Page last updated: 2024-08-23

enkephalin, methionine and Pain

enkephalin, methionine has been researched along with Pain in 146 studies

Research

Studies (146)

TimeframeStudies, this research(%)All Research%
pre-199075 (51.37)18.7374
1990's25 (17.12)18.2507
2000's31 (21.23)29.6817
2010's12 (8.22)24.3611
2020's3 (2.05)2.80

Authors

AuthorsStudies
Chen, D; Fang, Q; Hu, X; Li, N; Shi, Y; Xu, B; Zhang, M; Zhang, N; Zhang, Q; Zhang, R1
Cheng, W; Hu, J; Huang, S; Sun, S; Tian, F1
Baamonde, A; Cernuda-Cernuda, R; Fernández-García, MT; Folgueras, AR; García-Domínguez, M; Hidalgo, A; Lastra, A; Menéndez, L1
Aloisi, AM; Ashrafi, M; Pirzadeh, S; Sajedianfard, J1
Chavarría-Bolaños, D; Flores-Reyes, H; Lombana, N; Martinez-Zumaran, A; Pozos-Guillen, A1
Eichenbaum, H; Karom, MC; Murphy, AZ; Victoria, NC1
Li, D; Li, H1
Chung, E; Ohgami, Y; Quock, RM; Shirachi, DY; Zelinski, LM1
Westlund, KN1
Brack, A; Hackel, D; Labuz, D; Mousa, S; Rittner, HL; Schaefer, M; Schäfer, M; Stein, C; Stolz, A; Voigt, P1
Hino, M; Horiuchi, H; Morino, T; Ogata, T; Yamamoto, H1
Chu, J; Lin, BC; Liu, WY; Wang, G; Xu, H; Yang, J; Yang, Y; Yuan, H1
Bourgoin, S; Cesselin, F; Hamon, M; Le Bars, D; Mauborgne, A1
Fu, Y; Hong, YG; Jiang, JP1
Hao, F; Li, P; Liang, JY; Pan, YJ; Qiu, PY; Wang, DX; Yang, J; Zhang, J1
Shimoyama, M; Shimoyama, N; Tagaito, Y; Toyama, S1
Maturana, P; Mosnaim, AD; Puente, J; Wolf, ME1
Bryant, L; Chen, Z; Doyle, T; Ghaffari, M; Little, JW; Neumann, WL; Porreca, F; Salvemini, D1
Fournie-Zaluski, MC; Gore, C; Labuz, D; Machelska, H; Roques, BP; Schreiter, A; Stein, C1
Blisnick, T; Desor, D; Dugave, C; Hermitte, V; Messaoudi, M; Rigault, AG; Rougeon, F; Rougeot, C1
Labuz, D; Machelska, H; Mousa, SA; Schäfer, M; Schopohl, JK; Stein, C1
Dai, P; Hong, Y; Jiang, J; Zeng, X1
Cox, ML; Welch, SP1
Duplan, H; Eaton, MJ; Emorine, L; Herman, JP; Lazorthes, Y; Li, RY; Tafani, M; Vue, C; Zhou, H1
Hong, Y; Huang, H; Zeng, X1
Baraniuk, JN; Clauw, DJ; Cunningham, J; Whalen, G1
Goldstein, JM; Malick, JB1
Lisi, TL; Sluka, KA1
Ahsan, A; Hanif, K; Maiti, S; Masand, G; Pasha, S; Sen, S1
Pappas, GD; Qu, T; Sugaya, I; Sugaya, K1
Gupta, K; Gupta, S; Gupta, YK; Hanif, K; Maiti, S; Pasha, S1
Chen, JM; Lin, BC; Liu, WY; Xu, HT; Yang, J; Yang, Y1
Cai, M; Chen, T; Hong, Y; Quirion, R1
Jin, XL; Kobayashi, H; Kosaka, K; Oka, T; Takahashi, S; Yoshikawa, M1
Kiguchi, N; Kishioka, S; Maeda, T; Ozaki, M; Tsuruga, M; Yamamoto, A; Yamamoto, C1
Takagi, H1
Tsai, HY1
Herz, A1
Duggan, AW; Foong, FW; Zhao, ZQ1
Agnoli, A; Ceci, E; Denaro, A; Falaschi, P1
Bhargava, KP; Nath, C; Pant, KK; Sinha, JN1
Herz, A; Millan, MH; Millan, MJ; Przewłocki, R1
Altshuler, KZ; Bhatia, K; Gatchel, RJ; Huang, XY; Khatami, MJ; Kiser, RS1
Quirion, R1
Haigler, HJ; Spring, DD1
Del Rio, J; Naranjo, JR1
Haigler, HJ; Hosford, DA2
Ehrenpreis, S1
Chaillet, P; Costentin, J; Coulaud, A; Fournié-Zaluski, MC; Gacel, G; Roques, BP1
Covelli, V; Faccini, E; Govoni, S; Missale, C; Spano, PF; Trabucchi, M; Uzumaki, H1
Arluison, M; Bourgoin, S; Cesselin, F; Conrath-Verrier, M; Dietl, M; Hamon, M1
Fei, H; Han, JS; Zhou, ZF1
Artaud, F; Bourgoin, S; Cesselin, F; Hamon, M; Montastruc, JL; Rascol, A; Testut, MF1
Peets, JM; Pomeranz, B; Power, C1
Costa, E; Tang, J; Yang, HY1
Sourek, K; Zichová, M1
Livingston, A; Morris, B1
Berntson, GG; Couri, D; McGivern, RF; Mousa, S1
Ignatov, IuD; Kovalenko, VS; Titov, MI; Vasil'ev, IuN1
Barbeau, A; Izumi, K; Munekata, E; Nakanishi, T; Yamamoto, H1
Frederickson, RC; Wesche, DL1
Boudouresque, F; Giraud, P; Guieu, R; Tardy-Gervet, MF1
Mi, ZP; Qiao, JT; Zhang, RX1
Ayala, J; Del Valle, M; Fuente, T; Hernández, LC; Iglesias, L; López, JM; Seijo, F1
Carter, L; Schäfer, M; Stein, C1
Portoghese, PS; Takemori, AE1
Bach, FW; Yaksh, TL1
Beitz, AJ; Mullet, MA; Williams, FG1
Goldstein, BD; Zachariou, V1
Ekblom, A; Ekman-Ordeberg, G; Irestedt, L; Nyberg, F; Olofsson, C; Ungerstedt, U; Wiklund, P1
Kampine, JP; Mizoguchi, H; Narita, M; Tseng, LF1
Deguchi, T; Imano, K; Kita, A; Nakamura, H; Seto, Y; Yakuo, I1
Aebischer, P; Buchser, E; Décosterd, I; Gilliard, N; Saydoff, J; Zurn, AD1
Ballof, J; Exton, MS; Exton, NG; Helfritz, F; Meyer, D; Nave, H; Pabst, R; Radulovic, J; Schmidt, RE; Stalp, M; Straub, RH; von Hörsten, S1
Fan, XT; Kitamura, K; Oka, T; Taniguchi, T1
Bytner, B; Lundeberg, T; Nylander, I; Rosén, A1
Bès, JC; Duplan, H; Lazorthes, Y; Sagen, J; Sallerin, B; Sol, JC; Tafani, M; Tkaczuk, J1
Eaton, MJ; Frydel, BR; Huang, J; Lopez, TL; McKillop, J; Nie, XT; Sagen, J1
Huh, SO; Kim, YH; Song, DK; Suh, HW1
Bette, M; Haake, M; Thon, A1
Hung, K; Mizoguchi, H; Ohsawa, M; Tseng, LF; Wu, H1
Bhardwaj, DK; Gupta, S; Gupta, YK; Pasha, S1
Cabot, PJ; Carter, L; Schäfer, M; Stein, C1
Fujimura, T; Hayashi, T; Kastin, AJ; Murayama, K; Narita, M; Orito, T; Sakurada, C; Sakurada, S; Sakurada, T; Suzuki, T; Tan-no, K; Tseng, LF; Yuhki, M; Zadina, JE1
Ahmed, M; Bileviciute-Ljungar, I; Kreicbergs, A; Lundeberg, T; Nylander, I; Rydelius, G; Spetea, M; Svensson, S1
Collins, KA; Suh, HH; Tseng, LF1
Gavrilova, EM; Khegai, LA; Kim, BB; Yanovsky, OG; Zaitsev, SV; Zakharova, LA1
Arai, Y; Ghoda, K; Kajita, T; Liu, XF; Matsumiya, T; Ohgiya, N; Oka, T; Taniguchi, T1
Herz, A; Nikolarakis, K; Shippenberg, TS1
Nakai, Y; Shioda, S; Wang, QP1
Gramsch, C; Hassan, AH; Herz, A; Peter, K; Przewłocki, R; Stein, C1
Rosenfeld, JP; Xia, LY1
Bruchelt, G; Gupta, D; Handgretinger, R; Kaleva, N; Klingebiel, T; Niethammer, D; Treuner, J; Wollmann, H1
Barontini, MB; Figuerola, ML; Leston, JA; Vindrola, O1
Bourgoin, S; Cesselin, F; Clot, AM; Hamon, M; Le Bars, D3
Himmelfarb, GN; Schumilowa, IJ1
Inoki, R; Shibutani, T; Tsai, HY; Yonehara, N1
Folkesson, R; Kisara, K; Sakurada, S; Sakurada, T; Takahashi, K; Terenius, L1
Bourgoin, S; Cesselin, F; Fattaccini, CM; Gozlan, H; Hamon, M; Montastruc, JL; Rascol, A; Tran, MA1
De Felipe, MC; Del Río, J; Molinero, MT1
Inoki, R; Lin, JG; Tsai, HY1
Wang, SK; Wang, YJ1
Colpaert, FC; Członkowski, A; Herz, A; Millan, MH; Millan, MJ; Pilcher, CW1
Candeletti, S; Ferri, S; Mantegazza, P; Panerai, AE; Sacerdote, P; Spampinato, S1
Colpaert, FC; Członkowski, A; Herz, A; Höllt, V; Millan, MH; Millan, MJ; Pilcher, CW1
Inoki, R; Kudo, T; Ohkubo, T; Shibata, M; Takahashi, H1
Pezalla, PD; Stevens, CW; Yaksh, TL1
Dyer, RS; Grimes, L; Harry, GJ; Hong, JS; Peterson, NJ; Rogers, BC; Tilson, HA1
Pappas, GD; Sagen, J1
Brown, MJ; Chierchia, S; Glazier, JJ; Maseri, A1
Bianchi, M; Brini, A; Cocco, E; Marini, A; Panerai, AE; Sacerdote, P1
Grossman, A1
Artaud, F; Besson, JM; Bourgoin, S; Cesselin, F; Clot, AM; Gozlan, H; Hamon, M; Le Bars, D1
Kameyama, T; Matsuno, K; Nabeshima, T1
Biondi, M; Carilli, L; Fabbri, A; Fraioli, F; Moretti, C; Pancheri, P; Perrone, G; Santoro, A; Zichella, L1
Kamei, H; Kameyama, T; Matsuno, K; Nabeshima, T; Noda, Y1
Chang, JK; Huang, XH; Lu, WX; Mo, WY; Xu, SF; Xu, WM; Zhang, AZ; Zhou, KR1
Sanchez, R; Vargas, L1
Karczag, I; Székely, JI; Till, M; Tolna, J; Török, K1
Inoki, R; Kudo, T; Nakao, T; Terasawa, M; Wei, EQ1
Barchas, JD; Belluzzi, JD; Evans, CJ; Leslie, FM; Stein, L; Stevens, KE1
Bourgoin, S; Cesselin, F; Dickenson, AH; Fournié-Zaluski, MC; Hamon, M; Le Bars, D; Roques, BP1
Wang, XT; Wu, JL1
Brandman, S; Currie, WJ; Jenkins, R; Vandenburg, MJ1
Dodds, WN; Jayson, MI; Jones, CA; Rees, JM1
Kubota, K; Matsuoka, Y; Satoh, S; Uruno, T1
Faermark, IF; Shvarts, GIa1
Bourgoin, S; Cesselin, F; Clot, MA; Hamon, M; Le Bars, D1
Kurumaji, A; Ohi, K; Takahashi, K; Takashima, M1
García-Antón, JM; Reig, F; Rodríguez, RE; Torres, JL; Valencia, G1
Baker, M; de Ceballos, ML; Jenner, P; Marsden, CD; Rose, S1
Rosenfeld, JP1
Aimone, LD; Gebhart, GF; Randich, A1
Bourgoin, S; Cesselin, F; Clot, AM; Hamon, M; Le Bars, D; Villanueva, L1
Amann, R; Barthó, L; Lembeck, F; Saria, A; Szolcsányi, J1
Han, JS; Shi, YS; Yu, LC1
Fukushima, N; Ge, M; Kitao, T; Takagi, H; Ueda, H1
Kasman, GS; Rosenfeld, JP1
Hirota, N; Kuraishi, Y; Satoh, M; Takagi, H1
Guan, XM; Li, LG; Liang, XC; Liu, XC; Wang, CY; Zeng, XY; Zhang, YW1
Haigler, HJ; Hardy, SG1
Apostol, CR; Davis, P; Forte, BL; Giri, AK; Hruby, VJ; Largent-Milnes, TM; Molnar, G; Olson, KM; Porreca, F; Rankin, D; Vanderah, TW; Wang, Y1
Domon, Y; Fujimoto, T; Kawase, Y; Kubota, K; Noguchi, T; Shimada, K; Takano, R; Ueda, K; Umezaki, Y; Yabe, K; Yokoyama, M1

Reviews

4 review(s) available for enkephalin, methionine and Pain

ArticleYear
Gene therapy for pancreatitis pain.
    Gene therapy, 2009, Volume: 16, Issue:4

    Topics: Animals; Disease Models, Animal; Enkephalin, Methionine; Genetic Therapy; Genetic Vectors; Humans; Pain; Pain Management; Pancreatic Neoplasms; Pancreatitis, Chronic; Rats

2009
Pain, nociception and spinal opioid receptors.
    Progress in neuro-psychopharmacology & biological psychiatry, 1984, Volume: 8, Issue:4-6

    Topics: Animals; Dogs; Dynorphins; Endorphins; Enkephalin, Methionine; Guinea Pigs; Injections, Spinal; Mice; Pain; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Thermosensing; Touch

1984
Possible involvement of taurine and GABA in morphine-like peptide actions.
    International journal of neurology, 1980, Volume: 14, Issue:2-4

    Topics: Amino Acids; Analgesia; Animals; Enkephalin, Methionine; gamma-Aminobutyric Acid; Humans; Male; Motor Activity; Movement Disorders; Pain; Rats; Taurine

1980
Functional response of multiple opioid systems to chronic arthritic pain in the rat.
    Annals of the New York Academy of Sciences, 1986, Volume: 467

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Arthritis; Arthritis, Experimental; Benzomorphans; beta-Endorphin; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Morphine; Naloxone; Nociceptors; Pain; Pituitary Gland, Anterior; Protein Precursors; Pyrrolidines; Rats; Receptors, Opioid; Sensory Thresholds; Spinal Cord; Thalamus

1986

Trials

3 trial(s) available for enkephalin, methionine and Pain

ArticleYear
Expression of substance P, calcitonin gene-related peptide, β-endorphin and methionine-enkephalin in human dental pulp tissue after orthodontic intrusion: a pilot study.
    The Angle orthodontist, 2014, Volume: 84, Issue:3

    Topics: Adolescent; beta-Endorphin; Bicuspid; Calcitonin Gene-Related Peptide; Child; Dental Pulp; Enkephalin, Methionine; Female; Humans; Male; Neurogenic Inflammation; Neurotransmitter Agents; Opioid Peptides; Pain; Pilot Projects; Substance P; Tooth Movement Techniques

2014
Cerebrospinal fluid levels of opioid peptides in fibromyalgia and chronic low back pain.
    BMC musculoskeletal disorders, 2004, Dec-09, Volume: 5

    Topics: Adult; Aged; Chronic Disease; Enkephalin, Methionine; Fatigue Syndrome, Chronic; Female; Fibromyalgia; Humans; Low Back Pain; Male; Middle Aged; Nociceptin; Opioid Peptides; Pain; Pain Measurement

2004
Human chromaffin cell graft into the CSF for cancer pain management: a prospective phase II clinical study.
    Pain, 2000, Volume: 87, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chromaffin Cells; Enkephalin, Methionine; Feasibility Studies; Female; Humans; Injections, Spinal; Male; Middle Aged; Morphine; Neoplasms; Pain; Pain Measurement; Pilot Projects; Prospective Studies; Severity of Illness Index; Transplantation, Homologous; Treatment Outcome

2000

Other Studies

139 other study(ies) available for enkephalin, methionine and Pain

ArticleYear
Na
    The journal of pain, 2023, Volume: 24, Issue:5

    Topics: Analgesics; Animals; Enkephalin, Methionine; Enkephalins; Ganglia, Spinal; Hyperalgesia; Mice; NAV1.7 Voltage-Gated Sodium Channel; Pain; Rats

2023
Effects of botulinum toxin A on endometriosis‑associated pain and its related mechanism.
    Molecular medicine reports, 2020, Volume: 22, Issue:5

    Topics: Adult; Animals; Botulinum Toxins, Type A; Cell Survival; Disease Models, Animal; Endometriosis; Enkephalin, Methionine; Female; Glucose; Humans; Mice; Mice, Inbred BALB C; Norepinephrine; Pain; PC12 Cells; Rats

