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Free fatty acid receptor 1
A free fatty acid receptor 1 that is encoded in the genome of rat. [OMA:Q8K3T4, PRO:DNx]
Synonyms
G-protein coupled receptor 40
Research
Bioassay Publications (6)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (4)
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| gw9508 | Rattus norvegicus (Norway rat) | EC50 | 0.0990 | 1 | 1 |
| tak-875 | Rattus norvegicus (Norway rat) | EC50 | 9.0250 | 3 | 3 |
| amg-837 | Rattus norvegicus (Norway rat) | EC50 | 0.0131 | 2 | 2 |
| am 1638 | Rattus norvegicus (Norway rat) | EC50 | 0.0114 | 1 | 1 |
Discovery of a GPR40 Superagonist: The Impact of Aryl Propionic Acid α-Fluorination.ACS medicinal chemistry letters, , Jan-10, Volume: 10, Issue:1, 2019
The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470).Journal of medicinal chemistry, , 12-22, Volume: 59, Issue:24, 2016
[no title available]ACS medicinal chemistry letters, , Dec-08, Volume: 7, Issue:12, 2016
The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470).Journal of medicinal chemistry, , 12-22, Volume: 59, Issue:24, 2016
AMG 837: a potent, orally bioavailable GPR40 agonist.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 22, Issue:2, 2012