| Condition | Indicated | Relationship Strength | Studies | Trials |
|---|
Chronic Motor and Vocal Tic Disorder
[description not available] | 0 | 2.31 | 1 | 0 |
Tourette Syndrome
A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79) | 0 | 2.31 | 1 | 0 |
Cognitive Decline
[description not available] | 0 | 2.69 | 2 | 0 |
Fever of Unknown Origin
Fever in which the etiology cannot be ascertained. | 0 | 2.31 | 1 | 0 |
Atherosclerotic Parkinsonism
[description not available] | 0 | 4.76 | 7 | 1 |
Action Tremor
[description not available] | 0 | 3.25 | 5 | 0 |
Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Disorder characterized by symptoms of CATATONIA; HYPOVENTILATION; DYSKINESIAS; ENCEPHALITIS; and SEIZURES followed by a reduced CONSCIOUSNESS. It is often followed by a viral-like prodrome. Many cases are self-limiting and respond well to IMMUNOMODULATORY THERAPIES against the NMDA RECEPTORS antibodies. | 0 | 2.31 | 1 | 0 |
Parkinson Disease, Secondary
Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42) | 0 | 4.76 | 7 | 1 |
Tremor
Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE. | 0 | 3.25 | 5 | 0 |
Cognitive Dysfunction
Diminished or impaired mental and/or intellectual function. | 0 | 2.69 | 2 | 0 |
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. | 0 | 4.11 | 14 | 0 |
Absence Seizure Disorder
[description not available] | 0 | 2.41 | 1 | 0 |
Absence Seizure
[description not available] | 0 | 2.41 | 1 | 0 |
Epilepsy, Absence
A seizure disorder usually occurring in childhood characterized by rhythmic electrical brain discharges of generalized onset. Clinical features include a sudden cessation of ongoing activity usually without loss of postural tone. Rhythmic blinking of the eyelids or lip smacking frequently accompanies the SEIZURES. The usual duration is 5-10 seconds, and multiple episodes may occur daily. Juvenile absence epilepsy is characterized by the juvenile onset of absence seizures and an increased incidence of myoclonus and tonic-clonic seizures. (Menkes, Textbook of Child Neurology, 5th ed, p736) | 0 | 2.41 | 1 | 0 |
Seizures
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder. | 0 | 2.41 | 1 | 0 |
Blood Poisoning
[description not available] | 0 | 2.25 | 1 | 0 |
Sepsis Associated Delirium
[description not available] | 0 | 2.25 | 1 | 0 |
Sepsis
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK. | 0 | 2.25 | 1 | 0 |
Idiopathic Parkinson Disease
[description not available] | 0 | 14.88 | 121 | 46 |
Parkinson Disease
A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75) | 0 | 14.88 | 121 | 46 |
Encephalomyelitis, Inflammatory
[description not available] | 0 | 2.31 | 1 | 0 |
Catatonic Rigidity
[description not available] | 0 | 2.74 | 3 | 0 |
Myoclonic Jerk
[description not available] | 0 | 2.31 | 1 | 0 |
Autoimmune Diseases of the Nervous System
Disorders caused by cellular or humoral immune responses primarily directed towards nervous system autoantigens. The immune response may be directed towards specific tissue components (e.g., myelin) and may be limited to the central nervous system (e.g., MULTIPLE SCLEROSIS) or the peripheral nervous system (e.g., GUILLAIN-BARRE SYNDROME). | 0 | 2.31 | 1 | 0 |
Encephalomyelitis
A general term indicating inflammation of the BRAIN and SPINAL CORD, often used to indicate an infectious process, but also applicable to a variety of autoimmune and toxic-metabolic conditions. There is significant overlap regarding the usage of this term and ENCEPHALITIS in the literature. | 0 | 2.31 | 1 | 0 |
Muscle Rigidity
Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73) | 0 | 2.74 | 3 | 0 |
Microscopic Colitis
[description not available] | 0 | 2.31 | 1 | 0 |
Colitis, Microscopic
