desipramine has been researched along with Pain in 41 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amitriptyline reduces the pain caused by peripheral-nerve disease, but treatment is often limited by side effects related to the drug's many pharmacologic actions." | 9.07 | Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. ( Dubner, R; Lynch, SA; Max, MB; Muir, J; Shoaf, SE; Smoller, B, 1992) |
| " Using pharmacological and transgenic approaches in mice, we evaluated adrenergic receptor (AR) implication in the action of the tricyclic antidepressant desipramine, the noradrenaline and serotonin reuptake inhibitor venlafaxine, and the noradrenaline reuptake inhibitor reboxetine." | 7.75 | Beta2-adrenoceptors are essential for desipramine, venlafaxine or reboxetine action in neuropathic pain. ( Barrot, M; Doridot, S; Freund-Mercier, MJ; Hein, L; Petit-Demoulière, N; Tessier, LH; Yalcin, I, 2009) |
| "Amitriptyline, a non-selective noradrenaline (NA) and 5-hydroxytryptamine (5-HT) reuptake inhibitor, has recently been demonstrated to produce a peripheral antinociceptive action in an inflammatory (formalin test) and a neuropathic pain model (spinal nerve ligation)." | 7.70 | Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. ( Esser, MJ; Reid, AR; Sawynok, J, 1999) |
| "The effects of the specific 5-HT uptake inhibitors alaproclate and zimelidine, the 5-HT releasing compound p-chloroamphetamine (PCA) and the specific NA uptake inhibitor desipramine on pain sensitivity were examined in male rats using the hot-plate and tail-flick methods." | 7.66 | Test-specific effects of the 5-HT reuptake inhibitors alaproclate and zimelidine on pain sensitivity and morphine analgesia. ( Holm, AC; Ogren, SO, 1980) |
| "Imipramine dose was increased in steps of 25 mg/d every second week, and blood samples were taken at every dose." | 6.71 | TDM-based imipramine treatment in neuropathic pain. ( Bach, FW; Jensen, TS; Rasmussen, PV; Sindrup, SH, 2004) |
| "Desipramine has the least anticholinergic and sedative effects of the first generation tricyclic antidepressants." | 6.67 | Efficacy of desipramine in painful diabetic neuropathy: a placebo-controlled trial. ( Dubner, R; Gracely, RH; Kishore-Kumar, R; Max, MB; Meister, B; Schafer, SC; Smoller, B, 1991) |
| "(1) Postherpetic pain is infrequent, but the incidence increases with age." | 5.31 | Gabapentin: new indication. In postherpetic neuralgia when amitriptyline fails. ( , 2002) |
| "Amitriptyline reduces the pain caused by peripheral-nerve disease, but treatment is often limited by side effects related to the drug's many pharmacologic actions." | 5.07 | Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. ( Dubner, R; Lynch, SA; Max, MB; Muir, J; Shoaf, SE; Smoller, B, 1992) |
| "Forty-seven patients with definite rheumatoid arthritis (RA) were treated in a 32 week, double blind, crossover trial of amitriptyline, desipramine, trazodone, and placebo." | 5.06 | Antidepressant analgesia in rheumatoid arthritis. ( Atwood, C; Beck, NC; Brownlee-Duffeck, M; Elliott, TR; Frank, RG; Haut, AE; Kashani, JH; Kay, DR; Parker, JC; Smith, E, 1988) |
