Page last updated: 2024-10-31

mianserin and Pain

mianserin has been researched along with Pain in 22 studies

Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"The reduction of pain by two antidepressants, clomipramine and mianserin, was, in this study on 253 patients with chronic idiopathic pain syndrome, found to be not better than a placebo when all patients were compared independently of the classification of pain."9.06Clomipramine and mianserin in chronic idiopathic pain syndrome. A placebo controlled study. ( Bech, P; Hansen, HJ; Langemark, M; Loldrup, D; Olesen, J, 1989)
"To investigate whether the tetracyclic antidepressant mirtazapine has a pain-suppressing effect in healthy animals."7.77The acute effects of mirtazapine on pain related behavior in healthy animals. ( Baydemir, C; Dogan, AE; Erol, K; Kilic, FS, 2011)
"The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine (antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) and the selective serotonin reuptake inhibitor (SSRI) citalopram were compared in rat models of experimental pain."7.73Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. ( Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD, 2005)
"To evaluate the safety, tolerability and efficacy of mirtazapine in patients with the primary diagnosis of chronic pain and concomitant depression in an open post-marketing surveillance study."7.73The effect of mirtazapine in patients with chronic pain and concomitant depression. ( Freynhagen, R; Lipfert, P; Muth-Selbach, U; Stevens, MF; Tölle, TR; von Giesen, HJ; Zacharowski, K, 2006)
"To report a case of serotonin syndrome (SS) resulting from the addition of tramadol to a medication regimen of venlafaxine and mirtazapine."7.72Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine. ( Houlihan, DJ, 2004)
"Tritiated imipramine binding to whole platelets was measured in 16 chronic pain patients who were free from major depression, and in a control group."7.67Modifications of [3H]imipramine binding sites in platelets of chronic pain patients treated with mianserin. ( Ambrosio, F; Andreoli, F; Arduino, C; Arsie, D; Ceccherelli, F; Dodi, G; Eandi, M; Magni, G, 1987)
"This study aimed to compare the effectiveness of mirtazapine and imipramine on not only the distressing symptoms of cancer patients such as pain, nausea, vomiting, appetite loss, and sleep disturbances but also depressive and anxiety symptoms."5.13Mirtazapine improves sleep and lowers anxiety and depression in cancer patients: superiority over imipramine. ( Akbiyik, DI; Alkis, N; Cankurtaran, ES; Ozalp, E; Soygur, H; Turhan, L, 2008)
"The reduction of pain by two antidepressants, clomipramine and mianserin, was, in this study on 253 patients with chronic idiopathic pain syndrome, found to be not better than a placebo when all patients were compared independently of the classification of pain."5.06Clomipramine and mianserin in chronic idiopathic pain syndrome. A placebo controlled study. ( Bech, P; Hansen, HJ; Langemark, M; Loldrup, D; Olesen, J, 1989)
"To investigate whether the tetracyclic antidepressant mirtazapine has a pain-suppressing effect in healthy animals."3.77The acute effects of mirtazapine on pain related behavior in healthy animals. ( Baydemir, C; Dogan, AE; Erol, K; Kilic, FS, 2011)
"The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine (antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) and the selective serotonin reuptake inhibitor (SSRI) citalopram were compared in rat models of experimental pain."3.73Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. ( Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD, 2005)
"To evaluate the safety, tolerability and efficacy of mirtazapine in patients with the primary diagnosis of chronic pain and concomitant depression in an open post-marketing surveillance study."3.73The effect of mirtazapine in patients with chronic pain and concomitant depression. ( Freynhagen, R; Lipfert, P; Muth-Selbach, U; Stevens, MF; Tölle, TR; von Giesen, HJ; Zacharowski, K, 2006)
"To report a case of serotonin syndrome (SS) resulting from the addition of tramadol to a medication regimen of venlafaxine and mirtazapine."3.72Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine. ( Houlihan, DJ, 2004)
"Tritiated imipramine binding to whole platelets was measured in 16 chronic pain patients who were free from major depression, and in a control group."3.67Modifications of [3H]imipramine binding sites in platelets of chronic pain patients treated with mianserin. ( Ambrosio, F; Andreoli, F; Arduino, C; Arsie, D; Ceccherelli, F; Dodi, G; Eandi, M; Magni, G, 1987)
"Clomipramine and mianserin were significantly superior to placebo in the topographical pain subgroup with headache using area under the improvement curves as criteria (p less than 0."2.66Discomfort or disability in patients with chronic pain syndrome. ( Bech, P; Hansen, HJ; Langemark, M; Olesen, J; Poulsen, DL, 1987)
"Buspirone has an indication for generalized anxiety disorder though studies show only a minimal benefit."2.53Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD. ( Bielefeldt, K; Szigethy, E; Thorkelson, G, 2016)
" With chronic administration each of the antidepressants produced effects which could potentially interfere with CRF function in the LC."2.38Pharmacology of locus coeruleus spontaneous and sensory-evoked activity. ( Curtis, AL; Valentino, RJ, 1991)
"Mianserin was administered to mice 30min before applying the analgesic drugs."1.31Influence of mianserin on the antinociceptive effect of morphine, metamizol and indomethacin in mice. ( Czarnecka, E; Pakulska, W, 2002)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19903 (13.64)18.7374
1990's5 (22.73)18.2507
2000's11 (50.00)29.6817
2010's2 (9.09)24.3611
2020's1 (4.55)2.80

