| Substance | Description | Relationhip Strength | Studies | Trials | Classes | Roles |
|---|
| clonidine | [no description available] | medium | 66 | 0 | clonidine;
imidazoline | |
| clonidine | [no description available] | medium | 66 | 1 | clonidine;
imidazoline | |
| 2-(2-methyl-4-chlorophenylamino)-2-imidazoline | [no description available] | medium | 3 | 0 | | |
| xylonidine | [no description available] | medium | 3 | 0 | | |
| imidazole | [no description available] | medium | 1 | 0 | imidazole | |
| 1-methylimidazole | [no description available] | medium | 1 | 0 | imidazoles | |
| azomycin | [no description available] | medium | 1 | 0 | C-nitro compound;
imidazoles | antitubercular agent |
| 2-methylimidazole | [no description available] | medium | 1 | 0 | | |
| 1-methyl-2-nitroimidazole | [no description available] | medium | 1 | 0 | | |
| 2-ethylimidazole | [no description available] | medium | 1 | 0 | | |
| 2-phenylimidazole | [no description available] | medium | 1 | 0 | | |
| 2-aminoimidazole | [no description available] | medium | 1 | 0 | | |
| octopamine | [no description available] | medium | 1 | 0 | phenylethanolamines;
tyramines | neurotransmitter |
| nc 5z | [no description available] | medium | 1 | 0 | | |
| 4-hydroxybenzoic acid | [no description available] | medium | 1 | 0 | monohydroxybenzoic acid | algal metabolite;
plant metabolite |
| benzoic acid | [no description available] | medium | 1 | 0 | benzoic acids | algal metabolite;
antimicrobial food preservative;
drug allergen;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
human xenobiotic metabolite;
plant metabolite |
| 3-chlorobenzoic acid | [no description available] | medium | 1 | 0 | monochlorobenzoic acid | drug metabolite |
| 4-aminobenzoic acid | [no description available] | medium | 1 | 0 | aminobenzoic acid;
aromatic amino-acid zwitterion | allergen;
Escherichia coli metabolite;
plant metabolite |
| 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | [no description available] | medium | 1 | 0 | methylpyridines;
phenylpyridine;
tetrahydropyridine | neurotoxin |
| corticosterone | [no description available] | medium | 1 | 0 | 11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone | human metabolite;
mouse metabolite |
| etiocholanolone | [no description available] | medium | 1 | 0 | 17-oxo steroid;
3alpha-hydroxy steroid;
androstanoid | human metabolite;
mouse metabolite |
| dehydroepiandrosterone | [no description available] | medium | 1 | 0 | 17-oxo steroid;
3beta-hydroxy-Delta(5)-steroid;
androstanoid | androgen;
human metabolite;
mouse metabolite |
| 4-nitrobenzoic acid | [no description available] | medium | 1 | 0 | nitrobenzoic acid | |
| androstenedione | [no description available] | medium | 1 | 0 | 17-oxo steroid;
3-oxo-Delta(4) steroid;
androstanoid | androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite |
| desoxycorticosterone | [no description available] | medium | 1 | 0 | 20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
mineralocorticoid;
primary alpha-hydroxy ketone | human metabolite;
mouse metabolite |
| 17-alpha-hydroxyprogesterone | [no description available] | medium | 1 | 0 | 17alpha-hydroxy-C21-steroid;
17alpha-hydroxy steroid;
tertiary alpha-hydroxy ketone | human metabolite;
metabolite;
mouse metabolite;
progestin |
| 4-chlorobenzoic acid | [no description available] | medium | 1 | 0 | monochlorobenzoic acid | bacterial xenobiotic metabolite |
| 4-tert-butylbenzoic acid | [no description available] | medium | 1 | 0 | alkylbenzene | |
| 3-toluic acid | [no description available] | medium | 1 | 0 | methylbenzoic acid | human xenobiotic metabolite |
| 3-aminobenzoic acid | [no description available] | medium | 1 | 0 | aminobenzoic acid | |
| 3-hydroxybenzoic acid | [no description available] | medium | 1 | 0 | monohydroxybenzoic acid | bacterial metabolite;
plant metabolite |
| 4-toluic acid | [no description available] | medium | 1 | 0 | methylbenzoic acid | |
| 4-anisic acid | [no description available] | medium | 1 | 0 | methoxybenzoic acid | plant metabolite |
| 3-nitrobenzoic acid | [no description available] | medium | 1 | 0 | | |
| pregnenolone | [no description available] | medium | 1 | 0 | 20-oxo steroid;
3beta-hydroxy-Delta(5)-steroid;
C21-steroid | human metabolite;
mouse metabolite |
| 4-(trifluoromethyl)benzoic acid | [no description available] | medium | 1 | 0 | (trifluoromethyl)benzenes;
benzoic acids | |
| 3-fluorobenzoic acid | [no description available] | medium | 1 | 0 | fluorobenzoic acid | |
| 4-fluorobenzoic acid | [no description available] | medium | 1 | 0 | fluorobenzoic acid | bacterial xenobiotic metabolite |
| dihydrotestosterone | [no description available] | medium | 1 | 0 | 17beta-hydroxy steroid;
17beta-hydroxyandrostan-3-one;
3-oxo-5alpha-steroid | androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite |
| 3-methoxybenzoic acid | [no description available] | medium | 1 | 0 | methoxybenzoic acid | flavouring agent;
human urinary metabolite |
| 4-bromobenzoic acid | [no description available] | medium | 1 | 0 | bromobenzoic acid | |
| 3-iodobenzoate | [no description available] | medium | 1 | 0 | iodobenzoic acid | |
| 4-ethylbenzoic acid | [no description available] | medium | 1 | 0 | benzoic acids | |
| 4-cyanobenzoic acid | [no description available] | medium | 1 | 0 | | |
| norharman | [no description available] | medium | 1 | 0 | beta-carbolines;
mancude organic heterotricyclic parent | fungal metabolite;
marine metabolite |
| 4-(fluorosulfonyl)benzoic acid | [no description available] | medium | 1 | 0 | | |
| tiazuril | [no description available] | medium | 1 | 0 | aryl sulfide | |
| 1-methyl-4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine | [no description available] | medium | 1 | 0 | | |
| 4-phenyl-1,2,3,6-tetrahydropyridine | [no description available] | medium | 1 | 0 | | |
| 4-(methylthio)benzoic acid | [no description available] | medium | 1 | 0 | | |
| 17-alpha-hydroxypregnenolone | [no description available] | medium | 1 | 0 | 17alpha-hydroxy-C21-steroid;
17alpha-hydroxy steroid;
3beta-hydroxy-Delta(5)-steroid;
hydroxypregnenolone;
tertiary alpha-hydroxy ketone | human metabolite;
mouse metabolite |
| 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine | [no description available] | medium | 1 | 0 | | |
| 4-mercaptobenzoate | [no description available] | medium | 1 | 0 | | |
| 2,5-dihydro-2-(4-methoxyphenyl)-3h-pyrazolo(4,3-c)quinolin-3-one | [no description available] | medium | 1 | 0 | | |
| beta-carboline-3-carboxylic acid ethyl ester | [no description available] | medium | 1 | 0 | beta-carbolines | |
| beta-carboline-3-carboxylic acid methyl ester | [no description available] | medium | 1 | 0 | beta-carbolines | |
| 2-methyltryptoline | [no description available] | medium | 1 | 0 | beta-carbolines | |
| 3-ethoxy-beta-carboline | [no description available] | medium | 1 | 0 | | |
| tert-butyl beta-carboline-3-carboxylate | [no description available] | medium | 1 | 0 | | |
| 1-methyl-4-cyclohexyl-1,2,3,6-tetrahydropyridine | [no description available] | medium | 1 | 0 | | |
| 1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine | [no description available] | medium | 1 | 0 | | |
| 1-methyl-4-(methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine | [no description available] | medium | 1 | 0 | | |
| 4-benzyl-1-methyl-1,2,3,6-tetrahydropyridine | [no description available] | medium | 1 | 0 | | |
| n-propyl-4-phenyl-1,2,3,6-tetrahydropyridine | [no description available] | medium | 1 | 0 | | |
| cortisone | [no description available] | medium | 1 | 0 | 11-oxo steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone | human metabolite;
mouse metabolite |
| cortodoxone | [no description available] | medium | 1 | 0 | deoxycortisol;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone | human metabolite;
mouse metabolite |
| diclazuril | [no description available] | medium | 1 | 0 | nitrile | |
| 3-propoxy-beta-carboline | [no description available] | medium | 1 | 0 | | |
| harman | [no description available] | medium | 1 | 0 | harmala alkaloid;
indole alkaloid fundamental parent;
indole alkaloid | anti-HIV agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
plant metabolite |
| 1-Ethyl-9H-pyrido[3,4-b]indole | [no description available] | medium | 1 | 0 | harmala alkaloid | |
| acetic acid | [no description available] | medium | 1 | 0 | monocarboxylic acid | antimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent |
| imiloxan | [no description available] | medium | 2 | 0 | benzodioxine | |
| brl 44408 | [no description available] | medium | 1 | 0 | | |
| acridines | [no description available] | medium | 1 | 0 | acridines;
mancude organic heterotricyclic parent;
polycyclic heteroarene | genotoxin |
| jp-1302 | [no description available] | medium | 1 | 0 | | |
| substance p | [no description available] | medium | 3 | 0 | peptide | neurokinin-1 receptor agonist;
neurotransmitter;
vasodilator agent |
| formaldehyde | [no description available] | medium | 2 | 0 | aldehyde;
one-carbon compound | allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
| morphine | [no description available] | medium | 12 | 0 | morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound | anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic |
| dexmedetomidine | [no description available] | medium | 2 | 0 | medetomidine | alpha-adrenergic agonist;
analgesic;
non-narcotic analgesic;
sedative |
| rilmenidine | [no description available] | medium | 1 | 0 | isourea | |
| oxazoles | [no description available] | medium | 2 | 0 | 1,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene | |
| ag 3-5 | [no description available] | medium | 1 | 0 | C-nitro compound | |
| agmatine | [no description available] | medium | 1 | 0 | guanidines;
primary amino compound | Escherichia coli metabolite;
mouse metabolite |
| yohimbine | [no description available] | medium | 8 | 0 | methyl 17-hydroxy-20xi-yohimban-16-carboxylate | alpha-adrenergic antagonist;
dopamine receptor D2 antagonist;
serotonergic antagonist |
| pyrimidinones | [no description available] | medium | 1 | 0 | | |
| enkephalin, d-penicillamine (2,5)- | [no description available] | medium | 1 | 0 | heterodetic cyclic peptide | delta-opioid receptor agonist |
| u-50488 | [no description available] | medium | 2 | 0 | dichlorobenzene;
monocarboxylic acid amide;
N-alkylpyrrolidine | analgesic;
antitussive;
calcium channel blocker;
diuretic;
kappa-opioid receptor agonist |
| xylazine | [no description available] | medium | 3 | 0 | 1,3-thiazine;
methylbenzene;
secondary amino compound | alpha-adrenergic agonist;
analgesic;
emetic;
muscle relaxant;
sedative |
| prazosin | [no description available] | medium | 7 | 0 | aromatic ether;
furans;
monocarboxylic acid amide;
piperazines;
quinazolines | alpha-adrenergic antagonist;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor |
| phenylephrine | [no description available] | medium | 4 | 0 | phenols;
phenylethanolamines;
secondary amino compound | alpha-adrenergic agonist;
cardiotonic drug;
mydriatic agent;
nasal decongestant;
protective agent;
sympathomimetic agent;
vasoconstrictor agent |
| isoproterenol | [no description available] | medium | 2 | 0 | catechols;
secondary alcohol;
secondary amino compound | beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
sympathomimetic agent |
| terbutaline | [no description available] | medium | 2 | 0 | phenylethanolamines;
resorcinols | anti-asthmatic drug;
beta-adrenergic agonist;
bronchodilator agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
hypoglycemic agent;
sympathomimetic agent;
tocolytic agent |
| phentolamine | [no description available] | medium | 4 | 0 | imidazoles;
phenols;
substituted aniline;
tertiary amino compound | alpha-adrenergic antagonist;
vasodilator agent |
| baclofen | [no description available] | medium | 1 | 0 | amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid;
monochlorobenzenes;
primary amino compound | central nervous system depressant;
GABA agonist;
muscle relaxant |
| meperidine | [no description available] | medium | 1 | 0 | ethyl ester;
piperidinecarboxylate ester;
tertiary amino compound | antispasmodic drug;
kappa-opioid receptor agonist;
mu-opioid receptor agonist;
opioid analgesic |
| naloxone | [no description available] | medium | 7 | 0 | morphinane alkaloid;
organic heteropentacyclic compound;
tertiary alcohol | antidote to opioid poisoning;
central nervous system depressant;
mu-opioid receptor antagonist |
| deoxyglucose | [no description available] | medium | 1 | 0 | | |
| methacholine chloride | [no description available] | medium | 1 | 0 | quaternary ammonium salt | |
| pentagastrin | [no description available] | medium | 1 | 0 | organic molecular entity | |
| histamine | [no description available] | medium | 1 | 0 | aralkylamino compound;
imidazoles | human metabolite;
mouse metabolite;
neurotransmitter |
| methoxamine | [no description available] | medium | 2 | 0 | amphetamines | alpha-adrenergic agonist;
antihypotensive agent |
| oxidopamine | [no description available] | medium | 2 | 0 | benzenetriol;
catecholamine;
primary amino compound | drug metabolite;
human metabolite;
neurotoxin |
| quinazolines | [no description available] | medium | 2 | 0 | azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinazolines | |
| tolazoline | [no description available] | medium | 1 | 0 | imidazoles | alpha-adrenergic antagonist;
antihypertensive agent;
vasodilator agent |
| naphazoline | [no description available] | medium | 2 | 0 | naphthalenes | |
| tiamenidine | [no description available] | medium | 1 | 0 | organochlorine compound | |
| flutonidine | [no description available] | medium | 2 | 0 | | |
| guanfacine | [no description available] | medium | 2 | 0 | acetamides | |
| guanabenz | [no description available] | medium | 1 | 0 | dichlorobenzene | |
| indoramin | [no description available] | medium | 1 | 0 | tryptamines | |
| lofexidine | [no description available] | medium | 1 | 0 | aromatic ether;
carboxamidine;
dichlorobenzene;
imidazoles | alpha-adrenergic agonist;
antihypertensive agent |
| thiophenes | [no description available] | medium | 1 | 0 | mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound | non-polar solvent |
| piperoxan | [no description available] | medium | 1 | 0 | | |
| piperidines | [no description available] | medium | 1 | 0 | | |
| atropine | [no description available] | medium | 2 | 0 | | |
| medetomidine | [no description available] | medium | 11 | 1 | imidazoles | |
| vasoactive intestinal peptide | [no description available] | medium | 1 | 0 | | |
| capsaicin | [no description available] | medium | 1 | 0 | capsaicinoid | non-narcotic analgesic;
TRPV1 agonist;
voltage-gated sodium channel blocker |
| idazoxan | [no description available] | medium | 4 | 1 | benzodioxine;
imidazolines | alpha-adrenergic antagonist |
| wb 4101 | [no description available] | medium | 2 | 0 | aromatic ether;
benzodioxine;
secondary amino compound | alpha-adrenergic antagonist |
| aminophylline | [no description available] | medium | 1 | 0 | mixture | bronchodilator agent;
cardiotonic drug |
| caffeine | [no description available] | medium | 1 | 0 | purine alkaloid;
trimethylxanthine | adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic |
| tolmetin | [no description available] | medium | 1 | 0 | aromatic ketone;
monocarboxylic acid;
pyrroles | EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-steroidal anti-inflammatory drug |
| ketorolac | [no description available] | medium | 1 | 0 | amino acid;
aromatic ketone;
monocarboxylic acid;
pyrrolizines;
racemate | analgesic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
non-steroidal anti-inflammatory drug |
| atipamezole | [no description available] | medium | 1 | 0 | | |
| cyclic gmp | [no description available] | medium | 2 | 0 | 3',5'-cyclic purine nucleotide;
guanyl ribonucleotide | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite |
| atrial natriuretic factor | [no description available] | medium | 2 | 0 | polypeptide | |
| dizocilpine maleate | [no description available] | medium | 1 | 0 | maleate salt;
tetracyclic antidepressant | anaesthetic;
anticonvulsant;
neuroprotective agent;
nicotinic antagonist;
NMDA receptor antagonist |
| diazepam | [no description available] | medium | 1 | 0 | 1,4-benzodiazepinone;
organochlorine compound | anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic |
| n-methylaspartate | [no description available] | medium | 1 | 0 | amino dicarboxylic acid;
D-alpha-amino acid;
D-aspartic acid derivative;
secondary amino compound | neurotransmitter agent |
| 6-cyano-7-nitroquinoxaline-2,3-dione | [no description available] | medium | 1 | 0 | quinoxaline derivative | |
| glutamine | [no description available] | medium | 1 | 0 | amino acid zwitterion;
glutamine family amino acid;
glutamine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid | EC 1.14.13.39 (nitric oxide synthase) inhibitor;
Escherichia coli metabolite;
human metabolite;
metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite |
| glutamic acid | [no description available] | medium | 1 | 0 | glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid | Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical |
| heroin | [no description available] | medium | 1 | 0 | morphinane alkaloid | mu-opioid receptor agonist;
opioid analgesic;
prodrug |
| propranolol | [no description available] | medium | 3 | 0 | naphthalenes;
propanolamine;
secondary amine | anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic |
| betaxolol | [no description available] | medium | 1 | 0 | propanolamine | antihypertensive agent;
beta-adrenergic antagonist;
sympatholytic agent |
| ici 118551 | [no description available] | medium | 1 | 0 | aromatic ether;
indanes;
secondary alcohol;
secondary amino compound | beta-adrenergic antagonist |
| melatonin | [no description available] | medium | 1 | 0 | acetamides;
tryptamines | anticonvulsant;
central nervous system depressant;
geroprotector;
hormone;
human metabolite;
immunological adjuvant;
mouse metabolite;
radical scavenger |
| apraclonidine | [no description available] | medium | 1 | 0 | dichlorobenzene;
guanidines;
imidazolines | alpha-adrenergic agonist;
antiglaucoma drug;
beta-adrenergic agonist;
diagnostic agent;
ophthalmology drug |
| l 659066 | [no description available] | medium | 1 | 0 | | |
| oxymetazoline | [no description available] | medium | 1 | 0 | carboxamidine;
imidazolines;
phenols | alpha-adrenergic agonist;
nasal decongestant;
sympathomimetic agent;
vasoconstrictor agent |
| imidazolidines | [no description available] | medium | 1 | 0 | azacycloalkane;
imidazolidines;
saturated organic heteromonocyclic parent | |
| phenoxybenzamine | [no description available] | medium | 1 | 0 | aromatic amine | |
| desipramine | [no description available] | medium | 1 | 0 | dibenzoazepine;
secondary amino compound | adrenergic uptake inhibitor;
alpha-adrenergic antagonist;
antidepressant;
cholinergic antagonist;
drug allergen;
EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
H1-receptor antagonist;
serotonin uptake inhibitor |
| dobutamine | [no description available] | medium | 1 | 0 | catecholamine;
secondary amine | beta-adrenergic agonist;
cardiotonic drug;
sympathomimetic agent |
| carbachol | [no description available] | medium | 1 | 0 | ammonium salt;
carbamate ester | cardiotonic drug;
miotic;
muscarinic agonist;
nicotinic acetylcholine receptor agonist;
non-narcotic analgesic |
| neuropeptide y | [no description available] | medium | 1 | 0 | | |
| eedq | [no description available] | medium | 1 | 0 | | |
| arginine vasopressin | [no description available] | medium | 1 | 0 | vasopressin | cardiovascular drug;
hematologic agent;
mitogen |
| magnesium sulfate | [no description available] | medium | 1 | 0 | magnesium salt;
metal sulfate;
organic magnesium salt | anaesthetic;
analgesic;
anti-arrhythmia drug;
anticonvulsant;
calcium channel blocker;
cardiovascular drug;
fertilizer;
tocolytic agent |
| angiotensin ii | [no description available] | medium | 1 | 0 | amino acid zwitterion;
angiotensin II | human metabolite |
| enkephalin, leucine | [no description available] | medium | 1 | 0 | pentapeptide;
peptide zwitterion | analgesic;
delta-opioid receptor agonist;
human metabolite;
mu-opioid receptor agonist;
neurotransmitter;
rat metabolite |
| enkephalin, leucine-2-alanine | [no description available] | medium | 1 | 0 | | |
| sufentanil | [no description available] | medium | 1 | 0 | anilide;
ether;
piperidines;
thiophenes | anaesthesia adjuvant;
intravenous anaesthetic;
mu-opioid receptor agonist;
opioid analgesic |
| fentanyl | [no description available] | medium | 1 | 0 | anilide;
monocarboxylic acid amide;
piperidines | adjuvant;
anaesthesia adjuvant;
anaesthetic;
intravenous anaesthetic;
mu-opioid receptor agonist;
opioid analgesic |
| enkephalin, ala(2)-mephe(4)-gly(5)- | [no description available] | medium | 1 | 0 | | |
| talipexole | [no description available] | medium | 1 | 0 | azepine | |
| hexamethonium | [no description available] | medium | 1 | 0 | quaternary ammonium salt | |
| 1-(3-chlorophenyl)piperazine | [no description available] | medium | 1 | 0 | monochlorobenzenes;
N-arylpiperazine | drug metabolite;
environmental contaminant;
serotonergic agonist;
xenobiotic |
| 8-bromo cyclic adenosine monophosphate | [no description available] | medium | 1 | 0 | 3',5'-cyclic purine nucleotide;
adenyl ribonucleotide;
organobromine compound | antidepressant;
protein kinase agonist |
| kynurenine | [no description available] | low | 0 | 0 | aromatic ketone;
non-proteinogenic alpha-amino acid;
substituted aniline | human metabolite |
| 3-aminobenzamide | [no description available] | low | 0 | 0 | benzamides;
substituted aniline | EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor |
| alminoprofen | [no description available] | low | 0 | 0 | amino acid;
monocarboxylic acid;
secondary amino compound;
substituted aniline | antipyretic;
antirheumatic drug;
cyclooxygenase 2 inhibitor;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
EC 3.1.1.4 (phospholipase A2) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug |
| amfenac | [no description available] | low | 0 | 0 | amino acid;
benzophenones;
oxo monocarboxylic acid;
primary amino compound;
substituted aniline | antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug |
| aminoglutethimide | [no description available] | low | 0 | 0 | dicarboximide;
piperidones;
substituted aniline | adrenergic agent;
anticonvulsant;
antineoplastic agent;
EC 1.14.14.14 (aromatase) inhibitor |
| benefin | [no description available] | low | 0 | 0 | C-nitro compound;
organofluorine compound;
substituted aniline;
tertiary amino compound | agrochemical;
herbicide |
| benzocaine | [no description available] | low | 0 | 0 | benzoate ester;
substituted aniline | allergen;
antipruritic drug;
sensitiser;
topical anaesthetic |
| bromhexine | [no description available] | low | 0 | 0 | organobromine compound;
substituted aniline;
tertiary amino compound | mucolytic |
| butamben | [no description available] | low | 0 | 0 | amino acid ester;
benzoate ester;
primary amino compound;
substituted aniline | local anaesthetic |
| ci 994 | [no description available] | low | 0 | 0 | acetamides;
benzamides;
substituted aniline | antineoplastic agent;
EC 3.5.1.98 (histone deacetylase) inhibitor |
| clenbuterol | [no description available] | low | 0 | 0 | amino alcohol;
dichlorobenzene;
ethanolamines;
primary arylamine;
secondary amino compound;
substituted aniline | beta-adrenergic agonist;
bronchodilator agent;
sympathomimetic agent |
| dapsone | [no description available] | low | 0 | 0 | substituted aniline;
sulfone | anti-inflammatory drug;
antiinfective agent;
antimalarial;
leprostatic drug |
| metoclopramide | [no description available] | low | 0 | 0 | benzamides;
monochlorobenzenes;
substituted aniline;
tertiary amino compound | antiemetic;
dopaminergic antagonist;
environmental contaminant;
gastrointestinal drug;
xenobiotic |
| entinostat | [no description available] | low | 0 | 0 | benzamides;
carbamate ester;
primary amino compound;
pyridines;
substituted aniline | antineoplastic agent;
apoptosis inducer;
EC 3.5.1.98 (histone deacetylase) inhibitor |
| nemonapride | [no description available] | low | 0 | 0 | benzamides;
monochlorobenzenes;
monomethoxybenzene;
N-alkylpyrrolidine;
secondary amino compound;
secondary carboxamide;
substituted aniline | |
| benoxinate | [no description available] | low | 0 | 0 | amino acid ester;
benzoate ester;
substituted aniline;
tertiary amino compound | drug allergen;
local anaesthetic;
topical anaesthetic |
| pd168393 | [no description available] | low | 0 | 0 | acrylamides;
bromobenzenes;
quinazolines;
secondary carboxamide;
substituted aniline | epidermal growth factor receptor antagonist |
| procaine | [no description available] | low | 0 | 0 | benzoate ester;
substituted aniline;
tertiary amino compound | central nervous system depressant;
drug allergen;
local anaesthetic;
peripheral nervous system drug |
| sulfadiazine | [no description available] | low | 0 | 0 | pyrimidines;
substituted aniline;
sulfonamide antibiotic;
sulfonamide | antiinfective agent;
antimicrobial agent;
antiprotozoal drug;
coccidiostat;
drug allergen;
EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor;
environmental contaminant;
xenobiotic |
| sulfacetamide | [no description available] | low | 0 | 0 | N-sulfonylcarboxamide;
substituted aniline | antibacterial drug;
antiinfective agent;
antimicrobial agent;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor |
| sulfadimethoxine | [no description available] | low | 0 | 0 | aromatic ether;
pyrimidines;
substituted aniline;
sulfonamide antibiotic;
sulfonamide | antiinfective agent;
antimicrobial agent;
drug allergen;
environmental contaminant;
xenobiotic |
| sulfamethoxazole | [no description available] | low | 0 | 0 | isoxazoles;
substituted aniline;
sulfonamide antibiotic;
sulfonamide | antibacterial agent;
antiinfective agent;
antimicrobial agent;
drug allergen;
EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor;
environmental contaminant;
epitope;
P450 inhibitor;
xenobiotic |
| sulfanilamide | [no description available] | low | 0 | 0 | substituted aniline;
sulfonamide antibiotic;
sulfonamide | antibacterial agent;
drug allergen;
EC 4.2.1.1 (carbonic anhydrase) inhibitor |
| sulfaphenazole | [no description available] | low | 0 | 0 | primary amino compound;
pyrazoles;
substituted aniline;
sulfonamide antibiotic;
sulfonamide | antibacterial drug;
EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor;
EC 1.14.13.67 (quinine 3-monooxygenase) inhibitor;
P450 inhibitor |
| sulfapyridine | [no description available] | low | 0 | 0 | pyridines;
substituted aniline;
sulfonamide antibiotic;
sulfonamide | antiinfective agent;
dermatologic drug;
drug allergen;
environmental contaminant;
xenobiotic |
| sulfathiazole | [no description available] | low | 0 | 0 | 1,3-thiazoles;
substituted aniline;
sulfonamide antibiotic;
sulfonamide | antiinfective agent;
drug allergen;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor;
environmental contaminant;
xenobiotic |
| trifluralin | [no description available] | low | 0 | 0 | (trifluoromethyl)benzenes;
C-nitro compound;
substituted aniline | agrochemical;
environmental contaminant;
herbicide;
xenobiotic |
| methyl n-methylanthranilate | [no description available] | low | 0 | 0 | benzoate ester;
methyl ester;
secondary amino compound;
substituted aniline | animal metabolite;
fungal metabolite;
plant metabolite |
| 2,4,6-trimethylaniline | [no description available] | low | 0 | 0 | substituted aniline | |
| anthranilamide | [no description available] | low | 0 | 0 | substituted aniline | |
| 2-anisidine | [no description available] | low | 0 | 0 | monomethoxybenzene;
primary amino compound;
substituted aniline | genotoxin;
reagent |
| 3,3'-diaminobenzidine | [no description available] | low | 0 | 0 | biphenyls;
substituted aniline | histological dye |
| benzidine | [no description available] | low | 0 | 0 | biphenyls;
substituted aniline | carcinogenic agent |
| phenetidine | [no description available] | low | 0 | 0 | aromatic ether;
substituted aniline | |
| 5-nitro-2-methoxyaniline | [no description available] | low | 0 | 0 | 4-nitroanisoles;
substituted aniline | |
| dimethyl-4-phenylenediamine | [no description available] | low | 0 | 0 | diamine;
substituted aniline | |
| 4-(dimethylamino)benzaldehyde | [no description available] | low | 0 | 0 | benzaldehydes;
substituted aniline;
tertiary amino compound | chromogenic compound |
| 3-hydroxydiphenylamine | [no description available] | low | 0 | 0 | substituted aniline | |
| benzonatate | [no description available] | low | 0 | 0 | benzoate ester;
secondary amino compound;
substituted aniline | anaesthetic;
antitussive |
| 4-anisidine | [no description available] | low | 0 | 0 | methoxybenzenes;
primary amino compound;
substituted aniline | genotoxin;
reagent |
| 2-aminothiophenol | [no description available] | low | 0 | 0 | aryl thiol;
substituted aniline | plant metabolite |
| 2,4,5-trimethylaniline | [no description available] | low | 0 | 0 | substituted aniline | |
| 4,4'-thiodianiline | [no description available] | low | 0 | 0 | substituted aniline | |
| anileridine | [no description available] | low | 0 | 0 | ethyl ester;
piperidinecarboxylate ester;
substituted aniline | opioid analgesic;
opioid receptor agonist |
| phenetidine | [no description available] | low | 0 | 0 | aromatic ether;
primary amino compound;
substituted aniline | drug metabolite |
| 4-trifluoromethylaniline | [no description available] | low | 0 | 0 | (trifluoromethyl)benzenes;
substituted aniline | metabolite |
| 3-anisidine | [no description available] | low | 0 | 0 | aromatic ether;
substituted aniline | |
| oxophenarsine | [no description available] | low | 0 | 0 | substituted aniline | |
| c.i. solvent yellow 56 | [no description available] | low | 0 | 0 | azobenzenes;
substituted aniline;
tertiary amino compound | dye;
mutagen |
| asulam | [no description available] | low | 0 | 0 | carbamate ester;
primary amino compound;
substituted aniline;
sulfonamide | agrochemical;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor;
environmental contaminant;
herbicide;
xenobiotic |
| 4-hexyloxyaniline | [no description available] | low | 0 | 0 | aromatic ether;
substituted aniline | |
| pendimethalin | [no description available] | low | 0 | 0 | C-nitro compound;
secondary amino compound;
substituted aniline | agrochemical;
environmental contaminant;
herbicide |
| bromfenac | [no description available] | low | 0 | 0 | aromatic amino acid;
benzophenones;
organobromine compound;
substituted aniline | non-narcotic analgesic;
non-steroidal anti-inflammatory drug |
| sulfametrole | [no description available] | low | 0 | 0 | aromatic ether;
substituted aniline;
sulfonamide antibiotic;
thiadiazoles | |
| sulfaperine | [no description available] | low | 0 | 0 | pyrimidines;
substituted aniline;
sulfonamide antibiotic | antibacterial drug |
| 2-(1H-benzimidazol-2-yl)aniline | [no description available] | low | 0 | 0 | benzimidazoles;
primary arylamine;
substituted aniline | geroprotector |
| aclonifen | [no description available] | low | 0 | 0 | aromatic ether;
C-nitro compound;
monochlorobenzenes;
primary amino compound;
substituted aniline | agrochemical;
carotenoid biosynthesis inhibitor;
EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide |
| mosapride | [no description available] | low | 0 | 0 | aromatic ether;
benzamides;
monochlorobenzenes;
monofluorobenzenes;
morpholines;
secondary carboxamide;
substituted aniline;
tertiary amino compound | |
| ezogabine | [no description available] | low | 0 | 0 | carbamate ester;
organofluorine compound;
secondary amino compound;
substituted aniline | anticonvulsant;
potassium channel modulator |
| 1-(2-(4-aminophenyl)ethyl)-4-(3-trifluoromethylphenyl)piperazine | [no description available] | low | 0 | 0 | (trifluoromethyl)benzenes;
N-alkylpiperazine;
N-arylpiperazine;
primary arylamine;
substituted aniline | geroprotector;
serotonergic agonist |
| 4-aminophenyl alpha-d-mannopyranoside | [no description available] | low | 0 | 0 | alpha-D-mannoside;
substituted aniline | |
| aminopotentidine | [no description available] | low | 0 | 0 | aromatic ether;
benzamides;
guanidines;
nitrile;
piperidines;
substituted aniline | H2-receptor antagonist |
| 4-aminobenzoylglutamic acid | [no description available] | low | 0 | 0 | dicarboxylic acid;
dipeptide;
N-acyl-L-alpha-amino acid;
substituted aniline | |
| 2-[2-[2-(2-aminophenoxy)ethoxy]ethoxy]aniline | [no description available] | low | 0 | 0 | aromatic ether;
substituted aniline | |
| 6-(2-chloroanilino)-4-oxo-2-(4-pyridyl)-3,4-dihydro-2H-1,3-thiazine-5-carbonitrile | [no description available] | low | 0 | 0 | substituted aniline | |
| N2-phenyl-5-methyl-4,5-dihydro-1,3-thiazol-2-amine | [no description available] | low | 0 | 0 | substituted aniline | |
| gant 61 | [no description available] | low | 0 | 0 | aminal;
dialkylarylamine;
pyridines;
substituted aniline;
tertiary amino compound | antineoplastic agent;
apoptosis inducer;
glioma-associated oncogene inhibitor;
Hedgehog signaling pathway inhibitor |
| 3-(2,4-difluoroanilino)-5,5-dimethyl-1-cyclohex-2-enone | [no description available] | low | 0 | 0 | substituted aniline | |
| cgp 60474 | [no description available] | low | 0 | 0 | substituted aniline | |
| 4,4-dimethyl-N2-(2-methylphenyl)-1H-1,3,5-triazine-2,6-diamine | [no description available] | low | 0 | 0 | substituted aniline | |
| brd32048 | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| stf 62247 | [no description available] | low | 0 | 0 | substituted aniline | |
| N-(3-fluorophenyl)-2-(pyridin-4-yl)quinazolin-4-amine | [no description available] | low | 0 | 0 | aromatic amine;
monofluorobenzenes;
pyridines;
quinazolines;
secondary amino compound;
substituted aniline | |