| " Using pharmacological and transgenic approaches in mice, we evaluated adrenergic receptor (AR) implication in the action of the tricyclic antidepressant desipramine, the noradrenaline and serotonin reuptake inhibitor venlafaxine, and the noradrenaline reuptake inhibitor reboxetine." | 3.75 | Beta2-adrenoceptors are essential for desipramine, venlafaxine or reboxetine action in neuropathic pain. ( Barrot, M; Doridot, S; Freund-Mercier, MJ; Hein, L; Petit-Demoulière, N; Tessier, LH; Yalcin, I, 2009) |
| " Synthesis and testing of a series of cyclohexanol ethylpiperazines identified ( S)-(-)- 17i (WAY-256805), a potent norepinephrine reuptake inhibitor (IC 50 = 82 nM, K i = 50 nM) that exhibited excellent selectivity over both the serotonin and dopamine transporters and was efficacious in animal models of depression, pain, and thermoregulatory dysfunction." | 3.74 | Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors. ( Belardi, JK; Bray, JA; Burroughs, KD; Cohn, ST; Cosmi, SA; Deecher, DC; Gavrin, LK; Ho, DM; Johnston, GH; Koury, EJ; Leiter, J; Leventhal, L; Mahaney, PE; Mugford, CA; Platt, B; Rosenzweig-Lipson, SJ; Sabatucci, JP; Santilli, AA; Smith, VA; Stack, GP; Trybulski, EJ; Vu, TA; Ye, F; Zhang, Y, 2008) |
| "Amitriptyline, a non-selective noradrenaline (NA) and 5-hydroxytryptamine (5-HT) reuptake inhibitor, has recently been demonstrated to produce a peripheral antinociceptive action in an inflammatory (formalin test) and a neuropathic pain model (spinal nerve ligation)." | 3.70 | Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. ( Esser, MJ; Reid, AR; Sawynok, J, 1999) |
| "Drugs that are clinically effective (mexiletine and desipramine) or ineffective (fluoxetine) in the treatment of human neuropathic pain were evaluated for efficacy in rat models involving central sensitization (i." | 3.69 | The effects of mexiletine, desipramine and fluoxetine in rat models involving central sensitization. ( Hunter, JC; Jett, MF; McGuirk, J; Waligora, D, 1997) |
| "Two patients are described who developed testicular swelling and pain during treatment with desipramine." | 3.67 | Desipramine and testicular swelling in two patients. ( Thienhaus, OJ; Vogel, N, 1988) |
| "The effects of the specific 5-HT uptake inhibitors alaproclate and zimelidine, the 5-HT releasing compound p-chloroamphetamine (PCA) and the specific NA uptake inhibitor desipramine on pain sensitivity were examined in male rats using the hot-plate and tail-flick methods." | 3.66 | Test-specific effects of the 5-HT reuptake inhibitors alaproclate and zimelidine on pain sensitivity and morphine analgesia. ( Holm, AC; Ogren, SO, 1980) |
| "Imipramine dose was increased in steps of 25 mg/d every second week, and blood samples were taken at every dose." | 2.71 | TDM-based imipramine treatment in neuropathic pain. ( Bach, FW; Jensen, TS; Rasmussen, PV; Sindrup, SH, 2004) |
