Baumgartner, R; Bucher, HU; Bucher, N; Fauchère, JC; Seiler, M, 2000)
"Indantadol is an oral and nonselective monoamine oxidase inhibitor and NMDA antagonist that is being developed by Vernalis plc, under license from Chiesi Farmaceutici SpA, for the potential treatment of neuropathic pain."4.84Indantadol, a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain. ( Coluzzi, F; Mattia, C, 2007)
"Glycine receptors (GlyRs) play key roles in the processing of inflammatory pain."4.31AAV-glycine receptor α3 alleviates CFA-induced inflammatory pain by downregulating ERK phosphorylation and proinflammatory cytokine expression in SD rats. ( Chang, LL; Cheng, KI; Kwan, AL; Tseng, KY; Wang, HC, 2023)
"The endogenous lipids N-arachidonylglycine and oleoyl-l-carnitine are potential therapeutic leads in the treatment of chronic pain through their inhibition of the glycine transporter GlyT2."3.91Lipid-Based Inhibitors Act Directly on GlyT2. ( O'Mara, ML; Schumann-Gillett, A, 2019)
" Immunodeficient mice were inoculated intrafemorally with the human breast adenocarcinoma cell line MDA-MB-231, then treated 14days later via mini-osmotic pumps inserted intraperitoneally with sulfasalazine, (S)-4-carboxyphenylglycine, or vehicle."3.80Inhibition of breast cancer-cell glutamate release with sulfasalazine limits cancer-induced bone pain. ( Seidlitz, EP; Singh, G; Ungard, RG, 2014)
"Either the glycine site or the GluN2B subunit of NMDARs participates in the phosphorylation of ERK and CREB induced by bath application of NMDA in brain slices or hindpaw injection of 5% formalin in rats, and these might be fundamental molecular mechanisms underlying pain affect."3.78Activation of glycine site and GluN2B subunit of NMDA receptors is necessary for ERK/CREB signaling cascade in rostral anterior cingulate cortex in rats: implications for affective pain. ( Cao, H; Ren, WH; Zhang, YQ; Zhao, ZQ; Zhu, MY, 2012)
" Glycine or muscimol reduced bicuculline-induced allodynia regardless of the administration site, whereas intrathecal taurine reduced bicuculline-induced allodynia."3.76Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice. ( Lee, IO; Lim, ES, 2010)
"Isovaline reduced responses in mouse pain models without producing acute toxicity, possibly by enhancing receptor modulation of nociceptive information."3.76Analgesic properties of the novel amino acid, isovaline. ( Chung, CC; MacLeod, BA; Puil, E; Ries, CR; Schwarz, SK; Wang, JT, 2010)
"The inhibitory transmitters GABA and glycine play an important role in modulating pain transmission, both in normal and in pathological situations."3.76Differential distribution of activated spinal neurons containing glycine and/or GABA and expressing c-fos in acute and chronic pain models. ( Duraku, LS; Holstege, JC; Hossaini, M; Jongen, JLM; Saraç, Ç, 2010)
" The effects on the pain threshold index in hot-plate test and the writhing times in acetic acid-induced writhing test were observed."3.75Intracerebroventricular or intrathecal injection of glycine produces analgesia in thermal nociception and chemical nociception via glycine receptors. ( Chen, HS; Cheng, MY; Cheng, W; Feng, T; Liu, GJ; Wang, S; Yin, Q; Zeng, YM, 2009)
" Whether glycinergic mechanisms, which play a pivotal role in pain modulation, are involved in lidocaine-induced antinociception is hitherto unclear."3.75Antinociceptive effects of systemic lidocaine: involvement of the spinal glycinergic system. ( Bauer, I; Freynhagen, R; Hermanns, H; Kollosche, K; Lipfert, P; Muth-Selbach, U; Stegmann, JU, 2009)
" The aim of the present study was to evaluate whether a specific loss of glycinergic neurons is necessary to develop hyperalgesia and allodynia in the chronic constriction injury (CCI) model of neuropathic pain."3.75Loss of spinal glycinergic neurons is not necessary for development of neuropathic pain in transgenic mice expressing enhanced green fluorescent protein in glycinergic neurons. ( Bauer, I; Braun, S; Hermanns, H; Lipfert, P; Muth-Selbach, U; Werdehausen, R, 2009)
" N-Arachidonylglycine (NAGly) is an endogenous inhibitor of GLYT2 with little or no effect on GLYT1 and is analgesic in rat models of neuropathic and inflammatory pain."3.75Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport. ( Edington, AR; Kassiou, M; McKinzie, AA; Reynolds, AJ; Ryan, RM; Vandenberg, RJ, 2009)
"The rare amino acid isovaline has analgesic properties in pain models and is a structural analogue of the inhibitory neurotransmitter glycine."3.75Isovaline causes inhibition by increasing potassium conductance in thalamic neurons. ( Cooke, JE; Mathers, DA; Puil, E, 2009)
"In this study, the effect of (S)-3,4-dicarboxyphenylglycine (DCPG), a selective mGlu8 receptor agonist, has been investigated in inflammatory and neuropathic pain models in order to elucidate the role of mGlu8 receptor in modulating pain perception."3.74Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. ( de Novellis, V; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Scafuro, MA; Vita, D, 2007)
"In the present study we examined the effect of NA-glycine in a rat model of inflammatory pain."3.74Actions of N-arachidonyl-glycine in a rat inflammatory pain model. ( Mitchell, VA; Succar, R; Vaughan, CW, 2007)
" This efficient route enabled to scale up the synthesis of an orally bioavailable glycine antagonist showing outstanding in vivo anti-hyperalgesic activity in different animal models of sustained inflammation and chronic neuropathic pain."3.74Chiral tetrahydroquinoline derivatives as potent anti-hyperalgesic agents in animal models of sustained inflammation and chronic neuropathic pain. ( Alvaro, G; Barnaby, RJ; Bertani, B; Corsi, M; Di Fabio, R; Donati, D; Gentile, G; Giacobbe, S; Pentassuglia, G; Pizzi, DM; Quartaroli, M; Ratti, E; Spada, S; Vitulli, G, 2007)
"The present study investigated the hypothesis that hydrogen sulfide (H2S) is pro-nociceptive in the formalin model of persistent inflammatory pain in the adult rat."3.74A nociceptive-intensity-dependent role for hydrogen sulphide in the formalin model of persistent inflammatory pain. ( Cheng, Y; Khanna, S; Lee, AT; Li, L; Moore, PK; Shah, JJ, 2008)
"An increase in endogenous glycine via glycine transporter 1 blockade not only results in a net inhibitory influence on pain transmission at the spinal level but also supraspinally relieves decreased synaptic efficacy presumably related to cognitive disturbance often described in patients with chronic pain."3.74Glycine transporter inhibitors as a potential therapeutic strategy for chronic pain with memory impairment. ( Kodama, D; Ono, H; Takasu, K; Tanabe, M; Yamaguchi, S, 2008)
"Here, we have examined the effect of the novel antinociceptive agent CHF3381 on the development of nocifensive behaviour as well as secondary mechanical allodynia and hyperalgesia induced by intraplantar injection of capsaicin in rats."3.73CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats. ( Bassani, F; Bergamaschi, M; Tonino Bolzoni, P; Villetti, G, 2005)