| 4-chloro-N-(3,4,5-trimethoxyphenyl)-5-dithiazolimine | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| 5-amino-3-(4-methoxyphenyl)-4-oxo-1-thieno[3,4-d]pyridazinecarboxylic acid ethyl ester | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| 6-anilino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione | [no description available] | low | 0 | 0 | substituted aniline | |
| 3-(2-Methyl-1,3-thiazol-4-yl)aniline | [no description available] | low | 0 | 0 | substituted aniline | |
| N-phenyl-4-pyridin-4-yl-2-thiazolamine | [no description available] | low | 0 | 0 | substituted aniline | |
| 4-(4-(4-chloro-phenyl)thiazol-2-ylamino)phenol | [no description available] | low | 0 | 0 | substituted aniline | |
| 1-[[(1,5-dimethyl-3-pyrazolyl)-oxomethyl]amino]-3-(2-methoxyphenyl)thiourea | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| 1-(4-methoxyphenyl)-3-[[oxo(thiophen-2-yl)methyl]amino]thiourea | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| N2,N4-bis(4-methoxyphenyl)pyrimidine-2,4-diamine | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| N4-(4-methoxyphenyl)-1,3,5-triazaspiro[5.5]undeca-1,4-diene-2,4-diamine | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| 4-mercapto-5-(4-methoxyphenyl)-2-oxo-1,5-diazaspiro[5.5]undec-3-ene-3-carbonitrile | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| 4-[2-(3-methoxyanilino)-4-thiazolyl]phenol | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| 2-(4-methylanilino)-4-pyrido[3,2-e][1,3]thiazinone | [no description available] | low | 0 | 0 | substituted aniline | |
| N-(3-chloro-4-methoxyphenyl)-4,6-dimethoxy-1,3,5-triazin-2-amine | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| 6-[[(4,6-dimethyl-2-pyrimidinyl)thio]methyl]-N2-(4-methoxyphenyl)-1,3,5-triazine-2,4-diamine | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| N-(4-fluorophenyl)-4-(3-pyridinyl)-2-thiazolamine | [no description available] | low | 0 | 0 | substituted aniline | |
| 3-(4-methoxyphenyl)-2-(4-methoxyphenyl)imino-4-thiazolidinone | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| 3-(4-methoxyphenyl)-2,4-dihydrothiazolo[3,2-a][1,3,5]triazin-6-one | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| 7-anilino-3-(4-bromophenyl)-5-(4-morpholinyl)-1,4-thiazepine-6-carbonitrile | [no description available] | low | 0 | 0 | substituted aniline | |
| 4,6-bis(1-imidazolyl)-N,N-diphenyl-1,3,5-triazin-2-amine | [no description available] | low | 0 | 0 | substituted aniline | |
| 1-(3-methoxyphenyl)-3-[[3-(4-nitro-1-pyrazolyl)-1-oxopropyl]amino]thiourea | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| N-(5-chloro-2-methoxyphenyl)-5-pyridin-4-yl-1,3,4-thiadiazol-2-amine | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| 1-[[(4-bromo-2-methyl-3-pyrazolyl)-oxomethyl]amino]-3-(2-methoxy-5-methylphenyl)thiourea | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| N-(4-chlorophenyl)-4-methyl-2-thiazolamine | [no description available] | low | 0 | 0 | substituted aniline | |
| N4-(2-methoxyphenyl)benzene-1,4-diamine | [no description available] | low | 0 | 0 | aromatic ether;
substituted aniline | |
| N-{3-[(2-phenylquinazolin-4-yl)amino]phenyl}acetamide | [no description available] | low | 0 | 0 | acetamide;
aromatic amine;
quinazolines;
secondary amino compound;
substituted aniline | |
| 1-[2-[[5-(2-methoxyanilino)-1,3,4-thiadiazol-2-yl]thio]-1-oxoethyl]-2-pyrrolidinone | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| 5-anilino-3-oxo-4-isothiazolecarbonitrile | [no description available] | low | 0 | 0 | substituted aniline | |
| 5-(4-chloroanilino)-3-oxo-4-isothiazolecarbonitrile | [no description available] | low | 0 | 0 | substituted aniline | |
| 5-(2-chloroanilino)-3-oxo-4-isothiazolecarbonitrile | [no description available] | low | 0 | 0 | substituted aniline | |
| N-(2-chlorophenyl)-4-(1-pyrrolyl)-1,3,5-triazin-2-amine | [no description available] | low | 0 | 0 | substituted aniline | |
| 1-(3-methoxyphenyl)-3-(methyl-oxo-phenyl-$l^{6}-sulfanylidene)thiourea | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| 5-(4-methoxyanilino)-2-[(3-methylphenoxy)methyl]-4-oxazolecarbonitrile | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| sulfathiourea | [no description available] | low | 0 | 0 | substituted aniline;
sulfonamide antibiotic;
thioureas | antibacterial drug;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor |
| u 0126 | [no description available] | low | 0 | 0 | aryl sulfide;
dinitrile;
enamine;
substituted aniline | antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
osteogenesis regulator;
vasoconstrictor agent |
| 2-(4-ethoxy-3-methoxyphenyl)-4-mercapto-3-(4-methoxyphenyl)-6-oxo-1,2-dihydropyrimidine-5-carbonitrile | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| N4-(2-furanylmethyl)-N2-(3-methoxyphenyl)-5-nitropyrimidine-2,4,6-triamine | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| ferrostatin-1 | [no description available] | low | 0 | 0 | ethyl ester;
primary arylamine;
substituted aniline | antifungal agent;
antioxidant;
ferroptosis inhibitor;
neuroprotective agent;
radiation protective agent;
radical scavenger |
| 1-[[2-(2,4-dichlorophenoxy)-1-oxoethyl]amino]-3-(4-methoxyphenyl)thiourea | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| sb 415286 | [no description available] | low | 0 | 0 | C-nitro compound;
maleimides;
monochlorobenzenes;
phenols;
secondary amino compound;
substituted aniline | antioxidant;
apoptosis inducer;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
neuroprotective agent |
| 2-[[6-amino-2-(4-methoxyanilino)-5-nitro-4-pyrimidinyl]amino]ethanol | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| N-(3-{[2-(2-fluorophenyl)quinazolin-4-yl]amino}phenyl)acetamide | [no description available] | low | 0 | 0 | acetamide;
aromatic amine;
monofluorobenzenes;
quinazolines;
secondary amino compound;
substituted aniline | |
| 1-amino-3-(4-chloro-2-methoxy-5-methylphenyl)thiourea | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| 5-(3-chloroanilino)-3H-1,3,4-thiadiazole-2-thione | [no description available] | low | 0 | 0 | substituted aniline | |
| 2-(2-methoxyanilino)-2-(2-phenylmethoxyphenyl)acetonitrile | [no description available] | low | 0 | 0 | aromatic ether;
substituted aniline | |
| 1-[2,5-dimethyl-1-(2-oxolanylmethyl)-3-pyrrolyl]-2-[[5-(4-methoxyanilino)-1,3,4-thiadiazol-2-yl]thio]ethanone | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| bibx 1382bs | [no description available] | low | 0 | 0 | substituted aniline | |
| mocetinostat | [no description available] | low | 0 | 0 | aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline | antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent |
| solabegron | [no description available] | low | 0 | 0 | carboxybiphenyl;
monochlorobenzenes;
secondary alcohol;
secondary amino compound;
substituted aniline | beta-adrenergic agonist |
| 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| cardiogenol c | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| bay94 9172 | [no description available] | low | 0 | 0 | (18)F radiopharmaceutical;
aromatic ether;
polyether;
secondary amino compound;
stilbenoid;
substituted aniline | radioactive imaging agent |
| N-[5-[2-(2-methoxyanilino)-4-thiazolyl]-4-methyl-2-thiazolyl]-2-methylpentanamide | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| N-[5-[2-(5-chloro-2-methoxyanilino)-4-thiazolyl]-4-methyl-2-thiazolyl]hexanamide | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| N-[5-[2-(3-methoxyanilino)-4-thiazolyl]-4-methyl-2-thiazolyl]-3-methylbutanamide | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| N-[5-[2-(2-methoxyanilino)-4-thiazolyl]-4-methyl-2-thiazolyl]heptanamide | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| N-[5-[2-(2-methoxyanilino)-4-thiazolyl]-4-methyl-2-thiazolyl]pentanamide | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| N-[5-[2-(3-methoxyanilino)-4-thiazolyl]-4-methyl-2-thiazolyl]heptanamide | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| zm323881 | [no description available] | low | 0 | 0 | aromatic ether;
benzyl ether;
fluorophenol;
halophenol;
monofluorobenzenes;
organic cation;
quinazolines;
secondary amino compound;
substituted aniline | vascular endothelial growth factor receptor antagonist |
| jsh 23 | [no description available] | low | 0 | 0 | diamine;
substituted aniline | NF-kappaB inhibitor |
| 2-[[4-(5-chloro-2-methoxyanilino)-6-(1-piperidinyl)-1,3,5-triazin-2-yl]amino]ethanol | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| 2-[[4-(2-methoxyanilino)-6-(1-pyrrolidinyl)-1,3,5-triazin-2-yl]amino]ethanol | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| 2-[[4-(3-methoxyanilino)-6-(1-pyrrolidinyl)-1,3,5-triazin-2-yl]amino]ethanol | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| 2-[[4-(4-methoxyanilino)-6-(1-pyrrolidinyl)-1,3,5-triazin-2-yl]amino]ethanol | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| 4-[[4-(2-methoxyanilino)-6-(1-pyrrolidinyl)-1,3,5-triazin-2-yl]amino]-1-butanol | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| florbetapir f 18 | [no description available] | low | 0 | 0 | (18)F radiopharmaceutical;
aromatic ether;
organofluorine compound;
pyridines;
substituted aniline | radioactive imaging agent |
| (5S)-1-heptyl-5-(2-methylpropyl)-N-phenyl-4,5-dihydroimidazol-2-amine | [no description available] | low | 0 | 0 | substituted aniline | |
| SL-327 | [no description available] | low | 0 | 0 | (trifluoromethyl)benzenes;
enamine;
nitrile;
organic sulfide;
primary amino compound;
substituted aniline | EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor;
neuroprotective agent |
| GRL-0617 | [no description available] | low | 0 | 0 | benzamides;
naphthalenes;
secondary carboxamide;
substituted aniline | anticoronaviral agent;
protease inhibitor |
| poziotinib | [no description available] | low | 0 | 0 | acrylamides;
aromatic ether;
dichlorobenzene;
diether;
monofluorobenzenes;
N-acylpiperidine;
quinazolines;
secondary amino compound;
substituted aniline | antineoplastic agent;
apoptosis inducer;
epidermal growth factor receptor antagonist |
| GDC-0623 | [no description available] | low | 0 | 0 | hydroxamic acid ester;
imidazopyridine;
monofluorobenzenes;
organoiodine compound;
primary alcohol;
secondary amino compound;
substituted aniline | antineoplastic agent;
apoptosis inducer;
EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor |
| ML355 | [no description available] | low | 0 | 0 | benzothiazoles;
monomethoxybenzene;
phenols;
secondary amino compound;
substituted aniline;
sulfonamide | EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor;
platelet aggregation inhibitor |
| osimertinib | [no description available] | low | 0 | 0 | acrylamides;
aminopyrimidine;
biaryl;
indoles;
monomethoxybenzene;
secondary amino compound;
secondary carboxamide;
substituted aniline;
tertiary amino compound | antineoplastic agent;
epidermal growth factor receptor antagonist |
| ((5z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4h-imidazol-4-one) | [no description available] | low | 0 | 0 | benzodioxoles;
imidazolone;
substituted aniline | autophagy inducer;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor;
EC 2.7.12.1 (dual-specificity kinase) inhibitor;
neuroprotective agent;
nootropic agent |
| 1-(3-methoxyphenyl)-2-[4-oxo-6-(trifluoromethyl)-1H-pyrimidin-2-yl]guanidine | [no description available] | low | 0 | 0 | methoxybenzenes;
substituted aniline | |
| 2-(4-fluoroanilino)-6-methyl-5-(3-methylbutyl)-1H-pyrimidin-4-one | [no description available] | low | 0 | 0 | substituted aniline | |