Compounds > taspine
Page last updated: 2024-12-08

taspine

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Description

taspine: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID215159
CHEMBL ID470867
SCHEMBL ID22452213
MeSH IDM0069866

Synonyms (28)

Synonym
unii-v53xn9l07o
v53xn9l07o ,
(1)benzopyrano(5,4,3-cde)(1)benzopyran-5,10-dione, 1-(2-(dimethylamino)ethyl)-3,8-dimethoxy-
602-07-3
nsc688259
NCI60_031857
NCI60_041671
nsc618155
NSC76022 ,
2-dimethylaminoethyl(dimethoxy)[?]dione
thaspine
1-(2-(dimethylamino)ethyl)-3,8-dimethoxychromeno[5,4,3-cde]chromene-5,10-dione
nsc-76022
nsc-688259
taspine
bdbm50241808
{1-(2-dimethylaminoethyl)-3,8-dimethoxychromeno[5,4,3-cde]chromene-5,10-dione}
CHEMBL470867 ,
1-[2-(dimethylamino)ethyl]-3,8-dimethoxy-[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione
taspin
1-(2-(dimethylamino)ethyl)-3,8-dimethoxychromeno(5,4,3-cde)chromene-5,10-dione hydrochloride
FT-0674816
AKOS027326755
Q5486808
DTXSID60975624
SCHEMBL22452213
5-[2-(dimethylamino)ethyl]-7,14-dimethoxy-2,9-dioxatetracyclo[6.6.2.04,16.011,15]hexadeca-1(14),4(16),5,7,11(15),12-hexaene-3,10-dione
HY-131502

Research Excerpts

Overview

Taspine is an active component isolated from Radix et Rhizoma Leonticis with inhibiting tumor angiogenic properties. Taspine has many potent pharmacological effects.

ExcerptReferenceRelevance
"Taspine is an active compound in anticancer agent development. "( Novel taspine derivative 12k inhibits cell growth and induces apoptosis in lung cell carcinoma.
Dai, B; Liu, R; Wang, H; Wang, W; Zhang, Y, 2015)		2.34
"Taspine is an active component isolated from Radix et Rhizoma Leonticis with inhibiting tumor angiogenic properties. "( Taspine downregulates VEGF expression and inhibits proliferation of vascular endothelial cells through PI3 kinase and MAP kinase signaling pathways.
Chen, W; He, L; Li, X; Zhao, J; Zhao, L, )		3.02
"Taspine is a bioactive aporphine alkaloid, which has many potent pharmacological effects. "( HPLC method for the pharmacokinetics and tissue distribution of taspine solution and taspine liposome after intravenous administrations to mice.
He, LC; Lu, W; Zeng, XM, 2008)		2.03

Effects

Taspine has shown meaningful angiogenesis activity in previous studies. It has antitumor effect on the S180 sarcoma. The mechanism may be through the way of decreasing the expressing of the VEGF, bFGF, Bcl-2 and Bax.

ExcerptReferenceRelevance
"Taspine has been indicated to be a potential anti‑carcinogenic agent. "( Taspine derivative TAS9 regulates cell growth and metastasis of human hepatocellular carcinoma.
Dai, B; Liu, R; Liu, Y; Wang, W; Zhang, Y, 2015)		3.3
"Taspine has shown meaningful angiogenesis activity in previous studies."( Antitumor activity of taspine by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo.
Chen, Y; Dai, B; He, L; Wang, N; Zhang, J; Zhang, Y; Zheng, L, 2011)		1.41
"Taspine has antitumor effect on the S180 sarcoma, and the mechanism may be through the way of decreasing the expressing of the VEGF, bFGF, Bcl-2 and Bax and inducing the vascular endothelial cell apoptosis."( [Inhibitory effect of taspine on mouse S180 sarcoma and its mechanism].
He, LC; Wang, HY; Zhang, YM, 2007)		2.1
"Taspine has been isolated as a cytotoxic substance from Sangre de Grado, sap of Croton palanostigma (Euphorbiaceae), by bioassay guided fractionation. "( A cytotoxic substance from Sangre de Grado.
Enomori, T; Ichihara, Y; Inamatsu, M; Itokawa, H; Mochizuki, M; Morita, H; Shirota, O; Takeya, K, 1991)		1.72

Pharmacokinetics

ExcerptReferenceRelevance
" In contrast, the total body clearance (CL), apparent volume of distribution V(c) and plasma half-life for the distribution (t(1/2 alpha)) and elimination phase (t(1/2 beta)) were lower for L-Ta, in comparison to the respective parameter of Ta."( HPLC method for the pharmacokinetics and tissue distribution of taspine solution and taspine liposome after intravenous administrations to mice.
He, LC; Lu, W; Zeng, XM, 2008)		0.58
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
AcetylcholinesteraseElectrophorus electricus (electric eel)IC50 (µMol)0.33000.00000.94539.9400AID378482
AcetylcholinesteraseHomo sapiens (human)IC50 (µMol)0.54000.00000.933210.0000AID378483
CholinesteraseEquus caballus (horse)IC50 (µMol)100.00000.00002.22149.4000AID378484
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (14)

Processvia Protein(s)Taxonomy
acetylcholine catabolic process in synaptic cleftAcetylcholinesteraseHomo sapiens (human)
regulation of receptor recyclingAcetylcholinesteraseHomo sapiens (human)
osteoblast developmentAcetylcholinesteraseHomo sapiens (human)
acetylcholine catabolic processAcetylcholinesteraseHomo sapiens (human)
cell adhesionAcetylcholinesteraseHomo sapiens (human)
nervous system developmentAcetylcholinesteraseHomo sapiens (human)
synapse assemblyAcetylcholinesteraseHomo sapiens (human)
receptor internalizationAcetylcholinesteraseHomo sapiens (human)
negative regulation of synaptic transmission, cholinergicAcetylcholinesteraseHomo sapiens (human)
amyloid precursor protein metabolic processAcetylcholinesteraseHomo sapiens (human)
positive regulation of protein secretionAcetylcholinesteraseHomo sapiens (human)
retina development in camera-type eyeAcetylcholinesteraseHomo sapiens (human)
acetylcholine receptor signaling pathwayAcetylcholinesteraseHomo sapiens (human)
positive regulation of cold-induced thermogenesisAcetylcholinesteraseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (10)

Processvia Protein(s)Taxonomy
amyloid-beta bindingAcetylcholinesteraseHomo sapiens (human)
acetylcholinesterase activityAcetylcholinesteraseHomo sapiens (human)
cholinesterase activityAcetylcholinesteraseHomo sapiens (human)
protein bindingAcetylcholinesteraseHomo sapiens (human)
collagen bindingAcetylcholinesteraseHomo sapiens (human)
hydrolase activityAcetylcholinesteraseHomo sapiens (human)
serine hydrolase activityAcetylcholinesteraseHomo sapiens (human)
acetylcholine bindingAcetylcholinesteraseHomo sapiens (human)
protein homodimerization activityAcetylcholinesteraseHomo sapiens (human)
laminin bindingAcetylcholinesteraseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (13)

Processvia Protein(s)Taxonomy
extracellular regionAcetylcholinesteraseHomo sapiens (human)
basement membraneAcetylcholinesteraseHomo sapiens (human)
extracellular spaceAcetylcholinesteraseHomo sapiens (human)
nucleusAcetylcholinesteraseHomo sapiens (human)
Golgi apparatusAcetylcholinesteraseHomo sapiens (human)
plasma membraneAcetylcholinesteraseHomo sapiens (human)
cell surfaceAcetylcholinesteraseHomo sapiens (human)
membraneAcetylcholinesteraseHomo sapiens (human)
neuromuscular junctionAcetylcholinesteraseHomo sapiens (human)
synaptic cleftAcetylcholinesteraseHomo sapiens (human)
synapseAcetylcholinesteraseHomo sapiens (human)
perinuclear region of cytoplasmAcetylcholinesteraseHomo sapiens (human)
side of membraneAcetylcholinesteraseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (33)

