Cathepsin L2

A cathepsin L2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60911]

Synonyms

EC 3.4.22.43;
Cathepsin U;
Cathepsin V

Research

Bioassay Publications (9)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (33.33)	29.6817
2010's	6 (66.67)	24.3611
2020's	0 (0.00)	2.80

Compounds (14)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
2-phenyl-4-oxohydroquinoline	Homo sapiens (human)	IC50	4.7000	1	1
6-methoxy-2-(4-methoxyphenyl)-1-benzopyran-4-one	Homo sapiens (human)	IC50	12.0000	1	1
6,2',4'-trimethoxyflavone	Homo sapiens (human)	IC50	50.0000	1	1
telaprevir	Homo sapiens (human)	IC50	1.3500	1	1
11-hydroxynoracronycine	Homo sapiens (human)	IC50	48.0000	1	1
citrusinine i	Homo sapiens (human)	IC50	2.2000	1	1
citrusinine i	Homo sapiens (human)	Ki	1.0000	1	1
relacatib	Homo sapiens (human)	Ki	0.0033	2	7
odanacatib	Homo sapiens (human)	IC50	0.7620	1	1
n-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide	Homo sapiens (human)	IC50	0.0750	1	1
mk-7009	Homo sapiens (human)	IC50	10.0000	1	1
gallinamide a	Homo sapiens (human)	IC50	0.3000	2	2
6-(3,5-difluoroanilino)-9-ethyl-2-purinecarbonitrile	Homo sapiens (human)	IC50	0.2399	1	1
9-(3,5-difluorophenyl)-6-(ethylamino)-2-purinecarbonitrile	Homo sapiens (human)	IC50	70.7946	1	1
grassystatin a	Homo sapiens (human)	IC50	10.0000	1	1

Enables

This protein enables 5 target(s):

Target	Category	Definition
cysteine-type endopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]
serine-type endopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
cysteine-type peptidase activity	molecular function	Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
cysteine-type endopeptidase activator activity involved in apoptotic process	molecular function	Binds to and increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process. [GOC:mah, GOC:mtg_apoptosis]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
lysosomal lumen	cellular component	The volume enclosed within the lysosomal membrane. [GOC:jl, PMID:15213228]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
lysosome	cellular component	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]

Involved In

This protein is involved in 7 target(s):

Target	Category	Definition
apoptotic process	biological process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
antigen processing and presentation of exogenous peptide antigen via MHC class II	biological process	The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. [GOC:add, ISBN:0781735149, PMID:15771591]
extracellular matrix disassembly	biological process	A process that results in the breakdown of the extracellular matrix. [GOC:jid]
immune response	biological process	Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. [GO_REF:0000022, GOC:add]
positive regulation of apoptotic signaling pathway	biological process	Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway. [GOC:mtg_apoptosis]
positive regulation of peptidase activity	biological process	Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. [GOC:dph, GOC:tb]
proteolysis involved in protein catabolic process	biological process	The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. [GOC:ai, GOC:dph, GOC:tb]