A condition characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. This syndrome was first described in 1980 by Read and associates. Subtypes include COLLAGENOUS COLITIS and LYMPHOCYTIC COLITIS. Both have similar clinical symptoms and are distinguishable only by histology. | 0 | 2.31 | 1 | 0 |
Debility
[description not available] | 0 | 2.15 | 1 | 0 |
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. | 0 | 3.61 | 3 | 0 |
Autosomal Dominant Juvenile Parkinson Disease
[description not available] | 0 | 4.88 | 12 | 0 |
Parkinsonian Disorders
A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA. | 0 | 4.88 | 12 | 0 |
Adult Spinal Muscular Atrophy
[description not available] | 0 | 2.15 | 1 | 0 |
Muscular Atrophy, Spinal
A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary. (Adams et al., Principles of Neurology, 6th ed, p1089) | 0 | 2.15 | 1 | 0 |
Central Pontine Myelinolysis
[description not available] | 0 | 2.45 | 2 | 0 |
Chorea Disorders
[description not available] | 0 | 2.17 | 1 | 0 |
Clinically Isolated CNS Demyelinating Syndrome
[description not available] | 0 | 2.17 | 1 | 0 |
Akinetic Autism
[description not available] | 0 | 2.17 | 1 | 0 |
Athetoid Movements
[description not available] | 0 | 2.17 | 1 | 0 |
Acute Disease
Disease having a short and relatively severe course. | 0 | 2.7 | 3 | 0 |
Chorea
Involuntary, forcible, rapid, jerky movements that may be subtle or become confluent, markedly altering normal patterns of movement. Hypotonia and pendular reflexes are often associated. Conditions which feature recurrent or persistent episodes of chorea as a primary manifestation of disease are referred to as CHOREATIC DISORDERS. Chorea is also a frequent manifestation of BASAL GANGLIA DISEASES. | 0 | 2.17 | 1 | 0 |
Demyelinating Diseases
Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system. | 0 | 2.17 | 1 | 0 |
Gastroenteritis
INFLAMMATION of any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM. Causes of gastroenteritis are many including genetic, infection, HYPERSENSITIVITY, drug effects, and CANCER. | 0 | 2.17 | 1 | 0 |
Hyponatremia
Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed) | 0 | 2.17 | 1 | 0 |
Dyskinesia, Medication-Induced
[description not available] | 0 | 5.22 | 19 | 0 |
Dyskinesia, Drug-Induced
Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199) | 0 | 5.22 | 19 | 0 |
Benign Psychomotor Epilepsy, Childhood
[description not available] | 0 | 2.21 | 1 | 0 |
Hyperactivity, Motor
[description not available] | 0 | 4.32 | 4 | 1 |
Dyskinesia Syndromes
[description not available] | 0 | 7.44 | 18 | 8 |
Epilepsy, Temporal Lobe
A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the TEMPORAL LOBE, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic. (From Adams et al., Principles of Neurology, 6th ed, p321). | 0 | 2.21 | 1 | 0 |
Movement Disorders
Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions. | 0 | 7.44 | 18 | 8 |
Encephalitis, Viral
Inflammation of brain parenchymal tissue as a result of viral infection. Encephalitis may occur as primary or secondary manifestation of TOGAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS; PARAMYXOVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RETROVIRIDAE INFECTIONS; and ARENAVIRIDAE INFECTIONS. | 0 | 2.21 | 1 | 0 |
Alarm Clock Headache
[description not available] | 0 | 2.21 | 1 | 0 |
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) | 0 | 3.87 | 2 | 1 |
MPTP Neurotoxicity Syndrome
[description not available] | 0 | 2.79 | 3 | 0 |
Lennox-Gastaut Syndrome
[description not available] | 0 | 2.08 | 1 | 0 |
Acute Brain Injuries
[description not available] | 0 | 2.08 | 1 | 0 |
Aura
[description not available] | 0 | 2.08 | 1 | 0 |
