| Assay ID | Title | Year | Journal | Article |
|---|
| AID709669 | Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cell membranes incubated for 60 mins by liquid scintillation counting | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. |
| AID1610003 | Inhibition of kappa opioid receptor (unknown origin) assessed as increase in beta-arrestin 2 recruitment | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Progress in the development of more effective and safer analgesics for pain management. |
| AID1609981 | Inhibition of kappa opioid receptor (unknown origin) by [35S]-GTPgammaS binding assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Progress in the development of more effective and safer analgesics for pain management. |
| AID709655 | Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. |
| AID709661 | Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cells | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. |
| AID709664 | Agonist activity at human kappa opioid receptor expressed in CHO cell membranes incubated for 60 mins by [35S]GTPgammaS binding assay | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. |
| AID709652 | Analgesic activity in CD1 mouse assessed as inhibition of acetic acid induced writhing dosed subcutaneously 30 mins before acetic acid challenge | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. |
| AID1875774 | Agonist activity at KOR in guinea pig brain membranes assessed as stimulation of [35S]GTPgammaS binding measured after 1 hr by liquid scintillation counting analysis | 2022 | ACS medicinal chemistry letters, Nov-10, Volume: 13, Issue:11
| Discovery of κ Opioid Receptor (KOR)-Selective d-Tetrapeptides with Improved |
| AID1875773 | Agonist activity at KOR in guinea pig brain membranes assessed as stimulation of [35S]GTPgammaS binding measured after 1 hr by liquid scintillation counting analysis relative to control | 2022 | ACS medicinal chemistry letters, Nov-10, Volume: 13, Issue:11
| Discovery of κ Opioid Receptor (KOR)-Selective d-Tetrapeptides with Improved |
| AID709653 | Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirol-induced mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. |
| AID1875771 | Displacement of [3H]-HS665 from DOR in rat brain membranes | 2022 | ACS medicinal chemistry letters, Nov-10, Volume: 13, Issue:11
| Discovery of κ Opioid Receptor (KOR)-Selective d-Tetrapeptides with Improved |
| AID1875770 | Displacement of [3H]-HS665 from MOR in rat brain membranes | 2022 | ACS medicinal chemistry letters, Nov-10, Volume: 13, Issue:11
| Discovery of κ Opioid Receptor (KOR)-Selective d-Tetrapeptides with Improved |
| AID1610004 | Inhibition of kappa opioid receptor (unknown origin) assessed as increase in beta-arrestin 2 recruitment relative to control | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Progress in the development of more effective and safer analgesics for pain management. |
| AID709668 | Agonist activity at human kappa opioid receptor expressed in CHO cell membranes incubated for 60 mins by [35S]GTPgammaS binding assay relative to U69,593 | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. |
| AID709663 | Selectivity index, ratio of KI for human delta opioid receptor to KI for human kappa opioid receptor | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. |
| AID709667 | Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cell membranes incubated for 60 mins by liquid scintillation counting | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. |
| AID1875772 | Displacement of [3H]-HS665 from KOR in guinea pig brain membranes | 2022 | ACS medicinal chemistry letters, Nov-10, Volume: 13, Issue:11
| Discovery of κ Opioid Receptor (KOR)-Selective d-Tetrapeptides with Improved |
| AID1451337 | Toxicity in CD-1 mouse assessed as motor impairment at 5 to 10 mg/kg, sc treated 30 mins prior to test by rotarod test | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Highly Potent and Selective New Diphenethylamines Interacting with the κ-Opioid Receptor: Synthesis, Pharmacology, and Structure-Activity Relationships. |
| AID709656 | Antagonist activity at human dopamine D2 receptor expressed in CHOp cells assessed as inhibition of quinpirol-induced mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. |
| AID709651 | Analgesic activity in CD1 mouse assessed as inhibition of acetic acid induced writhing at 2.5 mg/kg, sc dosed 30 mins before acetic acid challenge in presence of 20 mg/kg, sc KOP receptor antagonist nor-BNI | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. |
| AID709666 | Displacement of [3H]pCl-DPDPE from human delta opioid receptor expressed in CHO cell membranes incubated for 60 mins by liquid scintillation counting | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. |
| AID709659 | Displacement of [3H]YM-09151-2 from human dopamine D2 receptor expressed in CHOp cells | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. |
| AID1609994 | Antinociceptive activity in icv dosed mouse | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Progress in the development of more effective and safer analgesics for pain management. |
| AID709660 | Displacement of [3H]YM-09151-2 from human dopamine D3 receptor expressed in CHOp cells | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. |
| AID709658 | Agonist activity at human dopamine D2 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. |
| AID1609982 | Inhibition of kappa opioid receptor (unknown origin) by [35S]-GTPgammaS binding assay relative to control | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Progress in the development of more effective and safer analgesics for pain management. |
| AID709665 | Selectivity index, ratio of KI for human mu opioid receptor to KI for human kappa opioid receptor | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. |
| AID1346364 | Human mu receptor (Opioid receptors) | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. |
| AID1346329 | Human kappa receptor (Opioid receptors) | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. |
| AID1345788 | Human D2 receptor (Dopamine receptors) | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. |
| AID1345833 | Human D3 receptor (Dopamine receptors) | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |