Compounds > neurokinin b
Page last updated: 2024-09-23

neurokinin b

Description

Neurokinin B: A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ A with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the URINARY BLADDER and UTERUS. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5311312
CHEMBL ID437797
CHEBI ID80312
MeSH IDM0023534

Synonyms (19)

Synonym
(nkb)asp-met-his-asp-phe-phe-val-gly-leu-met-nh2
asp-met-his-asp-phe-phe-val-gly-leu-met-nh2(neurokinin b)
bdbm50079412
NKB ,
gtpl2090
tachykinin-3
neuromedin k
neurokinin b
neurokinin k
chebi:80312 ,
CHEMBL437797 ,
86933-75-7
asp-met-his-asp-phe-phe-val-gly-leu-met-nh2
neurokinin b (human, porcine) ,
AKOS024456682
SR-05000014260-1
sr-05000014260
DTXSID4040890
AS-83342

Drug Classes (1)

ClassDescription
polypeptideA peptide containing ten or more amino acid residues.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (8)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Substance-K receptorHomo sapiens (human)IC50 (µMol)0.10230.00013.12109.5530AID211880
Substance-K receptorHomo sapiens (human)Ki0.02900.00011.92429.7930AID1203262; AID211879
Substance-P receptorHomo sapiens (human)IC50 (µMol)0.09800.00000.09526.8130AID208431
Substance-P receptorHomo sapiens (human)Ki0.50120.00000.79368.7470AID1203183
Neuromedin-K receptorHomo sapiens (human)IC50 (µMol)0.02960.00100.28822.9900AID145629; AID212235; AID738397
Neuromedin-K receptorHomo sapiens (human)Ki0.00080.00020.05430.9250AID1203261
Neuromedin-K receptorCavia porcellus (domestic guinea pig)IC50 (µMol)0.00200.00200.00700.0120AID212079
Substance-K receptorMesocricetus auratus (golden hamster)IC50 (µMol)0.01080.00100.03530.1480AID211530; AID211537
Substance-K receptorOryctolagus cuniculus (rabbit)Ki0.04220.00070.04830.1020AID211879
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Neuromedin-K receptorRattus norvegicus (Norway rat)EC50 (µMol)0.00630.00051.61667.5000AID212383
Substance-K receptorRattus norvegicus (Norway rat)EC50 (µMol)0.02700.00050.49643.1300AID211909
Neuromedin-K receptorHomo sapiens (human)EC50 (µMol)0.00600.00020.08960.7930AID145627
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (49)

Processvia Protein(s)Taxonomy
muscle contractionSubstance-K receptorHomo sapiens (human)
tachykinin receptor signaling pathwaySubstance-K receptorHomo sapiens (human)
positive regulation of acetylcholine secretion, neurotransmissionSubstance-K receptorHomo sapiens (human)
intestine smooth muscle contractionSubstance-K receptorHomo sapiens (human)
negative regulation of luteinizing hormone secretionSubstance-K receptorHomo sapiens (human)
operant conditioningSubstance-K receptorHomo sapiens (human)
positive regulation of vascular permeabilitySubstance-K receptorHomo sapiens (human)
positive regulation of monoatomic ion transportSubstance-K receptorHomo sapiens (human)
positive regulation of smooth muscle contractionSubstance-K receptorHomo sapiens (human)
response to electrical stimulusSubstance-K receptorHomo sapiens (human)
prolactin secretionSubstance-K receptorHomo sapiens (human)
positive regulation of uterine smooth muscle contractionSubstance-K receptorHomo sapiens (human)
positive regulation of flagellated sperm motilitySubstance-K receptorHomo sapiens (human)
aggressive behaviorSubstance-P receptorHomo sapiens (human)
positive regulation of leukocyte migrationSubstance-P receptorHomo sapiens (human)
angiotensin-mediated drinking behaviorSubstance-P receptorHomo sapiens (human)
inflammatory responseSubstance-P receptorHomo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathwaySubstance-P receptorHomo sapiens (human)
positive regulation of cytosolic calcium ion concentrationSubstance-P receptorHomo sapiens (human)
tachykinin receptor signaling pathwaySubstance-P receptorHomo sapiens (human)
long-term memorySubstance-P receptorHomo sapiens (human)
associative learningSubstance-P receptorHomo sapiens (human)
detection of abiotic stimulusSubstance-P receptorHomo sapiens (human)
response to ozoneSubstance-P receptorHomo sapiens (human)
positive regulation of epithelial cell migrationSubstance-P receptorHomo sapiens (human)
response to auditory stimulusSubstance-P receptorHomo sapiens (human)
regulation of smooth muscle cell migrationSubstance-P receptorHomo sapiens (human)
positive regulation of synaptic transmission, cholinergicSubstance-P receptorHomo sapiens (human)
positive regulation of synaptic transmission, GABAergicSubstance-P receptorHomo sapiens (human)
response to estradiolSubstance-P receptorHomo sapiens (human)
response to progesteroneSubstance-P receptorHomo sapiens (human)
response to nicotineSubstance-P receptorHomo sapiens (human)
operant conditioningSubstance-P receptorHomo sapiens (human)
sperm ejaculationSubstance-P receptorHomo sapiens (human)
eating behaviorSubstance-P receptorHomo sapiens (human)
positive regulation of vascular permeabilitySubstance-P receptorHomo sapiens (human)
response to ethanolSubstance-P receptorHomo sapiens (human)
positive regulation of action potentialSubstance-P receptorHomo sapiens (human)
positive regulation of blood pressureSubstance-P receptorHomo sapiens (human)
positive regulation of ossificationSubstance-P receptorHomo sapiens (human)
positive regulation of vasoconstrictionSubstance-P receptorHomo sapiens (human)
positive regulation of hormone secretionSubstance-P receptorHomo sapiens (human)
behavioral response to painSubstance-P receptorHomo sapiens (human)
regulation of smooth muscle cell proliferationSubstance-P receptorHomo sapiens (human)
positive regulation of lymphocyte proliferationSubstance-P receptorHomo sapiens (human)
positive regulation of epithelial cell proliferationSubstance-P receptorHomo sapiens (human)
positive regulation of stress fiber assemblySubstance-P receptorHomo sapiens (human)
response to electrical stimulusSubstance-P receptorHomo sapiens (human)
smooth muscle contraction involved in micturitionSubstance-P receptorHomo sapiens (human)
positive regulation of uterine smooth muscle contractionSubstance-P receptorHomo sapiens (human)
positive regulation of flagellated sperm motilitySubstance-P receptorHomo sapiens (human)
tachykinin receptor signaling pathwayNeuromedin-K receptorHomo sapiens (human)
positive regulation of heart rateNeuromedin-K receptorHomo sapiens (human)
response to estradiolNeuromedin-K receptorHomo sapiens (human)
regulation of dopamine metabolic processNeuromedin-K receptorHomo sapiens (human)
response to cocaineNeuromedin-K receptorHomo sapiens (human)
positive regulation of blood pressureNeuromedin-K receptorHomo sapiens (human)
regulation of feeding behaviorNeuromedin-K receptorHomo sapiens (human)
positive regulation of uterine smooth muscle contractionNeuromedin-K receptorHomo sapiens (human)
positive regulation of flagellated sperm motilityNeuromedin-K receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (4)

Processvia Protein(s)Taxonomy
tachykinin receptor activitySubstance-K receptorHomo sapiens (human)
protein bindingSubstance-K receptorHomo sapiens (human)
substance K receptor activitySubstance-K receptorHomo sapiens (human)
tachykinin receptor activitySubstance-P receptorHomo sapiens (human)
protein bindingSubstance-P receptorHomo sapiens (human)
substance P receptor activitySubstance-P receptorHomo sapiens (human)
protein bindingNeuromedin-K receptorHomo sapiens (human)
tachykinin receptor activityNeuromedin-K receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (9)

Processvia Protein(s)Taxonomy
plasma membraneSubstance-K receptorHomo sapiens (human)
sperm flagellumSubstance-K receptorHomo sapiens (human)
sperm headSubstance-K receptorHomo sapiens (human)
sperm midpieceSubstance-K receptorHomo sapiens (human)
sperm midpieceSubstance-K receptorHomo sapiens (human)
plasma membraneSubstance-K receptorHomo sapiens (human)
plasma membraneSubstance-P receptorHomo sapiens (human)
cell surfaceSubstance-P receptorHomo sapiens (human)
dendriteSubstance-P receptorHomo sapiens (human)
sperm flagellumSubstance-P receptorHomo sapiens (human)
cell bodySubstance-P receptorHomo sapiens (human)
sperm headSubstance-P receptorHomo sapiens (human)
sperm midpieceSubstance-P receptorHomo sapiens (human)
plasma membraneSubstance-P receptorHomo sapiens (human)
sperm midpieceSubstance-P receptorHomo sapiens (human)
plasma membraneNeuromedin-K receptorHomo sapiens (human)
dendrite membraneNeuromedin-K receptorHomo sapiens (human)
neuronal cell body membraneNeuromedin-K receptorHomo sapiens (human)
sperm midpieceNeuromedin-K receptorHomo sapiens (human)
plasma membraneNeuromedin-K receptorHomo sapiens (human)
sperm midpieceNeuromedin-K receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (34)