Assay IDTitleYearJournalArticle
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
AID489612Antiproliferative activity against human ECV304 cells after 48 hrs by MTT assay2010European journal of medicinal chemistry, Jul, Volume: 45, Issue:7
Synthesis and preliminary biological evaluation of novel taspine derivatives as anticancer agents.
AID658162Stabilization of human G-quadruplex F21T assessed as change in melting temperature at 1 uM by FRET assay2012Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8
Identification of novel telomeric G-quadruplex-targeting chemical scaffolds through screening of three NCI libraries.
AID358269Cicatrizant activity in mouse assessed as wound healing by tensile strength method2001Journal of natural products, Oct, Volume: 64, Issue:10
(+)-epi-Alpha-bisabolol [correction of bisbolol] is the wound-healing principle of Peperomia galioides: investigation of the in vivo wound-healing activity of related terpenoids.
AID338856Cytotoxicity against HUVEC cell at 5 ug/ml after 6 days1993Journal of natural products, Jun, Volume: 56, Issue:6
Isolation of a dihydrobenzofuran lignan from South American dragon's blood (Croton spp.) as an inhibitor of cell proliferation.
AID377155Embryotoxicity in rat embryo at 5 ug/mL1999Journal of natural products, Oct, Volume: 62, Issue:10
Detecting potential teratogenic alkaloids from blue cohosh rhizomes using an in vitro rat embryo culture.
AID658164Stabilization of human G-quadruplex F21T assessed as change in melting temperature at 5 uM by FRET assay2012Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8
Identification of novel telomeric G-quadruplex-targeting chemical scaffolds through screening of three NCI libraries.
AID377165Embryotoxicity in rat embryo at 250 ug/mL1999Journal of natural products, Oct, Volume: 62, Issue:10
Detecting potential teratogenic alkaloids from blue cohosh rhizomes using an in vitro rat embryo culture.
AID489613Antiproliferative activity against human HEK293 cells overexpressing EGFR after 48 hrs by MTT assay2010European journal of medicinal chemistry, Jul, Volume: 45, Issue:7
Synthesis and preliminary biological evaluation of novel taspine derivatives as anticancer agents.
AID658163Stabilization of DNA duplex hairpin structure assessed as change in melting temperature at 1 uM by FRET assay2012Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8
Identification of novel telomeric G-quadruplex-targeting chemical scaffolds through screening of three NCI libraries.
AID377158Teratogenic activity in rat embryo assessed as incidence of major malformation at 5 ug/mL after 45 hrs relative to control1999Journal of natural products, Oct, Volume: 62, Issue:10
Detecting potential teratogenic alkaloids from blue cohosh rhizomes using an in vitro rat embryo culture.
AID378482Inhibition of electric eel AChE by Ellman's assay2006Journal of natural products, Sep, Volume: 69, Issue:9
Taspine: bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana.
AID338857Cytotoxicity against HUVEC cell at 2.5 ug/ml after 6 days1993Journal of natural products, Jun, Volume: 56, Issue:6
Isolation of a dihydrobenzofuran lignan from South American dragon's blood (Croton spp.) as an inhibitor of cell proliferation.
AID377149Teratogenic activity in rat embryo assessed as incidence of major malformation at 1.25 ug/mL after 45 hrs relative to control1999Journal of natural products, Oct, Volume: 62, Issue:10
Detecting potential teratogenic alkaloids from blue cohosh rhizomes using an in vitro rat embryo culture.
AID455670Lipophilicity, log D at pH 7.42010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
Discovery of novel taspine derivatives as antiangiogenic agents.
AID377154Effect on growth and morphogenesis of organogenesis-staged rat embryo at 50 ug/mL after 45 hrs relative to control1999Journal of natural products, Oct, Volume: 62, Issue:10
Detecting potential teratogenic alkaloids from blue cohosh rhizomes using an in vitro rat embryo culture.
AID455674Antiproliferative activity against human A549 cells2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
Discovery of novel taspine derivatives as antiangiogenic agents.
AID455672Solubility at pH 7.42010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
Discovery of novel taspine derivatives as antiangiogenic agents.
AID455671Dissociation constant, pKa of the compound2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
Discovery of novel taspine derivatives as antiangiogenic agents.
AID377164Embryotoxicity in rat embryo at 80 ug/mL1999Journal of natural products, Oct, Volume: 62, Issue:10
Detecting potential teratogenic alkaloids from blue cohosh rhizomes using an in vitro rat embryo culture.
AID455675Antiproliferative activity against human Caco-2 cells2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
Discovery of novel taspine derivatives as antiangiogenic agents.
AID455676Antiproliferative activity against human ECV304 cells2010Bioorganic & medicinal chemistry letters, Jan-15, Volume: 20, Issue:2
Discovery of novel taspine derivatives as antiangiogenic agents.
AID338855Cytotoxicity against HUVEC cell at 25 ug/ml after 6 days1993Journal of natural products, Jun, Volume: 56, Issue:6
Isolation of a dihydrobenzofuran lignan from South American dragon's blood (Croton spp.) as an inhibitor of cell proliferation.
AID489614Antiproliferative activity against human A431 cells abnormally expressing EGFR after 48 hrs by MTT assay2010European journal of medicinal chemistry, Jul, Volume: 45, Issue:7
Synthesis and preliminary biological evaluation of novel taspine derivatives as anticancer agents.
AID378483Inhibition of human AChE by Ellman's assay2006Journal of natural products, Sep, Volume: 69, Issue:9
Taspine: bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana.
AID489610Antiproliferative activity against human Caco-2 cells after 48 hrs by MTT assay2010European journal of medicinal chemistry, Jul, Volume: 45, Issue:7
Synthesis and preliminary biological evaluation of novel taspine derivatives as anticancer agents.
AID378484Inhibition of horse serum BuChE by Ellman's method2006Journal of natural products, Sep, Volume: 69, Issue:9
Taspine: bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana.
AID338859Induction of HUVEC cell proliferation at 0.25 ug/ml after 6 days1993Journal of natural products, Jun, Volume: 56, Issue:6
Isolation of a dihydrobenzofuran lignan from South American dragon's blood (Croton spp.) as an inhibitor of cell proliferation.
AID377151Effect on growth and morphogenesis of organogenesis-staged rat embryo at 1.25 ug/mL after 45 hrs relative to control1999Journal of natural products, Oct, Volume: 62, Issue:10
Detecting potential teratogenic alkaloids from blue cohosh rhizomes using an in vitro rat embryo culture.
AID377163Embryotoxicity in rat embryo at 20 ug/mL1999Journal of natural products, Oct, Volume: 62, Issue:10
Detecting potential teratogenic alkaloids from blue cohosh rhizomes using an in vitro rat embryo culture.
AID489611Antiproliferative activity against human A549 cells after 48 hrs by MTT assay2010European journal of medicinal chemistry, Jul, Volume: 45, Issue:7
Synthesis and preliminary biological evaluation of novel taspine derivatives as anticancer agents.
AID377150Effect on growth and morphogenesis of organogenesis-staged rat embryo at 0.1 ug/mL after 45 hrs relative to control1999Journal of natural products, Oct, Volume: 62, Issue:10
Detecting potential teratogenic alkaloids from blue cohosh rhizomes using an in vitro rat embryo culture.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (47)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (4.26)18.7374
1990's4 (8.51)18.2507
2000's10 (21.28)29.6817
2010's27 (57.45)24.3611
2020's4 (8.51)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.75