" In this study, we tested the hypothesis that removal of GABAergic and glycinergic inhibitory inputs attenuates the effect of morphine on dorsal horn projection neurons and the reduced spinal GABAergic tone contributes to attenuated morphine effect in neuropathic pain."3.73Effect of morphine on deep dorsal horn projection neurons depends on spinal GABAergic and glycinergic tone: implications for reduced opioid effect in neuropathic pain. ( Chen, SR; Chen, YP; Pan, HL, 2005)
" We show that the conjugate of arachidonic acid and glycine (N-arachidonylglycine (NAGly)) is present in bovine and rat brain as well as other tissues and that it suppresses tonic inflammatory pain."3.71Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. ( Bisogno, T; Burstein, S; Chang, SY; Coop, A; De Petrocellis, L; Di Marzo, V; Huang, SM; Maeda, DY; Petros, TJ; Sivakumar, R; Walker, JM; Zavitsanos, PA; Zipkin, RE, 2001)
"Changes in the inhibitory activity mediated by gamma-aminobutyric acid (GABA) and glycine, acting at spinal GABAA receptors and strychnine-sensitive glycine receptors, are of interest in the development of neuropathic pain."3.71Electrophysiologic evidence for increased endogenous gabaergic but not glycinergic inhibitory tone in the rat spinal nerve ligation model of neuropathy. ( Basu, A; Dickenson, AH; Kontinen, VK; Stanfa, LC, 2001)
" This study examined the effects of the metabotropic glutamate receptor agonists (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3R)-ACPD), (S)-3,5-dihydroxyphenylglycine ((S)-3,5-DHPG) and (1S,3S)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3S)-ACPD) on the electrically evoked responses of dorsal horn neurones recorded in normal animals and in animals 3 h after the induction of carrageenan inflammation."3.70Inflammation alters the effects of mGlu receptor agonists on spinal nociceptive neurones. ( Dickenson, AH; Stanfa, LC, 1998)
"Neuropathic pain has been postulated to be mediated, in part, by amino acid neurotransmitters including glycine."3.70Long-term intrathecal administration of glycine prevents mechanical hyperalgesia in a rat model of neuropathic pain. ( Huang, W; Simpson, RK, 2000)
" We evaluated the ability of the functional antagonist at the glycine site of the N-methyl-D-aspartate (NMDA) receptor complex, (+)-(1-Hydroxy-3-aminopyrrolodine-2-one) ((+)-HA966), to modulate the antinociceptive action of systemic morphine in a rat model of neuropathic pain produced by chronic constriction injury to the sciatic nerve."3.70The antinociceptive effect of combined systemic administration of morphine and the glycine/NMDA receptor antagonist, (+)-HA966 in a rat model of peripheral neuropathy. ( Christensen, D; Guilbaud, G; Idänpään-Heikkilä, JJ; Kayser, V, 1998)
" We recently showed that intrathecal administration of nociceptin induced allodynia by innocuous tactile stimuli and hyperalgesia by noxious thermal stimuli in conscious mice."3.69Inhibition of nociceptin-induced allodynia in conscious mice by prostaglandin D2. ( Ito, S; Minami, T; Mori, H; Nishizawa, M; Okuda-Ashitaka, E, 1997)
"A twice daily regimen of CHF3381 appears to be adequate from a pharmacokinetic and pharmacodynamic perspective."2.71Steady-state pharmacokinetics and pharmacodynamics of CHF3381, a novel antineuropathic pain agent, in healthy subjects. ( Astruc, B; Dostert, P; Fabbri, L; Imbimbo, BP; Mariotti, F; Tarral, A, 2005)
"The PTX-induced thermal hyperalgesia peaked between day 2 and 4, but no cold allodynia is observed; i."2.42Implications of intrathecal pertussis toxin animal model on the cellular mechanisms of neuropathic pain syndrome. ( Chang, YC; Wen, ZH; Wong, CS, 2003)
"Tranexamic acid (TXA) is an antifibrinolytic agent widely used to reduce blood loss during surgery."1.42Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn. ( Baba, H; Kamiya, Y; Kohno, T; Ohashi, M; Ohashi, N; Sasaki, M, 2015)
"Hydrogen sulfide (H2S) is a gasotransmitter endogenously generated from the metabolism of L-cysteine by action of two main enzymes called cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE)."1.39Role of hydrogen sulfide in the pain processing of non-diabetic and diabetic rats. ( Araiza-Saldaña, CI; Barragán-Iglesias, P; Flores-Murrieta, FJ; Godínez-Chaparro, B; Navarrete, A; Roa-Coria, JE; Rocha-González, HI; Torres-López, JE; Velasco-Xolalpa, ME, 2013)
"Using pharmacological approaches and siRNA-mediated protein knockdown methodology, we elucidate the molecular mechanisms of GLYT regulation."1.37P2Y purinergic regulation of the glycine neurotransmitter transporters. ( Aragón, C; Delicado, EG; Jiménez, E; López-Corcuera, B; Miras-Portugal, MT; Pérez-Sen, R; Zafra, F, 2011)
"Hyperalgesia was assessed in mice using the tail immersion test."1.35mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo. ( Carroll, FI; Dewey, WL; Gabra, BH; Navarro, HA; Smith, FL, 2008)
"Glycine is an important inhibitory neurotransmitter in the spinal cord, but it also acts as a coagonist at the glycine site of N-methyl-d-aspartate (NMDA) receptors to potentiate nociceptive transmission."1.35Increased C-fiber nociceptive input potentiates inhibitory glycinergic transmission in the spinal dorsal horn. ( Chen, SR; Pan, HL; Zhang, HM; Zhou, HY, 2008)
" Unlike morphine, CHF3381 chronic administration was not accompanied by the development of tolerance in the formalin test."1.32Antinociceptive activity of the N-methyl-D-aspartate receptor antagonist N-(2-Indanyl)-glycinamide hydrochloride (CHF3381) in experimental models of inflammatory and neuropathic pain. ( Barbieri, M; Bassani, F; Bergamaschi, M; Bolzoni, PT; Chamiot-Clerc, P; Maiorino, M; Pietra, C; Rondelli, I; Simonato, M; Villetti, G, 2003)
" Taken together, the data suggest that acute and chronic administration of ACEA-1328 differentially affected the antinociceptive effect of U50,488H."1.30Effects of ACEA-1328, a NMDA receptor/glycine site antagonist, on U50,488H-induced antinociception and tolerance. ( Doan, P; Lutfy, K; Nguyen, M; Weber, E, 1999)
" The ability of intrathecal glycine and the glycine derivative betaine to reverse strychnine-induced allodynia was also determined using dose-response analysis."1.29Strychnine-dependent allodynia in the urethane-anesthetized rat is segmentally distributed and prevented by intrathecal glycine and betaine. ( Loomis, CW; Sherman, SE, 1995)
"Strychnine induced two types of motor seizures: (1) falling over with tail whipping and (2) convulsions."1.27Prevention of the convulsant and hyperalgesic action of strychnine by intrathecal glycine and related amino acids. ( Banas, C; Beyer, C; Gomora, P; Komisaruk, BR, 1988)
"Skin hyperalgesia persisted for at least 30 minutes in both strychnine and glycine treated rats."1.27Hyperalgesia induced by altered glycinergic activity at the spinal cord. ( Beyer, C; Komisaruk, BR; Roberts, LA, 1985)

Research

Studies (140)

TimeframeStudies, this research(%)All Research%
pre-199012 (8.57)18.7374
1990's20 (14.29)18.2507
2000's73 (52.14)29.6817
2010's32 (22.86)24.3611
2020's3 (2.14)2.80

Authors

AuthorsStudies
Kang, G1
Zhao, M1
Zhang, X1
Peng, L1
Li, C1
Mao, W1
Ye, W1
Peng, S1
Wang, HC1
Cheng, KI1
Tseng, KY1
Kwan, AL1
Chang, LL1
Le, HTN1
Rijal, S1
Jang, SH1
Park, SA1
Park, SJ1
Jung, W1
Han, SK1
Garattini, EG1
Santos, BM1
Ferrari, DP1
Capel, CP1
Francescato, HDC1
Coimbra, TM1
Leite-Panissi, CRA1
Branco, LGS1
Nascimento, GC1
Breitinger, U1
Breitinger, HG1
Honda, K2
Shinoda, M2
Kondo, M1
Shimizu, K1
Yonemoto, H1
Otsuki, K1
Akasaka, R1
Furukawa, A2
Iwata, K2
Villarejo-López, L1
Jiménez, E2
Bartolomé-Martín, D1
Zafra, F2
Lapunzina, P1
Aragón, C2
López-Corcuera, B2
Jiang, YM1
Sun, DD1
Wang, ZG1
Li, T1
Zhao, XL1
Jiao, Y1
Liu, Y1
Li, YJ1
Ouyang, JF1
Wang, DQ1
Schumann-Gillett, A1
O'Mara, ML1
Velasco-Xolalpa, ME1
Barragán-Iglesias, P1
Roa-Coria, JE1
Godínez-Chaparro, B1
Flores-Murrieta, FJ1
Torres-López, JE1
Araiza-Saldaña, CI1
Navarrete, A1
Rocha-González, HI1
Ungard, RG1
Seidlitz, EP1
Singh, G1
Harvey, RJ3
Yee, BK1
Dhaneshwar, S1
Kusurkar, M1
Bodhankar, S1
Bihani, G1
Luz, LL1
Szucs, P1
Safronov, BV1
Palazzo, E5
de Novellis, V4
Rossi, F4
Maione, S5
Koltyn, KF1
Brellenthin, AG1
Cook, DB1
Sehgal, N1
Hillard, C1
Foster, E1
Wildner, H2
Tudeau, L1
Haueter, S1
Ralvenius, WT1
Jegen, M1
Johannssen, H1
Hösli, L1
Haenraets, K1
Ghanem, A1
Conzelmann, KK1
Bösl, M1
Zeilhofer, HU7
Ohashi, N1
Sasaki, M1
Ohashi, M1
Kamiya, Y1
Baba, H1
Kohno, T1
Fu, Y1
Ji, G3
Neugebauer, V3
Palmer, JA1
Higuera, ES1
Chang, L1
Chaplan, SR1
Jiang, P1
Kong, Y1
Zhang, XB1
Wang, W2
Liu, CF1
Xu, TL1
Hermanns, H2
Muth-Selbach, U3
Lipfert, P3
Braun, S1
Werdehausen, R1
Bauer, I2
Stegmann, JU2
Kollosche, K2
Freynhagen, R1
Radhakrishnan, R1
Sluka, KA1
Cheng, W1
Yin, Q1
Cheng, MY1
Chen, HS1
Wang, S1
Feng, T1
Zeng, YM1
Liu, GJ1
Munts, AG1
van der Plas, AA1
Voormolen, JH1
Marinus, J1
Teepe-Twiss, IM1
Onkenhout, W1
van Gerven, JM1
van Hilten, JJ1
Cooke, JE1
Mathers, DA1
Puil, E2
Tůma, P1
Soukupová, M2
Samcová, E1
Stulík, K1
Viisanen, H1
Pertovaara, A1
Edington, AR1
McKinzie, AA1
Reynolds, AJ1
Kassiou, M1
Ryan, RM1
Vandenberg, RJ1
MacLeod, BA1
Wang, JT1
Chung, CC1
Ries, CR1
Schwarz, SK1
Martins, MA1
De Castro Bastos, L1
Melo, NE1
Tonussi, CR1
Lee, IO1
Lim, ES1
Hossaini, M2
Duraku, LS1
Saraç, Ç2
Jongen, JLM1
Holstege, JC2
Pérez-Sen, R1
Delicado, EG1
Miras-Portugal, MT1
Li, Z1
Marabese, I3
Luongo, L2
Boccella, S2
Giordano, C2
Jongen, JL1
Chen, SH1
Tsai, YJ1
Wang, HY1
Lin, CT1
Li, SF1
Lue, JH1
Cao, H2
Ren, WH2
Zhu, MY1
Zhao, ZQ2
Zhang, YQ2
Yamada, MH1
Nishikawa, K1
Kubo, K1
Yanagawa, Y1
Saito, S1
Yévenes, GE1
Tambeli, CH1
Fischer, L1
Monaliza, SL1
Menescal-de-Oliveira, L1
Parada, CA1
Gatta, L1
Vita, D2
Guida, F1
Siniscalco, D1
De Chiaro, M1
Liu, MG1
Matsuura, S1
Suzuki, I1
Shibuta, K1
Tamagawa, T1
Katagiri, A1
Kiyomoto, M1
Ohara, K1
Urata, K1
Lorrain, DS1
Correa, L1
Anderson, J1
Varney, M1
Wang, YX1
Song, LH1
Chen, YZ1
Jiang, CL1
Wallace, MS1
Rowbotham, MC1
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Guo, JD1
Wang, H1
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Sha, H1
Ji, RR1
Lu, VB1
Moran, TD1
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Alier, KA1
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Colmers, WF1
Smith, PA1
Mathiesen, O1
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Di Fabio, R1
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Childers, WE1
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Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Intrathecal Immunoglobulin for Treatment of Adult Patients With Tetanus: a Randomized Controlled 2x2 Factorial Trial[NCT02999815]Phase 1/Phase 2272 participants (Actual)Interventional2017-02-13Completed
A Randomized Controlled Phase II, Two-Arm Study of Umbilical Cord Blood Cell Transplant (MC001) Into Injured Spinal Cord Followed by the Locomotor Training for Patients With Chronic Complete Spinal Cord Injuries (SCI).[NCT03979742]Phase 218 participants (Anticipated)Interventional2022-02-22Recruiting
Phenomics and Genomics of Clinically Relevant Chronic Postsurgical Pain: A Multicenter Prospective Study[NCT04798573]10,000 participants (Anticipated)Observational2012-08-03Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

12 reviews available for glycine and Pain

ArticleYear
Modulators of the Inhibitory Glycine Receptor.
    ACS chemical neuroscience, 2020, 06-17, Volume: 11, Issue:12

    Topics: Analgesics; Glycine; Humans; Pain; Receptors, Glycine; Synaptic Transmission

2020
Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain.
    Nature reviews. Drug discovery, 2013, Volume: 12, Issue:11

    Topics: Alcoholism; Animals; Drugs, Investigational; Glycine; Glycine Plasma Membrane Transport Proteins; Hu

2013
Supraspinal metabotropic glutamate receptor subtype 8: a switch to turn off pain.
    Amino acids, 2014, Volume: 46, Issue:6

    Topics: Animals; Benzoates; Female; Glycine; Humans; Male; Mice, Knockout; Neuroglia; Neurons; Pain; Recepto

2014
Fast synaptic inhibition in spinal sensory processing and pain control.
    Physiological reviews, 2012, Volume: 92, Issue:1

    Topics: Animals; gamma-Aminobutyric Acid; Glycine; Humans; Interneurons; Neurotransmitter Agents; Pain; Post

2012
Advances in pain therapeutics.
    Current opinion in chemical biology, 2003, Volume: 7, Issue:4

    Topics: Anesthetics, Local; Animals; Binding Sites; Glycine; Humans; Molecular Structure; NAV1.9 Voltage-Gat

2003
CHF 3381.
    Drugs in R&D, 2004, Volume: 5, Issue:1

    Topics: Animals; Drugs, Investigational; Glycine; Humans; Indans; Monoamine Oxidase Inhibitors; Pain

2004
Implications of intrathecal pertussis toxin animal model on the cellular mechanisms of neuropathic pain syndrome.
    Acta anaesthesiologica Sinica, 2003, Volume: 41, Issue:4

    Topics: Animals; Disease Models, Animal; Excitatory Amino Acids; Glycine; Hyperalgesia; Injections, Spinal;

2003
Role of cation-chloride-cotransporters (CCC) in pain and hyperalgesia.
    Current topics in medicinal chemistry, 2005, Volume: 5, Issue:6

    Topics: Analgesics; gamma-Aminobutyric Acid; Glycine; Hyperalgesia; K Cl- Cotransporters; Pain; Posterior Ho

