Proteins > Platelet-derived growth factor receptor alpha
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Platelet-derived growth factor receptor alpha
An alpha-type platelet-derived growth factor receptor that is encoded in the genome of rat. [OMA:P20786, PRO:DNx]
Synonyms
PDGF-R-alpha;
PDGFR-alpha;
EC 2.7.10.1;
Alpha platelet-derived growth factor receptor;
Alpha-type platelet-derived growth factor receptor;
CD140 antigen-like family member A;
Platelet-derived growth factor alpha receptor
Research
Bioassay Publications (6)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (6)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| pd 173074 | Rattus norvegicus (Norway rat) | IC50 | 17.0000 | 1 | 1 |
| pd 166285 | Rattus norvegicus (Norway rat) | IC50 | 0.0055 | 3 | 3 |
| pd 089828 | Rattus norvegicus (Norway rat) | IC50 | 0.8700 | 2 | 2 |
| pd 166866 | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 2 | 2 |
| pd 161570 | Rattus norvegicus (Norway rat) | IC50 | 0.4033 | 3 | 3 |
| bosutinib | Rattus norvegicus (Norway rat) | IC50 | 4.0000 | 1 | 1 |
2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity.Journal of medicinal chemistry, , Aug-13, Volume: 41, Issue:17, 1998
Synthesis and tyrosine kinase inhibitory activity of a series of 2-amino-8H-pyrido[2,3-d]pyrimidines: identification of potent, selective platelet-derived growth factor receptor tyrosine kinase inhibitors.Journal of medicinal chemistry, , Oct-22, Volume: 41, Issue:22, 1998
Soluble 2-substituted aminopyrido[2,3-d]pyrimidin-7-yl ureas. Structure-activity relationships against selected tyrosine kinases and exploration of in vitro and in vivo anticancer activity.Journal of medicinal chemistry, , Jun-07, Volume: 44, Issue:12, 2001
Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors.Journal of medicinal chemistry, , Jul-18, Volume: 40, Issue:15, 1997