Page last updated: 2024-12-07

anatoxin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

anatoxin a: found in Anabaena; was indexed to cyanobacterial toxin (MARINE TOXINS) 1978-2006; also see anatoxin-a(s) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

anatoxin I: found mainly in ANABAENA; was indexed to cyanobacterial toxin (MARINE TOXINS). isolated from many salt-tolerant freshwater cyanobacteria [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID431734
CHEMBL ID25619
CHEBI ID2706
SCHEMBL ID160708
MeSH IDM0063926
PubMed CID3034748
CHEMBL ID2332144
SCHEMBL ID13589890
MeSH IDM0063926

Synonyms (58)

Synonym
1-(9-azabicyclo[4.2.1]non-2-en-2-yl)-ethanone
anatoxin-a
anatoxin a
ethanone, 1-(9-azabicyclo(4.2.1)non-2-en-2-yl)-, (1r)-
C10841 ,
NCGC00162392-01
NCGC00162392-02
(+)-anatoxin
chebi:2706 ,
CHEMBL25619 ,
1-(9-azabicyclo[4.2.1]non-4-en-5-yl)ethanone
AC1L8S0X ,
1-(9-azabicyclo[4.2.1]non-2-en-2-yl)ethanone
bdbm50023330
anatoxin-a,(+)
1-(9-aza-bicyclo[4.2.1]non-2-en-2-yl)-ethanone
SCHEMBL160708
2-acetyl-9-azabicyclo [4.2.1]non-2-ene
2-acetyl-9-azabicyclo[4.2.1]non-2-ene
SGNXVBOIDPPRJJ-UHFFFAOYSA-N
85514-42-7
surecn160708
Q3303006
(+/-)-2-acetyl-9-azabicyclo[4.2.1]non-2-enefumarate
ethanone,1-(9-azabicyclo[4.2.1]non-2-en-2-yl)-(9ci)
DTXSID301338831
ethanone, 1-(1r,6r)-9-azabicyclo(4.2.1)non-2-en-2-yl-
brn 5477454
antx-a
anatoxin i
64285-06-9
anatoxin
PDSP1_000464
AKOS006275277
bdbm50428369
unii-80023a73nk
80023a73nk ,
(+)-anatoxin alpha
hsdb 7750
(+/-)-anatoxin a
anatoxin a [mi]
(+)-anatoxin a
1-(9-azabicyclo(4.2.1)non-2-en-2-yl)ethan-1-one
anatoxin a [hsdb]
1-((1r,6r)-9-azabicyclo(4.2.1)non-4-en-5-yl)ethanone
1-(9-azabicyclo(4.2.1)non-4-en-5-yl)ethanone
(+)-anatoxin .alpha.
CHEMBL2332144 ,
(+)-anatoxin-a
SCHEMBL13589890
4p0 ,
1-[(1r,6r)-9-azabicyclo[4.2.1]non-2-en-2-yl]ethanone
1-((1r,6r,e)-9-azabicyclo[4.2.1]non-2-en-2-yl)ethanone
1-[(1r,6r)-9-azabicyclo[4.2.1]non-2-en-2-yl]ethan-1-one
DTXSID50867064
(+)-anatoxina
anatoxin-a calibration solution crm
anatoxin-a calibration solution crm(0.5ml/ampoule)

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" and oral LD50 values of two ANTX-a producing Anabaena sp."( Effect of route of exposure and repeated doses on the acute toxicity in mice of the cyanobacterial nicotinic alkaloid anatoxin-a.
Krieger, RI; Stevens, DK, 1991
)
0.28
" Adverse effects included a dose-dependent transient narcosis, edema and loss of equilibrium."( Potential developmental toxicity of anatoxin-a, a cyanobacterial toxin.
Chernoff, N; Hall, LL; Herkovits, J; Hunter, ES; Moser, VC; Muñoz, L; Phillips, PM; Rogers, EH,
)
0.13
" Toxic cyanobacteria are found worldwide in inland and coastal water environments."( Toxic effects of anatoxin-a on testes and sperm counts of male mice.
Ates, U; Karaaslan, MA; Sayim, F; Uyanikgil, Y; Yavasoglu, A; Yavasoglu, NU, 2008
)
0.35
" On the basis of evaluated toxicity units, the cyanobacterial extract was classified at class IV toxicity, which means high toxic hazard."( Toxicity of cyanobacterial bloom in the eutrophic dam reservoir (Southeast Poland).
Bownik, A; Kalinowska, R; Pawlik-Skowrońska, B; Rymuszka, A; Sierosławska, A; Skowroński, T, 2010
)
0.36
" Anatoxin-a is suspected to have a distinct toxic mechanism depending on physiological and nervous systems in exposed organisms."( Phytotoxic effects of the cyanobacterial neurotoxin anatoxin-a: morphological, physiological and biochemical responses in aquatic macrophyte, Ceratophyllum demersum.
Ha, MH; Pflugmacher, S, 2013
)
0.39
" Although it shows widespread occurrence and is highly toxic to rodents, its mechanisms of action and biotransformation, and effects in fish species are still poorly understood."( Toxic effects of pure anatoxin-a on biomarkers of rainbow trout, Oncorhynchus mykiss.
Carvalho, AP; Guilhermino, L; Guimarães, L; Osswald, J, 2013
)
0.39
" The transdermal patches did not induce any adverse reactions such as erythema and edema on intact skin sites."( Acute dermal irritation, sensitization, and acute toxicity studies of a transdermal patch for prophylaxis against ({+/-}) anatoxin-a poisoning.
Banerjee, S; Chattopadhyay, P; Ghosh, A; Pathak, MP; Singh, S; Veer, V, 2013
)
0.39
" Deaths of wild and domestic animals due to anatoxin-a exposure have been reported following a toxic response that is driven by the inhibition of the acetylcholine receptors at neuromuscular junctions."( Proteomic analysis of anatoxin-a acute toxicity in zebrafish reveals gender specific responses and additional mechanisms of cell stress.
Campos, A; Carneiro, M; Carvalho, AP; Gutiérrez-Praena, D; Osório, H; Vasconcelos, V, 2015
)
0.42
" To assess the toxic effects of anatoxin-a, microcystin-LR and their combined exposure on submerged macrophytes and biofilms, Vallisneria natans was exposed to solutions containing different concentrations of anatoxin-a and microcystin-LR (0."( Combined toxic effects of anatoxin-a and microcystin-LR on submerged macrophytes and biofilms.
Gu, P; Li, Q; Luo, X; Zhang, C; Zhang, H; Zhang, J; Zheng, Z, 2020
)
0.56
"Global warming and eutrophication may lead to increased incidence of harmful algal blooms and related production of cyanotoxins that can be toxic to aquatic plants."( Phytotoxic effects of microcystins, anatoxin-a and cylindrospermopsin to aquatic plants: A meta-analysis.
Munoz, G; Sauvé, S; Vo Duy, S; Zhang, Y, 2022
)
0.72
" Despite the toxic effects produced by Anatoxin-a (ATX-a), this neurotoxin has been less studied compared to microcystins (MCs) and cylindrospermopsin (CYN)."( Toxic Effects Produced by Anatoxin-a under Laboratory Conditions: A Review.
Cameán, AM; Jos, A; Plata-Calzado, C; Prieto, AI, 2022
)
0.72

