1-(3-chlorophenyl)piperazine has been researched along with Pain in 10 studies
1-(3-chlorophenyl)piperazine: supposed metabolite of TRAZODONE; RN given refers to parent cpd; structure
1-(3-chlorophenyl)piperazine : A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In a randomized, double-blind crossover study, we compared single doses of two 5-HT1 agonists, buspirone and m-chlorophenylpiperazine, to placebo in 20 patients with post-herpetic neuralgia or painful neuropathy." | 9.06 | Single doses of the serotonin agonists buspirone and m-chlorophenylpiperazine do not relieve neuropathic pain. ( Kishore-Kumar, R; Lawlor, BA; Max, MB; Murphy, DL; Schafer, SC, 1989) |
| " In a randomized, double-blind crossover study, we compared single doses of two 5-HT1 agonists, buspirone and m-chlorophenylpiperazine, to placebo in 20 patients with post-herpetic neuralgia or painful neuropathy." | 5.06 | Single doses of the serotonin agonists buspirone and m-chlorophenylpiperazine do not relieve neuropathic pain. ( Kishore-Kumar, R; Lawlor, BA; Max, MB; Murphy, DL; Schafer, SC, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 7 (70.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Obata, H | 1 |
| Ito, N | 1 |
| Sasaki, M | 1 |
| Saito, S | 1 |
| Goto, F | 1 |
| Rochat, C | 1 |
| Cervo, L | 1 |
| Romandini, S | 1 |
| Samanin, R | 1 |
| Sawynok, J | 1 |
| Reid, A | 1 |
| Sanchez, A | 1 |
| Niedbala, B | 1 |
| Feria, M | 1 |
| Mamede Rosa, ML | 1 |
| Prado, WA | 1 |
| Eide, PK | 2 |
| Joly, NM | 1 |
| Hole, K | 1 |
| Pascual, J | 1 |
| Max, MB | 2 |
| Kishore-Kumar, R | 2 |
| Lawlor, BA | 2 |
| Murphy, DL | 2 |
| Schafer, SC | 1 |
1 trial available for 1-(3-chlorophenyl)piperazine and Pain
| Article | Year |
|---|---|
Single doses of the serotonin agonists buspirone and m-chlorophenylpiperazine do not relieve neuropathic pain.
Topics: Adult; Aged; Buspirone; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle | 1989 |
9 other studies available for 1-(3-chlorophenyl)piperazine and Pain
| Article | Year |
|---|---|
Possible involvement of spinal noradrenergic mechanisms in the antiallodynic effect of intrathecally administered 5-HT2C receptor agonists in the rats with peripheral nerve injury.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Atropine; Injections, Spinal; Ligation; Male; Musc | 2007 |
Evidence that m-chlorophenylpiperazine inhibits some nociceptive responses of rats by activating 5-hydroxytryptamine mechanisms.
Topics: Animals; Male; Metergoline; Pain; Piperazines; Rats; Reaction Time; Serotonin; Time Factors | 1982 |
Spinal supersensitivity to 5-HT1, 5-HT2 and 5-HT3 receptor agonists following 5,7-dihydroxytryptamine.
Topics: 5,7-Dihydroxytryptamine; Amphetamines; Analgesia; Analgesics; Analysis of Variance; Animals; Binding | 1994 |
Modulation of neuropathic pain in rats by intrathecally injected serotonergic agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Injections, Spinal; Male; Pain; Piperazines; Rats; | 1995 |
Antinociception induced by opioid or 5-HT agonists microinjected into the anterior pretectal nucleus of the rat.
Topics: Analgesics; Animals; Benzomorphans; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine- | 1997 |
Stimulation of 5-HT1 receptors in the spinal cord changes substance P-induced behaviour.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Analgesia; Animals; Indoles; Injections, Spina | 1992 |
The role of spinal cord 5-HT1A and 5-HT1B receptors in the modulation of a spinal nociceptive reflex.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Indoles; Injections, Spinal; Male; Methoxydimethylt | 1990 |
Serotonin, serotonin receptors, serotonin receptor subtype agonists and pain.
Topics: Analgesics; Brain; Buspirone; Humans; Pain; Piperazines; Receptors, Serotonin; Serotonin | 1990 |
Response to Julio Pascual regarding Kishore-Kumar et al. (Pain, 37 (1989) 223-227)
Topics: Analgesics; Buspirone; Humans; Pain; Piperazines; Serotonin | 1990 |