true-blue has been researched along with Pain* in 2 studies
2 other study(ies) available for true-blue and Pain
Article | Year |
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Dopaminergic input to GABAergic neurons in the rostral agranular insular cortex of the rat.
Increasing evidence shows that the rostral agranular insular cortex (RAIC) is important in the modulation of nociception in humans and rats and that dopamine and GABA appear to be key neurotransmitters in the function of this cortical region. Here we use immunocytochemistry and path tracing to examine the relationship between dopamine and GABA related elements in the RAIC of the rat. We found that the RAIC has a high density of dopamine fibers that arise principally from the ipsilateral ventral tegmental area/substantia nigra (VTA/SN) and from a different set of neurons than those that project to the medial prefrontal cortex. Within the RAIC, there are close appositions between dopamine fibers and GABAergic interneurons. One target of cortical GABA appears to be a dense band of GABAB receptor-bearing neurons located in lamina 5 of the RAIC. The GABAB receptor-bearing neurons project principally to the amygdala and nucleus accumbens with few or no projections to the medial prefrontal cortex, cingulate gyrus, the mediodorsal thalamic nucleus or contralateral RAIC. The current anatomical data, together with previous behavioral results, suggest that part of the dopaminergic modulation of the RAIC occurs through GABAergic interneurons. GABA is able to exert specific effects through its action on GABAB receptor-bearing projection neurons that target a few subcortical limbic structures. Through these connections, dopamine innervation of the RAIC is likely to affect the motivational and affective dimensions of pain. Topics: Animals; Benzofurans; Cerebral Cortex; Dopamine; gamma-Aminobutyric Acid; Immunohistochemistry; Interneurons; Limbic System; Male; Neural Inhibition; Neural Pathways; Pain; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Synaptic Transmission; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2003 |
Convergence of sensory processes from the heart and left ulnar nerve onto a single afferent perikaryon: a neuroanatomical study in the rat employing fluorescent tracers.
After injection of true blue (TB) into the pericardial sac and nuclear yellow (NY) into the left ulnar nerve of rats, most perikarya in the left eighth cervical and first thoracic dorsal root ganglia are single-labeled with either TB or NY. However, 7.1-14.7% of the sensory perikarya from the cardiac area labeled with TB are simultaneously labeled with NY. This finding indicates that some primary sensory perikarya receive processes from both the left arm and the heart. In addition to other mechanisms that may be operative in the referral of pain of cardiac origin to the medial left arm, these results suggest that sensory neurons with dichotomizing somatic and visceral peripheral processes may also contribute to this phenomenon. Topics: Afferent Pathways; Angina Pectoris; Animals; Benzimidazoles; Benzofurans; Female; Ganglia, Spinal; Heart Conduction System; Neurons, Afferent; Pain; Rats; Rats, Inbred Strains; Sensation; Ulnar Nerve | 1986 |