Dosage Studied

ExcerptRelevanceReference
" Animals dosed at 800 micrograms/kg did not have return of neuromuscular function and died despite mechanical ventilation, suggesting a lethal mechanism(s) of action in addition to respiratory paralysis."( Electromyographic assessment of the neuromuscular blockade produced in vivo by anatoxin-a in the rat.
Beasley, VR; Schaeffer, DJ; Valentine, WM, 1991
)
0.28
" Electromyographic activity recorded from the diaphragms of rats (n = 5) during continuous toxin administration revealed an increase in muscular electrical activity that became more random and finally decreased prior to death, suggesting a toxin-induced neuromuscular blockade in vivo which ultimately was the cause of death of the anatoxin-a(s) dosed rats."( Pathophysiologic effects of anatoxin-a(s) in anaesthetized rats: the influence of atropine and artificial respiration.
Beasley, VR; Carmichael, WW; Cook, WO; Iwamoto, GA; Schaeffer, DJ, 1990
)
0.28
" The dose-response curve was shifted to the right with increasing agonist concentrations."( Differential inhibition by alpha-conotoxin-MII of the nicotinic stimulation of [3H]dopamine release from rat striatal synaptosomes and slices.
Harvey, SC; Kaiser, SA; Luetje, CW; Soliakov, L; Wonnacott, S, 1998
)
0.3
" And the gene expression of c-fos presented dose-response and time-effect relation."( [The immediate early genes expression in the PC12 cells activated by anatoxin-a].
Qu, WD; Zhang, ZH; Zhu, HG, 2005
)
0.33
" Dose-response data suggested about the same range of toxicity of FBS and FLI samples (EC50  = 0."( Pharmacological studies confirm neurotoxic metabolite(s) produced by the bloom-forming Cylindrospermopsis raciborskii in Hungary.
Farkas, A; Győri, J; Kovács, AW; Szabó, H; Vasas, G; Vehovszky, Á, 2015
)
0.42
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
tropane alkaloid
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (20)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency1.41250.011212.4002100.0000AID1030
regulator of G-protein signaling 4Homo sapiens (human)Potency0.07520.531815.435837.6858AID504845
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Acetylcholine receptor subunit alphaTetronarce californica (Pacific electric ray)IC50 (µMol)0.00060.00010.06770.3000AID145837; AID145838
Acetylcholine receptor subunit betaTetronarce californica (Pacific electric ray)IC50 (µMol)0.00060.00010.06770.3000AID145837; AID145838
Acetylcholine receptor subunit gammaTetronarce californica (Pacific electric ray)IC50 (µMol)0.00060.00010.06770.3000AID145837; AID145838
Acetylcholine receptor subunit deltaTetronarce californica (Pacific electric ray)IC50 (µMol)0.00060.00010.06770.3000AID145837; AID145838
Neuronal acetylcholine receptor subunit alpha-3Rattus norvegicus (Norway rat)IC50 (µMol)0.00900.00300.77706.0000AID145669; AID145670
Neuronal acetylcholine receptor subunit alpha-3Rattus norvegicus (Norway rat)Ki0.02540.00000.352210.0000AID146159
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)IC50 (µMol)0.00900.00030.30952.3000AID145669; AID145670
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)Ki0.00120.00000.12345.5000AID146455; AID3056
Neuronal acetylcholine receptor subunit alpha-2Rattus norvegicus (Norway rat)IC50 (µMol)0.00900.00300.03470.1000AID145669; AID145670
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)IC50 (µMol)0.00900.00030.32092.3000AID145669; AID145670
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)Ki0.00120.00000.10825.5000AID146455; AID3056
Neuronal acetylcholine receptor subunit beta-3Rattus norvegicus (Norway rat)IC50 (µMol)0.00900.00200.02680.1000AID145669; AID145670
Neuronal acetylcholine receptor subunit beta-4Rattus norvegicus (Norway rat)IC50 (µMol)0.00900.00300.88696.0000AID145669; AID145670
Neuronal acetylcholine receptor subunit beta-4Rattus norvegicus (Norway rat)Ki0.02540.00000.296310.0000AID146159
Neuronal acetylcholine receptor subunit beta-2Homo sapiens (human)Ki0.00110.00000.11173.5400AID704939
Neuronal acetylcholine receptor subunit alpha-5Rattus norvegicus (Norway rat)IC50 (µMol)0.00900.00300.03470.1000AID145669; AID145670
Neuronal acetylcholine receptor subunit alpha-6Rattus norvegicus (Norway rat)IC50 (µMol)0.00900.00200.69046.0000AID145669; AID145670
Neuronal acetylcholine receptor subunit alpha-9Rattus norvegicus (Norway rat)IC50 (µMol)0.00900.00240.03010.1000AID145669; AID145670
Neuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)Ki0.00110.00000.11573.5400AID704939
Neuronal acetylcholine receptor subunit alpha-7Rattus norvegicus (Norway rat)IC50 (µMol)0.00900.00301.69437.0795AID145669; AID145670
Neuronal acetylcholine receptor subunit alpha-7Rattus norvegicus (Norway rat)Ki1.14000.00000.73078.0000AID146931
Neuronal acetylcholine receptor subunit alpha-10Rattus norvegicus (Norway rat)IC50 (µMol)0.00900.00300.03470.1000AID145669; AID145670
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)Ki0.00030.00000.12345.5000AID735349
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)Ki0.00030.00000.10825.5000AID735349
Neuronal acetylcholine receptor subunit beta-2Homo sapiens (human)Ki0.00030.00000.11173.5400AID735349
Neuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)Ki0.09100.00221.742710.0000AID735346
Neuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)Ki0.00030.00000.11573.5400AID735349
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Neuronal acetylcholine receptor subunit alpha-3Rattus norvegicus (Norway rat)EC50 (µMol)0.83670.00001.011610.0000AID145659; AID146157
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)EC50 (µMol)0.08930.01402.272410.0000AID145659; AID146320
Neuronal acetylcholine receptor subunit alpha-2Rattus norvegicus (Norway rat)EC50 (µMol)0.11000.10002.104010.0000AID145659
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)EC50 (µMol)0.08930.01402.310410.0000AID145659; AID146320
Neuronal acetylcholine receptor subunit beta-3Rattus norvegicus (Norway rat)EC50 (µMol)0.11000.04601.761010.0000AID145659
Neuronal acetylcholine receptor subunit beta-4Rattus norvegicus (Norway rat)EC50 (µMol)0.83670.00001.010110.0000AID145659; AID146157
Neuronal acetylcholine receptor subunit alpha-5Rattus norvegicus (Norway rat)EC50 (µMol)0.11000.10002.104010.0000AID145659
Neuronal acetylcholine receptor subunit alpha-6Rattus norvegicus (Norway rat)EC50 (µMol)0.11000.04601.761010.0000AID145659
Neuronal acetylcholine receptor subunit alpha-9Rattus norvegicus (Norway rat)EC50 (µMol)0.11000.10002.104010.0000AID145659
Neuronal acetylcholine receptor subunit alpha-7Rattus norvegicus (Norway rat)EC50 (µMol)0.11000.00021.848110.0000AID145659
Neuronal acetylcholine receptor subunit alpha-10Rattus norvegicus (Norway rat)EC50 (µMol)0.11000.10002.104010.0000AID145659
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (71)

Processvia Protein(s)Taxonomy
response to hypoxiaNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
monoatomic ion transportNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
calcium ion transportNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
smooth muscle contractionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
signal transductionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
synaptic transmission, cholinergicNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
visual perceptionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
sensory perception of soundNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
learningNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
memoryNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
locomotory behaviorNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
associative learningNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
visual learningNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
regulation of dopamine secretionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
sensory perception of painNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
vestibulocochlear nerve developmentNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
optic nerve morphogenesisNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
lateral geniculate nucleus developmentNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
central nervous system projection neuron axonogenesisNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
positive regulation of B cell proliferationNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
regulation of synaptic transmission, dopaminergicNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
positive regulation of dopamine secretionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
monoatomic ion transmembrane transportNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
response to nicotineNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
behavioral response to nicotineNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
social behaviorNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
regulation of dopamine metabolic processNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
B cell activationNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
response to cocaineNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
regulation of circadian sleep/wake cycle, REM sleepNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
response to ethanolNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
negative regulation of action potentialNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
regulation of dendrite morphogenesisNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
nervous system processNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
cognitionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
membrane depolarizationNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
regulation of synapse assemblyNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
excitatory postsynaptic potentialNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
synaptic transmission involved in micturitionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
acetylcholine receptor signaling pathwayNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
response to acetylcholineNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
chemical synaptic transmissionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
action potentialNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
response to hypoxiaNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
DNA repairNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
monoatomic ion transportNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
calcium ion transportNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
response to oxidative stressNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
signal transductionNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
chemical synaptic transmissionNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
synaptic transmission, cholinergicNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
regulation of dopamine secretionNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
sensory perception of painNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
monoatomic ion transmembrane transportNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
response to nicotineNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
behavioral response to nicotineNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
B cell activationNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
regulation of membrane potentialNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
nervous system processNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
cognitionNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
membrane depolarizationNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
excitatory postsynaptic potentialNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
inhibitory postsynaptic potentialNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
acetylcholine receptor signaling pathwayNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
response to hypoxiaNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
monoatomic ion transportNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
calcium ion transportNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
smooth muscle contractionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
signal transductionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
synaptic transmission, cholinergicNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
visual perceptionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
sensory perception of soundNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
learningNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
memoryNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
locomotory behaviorNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
associative learningNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
visual learningNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
regulation of dopamine secretionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
sensory perception of painNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
vestibulocochlear nerve developmentNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
optic nerve morphogenesisNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
lateral geniculate nucleus developmentNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
central nervous system projection neuron axonogenesisNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
positive regulation of B cell proliferationNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
regulation of synaptic transmission, dopaminergicNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
positive regulation of dopamine secretionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
monoatomic ion transmembrane transportNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
response to nicotineNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
behavioral response to nicotineNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
social behaviorNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
regulation of dopamine metabolic processNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
B cell activationNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
response to cocaineNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
regulation of circadian sleep/wake cycle, REM sleepNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
response to ethanolNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
negative regulation of action potentialNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
regulation of dendrite morphogenesisNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
nervous system processNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
cognitionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
membrane depolarizationNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
regulation of synapse assemblyNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
excitatory postsynaptic potentialNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
synaptic transmission involved in micturitionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
acetylcholine receptor signaling pathwayNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
response to acetylcholineNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
chemical synaptic transmissionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
negative regulation of tumor necrosis factor productionNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
response to hypoxiaNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
positive regulation of protein phosphorylationNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
monoatomic ion transportNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
calcium ion transportNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
intracellular calcium ion homeostasisNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
signal transductionNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
synaptic transmission, cholinergicNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
learning or memoryNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
memoryNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
short-term memoryNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
positive regulation of cell population proliferationNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
negative regulation of tumor necrosis factor productionNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
monoatomic ion transmembrane transportNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
response to nicotineNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
positive regulation of MAPK cascadeNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
positive regulation of angiogenesisNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
synapse organizationNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
cognitionNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
sensory processingNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
positive regulation of protein metabolic processNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
excitatory postsynaptic potentialNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
calcium ion transmembrane transportNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
acetylcholine receptor signaling pathwayNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
dendritic spine organizationNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
modulation of excitatory postsynaptic potentialNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
dendrite arborizationNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
positive regulation of long-term synaptic potentiationNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
positive regulation of amyloid-beta formationNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
negative regulation of amyloid-beta formationNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
regulation of amyloid precursor protein catabolic processNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
response to amyloid-betaNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
response to acetylcholineNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
regulation of amyloid fibril formationNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
positive regulation of CoA-transferase activityNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
positive regulation of excitatory postsynaptic potentialNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
regulation of membrane potentialNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
chemical synaptic transmissionNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
action potentialNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
response to hypoxiaNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
DNA repairNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
monoatomic ion transportNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
calcium ion transportNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
response to oxidative stressNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
signal transductionNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
chemical synaptic transmissionNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
synaptic transmission, cholinergicNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
regulation of dopamine secretionNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
sensory perception of painNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
monoatomic ion transmembrane transportNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
response to nicotineNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
behavioral response to nicotineNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
B cell activationNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
regulation of membrane potentialNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
nervous system processNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
cognitionNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
membrane depolarizationNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
excitatory postsynaptic potentialNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
inhibitory postsynaptic potentialNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
acetylcholine receptor signaling pathwayNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (14)

Processvia Protein(s)Taxonomy
protein bindingNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
ligand-gated monoatomic ion channel activityNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
acetylcholine receptor activityNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
acetylcholine-gated monoatomic cation-selective channel activityNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
acetylcholine bindingNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
protein-containing complex bindingNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
quaternary ammonium group bindingNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
heterocyclic compound bindingNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
protein bindingNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
ligand-gated monoatomic ion channel activityNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
acetylcholine receptor activityNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
acetylcholine-gated monoatomic cation-selective channel activityNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
acetylcholine bindingNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
protein bindingNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
ligand-gated monoatomic ion channel activityNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
acetylcholine receptor activityNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
acetylcholine-gated monoatomic cation-selective channel activityNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
acetylcholine bindingNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
protein-containing complex bindingNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
quaternary ammonium group bindingNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
heterocyclic compound bindingNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
amyloid-beta bindingNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
monoatomic ion channel activityNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
calcium channel activityNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
protein bindingNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
acetylcholine receptor activityNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
toxic substance bindingNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
chloride channel regulator activityNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
acetylcholine-gated monoatomic cation-selective channel activityNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
acetylcholine bindingNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
protein homodimerization activityNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
protein bindingNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
ligand-gated monoatomic ion channel activityNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
acetylcholine receptor activityNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
acetylcholine-gated monoatomic cation-selective channel activityNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
acetylcholine bindingNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (14)

