3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1

A 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14060]

Synonyms

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I;
3-beta-HSD I;
3-beta-hydroxy-5-ene steroid dehydrogenase;
3-beta-hydroxy-Delta(5)-steroid dehydrogenase;
1.1.1.145;
3-beta-hydroxysteroid 3-dehydrogenase;
1.1.1.270

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (1)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
finasteride	Homo sapiens (human)	Ki	11.0000	1	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
3-keto sterol reductase activity	molecular function	Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H+. [EC:1.1.1.270, GOC:mah, PMID:9811880]
3-beta-hydroxy-delta5-steroid dehydrogenase activity	molecular function	Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H+. [EC:1.1.1.145]
steroid delta-isomerase activity	molecular function	Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid. [EC:5.3.3.1]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
5alpha-androstane-3beta,17beta-diol dehydrogenase activity	molecular function	Catalysis of the reaction: 5alpha-androstane-3beta,17beta-diol + NADP+ = 17beta-hydroxy-5alpha-androstan-3-one + H+ + NADPH. [EC:1.1.1.210, RHEA:16297]
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	molecular function	Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. [EC:1.1.1.-, GOC:ai]

Located In

This protein is located in 7 target(s):

Target	Category	Definition
nucleolus	cellular component	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. [ISBN:0198506732]
mitochondrial inner membrane	cellular component	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]
mitochondrial intermembrane space	cellular component	The region between the inner and outer lipid bilayers of the mitochondrial envelope. [GOC:mah]
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
smooth endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the smooth endoplasmic reticulum. [GOC:mah]
intercellular bridge	cellular component	A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised. [PMID:9635420]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 6 target(s):

Target	Category	Definition
steroid biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. [GOC:go_curators]
androgen biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. [ISBN:0198506732]
estrogen biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. [ISBN:0198506732]
hippocampus development	biological process	The progression of the hippocampus over time from its initial formation until its mature state. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420, UBERON:0002421]
C21-steroid hormone metabolic process	biological process	The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. [GOC:ai]
response to corticosterone	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses. [PMID:15240347]