2020
The Chemokine CCL4 (MIP-1β) Evokes Antinociceptive Effects in Mice: a Role for CD4
    Molecular neurobiology, 2019, Volume: 56, Issue:3

    Topics: Analgesics; Animals; CD4-Positive T-Lymphocytes; Chemokine CCL4; Enkephalin, Methionine; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Pain; Pain Measurement

2019
Effects of Intracerebroventricular and Intra-Arcuate Nucleus Injection of Ghrelin on Pain Behavioral Responses and Met-Enkephalin and β-Endorphin Concentrations in the Periaqueductal Gray Area in Rats.
    International journal of molecular sciences, 2019, May-19, Volume: 20, Issue:10

    Topics: Animals; Arcuate Nucleus of Hypothalamus; beta-Endorphin; Enkephalin, Methionine; Ghrelin; Injections; Male; Pain; Pain Measurement; Periaqueductal Gray; Rats

2019
Neonatal injury rapidly alters markers of pain and stress in rat pups.
    Developmental neurobiology, 2014, Volume: 74, Issue:1

    Topics: Animals; Animals, Newborn; beta-Endorphin; Biomarkers; Brain Chemistry; Carrageenan; Corticosterone; Enkephalin, Methionine; Female; Inflammation; Pain; Pregnancy; Rats; Rats, Sprague-Dawley; Spinal Cord; Stress, Psychological

2014
Preparation of a pipette tip-based molecularly imprinted solid-phase microextraction monolith by epitope approach and its application for determination of enkephalins in human cerebrospinal fluid.
    Journal of pharmaceutical and biomedical analysis, 2015, Nov-10, Volume: 115

    Topics: Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Epitopes; Equipment Design; Humans; Limit of Detection; Microscopy, Electron, Scanning; Molecular Imprinting; Neoplasms; Pain; Polymers; Reproducibility of Results; Solid Phase Microextraction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Surface Properties

2015
A prolonged nitric oxide-dependent, opioid-mediated antinociceptive effect of hyperbaric oxygen in mice.
    The journal of pain, 2009, Volume: 10, Issue:2

    Topics: Acetic Acid; Analgesia; Analysis of Variance; Animals; beta-Endorphin; Citrulline; Dynorphins; Enkephalin, Methionine; Enzyme Inhibitors; Hyperbaric Oxygenation; Injections, Intraperitoneal; Male; Mice; Microinjections; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Measurement; Thiourea

2009
Mycobacteria attenuate nociceptive responses by formyl peptide receptor triggered opioid peptide release from neutrophils.
    PLoS pathogens, 2009, Volume: 5, Issue:4

    Topics: Analysis of Variance; Animals; Calcium; Cyclosporine; Enkephalin, Methionine; Freund's Adjuvant; Humans; Male; Monocytes; Mycobacterium; Narcotic Antagonists; Neurotransmitter Agents; Neutrophils; Nociceptors; Opioid Peptides; Pain; Phosphatidylinositol 3-Kinases; Rats; Rats, Wistar; Receptors, Formyl Peptide; Toll-Like Receptors

2009
Intrathecal transplantation of autologous macrophages genetically modified to secrete proenkephalin ameliorated hyperalgesia and allodynia following peripheral nerve injury in rats.
    Neuroscience research, 2009, Volume: 64, Issue:1

    Topics: Animals; Cells, Cultured; Enkephalin, Methionine; Enkephalins; Hot Temperature; Humans; Hyperalgesia; Injections, Spinal; Macrophages; Male; Pain; Pain Management; Pain Measurement; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Sciatic Neuropathy; Spinal Cord; Time Factors; Transfection; Transplantation, Autologous

2009
Arginine vasopressin antinociception in the rat nucleus raphe magnus is involved in the endogenous opiate peptide and serotonin system.
    Peptides, 2009, Volume: 30, Issue:7

    Topics: Analgesics; Animals; Arginine Vasopressin; Choline; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Glutamic Acid; Indoles; Male; Opioid Peptides; Oxytocin; Pain; Pain Measurement; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin

2009
Freezing of enkephalinergic functions by multiple noxious foci: a source of pain sensitization?
    PloS one, 2009, Sep-03, Volume: 4, Issue:9

    Topics: Animals; Enkephalin, Methionine; Enkephalins; Extremities; Male; Neural Inhibition; Pain; Protein Precursors; Rabbits; Rats; Rats, Sprague-Dawley; Spinal Cord; Trigeminal Caudal Nucleus; Trigeminal Nucleus, Spinal

2009
[Bovine adrenal medulla 22 attenuates hyperalgesia in the early phase of complete Freund's adjuvant-induced inflammation in rats].
    Sheng li xue bao : [Acta physiologica Sinica], 2011, Feb-25, Volume: 63, Issue:1

    Topics: Animals; Calcitonin Gene-Related Peptide; Enkephalin, Methionine; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled

2011
Oxytocin in the periaqueductal gray participates in pain modulation in the rat by influencing endogenous opiate peptides.
    Peptides, 2011, Volume: 32, Issue:6

    Topics: Animals; beta-Endorphin; Catheterization; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Microinjections; Naloxone; Narcotic Antagonists; Oxytocin; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Periaqueductal Gray; Radioimmunoassay; Rats; Rats, Sprague-Dawley

2011
Endogenous endomorphin-2 contributes to spinal ĸ-opioid antinociception.
    Pharmacology, 2012, Volume: 89, Issue:3-4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Dynorphins; Enkephalin, Methionine; Male; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord

2012
Decreased plasma methionine-enkephalin levels in cluster headache patients.
    American journal of therapeutics, 2012, Volume: 19, Issue:3

    Topics: Adult; Aminopeptidases; Blood Platelets; Case-Control Studies; Cluster Headache; Enkephalin, Methionine; Humans; Longitudinal Studies; Male; Middle Aged; Pain; Peptides; Time Factors

2012
Supraspinal peroxynitrite modulates pain signaling by suppressing the endogenous opioid pathway.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Aug-08, Volume: 32, Issue:32

    Topics: Analysis of Variance; Animals; Carrageenan; CD11b Antigen; Cell Line, Transformed; Chromatography, Liquid; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Electrochemical Techniques; Enkephalin, Methionine; Glial Fibrillary Acidic Protein; Humans; Hyperalgesia; Injections, Spinal; Male; Medulla Oblongata; Metalloporphyrins; Microinjections; Neuroglia; Neurons; Opioid Peptides; Pain; Pain Measurement; Peroxynitrous Acid; Phosphopyruvate Hydratase; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrosine

2012
Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2012, Volume: 26, Issue:12

    Topics: Alanine; Amino Acid Sequence; Animals; Antibodies; CD13 Antigens; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme Inhibitors; Flow Cytometry; Hindlimb; Inflammation; Leucine; Leukocytes; Male; Narcotic Antagonists; Neprilysin; Neurons; Opioid Peptides; Pain; Pain Threshold; Phosphinic Acids; Rats; Rats, Wistar; Receptors, Opioid; Thiorphan

2012
Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Jul-08, Volume: 100, Issue:14

    Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Methionine; Formaldehyde; Glycopeptides; Kidney; Leucine; Male; Membrane Proteins; Molecular Sequence Data; Naltrexone; Neprilysin; Pain; Pain Measurement; Prostate; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Salivary Proteins and Peptides; Spinal Cord; Submandibular Gland; Substance P; Thiorphan; Wounds and Injuries

2003
Different mechanisms of intrinsic pain inhibition in early and late inflammation.
    Journal of neuroimmunology, 2003, Volume: 141, Issue:1-2

    Topics: Animals; Corticotropin-Releasing Hormone; Dynorphins; Edema; Endorphins; Enkephalin, Methionine; Freund's Adjuvant; Hindlimb; Inflammation; Injections, Subcutaneous; Leukocytes; Male; Naloxone; Pain; Pain Threshold; Rats; Rats, Wistar; Stress, Physiological; Time Factors

2003
Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain--potential function of a novel receptor.
    British journal of pharmacology, 2004, Volume: 141, Issue:3

    Topics: Acute Disease; Animals; Dose-Response Relationship, Drug; Enkephalin, Methionine; Injections, Spinal; Male; Pain; Pain Measurement; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid

2004
The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat.
    European journal of pharmacology, 2004, Jun-16, Volume: 493, Issue:1-3

    Topics: Animals; Arthritis, Experimental; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Freund's Adjuvant; Injections, Intradermal; Injections, Intraperitoneal; Male; Morphine; Mycobacterium; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant

2004
Grafts of immortalized chromaffin cells bio-engineered to improve met-enkephalin release also reduce formalin-evoked c-fos expression in rat spinal cord.
    Neuroscience letters, 2004, Nov-03, Volume: 370, Issue:1

    Topics: Analysis of Variance; Animals; Cell Count; Cell Line, Transformed; Chromaffin Cells; Enkephalin, Methionine; Formaldehyde; Gene Expression Regulation; Genetic Engineering; Graft Survival; Humans; Immunohistochemistry; Male; Nerve Growth Factor; Pain; Phenylethanolamine N-Methyltransferase; Proto-Oncogene Proteins c-fos; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord; Transfection