Processvia Protein(s)Taxonomy
plasma membraneNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
external side of plasma membraneNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
membraneNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
presynaptic membraneNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
plasma membrane raftNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
cholinergic synapseNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
postsynaptic specialization membraneNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
acetylcholine-gated channel complexNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
plasma membraneNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
neuron projectionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
synapseNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
plasma membraneNeuronal acetylcholine receptor subunit alpha-9Rattus norvegicus (Norway rat)
plasma membraneNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
external side of plasma membraneNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
membraneNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
dendriteNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
neuronal cell bodyNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
postsynaptic membraneNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
acetylcholine-gated channel complexNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
synapseNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
neuron projectionNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
plasma membraneNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
plasma membraneNeuronal acetylcholine receptor subunit alpha-10Rattus norvegicus (Norway rat)
plasma membraneNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
external side of plasma membraneNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
membraneNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
presynaptic membraneNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
plasma membrane raftNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
cholinergic synapseNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
postsynaptic specialization membraneNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
acetylcholine-gated channel complexNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
plasma membraneNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
neuron projectionNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
synapseNeuronal acetylcholine receptor subunit beta-2Homo sapiens (human)
plasma membraneNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
membraneNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
plasma membrane raftNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
postsynaptic membraneNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
postsynapseNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
acetylcholine-gated channel complexNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
plasma membraneNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
neuron projectionNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
synapseNeuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)
plasma membraneNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
external side of plasma membraneNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
membraneNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
dendriteNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
neuronal cell bodyNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
postsynaptic membraneNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
acetylcholine-gated channel complexNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
synapseNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
neuron projectionNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
plasma membraneNeuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (36)

