pimagedine and Pain
pimagedine has been researched along with Pain in 11 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Morphine is one of the strongest analgesics and is commonly used for the treatment of chronic pain." | 3.77 | Decreased expression of intestinal P-glycoprotein increases the analgesic effects of oral morphine in a streptozotocin-induced diabetic mouse model. ( Fujita-Hamabe, W; Kishioka, S; Nawa, A; Tokuyama, S, 2011) |
| " Also, the development of morphine dependence as assessed by naloxone-precipitated withdrawal manifestations was reduced by co-administration of aminoguanidine." | 3.73 | Attenuation of morphine tolerance and dependence by aminoguanidine in mice. ( Abdel-Hady, RH; Abdel-Rahman, S; Abdel-Zaher, AO; Aly, SA; Hamdy, MM, 2006) |
Research
Studies (11)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (72.73) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Sandes, SMS | 1 |
| Heimfarth, L | 1 |
| Brito, RG | 1 |
| Santos, PL | 1 |
| Gouveia, DN | 1 |
| Carvalho, AMS | 1 |
| Quintans, JSS | 1 |
| da Silva-Júnior, EF | 1 |
| de Aquino, TM | 1 |
| França, PHB | 1 |
| de Araújo-Júnior, JX | 1 |
| Albuquerque-Júnior, RLC | 1 |
| Zengin, G | 1 |
| Schmitt, M | 1 |
| Bourguignon, JJ | 1 |
| Quintans-Júnior, LJ | 1 |
| Yilmaz, I | 1 |
| Ulugol, A | 1 |
| Chaitoff, KA | 1 |
| Toner, F | 1 |
| Tedesco, A | 1 |
| Maher, TJ | 1 |
| Ally, A | 1 |
| Nawa, A | 1 |
| Fujita-Hamabe, W | 1 |
| Kishioka, S | 1 |
| Tokuyama, S | 1 |
| Doursout, MF | 1 |
| Liang, Y | 1 |
| Chelly, JE | 1 |
| Dudhgaonkar, SP | 2 |
| Kumar, D | 2 |
| Naik, A | 1 |
| Devi, AR | 1 |
| Bawankule, DU | 1 |
| Tandan, SK | 2 |
| Abdel-Zaher, AO | 1 |
| Hamdy, MM | 1 |
| Aly, SA | 1 |
| Abdel-Hady, RH | 1 |
| Abdel-Rahman, S | 1 |
| Joharchi, K | 1 |
| Jorjani, M | 1 |
| Arunadevi, R | 1 |
| Prakash, VR | 1 |
| Grover, VS | 1 |
| Sharma, A | 1 |
| Singh, M | 1 |
| da S Rocha, JC | 1 |
| Peixoto, ME | 1 |
| Jancar, S | 1 |
| de Q Cunha, F | 1 |
| de A Ribeiro, R | 1 |
| da Rocha, FA | 1 |
Other Studies
11 other studies available for pimagedine and Pain
| Article | Year |
|---|---|
Evidence for the involvement of TNF-α, IL-1β and IL-10 in the antinociceptive and anti-inflammatory effects of indole-3-guanylhydrazone hydrochloride, an aromatic aminoguanidine, in rodents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Behavior, Animal; Carrageenan; Guanidin | 2018 |
The effect of nitric oxide synthase inhibitors on the development of analgesic tolerance to dipyrone in mice.
Topics: Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Drug T | 2009 |
Effects of inducible nitric oxide synthase blockade within the periaqueductal gray on cardiovascular responses during mechanical, heat, and cold nociception.
Topics: Animals; Blood Pressure; Cold Temperature; Enzyme Inhibitors; Female; gamma-Aminobutyric Acid; Gluta | 2012 |
Decreased expression of intestinal P-glycoprotein increases the analgesic effects of oral morphine in a streptozotocin-induced diabetic mouse model.
Topics: Administration, Oral; Analgesics; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; | 2011 |
NOS inhibitors exhibit antinociceptive properties in the rat formalin test.
Topics: Analgesics; Animals; Arginine; Blood Pressure; Enzyme Inhibitors; Formaldehyde; Guanidines; Heart Ra | 2003 |
Interaction of inducible nitric oxide synthase and cyclooxygenase-2 inhibitors in formalin-induced nociception in mice.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Rel | 2004 |
Attenuation of morphine tolerance and dependence by aminoguanidine in mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Arginine; Behavior, Animal; Brain; Dizocilpine Maleate; Dru | 2006 |
The role of nitric oxide in diabetes-induced changes of morphine tolerance in rats.
Topics: Analgesics, Opioid; Animals; Arginine; Diabetes Mellitus, Experimental; Drug Tolerance; Guanidines; | 2007 |
Synergistic interaction between meloxicam and aminoguanidine in formalin-induced nociception in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Drug Evaluation, Prec | 2008 |
Role of nitric oxide in diabetes-induced attenuation of antinociceptive effect of morphine in mice.
Topics: Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Female; Guanidines; Male; Mice; Morphi | 2000 |
Dual effect of nitric oxide in articular inflammatory pain in zymosan-induced arthritis in rats.
Topics: Amidines; Animals; Arthritis, Experimental; Benzylamines; Cartilage, Articular; Dinoprost; Edema; En | 2002 |