mianserin has been researched along with Pain in 22 studies
Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The reduction of pain by two antidepressants, clomipramine and mianserin, was, in this study on 253 patients with chronic idiopathic pain syndrome, found to be not better than a placebo when all patients were compared independently of the classification of pain." | 9.06 | Clomipramine and mianserin in chronic idiopathic pain syndrome. A placebo controlled study. ( Bech, P; Hansen, HJ; Langemark, M; Loldrup, D; Olesen, J, 1989) |
| "To investigate whether the tetracyclic antidepressant mirtazapine has a pain-suppressing effect in healthy animals." | 7.77 | The acute effects of mirtazapine on pain related behavior in healthy animals. ( Baydemir, C; Dogan, AE; Erol, K; Kilic, FS, 2011) |
| "The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine (antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) and the selective serotonin reuptake inhibitor (SSRI) citalopram were compared in rat models of experimental pain." | 7.73 | Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. ( Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD, 2005) |
| "To evaluate the safety, tolerability and efficacy of mirtazapine in patients with the primary diagnosis of chronic pain and concomitant depression in an open post-marketing surveillance study." | 7.73 | The effect of mirtazapine in patients with chronic pain and concomitant depression. ( Freynhagen, R; Lipfert, P; Muth-Selbach, U; Stevens, MF; Tölle, TR; von Giesen, HJ; Zacharowski, K, 2006) |
| "To report a case of serotonin syndrome (SS) resulting from the addition of tramadol to a medication regimen of venlafaxine and mirtazapine." | 7.72 | Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine. ( Houlihan, DJ, 2004) |
| "Tritiated imipramine binding to whole platelets was measured in 16 chronic pain patients who were free from major depression, and in a control group." | 7.67 | Modifications of [3H]imipramine binding sites in platelets of chronic pain patients treated with mianserin. ( Ambrosio, F; Andreoli, F; Arduino, C; Arsie, D; Ceccherelli, F; Dodi, G; Eandi, M; Magni, G, 1987) |
| "This study aimed to compare the effectiveness of mirtazapine and imipramine on not only the distressing symptoms of cancer patients such as pain, nausea, vomiting, appetite loss, and sleep disturbances but also depressive and anxiety symptoms." | 5.13 | Mirtazapine improves sleep and lowers anxiety and depression in cancer patients: superiority over imipramine. ( Akbiyik, DI; Alkis, N; Cankurtaran, ES; Ozalp, E; Soygur, H; Turhan, L, 2008) |
| "The reduction of pain by two antidepressants, clomipramine and mianserin, was, in this study on 253 patients with chronic idiopathic pain syndrome, found to be not better than a placebo when all patients were compared independently of the classification of pain." | 5.06 | Clomipramine and mianserin in chronic idiopathic pain syndrome. A placebo controlled study. ( Bech, P; Hansen, HJ; Langemark, M; Loldrup, D; Olesen, J, 1989) |
| "To investigate whether the tetracyclic antidepressant mirtazapine has a pain-suppressing effect in healthy animals." | 3.77 | The acute effects of mirtazapine on pain related behavior in healthy animals. ( Baydemir, C; Dogan, AE; Erol, K; Kilic, FS, 2011) |
| "The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine (antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) and the selective serotonin reuptake inhibitor (SSRI) citalopram were compared in rat models of experimental pain." | 3.73 | Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. ( Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD, 2005) |
