bermoprofen profile

bermoprofen: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	54204
CHEMBL ID	10634
CHEBI ID	135248
SCHEMBL ID	25434
MeSH ID	M0119366

Synonyms (35)

Synonym
bermoprofen
dibenon
ad-1590
dl-2-(8-methyl-10,11-dihydro-11-oxodibenz(b,f)oxepin-2-yl)propionic acid
brn 4815717
10,11-dihydro-alpha,8-dimethyl-11-oxo-dibenz(b,f)oxepin-2-acetic acid
bermoprofenum [latin]
bermoprofene [french]
2-(8-methyl-10,11-dihydro-11-oxodibenz(b,f)oxepin-2-yl)propionic
propionic acid, 2-(8-methyl-10,11-dihydro-11-oxodibenz(b,f)oxepin-2-yl)-
dibenz(b,f)oxepin-2-acetic acid, 10,11-dihydro-alpha,8-dimethyl-11-oxo-
bermoprofen [inn]
bermoprofeno [spanish]
CHEBI:135248
CHEMBL10634
aj-1590
2-(8-methyl-5-oxo-6h-benzo[b][1]benzoxepin-3-yl)propanoic acid
78499-27-1
bermoprofeno
bermoprofenum
cwu66767hf ,
unii-cwu66767hf
bermoprofene
bermoprofen [mi]
(+/-)-10,11-dihydro-.alpha.,8-dimethyl-11-oxodibenz(b,f)oxepin-2-acetic acid
bermoprofen [jan]
dibenz(b,f)oxepin-2-acetic acid, 10,11-dihydro-.alpha.,8-dimethyl-11-oxo
bermoprofen [mart.]
SCHEMBL25434
DTXSID30868150
Q27275866
CS-0067478
HY-118561
dibenz[b,f]oxepin-2-acetic acid, 10,11-dihydro-a,8-dimethyl-11-oxo-
AKOS040741319

Excerpt	Relevance	Reference
"5%) greater than RRG(4%) after a single oral dosage in rats."	( Prolongation of antipyretic action and reduction of gastric ulcerogenicity in the rat by controlled-release granules of bermoprofen, a new nonsteroidal anti-inflammatory drug. Imasato, Y; Makita, H; Mori, M; Nakamura, H; Nakamura, Y; Seto, Y; Shirai, Y, 1991)	0.49
" AD-1590 and indomethacin at an oral dosage as high as 32 mg/kg did not show any significant inhibitory activity on rat passive cutaneous anaphylaxis, a type-I allergy, although prednisolone and cyproheptadine produced strong inhibition."	( [Inhibitory effect of AD-1590, a non-steroidal anti-inflammatory drug, on allergic inflammation in mice and rats]. Ishii, K; Kadokawa, T; Motoyoshi, S; Nakamura, H, 1988)	0.27

Class	Description
dibenzooxazepine	An organic heterotricyclic compound consisting of two benzene rings fused to a seven-membered ring containing one oxygen and one nitrogen atom.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (8)

Assay ID	Title	Year	Journal	Article
AID27371	Lethal dose determined in rats when administered perorally	1982	Journal of medicinal chemistry, Sep, Volume: 25, Issue:9	Nonsteroidal antiinflammatory agents. 1. 10,11-Dihydro-11-oxodibenz[b, f]oxepinacetic acids and related compounds.
AID178845	Antipyretic activity measured as yeast induced fever assay in rats	1982	Journal of medicinal chemistry, Sep, Volume: 25, Issue:9	Nonsteroidal antiinflammatory agents. 1. 10,11-Dihydro-11-oxodibenz[b, f]oxepinacetic acids and related compounds.
AID177762	Analgesic activity measured as silver nitrate induced arthritic pain in rats	1982	Journal of medicinal chemistry, Sep, Volume: 25, Issue:9	Nonsteroidal antiinflammatory agents. 1. 10,11-Dihydro-11-oxodibenz[b, f]oxepinacetic acids and related compounds.
AID74200	Antiinflammatory activity measured as effect on ultraviolet induced erythema in guinea pigs	1982	Journal of medicinal chemistry, Sep, Volume: 25, Issue:9	Nonsteroidal antiinflammatory agents. 1. 10,11-Dihydro-11-oxodibenz[b, f]oxepinacetic acids and related compounds.
AID177425	Compound was evaluated for the induction of gastric ulcers in rats after oral administration	1982	Journal of medicinal chemistry, Sep, Volume: 25, Issue:9	Nonsteroidal antiinflammatory agents. 1. 10,11-Dihydro-11-oxodibenz[b, f]oxepinacetic acids and related compounds.
AID177761	Analgesic activity measured as acetic acid writhing in rats	1982	Journal of medicinal chemistry, Sep, Volume: 25, Issue:9	Nonsteroidal antiinflammatory agents. 1. 10,11-Dihydro-11-oxodibenz[b, f]oxepinacetic acids and related compounds.
AID178033	Effective dose for antiinflammatory activity in carrageenan paw edema assay in rats after oral administration	1982	Journal of medicinal chemistry, Sep, Volume: 25, Issue:9	Nonsteroidal antiinflammatory agents. 1. 10,11-Dihydro-11-oxodibenz[b, f]oxepinacetic acids and related compounds.
AID131689	Effective dose for analgesic activity in mice	1982	Journal of medicinal chemistry, Sep, Volume: 25, Issue:9	Nonsteroidal antiinflammatory agents. 1. 10,11-Dihydro-11-oxodibenz[b, f]oxepinacetic acids and related compounds.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	14 (93.33)	18.7374
1990's	1 (6.67)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
ibuprofen Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine	1.97	1	monocarboxylic acid	antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; environmental contaminant; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug; radical scavenger; xenobiotic
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	3.06	5	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
erythromycin Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.. erythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).. erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.	1.96	1	cyclic ketone; erythromycin
betadex beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.	1.96	1	cyclodextrin
arachidonic acid icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.	1.96	1	icosa-5,8,11,14-tetraenoic acid; long-chain fatty acid; omega-6 fatty acid	Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite; mouse metabolite
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	2.88	4	prostaglandins E	human metabolite; mouse metabolite; oxytocic

Condition	Relationship Strength	Studies
Adjuvant Arthritis [description not available]	2.37	2
Anasarca [description not available]	2.37	2
Gastric Ulcer [description not available]	7.66	3
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	2.37	2
Erythema Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.	2.65	3
Stomach Ulcer Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).	2.66	3
Pyrexia [description not available]	2.65	3
Fever An abnormal elevation of body temperature, usually as a result of a pathologic process.	2.65	3
Innate Inflammatory Response [description not available]	1.96	1
Ache [description not available]	1.96	1
Gastroduodenal Ulcer [description not available]	1.96	1
Pleurisy INFLAMMATION of PLEURA, the lining of the LUNG. When PARIETAL PLEURA is involved, there is pleuritic CHEST PAIN.	1.96	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	1.96	1
Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	1.96	1
Peptic Ulcer Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).	1.96	1
Polyarthritis [description not available]	1.97	1
Contact Dermatitis [description not available]	1.97	1
Arthritis Acute or chronic inflammation of JOINTS.	1.97	1
Dermatitis, Contact A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.	1.97	1

bermoprofen

Description

Cross-References

Synonyms (35)

Research Excerpts

Dosage Studied

Drug Classes (1)

Bioassays (8)

Research

Studies (15)

Study Types

bermoprofen

Description

Cross-References

Synonyms (35)

Research Excerpts

Dosage Studied

Drug Classes (1)

Bioassays (8)

Research

Studies (15)

Study Types

Related Drugs (6)

Related Conditions (19)