2005
Development of pain: maturation of spinal inhibitory networks.
    International anesthesiology clinics, 2007,Spring, Volume: 45, Issue:2

    Topics: Animals; gamma-Aminobutyric Acid; Glycine; Humans; Inhibitory Postsynaptic Potentials; Nerve Net; Pa

2007
N-methyl-D-aspartate antagonists and neuropathic pain: the search for relief.
    Journal of medicinal chemistry, 2007, May-31, Volume: 50, Issue:11

    Topics: Analgesics; Analgesics, Opioid; Animals; Binding Sites; Glycine; Humans; Ion Channel Gating; Pain; P

2007
Indantadol, a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain.
    IDrugs : the investigational drugs journal, 2007, Volume: 10, Issue:9

    Topics: Analgesics; Animals; Anticonvulsants; Clinical Trials as Topic; Diabetic Neuropathies; Glycine; Huma

2007
Loss of glycinergic and GABAergic inhibition in chronic pain--contributions of inflammation and microglia.
    International immunopharmacology, 2008, Volume: 8, Issue:2

    Topics: Animals; Chronic Disease; Dinoprostone; gamma-Aminobutyric Acid; Glycine; Humans; Inflammation; Micr

2008

Trials

7 trials available for glycine and Pain

ArticleYear
Intrathecal glycine for pain and dystonia in complex regional pain syndrome.
    Pain, 2009, Volume: 146, Issue:1-2

    Topics: Adult; Complex Regional Pain Syndromes; Cross-Over Studies; Double-Blind Method; Dystonia; Female; G

2009
A randomized, double-blind, placebo-controlled trial of a glycine antagonist in neuropathic pain.
    Neurology, 2002, Dec-10, Volume: 59, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Double-Blind Method; Female; Glycine; Glycine Agents; Hot Temperatur

2002
Steady-state pharmacokinetics and pharmacodynamics of CHF3381, a novel antineuropathic pain agent, in healthy subjects.
    British journal of clinical pharmacology, 2005, Volume: 59, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Analgesics; Area Under Curve; Attention; Central Nervous Sy

2005
CHF3381, a N-methyl-D-aspartate receptor antagonist and monoamine oxidase-A inhibitor, attenuates secondary hyperalgesia in a human pain model.
    The journal of pain, 2006, Volume: 7, Issue:8

    Topics: Adult; Amines; Analgesics; Capsaicin; Cross-Over Studies; Cyclohexanecarboxylic Acids; Double-Blind

2006
The effect of arginine or glycine supplementation on gastrointestinal function, muscle injury, serum amino acid concentrations and performance during a marathon run.
    International journal of sports medicine, 1999, Volume: 20, Issue:5

    Topics: Adult; Amino Acids; Arginine; Dietary Supplements; Female; Gastrointestinal Hemorrhage; Glycine; Hum

1999
Artificial sweetener reduces nociceptive reaction in term newborn infants.
    Early human development, 2000, Volume: 59, Issue:1

    Topics: Analgesics; Crying; Cyclamates; Female; Glycine; Heart Rate; Humans; Infant, Newborn; Male; Milk, Hu

2000
[First results of the clinical use of injectable lysine acetylsalicylate].
    Minerva medica, 1972, Nov-21, Volume: 63, Issue:83

    Topics: Adult; Aged; Analgesics; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Combinations

1972

Other Studies

121 other studies available for glycine and Pain

ArticleYear
A class of novel conjugates of substituted purine and Gly-AA-OBzl: synthesis and evaluation of orally analgesic activity.
    Bioorganic & medicinal chemistry letters, 2010, Oct-15, Volume: 20, Issue:20

    Topics: Administration, Oral; Analgesics; Animals; Chronic Disease; Glycine; Humans; Male; Mice; Pain; Purin

2010
AAV-glycine receptor α3 alleviates CFA-induced inflammatory pain by downregulating ERK phosphorylation and proinflammatory cytokine expression in SD rats.
    Molecular medicine (Cambridge, Mass.), 2023, 02-15, Volume: 29, Issue:1

    Topics: Animals; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Freund's Adjuvant; Glycine; Human

2023
Inhibitory Effects of Honokiol on Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis in Juvenile Mice.
    Neuroscience, 2023, 06-15, Volume: 521

    Topics: Animals; Glycine; Humans; Mice; Neurons; Neurotransmitter Agents; Pain; Receptors, GABA-A; Substanti

2023
Propargylglycine decreases neuro-immune interaction inducing pain response in temporomandibular joint inflammation model.
    Nitric oxide : biology and chemistry, 2019, 12-01, Volume: 93

    Topics: Alkynes; Animals; Cystathionine gamma-Lyase; Enzyme Inhibitors; Glycine; Hydrogen Sulfide; Hyperalge

2019
Sensitization of TRPV1 and TRPA1 via peripheral mGluR5 signaling contributes to thermal and mechanical hypersensitivity.
    Pain, 2017, Volume: 158, Issue:9

    Topics: Acetanilides; Animals; Disease Models, Animal; Enzyme Inhibitors; Freund's Adjuvant; Glutamic Acid;

2017
P2X receptors up-regulate the cell-surface expression of the neuronal glycine transporter GlyT2.
    Neuropharmacology, 2017, Volume: 125

    Topics: Adenosine Triphosphate; Animals; Brain Stem; Cell Membrane; Cells, Cultured; Cerebral Cortex; Gangli

2017
[Analgesic effect and central mechanisms of CQ prescription on cancer invasion induced mirror image pain in model mice].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2017, Volume: 42, Issue:4

    Topics: Analgesics; Animals; Drugs, Chinese Herbal; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Male; M

2017
Lipid-Based Inhibitors Act Directly on GlyT2.
    ACS chemical neuroscience, 2019, 03-20, Volume: 10, Issue:3

    Topics: Animals; Arachidonic Acids; Biophysical Phenomena; Endocannabinoids; Glycine; Glycine Plasma Membran

2019
Role of hydrogen sulfide in the pain processing of non-diabetic and diabetic rats.
    Neuroscience, 2013, Oct-10, Volume: 250

    Topics: Algorithms; Alkynes; Animals; Blood Glucose; Cystathionine gamma-Lyase; Cysteine; Data Interpretatio

2013
Inhibition of breast cancer-cell glutamate release with sulfasalazine limits cancer-induced bone pain.
    Pain, 2014, Volume: 155, Issue:1

    Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Bone and Bones; Breast

2014
Carrier-linked mutual prodrugs of biphenylacetic acid as a promising alternative to bioprecursor fenbufen: design, kinetics, and pharmacological studies.
    Inflammopharmacology, 2014, Volume: 22, Issue:4

    Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Exper

2014
Peripherally driven low-threshold inhibitory inputs to lamina I local-circuit and projection neurones: a new circuit for gating pain responses.
    The Journal of physiology, 2014, Apr-01, Volume: 592, Issue:7

    Topics: Animals; Electric Stimulation; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glycine;

2014
Mechanisms of exercise-induced hypoalgesia.
    The journal of pain, 2014, Volume: 15, Issue:12

    Topics: Adolescent; Adult; Amides; Arachidonic Acids; Cross-Over Studies; Double-Blind Method; Endocannabino

2014
Targeted ablation, silencing, and activation establish glycinergic dorsal horn neurons as key components of a spinal gate for pain and itch.
    Neuron, 2015, Mar-18, Volume: 85, Issue:6

    Topics: Animals; Disease Models, Animal; Glycine; Hyperalgesia; Mice; Mice, Transgenic; Nerve Net; Neurons;

2015
Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn.
    Scientific reports, 2015, Aug-21, Volume: 5

    Topics: Animals; Behavior, Animal; Biomarkers; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases

2015
Group III mGluR7 and mGluR8 in the amygdala differentially modulate nocifensive and affective pain behaviors.
    Neuropharmacology, 2008, Volume: 55, Issue:4

    Topics: Amygdala; Animals; Arthritis; Behavior, Animal; Benzhydryl Compounds; Benzoates; Disease Models, Ani

2008
Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse.
    Neuroscience, 2008, Jul-17, Volume: 154, Issue:4

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Burns; Cannabinoid Receptor Modulators; Disease Models,

2008
Glycine receptor in rat hippocampal and spinal cord neurons as a molecular target for rapid actions of 17-beta-estradiol.
    Molecular pain, 2009, Jan-12, Volume: 5

    Topics: Animals; Cells, Cultured; Electrophysiology; Estradiol; Female; Glycine; Hippocampus; Male; Neurons;

2009
Loss of spinal glycinergic neurons is not necessary for development of neuropathic pain in transgenic mice expressing enhanced green fluorescent protein in glycinergic neurons.
    Neuroscience, 2009, Mar-31, Volume: 159, Issue:3

    Topics: Analysis of Variance; Animals; Cell Count; Cell Death; Chromosomes, Artificial, Bacterial; Constrict

2009
Antinociceptive effects of systemic lidocaine: involvement of the spinal glycinergic system.
    European journal of pharmacology, 2009, Jun-24, Volume: 613, Issue:1-3

    Topics: Analgesics; Animals; Binding Sites; Glycine; Glycine Agents; Lidocaine; Organophosphonates; Pain; Qu

2009
Increased glutamate and decreased glycine release in the rostral ventromedial medulla during induction of a pre-clinical model of chronic widespread muscle pain.
    Neuroscience letters, 2009, Jul-03, Volume: 457, Issue:3

    Topics: Acids; Analysis of Variance; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Disease M

2009
Intracerebroventricular or intrathecal injection of glycine produces analgesia in thermal nociception and chemical nociception via glycine receptors.
    European journal of pharmacology, 2009, Jul-01, Volume: 614, Issue:1-3

    Topics: Acetic Acid; Analgesia; Analgesics; Animals; Behavior, Animal; Female; Glycine; Hot Temperature; Inj

2009
Isovaline causes inhibition by increasing potassium conductance in thalamic neurons.
    Neuroscience, 2009, Dec-15, Volume: 164, Issue:3

    Topics: Action Potentials; Analgesics; Animals; Animals, Newborn; Calcium Signaling; Dose-Response Relations

2009
A determination of submicromolar concentrations of glycine in periaqueductal gray matter microdialyzates using capillary zone electrophoresis with contactless conductivity detection.
    Electrophoresis, 2009, Volume: 30, Issue:19

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carrageenan; Electric Conductivity; Electrophoresi

2009
Antinociception by motor cortex stimulation in the neuropathic rat: does the locus coeruleus play a role?
    Experimental brain research, 2010, Volume: 201, Issue:2

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Anesthetics, Local; Animals;

2010
Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport.
    The Journal of biological chemistry, 2009, Dec-25, Volume: 284, Issue:52

    Topics: Animals; Arachidonic Acids; Biological Transport; Glycine; Glycine Plasma Membrane Transport Protein

2009
Analgesic properties of the novel amino acid, isovaline.
    Anesthesia and analgesia, 2010, Apr-01, Volume: 110, Issue:4

    Topics: Acute Disease; Analgesics, Non-Narcotic; Animals; beta-Alanine; Chronic Disease; Cisterna Magna; Fem

2010
Dependency of nociception facilitation or inhibition after periaqueductal gray matter stimulation on the context.
    Behavioural brain research, 2010, Dec-25, Volume: 214, Issue:2

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde;

2010
Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice.
    Acta pharmacologica Sinica, 2010, Volume: 31, Issue:8

    Topics: Animals; Bicuculline; Disease Models, Animal; Glycine; Hot Temperature; Hyperalgesia; Injections; In

2010
Differential distribution of activated spinal neurons containing glycine and/or GABA and expressing c-fos in acute and chronic pain models.
    Pain, 2010, Volume: 151, Issue:2

    Topics: Animals; Capsaicin; Cell Count; Disease Models, Animal; Formaldehyde; gamma-Aminobutyric Acid; Gene

2010
P2Y purinergic regulation of the glycine neurotransmitter transporters.
    The Journal of biological chemistry, 2011, Mar-25, Volume: 286, Issue:12

    Topics: Adenosine Diphosphate; Animals; Brain Stem; Cells, Cultured; Cyclic GMP-Dependent Protein Kinases; E

2011
Mitochondrial reactive oxygen species are activated by mGluR5 through IP3 and activate ERK and PKA to increase excitability of amygdala neurons and pain behavior.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Jan-19, Volume: 31, Issue:3

    Topics: Amygdala; Analysis of Variance; Animals; Antioxidants; Benzoates; Cyclic AMP-Dependent Protein Kinas

2011
Metabotropic glutamate receptor subtype 8 in the amygdala modulates thermal threshold, neurotransmitter release, and rostral ventromedial medulla cell activity in inflammatory pain.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Mar-23, Volume: 31, Issue:12

    Topics: Amino Acids; Amygdala; Animals; Behavior, Animal; Benzoates; Blotting, Western; Carrageenan; Chromat

2011
Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABA(A) receptors.
    Journal of neurophysiology, 2011, Volume: 106, Issue:5

    Topics: Action Potentials; Animals; Arthritis, Experimental; Benzoates; Bicuculline; Disease Models, Animal;

2011
Spinal glycinergic and GABAergic neurons expressing C-fos after capsaicin stimulation are increased in rats with contralateral neuropathic pain.
    Neuroscience, 2011, Nov-24, Volume: 196

    Topics: Animals; Capsaicin; Freund's Adjuvant; Functional Laterality; GABAergic Neurons; Glycine; Inflammati

2011
Decreases of glycine receptor expression induced by median nerve injury in the rat cuneate nucleus contribute to NPY release and c-Fos expression.
    Life sciences, 2012, Feb-13, Volume: 90, Issue:7-8

    Topics: Animals; Gene Expression Regulation; Glycine; Immunohistochemistry; Median Nerve; Medulla Oblongata;

2012
Activation of glycine site and GluN2B subunit of NMDA receptors is necessary for ERK/CREB signaling cascade in rostral anterior cingulate cortex in rats: implications for affective pain.
    Neuroscience bulletin, 2012, Volume: 28, Issue:1

    Topics: Animals; Cyclic AMP Response Element-Binding Protein; Extracellular Signal-Regulated MAP Kinases; Gl

2012
Impaired glycinergic synaptic transmission and enhanced inflammatory pain in mice with reduced expression of vesicular GABA transporter (VGAT).
    Molecular pharmacology, 2012, Volume: 81, Issue:4

    Topics: Animals; Behavior, Animal; Blotting, Western; Down-Regulation; Glycine; Inflammation; Mice; Mice, Kn

2012
The functional role of ascending nociceptive control in defensive behavior.
    Brain research, 2012, Jun-29, Volume: 1464

    Topics: Animals; Benzoates; Excitatory Amino Acid Antagonists; Glycine; Immobility Response, Tonic; Male; Mo

2012
Role of metabotropic glutamate receptor 1 in the basolateral amygdala-driven prefrontal cortical deactivation in inflammatory pain in the rat.
    Neuropharmacology, 2013, Volume: 66

    Topics: Action Potentials; Amygdala; Animals; Bicuculline; Carrageenan; Chromones; Disease Models, Animal; E

2013
Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord.
    Journal of neuroinflammation, 2012, Nov-27, Volume: 9

    Topics: Analysis of Variance; Animals; Disease Models, Animal; Electromyography; Enzyme Inhibitors; Excitato