| "Desipramine has the least anticholinergic and sedative effects of the first generation tricyclic antidepressants." | 2.67 | Efficacy of desipramine in painful diabetic neuropathy: a placebo-controlled trial. ( Dubner, R; Gracely, RH; Kishore-Kumar, R; Max, MB; Meister, B; Schafer, SC; Smoller, B, 1991) |
| " With chronic administration each of the antidepressants produced effects which could potentially interfere with CRF function in the LC." | 2.38 | Pharmacology of locus coeruleus spontaneous and sensory-evoked activity. ( Curtis, AL; Valentino, RJ, 1991) |
| " Initial pharmacokinetics evaluation indicated an excellent brain exposure following oral dosing in mice, suggesting that further investigation into the use of alkoxyisoxazoles as σ1 ligands for antinociception is warranted." | 1.43 | Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy. ( Gao, ZB; Gunosewoyo, H; Liu, T; Pang, T; Shi, JJ; Shi, M; Sun, H; Tang, J; Xu, YZ; Yang, F; Yu, LF; Zhang, W; Zheng, YM, 2016) |
| "Desipramine is a potential useful treatment for patients with OAB." | 1.40 | Use of desipramine for the treatment of overactive bladder refractory to antimuscarinic therapy. ( Bagadiya, N; Hillelsohn, JH; Kashan, M; Rais-Bahrami, S; Weiss, GH, 2014) |
| "(1) Postherpetic pain is infrequent, but the incidence increases with age." | 1.31 | Gabapentin: new indication. In postherpetic neuralgia when amitriptyline fails. ( , 2002) |
| "In untreated mice, morphine, fentanyl, clonidine, oxymetazoline, desipramine and lidocaine, but not MK801, produced dose-related antinociception when tested using a 55 degrees C water tail-flick test." | 1.31 | Pharmacologic reversal of pertussis toxin-induced thermal allodynia in mice. ( Shannon, HE; Womer, DE, 2000) |
| "2-fold leftward shift in the antinociceptive dose-response curve (ED50 = 0." | 1.29 | Potentiation of intrathecal DAMGO antinociception, but not gastrointestinal transit inhibition, by 5-hydroxytryptamine and norepinephrine uptake blockade. ( Hornby, PJ; Paul, D, 1995) |
| "If sinusitis is not found to be present, the otolaryngologist must help the patient understand this point, reassure him or her that the otolaryngologist will still be vigilant for the development of sinusitis, and refocus the history and workup for some other cause of the recurrent and persistent paranasal pain." | 1.29 | Treatment of chronic paranasal sinus pain with minimal sinus disease. ( Acquadro, MA; Montgomery, WW, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (36.59) | 18.7374 |
| 1990's | 11 (26.83) | 18.2507 |
| 2000's | 9 (21.95) | 29.6817 |
| 2010's | 5 (12.20) | 24.3611 |
| 2020's | 1 (2.44) | 2.80 |
| Authors | Studies |
|---|---|
| Mahaney, PE | 2 |
| Gavrin, LK | 1 |
| Trybulski, EJ | 2 |
| Stack, GP | 1 |
| Vu, TA | 1 |
| Cohn, ST | 2 |
| Ye, F | 1 |
| Belardi, JK | 1 |
| Santilli, AA | 1 |
| Sabatucci, JP | 1 |
| Leiter, J | 1 |
| Johnston, GH | 2 |
| Bray, JA | 2 |
| Burroughs, KD | 1 |
| Cosmi, SA | 2 |
| Leventhal, L | 2 |
| Koury, EJ | 2 |
| Zhang, Y | 1 |
| Mugford, CA | 1 |
| Ho, DM | 1 |
| Rosenzweig-Lipson, SJ | 1 |
| Platt, B | 1 |
| Smith, VA | 2 |
| Deecher, DC | 2 |
| Vu, AT | 1 |
| Zhang, P | 1 |
| Kim, CY | 1 |
| Harrison, JE | 1 |
| Whiteside, GT | 1 |
