Page last updated: 2024-08-02 20:29:19

ly2183240

Description

LY2183240: structure in first source [MeSH]

N,N-dimethyl-5-[(4-phenylphenyl)methyl]-1-tetrazolecarboxamide : no description available [CHeBI]

Cross-References

ID Source	ID
PubMed CID	11507802
CHEMBL ID	509860
SCHEMBL ID	2184828
CHEBI ID	92670
MeSH ID	M0513545

Synonyms (42)

Synonym
n,n-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide
HY-10865
HMS3269E15
NCGC00159571-01
chembl509860 ,
bdbm26736
ly2183240
n,n-dimethyl-5-[(4-phenylphenyl)methyl]-1h-1,2,3,4-tetrazole-1-carboxamide
ly-2183240
874902-19-9
BCP9000870
ly2183240/ly-2183240
BCP0726000083
5-biphenyl-4-ylmethyl-tetrazole-1-carboxylic acid dimethylamide
LP01268
CS-0913
BRD-K37865504-001-01-7
5-([1,1'-biphenyl]-4-ylmethyl)-n,n-dimethyl-1h-tetrazole-1-carboxamide
SCHEMBL2184828
5-[(1,1'-biphenyl]-4-yl)methyl]-n,n-dimethyl-1h-tetrazole-1-carboxamide
ly 2183240
AKOS024457108
CHEBI:92670
2WBU91OKM7 ,
5-(biphenyl-4-ylmethyl)-n,n-dimethyl-1h-tetrazole-1-carboxamide
1h-tetrazole-1-carboxamide, 5-((1,1'-biphenyl)-4-ylmethyl)-n,n-dimethyl-
ly-2183240; ly 2183240
BCP22610
unii-2wbu91okm7
HMS3677O06
HMS3413O06
n,n-dimethyl-5-[(4-phenylphenyl)methyl]-1-tetrazolecarboxamide
Q6460409
SDCCGSBI-0633820.P001
F84861
EX-A4760
S8052
DTXSID001024706
5-((1,1'-biphenyl)-4-ylmethyl)-n,n-dimethyl-1h-tetrazole-1-carboxamide
AS-82203
AC-36729
5-[[(1,1'-biphenyl)-4-yl]methyl]-n,n-dimethyl-1h-tetrazole-1-carboxamide

Drug Classes (1)

Class	Description
biphenyls	Benzenoid aromatic compounds containing two phenyl or substituted-phenyl groups which are joined together by a single bond.

Protein Targets (11)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	1.0000	AID1030

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)
Fatty-acid amide hydrolase 1	Homo sapiens (human)	IC50	0.0248	AID439742; AID441698; AID612783; AID726796
Fatty-acid amide hydrolase 1	Mus musculus (house mouse)	IC50	0.0130	AID1798722
Monoglyceride lipase	Mus musculus (house mouse)	IC50	0.0045	AID1798723
Fatty-acid amide hydrolase 1	Rattus norvegicus (Norway rat)	IC50	0.0099	AID346665; AID612777; AID743631
Fatty-acid amide hydrolase 1	Rattus norvegicus (Norway rat)	Ki	0.0120	AID412539
Transient receptor potential cation channel subfamily A member 1	Rattus norvegicus (Norway rat)	IC50	49.4000	AID743747
Neutral cholesterol ester hydrolase 1	Mus musculus (house mouse)	IC50	0.0045	AID1798723
Transient receptor potential cation channel subfamily V member 1	Homo sapiens (human)	IC50	100.0000	AID743741
Monoacylglycerol lipase ABHD6	Mus musculus (house mouse)	IC50	0.0045	AID1798723
Monoglyceride lipase	Homo sapiens (human)	IC50	0.1331	AID439741; AID441697; AID743632
Diacylglycerol lipase-alpha	Homo sapiens (human)	IC50	10.0000	AID382401

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)
Transient receptor potential cation channel subfamily A member 1	Rattus norvegicus (Norway rat)	EC50	26.9000	AID743739

Bioassays (34)

Assay ID	Title	Year	Journal	Article
AID441792	Selectivity ratio for human MGL activity to human recombinant FAAH	2009	Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22 ISSN: 1520-4804	Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors.
AID743740	Agonist activity at rat TRPA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by spectrofluorimetric analysis relative to allyl isothiocyanate	2013	European journal of medicinal chemistry, May, Volume: 63ISSN: 1768-3254	Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring.
AID612783	Inhibition of FAAH	2011	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 ISSN: 1464-3405	The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).
AID382405	Inhibition of [14C]anandamide uptake in rat RBL-2H3 cells preincubated 10 mins before addition of [14C]anandamide	2008	European journal of medicinal chemistry, Jan, Volume: 43, Issue:1 ISSN: 0223-5234	Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation.
AID743632	Inhibition of human recombinant MAGL-mediated 1,3-dihydroxypropan-1-yl 4-pyren-1-ylbutanoate conversion to 4-pyren-1-ylbutanoic acid preincubated for 15 mins measured after 45 mins by HPLC analysis	2013	European journal of medicinal chemistry, May, Volume: 63ISSN: 1768-3254	(4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).
AID612777	Inhibition of rat FAAH	2011	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 ISSN: 1464-3405	The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).
AID382407	Inhibition of [14C]anandamide uptake in rat RBL-2H3 cells at 1 uM preincubated 10 mins before addition of [14C]anandamide	2008	European journal of medicinal chemistry, Jan, Volume: 43, Issue:1 ISSN: 0223-5234	Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation.
AID346665	Inhibition of rat FAAH	2008	Journal of medicinal chemistry, Dec-11, Volume: 51, Issue:23 ISSN: 1520-4804	Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors.
AID382404	Inhibition of FAAH mediated [14C]anandamide hydrolysis in rat brain at 1 uM after 30 mins	2008	European journal of medicinal chemistry, Jan, Volume: 43, Issue:1 ISSN: 0223-5234	Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation.
AID743628	Selectivity ratio of IC50 for human recombinant MAGL to IC50 for FAAH in Sprague-Dawley rat brain microsomes	2013	European journal of medicinal chemistry, May, Volume: 63ISSN: 1768-3254	(4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).
AID441698	Inhibition of human recombinant FAAH-maltose binding protein	2009	Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22 ISSN: 1520-4804	Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors.
AID439742	Inhibition of human FAAH	2009	Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 ISSN: 1520-4804	Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors.
AID743626	Inhibition of cytosolic phospholipase A2alpha in porcine platelets assessed as 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine conversion to arachidonic acid at 10 uM by HPLC analysis	2013	European journal of medicinal chemistry, May, Volume: 63ISSN: 1768-3254	(4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).
AID743631	Inhibition of FAAH in Sprague-Dawley rat brain microsomes assessed as N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide conversion to 4-pyren-1-ylbutanoic acid preincubated for 10 mins measured after 45 mins by HPLC analysis	2013	European journal of medicinal chemistry, May, Volume: 63ISSN: 1768-3254	(4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).
AID743747	Antagonist activity at rat TRPA1 receptor expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced intracellular Ca2+ elevation incubated for 5 mins prior to allyl isothiocyanate-stimulation by spectrofluorimetric analysis	2013	European journal of medicinal chemistry, May, Volume: 63ISSN: 1768-3254	Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring.
AID441697	Inhibition of human MGL activity using [3H]2-oleoylglycerol substrate by liquid scintillation counting	2009	Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22 ISSN: 1520-4804	Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors.
AID382403	Inhibition of FAAH mediated [14C]anandamide hydrolysis in rat brain at 0.1 uM after 30 mins	2008	European journal of medicinal chemistry, Jan, Volume: 43, Issue:1 ISSN: 0223-5234	Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation.
AID743742	Agonist activity at human TRPV1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by spectrofluorimetric analysis	2013	European journal of medicinal chemistry, May, Volume: 63ISSN: 1768-3254	Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring.
AID726796	Inhibition of FAAH (unknown origin)	2013	Bioorganic & medicinal chemistry, Jan-01, Volume: 21, Issue:1 ISSN: 1464-3391	Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.
AID382400	Inhibition of MAGL mediated [14C]2-arachidonoyl glycerol hydrolysis in african green monkey COS cells	2008	European journal of medicinal chemistry, Jan, Volume: 43, Issue:1 ISSN: 0223-5234	Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation.
AID743739	Agonist activity at rat TRPA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by spectrofluorimetric analysis	2013	European journal of medicinal chemistry, May, Volume: 63ISSN: 1768-3254	Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring.
AID382406	Inhibition of [14C]anandamide uptake in rat RBL-2H3 cells at 0.1 uM preincubated 10 mins before addition of [14C]anandamide	2008	European journal of medicinal chemistry, Jan, Volume: 43, Issue:1 ISSN: 0223-5234	Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation.
AID439743	Selectivity ratio of IC50 for human FAAH to IC50 for human MGL	2009	Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 ISSN: 1520-4804	Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors.
AID1363883	Inhibition of mouse brain membrane FAAH preincubated for 10 mins followed by 14C-oleamide substrate addition measured up to 60 mins by TLC analysis	2017	Journal of medicinal chemistry, 01-12, Volume: 60, Issue:1 ISSN: 1520-4804	Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors.
AID382402	Inhibition of FAAH mediated [14C]anandamide hydrolysis in rat brain after 30 mins	2008	European journal of medicinal chemistry, Jan, Volume: 43, Issue:1 ISSN: 0223-5234	Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation.
AID382401	Inhibition of human recombinant DAGLalpha mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in COS cells after 20 mins	2008	European journal of medicinal chemistry, Jan, Volume: 43, Issue:1 ISSN: 0223-5234	Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation.
AID743743	Agonist activity at human TRPV1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by spectrofluorimetric analysis relative to ionomycin	2013	European journal of medicinal chemistry, May, Volume: 63ISSN: 1768-3254	Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring.
AID439741	Inhibition of human MGL	2009	Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 ISSN: 1520-4804	Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors.
AID743741	Antagonist activity at human TRPV1 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ elevation incubated for 5 mins prior to capsaicin-stimulation by spectrofluorimetric analysis	2013	European journal of medicinal chemistry, May, Volume: 63ISSN: 1768-3254	Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring.
AID412539	Inhibition of rat cortex FAAH by [3H]anandamide carbon filtration assay	2009	Journal of medicinal chemistry, Jan-08, Volume: 52, Issue:1 ISSN: 1520-4804	Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors.
AID1508630	Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay	2021	Cell reports, 04-27, Volume: 35, Issue:4 ISSN: 2211-1247	A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347154	Primary screen GU AMC qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1798723	Serine Hydrolase Activity Assay from Article 10.1021/ja062999h: \\The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases.\\	2006	Journal of the American Chemical Society, Aug-02, Volume: 128, Issue:30 ISSN: 0002-7863	The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases.
AID1798722	FAAH Competitive ABPP Using FP-Rhodamine from Article 10.1021/ja062999h: \\The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases.\\	2006	Journal of the American Chemical Society, Aug-02, Volume: 128, Issue:30 ISSN: 0002-7863	The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases.