2004
Effects of intrathecal BAM22 on noxious stimulus-evoked c-fos expression in the rat spinal dorsal horn.
    Brain research, 2004, Dec-03, Volume: 1028, Issue:2

    Topics: Animals; Cattle; Cell Count; Drug Interactions; Enkephalin, Methionine; Enkephalins; Formaldehyde; Gene Expression Regulation; Hot Temperature; Immunohistochemistry; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Pain; Pain Measurement; Physical Stimulation; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord

2004
Analgesic activity of enkephalins following intracerebral administration in the rat.
    Life sciences, 1977, Mar-01, Volume: 20, Issue:5

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Antagonism; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Male; Morphine; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Tail

1977
A new electrochemical HPLC method for analysis of enkephalins and endomorphins.
    Journal of neuroscience methods, 2006, Jan-15, Volume: 150, Issue:1

    Topics: Animals; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Male; Microdialysis; Oligopeptides; Pain; Perfusion; Posterior Horn Cells; Potassium Chloride; Rats; Rats, Sprague-Dawley; Stimulation, Chemical

2006
Synthesis, conformational and pharmacological studies of glycosylated chimeric peptides of Met-enkephalin and FMRFa.
    Brain research bulletin, 2006, Jan-30, Volume: 68, Issue:5

    Topics: Animals; Blood-Brain Barrier; Dose-Response Relationship, Drug; Drug Design; Drug Interactions; Enkephalin, Methionine; FMRFamide; Glycopeptides; Glycosylation; Mass Spectrometry; Mice; Oligopeptides; Pain; Pain Measurement; Protein Conformation; Reaction Time; Time Factors

2006
Genetically engineered human mesenchymal stem cells produce met-enkephalin at augmented higher levels in vitro.
    Cell transplantation, 2006, Volume: 15, Issue:3

    Topics: Analgesics; Analgesics, Opioid; Cell Proliferation; Cells, Cultured; DNA; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Gene Fusion; Genetic Engineering; Genetic Vectors; Green Fluorescent Proteins; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Pain; Protein Precursors; Reverse Transcriptase Polymerase Chain Reaction; Transfection

2006
Chimeric peptide of met-enkephalin and FMRFa: effect of chlorination on conformation and analgesia.
    Neuroscience letters, 2006, Jul-31, Volume: 403, Issue:1-2

    Topics: Analgesia; Analgesics, Opioid; Animals; Circular Dichroism; Enkephalin, Methionine; FMRFamide; Male; Mice; Octanols; Oligopeptides; Pain; Protein Structure, Secondary; Solubility; Water

2006
Arginine vasopressin induces periaqueductal gray release of enkephalin and endorphin relating to pain modulation in the rat.
    Regulatory peptides, 2007, Jul-05, Volume: 142, Issue:1-2

    Topics: Acetylcholine; Animals; Arginine Vasopressin; beta-Endorphin; Choline; Dopamine; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Epinephrine; gamma-Aminobutyric Acid; Glutamic Acid; Male; Norepinephrine; Opioid Peptides; Oxytocin; Pain; Pain Threshold; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Serotonin

2007
The involvement of spinal bovine adrenal medulla 22-like peptide, the proenkephalin derivative, in modulation of nociceptive processing.
    The European journal of neuroscience, 2007, Volume: 26, Issue:5

    Topics: Animals; Antibodies; Behavior, Animal; Disease Models, Animal; Enkephalin, Methionine; Freund's Adjuvant; Functional Laterality; Ganglia, Spinal; Gene Expression Regulation; Male; Neurons; Oncogene Proteins v-fos; Pain; Pain Measurement; Protein Precursors; Rats; Rhizotomy; Spinal Cord; Spinal Cord Injuries

2007
The enhancing effects of peptidase inhibitors on the antinociceptive action of [Met5]enkephalin-Arg6-Phe7 in rats.
    Journal of pharmacological sciences, 2007, Volume: 105, Issue:1

    Topics: Analgesics; Animals; Captopril; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, Methionine; Glycopeptides; Injections, Intraventricular; Injections, Subcutaneous; Male; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Peptides; Protease Inhibitors; Rats; Rats, Wistar

2007
Involvement of spinal Met-enkephalin in nicotine-induced antinociception in mice.
    Brain research, 2008, Jan-16, Volume: 1189

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Down-Regulation; Dynorphins; Enkephalin, Methionine; Enkephalins; Male; Mecamylamine; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nociceptors; Pain; Pain Measurement; Pain Threshold; Posterior Horn Cells; Pro-Opiomelanocortin; Protein Precursors; RNA, Messenger

2008
Experimental pain and neuropeptides.
    Clinical therapeutics, 1984, Volume: 7 Spec No

    Topics: Animals; Enkephalin, Methionine; Male; Morphine; Pain; Rabbits; Rats; Rats, Inbred Strains; Reticular Formation; Spinal Cord; Substance P

1984
Effect of neuroactive peptides on labeled 5-hydroxytryptamine release from rat spinal cord.
    Proceedings of the National Science Council, Republic of China. Part B, Life sciences, 1984, Volume: 8, Issue:2

    Topics: Animals; Baclofen; beta-Endorphin; Endorphins; Enkephalin, Methionine; Male; Naloxone; Neuropeptides; Neurotensin; Pain; Rats; Rats, Inbred Strains; Secretory Rate; Serotonin; Somatostatin; Spinal Cord; Substance P

1984
[The role of multiple opioid receptors and their ligands in pain modulation].
    Arzneimittel-Forschung, 1984, Volume: 34, Issue:9A

    Topics: Animals; Brain; Chronic Disease; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Pain; Receptors, Opioid; Spinal Cord

1984
Lack of interaction between methionine enkephalin and D-phenylalanine on nociceptive and non-nociceptive responses of dorsal horn neurones of the cat.
    European journal of pharmacology, 1984, Sep-17, Volume: 104, Issue:3-4

    Topics: Analgesia; Animals; Cats; Drug Interactions; Enkephalin, Methionine; Naloxone; Neurons; Pain; Phenylalanine; Receptors, Opioid; Reflex; Spinal Cord

1984
On the etiopathogenesis of migraine: a possible link between the amines and endorphin hypotheses.
    Advances in neurology, 1982, Volume: 33

    Topics: Adult; Clonidine; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Histamine; Humans; Male; Middle Aged; Migraine Disorders; Neurotransmitter Agents; Norepinephrine; Pain; Premedication; Prolactin; Sensory Thresholds; Serotonin; Substance Withdrawal Syndrome

1982
Effect on perception and reaction to pain in opiate analgesia.
    The Indian journal of medical research, 1983, Volume: 77

    Topics: Analgesia; Analgesics, Opioid; Animals; Behavior, Animal; Enkephalin, Methionine; Female; Male; Mice; Morphine; Naloxone; Pain

1983
Evidence for a role of the ventro-medial posterior hypothalamus in nociceptive processes in the rat.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 18, Issue:6

    Topics: Animals; beta-Endorphin; Dynorphins; Electroshock; Endorphins; Enkephalin, Methionine; Hypothalamus; Hypothalamus, Posterior; Male; Morphine; Naltrexone; Nociceptors; Pain; Protein Precursors; Rats; Rats, Inbred Strains; Stereotaxic Techniques

1983
Acupuncture relief of chronic pain syndrome correlates with increased plasma met-enkephalin concentrations.
    Lancet (London, England), 1983, Dec-17, Volume: 2, Issue:8364

    Topics: Acupuncture Therapy; beta-Endorphin; Chronic Disease; Endorphins; Enkephalin, Methionine; Female; Humans; Male; Mental Disorders; Pain; Pain Management; Syndrome

1983
Substance P, morphine and methionine-enkephalin: effects on spontaneous and evoked neuronal firing in the nucleus reticularis gigantocellularis of the rat.
    European journal of pharmacology, 1980, Oct-03, Volume: 67, Issue:1

    Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Medulla Oblongata; Morphine; Neurotransmitter Agents; Pain; Pressure; Rats; Substance P

1980
Differential effects of D-Ala2 analogues of enkephalins on substance P-induced analgesia in rodents.
    European journal of pharmacology, 1982, Aug-27, Volume: 82, Issue:3-4

    Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Pain; Rats; Rats, Inbred Strains; Substance P

1982
Cyclic AMP, morphine, met-enkephalin and neuronal firing.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 219, Issue:2

    Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Action Potentials; Animals; Cyclic AMP; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Mesencephalon; Morphine; Neurons; Pain; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains

1981
D-phenylalanine and other enkephalinase inhibitors as pharmacological agents: implications for some important therapeutic application.
    Substance and alcohol actions/misuse, 1982, Volume: 3, Issue:4

