Compounds > warangalone
Page last updated: 2024-12-11

warangalone

Description

warangalone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5379679
CHEMBL ID458134
SCHEMBL ID571534
MeSH IDM0274544

Synonyms (24)

Synonym
scandenolone
CHEMBL458134
FT-0655477
scandenone
warangalone
LMPK12050205
5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethyl-10-(3-methylbut-2-enyl)pyrano[3,2-g]chromen-6-one
4449-55-2
A826605
2h,6h-benzo(1,2-b:5,4-b')dipyran-6-one, 5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethyl-10-(3-methyl-2-butenyl)-
AKOS015896248
SCHEMBL571534
2h,6h-benzo[1,2-b:5,4-b']dipyran-6-one, 5-hydroxy-7-(p-hydroxyphenyl)-2,2-dimethyl-10-(3-methyl-2-butenyl)-
2h,6h-benzo[1,2-b:5,4-b']dipyran-6-one, 5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethyl-10-(3-methyl-2-butenyl)-
HGHOPAZIUPORIN-UHFFFAOYSA-N
5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethyl-10-(3-methyl-2-butenyl)-2h,6h-pyrano[3,2-g]chromen-6-one #
warangalon
DTXSID40196193
CS-8196
5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethyl-10-(3-methylbut-2-en-1-yl)-2h,6h-pyrano[3,2-g]chromen-6-one
HY-N1074
MS-26917
XW161525
B0005-418142

Research Excerpts

Overview

Warangalone is a poor inhibitor of avian calmodulin-dependent myosin light chain kinase (MLCK), rat brain Ca(2+)- and phospholipid-dependent protein kinase C (PKC) and wheat embryo CDPK.

ExcerptReferenceRelevance
"Warangalone is a poor inhibitor of avian calmodulin-dependent myosin light chain kinase (MLCK), rat brain Ca(2+)- and phospholipid-dependent protein kinase C (PKC) and wheat embryo Ca(2+)-dependent protein kinase (CDPK)."( Specific inhibition of cyclic AMP-dependent protein kinase by warangalone and robustic acid.
Polya, G; Ternai, B; Wang, BH, 1997)		1.26

Treatment

ExcerptReferenceRelevance
"Treatment with warangalone significantly inhibited migration of the breast cancer cells and down-regulated the cellular expressions of MMP2 and MMP9."( [Preparation of warangalone-loaded liposomes and its inhibitory effect on breast cancer cells].
Bian, Z; Liao, W; Liu, H; Mao, L; Sun, S; Zhang, Q, 2020)		1.24
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (53)

Assay IDTitleYearJournalArticle
AID356051Inhibition of PKC catalytic subunit2003Journal of natural products, Jun, Volume: 66, Issue:6
Warangalone, the isoflavonoid anti-inflammatory principle of Erythrina addisoniae stem bark.
AID1081925Insecticidal activity against 3 to 8 days old Rhyzopertha dominica assessed as mortality measured after 24 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1104297Antifeedant activity against Achaea janata by conventional no-choice disk method2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1104292Toxicity against Achaea janata at 10 ug/cm2 after 24 hr by leaf disk method2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1385660Antibacterial activity against Salmonella typhimurium TISTR 781 by 2-fold serial dilution method2018Journal of natural products, 08-24, Volume: 81, Issue:8
Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa.
AID1081922Insecticidal activity against 3 to 8 days old Tribolium castaneum (red flour beetle) assessed as mortality at 1 ug/mL measured after 72 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1081934Insecticidal activity against 3 to 8 days old Callosobruchus chinensis assessed as mortality at 1 ug/mL measured after 72 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1104294Toxicity against Achaea janata after 24 hr by leaf disk method2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1385659Antibacterial activity against Staphylococcus epidermidis ATCC 12228 by 2-fold serial dilution method2018Journal of natural products, 08-24, Volume: 81, Issue:8
Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa.
AID1081926Insecticidal activity against 3 to 8 days old Rhyzopertha dominica assessed as mortality at 1 ug/mL measured after 72 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1104288Insecticidal activity against Achaea janata assessed as larval mortality at 4 ug/larva administered through topical application2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1081924Insecticidal activity against 3 to 8 days old Tribolium castaneum (red flour beetle) assessed as mortality at 1 ug/mL measured after 24 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID356046Antiinflammatory activity against TPA-induced ear edema in Swiss mouse chronic dermatitis model assessed as inhibition of increase in ear weight2003Journal of natural products, Jun, Volume: 66, Issue:6
Warangalone, the isoflavonoid anti-inflammatory principle of Erythrina addisoniae stem bark.
AID1104280Insecticidal activity against Achaea janata assessed as adult deformity at 4 ug/larva administered through topical application2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1081930Insecticidal activity against 3 to 8 days old Sitophilus oryzae (rice weevil) assessed as mortality at 1 ug/mL measured after 72 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1081928Insecticidal activity against 3 to 8 days old Rhyzopertha dominica assessed as mortality at 1 ug/mL measured after 24 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1104277Insecticidal activity against Achaea janata assessed as adult emergence at 2 ug/larva administered through topical application (Rvb = 98.8 +/- 0.5 %)2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID356059Antiinflammatory activity against Swiss mouse chronic dermatitis model assessed as inhibition of TPA-induced tissue myeloperoxidase activity at 0.25 mg/ear applied twice daily for 4 days measured after 6 hrs relative to control2003Journal of natural products, Jun, Volume: 66, Issue:6
Warangalone, the isoflavonoid anti-inflammatory principle of Erythrina addisoniae stem bark.
AID1104283Insecticidal activity against Achaea janata assessed as pupal weight at 2 ug/larva administered through topical application (Rvb = 696.4 +/- 2.6 mg)2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1104285Insecticidal activity against Achaea janata assessed as pupal duration at 2 ug/larva administered through topical application (Rvb = 10.3 +/- 0.1 days)2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1104290Insecticidal activity against Achaea janata assessed as larval duration at 4 ug/larva administered through topical application (Rvb = 7.3 +/- 0.1 days)2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1081923Insecticidal activity against 3 to 8 days old Tribolium castaneum (red flour beetle) assessed as mortality at 1 ug/mL measured after 48/ hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1104295Antifeedant activity against Achaea janata at 1 ug/cm2 by conventional no-choice disk method2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1385661Antibacterial activity against Pseudomonas aeruginosa TISTR 292 by 2-fold serial dilution method2018Journal of natural products, 08-24, Volume: 81, Issue:8
Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa.
AID356047Effect on elastase release in rat polymorphonuclear leukocytes2003Journal of natural products, Jun, Volume: 66, Issue:6
Warangalone, the isoflavonoid anti-inflammatory principle of Erythrina addisoniae stem bark.
AID1104289Insecticidal activity against Achaea janata assessed as larval mortality at 2 ug/larva administered through topical application2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1545123Toxicity in mouse RAW264.7 cells assessed as cell viability at 10 uM by MTT assay2019Journal of natural products, 08-23, Volume: 82, Issue:8
Antibacterial and Inhibitory Activities against Nitric Oxide Production of Coumaronochromones and Prenylated Isoflavones from
AID1081931Insecticidal activity against 3 to 8 days old Sitophilus oryzae (rice weevil) assessed as mortality at 1 ug/mL measured after 48 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1081927Insecticidal activity against 3 to 8 days old Rhyzopertha dominica assessed as mortality at 1 ug/mL measured after 48 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID356052Antiinflammatory activity against Naja mossambica PLA2-induced Swiss mouse paw edema assessed as inhibition of paw volume at 5 mg/kg, ip administered before 30 mins of PLA2 challenge measured after 30 mins relative to control2003Journal of natural products, Jun, Volume: 66, Issue:6
Warangalone, the isoflavonoid anti-inflammatory principle of Erythrina addisoniae stem bark.
AID1545122Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay2019Journal of natural products, 08-23, Volume: 82, Issue:8
Antibacterial and Inhibitory Activities against Nitric Oxide Production of Coumaronochromones and Prenylated Isoflavones from
AID1104299Antifeedant activity against Achaea janata at 10 ug/cm2 by conventional no-choice disk method2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1081932Insecticidal activity against 3 to 8 days old Sitophilus oryzae (rice weevil) assessed as mortality at 1 ug/mL measured after 24 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID356049Inhibition of calcium ionophore A-23187/calcium-stimulated 12-hydroxyheptadecatrienoic acid production in human platelets2003Journal of natural products, Jun, Volume: 66, Issue:6
Warangalone, the isoflavonoid anti-inflammatory principle of Erythrina addisoniae stem bark.
AID1104286Insecticidal activity against Achaea janata assessed as pupal duration at 4 ug/larva administered through topical application (Rvb = 10.3 +/- 0.1 days)2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1104278Insecticidal activity against Achaea janata assessed as adult emergence at 4 ug/larva administered through topical application (Rvb = 98.8 +/- 0.5 %)2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID356048Inhibition of calcium ionophore A-23187/calcium-stimulated LTB4 production in rat polymorphonuclear leukocytes2003Journal of natural products, Jun, Volume: 66, Issue:6
Warangalone, the isoflavonoid anti-inflammatory principle of Erythrina addisoniae stem bark.
AID1081921Insecticidal activity against 3 to 8 days old Tribolium castaneum (red flour beetle) assessed as mortality measured after 24 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1104284Insecticidal activity against Achaea janata assessed as pupal weight at 4 ug/larva administered through topical application (Rvb = 696.4 +/- 2.6 mg)2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID356053Antiinflammatory activity against Naja mossambica PLA2-induced Swiss mouse paw edema assessed as inhibition of paw volume at 5 mg/kg, ip administered before 30 mins of PLA2 challenge measured after 60 mins relative to control2003Journal of natural products, Jun, Volume: 66, Issue:6
Warangalone, the isoflavonoid anti-inflammatory principle of Erythrina addisoniae stem bark.
AID1104291Insecticidal activity against Achaea janata assessed as larval duration at 2 ug/larva administered through topical application (Rvb = 7.3 +/- 0.1 days)2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1081935Insecticidal activity against 3 to 8 days old Callosobruchus chinensis assessed as mortality at 1 ug/mL measured after 48 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1104282Insecticidal activity against Achaea janata assessed as pupal mortality at 4 ug/larva administered through topical application2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID356050Antioxidant activity assessed as DPPH free radical scavenging activity2003Journal of natural products, Jun, Volume: 66, Issue:6
Warangalone, the isoflavonoid anti-inflammatory principle of Erythrina addisoniae stem bark.
AID1104281Insecticidal activity against Achaea janata assessed as pupal mortality at 2 ug/larva administered through topical application2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1081929Insecticidal activity against 3 to 8 days old Sitophilus oryzae (rice weevil) assessed as mortality measured after 72 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID356057Antiinflammatory activity against TPA-induced ear edema in Swiss mouse chronic dermatitis model assessed as inhibition of increase in ear weight at 0.25 mg/ear relative to control2003Journal of natural products, Jun, Volume: 66, Issue:6
Warangalone, the isoflavonoid anti-inflammatory principle of Erythrina addisoniae stem bark.
AID1385657Antibacterial activity against Bacillus subtilis TISTR 008 by 2-fold serial dilution method2018Journal of natural products, 08-24, Volume: 81, Issue:8
Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa.
AID1081933Insecticidal activity against 3 to 8 days old Callosobruchus chinensis assessed as mortality measured after 72 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1081936Insecticidal activity against 3 to 8 days old Callosobruchus chinensis assessed as mortality at 1 ug/mL measured after 24 hr by fumigation assay2011Journal of agricultural and food chemistry, Mar-09, Volume: 59, Issue:5
Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
AID1385658Antibacterial activity against Staphylococcus aureus TISTR 1466 by 2-fold serial dilution method2018Journal of natural products, 08-24, Volume: 81, Issue:8
Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa.
AID1104279Insecticidal activity against Achaea janata assessed as adult deformity at 2 ug/larva administered through topical application2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
AID1104296Antifeedant activity against Achaea janata at 2 ug/cm2 by conventional no-choice disk method2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's2 (20.00)29.6817
2010's5 (50.00)24.3611
2020's2 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.57