| Kennedy, JD | 1 |
| Altenbach, RJ | 1 |
| Black, LA | 1 |
| Strakhova, MI | 1 |
| Manelli, AM | 1 |
| Carr, TL | 1 |
| Marsh, KC | 1 |
| Wetter, JM | 1 |
| Wensink, EJ | 1 |
| Hsieh, GC | 1 |
| Honore, P | 1 |
| Garrison, TR | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Sun, H | 1 |
| Shi, M | 1 |
| Zhang, W | 1 |
| Zheng, YM | 1 |
| Xu, YZ | 1 |
| Shi, JJ | 1 |
| Liu, T | 1 |
| Gunosewoyo, H | 1 |
| Pang, T | 1 |
| Gao, ZB | 1 |
| Yang, F | 1 |
| Tang, J | 1 |
| Yu, LF | 1 |
| Makau, CM | 1 |
| Towett, PK | 1 |
| Kanui, TI | 1 |
| Abelson, KSP | 1 |
| Hillelsohn, JH | 1 |
| Rais-Bahrami, S | 1 |
| Bagadiya, N | 1 |
| Kashan, M | 1 |
| Weiss, GH | 1 |
| Yalcin, I | 1 |
| Tessier, LH | 1 |
| Petit-Demoulière, N | 1 |
| Doridot, S | 1 |
| Hein, L | 1 |
| Freund-Mercier, MJ | 1 |
| Barrot, M | 1 |
| Foster, DC | 1 |
| Beth Kotok, M | 1 |
| Huang, LS | 1 |
| Watts, A | 1 |
| Oakes, D | 1 |
| Howard, FM | 1 |
| Stodgell, CJ | 1 |
| Dworkin, RH | 1 |
| Pamplona, FA | 1 |
| Pandolfo, P | 1 |
| Duarte, FS | 1 |
| Takahashi, RN | 1 |
| Prediger, RD | 1 |
| Wallace, MS | 1 |
| Barger, D | 1 |
| Schulteis, G | 1 |
| Rasmussen, PV | 1 |
| Jensen, TS | 1 |
| Sindrup, SH | 1 |
| Bach, FW | 1 |
| Basile, AS | 1 |
| Janowsky, A | 1 |
| Golembiowska, K | 1 |
| Kowalska, M | 1 |
| Tam, E | 1 |
| Benveniste, M | 1 |
| Popik, P | 1 |
| Nikiforuk, A | 1 |
| Krawczyk, M | 1 |
| Nowak, G | 1 |
| Krieter, PA | 1 |
| Lippa, AS | 1 |
| Skolnick, P | 1 |
| Koustova, E | 1 |
| Kellstein, DE | 1 |
| Malseed, RT | 1 |
| Goldstein, FJ | 1 |
| Ogren, SO | 2 |
| Holm, AC | 1 |
| Berge, OG | 2 |
| Pappas, B | 1 |
| Ings, R | 1 |
| Roberts, D | 1 |
| Lindsay, PG | 1 |
| Wyckoff, M | 1 |
| Mahoney, JE | 1 |
| Gray, SL | 1 |
| Carnes, M | 1 |
| Paul, D | 1 |
| Hornby, PJ | 1 |
| Acquadro, MA | 1 |
| Montgomery, WW | 1 |
| Jett, MF | 1 |
| McGuirk, J | 1 |
| Waligora, D | 1 |
| Hunter, JC | 1 |
| Onal, A | 1 |
| Tuğlular, I | 1 |
| Sawynok, J | 1 |
| Esser, MJ | 1 |
| Reid, AR | 1 |
| McCleane, G | 1 |
| Womer, DE | 1 |
| Shannon, HE | 1 |
| Molina, FJ | 1 |
| Max, MB | 2 |
| Lynch, SA | 1 |
| Muir, J | 1 |
| Shoaf, SE | 1 |
| Smoller, B | 2 |
| Dubner, R | 2 |
| Coquoz, D | 1 |
| Porchet, HC | 1 |
| Dayer, P | 1 |
| Valentino, RJ | 1 |
| Curtis, AL | 1 |
| Kishore-Kumar, R | 1 |
| Schafer, SC | 1 |
| Meister, B | 1 |
| Gracely, RH | 1 |
| Lund, A | 1 |
| Tjølsen, A | 1 |
| Hole, K | 2 |
| Eide, PK | 1 |
| Broch, OJ | 1 |
| Frank, RG | 1 |
| Kashani, JH | 1 |
| Parker, JC | 1 |
| Beck, NC | 1 |
| Brownlee-Duffeck, M | 1 |
| Elliott, TR | 1 |
| Haut, AE | 1 |
| Atwood, C | 1 |
| Smith, E | 1 |
| Kay, DR | 1 |
| Thienhaus, OJ | 1 |
| Vogel, N | 1 |
| Giordano, J | 1 |
| Barr, GA | 1 |
| Sorvino, AR | 1 |
| Bodnar, RJ | 1 |
| Mann, PE | 1 |
| Stone, EA | 1 |
| Saarnivaara, L | 1 |
| Ceraso, OL | 1 |
| Fernández Pardal, J | 1 |
| López, C | 1 |
| Fernández Pardal, MM | 1 |
| Mateos, MD | 1 |
| Opitz, K | 1 |
| Borchert, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Vulvar Vestibulitis Trial: Desipramine-Lidocaine[NCT00276068] | 128 participants (Anticipated) | Interventional | 2002-08-31 | Completed | |||
| Is Low Level Laser Therapy (LLLT) Effective for Reducing Pain Experienced by Women With Provoked Vestibulodynia?[NCT04234542] | 28 participants (Actual) | Interventional | 2021-02-18 | Completed | |||
| Effectiveness and Cost-utility of Somatocognitive Therapy Versus Treatment as Usual for Provoked (Localized) Vestibulodynia - a Randomized Clinical Trial (ProLoVe Study)[NCT04613713] | 128 participants (Anticipated) | Interventional | 2021-01-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for desipramine and Pain
| Article | Year |
|---|---|
Pharmacology of locus coeruleus spontaneous and sensory-evoked activity.
Topics: 1-Naphthylamine; Action Potentials; Animals; Antidepressive Agents; Corticotropin-Releasing Hormone; | 1991 |
7 trials available for desipramine and Pain
| Article | Year |
|---|---|
The tampon test for vulvodynia treatment outcomes research: reliability, construct validity, and responsiveness.
Topics: Adrenergic Uptake Inhibitors; Adult; Anesthetics, Local; Coitus; Desipramine; Diagnostic Techniques, | 2009 |
The tampon test for vulvodynia treatment outcomes research: reliability, construct validity, and responsiveness.
Topics: Adrenergic Uptake Inhibitors; Adult; Anesthetics, Local; Coitus; Desipramine; Diagnostic Techniques, | 2009 |
The tampon test for vulvodynia treatment outcomes research: reliability, construct validity, and responsiveness.
Topics: Adrenergic Uptake Inhibitors; Adult; Anesthetics, Local; Coitus; Desipramine; Diagnostic Techniques, | 2009 |
The tampon test for vulvodynia treatment outcomes research: reliability, construct validity, and responsiveness.
Topics: Adrenergic Uptake Inhibitors; Adult; Anesthetics, Local; Coitus; Desipramine; Diagnostic Techniques, | 2009 |
The tampon test for vulvodynia treatment outcomes research: reliability, construct validity, and responsiveness.
Topics: Adrenergic Uptake Inhibitors; Adult; Anesthetics, Local; Coitus; Desipramine; Diagnostic Techniques, | 2009 |
The tampon test for vulvodynia treatment outcomes research: reliability, construct validity, and responsiveness.
Topics: Adrenergic Uptake Inhibitors; Adult; Anesthetics, Local; Coitus; Desipramine; Diagnostic Techniques, | 2009 |
The tampon test for vulvodynia treatment outcomes research: reliability, construct validity, and responsiveness.
Topics: Adrenergic Uptake Inhibitors; Adult; Anesthetics, Local; Coitus; Desipramine; Diagnostic Techniques, | 2009 |
The tampon test for vulvodynia treatment outcomes research: reliability, construct validity, and responsiveness.
Topics: Adrenergic Uptake Inhibitors; Adult; Anesthetics, Local; Coitus; Desipramine; Diagnostic Techniques, | 2009 |
The tampon test for vulvodynia treatment outcomes research: reliability, construct validity, and responsiveness.
Topics: Adrenergic Uptake Inhibitors; Adult; Anesthetics, Local; Coitus; Desipramine; Diagnostic Techniques, | 2009 |
The effect of chronic oral desipramine on capsaicin-induced allodynia and hyperalgesia: a double-blinded, placebo-controlled, crossover study.
Topics: Adult; Antidepressive Agents, Tricyclic; Capsaicin; Cross-Over Studies; Desipramine; Double-Blind Me | 2002 |
TDM-based imipramine treatment in neuropathic pain.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Desipramine; Dose-Response Relationship, Drug; Drug Monitorin | 2004 |
Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Analgesics; Depression; Desipramine; Diabetic Neuropa | 1992 |
[Central analgesic effects of antidepressant drugs with various mechanisms of action: desipramine, fluvoxamine and moclobemide].
Topics: Analgesics; Antidepressive Agents; Benzamides; Desipramine; Double-Blind Method; Electric Stimulatio | 1991 |
Efficacy of desipramine in painful diabetic neuropathy: a placebo-controlled trial.
Topics: Adult; Aged; Benztropine; Depression; Desipramine; Diabetic Neuropathies; Double-Blind Method; Emoti | 1991 |
Antidepressant analgesia in rheumatoid arthritis.
Topics: Aged; Amitriptyline; Antidepressive Agents; Arthritis, Rheumatoid; Depression; Desipramine; Double-B | 1988 |
33 other studies available for desipramine and Pain
| Article | Year |
|---|---|
Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.
Topics: Animals; Cell Line; Cyclohexanols; Ethylamines; Female; Humans; Male; Mice; Models, Molecular; Molec | 2008 |
1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors.
Topics: Animals; Body Temperature Regulation; Female; Indoles; Magnetic Resonance Spectroscopy; Neurotransmi | 2010 |
Diaryldiamines with dual inhibition of the histamine H(3) receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain.
Topics: Animals; Histamine H3 Antagonists; Naphthols; Norepinephrine Plasma Membrane Transport Proteins; Ost | 2010 |
Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Injecti | 2016 |
Antinociceptive effects of nortriptyline and desipramine hydrochloride in Speke's hinge-back tortoise (Kinixys Spekii).
Topics: Analgesics; Animals; Capsaicin; Desipramine; Formaldehyde; Nortriptyline; Pain; Turtles | 2023 |
Use of desipramine for the treatment of overactive bladder refractory to antimuscarinic therapy.
Topics: Adrenergic Uptake Inhibitors; Aged; Aged, 80 and over; Desipramine; Drug Resistance; Female; Humans; | 2014 |
Beta2-adrenoceptors are essential for desipramine, venlafaxine or reboxetine action in neuropathic pain.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; | 2009 |
Altered emotionality leads to increased pain tolerance in amyloid beta (Abeta1-40) peptide-treated mice.
Topics: Amyloid beta-Peptides; Animals; Behavior, Animal; Cognition; Desipramine; Disease Models, Animal; Dr | 2010 |
Gabapentin: new indication. In postherpetic neuralgia when amitriptyline fails.
Topics: Acetates; Amitriptyline; Anticonvulsants; Desipramine; Drug Approval; France; Herpes Zoster; Humans; | 2002 |
Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain.
Topics: Acute Disease; Analgesics; Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Chronic Disease; | 2007 |
Contrasting effects of acute vs. chronic tricyclic antidepressant treatment on central morphine analgesia.
Topics: Analgesia; Animals; Clomipramine; Desipramine; Male; Morphine; Pain; Periaqueductal Gray; Rats; Rats | 1984 |
Test-specific effects of the 5-HT reuptake inhibitors alaproclate and zimelidine on pain sensitivity and morphine analgesia.
Topics: Alanine; Analgesia; Animals; Behavior, Animal; Brompheniramine; Desipramine; Dose-Response Relations | 1980 |
Limited involvement of central noradrenergic pathways in morphine-induced antinociception.
Topics: Animals; Benzylamines; Desipramine; Drug Interactions; Male; Morphine; Nervous System; Norepinephrin | 1984 |
Neonatal intraspinal 6-hydroxydopamine, 5,7-dihydroxytryptamine or their combination: effects on nociception and morphine analgesia.
