Page last updated: 2024-10-26

brl 42810 and Pain

brl 42810 has been researched along with Pain in 17 studies

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"This study investigated the safety and efficacy of famciclovir compared to acyclovir in patients with herpes zoster, to determine whether the two regimens are equally effective for the treatment of patients with uncomplicated herpes zoster over a period of 7days."9.27Randomized clinical trial of famciclovir or acyclovir for the treatment of herpes zoster in adults. ( Amazonas, RB; de Oliveira, MFB; Gambero, S; Pott Junior, H, 2018)
"In this randomized, double-blind, multicenter, acyclovir-controlled study, the efficacy and safety of famciclovir were evaluated for the treatment of herpes zoster in patients who were immunocompromised following bone marrow or solid organ transplantation or oncology treatment."9.09A randomized, double-blind trial of famciclovir versus acyclovir for the treatment of localized dermatomal herpes zoster in immunocompromised patients. ( Belanger, R; Bezwoda, W; Boon, R; Ljungman, P; Saltzman, RL; Tyring, S, 2001)
"This study investigated the safety and efficacy of famciclovir compared to acyclovir in patients with herpes zoster, to determine whether the two regimens are equally effective for the treatment of patients with uncomplicated herpes zoster over a period of 7days."5.27Randomized clinical trial of famciclovir or acyclovir for the treatment of herpes zoster in adults. ( Amazonas, RB; de Oliveira, MFB; Gambero, S; Pott Junior, H, 2018)
"In this randomized, double-blind, multicenter, acyclovir-controlled study, the efficacy and safety of famciclovir were evaluated for the treatment of herpes zoster in patients who were immunocompromised following bone marrow or solid organ transplantation or oncology treatment."5.09A randomized, double-blind trial of famciclovir versus acyclovir for the treatment of localized dermatomal herpes zoster in immunocompromised patients. ( Belanger, R; Bezwoda, W; Boon, R; Ljungman, P; Saltzman, RL; Tyring, S, 2001)
"Famciclovir, the well absorbed oral pro-drug of penciclovir, is effective in the treatment of herpes zoster when given three times daily."2.71Once, twice, or three times daily famciclovir compared with aciclovir for the oral treatment of herpes zoster in immunocompetent adults: a randomized, multicenter, double-blind clinical trial. ( Ashton, R; Candaele, D; Decroix, J; Forszpaniak, C; Paulet, C; Shafran, SD; Tyring, SK; Wade, A, 2004)
"In addition, they demonstrated that treatment of acute herpes zoster patients with famciclovir significantly reduces both the duration and prevalence of PHN."2.69Postherpetic neuralgia: impact of famciclovir, age, rash severity, and acute pain in herpes zoster patients. ( Boon, RJ; Dworkin, RH; Griffin, DR; Phung, D, 1998)
"Reactivation of varicella zoster virus (VZV) is a common event in patients undergoing allogeneic bone marrow transplantation (BMT) and may lead to life-threatening complications."2.69Varicella zoster virus infections following allogeneic bone marrow transplantation: frequency, risk factors, and clinical outcome. ( Akhtar, M; DesJardin, J; Griffith, J; Koc, Y; Miller, KB; Schenkein, DP; Snydman, DR, 2000)
"Zoster-associated pain has a complex pathophysiology that begins with viral damage and increased sensitization of peripheral sensory neurons."2.41Understanding pain in herpes zoster: an essential for optimizing treatment. ( Wood, M, 2002)
"Persistent pain is the most debilitating sequela and it occurs in at least 15% of individuals over 50 years of age."2.40Therapeutic approaches to the management of herpes zoster. ( Gnann, JW; Whitley, RJ, 1999)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (35.29)18.2507
2000's8 (47.06)29.6817
2010's2 (11.76)24.3611
2020's1 (5.88)2.80

Authors

AuthorsStudies
Tsunoda, K1
Endo, R1
Pott Junior, H1
de Oliveira, MFB1
Gambero, S1
Amazonas, RB1
Imafuku, S1
Nakayama, J1
Higa, K1
Furue, M1
Takahara, M1
Katayama, I1
Tani, M1
Wood, M1
Jubelt, B1
Shafran, SD1
Tyring, SK1
Ashton, R1
Decroix, J1
Forszpaniak, C1
Wade, A1
Paulet, C1
Candaele, D1
Wassilew, S1
Wassilew, SW1
Boon, RJ3
Griffin, DR3
Pereles, L1
Triscott, J1
Meiring, P1
Dworkin, RH2
Phung, D1
Spruance, SL1
Rowe, NH1
Raborn, GW1
Thibodeau, EA1
D'Ambrosio, JA1
Bernstein, DI1
Whitley, RJ1
Gnann, JW1
Koc, Y1
Miller, KB1
Schenkein, DP1
Griffith, J1
Akhtar, M1
DesJardin, J1
Snydman, DR1
Tyring, S1
Belanger, R1
Bezwoda, W1
Ljungman, P1
Boon, R1
Saltzman, RL1
Nagasako, EM1
Johnson, RW1
Griffin, DRJ1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Prospective, Randomized, Multicenter Study of the Efficacy and Safety of Famciclovir 500 mg Comparing To Aciclovir 400mg in Patients With Herpes Zoster[NCT01327144]Phase 3177 participants (Actual)Interventional2012-06-30Completed
A Randomized, Efficacy Assessor-Blinded, Study to Assess Preliminary Efficacy and Safety of EDTA Eye Drops v. an Active Comparator in the Suppression of Herpes Simplex Virus Eruptions in Subjects With a History of Herpes Labialis[NCT04893577]Phase 220 participants (Anticipated)Interventional2022-01-20Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for brl 42810 and Pain

ArticleYear
Understanding pain in herpes zoster: an essential for optimizing treatment.
    The Journal of infectious diseases, 2002, Oct-15, Volume: 186 Suppl 1

    Topics: 2-Aminopurine; Acyclovir; Analgesics; Antiviral Agents; Chronic Disease; Clinical Trials as Topic; F

2002
[Varicella-zoster virus infections--2: Zoster pain -- therapy and prevention].
    MMW Fortschritte der Medizin, 2006, Volume: Spec no.1

    Topics: 2-Aminopurine; Acute Disease; Acyclovir; Administration, Oral; Adult; Age Factors; Analgesics, Non-N

2006
Efficacy of famciclovir in the treatment of herpes zoster: reduction of pain associated with zoster.
    Neurology, 1995, Volume: 45, Issue:12 Suppl 8

    Topics: 2-Aminopurine; Antiviral Agents; Famciclovir; Herpes Zoster; Humans; Pain; Pain Measurement

1995
Famciclovir: efficacy in zoster and issues in the assessment of pain.
    Advances in experimental medicine and biology, 1996, Volume: 394

    Topics: 2-Aminopurine; Antiviral Agents; Famciclovir; Herpes Zoster; Humans; Pain; Pain Measurement

1996
Therapeutic approaches to the management of herpes zoster.
    Advances in experimental medicine and biology, 1999, Volume: 458

    Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Famciclovir; Herpes Zoster; Humans; Pain; Prednisone; Pr

1999
Acute pain in herpes zoster: the famciclovir database project.
    Pain, 2001, Volume: 94, Issue:1

    Topics: 2-Aminopurine; Acute Disease; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antiviral Age

2001

Trials

8 trials available for brl 42810 and Pain

ArticleYear
Randomized clinical trial of famciclovir or acyclovir for the treatment of herpes zoster in adults.
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2018, Volume: 72

    Topics: 2-Aminopurine; Acyclovir; Adult; Aged; Antiviral Agents; Famciclovir; Female; Herpes Zoster; Herpesv

2018
Valacyclovir and famciclovir therapy in herpes zoster.
    Current neurology and neuroscience reports, 2002, Volume: 2, Issue:6

    Topics: 2-Aminopurine; Acyclovir; Aged; Antiviral Agents; Double-Blind Method; Famciclovir; Gastrointestinal

2002
Once, twice, or three times daily famciclovir compared with aciclovir for the oral treatment of herpes zoster in immunocompetent adults: a randomized, multicenter, double-blind clinical trial.
    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2004, Volume: 29, Issue:4

    Topics: 2-Aminopurine; Acyclovir; Administration, Oral; Adolescent; Adult; Aged; Antiviral Agents; Double-Bl

2004
Brivudin compared with famciclovir in the treatment of herpes zoster: effects in acute disease and chronic pain in immunocompetent patients. A randomized, double-blind, multinational study.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2005, Volume: 19, Issue:1

    Topics: 2-Aminopurine; Acute Disease; Administration, Oral; Aged; Antiviral Agents; Bromodeoxyuridine; Chron

2005
Postherpetic neuralgia: impact of famciclovir, age, rash severity, and acute pain in herpes zoster patients.
    The Journal of infectious diseases, 1998, Volume: 178 Suppl 1

    Topics: 2-Aminopurine; Acute Disease; Age Factors; Antiviral Agents; Double-Blind Method; Exanthema; Famcicl

1998
Peroral famciclovir in the treatment of experimental ultraviolet radiation-induced herpes simplex labialis: A double-blind, dose-ranging, placebo-controlled, multicenter trial.
    The Journal of infectious diseases, 1999, Volume: 179, Issue:2

    Topics: 2-Aminopurine; Administration, Oral; Adolescent; Adult; Aged; Antiviral Agents; Double-Blind Method;

1999
Varicella zoster virus infections following allogeneic bone marrow transplantation: frequency, risk factors, and clinical outcome.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2000, Volume: 6, Issue:1

    Topics: 2-Aminopurine; Acyclovir; Adolescent; Adult; Antiviral Agents; Bone Marrow Transplantation; Chickenp

2000
A randomized, double-blind trial of famciclovir versus acyclovir for the treatment of localized dermatomal herpes zoster in immunocompromised patients.
    Cancer investigation, 2001, Volume: 19, Issue:1

    Topics: 2-Aminopurine; Acyclovir; Adolescent; Adult; Aged; Antiviral Agents; Double-Blind Method; Famciclovi

2001

Other Studies

3 other studies available for brl 42810 and Pain

ArticleYear
Intranasal pain in a patient with Behçet's disease.
    BMJ (Clinical research ed.), 2020, Mar-11, Volume: 368

    Topics: Antiviral Agents; Behcet Syndrome; Blister; Endoscopy; Famciclovir; Female; Glucocorticoids; Herpes

2020
One-year follow-up of zoster-associated pain in 764 immunocompetent patients with acute herpes zoster treated with famciclovir (FAMILIAR study).
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2014, Volume: 28, Issue:12

    Topics: 2-Aminopurine; Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Child; Cohort Studies;

2014
Dilemmas in care of the elderly.
    Canadian family physician Medecin de famille canadien, 1997, Volume: 43

    Topics: 2-Aminopurine; Age Factors; Aged; Aged, 80 and over; Antiviral Agents; Costs and Cost Analysis; Famc

1997