Assay IDTitleYearJournalArticle
AID211909In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.1992Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22
Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists.
AID83667Compound was evaluated for potency in SP-E system and relative potency was determined against Hamster urinary bladder1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
[pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype.
AID1203261Displacement of [125I][MePhe7]NKB from human NK3R expressed in CHO cell membranes after 90 mins by scintillation counting analysis2015Journal of medicinal chemistry, Apr-09, Volume: 58, Issue:7
Discovery and optimization of novel antagonists to the human neurokinin-3 receptor for the treatment of sex-hormone disorders (Part I).
AID187273Compound was evaluated for K+ release in SP-P system and relative potency was determined against rat partoid slices; ND means not determined1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
[pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype.
AID84684Compound was evaluated for effective dose against hamster bladder1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
[pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype.
AID187277Compound was evaluated for potency in SP-E system and relative potency was determined against rat duodenum1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
[pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype.
AID145627Compound was evaluated for concentration-dependent and oscillatory increase in [Ca2+], caused by activation of hNK3 receptors in CHO cells1998Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11
High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural template.
AID208100In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.1992Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22
Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists.
AID77495Compound was evaluated for potency relative to neurokinin B against SP-N system (enteric nerves of Guinea pig ileum)1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
[pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype.
AID211879The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 21999Journal of medicinal chemistry, Jul-29, Volume: 42, Issue:15
Importance of the aromatic residue at position 6 of [Nle(10)]neurokinin A(4-10) for binding to the NK-2 receptor and receptor activation.
AID75943Compound was evaluated for effective dose against guinea pig ileum1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
[pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype.
AID211880Inhibitory activity against human Tachykinin receptor 21999Journal of medicinal chemistry, Jul-29, Volume: 42, Issue:15
Importance of the aromatic residue at position 6 of [Nle(10)]neurokinin A(4-10) for binding to the NK-2 receptor and receptor activation.
AID208431Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P1996Journal of medicinal chemistry, Apr-12, Volume: 39, Issue:8
Use of a dipeptide chemical library in the development of non-peptide tachykinin NK3 receptor selective antagonists.
AID77493Compound was evaluated for K+ release in SP-P system and relative potency was determined against guinea pig ileum1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
[pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype.
AID1203183Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis2015Journal of medicinal chemistry, Apr-09, Volume: 58, Issue:7
Discovery and optimization of novel antagonists to the human neurokinin-3 receptor for the treatment of sex-hormone disorders (Part I).
AID1203182Displacement of [3H]-SB222200 from rat NK3R after 90 mins by scintillation counting analysis2015Journal of medicinal chemistry, Apr-09, Volume: 58, Issue:7
Discovery and optimization of novel antagonists to the human neurokinin-3 receptor for the treatment of sex-hormone disorders (Part I).
AID212383In vitro agonistic activity against tachykinin receptor 3 of everted rat protal vein.1992Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22
Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists.
AID1203181Displacement of [3H]-SB222200 from monkey NK3R after 90 mins by scintillation counting analysis2015Journal of medicinal chemistry, Apr-09, Volume: 58, Issue:7
Discovery and optimization of novel antagonists to the human neurokinin-3 receptor for the treatment of sex-hormone disorders (Part I).
AID175478Compound was evaluated for effective dose against rat duodenum1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
[pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype.
AID738397Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysis2013Bioorganic & medicinal chemistry, Apr-15, Volume: 21, Issue:8
Structure-activity relationship study of tachykinin peptides for the development of novel neurokinin-3 receptor selective agonists.
AID212235Inhibitory activity against cloned human Tachykinin receptor 3 in CHO cells labeled with [125I][MePhe7]-NKB1996Journal of medicinal chemistry, Apr-12, Volume: 39, Issue:8
Use of a dipeptide chemical library in the development of non-peptide tachykinin NK3 receptor selective antagonists.
AID211537Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA1996Journal of medicinal chemistry, Apr-12, Volume: 39, Issue:8
Use of a dipeptide chemical library in the development of non-peptide tachykinin NK3 receptor selective antagonists.
AID211530Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 21992Journal of medicinal chemistry, Oct-16, Volume: 35, Issue:21
A new class of high affinity ligands for the neurokinin A NK2 receptor: psi (CH2NR) reduced peptide bond analogues of neurokinin A4-10.
AID212079Inhibitory activity against Tachykinin receptor 3 in guinea pig cortical membranes labeled with [125 I][MePhe7]-NKB1996Journal of medicinal chemistry, Apr-12, Volume: 39, Issue:8
Use of a dipeptide chemical library in the development of non-peptide tachykinin NK3 receptor selective antagonists.
AID1203262Displacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysis2015Journal of medicinal chemistry, Apr-09, Volume: 58, Issue:7
Discovery and optimization of novel antagonists to the human neurokinin-3 receptor for the treatment of sex-hormone disorders (Part I).
AID145629Compound was evaluated for its ability to displace [3H]NKB binding in hNK3 receptors expressed in CHO cells1998Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11
High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural template.
AID1346386Human NK3 receptor (Tachykinin receptors)1990Regulatory peptides, Nov-15, Volume: 31, Issue:2
Antagonists for the neurokinin NK-3 receptor evaluated in selective receptor systems.
AID1346371Human NK2 receptor (Tachykinin receptors)1993Biochemical and biophysical research communications, Mar-31, Volume: 191, Issue:3
Characterization of the binding sites of [3H]SR 48968, a potent nonpeptide radioligand antagonist of the neurokinin-2 receptor.
AID1346386Human NK3 receptor (Tachykinin receptors)2001European journal of pharmacology, Feb-16, Volume: 413, Issue:2-3
Molecular and pharmacological characterization of the murine tachykinin NK(3) receptor.
AID1346371Human NK2 receptor (Tachykinin receptors)1997The Journal of pharmacology and experimental therapeutics, Jun, Volume: 281, Issue:3
Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist.
AID1346346Human NK1 receptor (Tachykinin receptors)1997The Journal of pharmacology and experimental therapeutics, Jun, Volume: 281, Issue:3
Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist.
AID1346386Human NK3 receptor (Tachykinin receptors)1992FEBS letters, Mar-24, Volume: 299, Issue:1
Molecular characterisation, expression and localisation of human neurokinin-3 receptor.
AID1346402Mouse NK3 receptor (Tachykinin receptors)2001European journal of pharmacology, Feb-16, Volume: 413, Issue:2-3
Molecular and pharmacological characterization of the murine tachykinin NK(3) receptor.
AID1346386Human NK3 receptor (Tachykinin receptors)1997The Journal of pharmacology and experimental therapeutics, Jun, Volume: 281, Issue:3
Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (1,094)

TimeframeStudies, This Drug (%)All Drugs %
pre-1990167 (15.27)18.7374
1990's343 (31.35)18.2507
2000's176 (16.09)29.6817
2010's302 (27.61)24.3611
2020's106 (9.69)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials13 (1.16%)5.53%
Reviews110 (9.78%)6.00%
Case Studies5 (0.44%)4.05%
Observational1 (0.09%)0.25%
Other996 (88.53%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
senktide[no description available]medium810
neurokinin a[no description available]medium3490
eledoisin[no description available]medium270peptide
substance p[no description available]medium4120peptideneurokinin-1 receptor agonist;
neurotransmitter;
vasodilator agent
substance p[no description available]medium4121peptideneurokinin-1 receptor agonist;
neurotransmitter;
vasodilator agent
neurokinin a(4-10)[no description available]medium50
substance p (6-11), glu(6)-[no description available]medium10
sr 48968[no description available]medium290
neurokinin a(4-10), tyr(5)-trp(6,8,9)-lys(10)-[no description available]medium50
r 396[no description available]medium20
gr 159897[no description available]medium10tryptamines
sr 142806[no description available]medium30
cp 99994[no description available]medium70
sb 223412[no description available]medium60
sb 222200[no description available]medium130quinolines
bufokinin[no description available]medium10
propranolol[no description available]medium40naphthalenes;
propanolamine;
secondary amine		anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic
dynorphins[no description available]medium1211
kiss1 protein, human[no description available]medium2265
neuromedin b[no description available]medium2522
histamine[no description available]medium60aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter
natriuretic peptide, brain[no description available]medium10polypeptide
neuropeptide y[no description available]medium130
leptin[no description available]medium150
gastrin-releasing peptide[no description available]medium991
gamma-aminobutyric acid[no description available]medium70amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
glutamic acid[no description available]medium130glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
catechin[no description available]medium11catechinantioxidant;
plant metabolite
epigallocatechin gallate[no description available]medium11flavans;
gallate ester;
polyphenol		antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite
colforsin[no description available]medium20acetate ester;
cyclic ketone;
labdane diterpenoid;
organic heterotricyclic compound;
tertiary alpha-hydroxy ketone;
triol		adenylate cyclase agonist;
anti-HIV agent;
antihypertensive agent;
plant metabolite;
platelet aggregation inhibitor;
protein kinase A agonist
histidine[no description available]medium50amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
dinoprost[no description available]medium20monocarboxylic acid;
prostaglandins Falpha		human metabolite;
mouse metabolite
thioflavin t[no description available]medium10organic chloride saltfluorochrome;
geroprotector;
histological dye
nickel[no description available]medium10metal allergen;
nickel group element atom		epitope;
micronutrient
acyline[no description available]medium30
letrozole[no description available]medium10nitrile;
triazoles		antineoplastic agent;
EC 1.14.14.14 (aromatase) inhibitor
sevoflurane[no description available]medium10ether;
organofluorine compound		central nervous system depressant;
inhalation anaesthetic;
platelet aggregation inhibitor
capsaicin[no description available]medium280capsaicinoidnon-narcotic analgesic;
TRPV1 agonist;
voltage-gated sodium channel blocker
capsazepine[no description available]medium10benzazepine;
catechols;
monochlorobenzenes;
thioureas		capsaicin receptor antagonist
enkephalin, leucine[no description available]medium140pentapeptide;
peptide zwitterion		analgesic;
delta-opioid receptor agonist;
human metabolite;
mu-opioid receptor agonist;
neurotransmitter;
rat metabolite
preproenkephalin[no description available]medium80
vasoactive intestinal peptide[no description available]medium60
cyclic gmp[no description available]medium303',5'-cyclic purine nucleotide;
guanyl ribonucleotide		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
trenbolone acetate[no description available]medium10steroid ester
altrenogest[no description available]medium103-hydroxy steroid
dihydrotestosterone[no description available]medium6017beta-hydroxy steroid;
17beta-hydroxyandrostan-3-one;
3-oxo-5alpha-steroid		androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
gliclazide[no description available]medium10
mefloquine[no description available]medium10
oxytocin[no description available]medium30heterodetic cyclic peptide;
peptide hormone		oxytocic;
vasodilator agent
oseltamivir[no description available]medium20acetamides;
amino acid ester;
cyclohexenecarboxylate ester;
primary amino compound		antiviral drug;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
environmental contaminant;
prodrug;
xenobiotic
bim 23127[no description available]medium50
methyltestosterone[no description available]medium1017beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
enone		anabolic agent;
androgen;
antineoplastic agent
naltrexone[no description available]medium60cyclopropanes;
morphinane-like compound;
organic heteropentacyclic compound		antidote to opioid poisoning;
central nervous system depressant;
environmental contaminant;
mu-opioid receptor antagonist;
xenobiotic
norbinaltorphimine[no description available]medium40isoquinolines
urea[no description available]medium20isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
benzoxazoles[no description available]medium101,3-benzoxazoles;
mancude organic heterobicyclic parent
sb 334867-a[no description available]medium10naphthyridine derivative
jnj 10397049[no description available]medium10
pituitrin[no description available]medium30
pd 168368[no description available]medium40
toluene 2,4-diisocyanate[no description available]medium30toluene meta-diisocyanateallergen;
hapten
estradiol 3-benzoate[no description available]medium2017beta-hydroxy steroid;
benzoate ester		estrogen receptor agonist;
xenoestrogen
u 0126[no description available]medium10aryl sulfide;
dinitrile;
enamine;
substituted aniline		antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
osteogenesis regulator;
vasoconstrictor agent
n-methylaspartate[no description available]medium90amino dicarboxylic acid;
D-alpha-amino acid;
D-aspartic acid derivative;
secondary amino compound		neurotransmitter agent
sr 142801[no description available]medium240
piperidines[no description available]medium490
gr 94800[no description available]medium20
u-50488[no description available]medium20dichlorobenzene;
monocarboxylic acid amide;
N-alkylpyrrolidine		analgesic;
antitussive;
calcium channel blocker;
diuretic;
kappa-opioid receptor agonist
u 69593[no description available]medium10monocarboxylic acid amide;
N-alkylpyrrolidine;
organic heterobicyclic compound;
oxaspiro compound		anti-inflammatory agent;
diuretic;
kappa-opioid receptor agonist
nicotine[no description available]medium403-(1-methylpyrrolidin-2-yl)pyridineanxiolytic drug;
biomarker;
immunomodulator;
mitogen;
neurotoxin;
nicotinic acetylcholine receptor agonist;
peripheral nervous system drug;
phytogenic insecticide;
plant metabolite;
psychotropic drug;
teratogenic agent;
xenobiotic
silver[no description available]medium30copper group element atom;
elemental silver		Escherichia coli metabolite
pyrroles[no description available]medium10pyrrole;
secondary amine
corticosterone[no description available]medium7011beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
astressin[no description available]medium20homodetic cyclic peptide;
polypeptide		corticotropin-releasing factor receptor antagonist;
neuroprotective agent
cp 154526[no description available]medium10
phosphorylcholine[no description available]medium40phosphocholinesallergen;
epitope;
hapten;
human metabolite;
mouse metabolite
pentazocine[no description available]medium11benzazocine
mezlocillin[no description available]medium190
gamma2-msh[no description available]medium20
sr140333b[no description available]medium10
inositol 1,4,5-trisphosphate[no description available]medium40myo-inositol trisphosphatemouse metabolite
neuromedin c[no description available]medium551
adrenomedullin[no description available]medium10
fluorescein[no description available]medium102-benzofurans;
gamma-lactone;
organic heteropentacyclic compound;
oxaspiro compound;
polyphenol;
xanthene dye		fluorescent dye;
radioopaque medium
neuromedin n[no description available]medium10
neurotensin[no description available]medium80peptide hormonehuman metabolite;
mitogen;
neurotransmitter;
vulnerary
6-cyano-7-nitroquinoxaline-2,3-dione[no description available]medium10quinoxaline derivative
glucagon-like peptide 1[no description available]medium10
glucagon[no description available]medium40peptide hormone
sirolimus[no description available]medium10antibiotic antifungal drug;
cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
organic heterotricyclic compound;
secondary alcohol		antibacterial drug;
anticoronaviral agent;
antineoplastic agent;
bacterial metabolite;
geroprotector;
immunosuppressive agent;
mTOR inhibitor
acetic acid[no description available]medium10monocarboxylic acidantimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent
fluorescein-5-isothiocyanate[no description available]medium10fluorescein isothiocyanate
neurotensin (8-13)[no description available]medium10
septide[no description available]medium100
pyrrolidonecarboxylic acid[no description available]medium2505-oxoproline;
L-proline derivative;
non-proteinogenic L-alpha-amino acid		algal metabolite
tetrodotoxin[no description available]medium240azatetracycloalkane;
oxatetracycloalkane;
quinazoline alkaloid		animal metabolite;
bacterial metabolite;
marine metabolite;
neurotoxin;
voltage-gated sodium channel blocker
atropine[no description available]medium220
hexamethonium[no description available]medium30quaternary ammonium salt
neurokinin a (3-10), lysyl(3)-glycyl(8)-r-lactam-leucine(9)-[no description available]medium70
neurokinin a (4-10), beta-ala(8)-[no description available]medium90
mastoparan[no description available]medium10mastoparans;
peptidyl amide		antimicrobial agent
2-amino-5-phosphonovalerate[no description available]medium10non-proteinogenic alpha-amino acidNMDA receptor antagonist
valine[no description available]medium40L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid;
valine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline[no description available]medium10naphthalenes;
sulfonic acid derivative
quinoxalines[no description available]medium10mancude organic heterobicyclic parent;
naphthyridine;
ortho-fused heteroarene
arginine vasopressin[no description available]medium70vasopressincardiovascular drug;
hematologic agent;
mitogen
endothelin-1[no description available]medium10
phyllolitorin[no description available]medium20
carbamazepine[no description available]medium10dibenzoazepine;
ureas		analgesic;
anticonvulsant;
antimanic drug;
drug allergen;
EC 3.5.1.98 (histone deacetylase) inhibitor;
environmental contaminant;
glutamate transporter activator;
mitogen;
non-narcotic analgesic;
sodium channel blocker;
xenobiotic
leucine[no description available]medium30amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
haloperidol[no description available]medium50aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol		antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist
gefitinib[no description available]medium10aromatic ether;
monochlorobenzenes;
monofluorobenzenes;
morpholines;
quinazolines;
secondary amino compound;
tertiary amino compound		antineoplastic agent;
epidermal growth factor receptor antagonist
acetylcysteine[no description available]medium10acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
phosphotyrosine[no description available]medium20L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid;
O(4)-phosphotyrosine		Escherichia coli metabolite;
immunogen
quinazolines[no description available]medium10azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinazolines
angiotensin ii[no description available]medium70amino acid zwitterion;
angiotensin II		human metabolite
rc 3095[no description available]medium20
gold[no description available]medium10copper group element atom;
elemental gold
11-cis-retinal[no description available]medium10retinalchromophore;
human metabolite;
mouse metabolite
formaldehyde[no description available]medium30aldehyde;
one-carbon compound		allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
galanin-like peptide[no description available]medium10
adamantane[no description available]medium10adamantanes;
polycyclic alkane
alpha-neoendorphin[no description available]medium10
ovalbumin[no description available]medium20
lysophosphatidic acid[no description available]medium101-acyl-sn-glycerol 3-phosphate
bradykinin[no description available]medium90oligopeptidehuman blood serum metabolite;
vasodilator agent
lactic acid[no description available]medium102-hydroxy monocarboxylic acidalgal metabolite;
Daphnia magna metabolite
hydrochloric acid[no description available]medium20chlorine molecular entity;
gas molecular entity;
hydrogen halide;
mononuclear parent hydride		mouse metabolite
pirinixic acid[no description available]medium10aryl sulfide;
organochlorine compound;
pyrimidines
thyroxine[no description available]medium702-halophenol;
iodophenol;
L-phenylalanine derivative;
non-proteinogenic L-alpha-amino acid;
thyroxine zwitterion;
thyroxine		antithyroid drug;
human metabolite;
mouse metabolite;
thyroid hormone
triiodothyronine[no description available]medium502-halophenol;
amino acid zwitterion;
iodophenol;
iodothyronine		human metabolite;
mouse metabolite;
thyroid hormone
ciprofibrate[no description available]medium10cyclopropanes;
monocarboxylic acid;
organochlorine compound		antilipemic drug
cholecystokinin[no description available]medium90
preprotachykinin b (50-79)[no description available]medium60
ng-nitroarginine methyl ester[no description available]medium50alpha-amino acid ester;
L-arginine derivative;
methyl ester;
N-nitro compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor
indomethacin[no description available]medium70aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