Authors

AuthorsStudies
Sato, A1
Yasui-Furukori, N1
Oda, Y1
Yang, M1
Suzuki, Y1
Shinozaki, M1
Shimizu, T1
Shimoda, K1
Thorkelson, G1
Bielefeldt, K1
Szigethy, E1
Kilic, FS1
Dogan, AE1
Baydemir, C1
Erol, K1
Ji, GC1
Zhang, YQ1
Ma, F1
Wu, GC1
Pakulska, W1
Czarnecka, E1
Houlihan, DJ1
Bomholt, SF1
Mikkelsen, JD1
Blackburn-Munro, G1
Kling, A1
Dahlqvist, R1
Johansson, S1
Bäckström, M1
Mjörndal, T1
Klein, JP1
Fiedler, U1
Appel, H1
Quante, A1
Jockers-Scherübl, MC1
Freynhagen, R2
Muth-Selbach, U2
Lipfert, P2
Stevens, MF1
Zacharowski, K1
Tölle, TR1
von Giesen, HJ1
Vogt, J1
Cankurtaran, ES1
Ozalp, E1
Soygur, H1
Akbiyik, DI1
Turhan, L1
Alkis, N1
Onghena, P2
De Cuyper, H2
Van Houdenhove, B2
Verstraeten, D2
Millan, MJ1
Gobert, A1
Rivet, JM1
Adhumeau-Auclair, A1
Cussac, D1
Newman-Tancredi, A1
Dekeyne, A1
Nicolas, JP1
Lejeune, F1
Valentino, RJ1
Curtis, AL1
Giordano, J1
Ostensen, M1
Myhr, K1
Loldrup, D1
Langemark, M2
Hansen, HJ2
Olesen, J2
Bech, P2
Poulsen, DL1
Magni, G1
Andreoli, F1
Arduino, C1
Arsie, D1
Ceccherelli, F1
Ambrosio, F1
Dodi, G1
Eandi, M1

Reviews

2 reviews available for mianserin and Pain

ArticleYear
Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD.
    Inflammatory bowel diseases, 2016, Volume: 22, Issue:6

    Topics: Adolescent; Adult; Affect; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Bupropion

2016
Pharmacology of locus coeruleus spontaneous and sensory-evoked activity.
    Progress in brain research, 1991, Volume: 88

    Topics: 1-Naphthylamine; Action Potentials; Animals; Antidepressive Agents; Corticotropin-Releasing Hormone;

1991

Trials

5 trials available for mianserin and Pain

ArticleYear
Mirtazapine improves sleep and lowers anxiety and depression in cancer patients: superiority over imipramine.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2008, Volume: 16, Issue:11

    Topics: Adaptation, Psychological; Adjustment Disorders; Adrenergic alpha-Antagonists; Adult; Antidepressive

2008
Mianserin and chronic pain: a double-blind placebo-controlled process and outcome study.
    Acta psychiatrica Scandinavica, 1993, Volume: 88, Issue:3

    Topics: Adult; Chronic Disease; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Mianserin; M

1993
Chronic idiopathic pain, mianserin and 'masked' depression.
    Psychotherapy and psychosomatics, 1992, Volume: 58, Issue:1

    Topics: Adult; Chronic Disease; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Mianserin; M

1992
Clomipramine and mianserin in chronic idiopathic pain syndrome. A placebo controlled study.
    Psychopharmacology, 1989, Volume: 99, Issue:1

    Topics: Adolescent; Adult; Aged; Chronic Disease; Clinical Trials as Topic; Clomipramine; Female; Humans; Ma

1989
Discomfort or disability in patients with chronic pain syndrome.
    Psychotherapy and psychosomatics, 1987, Volume: 48, Issue:1-4

    Topics: Clinical Trials as Topic; Clomipramine; Disability Evaluation; Double-Blind Method; Humans; Mianseri

1987

Other Studies

15 other studies available for mianserin and Pain

ArticleYear
Asymptomatic syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following duloxetine treatment for pain with depression: Two case reports.
    Neuropsychopharmacology reports, 2022, Volume: 42, Issue:3

    Topics: Aged; Aged, 80 and over; Depression; Duloxetine Hydrochloride; Female; Humans; Hyponatremia; Inappro

2022
The acute effects of mirtazapine on pain related behavior in healthy animals.
    Neurosciences (Riyadh, Saudi Arabia), 2011, Volume: 16, Issue:3

    Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Arginine; Behavior, Animal; Cyprohe

2011
Increase of nociceptive threshold induced by intrathecal injection of interleukin-1beta in normal and carrageenan inflammatory rat.
    Cytokine, 2002, Jul-07, Volume: 19, Issue:1

    Topics: Animals; Carrageenan; Inflammation; Injections, Spinal; Interleukin-1; Male; Mianserin; Naloxone; Na

2002
Influence of mianserin on the antinociceptive effect of morphine, metamizol and indomethacin in mice.
    Pharmacological research, 2002, Volume: 46, Issue:5

    Topics: Analgesics; Animals; Antidepressive Agents, Second-Generation; Dipyrone; Drug Synergism; Drug Therap

2002
[Unclear chronic aches. Often depression plays a part therein].
    MMW Fortschritte der Medizin, 2003, May-26, Volume: 145 Suppl 2

    Topics: Acetates; Amines; Analgesics, Opioid; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Age

2003
Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine.
    The Annals of pharmacotherapy, 2004, Volume: 38, Issue:3

    Topics: Analgesics, Opioid; Antidepressive Agents; Cyclohexanols; Depressive Disorder; Humans; Male; Mianser

2004
Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain.
    Neuropharmacology, 2005, Volume: 48, Issue:2

    Topics: Acute Disease; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Chronic Disease; Citalopra

2005
Neurologic oral manifestations caused by a new formulation of mirtazapine.
    Neurology, 2005, Jul-26, Volume: 65, Issue:2

    Topics: Administration, Oral; Antidepressive Agents, Tricyclic; Dose-Response Relationship, Drug; Extremitie

2005
Massive creatine kinase elevations with quetiapine: report of two cases.
    Pharmacopsychiatry, 2006, Volume: 39, Issue:1

    Topics: Adult; Aged; Antipsychotic Agents; Benzodiazepines; Clozapine; Creatine Kinase; Depressive Disorder,

2006
The effect of mirtazapine in patients with chronic pain and concomitant depression.
    Current medical research and opinion, 2006, Volume: 22, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Chronic Disease; Depre

2006
Mirtazapine and its enantiomers differentially modulate acute thermal nociception in rats.
    Brain research bulletin, 2006, Mar-31, Volume: 69, Issue:2

    Topics: Afferent Pathways; Animals; Antidepressive Agents, Tricyclic; Central Nervous System; Disease Models

2006
Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha2-adrenergic and serotonin2C receptors: a comparison with citalopram.
    The European journal of neuroscience, 2000, Volume: 12, Issue:3

    Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antidepressive Agents, Tricyclic; Cerebral Cortex;

2000
Analgesic profile of centrally administered 2-methylserotonin against acute pain in rats.
    European journal of pharmacology, 1991, Jun-25, Volume: 199, Issue:2

    Topics: Analgesics; Animals; Bicuculline; Dose-Response Relationship, Drug; Injections, Intraventricular; In

1991
Mianserin as a cause of arthritis.
    British journal of rheumatology, 1991, Volume: 30, Issue:1

    Topics: Arthritis; Depression; Humans; Joint Diseases; Mianserin; Pain

1991
Modifications of [3H]imipramine binding sites in platelets of chronic pain patients treated with mianserin.
    Pain, 1987, Volume: 30, Issue:3

    Topics: Binding Sites; Blood Platelets; Chronic Disease; Depressive Disorder; Female; Humans; Imipramine; Ma

1987