Page last updated: 2024-12-08

mesembrine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID102004683
MeSH IDM0057491

Synonyms (2)

Synonym
mesembrine
FS-7970

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" Despite the wide therapeutic applications of Sceletium extract, there are no reports of in vivo pharmacokinetic properties or analytical methods to quantify these two important alkaloids in plasma."( Quantification of mesembrine and mesembrenone in mouse plasma using UHPLC-QToF-MS: Application to a pharmacokinetic study.
Abe, N; Ashfaq, MK; Avula, B; Khan, IA; Khan, SI; Manda, VK, 2017
)
0.46

Bioavailability

ExcerptReferenceRelevance
" However, comparing the transport of the alkaloids with that of the reference compounds, there are indications that transport across the membranes of the oral cavity may contribute considerably to the overall bioavailability of the alkaloids, depending on pre-systemic metabolism, when the plant material is chewed and kept in the mouth for prolonged periods."( In vitro permeation of mesembrine alkaloids from Sceletium tortuosum across porcine buccal, sublingual, and intestinal mucosa.
Chen, W; Combrinck, S; Gericke, N; Hamman, JH; Shikanga, EA; Viljoen, AM, 2012
)
0.38
" However, the oral bioavailability of these alkaloids was poor and the plasma levels were below the detection limits."( Quantification of mesembrine and mesembrenone in mouse plasma using UHPLC-QToF-MS: Application to a pharmacokinetic study.
Abe, N; Ashfaq, MK; Avula, B; Khan, IA; Khan, SI; Manda, VK, 2017
)
0.46

Dosage Studied

ExcerptRelevanceReference
" Sceletium is marketed through health shops and on the internet as dried plant powder and as pharmaceutical dosage forms."( A capillary zone electrophoresis method for the assay and quality control of mesembrine in Sceletium tablets.
Kanfer, I; Patnala, S, 2008
)
0.35
" Sceletium is presently marketed through health shops and on the internet as dried plant powder and as pharmaceutical dosage forms and purported to be useful in the treatment of psychological disorders."( HPLC analysis of mesembrine-type alkaloids in Sceletium plant material used as an African traditional medicine.
Kanfer, I; Patnala, S, 2010
)
0.36
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (28)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (3.57)18.7374
1990's0 (0.00)18.2507
2000's9 (32.14)29.6817
2010's15 (53.57)24.3611
2020's3 (10.71)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews4 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other24 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]