| "To evaluate the safety, tolerability and efficacy of mirtazapine in patients with the primary diagnosis of chronic pain and concomitant depression in an open post-marketing surveillance study." | 3.73 | The effect of mirtazapine in patients with chronic pain and concomitant depression. ( Freynhagen, R; Lipfert, P; Muth-Selbach, U; Stevens, MF; Tölle, TR; von Giesen, HJ; Zacharowski, K, 2006) |
| "To report a case of serotonin syndrome (SS) resulting from the addition of tramadol to a medication regimen of venlafaxine and mirtazapine." | 3.72 | Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine. ( Houlihan, DJ, 2004) |
| "Tritiated imipramine binding to whole platelets was measured in 16 chronic pain patients who were free from major depression, and in a control group." | 3.67 | Modifications of [3H]imipramine binding sites in platelets of chronic pain patients treated with mianserin. ( Ambrosio, F; Andreoli, F; Arduino, C; Arsie, D; Ceccherelli, F; Dodi, G; Eandi, M; Magni, G, 1987) |
| "Clomipramine and mianserin were significantly superior to placebo in the topographical pain subgroup with headache using area under the improvement curves as criteria (p less than 0." | 2.66 | Discomfort or disability in patients with chronic pain syndrome. ( Bech, P; Hansen, HJ; Langemark, M; Olesen, J; Poulsen, DL, 1987) |
| "Buspirone has an indication for generalized anxiety disorder though studies show only a minimal benefit." | 2.53 | Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD. ( Bielefeldt, K; Szigethy, E; Thorkelson, G, 2016) |
| " With chronic administration each of the antidepressants produced effects which could potentially interfere with CRF function in the LC." | 2.38 | Pharmacology of locus coeruleus spontaneous and sensory-evoked activity. ( Curtis, AL; Valentino, RJ, 1991) |
| "Mianserin was administered to mice 30min before applying the analgesic drugs." | 1.31 | Influence of mianserin on the antinociceptive effect of morphine, metamizol and indomethacin in mice. ( Czarnecka, E; Pakulska, W, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (13.64) | 18.7374 |
| 1990's | 5 (22.73) | 18.2507 |
| 2000's | 11 (50.00) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Sato, A | 1 |
| Yasui-Furukori, N | 1 |
| Oda, Y | 1 |
| Yang, M | 1 |
| Suzuki, Y | 1 |
| Shinozaki, M | 1 |
| Shimizu, T | 1 |
| Shimoda, K | 1 |
| Thorkelson, G | 1 |
| Bielefeldt, K | 1 |
| Szigethy, E | 1 |
| Kilic, FS | 1 |
| Dogan, AE | 1 |
| Baydemir, C | 1 |
| Erol, K | 1 |
| Ji, GC | 1 |
| Zhang, YQ | 1 |
| Ma, F | 1 |
| Wu, GC | 1 |
| Pakulska, W | 1 |
| Czarnecka, E | 1 |
| Houlihan, DJ | 1 |
| Bomholt, SF | 1 |
| Mikkelsen, JD | 1 |
| Blackburn-Munro, G | 1 |
| Kling, A | 1 |
| Dahlqvist, R | 1 |
| Johansson, S | 1 |
| Bäckström, M | 1 |
| Mjörndal, T | 1 |
| Klein, JP | 1 |
| Fiedler, U | 1 |
| Appel, H | 1 |
| Quante, A | 1 |
| Jockers-Scherübl, MC | 1 |
| Freynhagen, R | 2 |
| Muth-Selbach, U | 2 |
| Lipfert, P | 2 |
| Stevens, MF | 1 |
| Zacharowski, K | 1 |
| Tölle, TR | 1 |
| von Giesen, HJ | 1 |
| Vogt, J | 1 |
| Cankurtaran, ES | 1 |
| Ozalp, E | 1 |
| Soygur, H | 1 |
| Akbiyik, DI | 1 |
| Turhan, L | 1 |
| Alkis, N | 1 |
| Onghena, P | 2 |
| De Cuyper, H | 2 |
| Van Houdenhove, B | 2 |
| Verstraeten, D | 2 |
| Millan, MJ | 1 |
| Gobert, A | 1 |
| Rivet, JM | 1 |
| Adhumeau-Auclair, A | 1 |
| Cussac, D | 1 |
| Newman-Tancredi, A | 1 |
| Dekeyne, A | 1 |
| Nicolas, JP | 1 |
| Lejeune, F | 1 |
| Valentino, RJ | 1 |
| Curtis, AL | 1 |
| Giordano, J | 1 |
| Ostensen, M | 1 |
| Myhr, K | 1 |
| Loldrup, D | 1 |
| Langemark, M | 2 |
| Hansen, HJ | 2 |
| Olesen, J | 2 |
| Bech, P | 2 |
| Poulsen, DL | 1 |
| Magni, G | 1 |
| Andreoli, F | 1 |
| Arduino, C | 1 |
| Arsie, D | 1 |
| Ceccherelli, F | 1 |
| Ambrosio, F | 1 |
| Dodi, G | 1 |
| Eandi, M | 1 |
2 reviews available for mianserin and Pain
| Article | Year |
|---|---|
Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD.