Deficiency, Mental
[description not available] | 0 | 2.08 | 1 | 0 |
Cryptogenic Infantile Spasms
[description not available] | 0 | 2.08 | 1 | 0 |
Brain Injuries
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits. | 0 | 2.08 | 1 | 0 |
Epilepsy
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313) | 0 | 2.08 | 1 | 0 |
Intellectual Disability
Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28) | 0 | 2.08 | 1 | 0 |
Spasms, Infantile
An epileptic syndrome characterized by the triad of infantile spasms, hypsarrhythmia, and arrest of psychomotor development at seizure onset. The majority present between 3-12 months of age, with spasms consisting of combinations of brief flexor or extensor movements of the head, trunk, and limbs. The condition is divided into two forms: cryptogenic (idiopathic) and symptomatic (secondary to a known disease process such as intrauterine infections; nervous system abnormalities; BRAIN DISEASES, METABOLIC, INBORN; prematurity; perinatal asphyxia; TUBEROUS SCLEROSIS; etc.). (From Menkes, Textbook of Child Neurology, 5th ed, pp744-8) | 0 | 2.08 | 1 | 0 |
Lennox Gastaut Syndrome
A childhood-onset epilepsy syndrome. | 0 | 2.08 | 1 | 0 |
Frigidity
[description not available] | 0 | 2.08 | 1 | 0 |
Sexual Dysfunctions, Psychological
Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked distress and interpersonal difficulty. (APA, DSM-IV, 1994) | 0 | 2.08 | 1 | 0 |
Abnormal Movements
[description not available] | 0 | 6.04 | 5 | 2 |
Apoplexy
[description not available] | 0 | 5.05 | 3 | 1 |
Lymphocytopenia
[description not available] | 0 | 2.1 | 1 | 0 |
Lymphopenia
Reduction in the number of lymphocytes. | 0 | 2.1 | 1 | 0 |
Stroke
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810) | 0 | 5.05 | 3 | 1 |
Amentia
[description not available] | 0 | 3.84 | 2 | 0 |
Hallucination of Body Sensation
[description not available] | 0 | 3.01 | 1 | 0 |
Dementia
An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness. | 0 | 3.84 | 2 | 0 |
Hallucinations
Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real. They may be of organic origin or associated with MENTAL DISORDERS. | 0 | 3.01 | 1 | 0 |
Inadequate Sleep
[description not available] | 0 | 2.1 | 1 | 0 |
Hypersomnia, Post-Traumatic
[description not available] | 0 | 2.1 | 1 | 0 |
Cerebral Infarction, Middle Cerebral Artery
[description not available] | 0 | 3.4 | 2 | 0 |
Infarction, Middle Cerebral Artery
NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction. | 0 | 3.4 | 2 | 0 |
Hyperhomocysteinemia
Condition in which the plasma levels of homocysteine and related metabolites are elevated ( | 0 | 2.52 | 2 | 0 |
Nerve Degeneration
Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways. | 0 | 2.11 | 1 | 0 |
Multiple System Atrophy Syndrome
[description not available] | 0 | 2.13 | 1 | 0 |
Multiple System Atrophy
A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92) | 0 | 2.13 | 1 | 0 |
Dystonia
An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77) | 0 | 2.91 | 4 | 0 |
Gastric Stasis
[description not available] | 0 | 2.05 | 1 | 0 |
Gastroparesis
Chronic delayed gastric emptying. Gastroparesis may be caused by motor dysfunction or paralysis of STOMACH muscles or may be associated with other systemic diseases such as DIABETES MELLITUS. | 0 | 2.05 | 1 | 0 |
Basedow Disease
[description not available] | 0 | 2.05 | 1 | 0 |
Hyperthyroid
[description not available] | 0 | 2.05 | 1 | 0 |
Graves Disease
A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy). | 0 | 2.05 | 1 | 0 |
Hyperthyroidism
Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE. | 0 | 2.05 | 1 | 0 |
Agitation, Psychomotor
[description not available] | 0 | 2.05 | 1 | 0 |