2012
Activation of spinal group I metabotropic glutamate receptors in rats evokes local glutamate release and spontaneous nociceptive behaviors: effects of 2-methyl-6-(phenylethynyl)-pyridine pretreatment.
    Neuroscience letters, 2002, Jul-26, Volume: 327, Issue:3

    Topics: Animals; Behavior, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extrac

2002
The analgesic domain of interferon-alpha2b contains an essential proline(39) residue.
    Neuroimmunomodulation, 2002, Volume: 10, Issue:1

    Topics: Analgesics; Animals; Brain; Glycine; Humans; Interferon alpha-2; Interferon-alpha; Male; Molecular S

2002
Bicuculline and strychnine suppress the mesencephalic locomotor region-induced inhibition of group III muscle afferent input to the dorsal horn.
    Neuroscience, 2003, Volume: 118, Issue:3

    Topics: Afferent Pathways; Animals; Bicuculline; Cats; Efferent Pathways; Female; GABA Antagonists; GABA-A R

2003
Antinociceptive activity of the N-methyl-D-aspartate receptor antagonist N-(2-Indanyl)-glycinamide hydrochloride (CHF3381) in experimental models of inflammatory and neuropathic pain.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 306, Issue:2

    Topics: Animals; Carrageenan; Cold Temperature; Diabetes Mellitus; Disease Models, Animal; Drug Tolerance; E

2003
Salt and wounds: a new mechanism for neuropathic pain.
    Nature medicine, 2003, Volume: 9, Issue:9

    Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glycine; Humans; K Cl- Cotransporters; Ner

2003
Symptom patterns and pathophysiological mechanisms in dyspeptic patients with and without Helicobacter pylori.
    Digestive diseases and sciences, 2003, Volume: 48, Issue:12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Breath Tests; Caprylates; Carbon Radioisotopes; Dyspepsi

2003
Retargeted clostridial endopeptidases: inhibition of nociceptive neurotransmitter release in vitro, and antinociceptive activity in in vivo models of pain.
    Movement disorders : official journal of the Movement Disorder Society, 2004, Volume: 19 Suppl 8

    Topics: Action Potentials; Animals; Botulinum Toxins, Type A; Cells, Cultured; Disease Models, Animal; Dose-

2004
Neuroscience. Locating a new step in pain's pathway.
    Science (New York, N.Y.), 2004, May-07, Volume: 304, Issue:5672

    Topics: Animals; Dinoprostone; Glycine; Inflammation; Mice; Mice, Knockout; Neurons; Pain; Receptors, Glycin

2004
GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization.
    Science (New York, N.Y.), 2004, May-07, Volume: 304, Issue:5672

    Topics: Amino Acid Sequence; Animals; Cell Line; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Female;

2004
Nicotine differentially activates inhibitory and excitatory neurons in the dorsal spinal cord.
    Pain, 2004, Volume: 109, Issue:3

    Topics: Action Potentials; Afferent Pathways; Analgesics; Animals; Biomarkers; Calbindins; Dendrites; Excita

2004
Electrophysiological characterization of N-methyl-D-aspartate receptors in rat dorsal root ganglia neurons.
    Pain, 2004, Volume: 109, Issue:3

    Topics: Animals; Calcium; Calcium Signaling; Cells, Cultured; Colon; Dose-Response Relationship, Drug; Excit

2004
Adenosine inhibits GABAergic and glycinergic transmission in adult rat substantia gelatinosa neurons.
    Journal of neurophysiology, 2004, Volume: 92, Issue:5

    Topics: 4-Aminopyridine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; Colforsin; GABA Antagon

2004
The spinal antinociceptive effect of nocistatin in neuropathic rats is blocked by D-serine.
    Anesthesiology, 2004, Volume: 101, Issue:3

    Topics: Analgesics, Opioid; Anesthesia, Spinal; Animals; Dose-Response Relationship, Drug; Glycine; Hyperalg

2004
An antisense oligonucleotide to the N-methyl-D-aspartate (NMDA) subunit NMDAR1 attenuates NMDA-induced nociception, hyperalgesia, and morphine tolerance.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:2

    Topics: Analgesics, Opioid; Animals; Autoradiography; Behavior, Animal; Dose-Response Relationship, Drug; Dr

2005
Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype.
    The Journal of clinical investigation, 2005, Volume: 115, Issue:3

    Topics: Animals; Behavior, Animal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors;

2005
Effect of morphine on deep dorsal horn projection neurons depends on spinal GABAergic and glycinergic tone: implications for reduced opioid effect in neuropathic pain.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 315, Issue:2

    Topics: Administration, Topical; Analgesics, Opioid; Animals; Behavior, Animal; Electrophysiology; gamma-Ami

2005
Morphological evidence for GABA/glycine-cocontaining terminals in synaptic contact with neurokinin-1 receptor-expressing neurons in the sacral dorsal commissural nucleus of the rat.
    Neuroscience letters, 2005, Nov-18, Volume: 388, Issue:3

    Topics: Animals; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glycine;

2005
CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats.
    European journal of pharmacology, 2005, Sep-20, Volume: 519, Issue:3

    Topics: Administration, Oral; Amines; Analgesics; Animals; Behavior, Animal; Capsaicin; Cyclohexanecarboxyli

2005
Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect?
    Journal of neurochemistry, 2006, Volume: 96, Issue:6

    Topics: Animals; Anxiety; D-Amino-Acid Oxidase; Excitatory Amino Acid Antagonists; Fear; Glycine; Gyrus Cing

2006
Substantia Gelatinosa neurons in defined-medium organotypic slice culture are similar to those in acute slices from young adult rats.
    Pain, 2006, Volume: 121, Issue:3

    Topics: Action Potentials; Afferent Pathways; Aging; Animals; Chronic Disease; Culture Media; Electric Stimu

2006
Design and characterization of a noncompetitive antagonist of the transient receptor potential vanilloid subunit 1 channel with in vivo analgesic and anti-inflammatory activity.
    The journal of pain, 2006, Volume: 7, Issue:10

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arginine; Capsaicin; Chlorocebus aethiops; COS Cells;

2006
Intracellular messengers involved in spontaneous pain, heat hyperalgesia, and mechanical allodynia induced by intrathecal dihydroxyphenylglycine.
    Neuroscience letters, 2006, Dec-06, Volume: 409, Issue:3

    Topics: Animals; Extracellular Signal-Regulated MAP Kinases; Glycine; Hot Temperature; Hyperalgesia; Hyperes

2006
Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice.
    Neuropharmacology, 2007, Volume: 52, Issue:2

    Topics: Analysis of Variance; Animals; Benzhydryl Compounds; Benzoates; Carrageenan; Dinucleoside Phosphates

2007
Subarachnoid transplant of a human neuronal cell line attenuates chronic allodynia and hyperalgesia after excitotoxic spinal cord injury in the rat.
    The journal of pain, 2007, Volume: 8, Issue:1

    Topics: Animals; Antimetabolites; Bromodeoxyuridine; Cell Differentiation; Cell Line; Cell Transplantation;

2007
Chiral tetrahydroquinoline derivatives as potent anti-hyperalgesic agents in animal models of sustained inflammation and chronic neuropathic pain.
    Bioorganic & medicinal chemistry letters, 2007, Mar-01, Volume: 17, Issue:5

    Topics: Animals; Biological Availability; Disease Models, Animal; Glycine; Hydroquinones; Hyperalgesia; Infl

2007
Decrease in N-methyl-D-aspartic acid receptor-NR2B subunit levels by intrathecal short-hairpin RNA blocks group I metabotropic glutamate receptor-mediated hyperalgesia.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:1

    Topics: Animals; Excitatory Amino Acid Antagonists; Gene Silencing; Glycine; Hyperalgesia; Male; Mice; Pain;

2007
BDNF-mediated modulation of GABA and glycine release in dorsal horn lamina II from postnatal rats.
    Developmental neurobiology, 2007, Volume: 67, Issue:7

