A CD44 molecule that is encoded in the genome of human. [PRO:WCB, UniProtKB:P16070]
CDw44; This protein enables 4 target(s): This protein is located in 11 target(s): This protein is active in 2 target(s): This protein is part of 1 target(s): This protein is involved in 22 target(s):
Epican;
Extracellular matrix receptor III;
ECMR-III;
GP90 lymphocyte homing/adhesion receptor;
HUTCH-I;
Heparan sulfate proteoglycan;
Hermes antigen;
Hyaluronate receptor;
Phagocytic glycoprotein 1;
PGP-1;Research
Bioassay Publications (1)
Timeframe Studies on this Protein(%) All Drugs % pre-1990 0 (0.00) 18.7374 1990's 0 (0.00) 18.2507 2000's 0 (0.00) 29.6817 2010's 1 (100.00) 24.3611 2020's 0 (0.00) 2.80 Compounds (1)
Drugs with Inhibition Measurements
Drug Taxonomy Measurement Average (mM) Bioassay(s) Publication(s) 1,2,3,4-tetrahydroisoquinoline Homo sapiens (human) IC50 27,000.0000 1 1 Drugs with Activation Measurements
Drug Taxonomy Measurement Average (mM) Bioassay(s) Publication(s) 1,2,3,4-tetrahydroisoquinoline Homo sapiens (human) Kd 6,900.0000 1 1 Enables
Target Category Definition protein binding molecular function Binding to a protein. [GOC:go_curators] collagen binding molecular function Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). [GOC:ai, ISBN:0198506732] hyaluronic acid binding molecular function Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine. [GOC:jl] transmembrane signaling receptor activity molecular function Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. [GOC:go_curators, Wikipedia:Transmembrane_receptor] Located In
Target Category Definition Golgi apparatus cellular component A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732] cytosol cellular component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] plasma membrane cellular component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] microvillus cellular component Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. [ISBN:0815316194] focal adhesion cellular component A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] cell surface cellular component The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] apical plasma membrane cellular component The region of the plasma membrane located at the apical end of the cell. [GOC:curators] secretory granule membrane cellular component The lipid bilayer surrounding a secretory granule. [GOC:mah] lamellipodium membrane cellular component The portion of the plasma membrane surrounding a lamellipodium. [GOC:mah] cell projection cellular component A prolongation or process extending from a cell, e.g. a flagellum or axon. [GOC:jl, http://www.cogsci.princeton.edu/~wn/] extracellular exosome cellular component A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] Active In
Target Category Definition basolateral plasma membrane cellular component The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] plasma membrane cellular component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] Part Of
Target Category Definition macrophage migration inhibitory factor receptor complex cellular component A protein complex that binds macrophage migration inhibitory factor. Comprises CD74 and CD44 cell surface proteins. [GOC:BHF, PMID:12782713, PMID:17045821] Involved In
Target Category Definition cell adhesion biological process The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf] cell-matrix adhesion biological process The binding of a cell to the extracellular matrix via adhesion molecules. [GOC:hb] cell migration biological process The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration] cytokine-mediated signaling pathway biological process The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, PMID:19295629] hyaluronan catabolic process biological process The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. [GOC:mah, ISBN:0198506732] positive regulation of peptidyl-serine phosphorylation biological process Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. [GOC:mah] positive regulation of heterotypic cell-cell adhesion biological process Any process that activates or increases the frequency, rate, or extent of heterotypic cell-cell adhesion. [GOC:add] T cell activation biological process The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [GOC:mgi_curators, ISBN:0781735149] negative regulation of apoptotic process biological process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis] negative regulation of cysteine-type endopeptidase activity involved in apoptotic process biological process Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process. [GOC:jl, GOC:mtg_apoptosis] negative regulation of DNA damage response, signal transduction by p53 class mediator biological process Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. [GOC:jl] wound healing, spreading of cells biological process The migration of a cell along or through a wound gap that contributes to the reestablishment of a continuous surface. [GOC:jl] cellular response to fibroblast growth factor stimulus biological process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus. [GOC:jl, GOC:yaf] positive regulation of peptidyl-tyrosine phosphorylation biological process Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. [GOC:ai] cartilage development biological process The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. [GOC:cjm, PMID:23251424] positive regulation of ERK1 and ERK2 cascade biological process Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah] monocyte aggregation biological process The adhesion of one monocyte to one or more other monocytes via adhesion molecules. [GOC:sl, PMID:12972508] cell-cell adhesion biological process The attachment of one cell to another cell via adhesion molecules. [GOC:dos] positive regulation of monocyte aggregation biological process Any process that activates or increases the frequency, rate or extent of monocyte aggregation. [GOC:BHF, GOC:TermGenie] negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator biological process Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. [GOC:TermGenie, PMID:17719541] regulation of lamellipodium morphogenesis biological process Any process that modulates the frequency, rate or extent of lamellipodium morphogenesis. [GOC:mah] inflammatory response biological process The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]