Assay IDTitleYearJournalArticle
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID146455Binding affinity at rat brain Nicotinic acetylcholine receptor alpha4-beta22002Journal of medicinal chemistry, Jul-18, Volume: 45, Issue:15
Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.
AID146152Compound was tested for its potency at Nicotinic acetylcholine receptor alpha3-beta4 relative to that of Nicotinic acetylcholine receptor alpha4-beta22002Journal of medicinal chemistry, Jul-18, Volume: 45, Issue:15
Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.
AID145839Potency relative to PHT in torpedo electroplax membranes ([3H]MCC binding)1988Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids.
AID25815Ionization constant was determined1985Journal of medicinal chemistry, Sep, Volume: 28, Issue:9
Synthetic and conformational studies on anatoxin-a: a potent acetylcholine agonist.
AID145838inhibition of (-)-[3H]nicotine binding to torpedo electroplax membranes1988Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids.
AID146157Activation potency at Nicotinic acetylcholine receptor alpha3beta4, expressed as concentration required to achieve a half maximal activation2002Journal of medicinal chemistry, Jul-18, Volume: 45, Issue:15
Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.
AID145840Potency relative to PHT in torpedo electroplax membranes ([3H]nicotine binding)1988Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids.
AID220029Ability to stimulate catechloamine release in bovine adrenal chromaffin cells1997Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
AID145663Binding affinity towards nicotinic acetylcholine receptor using [125I]alpha-bungarotoxin as radioligand in rat forebrain homogenates2003Bioorganic & medicinal chemistry letters, Nov-03, Volume: 13, Issue:21
Rigidified acetylcholine mimics: conformational requirements for binding to neuronal nicotinic receptors.
AID145659Compound was evaluated for functional potency and efficacy at rat Nicotinic acetylcholine receptor subtype DA release1997Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
AID3056In vitro binding affinity towards (alpha-4)2(beta-2)3 neuronal nicotinic acetylcholine receptor in P2 membrane fractions of rat forebrain2003Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
3D QSAR analyses-guided rational design of novel ligands for the (alpha4)2(beta2)3 nicotinic acetylcholine receptor.
AID146149Binding affinity to Nicotinic acetylcholine receptor alpha3-beta4 using +/-[3H]epibatidine as radioligand in pig adrenal gland2002Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5
Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165.
AID71788Agonist efficacy was evaluated as concentration that produces 10-m V depolarization in frog sartorius muscle; activity value ranges from 0.2-0.41985Journal of medicinal chemistry, Sep, Volume: 28, Issue:9
Synthetic and conformational studies on anatoxin-a: a potent acetylcholine agonist.
AID146159Binding affinity at rat brain Nicotinic acetylcholine receptor alpha3-beta42002Journal of medicinal chemistry, Jul-18, Volume: 45, Issue:15
Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.
AID145828Potency relative to PHT in rat brain membranes ([3H]MCC binding)1988Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids.
AID178953Effective dose required to produce prostration after injection into rat's fourth ventricle1988Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids.
AID146931Binding affinity at rat brain Nicotinic acetylcholine receptor alpha72002Journal of medicinal chemistry, Jul-18, Volume: 45, Issue:15
Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.
AID145837Inhibition of [3H]MCC binding to torpedo electroplax membranes1988Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids.
AID145666Binding affinity towards nicotinic acetylcholine receptor using [3H]-cytisine as radioligand in rat forebrain homogenates2003Bioorganic & medicinal chemistry letters, Nov-03, Volume: 13, Issue:21
Rigidified acetylcholine mimics: conformational requirements for binding to neuronal nicotinic receptors.
AID146320Compound was evaluated for functional potency and efficacy at human Nicotinic acetylcholine receptor alpha4-beta21997Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
AID146483Binding affinity to Nicotinic acetylcholine receptor alpha4-beta2 using +/-[3H]epibatidine as radioligand in rat brain2002Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5
Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165.
AID704939Binding affinity to alpha4beta2 nAChR2012Journal of medicinal chemistry, Nov-08, Volume: 55, Issue:21
Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders.
AID146936Binding affinity to subtype Nicotinic acetylcholine receptor alpha7 using [3H]-MLA as radioligand in rat brain2002Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5
Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165.
AID229789Ratio of Ki (binding affinity) relative to activation potency2002Journal of medicinal chemistry, Jul-18, Volume: 45, Issue:15
Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.
AID145670Inhibition of [3H]MCC binding to rat brain membranes1988Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids.
AID145669Inhibition of (-)-[3H]nicotine binding to rat brain membranes1988Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids.
AID146794Compound was tested for its potency at Nicotinic acetylcholine receptor alpha-7 relative to that of Nicotinic acetylcholine receptor alpha4-beta22002Journal of medicinal chemistry, Jul-18, Volume: 45, Issue:15
Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.
AID145829Potency relative to PHT in rat brain membranes ([3H]nicotine binding)1988Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids.
AID189548Potency for prostration assay, relative to PHT1988Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids.
AID735346Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR (unknown origin)2013Journal of natural products, Apr-26, Volume: 76, Issue:4
(+)-Laburnamine, a natural selective ligand and partial agonist for the α4β2 nicotinic receptor subtype.
AID735349Displacement of [3H]nicotine from alpha4beta2 nAChR (unknown origin)2013Journal of natural products, Apr-26, Volume: 76, Issue:4
(+)-Laburnamine, a natural selective ligand and partial agonist for the α4β2 nicotinic receptor subtype.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (486)

TimeframeStudies, This Drug (%)All Drugs %
pre-1990228 (46.91)18.7374
1990's43 (8.85)18.2507
2000's76 (15.64)29.6817
2010's98 (20.16)24.3611
2020's41 (8.44)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Trials0 (0.00%)5.53%
Reviews16 (3.07%)6.00%
Reviews0 (0.00%)6.00%
Case Studies3 (0.57%)4.05%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Observational0 (0.00%)0.25%
Other503 (96.36%)84.16%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]