phosphoramidon[no description available]medium100deoxyaldohexose phosphate;
dipeptide		bacterial metabolite;
EC 3.4.24.11 (neprilysin) inhibitor;
EC 3.4.24.71 (endothelin-converting enzyme 1) inhibitor
sr 140333[no description available]medium110
quinuclidines[no description available]medium120quinuclidines;
saturated organic heterobicyclic parent
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid[no description available]medium20non-proteinogenic alpha-amino acid
colchicine[no description available]medium30alkaloid;
colchicine		anti-inflammatory agent;
gout suppressant;
mutagen
physalaemin[no description available]medium120
substance p, sar(9)-met(o2)(11)-[no description available]medium130
bromochloroacetic acid[no description available]medium102-bromocarboxylic acid;
monocarboxylic acid;
organochlorine compound
carboxypeptidase b[no description available]medium10
15-hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic acid[no description available]medium10
sumatriptan[no description available]medium10sulfonamide;
tryptamines		serotonergic agonist;
vasoconstrictor agent
butorphanol[no description available]medium10morphinane alkaloidantitussive;
kappa-opioid receptor agonist;
mu-opioid receptor agonist;
opioid analgesic
deuterium[no description available]medium10dihydrogen
dodecylphosphocholine[no description available]medium10phosphocholinesdetergent
methacholine chloride[no description available]medium40quaternary ammonium salt
technetium tc 99m sestamibi[no description available]medium10
iturelix[no description available]medium10
galantide[no description available]medium10
quinacrine[no description available]medium10acridines;
aromatic ether;
organochlorine compound;
tertiary amino compound		antimalarial;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor
arachidonic acid[no description available]medium70icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid		Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite
u 73122[no description available]medium20aromatic ether;
aza-steroid;
maleimides		EC 3.1.4.11 (phosphoinositide phospholipase C) inhibitor
1,6-bis(cyclohexyloximinocarbonyl)hexane[no description available]medium10carbamate ester;
organonitrogen compound
tiletamine hydrochloride[no description available]medium10
u 73343[no description available]medium10
carbachol[no description available]medium110ammonium salt;
carbamate ester		cardiotonic drug;
miotic;
muscarinic agonist;
nicotinic acetylcholine receptor agonist;
non-narcotic analgesic
stilbamidine[no description available]medium10
glycine[no description available]medium30alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
thromboxane a2[no description available]medium20epoxy monocarboxylic acid;
thromboxanes A		mouse metabolite
1-methyl-3-isobutylxanthine[no description available]medium103-isobutyl-1-methylxanthine
dimyristoylphosphatidylcholine[no description available]medium201,2-diacyl-sn-glycero-3-phosphocholine;
phosphatidylcholine 28:0;
tetradecanoate ester		antigen;
mouse metabolite
aspartic acid[no description available]medium10aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
kallidin[no description available]medium10peptide
citric acid, anhydrous[no description available]medium10tricarboxylic acidantimicrobial agent;
chelator;
food acidity regulator;
fundamental metabolite
fk 888[no description available]medium10peptide
substance p, arg(1)-pro(2)-trp(7),(9)-leunh(2)(11)-[no description available]medium30
substance p, prolyl(2)-tryptophan(7,9)-[no description available]medium70
substance p, methyl ester-[no description available]medium90
phenylalanine[no description available]medium40amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid		algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
cp 96345[no description available]medium150
choline[no description available]medium10cholinesallergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite
5-methoxytryptamine[no description available]medium10aromatic ether;
primary amino compound;
tryptamines		5-hydroxytryptamine 2A receptor agonist;
5-hydroxytryptamine 2B receptor agonist;
5-hydroxytryptamine 2C receptor agonist;
antioxidant;
cardioprotective agent;
human metabolite;
mouse metabolite;
neuroprotective agent;
radiation protective agent;
serotonergic agonist
2-methyl-5-ht[no description available]medium10tryptaminesserotonergic agonist
7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one[no description available]medium90
amphetamine[no description available]medium10primary amine
cocaine[no description available]medium10benzoate ester;
methyl ester;
tertiary amino compound;
tropane alkaloid		adrenergic uptake inhibitor;
central nervous system stimulant;
dopamine uptake inhibitor;
environmental contaminant;
local anaesthetic;
mouse metabolite;
plant metabolite;
serotonin uptake inhibitor;
sodium channel blocker;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic
caffeine[no description available]medium10purine alkaloid;
trimethylxanthine		adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic
thiorphan[no description available]medium70N-acyl-amino acid
fk 224[no description available]medium30
fura-2[no description available]medium10
guanylyl imidodiphosphate[no description available]medium50nucleoside triphosphate analogue
nitroarginine[no description available]medium10guanidines;
L-arginine derivative;
N-nitro compound;
non-proteinogenic L-alpha-amino acid
arginine[no description available]medium50arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
guanethidine[no description available]medium30azocanes;
guanidines		adrenergic antagonist;
antihypertensive agent;
sympatholytic agent
isoproterenol[no description available]medium20catechols;
secondary alcohol;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
sympathomimetic agent
cyclo(gln-trp-phe-gly-leu-met)[no description available]medium20
gr 73632[no description available]medium50
morphine[no description available]medium20morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic
substance p[no description available]medium30pentapeptide
sch 32615[no description available]medium10
neurokinin a (4-10), nle(10)-[no description available]medium50
rubidium[no description available]medium10alkali metal atom
methanol[no description available]medium10alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
kuwanon h[no description available]medium10resorcinols;
tetrahydroxyflavone		plant metabolite
kuwanon g[no description available]medium10resorcinols;
tetrahydroxyflavone		anti-inflammatory agent;
plant metabolite
litorin[no description available]medium30
ranatensin[no description available]medium70
kainic acid[no description available]medium40dicarboxylic acid;
L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid		antinematodal drug;
excitatory amino acid agonist
dactinomycin[no description available]medium10actinomycinmutagen
tachykinin neuropeptide gamma[no description available]medium30
cromolyn sodium[no description available]medium10organic sodium saltanti-asthmatic drug;
drug allergen
n-succinimidyl-3-(4-hydroxyphenyl)propionate[no description available]medium40
dinoprostone[no description available]medium50prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
evans blue[no description available]medium40organic sodium saltfluorochrome;
histological dye;
sodium channel blocker;
teratogenic agent
6-ketoprostaglandin f1 alpha[no description available]medium30prostaglandins Falphahuman metabolite;
mouse metabolite
codeine[no description available]medium10morphinane alkaloid;
organic heteropentacyclic compound		antitussive;
drug allergen;
environmental contaminant;
opioid analgesic;
opioid receptor agonist;
prodrug;
xenobiotic
gr 71251[no description available]medium10
leukotriene d4[no description available]medium10dipeptide;
leukotriene;
organic sulfide		bronchoconstrictor agent;
human metabolite;
mouse metabolite
1-hexadecyl-2-acetyl-glycero-3-phosphocholine[no description available]medium202-acetyl-1-alkyl-sn-glycero-3-phosphocholineantihypertensive agent;
beta-adrenergic antagonist;
bronchoconstrictor agent;
hematologic agent;
vasodilator agent
3,4-dihydroxyphenylacetic acid[no description available]medium10catechols;
dihydroxyphenylacetic acid		human metabolite
aldosterone[no description available]medium2011beta-hydroxy steroid;
18-oxo steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid hormone;
mineralocorticoid;
primary alpha-hydroxy ketone;
steroid aldehyde		human metabolite;
mouse metabolite
bombesin, leu(13)-psi-ch2nh-leu(14)-[no description available]medium30
bombesin (6-13), phe(6) methyl ester-[no description available]medium20
bombesin, tyr(4)-[no description available]medium20
alanine[no description available]medium30alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
monensin[no description available]medium10cyclic hemiketal;
monocarboxylic acid;
polyether antibiotic;
spiroketal		antifungal agent;
coccidiostat;
ionophore
cycloheximide[no description available]medium10antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol		anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
adenosine 5'-o-(3-thiotriphosphate)[no description available]medium10nucleoside triphosphate analogue
guanosine 5'-o-(3-thiotriphosphate)[no description available]medium30nucleoside triphosphate analogue
inositol[no description available]medium10cyclitol;
hexol
cyclic imp[no description available]medium103',5'-cyclic purine nucleotide;
nucleoside 3',5'-cyclic phosphate		mammalian metabolite;
Saccharomyces cerevisiae metabolite
dizocilpine maleate[no description available]medium10maleate salt;
tetracyclic antidepressant		anaesthetic;
anticonvulsant;
neuroprotective agent;
nicotinic antagonist;
NMDA receptor antagonist
p-methoxy-n-methylphenethylamine[no description available]medium20aromatic ether;
secondary amino compound		metabolite
amiloride[no description available]medium30aromatic amine;
guanidines;
organochlorine compound;
pyrazines		diuretic;
sodium channel blocker
gastrins[no description available]medium90
big gastrin[no description available]medium10
thapsigargin[no description available]medium40butyrate ester;
organic heterotricyclic compound;
sesquiterpene lactone		calcium channel blocker;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor
penicillamine[no description available]medium10non-proteinogenic alpha-amino acid;
penicillamine		antirheumatic drug;
chelator;
copper chelator;
drug allergen
s-nitroso-n-acetylpenicillamine[no description available]medium10nitroso compound;
nitrosothio compound		nitric oxide donor;
vasodilator agent
epidermal growth factor[no description available]medium10
tyrosyl-isoleucyl-glycyl-seryl-arginine[no description available]medium10
lysine[no description available]medium20aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
biocytin[no description available]medium20azabicycloalkane;
L-alpha-amino acid zwitterion;
L-lysine derivative;
monocarboxylic acid amide;
non-proteinogenic L-alpha-amino acid;
thiabicycloalkane;
ureas		mouse metabolite
1-amino-1,3-dicarboxycyclopentane[no description available]medium20
cycloleucine[no description available]medium20non-proteinogenic alpha-amino acidEC 2.5.1.6 (methionine adenosyltransferase) inhibitor
2-amino-3-phosphonopropionic acid[no description available]medium10alanine derivative;
non-proteinogenic alpha-amino acid;
phosphonic acids		human metabolite;
metabotropic glutamate receptor antagonist
nitrogen dioxide[no description available]medium10nitrogen oxide
hydroxyindoleacetic acid[no description available]medium10indole-3-acetic acidsdrug metabolite;
human metabolite;
mouse metabolite
methimazole[no description available]medium101,3-dihydroimidazole-2-thionesantithyroid drug
memantine[no description available]medium10adamantanes;
primary aliphatic amine		antidepressant;
antiparkinson drug;
dopaminergic agent;
neuroprotective agent;
NMDA receptor antagonist
phenoxybenzamine[no description available]medium20aromatic amine
cytochalasin d[no description available]medium20
guanosine triphosphate[no description available]medium10guanosine 5'-phosphate;
purine ribonucleoside 5'-triphosphate		Escherichia coli metabolite;
mouse metabolite;
uncoupling protein inhibitor
tyrosine[no description available]medium40amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
substance p (6-11)[no description available]medium20
substance p, pro(9)-[no description available]medium10
losartan[no description available]medium10biphenylyltetrazole;
imidazoles		angiotensin receptor antagonist;
anti-arrhythmia drug;
antihypertensive agent;
endothelin receptor antagonist
naloxone[no description available]medium90morphinane alkaloid;
organic heteropentacyclic compound;
tertiary alcohol		antidote to opioid poisoning;
central nervous system depressant;
mu-opioid receptor antagonist
sq-23377[no description available]medium10cyclic ether;
enol;
polyunsaturated fatty acid;
very long-chain fatty acid		calcium ionophore;
metabolite
sincalide[no description available]medium40oligopeptide
bucladesine[no description available]medium103',5'-cyclic purine nucleotide
sb 218795[no description available]medium10quinolines
dithiothreitol[no description available]medium101,4-dimercaptobutane-2,3-diol;
butanediols;
dithiol;
glycol;
thiol		chelator;
human metabolite;
reducing agent
cysteine[no description available]medium10cysteiniumfundamental metabolite
ethylmaleimide[no description available]medium20maleimidesanticoronaviral agent;
EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.1.1 (hexokinase) inhibitor
tetradecanoylphorbol acetate[no description available]medium30acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
calcimycin[no description available]medium20benzoxazole
bisindolylmaleimide i[no description available]medium20
tyrphostin 25[no description available]medium10benzenetriol
lysophosphatidylcholines[no description available]medium101-O-acyl-sn-glycero-3-phosphocholine
delta sleep-inducing peptide[no description available]medium10
baclofen[no description available]medium10amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid;
monochlorobenzenes;
primary amino compound		central nervous system depressant;
GABA agonist;
muscle relaxant
bicuculline[no description available]medium10benzylisoquinoline alkaloid;
isoquinoline alkaloid;
isoquinolines		agrochemical;
central nervous system stimulant;
GABA-gated chloride channel antagonist;