    Topics: Acupuncture Therapy; Animals; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Humans; Morphine; Morphine Dependence; Neprilysin; Nociceptors; Pain; Phenylalanine; Protease Inhibitors; Receptors, Opioid

1982
Pain control by endogenous enkephalins is mediated by mu opioid receptors.
    Life sciences, 1983, Volume: 33 Suppl 1

    Topics: Amino Acids, Sulfur; Analgesia; Animals; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; Pain; Protease Inhibitors; Receptors, Opioid; Receptors, Opioid, mu; Thiorphan; Tiopronin

1983
Afferent fibers mediate the increase of met-enkephalin elicited in rat spinal cord by localized pain.
    Pain, 1984, Volume: 18, Issue:1

    Topics: Afferent Pathways; Animals; Enkephalin, Methionine; Freund's Adjuvant; Inflammation; Male; Nerve Fibers; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Synaptic Transmission

1984
Localization of Met-enkephalin-like immunoreactivity within pain-related nuclei of cervical spinal cord, brainstem and midbrain in the cat.
    Brain research bulletin, 1983, Volume: 11, Issue:5

    Topics: Animals; Brain Stem; Cats; Enkephalin, Methionine; Histocytochemistry; Immunoenzyme Techniques; Mesencephalon; Neck; Olivary Nucleus; Pain; Periaqueductal Gray; Raphe Nuclei; Spinal Cord; Trigeminal Nucleus, Spinal

1983
Met-enkephalin-Arg6-Phe7-like immunoreactive substances mediate electroacupuncture analgesia in the periaqueductal gray of the rabbit.
    Brain research, 1984, Nov-26, Volume: 322, Issue:2

    Topics: Acupuncture Therapy; Animals; Brain Mapping; Captopril; Combined Modality Therapy; Electric Stimulation Therapy; Enkephalin, Methionine; Male; Naloxone; Pain; Pain Management; Periaqueductal Gray; Rabbits

1984
Normal CSF levels of met-enkephalin-like material in a case of naloxone-reversible congenital insensitivity to pain.
    Neuropeptides, 1984, Volume: 4, Issue:3

    Topics: Adult; Enkephalin, Methionine; Epilepsy; Female; Humans; Naloxone; Nociceptors; Pain; Reference Values; Skin

1984
Long latency spinal cord dorsum potential; suppression by intrathecal morphine and enkephalin analog.
    Brain research, 1984, Jun-25, Volume: 304, Issue:2

    Topics: Analgesics; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Enkephalin, Methionine; Evoked Potentials; Injections, Spinal; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Spinal Cord

1984
Inhibition of spontaneous and opiate-modified nociception by an endogenous neuropeptide with Phe-Met-Arg-Phe-NH2-like immunoreactivity.
    Proceedings of the National Academy of Sciences of the United States of America, 1984, Volume: 81, Issue:15

    Topics: Animals; Drug Tolerance; Enkephalin, Methionine; FMRFamide; Male; Morphine; Oligopeptides; Pain; Rats; Spinal Cord

1984
[Endogenous opiate peptides and quantification of surgical results in pain].
    Casopis lekaru ceskych, 1984, Jan-27, Volume: 123, Issue:4

    Topics: Electrocoagulation; Enkephalin, Methionine; Humans; Pain; Spinal Cord

1984
Effects of nitrous oxide exposure on Met-enkephalin levels in discrete areas of rat brain.
    Neuroscience letters, 1984, Mar-09, Volume: 45, Issue:1

    Topics: Animals; Brain Chemistry; Endorphins; Enkephalin, Methionine; Male; Nitrous Oxide; Pain; Radioimmunoassay; Rats; Rats, Inbred Strains; Tissue Distribution

1984
Prolonged intermittent footshock stress decreases Met and Leu enkephalin levels in brain with concomitant decreases in pain threshold.
    Life sciences, 1983, Jul-04, Volume: 33, Issue:1

    Topics: Animals; Body Temperature; Brain; Electroshock; Enkephalin, Leucine; Enkephalin, Methionine; Foot; Latency Period, Psychological; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Stress, Physiological

1983
[Effect of met- and leu-enkephalins and their synthetic analog on stimulation and acupunture analgesia].
    Biulleten' eksperimental'noi biologii i meditsiny, 1981, Volume: 92, Issue:8

    Topics: Acupuncture Therapy; Analgesia; Animals; Brain Stem; Electric Stimulation Therapy; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Pain; Pain Management; Rats

1981
The role of the pituitary in the diurnal variation in tolerance to painful stimuli and brain enkephalin levels.
    Life sciences, 1981, Nov-23, Volume: 29, Issue:21

    Topics: Animals; Brain; Circadian Rhythm; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; Hypophysectomy; Male; Mice; Naloxone; Pain; Pituitary Gland; Prolactin; Rats; Stress, Psychological

1981
Morphine and methionine-enkephalin: different effects on spontaneous and evoked neuronal firing in the mesencephalic reticular formation of the rat.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 213, Issue:2

    Topics: Action Potentials; Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Iontophoresis; Male; Mesencephalon; Morphine; Neurons; Pain; Rats; Reticular Formation

1980
[Met-enkephalin and substance P. Comparison of CSF levels in patients with chronic pain based on a sampling procedure].
    Revue neurologique, 1993, Volume: 149, Issue:6-7

    Topics: Adult; Aged; Chronic Disease; Enkephalin, Methionine; Female; Humans; Male; Middle Aged; Pain; Sampling Studies; Spinal Puncture; Substance P; Ventriculoperitoneal Shunt

1993
Changes of spinal substance P, calcitonin gene-related peptide, somatostatin, Met-enkephalin and neurotensin in rats in response to formalin-induced pain.
    Regulatory peptides, 1994, Apr-14, Volume: 51, Issue:1

    Topics: Animals; Calcitonin Gene-Related Peptide; Enkephalin, Methionine; Female; Formaldehyde; Image Processing, Computer-Assisted; Male; Microscopy, Electron; Neuropeptides; Neurotensin; Pain; Rats; Rats, Sprague-Dawley; Somatostatin; Spinal Cord; Substance P

1994
Changes in hypothalamic met-enkephalin levels of rats induced by painful stimulation and morphine treatment.
    Stereotactic and functional neurosurgery, 1993, Volume: 61, Issue:4

    Topics: Animals; Enkephalin, Methionine; Formaldehyde; Hypothalamus; Male; Morphine; Naloxone; Pain; Rats; Rats, Wistar; Stimulation, Chemical

1993
Interleukin 1 beta and corticotropin-releasing factor inhibit pain by releasing opioids from immune cells in inflamed tissue.
    Proceedings of the National Academy of Sciences of the United States of America, 1994, May-10, Volume: 91, Issue:10

    Topics: Analysis of Variance; Animals; Antibodies; beta-Endorphin; Corticotropin-Releasing Hormone; Cyclosporine; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Inflammation; Injections; Interleukin-1; Male; Naloxone; Pain; Rats; Rats, Wistar; Recombinant Proteins; Regression Analysis; Somatostatin

1994
Enkephalin antinociception in mice is mediated by delta 1- and delta 2-opioid receptors in the brain and spinal cord, respectively.
    European journal of pharmacology, 1993, Sep-28, Volume: 242, Issue:2

    Topics: Animals; Benzylidene Compounds; beta-Endorphin; Brain; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Injections, Spinal; Male; Mice; Naltrexone; Pain; Receptors, Opioid, delta; Spinal Cord

1993
Release into ventriculo-cisternal perfusate of beta-endorphin- and Met-enkephalin-immunoreactivity: effects of electrical stimulation in the arcuate nucleus and periaqueductal gray of the rat.
    Brain research, 1995, Sep-04, Volume: 690, Issue:2

    Topics: Animals; Arcuate Nucleus of Hypothalamus; beta-Endorphin; Cerebral Ventricles; Cisterna Magna; Electric Stimulation; Enkephalin, Methionine; Immunohistochemistry; Male; Pain; Pain Measurement; Perfusion; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reflex

1995
Basal release of Met-enkephalin and neurotensin in the ventrolateral periaqueductal gray matter of the rat: a microdialysis study of antinociceptive circuits.
    Brain research, 1995, Sep-04, Volume: 690, Issue:2

    Topics: Animals; Basal Metabolism; Bicuculline; Enkephalin, Methionine; Feedback; GABA Antagonists; Male; Microdialysis; Morphine; Neural Pathways; Neurotensin; Pain; Periaqueductal Gray; Rats; Rats, Sprague-Dawley

1995
Delta-Opioid receptor modulation of the release of substance P-like immunoreactivity in the dorsal horn of the rat following mechanical or thermal noxious stimulation.
    Brain research, 1996, Oct-14, Volume: 736, Issue:1-2

    Topics: Animals; Decerebrate State; Enkephalin, Methionine; Functional Laterality; Hindlimb; Hot Temperature; Male; Naltrexone; Narcotic Antagonists; Pain; Physical Stimulation; Rats; Rats, Wistar; Receptors, Opioid, delta; Spinal Cord; Substance P; Time Factors