    Topics: Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Dendrites; gamma-Aminobutyric Acid; Gl

2007
Role of spinal metabotropic glutamate receptor subtype 5 in the development of tolerance to morphine-induced antinociception in rat.
    Neuroscience letters, 2007, Jun-13, Volume: 420, Issue:2

    Topics: Analgesics, Opioid; Animals; Calcium; Drug Administration Schedule; Drug Tolerance; Excitatory Amino

2007
Enhanced 3,5-dihydroxyphenylglycine-induced sustained nociceptive behaviors in rats with neuropathy or chronic inflammation.
    Behavioural brain research, 2007, Dec-03, Volume: 184, Issue:2

    Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Excitatory Amino Acid Agoni

2007
A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore.
    Journal of neurochemistry, 2007, Volume: 103, Issue:2

    Topics: Data Interpretation, Statistical; DNA, Complementary; Electrophysiology; Glycine; Humans; Hydrogen B

2007
Actions of N-arachidonyl-glycine in a rat inflammatory pain model.
    Molecular pain, 2007, Aug-30, Volume: 3

    Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Disease Models, Animal; Glycine; Inflamma

2007
Glycine inhibitory dysfunction turns touch into pain through PKCgamma interneurons.
    PloS one, 2007, Nov-07, Volume: 2, Issue:11

    Topics: Animals; Glycine; Interneurons; Male; Pain; Protein Kinase C; Rats; Rats, Sprague-Dawley

2007
mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo.
    Brain research, 2008, Jan-02, Volume: 1187

    Topics: Analgesics, Opioid; Animals; Calcium Signaling; Central Nervous System; Dose-Response Relationship,

2008
Increased C-fiber nociceptive input potentiates inhibitory glycinergic transmission in the spinal dorsal horn.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 324, Issue:3

    Topics: Animals; Capsaicin; Glycine; Inhibitory Postsynaptic Potentials; Male; Nerve Fibers, Unmyelinated; N

2008
A nociceptive-intensity-dependent role for hydrogen sulphide in the formalin model of persistent inflammatory pain.
    Neuroscience, 2008, Mar-03, Volume: 152, Issue:1

    Topics: Alkynes; Animals; Enzyme Inhibitors; Formaldehyde; Glycine; Hydrogen Sulfide; Inflammation; Irritant

2008
Glycine transporter inhibitors as a potential therapeutic strategy for chronic pain with memory impairment.
    Anesthesiology, 2008, Volume: 108, Issue:5

    Topics: Acute Disease; Analgesics; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Glycine;

2008
Expression of adenosine A 2A receptors in the rat lumbar spinal cord and implications in the modulation of N-methyl-d-aspartate receptor currents.
    Anesthesia and analgesia, 2008, Volume: 106, Issue:6

    Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Blotting, Western; Glycine; Lumbosacral Region;

2008
Ronald Tasker Award: Intrathecal transplantation of a human neuronal cell line for the treatment of neuropathic pain in a spinal cord injury model.
    Clinical neurosurgery, 2007, Volume: 54

    Topics: Animals; Carcinoma, Embryonal; Cell Line, Tumor; gamma-Aminobutyric Acid; Glycine; Injections, Spina

2007
Transmitters involved in central processing of nociceptive information.
    Anaesthesia and intensive care, 1982, Volume: 10, Issue:2

    Topics: Animals; Enkephalins; gamma-Aminobutyric Acid; Glycine; Humans; Neural Inhibition; Neurons, Afferent

1982
Antinociceptive effect of systemic PC 12, a prodrug mixed inhibitor of enkephalin-degrading enzymes, in normal and arthritic rats.
    European journal of pharmacology, 1993, Sep-07, Volume: 241, Issue:1

    Topics: Aminopeptidases; Analgesics; Animals; Arthritis, Experimental; CD13 Antigens; Dose-Response Relation

1993
Glycine and GABAA antagonists reduce the inhibition of primate spinothalamic tract neurons produced by stimulation in periaqueductal gray.
    Brain research, 1994, Aug-22, Volume: 654, Issue:2

    Topics: Animals; Bicuculline; Brain Mapping; Dose-Response Relationship, Drug; Electric Stimulation; GABA-A

1994
Effects of intrathecal strychnine and bicuculline on nerve compression-induced thermal hyperalgesia and selective antagonism by MK-801.
    Pain, 1993, Volume: 54, Issue:1

    Topics: Animals; Bicuculline; Dizocilpine Maleate; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid

1993
(+)-HA 966, a partial agonist at the glycine site coupled to NMDA receptors, blocks formalin-induced pain in mice.
    European journal of pharmacology, 1993, Jul-20, Volume: 238, Issue:2-3

    Topics: Animals; Formaldehyde; Glycine; Hindlimb; Male; Mice; Pain; Pyrrolidinones; Receptors, N-Methyl-D-As

1993
Prostaglandin D2 inhibits prostaglandin E2-induced allodynia in conscious mice.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:3

    Topics: Adrenergic Agonists; Animals; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; gamma-Amino

1996
Strychnine-dependent allodynia in the urethane-anesthetized rat is segmentally distributed and prevented by intrathecal glycine and betaine.
    Canadian journal of physiology and pharmacology, 1995, Volume: 73, Issue:12

    Topics: Anesthetics, Intravenous; Animals; Betaine; Evoked Potentials, Somatosensory; Glycine; Glycine Agent

1995
The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception.
    Pain, 1996, Volume: 68, Issue:2-3

    Topics: Aminobutyrates; Analysis of Variance; Animals; Benzoates; Cycloleucine; Cyclopropanes; Excitatory Am

1996
Inhibition of nociceptin-induced allodynia in conscious mice by prostaglandin D2.
    British journal of pharmacology, 1997, Volume: 122, Issue:4

    Topics: Animals; Bucladesine; Dibutyryl Cyclic GMP; Glycine; Hyperalgesia; Male; Mice; Narcotic Antagonists;

1997
Behavioural and electrophysiological evidence supporting a role for group I metabotropic glutamate receptors in the mediation of nociceptive inputs to the rat spinal cord.
    Brain research, 1997, Nov-28, Volume: 777, Issue:1-2

    Topics: Alanine; Animals; Antihypertensive Agents; Behavior, Animal; Benzothiadiazines; Cycloleucine; Electr

1997
[Preemptive analgesia].
    Masui. The Japanese journal of anesthesiology, 1997, Volume: 46 Suppl

    Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; Formaldehyde; GABA Antagonists; gamma-Aminob

1997
In vivo antinociceptive activity of anti-rat mGluR1 and mGluR5 antibodies in rats.
    Neuroreport, 1998, Mar-09, Volume: 9, Issue:4

    Topics: Analgesics; Animals; Excitatory Amino Acid Antagonists; Glycine; Immunoglobulin G; Injections, Spina

1998
Involvement of the central tachykinin NK1 receptor during maintenance of mechanical hypersensitivity induced by diabetes in the rat.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 285, Issue:3

    Topics: Animals; Benzofurans; Carbamates; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Electrophy

1998
Inflammation alters the effects of mGlu receptor agonists on spinal nociceptive neurones.
    European journal of pharmacology, 1998, Apr-24, Volume: 347, Issue:2-3

    Topics: Animals; Carrageenan; Cycloleucine; Excitatory Amino Acid Antagonists; Glycine; Inflammation; Male;

1998
Effects of NMDA receptor antagonists on nociceptive responses in vivo: comparison of antagonists acting at the glycine site with uncompetitive antagonists.
    Amino acids, 1998, Volume: 14, Issue:1-3

    Topics: Animals; Decerebrate State; Excitatory Amino Acid Antagonists; Glycine; Male; Pain; Phthalazines; Ra

1998
The antinociceptive effect of combined systemic administration of morphine and the glycine/NMDA receptor antagonist, (+)-HA966 in a rat model of peripheral neuropathy.
    British journal of pharmacology, 1998, Volume: 125, Issue:8