GABAA receptor antagonist;
neurotoxin
cgp 55845a[no description available]medium10
2-(4-amylcinnamoyl)amino-4-chlorobenzoic acid[no description available]medium10
15-hydroxy-5,8,11,13-eicosatetraenoic acid[no description available]medium10
dodecyl sulfate[no description available]medium10alkyl sulfate
sodium dodecyl sulfate[no description available]medium20organic sodium saltdetergent;
protein denaturant
substance p, pro(2)-phe(7)-trp(9)-[no description available]medium10
n-formylmethionine leucyl-phenylalanine[no description available]medium30tripeptide
norleucine[no description available]medium102-aminohexanoic acid;
L-alpha-amino acid zwitterion;
non-proteinogenic L-alpha-amino acid
pd 176252[no description available]medium20
sodium chromate(vi)[no description available]medium10inorganic sodium saltcarcinogenic agent;
diagnostic agent;
oxidising agent;
poison
chromates[no description available]medium10chromium oxoanion;
divalent inorganic anion		oxidising agent
transforming growth factor beta[no description available]medium10
lithium chloride[no description available]medium10inorganic chloride;
lithium salt		antimanic drug;
geroprotector
trifluoroethanol[no description available]medium10fluoroalcohol
tryptophan[no description available]medium10erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
methionine[no description available]medium10aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid		antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical
urechistachykinin ii[no description available]medium10
urechistachykinin i[no description available]medium10
bombesin(6-14), hca(6)-leu(13)-psi(ch2n)-tac(14)-[no description available]medium10
citrulline[no description available]medium10amino acid zwitterion;
citrulline		Daphnia magna metabolite;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
protective agent;
Saccharomyces cerevisiae metabolite
captopril[no description available]medium40alkanethiol;
L-proline derivative;
N-acylpyrrolidine;
pyrrolidinemonocarboxylic acid		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
isoleucine[no description available]medium10aspartate family amino acid;
isoleucine;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
serine[no description available]medium10L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid;
serine zwitterion;
serine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
angiotensin iii[no description available]medium10
fenclonine[no description available]medium10phenylalanine derivative
ssr 146977[no description available]medium10
thromboxane b2[no description available]medium10thromboxanes Bhuman metabolite;
mouse metabolite
pentylenetetrazole[no description available]medium10organic heterobicyclic compound;
organonitrogen heterocyclic compound
chlorine[no description available]medium50halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
pempidine[no description available]medium10piperidines
l 703606[no description available]medium10
w 7[no description available]medium20
trifluoperazine[no description available]medium10N-alkylpiperazine;
N-methylpiperazine;
organofluorine compound;
phenothiazines		antiemetic;
calmodulin antagonist;
dopaminergic antagonist;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor;
EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor;
phenothiazine antipsychotic drug
calmidazolium[no description available]medium10imidazolium ionapoptosis inducer;
calmodulin antagonist
interleukin-8[no description available]medium10
ranakinin[no description available]medium10
ubenimex[no description available]medium20
phentolamine[no description available]medium30imidazoles;
phenols;
substituted aniline;
tertiary amino compound		alpha-adrenergic antagonist;
vasodilator agent
substance p (5-11)[no description available]medium10
sulpiride[no description available]medium10benzamides;
N-alkylpyrrolidine;
sulfonamide		antidepressant;
antiemetic;
antipsychotic agent;
dopaminergic antagonist
substance p (5-11), asp(5,6)-mephe(8)-[no description available]medium30
methanesulfonyl fluoride[no description available]medium10
alpha,beta-methyleneadenosine 5'-triphosphate[no description available]medium10nucleoside triphosphate analogue
pentolinium tartrate[no description available]medium10tartrate saltantihypertensive agent
dihydro-beta-erythroidine[no description available]medium10delta-lactone;
organic heterotetracyclic compound;
tertiary amino compound		nicotinic antagonist
veratridine[no description available]medium10
edrophonium[no description available]medium10phenols;
quaternary ammonium ion		antidote;
diagnostic agent;
EC 3.1.1.8 (cholinesterase) inhibitor
physostigmine[no description available]medium10carbamate ester;
indole alkaloid		antidote to curare poisoning;
EC 3.1.1.8 (cholinesterase) inhibitor;
miotic
5,7-dihydroxytryptamine[no description available]medium10
3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate[no description available]medium101,1-diunsubstituted alkanesulfonate
barium[no description available]medium10alkaline earth metal atom;
elemental barium
tetraethylammonium[no description available]medium10quaternary ammonium ion
glucose, (beta-d)-isomer[no description available]medium10D-glucopyranoseepitope;
mouse metabolite
egtazic acid[no description available]medium10diether;
tertiary amino compound;
tetracarboxylic acid		chelator
gastrin releasing peptide (14-27)[no description available]medium10
enkephalin, methionine[no description available]medium10
enkephalinamide-met, ala(2)-[no description available]medium10
substance p (6-11), arg(6)-trp(7,9)-me-phe(8)-[no description available]medium10
peptide phi[no description available]medium10
substance p, arg(1)-pro(2)-trp(7,9)-leu(11)-[no description available]medium20
pilocarpine[no description available]medium10pilocarpineantiglaucoma drug
yohimbine[no description available]medium10methyl 17-hydroxy-20xi-yohimban-16-carboxylatealpha-adrenergic antagonist;
dopamine receptor D2 antagonist;
serotonergic antagonist
methysergide[no description available]medium20ergoline alkaloid
diphenhydramine[no description available]medium20ether;
tertiary amino compound		anti-allergic agent;
antidyskinesia agent;
antiemetic;
antiparkinson drug;
antipruritic drug;
antitussive;
H1-receptor antagonist;
local anaesthetic;
muscarinic antagonist;
oneirogen;
sedative
alaproclate[no description available]medium10alpha-amino acid ester
imipramine[no description available]medium10dibenzoazepineadrenergic uptake inhibitor;
antidepressant;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
zimeldine[no description available]medium10styrenes
potassium chloride[no description available]medium10inorganic chloride;
inorganic potassium salt;
potassium salt		fertilizer
tiopronin[no description available]medium10N-acyl-amino acid
mecamylamine[no description available]medium10primary aliphatic amine
idazoxan[no description available]medium10benzodioxine;
imidazolines		alpha-adrenergic antagonist
tryptamine[no description available]medium10aminoalkylindole;
aralkylamino compound;
indole alkaloid;
tryptamines		human metabolite;
mouse metabolite;
plant metabolite
d-ala(2),mephe(4),met(0)-ol-enkephalin[no description available]medium10
substance p, tyr(8)-[no description available]medium10
cimetidine[no description available]medium10aliphatic sulfide;
guanidines;
imidazoles;
nitrile		adjuvant;
analgesic;
anti-ulcer drug;
H2-receptor antagonist;
P450 inhibitor
substance p (4-11), beta-ala(4)-sar(9)-met(02)(11)-[no description available]medium10
pyrilamine[no description available]medium10aromatic ether;
ethylenediamine derivative		H1-receptor antagonist
oxidopamine[no description available]medium10benzenetriol;
catecholamine;
primary amino compound		drug metabolite;
human metabolite;
neurotoxin
bumetanide[no description available]medium10amino acid;
benzoic acids;
sulfonamide		diuretic;
EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor
devazepide[no description available]medium101,4-benzodiazepinone;
indolecarboxamide		antineoplastic agent;
apoptosis inducer;
cholecystokinin antagonist;
gastrointestinal drug
ceruletide[no description available]medium10oligopeptidediagnostic agent;
gastrointestinal drug
enalaprilat anhydrous[no description available]medium10dicarboxylic acid;
dipeptide		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
enalapril[no description available]medium10dicarboxylic acid monoester;
dipeptide		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
geroprotector;
prodrug
manganese[no description available]medium10elemental manganese;
manganese group element atom		Escherichia coli metabolite;
micronutrient
eicosapentaenoic acid[no description available]medium10icosapentaenoic acid;
omega-3 fatty acid		anticholesteremic drug;
antidepressant;
antineoplastic agent;
Daphnia galeata metabolite;
fungal metabolite;
micronutrient;
mouse metabolite;
nutraceutical
pentobarbital[no description available]medium10barbituratesGABAA receptor agonist
bethanechol[no description available]medium10carbamate ester;
quaternary ammonium ion		muscarinic agonist
threonine[no description available]medium10amino acid zwitterion;
aspartate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
threonine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
oxyntomodulin[no description available]medium10
1-palmitoyl-2-oleoylphosphatidylcholine[no description available]medium10
phosphatidylcholines[no description available]medium101,2-diacyl-sn-glycero-3-phosphocholine
fomesafen[no description available]medium50aromatic ether;
C-nitro compound;
monochlorobenzenes;
N-sulfonylcarboxamide;
organofluorine compound;
phenols		agrochemical;
EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide
phenylephrine hydrochloride[no description available]medium20hydrochloride
bassianolide[no description available]medium10cyclodepsipeptide;
cyclooctadepsipeptide		antineoplastic agent;
fungal metabolite;
insecticide
guaifenesin[no description available]medium60methoxybenzenes
2-propanol[no description available]medium70secondary alcohol;
secondary fatty alcohol		protic solvent
trolamine salicylate[no description available]medium10
eye[no description available]medium20
terlipressin[no description available]low00polypeptide
(4R)-4-[[(2S)-2-[[[2-(1-amino-2-methylbutyl)-4,5-dihydrothiazol-4-yl]-oxomethyl]amino]-4-methyl-1-oxopentyl]amino]-5-[[(2S,3S)-1-[[(3S,6R,9S,12R,15S,18R,21S)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-15-[(2S)-butan-2-yl]-6-(carboxymethyl)-9-(1H-imidazol-5[no description available]low00polypeptide
baci-im[no description available]low00homodetic cyclic peptide;
polypeptide;
zwitterion		antibacterial agent;
antimicrobial agent
bivalirudin[no description available]low00polypeptideanticoagulant;
EC 3.4.21.5 (thrombin) inhibitor
atrial natriuretic factor[no description available]low00polypeptide
thymalfasin[no description available]low00polypeptide
ganirelix[no description available]low00polypeptide
abarelix[no description available]low00polypeptideantineoplastic agent;
hormone antagonist
nociceptin[no description available]low00organic molecular entity;
polypeptide		human metabolite;
rat metabolite
teriparatide[no description available]low00polypeptide
forapin[no description available]low00peptidyl amide;
polypeptide		animal metabolite;
antineoplastic agent;
apoptosis inducer;
EC 2.7.11.13 (protein kinase C) inhibitor;
hepatoprotective agent;
neuroprotective agent;
venom
salmon calcitonin[no description available]low00heterodetic cyclic peptide;
peptide hormone;
polypeptide		bone density conservation agent;
metabolite
liraglutide[no description available]low00lipopeptide;
polypeptide		glucagon-like peptide-1 receptor agonist;
neuroprotective agent
acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ilys-prolyl-alaninamide[no description available]low00polypeptide
alx-0600[no description available]low00polypeptideantioxidant;
glucagon-like peptide-2 receptor agonist;
metabolite;
protective agent
msh, 4-nle-7-phe-alpha-[no description available]low00polypeptidedermatologic drug
melanotan-1[no description available]low00polypeptidedermatologic drug
gonadorelin hydrochloride[no description available]low00polypeptide
arthrofactin[no description available]low00polypeptide
p-Glu-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe[no description available]low00polypeptideapoptosis inhibitor;
human metabolite;
neuroprotective agent
semaglutide[no description available]low00lipopeptide;
polypeptide		anti-obesity agent;
appetite depressant;
glucagon-like peptide-1 receptor agonist;
hypoglycemic agent;
neuroprotective agent
cigb-300[no description available]low00heterodetic cyclic peptide;
polypeptide		angiogenesis modulating agent;
antineoplastic agent;
apoptosis inducer;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
calpastatin[no description available]low00polypeptideEC 3.4.22.52 (calpain-1) inhibitor;
EC 3.4.22.53 (calpain-2) inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Abnormalities, Teeth0low10
Abnormalities, Tooth0low10
Abortion, Spontaneous0low10
Abortion, Tubal0low10
Absence Seizure0low30
Absence Seizures0low30
Ache0low150
Acinar Carcinoma0low10
Acinar Cell Adenocarcinoma0low10
Acinic Cell Adenocarcinoma0low10
Acinic Cell Carcinoma0low10
Acinic Cell Tumor0low10
Acquired Meningomyelocele0low10
Acute Confusional Senile Dementia0low40
Acute Disease0low10
Acute Onset Vascular Dementia0low10
Adenocarcinoma0low10
Adenocarcinoma, Basal Cell0low10
Adenocarcinoma, Granular Cell0low10
Adenocarcinoma, Oxyphilic0low10
Adenocarcinoma, Tubular0low10
Adenoma, Malignant0low10
Adenoma, Prolactin-Secreting, Pituitary0low10
Adenoma, Prostatic0low10
Adolescent Obesity0low10
Adolescent Overweight0low10
Adrenal Gland Hypofunction0low20
Adrenal Insufficiency0low20
Affective Psychosis, Bipolar0low10
Aging0low180
Airway Obstruction0low10
Akinetic-Rigid Variant of Huntington Disease0low10
Alcohol Drinking0low20
Allergic Contact Dermatitis0low10
Allergic Reaction0low10
Allergy0low10
Allergy, Food0low10
Allodynia0low50
Allodynia, Mechanical0low50
Allodynia, Tactile0low50
Allodynia, Thermal0low50
Alloxan Diabetes0low70
Alveolitis, Fibrosing0low10
Alzheimer Dementia0low40
Alzheimer Disease0low40
Alzheimer Disease, Early Onset0low40
Alzheimer Disease, Late Onset0low40
Alzheimer Sclerosis0low40
Alzheimer Syndrome0low40
Alzheimer Type Senile Dementia0low40