Research

Studies (18)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (33.33)	29.6817
2010's	9 (50.00)	24.3611
2020's	3 (16.67)	2.80

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	3 (16.67%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (83.33%)	84.16%

Substance	Classes	Roles	Relationship Strength
bay h 4502	biphenyls; imidazoles		low
candesartan cilexetil	biphenyls		low
4-biphenylylacetic acid	biphenyls; monocarboxylic acid	non-steroidal anti-inflammatory drug	low
fenbufen	4-oxo monocarboxylic acid; biphenyls	non-steroidal anti-inflammatory drug	low
3,3'-dichlorobenzidine	biphenyls; monochlorobenzenes; organochlorine compound		low
3,3'-diaminobenzidine	biphenyls; substituted aniline	histological dye	low
diphenyl	aromatic fungicide; benzenes; biphenyls	antifungal agrochemical; antimicrobial food preservative	low
benzidine	biphenyls; substituted aniline	carcinogenic agent	low
4-nitrobiphenyl	biphenyls		low
dianisidine	biphenyls		low
2-tolidine	biphenyls		low
n,n'-diacetylbenzidine	biphenyls		low
2-amino-4-phenylphenol	biphenyls		low
4-acetylaminobiphenyl	biphenyls		low
4-biphenylylacetic acid ethyl ester	biphenyls		low
brequinar	biphenyls; monocarboxylic acid; monofluorobenzenes; quinolinemonocarboxylic acid	anticoronaviral agent; antimetabolite; antineoplastic agent; antiviral agent; EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor; immunosuppressive agent; pyrimidine synthesis inhibitor	low
tasosartan	biphenyls		low
telmisartan	benzimidazoles; biphenyls; carboxybiphenyl	angiotensin receptor antagonist; antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; environmental contaminant; xenobiotic	low
clobuzarit	biphenyls; organochlorine compound		low
magnolol	biphenyls		low
honokiol	biphenyls		low
bitertanol	aromatic ether; biphenyls; secondary alcohol; triazoles		low
isodiospyrin	biphenyls		low
difenpiramide	biphenyls; monocarboxylic acid amide; pyridines	antipyretic; non-narcotic analgesic; non-steroidal anti-inflammatory drug	low
2-(4-phenylphenoxy)propanoic acid	biphenyls		low
4-hydroxy-2',4',6'-trichlorobiphenyl	biphenyls; trichlorobenzene		low
4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl	biphenyls; tetrachlorobenzene		low
dityrosine	biphenyls; non-proteinogenic alpha-amino acid; tyrosine derivative	biomarker	low
4,4'-bis(methylsulfonyl)-2,2',5,5'-tetrachlorobiphenyl	biphenyls; dichlorobenzene; sulfone		low
nitroflurbiprofen	biphenyls; carboxylic ester; nitrate ester; organofluorine compound	cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; EC 1.14.13.39 (nitric oxide synthase) inhibitor; geroprotector; non-steroidal anti-inflammatory drug; vasodilator agent	low
olmesartan medoxomil	biphenyls		low
4'-hydroxyflurbiprofen	biphenyls		low
dehydrodieugenol	biphenyls		low
bifeprunox	biphenyls		low
2-chloro-n-(4-chlorobiphenyl-2-yl)nicotinamide	anilide fungicide; biphenyls; monochlorobenzenes; pyridinecarboxamide	antifungal agrochemical; EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor; environmental contaminant; xenobiotic	low
aucuparin	biphenyls		low
2-[(3,4-dimethoxyphenyl)methyl]-5-[4-(4-methoxyphenyl)phenyl]-1,3,4-oxadiazole	biphenyls		low
2-(2,5-dimethoxyphenyl)-5-[4-(4-methoxyphenyl)phenyl]-1,3,4-oxadiazole	biphenyls		low
(2'-(benzyloxycarbonylaminomethyl)biphenyl-2-carboxylic acid 2-(2-pyridyl)ethylamide)	biphenyls		low
4-phenylbenzoic acid (propan-2-ylideneamino) ester	biphenyls		low
N-[[(6-methyl-2-pyridinyl)amino]-sulfanylidenemethyl]-4-phenylbenzamide	biphenyls		low
4-phenyl-N-(2-propyl-5-tetrazolyl)benzamide	biphenyls		low
2-[(1-methyl-5-tetrazolyl)thio]-N-(2-phenylphenyl)acetamide	biphenyls		low
3-phenyl-5-(2-phenylphenyl)-1,2,4-oxadiazole	biphenyls		low
N-[[methyl-(phenylmethyl)amino]-sulfanylidenemethyl]-4-phenylbenzamide	biphenyls		low
N-[4-[4-(ethylsulfonylamino)-3-methoxyphenyl]-2-methoxyphenyl]ethanesulfonamide	biphenyls		low
urb 597	biphenyls		low
3-(4-phenylphenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepine	biphenyls		low
ac 55649	biphenyls; carboxybiphenyl		low
1-[3-(4-phenylphenoxy)propyl]-1,2,4-triazole	biphenyls		low
N-[2-(2-phenylphenoxy)ethyl]-2-furancarboxamide	biphenyls		low
2-(2-phenylanilino)-N-(phenylmethyl)acetamide	biphenyls		low
4-(2-fluorophenyl)-N-(2-methylbut-3-yn-2-yl)benzamide	biphenyls		low
5-oxo-3-(4-phenylphenyl)-2H-furan-4-carbonitrile	biphenyls		low
N-([biphenyl]-2-yl)-3-cyclopentylpropanamide	biphenyls; cyclopentanes; secondary carboxamide		low
1-(4-morpholinyl)-2-(4-phenylphenoxy)-1-propanone	biphenyls		low
2-(4-morpholinyl)-N-(2-phenylphenyl)propanamide	biphenyls		low
4-[4-[2-hydroxy-3-(4-morpholinyl)propoxy]phenyl]benzonitrile	biphenyls; nitrile		low
3-[4-[(2-hydroxy-5-phenylphenyl)methyl]-1-piperazinyl]propanenitrile	biphenyls		low
N-(2-methoxyethyl)-4-[4-(2-methoxyethylsulfamoyl)phenyl]benzenesulfonamide	biphenyls		low
2-phenylbutanoic acid [2-oxo-2-(2-phenylanilino)ethyl] ester	biphenyls		low
2-(4-benzoyl-1-piperazinyl)-N-(2-phenylphenyl)propanamide	biphenyls		low
fexaramine	biphenyls		low
alx 5407	biphenyls		low
bay 12-9566	biphenyls; organochlorine compound		low
sacubitril	biphenyls		low
biphenyl-indanone a	biphenyls		low
fimasartan	biphenyls		low
2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoic acid	biphenyls; organobromine compound		low
l-161982	biphenyls		low
N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide	1,3,4-oxadiazoles; benzamides; biphenyls; nitrile	EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	low
abt-737	aromatic amine; aryl sulfide; biphenyls; C-nitro compound; monochlorobenzenes; N-arylpiperazine; N-sulfonylcarboxamide; secondary amino compound; tertiary amino compound	anti-allergic agent; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; B-cell lymphoma 2 inhibitor	low
4-[4-(2-fluorophenyl)phenyl]-N-(4-hydroxyphenyl)butanamide	biphenyls		low
fluxapyroxad	anilide fungicide; aromatic amide; biphenyls; pyrazoles; trifluorobenzene	antifungal agrochemical; EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor	low
(3R,3aS,7R,7aS)-3-[4-[4-(dimethylamino)phenyl]-2-fluorophenyl]-7-methyl-2-(phenylmethyl)-3a,6,7,7a-tetrahydro-3H-isoindol-1-one	biphenyls		low
3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide	biphenyls		low
WWL113	biphenyls		low
lde225	aminopyridine; aromatic ether; benzamides; biphenyls; morpholines; organofluorine compound; tertiary amino compound	antineoplastic agent; Hedgehog signaling pathway inhibitor; SMO receptor antagonist	low
N-[3-(3-chlorophenyl)phenyl]-1-(3-isoxazolylmethyl)-4-piperidinecarboxamide	biphenyls; organochlorine compound		low
N-[3-(3-chlorophenyl)phenyl]-1-(3-oxolanylmethyl)-4-piperidinecarboxamide	biphenyls; organochlorine compound		low
4-(4-acetyloxyphenyl)benzoic acid [2-[[2-(2-chloroanilino)-2-oxoethyl]-methylamino]-2-oxoethyl] ester	biphenyls		low
N-cyclopropyl-3-{4-[(cyclopropylmethyl)carbamoyl]phenyl}-4-methylbenzamide	benzamides; biphenyls; cyclopropanes; dicarboxylic acid diamide	EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	low
tak-875	biphenyls		low
bms-790052	biphenyls; carbamate ester; carboxamide; imidazoles; valine derivative	antiviral drug; nonstructural protein 5A inhibitor	low
(2S)-2-[[2-(2,3-dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]-6-purinyl]amino]-3-phenyl-1-propanol	biphenyls		low
4-[(1-methyl-5-tetrazolyl)thio]-5-(4-phenylphenyl)thieno[2,3-d]pyrimidine	biphenyls; thienopyrimidine		low
ml228 probe	1,2,4-triazines; biphenyls; pyridines; secondary amino compound	hypoxia-inducible factor pathway activator	low
a 769662	biphenyls		low

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	2000's	2010's
disulfiram	2	organic disulfide; organosulfur acaricide	angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor; EC 3.1.1.1 (carboxylesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 5.99.1.2 (DNA topoisomerase) inhibitor; ferroptosis inducer; fungicide; NF-kappaB inhibitor	2009	2017	11.0	low	1	1
hexadecanesulfonyl fluoride	1	acyl fluoride		2017	2017	7.0	low	0	1
ethylmaleimide	2	maleimides	anticoronaviral agent; EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor; EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor; EC 2.7.1.1 (hexokinase) inhibitor	2009	2017	11.0	low	1	1
phenylmethylsulfonyl fluoride	1	acyl fluoride	serine proteinase inhibitor	2008	2008	16.0	low	1	0
propofol	1	phenols	anticonvulsant; antiemetic; intravenous anaesthetic; radical scavenger; sedative	2008	2008	16.0	low	1	0
thiram	1	organic disulfide	antibacterial drug; antifungal agrochemical; antiseptic drug	2009	2009	15.0	low	1	0
carbaryl	2	carbamate ester; naphthalenes	acaricide; agrochemical; carbamate insecticide; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; plant growth retardant	2008	2011	14.5	low	1	1
bis(1-piperidylthiocarbonyl)disulfide	1			2009	2009	15.0	low	1	0
tetramethylthiuram monosulfide	1			2009	2009	15.0	low	1	0
4,4'-dithiodimorpholine	1			2009	2009	15.0	medium	1	0
methyl diethyldithiocarbamate	1			2009	2009	15.0	low	1	0
diphenyl disulfide	1	benzenes		2017	2017	7.0	low	0	1
n-phenylmaleimide	1			2009	2009	15.0	low	1	0
1,6-bismaleimidohexane	1			2009	2009	15.0	low	1	0
diacerein	1	anthraquinone		2017	2017	7.0	low	0	1
2-n-octyl-4-isothiazolin-3-one	1	1,2-thiazoles	antibacterial agent; antifungal agrochemical; environmental contaminant; xenobiotic	2017	2017	7.0	low	0	1
n-phenylphthalimide	1			2009	2009	15.0	low	1	0
n-methylmaleimide	1			2009	2009	15.0	low	1	0
n-benzylmaleimide	1			2009	2009	15.0	low	1	0
n,n'-4-phenylenedimaleimide	1			2009	2009	15.0	low	1	0
n-(2-methoxyphenyl)maleimide	1			2009	2009	15.0	high	1	0
n-(4-bromophenyl)maleimide	1			2009	2009	15.0	high	1	0
arachidonic acid	1	icosa-5,8,11,14-tetraenoic acid; long-chain fatty acid; omega-6 fatty acid	Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite; mouse metabolite	2008	2008	16.0	low	1	0
oleic acid	1	octadec-9-enoic acid	antioxidant; Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; Escherichia coli metabolite; mouse metabolite; plant metabolite; solvent	2008	2008	16.0	low	1	0
urb 597	7	biphenyls		2008	2017	12.0	low	2	5
jnj-1661010	2	N-arylpiperazine		2011	2013	12.0	medium	0	2
thiopental	1	barbiturates	anticonvulsant; drug allergen; environmental contaminant; intravenous anaesthetic; sedative; xenobiotic	2008	2008	16.0	low	1	0
2-octyl-gamma-bromoacetoacetate	1			2008	2008	16.0	high	1	0
arachidonyltrifluoromethane	2	fatty acid derivative; ketone; olefinic compound; organofluorine compound	EC 3.1.1.4 (phospholipase A2) inhibitor	2009	2009	15.0	low	2	0
anandamide	2	endocannabinoid; N-acylethanolamine 20:4	human blood serum metabolite; neurotransmitter; vasodilator agent	2008	2017	11.5	low	1	1
glyceryl 2-arachidonate	1	2-acylglycerol 20:4; endocannabinoid	human metabolite	2017	2017	7.0	low	0	1
oleylamide	1	primary fatty amide	human metabolite; plant metabolite	2008	2008	16.0	low	1	0
arachidonyl-2-chloroethylamide	1	fatty amide; organochlorine compound; secondary carboxamide; synthetic cannabinoid	CB1 receptor agonist; CB2 receptor agonist; neuroprotective agent	2008	2008	16.0	low	1	0
6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2h-pyran-2-one	1	naphthalenes		2008	2008	16.0	low	1	0
sq-23377	1	cyclic ether; enol; polyunsaturated fatty acid; very long-chain fatty acid	calcium ionophore; metabolite	2013	2013	11.0	low	0	1
cay 10499	3	carbamate ester		2009	2017	11.0	high	1	2
CAY10435	2	oxazolopyridine		2011	2017	10.0	high	0	2
urb 524	3			2008	2017	12.0	high	1	2
ol-135	4			2008	2017	12.8	medium	2	2
methyl arachidonylfluorophosphonate	3	phosphonic ester		2008	2009	15.3	high	3	0
urb602	3			2009	2017	12.3	low	2	1
methylphenidate	2			2009	2017	11.0	high	1	1
am 6701	4			2008	2017	11.2	high	1	3
jzl 184	2	benzodioxoles		2009	2013	13.0	low	1	1
pf 3845	1	piperidines		2017	2017	7.0	low	0	1
pf 750	2	quinolines		2013	2017	9.0	high	0	2
urb937	1			2017	2017	7.0	low	0	1
sar127303	1			2017	2017	7.0	high	0	1
mjn110	1			2017	2017	7.0	low	0	1

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	2000's	2010's
gamma-aminobutyric acid	1	amino acid zwitterion; gamma-amino acid; monocarboxylic acid	human metabolite; neurotransmitter; Saccharomyces cerevisiae metabolite; signalling molecule	2012	2012	12.0	low	0	1
carbamates	1	amino-acid anion		2006	2006	18.0	low	1	0
urea	6	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	2006	2018	12.7	low	3	3
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid	1	non-proteinogenic alpha-amino acid		2012	2012	12.0	low	0	1
am 251	1	amidopiperidine; carbohydrazide; dichlorobenzene; organoiodine compound; pyrazoles	antidepressant; antineoplastic agent; apoptosis inducer; CB1 receptor antagonist	2012	2012	12.0	low	0	1
ifosfamide	1	ifosfamides	alkylating agent; antineoplastic agent; environmental contaminant; immunosuppressive agent; xenobiotic	2006	2006	18.0	low	1	0
methylphenidate	1	beta-amino acid ester; methyl ester; piperidines		2014	2014	10.0	low	0	1
mitomycin	1	mitomycin	alkylating agent; antineoplastic agent	2006	2006	18.0	low	1	0
cathinone	1	2-aminopropiophenone; monoamine alkaloid	central nervous system stimulant; psychotropic drug	2014	2014	10.0	low	0	1
urb 597	1	biphenyls		2006	2006	18.0	low	1	0
capsaicin	1	capsaicinoid	non-narcotic analgesic; TRPV1 agonist; voltage-gated sodium channel blocker	2018	2018	6.0	low	0	1
anandamide	1	endocannabinoid; N-acylethanolamine 20:4	human blood serum metabolite; neurotransmitter; vasodilator agent	2008	2008	16.0	low	1	0
glyceryl 2-arachidonate	1	2-acylglycerol 20:4; endocannabinoid	human metabolite	2008	2008	16.0	low	1	0
olvanil	1	methoxybenzenes; phenols		2018	2018	6.0	low	0	1
arvanil	1	methoxybenzenes; phenols		2018	2018	6.0	low	0	1
am 404	1	anilide		2012	2012	12.0	low	0	1
piperidines	1			2012	2012	12.0	low	0	1