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.57 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.96 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.57)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
adenine
[no description available]		2.31106-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.3110aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
cyproheptadine
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.. cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.		2.0110piperidines;
tertiary amine		anti-allergic agent;
antipruritic drug;
gastrointestinal drug;
H1-receptor antagonist;
serotonergic antagonist
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		2.4720aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
pomiferin
pomiferin: structure in first source		2.1510isoflavanones
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		2.5920glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
gentamicin c1
[no description available]		2.1710
gentamicin c1a
[no description available]		2.2110gentamycin C
inermin
inermin: phytoalexin produced in plants after injection with fungi; RN given refers to (cis-(+-))-isomer; RN for cpd without isomeric designation; structure. (-)-maackiain : The (-)-enantiomer of maackiain.		2.1710maackiain
osajin
osajin: from Maclura pomifera		2.7730isoflavanones
leukotriene b4
Leukotriene B4: The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990). leukotriene B4 : A leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. It is a lipid mediator of inflammation that is generated from arachidonic acid via the 5-lipoxygenase pathway.		2.0110dihydroxy monocarboxylic acid;
hydroxy polyunsaturated fatty acid;
leukotriene;
long-chain fatty acid		human metabolite;
mouse metabolite;
plant metabolite;
vasoconstrictor agent
genistein
[no description available]		2.46207-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
auriculasin
auriculasin: isolated from the fruits of Maclura pomifera; structure in first source		2.7830isoflavanones
lupalbigenin
lupalbigenin: has antineoplastic activity; isolated from Derris scandens; structure in first source		2.4620isoflavanones
4-hydroxy-3-(4-hydroxyphenyl)-5-methoxy-8,8-dimethyl-6-(3-methylbut-2-enyl)-2-pyrano[2,3-h][1]benzopyranone
[no description available]		2.4620isoflavonoid
robustic acid
robustic acid: structure in first source		6.9910isoflavonoid;
organic hydroxy compound
3-methyladenine
N3-methyladenine: structure in first source		2.3110
ConditionIndicatedRelationship StrengthStudiesTrials
Anasarca
[description not available]		02.4220
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		02.4220
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.0310
Ache
[description not available]		02.0310
Gastric Ulcer
[description not available]		02.0310
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.		02.0310
Stomach Ulcer
Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).		02.0310
Breast Cancer
[description not available]		02.6920
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.6920
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