Alzheimer-Type Dementia (ATD)0low40
Alzheimer's Disease0low40
Alzheimer's Disease, Focal Onset0low40
Alzheimer's Diseases0low40
Ambiguous Genitalia0medium21
Amenorrhea0low40
Anaplastic Astrocytoma0low30
Anasarca0low50
Anesthesia0low20
Angina Pectoris0low10
Angiostrongylus Infections0low10
Angor Pectoris0low10
Anorexia0low10
Anosmic Hypogonadism0low20
Anosmic Idiopathic Hypogonadotropic Hypogonadism0low20
Anoxemia0low30
Anoxia0low30
Anxiety0low40
Appetite Disorders0low10
Argentaffinoma0low30
Arteriosclerosis0low10
Arteriosclerosis, Coronary0low10
Arteriosclerotic Dementia0low10
Arteriosclerotic Encephalopathy, Subcortical0low10
Arthritis0low10
Arthritis, Rheumatoid0low30
Asthma0low30
Asthma, Bronchial0low30
Astrocytoma0low30
Astrocytoma, Grade I0low30
Astrocytoma, Grade II0low30
Astrocytoma, Grade III0low30
Astrocytoma, Grade IV0low50
Astrocytoma, Protoplasmic0low30
Astrocytoma, Subependymal Giant Cell0low30
Astroglioma0low30
Asymmetric Diabetic Proximal Motor Neuropathy0low10
Atherosclerosis, Coronary0low10
Atonic Absence Seizure0low30
Atonic Absence Seizures0low30
Atonic Seizure0low30
Atonic Seizures0low30
Aura0low10
Autoimmune Disease0low10
Autoimmune Diseases0low10
Autosomal Chromosome Disorders0low10
Autosomal Dominant Form of Kallmann Syndrome0low20
Autosomal Recessive Form of Kallmann Syndrome0low20
Awakening Epilepsy0low10
Back Ache0low10
Back Pain0low10
Back Pain with Radiation0low10
Back Pain without Radiation0low10
Backache0low10
Bacterial Disease0low10
Bacterial Infection0low10
Bacterial Infections0low10
Bardet-Biedl Syndrome0low10
Benign Neoplasms0low10
Benign Neoplasms, Brain0low40
Benign Prostatic Hyperplasia0low10
Benign Psychomotor Epilepsy, Childhood0low10
Binswanger Disease0low10
Binswanger Encephalopathy0low10
Binswanger's Disease0low10
Bipolar Disorder0low10
Bipolar Mood Disorder0low10
Bladder Disorder, Neurogenic0low10
Bladder Neurogenesis0low10
Bladder Pain Syndrome0low10
Bladder, Neurogenic0low10
Bladder, Overactive0low20
Blastocyst Disintegration0low10
Blood Pressure, High0medium51
Body Weight0low110
Bone Loss, Osteoclastic0low10
Bone Resorption0low10
Bowel Diseases, Inflammatory0low10
Brain Cancer0low40
Brain Ischemia0low10
Brain Metastases0low40
Brain Neoplasm, Primary0low40
Brain Neoplasms0low40
Brain Neoplasms, Benign0low40
Brain Neoplasms, Malignant0low40
Brain Neoplasms, Malignant, Primary0low40
Brain Neoplasms, Primary Malignant0low40
Brain Tumor, Primary0low40
Brain Tumor, Recurrent0low40
Brain Tumors0low40
Breast Cancer0low20
Breast Carcinoma0low20
Breast Neoplasms0low20
Breast Tumors0low20
Bronchial Asthma0low30
Bronchial Hyperreactivity0low20
Cancer0low10
Cancer of Brain0low40
Cancer of Breast0low20
Cancer of Colon0low20
Cancer of Intestines0low10
Cancer of Lung0low100
Cancer of Pancreas0low10
Cancer of Pituitary0low30
Cancer of Prostate0low10
Cancer of Rectum0low10
Cancer of the Brain0low40
Cancer of the Breast0low20
Cancer of the Colon0low20
Cancer of the Intestines0low10
Cancer of the Lung0low100
Cancer of the Pancreas0low10
Cancer of the Pituitary0low30
Cancer of the Prostate0low10
Cancer of the Rectum0low10
Carcinoid0low30
Carcinoid Tumor0low30
Carcinoid, Goblet Cell0low30
Carcinoma0low20
Carcinoma, Acinar Cell0low10
Carcinoma, Anaplastic0low20
Carcinoma, Cribriform0low10
Carcinoma, Granular Cell0low10
Carcinoma, Non-Small Cell Lung0low30
Carcinoma, Non-Small-Cell Lung0low30
Carcinoma, Oat Cell0low40
Carcinoma, Small Cell0low40
Carcinoma, Spindle-Cell0low20
Carcinoma, Tubular0low10
Carcinoma, Undifferentiated0low20
Carcinomatosis0low20
Cardiovascular Stroke0low10
Cat Diseases0low10
Central Hypothyroidism0low50
Central Nervous System Disease0low10
Central Nervous System Diseases0low10
Central Nervous System Disorder0low10
Central Nervous System Disorders0low10
Centrala nervsystemets sjukdomar@sv0low10
Cerebral Astrocytoma0low30
Cerebral Infarction, Middle Cerebral Artery0low10
Cerebral Ischemia0low10
Child Obesity0low10
Childhood Benign Psychomotor Epilepsy0low10
Childhood Cerebral Astrocytoma0low30
Childhood Obesity0low10
Childhood Onset Obesity0low10
Childhood Overweight0low10
Choking0low10
Cholera Infantum0low20
Chondrosarcoma0low10
Chorea, Chronic Progressive Hereditary (Huntington)0low10
Choroby OUN@pl0low10
Chromosomal Disorders0low10
Chromosome Abnormality Disorders0low10
Chromosome Disorders0low10
Chronic Disease0low20
Chronic Illness0low20
Chronic Interstitial Cystitis0low10
Chronic Kidney Diseases0low10
Chronic Kidney Insufficiency0low10
Chronic Progressive Hereditary Chorea (Huntington)0low10
Chronic Progressive Subcortical Encephalopathy0low10
Chronic Renal Diseases0low10
Chronic Renal Insufficiency0low10
Chronically Ill0low20
Chylopericardium0low10
Clonic Seizure0low30
Clonic Seizures0low30
CNS Disease0low10
CNS Diseases0low10
Cochlear Hearing Loss0low10
Cognition Disorders0low10
Colitis Gravis0low10
Colitis, Granulomatous0low10
Colitis, Ulcerative0low10
Colon Cancer0low20
Colon Neoplasms0low20
Colonic Cancer0low20
Colonic Neoplasms0low20
Complex Partial Seizure0low30
Complex Partial Seizures0low30
Complications, Pregnancy0low20
Constricted Pupil0low10
Contact Dermatitis0low10
Convulsion0low30
Convulsion, Non-Epileptic0low30
Convulsions0low30
Convulsive Seizure0low30
Convulsive Seizures0low30
Coronary Arteriosclerosis0low10
Coronary Artery Disease0low10
Coronary Atherosclerosis0low10
Cough0low30
Crohn Disease0low10
Crohn's Disease0low10
Crohn's Enteritis0low10
Cystitis, Chronic Interstitial0low10
Cystitis, Interstitial0low10
Deafness Neurosensory0low10
Decerebrate Posturing0low20
Decerebrate State0low20
Decorticate Rigidity0low20
Decorticate State0low20
Deficiency, Oxygen0low30
Degenerative Diseases, Central Nervous System0low10
Degenerative Diseases, Nervous System0low10
Degenerative Diseases, Neurologic0low10
Degenerative Diseases, Spinal Cord0low10
Degenerative Neurologic Diseases0low10
Degenerative Neurologic Disorders0low10
Delayed Effects, Prenatal Exposure0low50
Delayed Puberty0low30
Dementia Praecox0low10
Dementia, Alzheimer Type0low40
Dementia, Presenile0low40
Dementia, Primary Senile Degenerative0low40
Dementia, Senile0low40
Dementia, Vascular0low10
Depression, Bipolar0low10
Depression, Involutional0low10
Depressive Disorder, Major0low10
Dermatitis Herpetiformis0low10
Dermatitis Venenata0low10
Dermatitis, Allergic Contact0low10
Dermatitis, Allergic Eczematous0low10
Dermatitis, Atopic0low10
Dermatitis, Contact0low10
Dermatitis, Contact, Allergic0low10
Diabetes Mellitus0low10
Diabetes Mellitus, Adult-Onset0low20
Diabetes Mellitus, Experimental0low70
Diabetes Mellitus, Gestational0low10
Diabetes Mellitus, Ketosis-Resistant0low20
Diabetes Mellitus, Maturity-Onset0low20
Diabetes Mellitus, Non Insulin Dependent0low20
Diabetes Mellitus, Non-Insulin-Dependent0low20
Diabetes Mellitus, Noninsulin Dependent0low20
Diabetes Mellitus, Noninsulin-Dependent0low20
Diabetes Mellitus, Slow-Onset0low20
Diabetes Mellitus, Stable0low20
Diabetes Mellitus, Type 20low20
Diabetes Mellitus, Type II0low20
Diabetes, Gestational0low10
Diabetes, Pregnancy-Induced0low10
Diabetic Amyotrophy0low10
Diabetic Asymmetric Polyneuropathy0low10
Diabetic Autonomic Neuropathy0low10
Diabetic Mononeuropathy0low10
Diabetic Mononeuropathy Simplex0low10
Diabetic Neuralgia0low10
Diabetic Neuropathies0low10
Diabetic Neuropathy, Painful0low10
Diabetic Polyneuropathy0low10
Disease0low10
Disease Models, Animal0low180
Disease, Pulmonary0low10
Diseases of Endocrine System0low10
Diseases, Metabolic0low10
Diseases, Pulmonary0low10
Disintegration of Blastocyst0low10
Disintegration of Embryo0low10
Disorders of Sex Development0medium21
Disorders of Sexual Development0medium21
Doenu00E7as do Sistema Nervoso Central@pt0low10
Dropsy0low50
Drug Withdrawal Symptoms0low10
Duhring Disease0low10
Duhring's Disease0low10
Dysplasia Olfactogenitalis of De Morsier0low20
Early Onset Alzheimer Disease0low40
Early Pregnancy Loss0low10
Eating and Feeding Disorders0low10
Eating Disorders0low10
Eclampsia0low10
Eczema, Atopic0low10
Eczema, Contact0low10
Eczema, Infantile0low10
Edema0low50
Edema-Proteinuria-Hypertension Gestosis0medium251
Edema, Pulmonary0low10
Edemas, Pulmonary0low10
EHS Tumor0low10
Electrolytes0low10
Embolic Infarction, Middle Cerebral Artery0low10
Embolus, Middle Cerebral Artery0low10
Embryo Death0low10
Embryo Disintegration0low10
Embryo Loss0low10
Embryo Resorption0low10
Embryopathies0low10
Emesis0low10
Encephalopathy, Binswanger0low10
Encephalopathy, Binswanger's0low10
Encephalopathy, Chronic Progressive Subcortical0low10
Encephalopathy, Ischemic0low10
Encephalopathy, Subcortical Arteriosclerotic0low10
Encephalopathy, Subcortical, Chronic Progressive0low10
Endocrine Diseases0low10
Endocrine System Diseases0low10
Enfermedades del Sistema Nervioso Central@es0low10
Enteritis, Granulomatous0low10
Enteritis, Regional0low10
EPH Complex0medium251
EPH Gestosis0medium251
EPH Toxemias0medium251
Epilepsy0low10
Epilepsy, Benign Psychomotor, Childhood0low10
Epilepsy, Cryptogenic0low10
Epilepsy, Lateral Temporal0low10
Epilepsy, Temporal Lobe0low10
Epilepsy, Uncinate0low10
Epileptic Seizure0low30
Epileptic Seizures0low30
Epileptiform Neuralgia0low10
Epiphora0low10
Epithelial Neoplasms, Malignant0low20
Epithelial Tumors, Malignant0low20
Epithelioma0low20
Equine Diseases0low10
Erectile Dysfunction0low10
Experimental Diabetes Mellitus0low70
Experimental Lung Inflammation0low10
Experimental Sarcoma0low10
Experimental Sarcomas0low10
Extravasation of Contrast Media0low10
Extravasation of Diagnostic and Therapeutic Materials0low10
Extravasation of Diagnostic, Therapeutic Materials0low10
Eye Injuries0low10
Familial Alzheimer Disease (FAD)0low40
Familial Precocious Puberty0medium121
Feeding and Eating Disorders0low10
Feeding Disorders0low10
Feline Diseases0low10
Fetal Diseases0low10
Fetal Growth Restriction0medium31
Fetal Growth Retardation0medium31
Fibrillary Astrocytoma0low30
Fibroid0low10
Fibroid Tumor0low10
Fibroid Uterus0low10
Fibroids, Uterine0low10
Fibroma, Uterine0low10
Fibromyoma0low10
Fibroses, Pulmonary0low10
Fibrosis, Pulmonary0low10
Flushing0low10
Focal Onset Alzheimer's Disease0low40
Food Allergy0low10
Food Hypersensitivity0low10
Fothergill Disease0low10
Froehlich's Syndrome0low10
Functional Gastrointestinal Disorders0low20
Gastric Diseases0low10
Gastric Fistula0low10
Gastrointestinal Diseases0low20
Gastrointestinal Disorders0low20
Gastrointestinal Disorders, Functional0low20
Gemistocytic Astrocytoma0low30
Generalized Absence Seizure0low30
Generalized Absence Seizures0low30
Generalized Tonic-Clonic Seizures0low30
Genetic Predisposition0low50
Genetic Predisposition to Disease0low50
Genetic Susceptibility0low50
Genital Ambiguity0medium21
Gestational Diabetes0low10
Gestational Hypertension0low10
Gestosis, EPH0medium251
Giant Cell Glioblastoma0low50
Glaucoma0low10
Glial Cell Tumors0low50
Glioblastoma0low50
Glioblastoma Multiforme0low50
Glioma0low50
Glioma, Astrocytic0low30
Grippe0low10
Growth Disorders0low30
Growth Retardation, Intrauterine0medium31
Hay Fever0low10
Hayfever0low10
Hearing Loss, Cochlear0low10
Hearing Loss, Sensorineural0low10
Heart Attack0low10
HELLP Syndrome0low10
Hemolysis, Elevated Liver Enzymes, Lowered Platelets0low10
Hemopericardium0low10
Hemorrhage, Subarachnoid0low10
Hermaphroditism0medium21
Horse Diseases0low10
Hot Flashes0medium102
Human Flu0low10
Human Influenza0low10
Human Mammary Carcinoma0low20
Huntington Chorea0low10
Huntington Chronic Progressive Hereditary Chorea0low10
Huntington Disease0low10
Huntington Disease, Akinetic-Rigid Variant0low10
Huntington Disease, Juvenile0low10
Huntington Disease, Juvenile-Onset0low10
Huntington Disease, Late Onset0low10
Huntington's Chorea0low10
Huntington's Disease0low10
Hydrops0low50
Hyperalgesia0low50
Hyperalgesia, Mechanical0low50
Hyperalgesia, Primary0low50
Hyperalgesia, Secondary0low50
Hyperalgesia, Tactile0low50
Hyperalgesia, Thermal0low50
Hyperalgesic Sensations0low50
Hyperalgia0low50
Hyperalgia, Mechanical0low50
Hyperalgia, Primary0low50
Hyperalgia, Secondary0low50
Hyperandrogenism0low20
Hyperesthesia0low10
Hyperesthesia, Tactile0low10
Hyperesthesia, Thermal0low10
Hyperesthetic Sensations0low10
Hyperglycemia0low10
Hyperglycemia, Postprandial0low10
Hypergonadotropic Hypogonadism0low200
Hypernutrition0low10
Hypersensitivity0low10
Hypersensitivity, Contact0low10
Hypersensitivity, Food0low10
Hypertension0medium51
Hypertension-Edema-Proteinuria Gestosis0medium251
Hypertension, Pregnancy-Induced0low10
Hyperthyroid0low40
Hyperthyroidism0low40
Hypertrophy0low20
Hypertrophy, Left Ventricular0low10
Hypoadrenalism0low20
Hypogonadism0low200
Hypogonadism, Isolated Hypogonadotropic0low200
Hypogonadotropic Hypogonadism0low200
Hypogonadotropic Hypogonadism and Anosmia0low20
Hypogonadotropic Hypogonadism-Anosmia Syndrome0low20
Hypogonadotropic Hypogonadism, Anosmia, and Midline Cranial Anomalies (Cleft Lip, Cleft Palate and Imperfect Fusion)0low20
Hypothalamic Diseases0low10
Hypothalamic Dysfunction Syndromes0low10
Hypothalamic Dysinhibition Syndrome0low10
Hypothalamic Overactivity Syndrome0low10
Hypothalamic Pseudopuberty0low10
Hypothalamic-Adenohypophyseal Disorders0low10
Hypothalamic-Neurohypophyseal Disorders0low10
Hypothermia0low10
Hypothermia, Accidental0low10
Hypothyroidism0low50
Hypoxemia0low30
Hypoxia0low30
Idiopathic Diffuse Interstitial Pulmonary Fibrosis0low10
Idiopathic Parkinson Disease0low10
Idiopathic Parkinson's Disease0low10
Idiopathic Proctocolitis0low10
Idiopathic Sexual Precocity0medium121
Ileitis, Regional0low10
Ileitis, Terminal0low10
Ileocolitis0low10
Impotence0low10
Infant Obesity0low10
Infant Overweight0low10
Infantile Obesity0low10
Infarction, Middle Cerebral Artery0low10
Infection0low10
Infection and Infestation0low10
Infection, Bacterial0low10
Infections0low10
Infections and Infestations0low10
Infections, Bacterial0low10
Infections, Orthomyxoviridae0low10
Infections, Orthomyxovirus0low10
Infections, Stephanurus dentatus0low10
Infections, Strongylida0low10
Infertility0low10
Infertility, Female0medium31
Infertility, Male0low10
Inflammation0low90
Inflammatory Bowel Disease 10low10
Inflammatory Bowel Disease, Ulcerative Colitis Type0low10
Inflammatory Bowel Diseases0low10
Influenza0low10
Influenza in Humans0low10
Influenza, Human0low10
Injuries, Eye0low10
Innate Inflammatory Response0low90
Intersex Conditions0medium21
Intersexuality0medium21
Interstitial Cystitis0low10
Interstitial Cystitis, Chronic0low10
Intestinal Cancer0low10
Intestinal Neoplasms0low10
