| Assay ID | Title | Year | Journal | Article |
|---|
| AID146778 | Compound was evaluated for functional activation from channel currents at human Nicotinic acetylcholine receptor alpha-7 expressed in oocytes. | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID246935 | Analgesic activity of compound in phase I mouse formalin activities at a dose range of 0.4-3.1 mg, s.c. | 2005 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 15, Issue:6
| 3-(2,5-Dihydro-1H-pyrrol-2-ylmethoxy)pyridines: synthesis and analgesic activity. |
| AID208880 | Compound was evaluated for functional activation to [86Rb+] efflux From human medulloblastoma cell line TE671 expressing recombinant alpha-1-beta-1-gamma delta receptors. | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID145980 | Ability to displace radioligand [3H](-)-cytisine from Neuronal nicotinic receptor in rat brain membrane was determined. | 2002 | Bioorganic & medicinal chemistry letters, Nov-18, Volume: 12, Issue:22
| Synthesis and biological evaluation of pyridine-modified analogues of 3-(2-aminoethoxy)pyridine as novel nicotinic receptor ligands. |
| AID219642 | Compound was evaluated for its ability to displace [125 I]alpha-bungarotoxin (alpha-BgT) from torpedo alpha1-beta1-gamma1 electroplax | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID57848 | Compound was evaluated for increase in diastolic blood pressure (BP) in dog at 10 nM/Kg when administered intravenously | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID242876 | Maximal response against Nicotinic acetylcholine receptor alpha3-beta4 | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. |
| AID146611 | Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 in rat brain using [3H]-cytisine as radioligand | 1998 | Bioorganic & medicinal chemistry letters, Oct-06, Volume: 8, Issue:19
| Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice. |
| AID225721 | Functional activation of human sympathetic ganglionic type nAChRs in IMR-32 cells containing alpha-3 subtype | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID146788 | Compound was evaluated for its ability to displace [125I]alpha-bungarotoxin (alpha-BgT) from K28 cells expressing human Nicotinic acetylcholine receptor alpha7 | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID132954 | Compound was evaluated for the analgesic activity by mouse hotplate assay at the doses of 0.062 and 0.62 | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID417953 | Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assay | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors. |
| AID146301 | Compound was evaluated for its ability to displace [3H]cytisine from K177 cells expressing human Nicotinic acetylcholine receptor alpha4-beta2 | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID225722 | Intrinsic activity against human sympathetic ganglionic type nAChRs in IMR-32 cells containing alpha-3 subtype | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID94464 | Compound was evaluated for functional activation to [86Rb+] efflux from human K177 cells expressing recombinant alpha4-beta2 receptors. | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID133110 | Minimum intraperitoneal effective dose for abdominal constriction in mouse | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID58452 | Compound was evaluated for increase in heart rate (HR) in dog at 10 nM/Kg when administered intravenously | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID242872 | Maximal response against Nicotinic acetylcholine receptor alpha 7 | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. |
| AID417950 | Displacement of [3H]cytisine from alpha4beta2 nAChR in rat brain membrane | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors. |
| AID246940 | Analgesic activity of compound in phase II mouse formalin activities at a dose range of 0.4-3.1 mg, s.c. | 2005 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 15, Issue:6
| 3-(2,5-Dihydro-1H-pyrrol-2-ylmethoxy)pyridines: synthesis and analgesic activity. |
| AID417952 | Agonist activity at human recombinant alpha4beta2 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assay relative to nicotine | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors. |
| AID132950 | Analgesic activity in a mouse hot plate assay | 1998 | Bioorganic & medicinal chemistry letters, Oct-06, Volume: 8, Issue:19
| Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice. |
| AID145686 | Compound was evaluated for its ability to displace [3H]-cytisine binding from high-affinity Nicotinic acetylcholine receptor in rat brain (principally the alpha4-beta2 nAChR subtype) | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID209004 | Compound was evaluated for functional activation to [86Rb+] efflux From human medulloblastoma cell line TE671 expressing recombinant alpha-1-beta-1-gamma delta receptors. | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID417954 | Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assay relative to nicotine | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors. |
| AID242877 | Maximal response against Nicotinic acetylcholine receptor alpha4-beta2 | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. |
| AID146777 | Compound was evaluated for functional activation from channel currents at human Nicotinic acetylcholine receptor alpha-7 expressed in oocytes. | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID133111 | Minimum peroral effective dose for analgesic activity was determined by mouse hot plate assay | 1998 | Journal of medicinal chemistry, Feb-12, Volume: 41, Issue:4
| Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
| AID417951 | Agonist activity at human recombinant alpha4beta2 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assay | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors. |
| AID1346592 | Rat nicotinic acetylcholine receptor alpha4 subunit (Nicotinic acetylcholine receptors) | 1998 | The Journal of pharmacology and experimental therapeutics, May, Volume: 285, Issue:2
| ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |