Page last updated: 2024-12-07

2',6'-dimethyltyrosine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2',6'-dimethyltyrosine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID124247
CHEMBL ID180386
SCHEMBL ID38374
MeSH IDM0204830

Synonyms (22)

Synonym
l-tyrosine, 2,6-dimethyl-
2',6'-dimethyltyrosine
(2s)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoic acid
CHEMBL180386
l-tyr(2,6-di-me)
(s)-2,6-dimethyltyrosine
2,6-dimethyl-l-tyrosine
123715-02-6
(s)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoic acid
MG-0721
AKOS015890661
SCHEMBL38374
LSNDLIKCFHLFKO-JTQLQIEISA-N
DTXSID80154070
mfcd06659984
CS-W000665
tyrosine, 2,6-dimethyl-
AMY37550
l-2',6'-dimethyltyrosine
Q27459305
(s)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoicacid
HY-W000665

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" This observation can be interpreted as indication that within this dosage range there is an absence of morphine-like subjective effects."( Analogs of the delta opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions.
Anthony, E; Beardsley, PM; Chandrakumar, NS; Drury, B; Lopez, OT; Reichman, M; Savage, MA; Stapelfeld, A; Williamson, LN, 1992
)
0.49
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID243024Ratio of binding affinities for opioid receptors delta 1 and mu 12005Bioorganic & medicinal chemistry letters, Feb-01, Volume: 15, Issue:3
Studies on the structure-activity relationship of 2',6'-dimethyl-l-tyrosine (Dmt) derivatives: bioactivity profile of H-Dmt-NH-CH(3).
AID238336Binding affinity for rat brain opioid receptor delta 12005Bioorganic & medicinal chemistry letters, Feb-01, Volume: 15, Issue:3
Studies on the structure-activity relationship of 2',6'-dimethyl-l-tyrosine (Dmt) derivatives: bioactivity profile of H-Dmt-NH-CH(3).
AID1872049Stability in mouse serum assessed as half life2022Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3
Analgesic Opioid Ligand Discovery Based on Nonmorphinan Scaffolds Derived from Natural Sources.
AID238289Binding affinity for rat brain opioid receptor mu 12005Bioorganic & medicinal chemistry letters, Feb-01, Volume: 15, Issue:3
Studies on the structure-activity relationship of 2',6'-dimethyl-l-tyrosine (Dmt) derivatives: bioactivity profile of H-Dmt-NH-CH(3).
AID1872050Stability in mouse brain homogenate assessed as half life2022Journal of medicinal chemistry, 02-10, Volume: 65, Issue:3
Analgesic Opioid Ligand Discovery Based on Nonmorphinan Scaffolds Derived from Natural Sources.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (27)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (14.81)18.2507
2000's16 (59.26)29.6817
2010's5 (18.52)24.3611
2020's2 (7.41)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 16.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index16.50 (24.57)
Research Supply Index3.33 (2.92)
Research Growth Index4.65 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (16.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (3.70%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other26 (96.30%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]