flavin-mononucleotide and Pain

The authors studied the efficiency of the expansion of the standard course of conservative therapy of deforming coxarthrosis by appointment Cytoflavin and behavioral therapy. The study was performed on 104 elderly patients. It was found that the addition of the existing scheme increases the effectiveness of therapeutic interventions, which manifests itself as the improvement of the mental and physical components of quality of life by reducing pain and increasing the functionality of some of the affected hip. At the heart of positive clinical effect is a decrease in processes of inflammation and reduction of tension of regulatory processes in the organism. Positive quality extra medical appointments was the absence of significant side effects when taken orally Cytoflavin requiring discontinuation of the drug, as well as the absence of failure patients from further sessions of behavioral therapy.. Исследована эффективность стандартного курса консервативной терапии деформирующего коксартроза, дополненного Цитофлавином и курсами бихевиоральной терапии, на 104 пациентах пожилого и старческого возраста. Выявлено, что дополнение существующей схемы увеличивает эффективность лечебных мер, что проявляется улучшением как психического, так и физического компонентов качества жизни за счет уменьшения болевого синдрома и некоторого увеличения функциональности пораженного тазобедренного сустава. В основе положительного клинического эффекта лежит уменьшение процессов воспаления и снижение напряженности регуляторных процессов в организме. Положительным качеством дополнительных лечебных назначений стало отсутствие значимых побочных эффектов при пероральном приеме Цитофлавина, требующих его отмены, а также отказов пациентов от дальнейших сеансов бихевиоральной терапии.

Topics: Aged; Cognitive Behavioral Therapy; Combined Modality Therapy; Drug Combinations; Female; Flavin Mononucleotide; Humans; Inosine Diphosphate; Male; Neuroprotective Agents; Niacinamide; Osteoarthritis, Hip; Pain; Pain Management; Quality of Life; Succinates; Treatment Outcome

We reported a 3-year-old girl with myoclonus epilepsy associated with ragged-red fibers (MERRF) who was afflicted with recurrent pain attacks and allodynia on the right side of the body. Although magnetic resonance imaging showed normal intensity in the thalamus, single-photon emission computed tomography (SPECT) revealed hypoperfusion in the thalamus. Somatosensory evoked potentials showed delayed early cortical responses, particularly on right median nerve stimulation. The parenteral administration of cytochrome c with flavin mononucleotide and thiamine diphosphate abolished the intolerable pain. This clinical improvement was objectively supported by the results of SPECT and neurophysiological findings. These observations suggested that a dysfunction of the thalamus was responsible for her pain and that cytochrome c therapy was of benefit for this symptom.

Topics: Child, Preschool; Cytochrome c Group; Epilepsies, Myoclonic; Evoked Potentials, Somatosensory; Female; Flavin Mononucleotide; Humans; Magnetic Resonance Imaging; MERRF Syndrome; Pain; Recurrence; Thalamus; Thiamine; Tomography, Emission-Computed, Single-Photon