Intestines Cancer0low10
Intestines Neoplasms0low10
Intracranial Astrocytoma0low30
Intracranial Neoplasms0low40
Intrauterine Growth Restriction0medium31
Intrauterine Growth Retardation0medium31
Ischemia, Cerebral0low10
Ischemic Encephalopathy0low10
Itching0low90
Jacksonian Seizure0low30
Juvenile Huntington Disease0low10
Juvenile Pilocytic Astrocytoma0low30
Juvenile-Onset Huntington Disease0low10
Kallmann Syndrome0low20
Kallmann Syndrome 10low20
Kallmann Syndrome 20low20
Kallmann Syndrome 30low20
Kallmann Syndrome, Type 1, X-linked0low20
Kallmann Syndrome, Type 3, Recessive0low20
Kallmann's Syndrome0low20
Keskushermoston sairaudet@fi0low10
Kidney Insufficiency, Chronic0low10
Labhart-Willi Syndrome0low10
Labhart-Willi-Prader-Fanconi Syndrome0low10
Labor, Premature0low30
Lacrimal Apparatus Diseases0low10
Lactotroph Adenoma0low10
Late Effects, Prenatal Exposure0low50
Late Onset Alzheimer Disease0low40
Late-Onset Huntington Disease0low10
Laurence-Moon-Bardet-Biedl Syndrome0low10
Leanness0low10
Left Main Coronary Artery Disease0low10
Left Main Coronary Disease0low10
Left Main Disease0low10
Left Middle Cerebral Artery Infarction0low10
Left Ventricular Hypertrophy0low10
Leiomyoma0low10
Leiomyoma, Uterine0low10
Leukoencephalopathy, Subcortical0low10
Lewy Body Parkinson Disease0low10
Lewy Body Parkinson's Disease0low10
Lobar Pneumonia0low10
Lung Cancer0low100
Lung Diseases0low10
Lung Inflammation0low10
Lung Neoplasms0low100
Macroprolactinoma0low10
Major Depressive Disorder0low10
Maladie du systu00E8me nerveux central@fr0low10
Malattie del sistema nervoso centrale@it0low10
Male Impotence0low10
Male Sexual Impotence0low10
Malignancy0low10
Malignant Epithelial Neoplasms0low20
Malignant Glioma0low50
Malignant Neoplasm of Breast0low20
Malignant Neoplasms0low10
Malignant Neoplasms, Brain0low40
Malignant Primary Brain Neoplasms0low40
Malignant Primary Brain Tumors0low40
Malignant Tumor of Breast0low20
Malnourishment0low30
Malnutrition0low30
Mammary Cancer0low20
Mammary Carcinoma, Human0low20
Mammary Neoplasm, Human0low20
Mammary Neoplasms, Human0low20
Manic Depression0low10
Manic Disorder0low10
Manic-Depressive Psychosis0low10
Maturity-Onset Diabetes0low20
Maturity-Onset Diabetes Mellitus0low20
MCA Infarct0low10
MCA Infarction0low10
Mechanical Allodynia0low50
Mechanical Hyperalgesia0low50
Melancholia, Involutional0low10
Meningomyelocele0low10
Menopause0medium101
Metabolic Diseases0low10
Microprolactinoma0low10
Middle Cerebral Artery Circulation Infarction0low10
Middle Cerebral Artery Embolic Infarction0low10
Middle Cerebral Artery Embolus0low10
Middle Cerebral Artery Infarction0low10
Middle Cerebral Artery Occlusion0low10
Middle Cerebral Artery Stroke0low10
Middle Cerebral Artery Syndrome0low10
Middle Cerebral Artery Thrombosis0low10
Middle Cerebral Artery Thrombotic Infarction0low10
Miosis0low10
Miosis, Persistent0low10
Miscarriage0low10
Mixed Glioma0low50
MODY0low20
Mononeuropathy, Diabetic0low10
Muscle Contraction0low850
Muscle Relaxation0low60
Myelocele0low10
Myelomeningocele0low10
Myelomeningocele, Acquired0low10
Myocardial Infarct0low10
Myocardial Infarction0low10
Myoclonic Seizure0low30
Myoclonic Seizures0low30
nemoci centru00E1lnu00EDho nervovu00E9ho systu00E9mu@cs0low10
Neoplasia0low10
Neoplasm0low10
Neoplasms0low10
Neoplasms, Benign0low10
Neoplasms, Brain0low40
Neoplasms, Brain, Benign0low40
Neoplasms, Brain, Malignant0low40
Neoplasms, Brain, Primary0low40
Neoplasms, Breast0low20
Neoplasms, Colonic0low20
Neoplasms, Intestinal0low10
Neoplasms, Intracranial0low40
Neoplasms, Lung0low100
Neoplasms, Malignant Epithelial0low20
Neoplasms, Pancreatic0low10
Neoplasms, Prostate0low10
Neoplasms, Prostatic0low10
Neoplasms, Pulmonary0low100
Neoplasms, Rectal0low10
Neoplasms, Trophoblastic0low10
Nerve Degeneration0low10
Nerve Pain0low10
Nervous System Degenerative Diseases0low10
Neuralgia0low10
Neuralgia, Atypical0low10
Neuralgia, Diabetic0low10
Neuralgia, Iliohypogastric Nerve0low10
Neuralgia, Ilioinguinal0low10
Neuralgia, Perineal0low10
Neuralgia, Stump0low10
Neuralgia, Supraorbital0low10
Neuralgia, Vidian0low10
Neuritis0low10
Neuritis, Motor0low10
Neuritis, Peripheral0low10
Neuritis, Sensory0low10
Neuroblastoma0low30
Neurodegenerative Diseases0low10
Neurodegenerative Disorders0low10
Neurodermatitis, Atopic0low10
Neurodermatitis, Disseminated0low10
Neurodynia0low10
Neurogenic Bladder0low10
Neurogenic Bladder Disorder0low10
Neurogenic Bladder, Atonic0low10
Neurogenic Bladder, Spastic0low10
Neurogenic Bladder, Uninhibited0low10
Neurogenic Dysfunction of the Urinary Bladder0low10
Neurogenic Inflammation0low10
Neurogenic Urinary Bladder Disorder0low10
Neurogenic Urinary Bladder, Atonic0low10
Neurogenic Urinary Bladder, Spastic0low10
Neurogenic Urinary Bladder, Uninhibited0low10
Neurologic Degenerative Conditions0low10
Neurologic Degenerative Diseases0low10
Neurologic Diseases, Degenerative0low10
Neuron Degeneration0low10
Neuropathic Bladder0low10
Neuropathic Pain0low10
NIDDM0low20
Non-Epileptic Seizure0low30
Non-Epileptic Seizures0low30
Non-Small Cell Lung Cancer0low30
Non-Small Cell Lung Carcinoma0low30
Non-Small-Cell Lung Carcinoma0low30
Nonepileptic Seizure0low30
Nonepileptic Seizures0low30
Noninsulin-Dependent Diabetes Mellitus0low20
Nonsmall Cell Lung Cancer0low30
Nutritional Deficiency0low30
Oat Cell Carcinoma0low40
Obesity0medium181
Obesity in Adolescence0low10
Obesity in Childhood0low10
Obstetric Labor, Premature0low30
Occlusion, Middle Cerebral Artery0low10
Odontome0low10
Oligoastrocytoma, Mixed0low30
Orthomyxoviridae Infections0low10
Orthomyxovirus Infections0low10
Osteoclastic Bone Loss0low10
Overactive Bladder0low20
Overactive Detrusor0low20
Overactive Detrusor Function0low20
Overactive Urinary Bladder0low20
Overinclusion0low10
Overnutrition0low10
Overweight0low20
Oxyesthesia0low10
Oxygen Deficiency0low30
Pain0low150
Pain, Burning0low150
Pain, Crushing0low150
Pain, Migratory0low150
Pain, Radiating0low150
Pain, Splitting0low150
Painful Bladder Syndrome0low10
Pancreas Cancer0low10
Pancreas Neoplasms0low10
Pancreatic Cancer0low10
Pancreatic Neoplasms0low10
Paralysis Agitans0low10
Paraphrenia, Involutional0low10
Parkinson Disease0low10
Parkinson Disease, Idiopathic0low10
Parkinson's Disease0low10
Parkinson's Disease, Idiopathic0low10
Parkinson's Disease, Lewy Body0low10
Paroxysmal Nerve Pain0low10
Partial Seizure0low30
Partial Seizures0low30
Pediatric Obesity0low10
Pemphigoid0low10
Pemphigoid, Bullous0low10
Pericardial Effusion0low10
Perinatal Subarachnoid Hemorrhage0low10
Petit Mal Convulsion0low30
Pilocytic Astrocytoma0low30
Pituitary Adenoma0low30
Pituitary Adenoma, Prolactin-Secreting0low10
Pituitary Cancer0low30
Pituitary Carcinoma0low30
Pituitary Diencephalic Syndrome0low10
Pituitary Neoplasms0low30
Pituitary Tumors0low30
Pneumonia0low10
Pneumonia, Lobar0low10
Pneumonitis0low10
Pollen Allergy0low10
Pollinosis0low10
Polyarthritis0low10
Polycystic Ovarian Syndrome0medium151
Polycystic Ovary Syndrome0medium151
Polycystic Ovary Syndrome 10medium151
Polyneuritis0low10
Postpartum Amenorrhea0low40
Postprandial Hyperglycemia0low10
Prader Labhart Willi Syndrome0low10
Prader-Labhart-Willi Syndrome0low10
Prader-Willi Syndrome0low10
Pre-Eclampsia0medium251
Precocious Puberty0medium121
Precocious Puberty, Central0medium121
Precocious Puberty, Male Limited0medium121
Precocious Puberty, Male-Limited0medium121
Predisposition, Genetic0low50
Preeclampsia0medium251
Preeclampsia Eclampsia 10medium251
Pregnancy0medium541
Pregnancy Complications0low20
Pregnancy Induced Hypertension0low10
Pregnancy Toxemias0medium251
Premature Labor0low30
Premature Obstetric Labor0low30
Prenatal Exposure Delayed Effects0low50
Presenile Alzheimer Dementia0low40
Preterm Labor0low30
Primary Brain Neoplasms0low40
Primary Hyperthyroidism0low40
Primary Hypothyroidism0low50
Primary Malignant Brain Neoplasms0low40
Primary Malignant Brain Tumors0low40
Primary Parkinsonism0low10
Primary Senile Degenerative Dementia0low40
PRL-Secreting Pituitary Adenoma0low10
Progressive Chorea, Chronic Hereditary (Huntington)0low10
Progressive Chorea, Hereditary, Chronic (Huntington)0low10
Prolactin-Producing Pituitary Adenoma0low10
Prolactin-Secreting Pituitary Adenoma0low10
Prolactinoma0low10
Prolactinoma, Familial0low10
Prostate Cancer0low10
Prostate Neoplasms0low10
Prostatic Adenoma0low10
Prostatic Cancer0low10
Prostatic Hyperplasia0low10
Prostatic Hyperplasia, Benign0low10
Prostatic Hypertrophy0low10
Prostatic Hypertrophy, Benign0low10
Prostatic Neoplasms0low10
Proteinuria0low10
Proteinuria-Edema-Hypertension Gestosis0medium251
Pruritis0low90
Pruritus0low90
Pseudohermaphroditism0medium21
Psychoses, Manic-Depressive0low10
Psychosis, Involutional0low10
Psychosis, Manic-Depressive0low10
Pubertas Praecox0medium121
Puberty, Delayed0low30
Puberty, Precocious0medium121
Pulmonary Cancer0low100
Pulmonary Disease0low10
Pulmonary Diseases0low10
Pulmonary Edema0low10
Pulmonary Edemas0low10
Pulmonary Fibroses0low10
Pulmonary Fibrosis0low10
Pulmonary Inflammation0low10
Pulmonary Neoplasms0low100
Pupillary Miosis0low10
Recrudescence0low10
Rectal Cancer0low10
Rectal Neoplasms0low10
Rectal Tumors0low10
Rectum Cancer0low10
Rectum Neoplasms0low10
Recurrence0low10
Regional Enteritis0low10
Relapse0low10
Renal Insufficiency, Chronic0low10
Reproductive Sterility0low10
Rheumatoid Arthritis0low30
Rhinitis, Allergic, Nonseasonal0low30
Rhinitis, Allergic, Perennial0low30
Rhinitis, Allergic, Seasonal0low10
Right Middle Cerebral Artery Infarction0low10
Rigidity, Decerebrate0low20
Rigidity, Decorticate0low20
Royer Syndrome0low10
Royer's Syndrome0low10
SAH (Subarachnoid Hemorrhage)0low10
Sarcoma, Engelbreth-Holm-Swarm0low10
Sarcoma, Experimental0low10
Sarcoma, Jensen0low10
Sarcomas, Experimental0low10
Schizophrenia0low10
Schizophrenic Disorders0low10
Sclerocystic Ovarian Degeneration0medium151
Sclerocystic Ovaries0medium151
Sclerocystic Ovary Syndrome0medium151
Seasonal Allergic Rhinitis0low10
Secondary Hypothyroidism0low50
Secondary Trigeminal Neuralgia0low10
Seizure0low30
Seizure Disorder0low10
Seizures0low30
Seizures, Auditory0low30
Seizures, Clonic0low30
Seizures, Convulsive0low30
Seizures, Epileptic0low30
Seizures, Focal0low30
Seizures, Generalized0low30
Seizures, Gustatory0low30
Seizures, Motor0low30
Seizures, Olfactory0low30
Seizures, Sensory0low30
Seizures, Somatosensory0low30
Seizures, Tonic0low30
Seizures, Tonic-Clonic0low30
Seizures, Vertiginous0low30
Seizures, Vestibular0low30
Seizures, Visual0low30
Senile Dementia, Acute Confusional0low40
Senile Dementia, Alzheimer Type0low40
Sensation Disorders0low10
Sensitivity and Specificity0low20
Sensitivity, Contact0low10
Sensorineural Hearing Loss0low10
Sensory Disorders0low10
Serous Acinar Adenoma0low10
Sex Development Disorders0medium21
Sex Differentiation Disorders0medium21
Sexual Development Disorders0medium21
Sexual Differentiation Disorders0medium21
Sexual Precocity0medium121
Single Seizure0low30
Small Cell Carcinoma0low40
Small Pupil0low10
Sneezing0low10
Soft Tissue Neoplasms0low10
Special Senses Disorders0low10
Spontaneous Abortion0low10
SREDIu0160NJI u017DIVu010CANI SUSTAV, BOLESTI@hr0low10
Stein-Leventhal Syndrome0medium151
Stenocardia0low10
Stephanurus dentatus Infections0low10
Sterility0low10
Sterility, Female0medium31
Sterility, Male0low10
Sterility, Postpartum0medium31
Sterility, Reproductive0low10
Stomach Diseases0low10
Stomach Fistula0low10
Streptozocin Diabetes0low70
Streptozotocin Diabetes0low70
Stroke, Middle Cerebral Artery0low10
Strongylida Infections0low10
Stunted Growth0low30
Stunting0low30
Sub-Fertility0low10
Sub-Fertility, Female0medium31
Sub-Fertility, Male0low10
Subarachnoid Hemorrhage0low10
Subarachnoid Hemorrhage, Aneurysmal0low10
Subarachnoid Hemorrhage, Intracranial0low10
Subarachnoid Hemorrhage, Spontaneous0low10
Subcortical Arteriosclerotic Encephalopathy0low10
Subcortical Encephalopathy, Chronic Progressive0low10
Subcortical Leukoencephalopathy0low10
Subcortical Vascular Dementia0low10
Subependymal Giant Cell Astrocytoma0low30
Subfertility0low10
Subfertility, Female0medium31
Subfertility, Male0low10
Substance Withdrawal Syndrome0low10
Suffering, Physical0low150
Susceptibility, Genetic0low50
Swine Influenza0low10
Sykdommer i sentralnervesystemet@no0low10
Symmetric Diabetic Proximal Motor Neuropathy0low10
Symptom Cluster0low10
Syndrome0low10
Syngamiasis0low10
Tachyarrhythmia0low10
Tachycardia0low10
Tactile Allodynia0low50
Teeth Abnormalities0low10
Testotoxicosis0medium121
Thermal Allodynia0low50
Thesaurismosis0low10
Thinness0low10
Thrombosis, Middle Cerebral Artery0low10
Thrombotic Infarction, Middle Cerebral Artery0low10
Thyroid-Stimulating Hormone Deficiency0low50
Tic Doloureux0low10
Tic Douloureux0low10
Tonic Clonic Seizure0low30
Tonic Seizure0low30
Tonic Seizures0low30
Tonic-Clonic Seizure0low30
Tonic-Clonic Seizures0low30
Tooth Abnormalities0low10
Toxemia Of Pregnancy0medium251
Toxemias, Pregnancy0medium251
Tracheitis0low10
Transient Hypertension, Pregnancy0low10
Trifacial Neuralgia0low10
Trigeminal Neuralgia0low10
Trigeminal Neuralgia, Idiopathic0low10
Trigeminal Neuralgia, Secondary0low10
Trophoblast Cancer0low10
Trophoblast Neoplasms0low10
Trophoblast Tumor0low10
Trophoblastic Cancer0low10
Trophoblastic Neoplasms0low10
Trophoblastic Tumor0low10
TSH Deficiency0low50
Tumors0low10
Tumors, Breast0low20
Type 2 Diabetes0low20
Type 2 Diabetes Mellitus0low20
u041Du0415u0420u0412u041Du041Eu0419 u0421u0418u0421u0422u0415u041Cu042B u0426u0415u041Du0422u0420u0410u041Bu042Cu041Du041Eu0419 u0411u041Eu041Bu0415u0417u041Du0418@ru0low10
u4E2Du67A2u795Eu7D4Cu7CFBu75BEu60A3@ja0low10
Ulcerative Colitis0low10
Undernutrition0low30
Underweight0low10
Urethral Obstruction0low10
Urinary Bladder Disorder, Neurogenic0low10
Urinary Bladder Neurogenesis0low10
Urinary Bladder Neurogenic Dysfunction0low10
Urinary Bladder, Neurogenic0low10
Urinary Bladder, Overactive0low20
Urinary Tract Diseases0low10
Urologic Diseases0low10
Urological Diseases0low10
Vascular Calcification0low10
Vascular Calcinosis0low10
Vascular Dementia0low10
Vascular Dementia, Acute Onset0low10
Ventricular Hypertrophy, Left0low10
Vertebrogenic Pain Syndrome0low10
Viral Diseases0low10
Viral Infections0low10
Virus Diseases0low10
Virus Infections0low10
Vomiting0low10
Weight Loss0low10
Weight Reduction0low10
Wet Lung0low10
Willi-Prader Syndrome0low10
Withdrawal Symptoms0low10
Zentralnervensystemkrankheiten@de0low10
Ziekte, centraalzenuwstelsel-@nl0low10
Zollinger-Ellison Syndrome0low10