    Topics: Analgesics, Opioid; Animals; Binding Sites; Cold Temperature; Disease Models, Animal; Dose-Response

1998
Effects of ACEA-1328, a NMDA receptor/glycine site antagonist, on U50,488H-induced antinociception and tolerance.
    European journal of pharmacology, 1999, Nov-12, Volume: 384, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics

1999
Evaluation of the activity of a novel metabotropic glutamate receptor antagonist (+/-)-2-amino-2-(3-cis and trans-carboxycyclobutyl-3-(9-thioxanthyl)propionic acid) in the in vitro neonatal spinal cord and in an in vivo pain model.
    Neuroscience, 2000, Volume: 95, Issue:3

    Topics: Acetic Acid; Animals; Animals, Newborn; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antag

2000
Long-term intrathecal administration of glycine prevents mechanical hyperalgesia in a rat model of neuropathic pain.
    Neurological research, 2000, Volume: 22, Issue:2

    Topics: Animals; Glycine; Hyperalgesia; Injections, Spinal; Ligation; Male; Mechanoreceptors; Nervous System

2000
Induction of homosynaptic long-term depression at spinal synapses of sensory a delta-fibers requires activation of metabotropic glutamate receptors.
    Neuroscience, 2000, Volume: 98, Issue:1

    Topics: Animals; Benzoates; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic

2000
Electrophysiologic evidence for increased endogenous gabaergic but not glycinergic inhibitory tone in the rat spinal nerve ligation model of neuropathy.
    Anesthesiology, 2001, Volume: 94, Issue:2

    Topics: Animals; Bicuculline; Cold Temperature; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; G

2001
Peripheral group I metabotropic glutamate receptors modulate nociception in mice.
    Nature neuroscience, 2001, Volume: 4, Issue:4

    Topics: Animals; Chromones; Excitatory Amino Acid Antagonists; Glycine; Hindlimb; Hot Temperature; Immunohis

2001
Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain.
    The Journal of biological chemistry, 2001, Nov-16, Volume: 276, Issue:46

    Topics: Alanine; Amidohydrolases; Amino Acids; Animals; Arachidonic Acid; Arachidonic Acids; Brain; Calcium;

2001
Metabotropic glutamate 1alpha receptors on peripheral primary afferent fibers: their role in nociception.
    Brain research, 2001, Sep-14, Volume: 913, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excita

2001
GV196771A, an NMDA receptor/glycine site antagonist, attenuates mechanical allodynia in neuropathic rats and reduces tolerance induced by morphine in mice.
    European journal of pharmacology, 2001, Nov-02, Volume: 430, Issue:2-3

    Topics: Animals; Behavior, Animal; Binding Sites; Constriction, Pathologic; Disease Models, Animal; Dose-Res

2001
Synaptic connections between trigemino-parabrachial projection neurons and gamma-aminobutyric acid- and glycine-immunoreactive terminals in the rat.
    Brain research, 2001, Dec-07, Volume: 921, Issue:1-2

    Topics: Animals; Dendrites; gamma-Aminobutyric Acid; Glycine; Horseradish Peroxidase; Immunohistochemistry;

2001
PGE(2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons.
    Nature neuroscience, 2002, Volume: 5, Issue:1

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cholera Toxin; Cyclic AMP-Depende

2002
Group I metabotropic glutamate receptors in spinal cord injury: roles in neuroprotection and the development of chronic central pain.
    Journal of neurotrauma, 2002, Volume: 19, Issue:1

    Topics: Animals; Benzoates; Chronic Disease; Excitatory Amino Acid Antagonists; Glycine; Hyperalgesia; Locom

2002
Attenuation of thermal nociception and hyperalgesia by VR1 blockers.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Feb-19, Volume: 99, Issue:4

    Topics: Animals; Calcium; Capsaicin; Dose-Response Relationship, Drug; Electrophysiology; Glycine; Hot Tempe

2002
Investigation of a pain syndrome of spinal origin (on the concept of the generator mechanism of the pain syndrome).
    Bulletin of experimental biology and medicine, 1975, Volume: 77, Issue:7

    Topics: Animals; Denervation; Glycine; Hindlimb; Neural Inhibition; Neurons, Afferent; Pain; Rats; Spinal Co

1975
Light and electron microscope study of GABA-immunoreactive neurones in lamina III of rat spinal cord.
    The Journal of comparative neurology, 1992, Jan-08, Volume: 315, Issue:2

    Topics: Animals; gamma-Aminobutyric Acid; Glycine; Male; Microscopy, Electron; Neurons; Neurons, Afferent; P

1992
Modulation of neuropathic pain behavior in rats by spinal disinhibition and NMDA receptor blockade of injury discharge.
    Pain, 1991, Volume: 45, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Dizocilpine Maleate; Electric Stimulation; G

1991
Influence of glycine on morphine-induced antinociception in mice.
    European journal of pharmacology, 1990, Apr-25, Volume: 179, Issue:3

    Topics: Acetylcholine; Analgesics; Animals; Behavior, Animal; Drug Synergism; Female; Glycine; Hot Temperatu

1990
Blockage of substance P-induced scratching behavior in rats by the intrathecal administration of inhibitory amino acid agonists.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 34, Issue:3

    Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Glycine; Injections, Spinal; Mu

1989
Novel inhibitors of enkephalin-degrading enzymes. II: N5'-substituted-4-thioxohydantoic acids as aminopeptidase inhibitors.
    Journal of enzyme inhibition, 1989, Volume: 3, Issue:2

    Topics: Aminopeptidases; Analgesics; Animals; Glycine; Indicators and Reagents; Leucine; Mice; Naloxone; Nep

1989
Prevention of the convulsant and hyperalgesic action of strychnine by intrathecal glycine and related amino acids.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 29, Issue:1

    Topics: Alanine; Amino Acids; Animals; Betaine; Glycine; Injections, Spinal; Pain; Rats; Rats, Inbred Strain

1988
Hyperalgesia induced by altered glycinergic activity at the spinal cord.
    Life sciences, 1985, Sep-02, Volume: 37, Issue:9

    Topics: Animals; Behavior, Animal; Castration; Female; Glycine; Hyperalgesia; Hyperesthesia; Injections, Spi

1985
[The value of avafortan in a general surgery service].
    Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille, 1971, Volume: 16

    Topics: Adult; Aged; Alkanesulfonates; Analgesics; Antipyrine; Ethylamines; Female; Glycine; Humans; Male; M

1971
[Experimental trigeminal neuralgia (with reference to the concept of the generator mechanism of the pain syndrome)].
    Biulleten' eksperimental'noi biologii i meditsiny, 1974, Volume: 78, Issue:11

    Topics: Animals; Disease Models, Animal; Electromyography; Facial Muscles; Glycine; Neural Inhibition; Pain;

1974
[Study of the pain syndrome of spinal origin (the concept of a generative mechanism for the pain syndrome)].
    Biulleten' eksperimental'noi biologii i meditsiny, 1974, Volume: 78, Issue:7

    Topics: Animals; Denervation; Femoral Nerve; Glycine; Injections, Spinal; Lumbosacral Plexus; Neural Inhibit

1974
[Experiences with Ambene in gynecological practice].
    Munchener medizinische Wochenschrift (1950), 1972, May-19, Volume: 114, Issue:20

    Topics: Adolescent; Adult; Aluminum; Dexamethasone; Drug Combinations; Female; Genital Diseases, Female; Gly

1972
[Value of Avafortan sugar-coated pills in the treatment of pain in gynecology].
    Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille, 1971, Volume: 16, Issue:10

    Topics: Antipyrine; Female; Genital Diseases, Female; Glycine; Humans; Methylamines; Pain; Parasympatholytic

1971