Topics: 5,7-Dihydroxytryptamine; Analgesics; Animals; Animals, Newborn; Desipramine; Dihydroxytryptamines; F | 1982 |
The depression-pain syndrome and its response to antidepressants.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Depression; Desipramine; Doxepin; Fem | 1981 |
Prevention and treatment of the complications of diabetes mellitus.
Topics: Aged; Amitriptyline; Desipramine; Diabetic Neuropathies; Humans; Pain | 1995 |
Potentiation of intrathecal DAMGO antinociception, but not gastrointestinal transit inhibition, by 5-hydroxytryptamine and norepinephrine uptake blockade.
Topics: Animals; Desipramine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gastrointestinal Motility; I | 1995 |
Treatment of chronic paranasal sinus pain with minimal sinus disease.
Topics: 1-Naphthylamine; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; Carbamaz | 1996 |
The effects of mexiletine, desipramine and fluoxetine in rat models involving central sensitization.
Topics: Animals; Anti-Arrhythmia Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tr | 1997 |
The relationship between pupil diameter and pain by the administration of morphine and antidepressant drugs in mice.
Topics: Amitriptyline; Analgesia; Analgesics, Opioid; Animals; Antidepressive Agents; Desipramine; Male; Mic | 1999 |
Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat.
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Caffeine; Desipramine; Drug Evaluation, Precli | 1999 |
Peripheral antinociceptive actions of desimipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat.
Topics: Analgesics, Non-Narcotic; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, | 2000 |
Pharmacologic reversal of pertussis toxin-induced thermal allodynia in mice.
Topics: Animals; Carbamazepine; Clonidine; Desipramine; Dizocilpine Maleate; Dose-Response Relationship, Dru | 2000 |
Comments on Max et al., PAIN, 45 (1991) 3-9.
Topics: Desipramine; Humans; Pain | 1992 |
The apparent antinociceptive effect of desipramine and zimelidine in the tail flick test in rats is mainly caused by changes in tail skin temperature.
Topics: Analgesics; Animals; Body Temperature Regulation; Desipramine; Hot Temperature; Male; Pain; Rats; Ra | 1989 |
5-HT depletion with 5,7-DHT, PCA and PCPA in mice: differential effects on the sensitivity to 5-MeODMT, 8-OH-DPAT and 5-HTP as measured by two nociceptive tests.
Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; | 1988 |
Desipramine and testicular swelling in two patients.
Topics: Bipolar Disorder; Depressive Disorder; Desipramine; Humans; Male; Middle Aged; Pain; Testicular Dise | 1988 |
Effects of neonatal spinal cord serotonin depletion on opiate-induced analgesia in tests of thermal and mechanical pain.
Topics: 5,7-Dihydroxytryptamine; Analgesia; Animals; Animals, Newborn; Cyclazocine; Desipramine; Dihydroxytr | 1988 |
Painful postcoital testicular retraction linked with desipramine.
Topics: Adult; Coitus; Depressive Disorder; Desipramine; Humans; Male; Muscle Contraction; Pain; Spasm; Test | 1986 |
Potentiation of cold-water swim analgesia by acute, but not chronic desipramine administration.
Topics: Analgesia; Animals; Body Temperature; Cold Temperature; Desipramine; Male; Pain; Rats; Rats, Inbred | 1985 |
Analgesic activity of some sympathetic drugs and their effect on morphine analgesia in rabbits.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-A | 1969 |
[Agrypnia anesthesia with imipramine and/or desipramine].
Topics: Adult; Chemical Phenomena; Chemistry; Desipramine; Drug Evaluation; Humans; Imipramine; Male; Middle | 1974 |
[On the management of pain using antidepressive agents].
Topics: Amitriptyline; Antidepressive Agents; Desipramine; Humans; Imipramine; Nortriptyline; Pain | 1967 |