Psychomotor Agitation
A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug toxicity or other conditions. | 0 | 2.05 | 1 | 0 |
Depression
Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders. | 0 | 3.36 | 2 | 0 |
Cirrhosis
[description not available] | 0 | 2.06 | 1 | 0 |
Anemia
A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN. | 0 | 2.06 | 1 | 0 |
Fibrosis
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury. | 0 | 2.06 | 1 | 0 |
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. | 0 | 3.61 | 3 | 0 |
Restless Leg Syndrome
[description not available] | 0 | 4.37 | 1 | 1 |
Restless Legs Syndrome
A disorder characterized by aching or burning sensations in the lower and rarely the upper extremities that occur prior to sleep or may awaken the patient from sleep. | 0 | 4.37 | 1 | 1 |
Aqueductal Stenosis
[description not available] | 0 | 2.06 | 1 | 0 |
Benign Meningeal Neoplasms
[description not available] | 0 | 2.06 | 1 | 0 |
Angioblastic Meningioma
[description not available] | 0 | 2.06 | 1 | 0 |
Developmental Psychomotor Disorders
[description not available] | 0 | 2.06 | 1 | 0 |
Aprosodia
[description not available] | 0 | 2.06 | 1 | 0 |
Meningeal Neoplasms
Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord. | 0 | 2.06 | 1 | 0 |
Meningioma
A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7) | 0 | 2.06 | 1 | 0 |
Long Sleeper Syndrome
[description not available] | 0 | 4.75 | 2 | 1 |
Sleep Wake Disorders
Abnormal sleep-wake schedule or pattern associated with the CIRCADIAN RHYTHM which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle. | 0 | 4.75 | 2 | 1 |
Child Development Deviations
[description not available] | 0 | 2.07 | 1 | 0 |
Decreased Muscle Tone
[description not available] | 0 | 2.07 | 1 | 0 |
Nervous System Disorders
[description not available] | 0 | 2.07 | 1 | 0 |
BH4 Deficiency
[description not available] | 0 | 2.07 | 1 | 0 |
Developmental Disabilities
Disorders in which there is a delay in development based on that expected for a given age level or stage of development. These impairments or disabilities originate before age 18, may be expected to continue indefinitely, and constitute a substantial impairment. Biological and nonbiological factors are involved in these disorders. (From American Psychiatric Glossary, 6th ed) | 0 | 2.07 | 1 | 0 |
Nervous System Diseases
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle. | 0 | 2.07 | 1 | 0 |
Phenylketonurias
A group of autosomal recessive disorders marked by a deficiency of the hepatic enzyme PHENYLALANINE HYDROXYLASE or less frequently by reduced activity of DIHYDROPTERIDINE REDUCTASE (i.e., atypical phenylketonuria). Classical phenylketonuria is caused by a severe deficiency of phenylalanine hydroxylase and presents in infancy with developmental delay; SEIZURES; skin HYPOPIGMENTATION; ECZEMA; and demyelination in the central nervous system. (From Adams et al., Principles of Neurology, 6th ed, p952). | 0 | 2.07 | 1 | 0 |
Colonic Inertia
Symptom characterized by the passage of stool once a week or less. | 0 | 3.46 | 1 | 1 |
Urination Disorders
Abnormalities in the process of URINE voiding, including bladder control, frequency of URINATION, as well as the volume and composition of URINE. | 0 | 3.46 | 1 | 1 |
Constipation
Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections. | 0 | 3.46 | 1 | 1 |
Cerebral Ischemia
[description not available] | 0 | 3.41 | 1 | 1 |
Brain Ischemia
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION. | 0 | 3.41 | 1 | 1 |
Acute Confusional Senile Dementia
[description not available] | 0 | 3.32 | 2 | 0 |
Dementia Praecox
[description not available] | 0 | 2.02 | 1 | 0 |
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) | 0 | 3.32 | 2 | 0 |
