3-chloro-4,4-dimethyl-2-oxazolidinone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3-chloro-4,4-dimethyl-2-oxazolidinone: chloramine disinfectant & aflatoxin B detoxicant [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	92357
CHEMBL ID	1770164
SCHEMBL ID	1685266
MeSH ID	M0110813

Synonyms (10)

Synonym
2-oxazolidinone,3-chloro-4,4-dimethyl-
agent i
58629-01-9
3-chloro-4,4-dimethyl-2-oxazolidinone
CHEMBL1770164
3-cdo
2-oxazolidinone, 3-chloro-4,4-dimethyl-
HUPNLWZFGMGNKB-UHFFFAOYSA-N
SCHEMBL1685266
DTXSID60207336

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (7)

Assay ID	Title	Year	Journal	Article
AID594369	Therapeutic index, ratio of CT50 for mouse L929 cells to Candida albicans ATCC 10231	2011	Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10	Novel 3-chlorooxazolidin-2-ones as antimicrobial agents.
AID594368	Therapeutic index, ratio of CT50 for mouse L929 cells to Staphylococcus aureus ATCC 29213	2011	Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10	Novel 3-chlorooxazolidin-2-ones as antimicrobial agents.
AID594363	Antibacterial activity against Staphylococcus aureus ATCC 29213 at pH 7 by CLSI M26A method	2011	Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10	Novel 3-chlorooxazolidin-2-ones as antimicrobial agents.
AID594362	Antibacterial activity against Escherichia coli ATCC 25922 at pH 7 by CLSI M26A method	2011	Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10	Novel 3-chlorooxazolidin-2-ones as antimicrobial agents.
AID594367	Therapeutic index, ratio of CT50 for mouse L929 cells to Escherichia coli ATCC 25922	2011	Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10	Novel 3-chlorooxazolidin-2-ones as antimicrobial agents.
AID594364	Antifungal activity against Candida albicans ATCC 10231 at pH 7 by CLSI M26A method	2011	Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10	Novel 3-chlorooxazolidin-2-ones as antimicrobial agents.
AID594365	Cytotoxicity against mouse L929 cells after 1 hr at pH 7 by Dojindo cell proliferation assay	2011	Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10	Novel 3-chlorooxazolidin-2-ones as antimicrobial agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	16 (76.19)	18.7374
1990's	1 (4.76)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (9.52)	24.3611
2020's	2 (9.52)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.34

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.34 (24.57)
Research Supply Index	3.18 (2.92)
Research Growth Index	4.52 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.34)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	23 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
ddt 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane: structure in first source	1.93	1	benzenoid aromatic compound; chlorophenylethane; monochlorobenzenes; organochlorine insecticide	bridged diphenyl acaricide; carcinogenic agent; endocrine disruptor; persistent organic pollutant
sulfanilamide [no description available]	1.94	1	substituted aniline; sulfonamide antibiotic; sulfonamide	antibacterial agent; drug allergen; EC 4.2.1.1 (carbonic anhydrase) inhibitor
phenothiazine 10H-phenothiazine : The 10H-tautomer of phenothiazine.	1.93	1	phenothiazine	ferroptosis inhibitor; plant metabolite; radical scavenger
oxazoles Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.	3.47	8	1,3-oxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
pyrimidine pyrimidine : The parent compound of the pyrimidines; a diazine having the two nitrogens at the 1- and 3-positions.	1.94	1	diazine; pyrimidines	Daphnia magna metabolite
streptomycin [no description available]	1.93	1	antibiotic antifungal drug; antibiotic fungicide; streptomycins	antibacterial drug; antifungal agrochemical; antimicrobial agent; antimicrobial drug; bacterial metabolite; protein synthesis inhibitor
bromine Bromine: A halogen with the atomic symbol Br, atomic number 35, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.	1.97	1	diatomic bromine
calcium hypochlorite calcium hypochlorite: structure	2.66	3	calcium salt; inorganic calcium salt	bleaching agent
chlorine Chlorine: An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family.	2.37	2	diatomic chlorine; gas molecular entity	bleaching agent
oxazolidin-2-one Oxazolidinones: Derivatives of oxazolidin-2-one. They represent an important class of synthetic antibiotic agents.. oxazolidin-2-one : An oxazolidinone that is 1,3-oxazolidine with an oxo substituent at position 2.. oxazolidinone : An oxazolidine containing one or more oxo groups.	4.3	20	carbamate ester; oxazolidinone	metabolite
aflatoxin b1 Aflatoxin B1: A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.. aflatoxin B1 : An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.	1.96	1	aflatoxin; aromatic ether; aromatic ketone	carcinogenic agent; human metabolite

Condition	Relationship Strength	Studies
Cancer of Kidney [description not available]	2.31	1
Complication, Postoperative [description not available]	2.31	1
Kidney Neoplasms Tumors or cancers of the KIDNEY.	2.31	1
Postoperative Complications Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.	2.31	1
Cancer of Lung [description not available]	2.31	1
Bone Diseases Diseases of BONES.	2.31	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.31	1
Dentin Hypersensitivity [description not available]	2.17	1
Ache [description not available]	2.17	1
Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	2.17	1
Koch's Disease [description not available]	1.93	1
Pulmonary Consumption [description not available]	1.93	1
Tuberculosis Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.	1.93	1
Tuberculosis, Pulmonary MYCOBACTERIUM infections of the lung.	1.93	1
Rheumatism [description not available]	1.93	1
Rheumatic Diseases Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement.	1.93	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	1.96	1

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