Page last updated: 2024-11-05

trimebutine and Pain

trimebutine has been researched along with Pain in 3 studies

Trimebutine: Proposed spasmolytic with possible local anesthetic action used in gastrointestinal disorders.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"Trimebutine is a weak opioid receptor agonist used in the treatment of IBS."5.35A nitro-arginine derivative of trimebutine (NO2-Arg-Trim) attenuates pain induced by colorectal distension in conscious rats. ( Caliendo, G; Distrutti, E; Fiorucci, S; Mencarelli, A; Renga, B; Santagada, V; Severino, B, 2009)
"Trimebutine (2-dimethylamino-2-phenylbutyl 3,4,5-trimethoxybenzoate, hydrogen maleate) relieves abdominal pain in humans."3.70Antinociceptive effect of (S)-N-desmethyl trimebutine against a mechanical stimulus in a rat model of peripheral neuropathy. ( Christensen, D; Guilbaud, G; Kayser, V; Roman, F, 2000)
"Trimebutine is a weak opioid receptor agonist used in the treatment of IBS."1.35A nitro-arginine derivative of trimebutine (NO2-Arg-Trim) attenuates pain induced by colorectal distension in conscious rats. ( Caliendo, G; Distrutti, E; Fiorucci, S; Mencarelli, A; Renga, B; Santagada, V; Severino, B, 2009)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's0 (0.00)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Makarova, AA2
Diukova, GM2
Ruchkina, IN2
Romashkina, NV2
Indejkina, LK2
Degterev, DA2
Dbar, SR2
Parfenov, AI2
Distrutti, E1
Mencarelli, A1
Renga, B1
Caliendo, G1
Santagada, V1
Severino, B1
Fiorucci, S1
Kayser, V1
Christensen, D1
Guilbaud, G1
Roman, F1

Trials

1 trial available for trimebutine and Pain

ArticleYear
[Visceral sensitivity in diagnostics and treatment of severe irritated bowel syndrome].
    Terapevticheskii arkhiv, 2022, Sep-05, Volume: 94, Issue:2S

    Topics: Adult; Diarrhea; Duloxetine Hydrochloride; Female; Humans; Irritable Bowel Syndrome; Male; Pain; Ser

2022
[Visceral sensitivity in diagnostics and treatment of severe irritated bowel syndrome].
    Terapevticheskii arkhiv, 2022, Sep-05, Volume: 94, Issue:2S

    Topics: Adult; Diarrhea; Duloxetine Hydrochloride; Female; Humans; Irritable Bowel Syndrome; Male; Pain; Ser

2022
[Visceral sensitivity in diagnostics and treatment of severe irritated bowel syndrome].
    Terapevticheskii arkhiv, 2022, Sep-05, Volume: 94, Issue:2S

    Topics: Adult; Diarrhea; Duloxetine Hydrochloride; Female; Humans; Irritable Bowel Syndrome; Male; Pain; Ser

2022
[Visceral sensitivity in diagnostics and treatment of severe irritated bowel syndrome].
    Terapevticheskii arkhiv, 2022, Sep-05, Volume: 94, Issue:2S

    Topics: Adult; Diarrhea; Duloxetine Hydrochloride; Female; Humans; Irritable Bowel Syndrome; Male; Pain; Ser

2022

Other Studies

2 other studies available for trimebutine and Pain

ArticleYear
A nitro-arginine derivative of trimebutine (NO2-Arg-Trim) attenuates pain induced by colorectal distension in conscious rats.
    Pharmacological research, 2009, Volume: 59, Issue:5

    Topics: Animals; Colitis; Colon; Dilatation, Pathologic; Gastrointestinal Agents; Gene Expression Profiling;

2009
Antinociceptive effect of (S)-N-desmethyl trimebutine against a mechanical stimulus in a rat model of peripheral neuropathy.
    Life sciences, 2000, Volume: 66, Issue:5

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Hindlimb; Male; Naloxone; Narcotic Antagonist

2000