Topics: Adolescent; Adult; Affect; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Bupropion | 2016 |
Pharmacology of locus coeruleus spontaneous and sensory-evoked activity.
Topics: 1-Naphthylamine; Action Potentials; Animals; Antidepressive Agents; Corticotropin-Releasing Hormone; | 1991 |
5 trials available for mianserin and Pain
| Article | Year |
|---|---|
Mirtazapine improves sleep and lowers anxiety and depression in cancer patients: superiority over imipramine.
Topics: Adaptation, Psychological; Adjustment Disorders; Adrenergic alpha-Antagonists; Adult; Antidepressive | 2008 |
Mianserin and chronic pain: a double-blind placebo-controlled process and outcome study.
Topics: Adult; Chronic Disease; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Mianserin; M | 1993 |
Chronic idiopathic pain, mianserin and 'masked' depression.
Topics: Adult; Chronic Disease; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Mianserin; M | 1992 |
Clomipramine and mianserin in chronic idiopathic pain syndrome. A placebo controlled study.
Topics: Adolescent; Adult; Aged; Chronic Disease; Clinical Trials as Topic; Clomipramine; Female; Humans; Ma | 1989 |
Discomfort or disability in patients with chronic pain syndrome.
Topics: Clinical Trials as Topic; Clomipramine; Disability Evaluation; Double-Blind Method; Humans; Mianseri | 1987 |
15 other studies available for mianserin and Pain
| Article | Year |
|---|---|
Asymptomatic syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following duloxetine treatment for pain with depression: Two case reports.
Topics: Aged; Aged, 80 and over; Depression; Duloxetine Hydrochloride; Female; Humans; Hyponatremia; Inappro | 2022 |
The acute effects of mirtazapine on pain related behavior in healthy animals.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Arginine; Behavior, Animal; Cyprohe | 2011 |
Increase of nociceptive threshold induced by intrathecal injection of interleukin-1beta in normal and carrageenan inflammatory rat.
Topics: Animals; Carrageenan; Inflammation; Injections, Spinal; Interleukin-1; Male; Mianserin; Naloxone; Na | 2002 |
Influence of mianserin on the antinociceptive effect of morphine, metamizol and indomethacin in mice.
Topics: Analgesics; Animals; Antidepressive Agents, Second-Generation; Dipyrone; Drug Synergism; Drug Therap | 2002 |
[Unclear chronic aches. Often depression plays a part therein].
Topics: Acetates; Amines; Analgesics, Opioid; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Age | 2003 |
Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine.
Topics: Analgesics, Opioid; Antidepressive Agents; Cyclohexanols; Depressive Disorder; Humans; Male; Mianser | 2004 |
Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain.
Topics: Acute Disease; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Chronic Disease; Citalopra | 2005 |
Neurologic oral manifestations caused by a new formulation of mirtazapine.
Topics: Administration, Oral; Antidepressive Agents, Tricyclic; Dose-Response Relationship, Drug; Extremitie | 2005 |
Massive creatine kinase elevations with quetiapine: report of two cases.
Topics: Adult; Aged; Antipsychotic Agents; Benzodiazepines; Clozapine; Creatine Kinase; Depressive Disorder, | 2006 |
The effect of mirtazapine in patients with chronic pain and concomitant depression.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Chronic Disease; Depre | 2006 |
Mirtazapine and its enantiomers differentially modulate acute thermal nociception in rats.
Topics: Afferent Pathways; Animals; Antidepressive Agents, Tricyclic; Central Nervous System; Disease Models | 2006 |
Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha2-adrenergic and serotonin2C receptors: a comparison with citalopram.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antidepressive Agents, Tricyclic; Cerebral Cortex; | 2000 |
Analgesic profile of centrally administered 2-methylserotonin against acute pain in rats.
Topics: Analgesics; Animals; Bicuculline; Dose-Response Relationship, Drug; Injections, Intraventricular; In | 1991 |
Mianserin as a cause of arthritis.
Topics: Arthritis; Depression; Humans; Joint Diseases; Mianserin; Pain | 1991 |
Modifications of [3H]imipramine binding sites in platelets of chronic pain patients treated with mianserin.
Topics: Binding Sites; Blood Platelets; Chronic Disease; Depressive Disorder; Female; Humans; Imipramine; Ma | 1987 |