Condition	Studies	First Year	Last Year	Average Age	Relationship Strength	2000's	2010's
Absence Seizure	1	2018	2018	6.0	low	0	1
Ache	1	2013	2013	11.0	low	0	1
Alcohol Drinking	1	2010	2010	14.0	low	1	0
Anxiety	1	2010	2010	14.0	low	1	0
Chemical Dependence	1	2014	2014	10.0	low	0	1
Congenital Zika Syndrome	1	2020	2020	4.0	low	0	1
Disease Models, Animal	3	2010	2020	8.0	high	1	2
Pain	1	2013	2013	11.0	low	0	1
Seizures	1	2018	2018	6.0	low	0	1
Substance-Related Disorders	1	2014	2014	10.0	low	0	1
Zika Virus Infection	1	2020	2020	4.0	low	0	1

Bioavailability (1)

Article	Year
Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors. Bioorganic & medicinal chemistry, , Jan-01, Volume: 21, Issue:1	2013

ly2183240

Description

Cross-References

Synonyms (42)

Drug Classes (1)

Protein Targets (11)

Potency Measurements

Inhibition Measurements

Activation Measurements

Bioassays (34)

Research

Studies (18)

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Related Drugs (149)

Drugs in this Class (88)

Drugs Involved in Assays Together (49)

Drugs Researched Together (17)

Related Conditions (11)

Bioavailability (1)