1996
Increased cerebrospinal fluid concentration of aspartate but decreased concentration of nitric oxide breakdown products in women experiencing visceral pain during active labour.
    Neuroreport, 1997, Mar-03, Volume: 8, Issue:4

    Topics: Adult; Aged; Analgesia; Aspartic Acid; Cesarean Section; Delivery, Obstetric; Enkephalin, Methionine; Female; Humans; Labor, Obstetric; Metalloendopeptidases; Middle Aged; Nitric Oxide; Pain; Postmenopause; Pregnancy; Reference Values; Substance P

1997
[Met5]enkephalin and delta2-opioid receptors in the spinal cord are involved in the cold water swimming-induced antinociception in the mouse.
    Life sciences, 1997, Volume: 61, Issue:7

    Topics: Animals; beta-Endorphin; Cold Temperature; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord

1997
Antinociceptive and antidepressant-like profiles of BL-2401, a novel enkephalinase inhibitor, in mice and rats.
    Japanese journal of pharmacology, 1997, Volume: 75, Issue:4

    Topics: Administration, Oral; Analgesics; Analgesics, Opioid; Animals; Antidepressive Agents; Benzoates; Benzoquinones; Corpus Striatum; Curcumin; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, Methionine; Female; Hyperalgesia; Male; Mice; Naloxone; Narcotic Antagonists; Narcotics; Neprilysin; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sulfhydryl Compounds; Swimming

1997
Intrathecal implants of bovine chromaffin cells alleviate mechanical allodynia in a rat model of neuropathic pain.
    Pain, 1998, Volume: 76, Issue:1-2

    Topics: Animals; Behavior, Animal; Catecholamines; Cattle; Cell Transplantation; Chromaffin Cells; Enkephalin, Methionine; Male; Neuropeptides; Pain; Pain Management; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord; Transplantation, Heterologous

1998
Centrally applied NPY mimics immunoactivation induced by non-analgesic doses of met-enkephalin.
    Neuroreport, 1998, Dec-01, Volume: 9, Issue:17

    Topics: Adjuvants, Immunologic; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Methionine; Injections, Intraventricular; Male; Neuropeptide Y; Pain; Rats; Rats, Inbred Lew

1998
Effects of peptidase inhibitors on the enkephalin-induced anti-nociception in rats.
    Japanese journal of pharmacology, 1998, Volume: 78, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Captopril; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enkephalin, Methionine; Glycopeptides; Injections, Intraventricular; Injections, Subcutaneous; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Peptides; Protease Inhibitors; Rats; Rats, Wistar

1998
Central changes in nociceptin dynorphin B and Met-enkephalin-Arg-Phe in different models of nociception.
    Brain research, 2000, Feb-28, Volume: 857, Issue:1-2

    Topics: Animals; Brain; Dynorphins; Efferent Pathways; Endorphins; Enkephalin, Methionine; Inflammation; Male; Nerve Crush; Nociceptin; Nociceptors; Opioid Peptides; Pain; Rats; Rats, Sprague-Dawley

2000
Generation and initial characterization of conditionally immortalized chromaffin cells.
    Journal of cellular biochemistry, 2000, Jul-19, Volume: 79, Issue:1

    Topics: Adrenal Glands; Animals; Catecholamines; Cattle; Cell Differentiation; Cell Line, Transformed; Chromaffin Cells; Chromatography, High Pressure Liquid; Colforsin; Dexamethasone; Dopamine beta-Hydroxylase; Enkephalin, Methionine; Female; Hot Temperature; Humans; Immunohistochemistry; Pain; Pain Management; Peripheral Nerve Injuries; Phenylethanolamine N-Methyltransferase; Rats; Spinal Cord Injuries; Tyrosine 3-Monooxygenase

2000
Involvement of dynorphin in immobilization stress-induced antinociception in the mouse.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2000, Volume: 10, Issue:5

    Topics: Animals; beta-Endorphin; Cerebral Ventricles; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Reaction Time; Restraint, Physical; Stress, Psychological

2000
Absence of spinal response to extracorporeal shock waves on the endogenous opioid systems in the rat.
    Ultrasound in medicine & biology, 2001, Volume: 27, Issue:2

    Topics: Animals; Chi-Square Distribution; Dynorphins; Enkephalin, Methionine; Immunohistochemistry; Lithotripsy; Pain; Rats; Rats, Wistar; Spinal Cord

2001
Antisera against endogenous opioids increase the nocifensive response to formalin: demonstration of inhibitory beta-endorphinergic control.
    European journal of pharmacology, 2001, Jun-01, Volume: 421, Issue:1

    Topics: Animals; beta-Endorphin; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Formaldehyde; Immune Sera; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Nociceptors; Opioid Peptides; Pain

2001
Effects of intracerebroventricularly administered chimeric peptide of metenkephalin and FMRFa--[D-Ala2]YFa-on antinociception and its modulation in mice.
    Brain research bulletin, 2001, May-01, Volume: 55, Issue:1

    Topics: Analgesics, Opioid; Animals; Brain; Drug Interactions; Enkephalin, Methionine; FMRFamide; Injections, Intraventricular; Mice; Mice, Inbred Strains; Morphine; Naloxone; Narcotic Antagonists; Neurons; Nociceptors; Oligopeptides; Pain; Pain Measurement; Recombinant Fusion Proteins

2001
Methionine-enkephalin-and Dynorphin A-release from immune cells and control of inflammatory pain.
    Pain, 2001, Volume: 93, Issue:3

    Topics: Animals; Antibodies; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Methionine; Humans; Inflammation; Interleukin-2; Lymphocytes; Male; Pain; Rats; Rats, Wistar

2001
Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse.
    European journal of pharmacology, 2001, Sep-21, Volume: 427, Issue:3

    Topics: Analgesics; Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Time Factors

2001
Alteration in endogenous opioid systems due to chronic inflammatory pain conditions.
    European journal of pharmacology, 2002, Jan-25, Volume: 435, Issue:2-3

    Topics: Animals; Brain; Chronic Disease; Disease Models, Animal; Dynorphins; Endorphins; Enkephalin, Methionine; Female; Inflammation; Opioid Peptides; Pain; Pain Measurement; Rats; Rats, Inbred Lew; Receptors, Opioid; Spinal Cord

2002
Intrathecal cholecystokinin octapeptide attenuates the antinociception and release of immunoreactive Met-enkephalin induced by intraventricular beta-endorphin in the rat.
    Neuropeptides, 1992, Volume: 21, Issue:3

    Topics: Animals; beta-Endorphin; Depression, Chemical; Enkephalin, Methionine; Injections, Intraventricular; Injections, Spinal; Narcotic Antagonists; Pain; Proglumide; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Reflex; Secretory Rate; Sincalide; Spinal Cord; Tail

1992
Involvement of opioid receptors in Met-enkephalin modulation of blast-transformation of mouse splenocytes.
    Immunology letters, 1992, Volume: 32, Issue:1

    Topics: Animals; Binding, Competitive; Concanavalin A; Diprenorphine; Enkephalin, Methionine; Enterotoxins; Female; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Naloxone; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sensory Thresholds; Spleen

1992
Effects of the subcutaneous administration of enkephalins on tail-flick response and righting reflex of developing rats.
    Brain research. Developmental brain research, 1992, Oct-23, Volume: 69, Issue:2

    Topics: Aging; Animals; Anti-Bacterial Agents; Captopril; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Female; Glycopeptides; Injections, Subcutaneous; Male; Oligopeptides; Pain; Peptides; Posture; Protease Inhibitors; Rats; Rats, Wistar; Reflex

1992
Prolonged inflammatory pain modifies corticotropin-releasing factor-induced opioid peptide release in the hypothalamus.
    Brain research, 1991, Nov-01, Volume: 563, Issue:1-2

    Topics: Animals; Arthritis, Experimental; Behavior, Animal; beta-Endorphin; Corticotropin-Releasing Hormone; Dynorphins; Electroshock; Endorphins; Enkephalin, Methionine; Hypothalamus; In Vitro Techniques; Inflammation; Male; Pain; Potassium Chloride; Radioimmunoassay; Rats; Rats, Inbred Strains; Restraint, Physical; Stress, Psychological

1991
Enkephalinergic synaptic axon terminals on serotoninergic neurons in the dorsal raphe nucleus of the rat: an electron microscopic study by the double immunostaining method.
    Neuroscience letters, 1991, Mar-11, Volume: 124, Issue:1

    Topics: Animals; Axons; Enkephalin, Methionine; Male; Microscopy, Immunoelectron; Nerve Endings; Pain; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin; Synapses

1991
Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:15

    Topics: Animals; Antibodies, Monoclonal; beta-Endorphin; Dynorphins; Enkephalin, Methionine; Freund's Adjuvant; Immunoenzyme Techniques; Inflammation; Male; Neurons, Afferent; Pain; Physical Exertion; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Opioid; Reference Values; Skin