Research Highlights

Safety/Toxicity (5)

ArticleYear
Testicular toxicity induced by a triple neurokinin receptor antagonist in male dogs.
Reproductive toxicology (Elmsford, N.Y.), Volume: 31, Issue: 4		2011
Secretoneurin and the tachykinins substance P and neurokinin-A/B in NMDA-induced excitotoxicity in the rat retina.
Regulatory peptides, Nov-30, Volume: 165, Issue: 1		2010
Membrane associated functions of neurokinin B (NKB) on Abeta (25-35) induced toxicity in aging rat brain synaptosomes.
Biogerontology, Volume: 7, Issue: 1		2006
Neuroprotective role of neurokinin B (NKB) on beta-amyloid (25-35) induced toxicity in aging rat brain synaptosomes: involvement in oxidative stress and excitotoxicity.
Biogerontology, Volume: 7, Issue: 1		2006
A tachykinin-like factor increases glutamate toxicity in rat cerebellar granule cells.
Neuropharmacology, Volume: 44, Issue: 1		2003
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Long-term Use (2)

ArticleYear
Neuroprotection of acetylcholinergic basal forebrain neurons by memantine and neurokinin B.
Behavioural brain research, Volume: 83, Issue: 1-2		1997
CCK-antagonist L-364,718: influence on rat pancreatic growth induced by caerulein and bombesin-like peptides.
Regulatory peptides, Volume: 24, Issue: 1		1989
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pharmacokinetics (3)

ArticleYear
[Effects of obesity on peak level of luteinizing hormone in gonadotropin-releasing hormone agonist test and obesity-related hormones in girls with central precocious puberty].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, Volume: 17, Issue: 8		2015
Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist.
The Journal of pharmacology and experimental therapeutics, Volume: 281, Issue: 3		1997
NK1 receptors mediate tachykinin-induced increase in microvascular clearance in hamster cheek pouch.
The American journal of physiology, Volume: 265, Issue: 2 Pt 2		1993
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (2)

ArticleYear
Synthesis and evaluation of piperazinotriazoles. Discovery of a potent and orally bioavailable neurokinin-3 receptor inhibitor.
European journal of medicinal chemistry, Sep-05, Volume: 257		2023
Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist.
The Journal of pharmacology and experimental therapeutics, Volume: 281, Issue: 3		1997
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (14)

ArticleYear
Effects of neuropeptides on the sumatriptan-disturbed circulation in the optic nerve head of rabbits.
Pharmacology, Volume: 70, Issue: 3		2004
Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist.
The Journal of pharmacology and experimental therapeutics, Volume: 281, Issue: 3		1997
Role of nitric oxide in tachykinin-induced increase in potential difference of rabbit tracheal mucosa.
The Journal of physiology, Oct-01, Volume: 488 ( Pt 1)		1995
Presence and actions of vasoactive intestinal peptide in the isolated rabbit heart.
Canadian journal of physiology and pharmacology, Volume: 73, Issue: 1		1995
Tachykinin-induced contractions in the circular muscle of guinea pig ileum.
Japanese journal of pharmacology, Volume: 65, Issue: 3		1994
CCK-antagonist L-364,718: influence on rat pancreatic growth induced by caerulein and bombesin-like peptides.
Regulatory peptides, Volume: 24, Issue: 1		1989
Enkephalinase inhibitor potentiates mammalian tachykinin-induced contraction in ferret trachea.
The Journal of pharmacology and experimental therapeutics, Volume: 243, Issue: 3		1987
Receptors for mammalian tachykinins on isolated intestinal smooth muscle cells.
The American journal of physiology, Volume: 249, Issue: 4 Pt 1		1985
Potentiation of tachykinin-induced plasma protein extravasation by calcitonin gene-related peptide.
European journal of pharmacology, Aug-07, Volume: 114, Issue: 1		1985
Involvement of NK1 receptors and importance of the N-terminal sequence of substance P in the stimulation of protein secretion in rat parotid glands.
European journal of pharmacology, Dec-10, Volume: 209, Issue: 1-2		1991
Opioid and neurokinin activities of substance P fragments and their analogs.
European journal of pharmacology, Feb-07, Volume: 193, Issue: 2		1991
[D-Ala1, Leu9-psi-CH2NH-Leu10]neuromedin C antagonizes neuromedin C-stimulated amylase release by acini isolated from the rat pancreas.
Pancreas, Volume: 5, Issue: 4		1990
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]