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index27.75 (24.57)
Research Supply Index3.95 (2.92)
Research Growth Index5.10 (4.65)
Search Engine Demand Index32.40 (26.88)
Search Engine Supply Index2.17 (0.95)

This Compound (27.75)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other51 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
acetic acid
Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed). acetic acid : A simple monocarboxylic acid containing two carbons.		2.1310monocarboxylic acidantimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent
niacinamide
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.		2.0710pyridine alkaloid;
pyridinecarboxamide;
vitamin B3		anti-inflammatory agent;
antioxidant;
cofactor;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
Escherichia coli metabolite;
geroprotector;
human urinary metabolite;
metabolite;
mouse metabolite;
neuroprotective agent;
Saccharomyces cerevisiae metabolite;
Sir2 inhibitor
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		7.4110isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
tacrine
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.. tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.		2.0310acridines;
aromatic amine		EC 3.1.1.7 (acetylcholinesterase) inhibitor
thymidine
[no description available]		2.3820pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
tolonium chloride
Tolonium Chloride: A phenothiazine that has been used as a hemostatic, a biological stain, and a dye for wool and silk. Tolonium chloride has also been used as a diagnostic aid for oral and gastric neoplasms and in the identification of the parathyroid gland in thyroid surgery.. tolonium chloride : An organic chloride salt having 3-amino-7-(dimethylamino)-2-methylphenothiazin-5-ium (tolonium) as the counterion. It is a blue nuclear counterstain that can be used to demonstrate Nissl substance and is also useful for staining mast cell granules, both in metachromatic and orthochromatic techniques.		2.0710
diphenyl
diphenyl: RN given refers to unlabeled cpd; structure		2.5320aromatic fungicide;
benzenes;
biphenyls		antifungal agrochemical;
antimicrobial food preservative
catechin
Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.. catechin : Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.. rac-catechin : A racemate comprising equimolar amounts of (+)- and (-)-catechin. (+)-catechin : The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.		2.1310catechinantioxidant;
plant metabolite
quinazolines
Quinazolines: A group of aromatic heterocyclic compounds that contain a bicyclic structure with two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring.. quinazoline : A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.. quinazolines : Any organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives.		2.1710azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinazolines
galantamine
Galantamine: A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.. galanthamine : A benzazepine alkaloid isolated from certain species of daffodils.		2.0310benzazepine alkaloid fundamental parent;
benzazepine alkaloid;
organic heterotetracyclic compound;
tertiary amino compound		antidote to curare poisoning;
cholinergic drug;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
plant metabolite
dequalinium chloride
dequalinium chloride : An organic chloride salt that is the dichloride salt of dequalinium.		2.0710organic chloride saltantifungal agent;
antineoplastic agent;
antiseptic drug;
mitochondrial NADH:ubiquinone reductase inhibitor
Berberine chloride (TN)
[no description available]		2.0710organic molecular entity
tetradecanoylphorbol acetate
Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.		1.9810acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.0710taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
acodazole
[no description available]		2.0710
gallocatechol
gallocatechol: structure give in first source; RN given for (trans-(+-))-omer; inhibits DNA-dependent DNA & RNA polymerases. (+)-gallocatechin : A gallocatechin that has (2R,3S)-configuration. It is found in green tea and bananas.. gallocatechin : A catechin that is a flavan substituted by hydroxy groups at positions 3, 3', 4', 5, 5' and 7 (the trans isomer). It is isolated from Acacia mearnsii.		2.1310gallocatechinantioxidant;
metabolite;
radical scavenger
nsc 38280
[no description available]		2.0710
magnoflorine
magnoflorine: opium alkaloid having the aporphine configuration; RN given refers to parent cpd(S)-isomer; structure. (S)-magnoflorine : An aporphine alkaloid that is (S)-corytuberine in which the nitrogen has been quaternised by an additional methyl group.		7.7630aporphine alkaloid;
quaternary ammonium ion		plant metabolite
procyanidin
Proanthocyanidins: Dimers and oligomers of flavan-3-ol units (CATECHIN analogs) linked mainly through C4 to C8 bonds to leucoanthocyanidins. They are structurally similar to ANTHOCYANINS but are the result of a different fork in biosynthetic pathways.		2.1310proanthocyanidin
gefitinib
[no description available]		2.0510aromatic ether;
monochlorobenzenes;
monofluorobenzenes;
morpholines;
quinazolines;
secondary amino compound;
tertiary amino compound		antineoplastic agent;
epidermal growth factor receptor antagonist
procyanidin b3