1990
Effects of single nanoinjections of Met-enkephalin in the minimally anesthetized rat brainstem on trigeminal nuclear neurons: differential effects on spontaneous versus evoked activity and noci-evoked versus innocuously-evoked responses.
    Brain research, 1991, Feb-15, Volume: 541, Issue:2

    Topics: Anesthesia; Animals; Behavior, Animal; Brain Stem; Electrophysiology; Enkephalin, Methionine; Evoked Potentials; Male; Microelectrodes; Microinjections; Neurons; Pain; Periaqueductal Gray; Raphe Nuclei; Rats; Rats, Inbred Strains; Reticular Formation; Trigeminal Nuclei

1991
Opioid peptides as possible cause of pain reduction in neuroblastoma after admission of 131I-meta-iodobenzylguanidine.
    Progress in clinical and biological research, 1991, Volume: 366

    Topics: 3-Iodobenzylguanidine; Antineoplastic Agents; beta-Endorphin; Child; Child, Preschool; Enkephalin, Methionine; Humans; Iodine Radioisotopes; Iodobenzenes; Neuroblastoma; Pain; Time Factors

1991
Increase in plasma methionine-enkephalin levels during the pain attack in episodic cluster headache.
    Cephalalgia : an international journal of headache, 1990, Volume: 10, Issue:5

    Topics: Adult; Cluster Headache; Enkephalin, Methionine; Epinephrine; Female; Humans; Male; Middle Aged; Norepinephrine; Pain; Time Factors

1990
Subcutaneous formalin induces a segmental release of Met-enkephalin-like material from the rat spinal cord.
    Pain, 1990, Volume: 41, Issue:3

    Topics: Animals; Enkephalin, Methionine; Formaldehyde; Injections, Subcutaneous; Lumbosacral Region; Male; Neck; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Stimulation, Chemical

1990
[The role of humoral factors in the mechanism of the analgesic effect of electroacupuncture].
    Anaesthesiologie und Reanimation, 1990, Volume: 15, Issue:3

    Topics: Animals; Dinoprost; Dogs; Electroacupuncture; Enkephalin, Leucine; Enkephalin, Methionine; Histamine; Pain; Serotonin

1990
Effects of opioids and opioid peptide on the release of substance P-like material induced by tooth pulp stimulation in the trigeminal nucleus caudalis of the rabbit.
    European journal of pharmacology, 1986, Oct-07, Volume: 129, Issue:3

    Topics: Animals; Dental Pulp; Electric Stimulation; Enkephalin, Methionine; Male; Morphine; Naloxone; Pain; Rabbits; Substance P; Trigeminal Nuclei

1986
Enkephalins interact with substance P-induced aversive behaviour in mice.
    Brain research, 1988, Feb-23, Volume: 442, Issue:1

    Topics: Animals; beta-Endorphin; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Methionine; Injections, Spinal; Mice; Nociceptors; Pain; Reaction Time; Substance P

1988
Chronic chlorimipramine does not reverse the reduction of cerebrospinal fluid Met-enkephalin-like immunoreactivity in chronic-pain patients.
    Clinical neuropharmacology, 1987, Volume: 10, Issue:5

    Topics: Adult; Aged; Chronic Disease; Clomipramine; Enkephalin, Methionine; Enkephalins; Female; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Pain; Radioimmunoassay; Serotonin

1987
Long-lasting neurochemical and functional changes in rats induced by neonatal administration of substance P antiserum.
    Brain research, 1989, Apr-24, Volume: 485, Issue:2

    Topics: Animals; Animals, Newborn; Antibodies; Blood Pressure; Enkephalin, Methionine; Hydroxyindoleacetic Acid; Male; Pain; Periaqueductal Gray; Rats; Rats, Inbred Strains; Spinal Cord; Substance P

1989
Further evidence for possible analgesic mechanism of electroacupuncture: effects on neuropeptides and serotonergic neurons in rat spinal cord.
    Japanese journal of pharmacology, 1989, Volume: 49, Issue:2

    Topics: Acupuncture Therapy; Analgesia, Epidural; Animals; Baclofen; Electric Stimulation; Enkephalin, Methionine; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Serotonin; Spinal Cord; Substance P

1989
Effects of phentolamine and propranolol on the changes of pain threshold and contents of MEK and LEK in rat brain after EA.
    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 1989, Volume: 9, Issue:3

    Topics: Animals; Brain; Electroacupuncture; Enkephalin, Leucine; Enkephalin, Methionine; Male; Pain; Phentolamine; Propranolol; Rats; Sensory Thresholds

1989
Segmental release of Met-enkephalin-like material from the spinal cord of rats, elicited by noxious thermal stimuli.
    Brain research, 1989, Apr-10, Volume: 484, Issue:1-2

    Topics: Animals; Enkephalin, Methionine; Hot Temperature; Male; Pain; Rats; Rats, Inbred Strains; Spinal Cord

1989
Spinal cord dynorphin may modulate nociception via a kappa-opioid receptor in chronic arthritic rats.
    Brain research, 1985, Aug-05, Volume: 340, Issue:1

    Topics: Animals; Arthritis; Chronic Disease; Conditioning, Classical; Dynorphins; Enkephalin, Methionine; Mycobacterium Infections; Naloxone; Nociceptors; Pain; Radioimmunoassay; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord

1985
Naloxone-reversible and non-reversible shock-induced analgesia during development.
    Neuroscience letters, 1985, Oct-10, Volume: 60, Issue:3

    Topics: Analgesia; Animals; beta-Endorphin; Central Nervous System; Dynorphins; Electroshock; Endorphins; Enkephalin, Methionine; Male; Naloxone; Pain; Rats; Rats, Inbred Strains

1985
[Peripheral analgesic actions of opioid peptides and morphine analogues].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1986, Volume: 88, Issue:2

    Topics: Analgesics, Opioid; Animals; Cyclazocine; Dynorphins; Enkephalin, Methionine; Ethylketocyclazocine; Levallorphan; Lidocaine; Male; Mice; Morphine; Naloxone; Pain; Peptide Fragments

1986
Spinal antinociceptive action of three representative opioid peptides in frogs.
    Brain research, 1987, Jan-27, Volume: 402, Issue:1

    Topics: Analgesics; Animals; beta-Endorphin; Dynorphins; Endorphins; Enkephalin, Methionine; Pain; Rana pipiens; Sensory Thresholds; Spinal Cord

1987
Time-dependent neurobiological effects of colchicine administered directly into the hippocampus of rats.
    Brain research, 1987, Apr-07, Volume: 408, Issue:1-2

    Topics: Acoustic Stimulation; Animals; Avoidance Learning; Behavior, Animal; Colchicine; Dynorphins; Enkephalin, Methionine; Hippocampus; Male; Motor Activity; Pain; Peptide Fragments; Rats; Rats, Inbred F344; Reaction Time; Reflex, Startle; Time Factors

1987
Pharmacologic consequences of the vascular permeability of chromaffin cell transplants in CNS pain modulatory regions.
    Experimental neurology, 1988, Volume: 102, Issue:3

    Topics: Adrenal Medulla; Analgesics; Animals; Blood-Brain Barrier; Capillary Permeability; Central Nervous System; Chromaffin System; Enkephalin, Methionine; Ganglionic Blockers; Ganglionic Stimulants; Male; Narcotic Antagonists; Pain; Rats; Rats, Inbred Strains

1988
Importance of generalized defective perception of painful stimuli as a cause of silent myocardial ischemia in chronic stable angina pectoris.
    The American journal of cardiology, 1986, Oct-01, Volume: 58, Issue:9

    Topics: Angina Pectoris; beta-Endorphin; Chronic Disease; Coronary Disease; Endorphins; Enkephalin, Methionine; Humans; Male; Middle Aged; Norepinephrine; Pain; Perception; Sensory Thresholds

1986
Effect of chronic morphine on plasma and brain beta endorphin and methionine enkephalin in pregnant rats and in their fetuses or newborn.
    Neuroendocrinology, 1988, Volume: 47, Issue:2

    Topics: Animals; Animals, Newborn; beta-Endorphin; Brain; Enkephalin, Methionine; Female; Fetus; Hypothalamus; Morphine; Pain; Pituitary Gland; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains

1988
Endorphins: "opiates for the masses".
    Medicine and science in sports and exercise, 1985, Volume: 17, Issue:1

    Topics: Acupuncture Therapy; Adrenocorticotropic Hormone; beta-Endorphin; Catecholamines; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalin, Methionine; Growth Hormone; Humans; Luteinizing Hormone; Naloxone; Pain; Physical Exertion; Receptors, Opioid; Sensory Thresholds; Stress, Physiological

1985
Spontaneous and evoked release of methionine-enkephalin-like material from the rat spinal cord in vivo.
    Brain research, 1985, Jul-29, Volume: 339, Issue:2