Schizophrenia
A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior. | 0 | 2.02 | 1 | 0 |
Adverse Drug Event
[description not available] | 0 | 3.42 | 1 | 1 |
Symptom Cluster
[description not available] | 0 | 4.33 | 2 | 2 |
Syndrome
A characteristic symptom complex. | 0 | 4.33 | 2 | 2 |
Drug-Related Side Effects and Adverse Reactions
Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals. | 0 | 3.42 | 1 | 1 |
Lipidoses
Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved. | 0 | 3.34 | 1 | 1 |
Psychoses, Drug
[description not available] | 0 | 4.6 | 3 | 2 |
Drug Withdrawal Symptoms
[description not available] | 0 | 1.98 | 1 | 0 |
Substance Withdrawal Syndrome
Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug. | 0 | 1.98 | 1 | 0 |
Anochlesia
[description not available] | 0 | 2.39 | 2 | 0 |
Amblyopia, Developmental
[description not available] | 0 | 3.37 | 1 | 1 |
Amblyopia
A nonspecific term referring to impaired vision. Major subcategories include stimulus deprivation-induced amblyopia and toxic amblyopia. Stimulus deprivation-induced amblyopia is a developmental disorder of the visual cortex. A discrepancy between visual information received by the visual cortex from each eye results in abnormal cortical development. STRABISMUS and REFRACTIVE ERRORS may cause this condition. Toxic amblyopia is a disorder of the OPTIC NERVE which is associated with ALCOHOLISM, tobacco SMOKING, and other toxins and as an adverse effect of the use of some medications. | 0 | 3.37 | 1 | 1 |
Cystic Fibrosis of Pancreas
[description not available] | 0 | 2 | 1 | 0 |
Cystic Fibrosis
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION. | 0 | 2 | 1 | 0 |
Complications, Pregnancy
[description not available] | 0 | 3.3 | 2 | 0 |
Nausea
An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses. | 0 | 3.34 | 1 | 1 |
Clasp-Knife Spasticity
[description not available] | 0 | 1.98 | 1 | 0 |
Atrophy
Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes. | 0 | 1.98 | 1 | 0 |
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments. | 0 | 1.98 | 1 | 0 |
Muscle Spasticity
A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a free interval) followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54) | 0 | 1.98 | 1 | 0 |
ANS (Autonomic Nervous System) Diseases
[description not available] | 0 | 1.97 | 1 | 0 |
Pyrexia
[description not available] | 0 | 1.97 | 1 | 0 |
Fever
An abnormal elevation of body temperature, usually as a result of a pathologic process. | 0 | 1.97 | 1 | 0 |
Ache
[description not available] | 0 | 1.96 | 1 | 0 |
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS. | 0 | 1.96 | 1 | 0 |
Bewilderment
[description not available] | 0 | 1.96 | 1 | 0 |
Depression, Endogenous
[description not available] | 0 | 2.37 | 2 | 0 |
Chronic Insomnia
[description not available] | 0 | 1.96 | 1 | 0 |
Depressive Disorder
An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent. | 0 | 2.37 | 2 | 0 |
Sleep Initiation and Maintenance Disorders
Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition. | 0 | 1.96 | 1 | 0 |
Affective Psychosis, Bipolar
[description not available] | 0 | 1.97 | 1 | 0 |
Bipolar Disorder
A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence. | 0 | 1.97 | 1 | 0 |
Cramp
[description not available] | 0 | 1.96 | 1 | 0 |
Muscle Cramp
A sustained and usually painful contraction of muscle fibers. This may occur as an isolated phenomenon or as a manifestation of an underlying disease process (e.g., UREMIA; HYPOTHYROIDISM; MOTOR NEURON DISEASE; etc.). (From Adams et al., Principles of Neurology, 6th ed, p1398) | 0 | 1.96 | 1 | 0 |
Cholera Infantum
[description not available] | 0 | 3.33 | 1 | 1 |