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1-aminoindan-1,5-dicarboxylic acid and Pain

1-aminoindan-1,5-dicarboxylic acid has been researched along with Pain in 5 studies

1-aminoindan-1,5-dicarboxylic acid: structure given in first source

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"The effect of the non-selective, 1-aminoindan-1,5-dicarboxylic acid (AIDA), and selective (3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl) methanone (JNJ16259685), metabotropic glutamate subtype 1 (mGlu1) receptor antagonists, on rat sciatic nerve chronic constrictive injury (CCI)-induced hyperalgesia, allodynia, spinal dorsal horn apoptosis, and gliosis was examined at 3 and 7 days post-injury."3.74Involvement of subtype 1 metabotropic glutamate receptors in apoptosis and caspase-7 over-expression in spinal cord of neuropathic rats. ( de Novellis, V; Ferraraccio, F; Fuccio, C; Giordano, C; Luongo, L; Maione, S; Rossi, F; Roth, KA; Siniscalco, D, 2008)
"Intraspinal injection of quisqualic acid, a mixed kainic acid/2-amino-3(3-hydroxy-5-methylisoxazol-4-yl)propionic acid and metabotropic glutamate receptor agonist, produces an excitotoxic injury that leads to the onset of both spontaneous and evoked pain behavior as well as changes in spinal and cortical expression of opioid peptide mRNA, preprodynorphin and preproenkephalin."3.71The role of kainic acid/AMPA and metabotropic glutamate receptors in the regulation of opioid mRNA expression and the onset of pain-related behavior following excitotoxic spinal cord injury. ( Abraham, KE; Brewer, KL; McGinty, JF, 2001)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fisher, K1
Lefebvre, C1
Coderre, TJ1
Siniscalco, D1
Giordano, C1
Fuccio, C1
Luongo, L1
Ferraraccio, F1
Rossi, F1
de Novellis, V1
Roth, KA1
Maione, S1
Bordi, F1
Ugolini, A1
Abraham, KE1
McGinty, JF1
Brewer, KL1
Zhou, S1
Komak, S1
Du, J1
Carlton, SM1

Other Studies

5 other studies available for 1-aminoindan-1,5-dicarboxylic acid and Pain

ArticleYear
Antinociceptive effects following intrathecal pretreatment with selective metabotropic glutamate receptor compounds in a rat model of neuropathic pain.
    Pharmacology, biochemistry, and behavior, 2002, Volume: 73, Issue:2

    Topics: Analgesics; Animals; Constriction, Pathologic; Excitatory Amino Acid Antagonists; Indans; Injections

2002
Involvement of subtype 1 metabotropic glutamate receptors in apoptosis and caspase-7 over-expression in spinal cord of neuropathic rats.
    Pharmacological research, 2008, Volume: 57, Issue:3

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Behavior, Animal; Caspase 7; Constriction, Pathol

2008
Involvement of mGluR(5) on acute nociceptive transmission.
    Brain research, 2000, Jul-21, Volume: 871, Issue:2

    Topics: Animals; Electric Stimulation; Excitatory Amino Acid Antagonists; In Vitro Techniques; Indans; Injec

2000
The role of kainic acid/AMPA and metabotropic glutamate receptors in the regulation of opioid mRNA expression and the onset of pain-related behavior following excitotoxic spinal cord injury.
    Neuroscience, 2001, Volume: 104, Issue:3

    Topics: Animals; Behavior, Animal; Dynorphins; Enkephalins; Excitatory Amino Acid Agonists; Excitatory Amino

2001
Metabotropic glutamate 1alpha receptors on peripheral primary afferent fibers: their role in nociception.
    Brain research, 2001, Sep-14, Volume: 913, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excita

2001