procyanidin B3 : A proanthocyanidin consisting of two molecules of (+)-catechin joined by a bond between positions 4 and 8' in alpha-configuration. It can be found in red wine, in barley, in beer, in peach or in Jatropha macrantha, the Huanarpo Macho.		2.1310biflavonoid;
hydroxyflavan;
polyphenol;
proanthocyanidin		anti-inflammatory agent;
antioxidant;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
metabolite
asimilobine
asimilobine: from Nelumbro nucifera; RN given refers to (R)-isomer		2.0310aporphine alkaloidmetabolite
hardwickic acid
hardwickic acid: structure given in first source; isolated from the roots of Croton sonderianus; RN given for (+)-isomer		2.1310
sorafenib
[no description available]		2.0710(trifluoromethyl)benzenes;
aromatic ether;
monochlorobenzenes;
phenylureas;
pyridinecarboxamide		angiogenesis inhibitor;
anticoronaviral agent;
antineoplastic agent;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
ferroptosis inducer;
tyrosine kinase inhibitor
benzofurans
Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.		1.9810
nsc 314622
NSC 314622: structure in first source		2.0710
bisabolol
Kamillosan: drug combination containing chamomile and bisabolol; used to treat dermatitis		210sesquiterpenoid
1-alpha-terpineol
(S)-(-)-alpha-terpineol : The (S)-enantiomer of alpha-terpineol.		210alpha-terpineolplant metabolite
n-formylmethionine leucyl-phenylalanine
N-Formylmethionine Leucyl-Phenylalanine: A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them to release lysosomal enzymes and become metabolically activated.. N-formyl-L-methionyl-L-leucyl-L-phenylalanine : A tripeptide composed of L-Met, L-Leu and L-Phe in a linear sequence with a formyl group at the amino terminus. It acts as a potent inducer of leucocyte chemotaxis and macrophage activator as well as a ligand for the FPR receptor.		1.9810tripeptide
farnesol
Farnesol: A colorless liquid extracted from oils of plants such as citronella, neroli, cyclamen, and tuberose. It is an intermediate step in the biological synthesis of cholesterol from mevalonic acid in vertebrates. It has a delicate odor and is used in perfumery. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed). (2-trans,6-trans)-farnesol : The (2-trans,6-trans)-stereoisomer of farnesol.. farnesol : A farnesane sesquiterpenoid that is dodeca-2,6,10-triene substituted by methyl groups at positions 3, 7 and 11 and a hydroxy group at position 1.		210farnesolplant metabolite
nerolidol
(6E)-nerolidol : A nerolidol in which the double bond at position 6 adopts a trans-configuration.		210nerolidol
braco-19
BRACO-19: structure in first source		2.0710acridines;
N-alkylpyrrolidine
nk 5
NK 5: antioxidant containing divalent cations of iron, manganese, & cobalt		2.0710organic iodide salt;
quinolines		fluorochrome
epidermal growth factor
Epidermal Growth Factor: A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.		3.1550
transforming growth factor beta
Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.		2.0210
cyclin d1
Cyclin D1: Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.		2.0610
ConditionIndicatedRelationship StrengthStudiesTrials
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.3920
Plasmodium falciparum Malaria
[description not available]		02.110
Malaria, Falciparum
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.		02.110
Breast Cancer
[description not available]		02.5520
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.5520
Injuries
Used with anatomic headings, animals, and sports for wounds and injuries. Excludes cell damage, for which pathology is used.		02.7230
Wounds and Injuries
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.		02.7230
Carcinoma, Non-Small Cell Lung
[description not available]		02.520
Cancer of Lung
[description not available]		02.5720
Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.		02.520
Lung Neoplasms
Tumors or cancer of the LUNG.		02.5720
Benign Neoplasms
[description not available]		02.5220
Angiogenesis, Pathologic
[description not available]		02.7930
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.5220
Cancer of Cervix
[description not available]		02.2110
Uterine Cervical Neoplasms
Tumors or cancer of the UTERINE CERVIX.		02.2110
Hepatocellular Carcinoma
[description not available]		07.7730
Cancer of Liver
[description not available]		02.7730
Invasiveness, Neoplasm
[description not available]		02.1110
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.7730
Liver Neoplasms
Tumors or cancer of the LIVER.		02.7730
Anasarca
[description not available]		02.420
Ache
[description not available]		02.1310
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		02.420
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.		02.1310
Carcinoma, Anaplastic
[description not available]		02.0510
Cancer of Colon
[description not available]		02.7630
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		02.0510
Colonic Neoplasms
Tumors or cancer of the COLON.		02.7630
Malignant Melanoma
[description not available]		02.0710
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		07.0710
Sarcoma 180
An experimental sarcoma of mice.		02.0310
Innate Inflammatory Response
[description not available]		01.9810
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		01.9810
Adjuvant Arthritis
[description not available]		01.9510
Granulomas
[description not available]		01.9510
Granuloma
A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.		01.9510