fenfluramine has been researched along with Pain in 5 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tan-No, K | 1 |
| Takahashi, K | 1 |
| Shimoda, M | 1 |
| Sugawara, M | 1 |
| Nakagawasai, O | 1 |
| Niijima, F | 1 |
| Sato, T | 1 |
| Satoh, S | 1 |
| Tadano, T | 1 |
| Rochat, C | 1 |
| Cervo, L | 1 |
| Romandini, S | 1 |
| Samanin, R | 1 |
| Bell, J | 1 |
| Zhang, XN | 1 |
| Whitaker-Azmitia, PM | 1 |
| Duncan, C | 1 |
| Spencer, PS | 1 |
| Moormann, J | 1 |
| Opitz, K | 1 |
5 other studies available for fenfluramine and Pain
| Article | Year |
|---|---|
S-(+)-fenfluramine-induced nociceptive behavior in mice: Involvement of interactions between spinal serotonin and substance P systems.
Topics: Animals; Fenfluramine; Male; Mice; Morphine; Pain; Serotonin; Serotonin Agents; Spinal Cord; Substan | 2007 |
Differences in the effects of d-fenfluramine and morphine on various responses of rats to painful stimuli.
Topics: Animals; Fenfluramine; Male; Metergoline; Morphine; Pain; Rats; Rats, Inbred Strains; Serotonin; Ste | 1982 |
5-HT3 receptor-active drugs alter development of spinal serotonergic innervation: lack of effect of other serotonergic agents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Biguanides; Female; Fenfluramine; Hypoglycem | 1992 |
Proceedings: An interaction between morphine and fenfluramine in mice.
Topics: Animals; Drug Interactions; Drug Synergism; Fenfluramine; Mice; Morphine; Pain; Skin Tests | 1973 |
[On the analgesic effect of anorectic substances].
Topics: Amphetamine; Animals; Appetite Depressants; Codeine; Diethylpropion; Drug Synergism; Fenfluramine; M | 1967 |