    Topics: Animals; Chromatography, Gel; Chromatography, High Pressure Liquid; Enkephalin, Methionine; Male; Pain; Potassium; Rats; Rats, Inbred Strains; Spinal Cord; Synaptic Transmission

1985
Involvement of different opioid receptor subtypes in electric shock-induced analgesia and motor suppression in the rat.
    European journal of pharmacology, 1985, Aug-15, Volume: 114, Issue:2

    Topics: Animals; Cyclazocine; Electroshock; Enkephalin, Methionine; Ethylketocyclazocine; Male; Motor Activity; Naloxone; Pain; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Opioid; Time Factors

1985
ACTH, beta-endorphin and met-enkephalin: peripheral modifications during the stress of human labor.
    Psychoneuroendocrinology, 1985, Volume: 10, Issue:3

    Topics: Adrenocorticotropic Hormone; Adult; Anxiety; beta-Endorphin; beta-Lipotropin; Endorphins; Enkephalin, Methionine; Female; Humans; Labor, Obstetric; Pain; Pregnancy; Stress, Physiological

1985
Electric footshock-induced changes in behavior and opioid receptor function.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 23, Issue:5

    Topics: Analgesia; Animals; Behavior, Animal; Binding, Competitive; Electroshock; Enkephalin, Methionine; Kinetics; Male; Motor Activity; Naloxone; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Sensory Thresholds; Synaptic Membranes

1985
[Analgesic effect of metorphamide on skin pain and visceral pain].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1986, Volume: 7, Issue:1

    Topics: Analgesics; Animals; Enkephalin, Methionine; Female; Male; Mice; Morphine; Naloxone; Pain; Rabbits; Receptors, Opioid; Receptors, Opioid, mu; Sensory Thresholds

1986
Inhibition of stress-induced hyperglycemia by tail pinching or intraventricular enkephalin administration in the rat.
    Brain research, 1988, Jun-14, Volume: 452, Issue:1-2

    Topics: Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Methionine; Hyperglycemia; Injections, Intraventricular; Insulin; Male; Naloxone; Pain; Rats; Rats, Inbred Strains; Restraint, Physical; Tail

1988
Effects of D-Met2, Pro5-enkephalinamide on pain tolerance and some cognitive functions in man.
    Psychopharmacology, 1986, Volume: 89, Issue:4

    Topics: Adult; Attention; Codeine; Cognition; Enkephalin, Methionine; Humans; Male; Memory; Memory, Short-Term; Middle Aged; Pain; Sensory Thresholds

1986
Influence of Y-20003, an analgesic agent, on the endogenous opioid peptide system in rats.
    NIDA research monograph, 1986, Volume: 75

    Topics: Adrenal Medulla; Aminoquinolines; Animals; Arthritis, Experimental; Endorphins; Enkephalin, Methionine; Kinetics; Male; Pain; Rats; Rats, Inbred Lew

1986
Intraventricular administration of BAM-18: antinociceptive and locomotor activity in the rat.
    NIDA research monograph, 1986, Volume: 75

    Topics: Analgesia; Animals; Cerebral Ventricles; Enkephalin, Methionine; Male; Motor Activity; Pain; Protein Precursors; Rats; Rats, Inbred Strains

1986
Increase in met-enkephalin level and antinociceptive effects induced by kelatorphan in the rat spinal cord.
    NIDA research monograph, 1986, Volume: 75

    Topics: Analgesics; Animals; Dipeptides; Enkephalin, Methionine; In Vitro Techniques; Leucine; Neurons; Pain; Rats; Spinal Cord; Thiorphan; Tiopronin

1986
[Influence of electroacupuncture and antagonism of electroacupuncture analgesia by naloxone on enkephalin-like immunoreactivity in guinea pig's adrenal and spinal cord].
    Zhen ci yan jiu = Acupuncture research, 1988, Volume: 13, Issue:3

    Topics: Acupuncture Therapy; Adrenal Glands; Analgesia; Animals; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; Immunohistochemistry; Male; Naloxone; Pain; Sensory Thresholds; Spinal Cord

1988
The effect of non-steroidal anti-inflammatory therapy on plasma neuropeptide concentrations in patients with osteoarthritis.
    British journal of rheumatology, 1985, Volume: 24, Issue:1

    Topics: Aged; Anti-Inflammatory Agents; beta-Endorphin; Delayed-Action Preparations; Endorphins; Enkephalin, Methionine; Female; Humans; Indomethacin; Male; Middle Aged; Osteoarthritis; Pain

1985
Changes in plasma opioid concentrations after physiotherapeutic exercises for arthritic patients.
    Neuropeptides, 1985, Volume: 5, Issue:4-6

    Topics: Adult; Aged; Arthritis; beta-Endorphin; Chronic Disease; Endorphins; Enkephalin, Methionine; Exercise Therapy; Female; Humans; Male; Middle Aged; Pain; Pain Management

1985
2S,3R 3-amino-2-hydroxy-4-phenylbutanoic acid derivatives, enkephalinase inhibitors, augment met5-enkephalin-induced antinociception.
    Japanese journal of pharmacology, 1988, Volume: 46, Issue:3

    Topics: Analgesics; Animals; Drug Synergism; Enkephalin, Methionine; Leucine; Male; Metalloendopeptidases; Mice; Mice, Inbred Strains; Neprilysin; Pain; Phenylbutyrates; Sensory Thresholds

1988
[Influence of captopril on the in vitro and in vivo effects of leu- and met-enkephalins].
    Biulleten' eksperimental'noi biologii i meditsiny, 1987, Volume: 103, Issue:6

    Topics: Animals; Captopril; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Enkephalin, Leucine; Enkephalin, Methionine; Female; Guinea Pigs; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Pain; Time Factors

1987
Spontaneous and evoked release of met-enkephalin-like material from the spinal cord of arthritic rats in vivo.
    Pain, 1988, Volume: 32, Issue:1

    Topics: Animals; Arthritis; Arthritis, Experimental; Enkephalin, Methionine; Male; Pain; Rats; Rats, Inbred Strains; Spinal Cord

1988
Circadian fluctuations in pain responsiveness and brain Met-enkephalin-like immunoreactivity in the rat.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 29, Issue:3

    Topics: Animals; Brain; Circadian Rhythm; Enkephalin, Methionine; Male; Pain; Rats; Rats, Inbred Strains; Tissue Distribution

1988
[D-Met2,Pro5] enkephalin [N1.5-beta-D-glucopyranosyl] amide: a glycosylpeptide with high antinociceptive activity.
    International journal of peptide and protein research, 1988, Volume: 31, Issue:5

    Topics: Analgesics; Animals; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Indicators and Reagents; Male; Mice; Mice, Inbred ICR; Morphine; Muscle Contraction; Muscle, Smooth; Pain; Rats; Rats, Inbred Strains; Structure-Activity Relationship

1988
Do enkephalins in basal ganglia mediate a physiological motor rest mechanism?
    Movement disorders : official journal of the Movement Disorder Society, 1986, Volume: 1, Issue:4

    Topics: Animals; Basal Ganglia; Biogenic Monoamines; Burns; Dopamine; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Locomotion; Male; Pain; Rats; Rats, Inbred Strains; Rest; Sensory Thresholds; Time Factors

1986
The response of individual nucleus raphe magnus neurons to microinjections of met-enkephalin at midbrain and at bulbar loci: evidence for midbrain-bulbar convergence on individual raphe neurons.
    The International journal of neuroscience, 1987, Volume: 33, Issue:3-4

    Topics: Action Potentials; Animals; Brain Mapping; Enkephalin, Methionine; Male; Medulla Oblongata; Neural Pathways; Pain; Periaqueductal Gray; Raphe Nuclei; Rats; Rats, Inbred Strains

1987
Medullary substrates of descending spinal inhibition activated by intravenous administration of [D-Ala2]methionine enkephalinamide in the rat.
    Brain research, 1987, May-19, Volume: 411, Issue:2

    Topics: Anesthetics, Local; Animals; Blood Pressure; Efferent Pathways; Enkephalin, Methionine; Heart Rate; Male; Medulla Oblongata; Neural Inhibition; Pain; Raphe Nuclei; Rats; Rats, Inbred Strains; Reticular Formation; Spinal Cord; Vagus Nerve

1987
Involvement of the dorsolateral funiculi in the spinal release of Met-enkephalin-like material triggered by heterosegmental noxious mechanical stimuli.
    Brain research, 1987, May-26, Volume: 412, Issue:1

    Topics: Animals; Enkephalin, Methionine; Pain; Physical Stimulation; Radioimmunoassay; Rats; Spinal Cord

1987
Peripheral effects of opioid drugs on capsaicin-sensitive neurones of the guinea-pig bronchus and rabbit ear.
    Naunyn-Schmiedeberg's archives of pharmacology, 1987, Volume: 336, Issue:3

    Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Bronchi; Capsaicin; Ear, External; Enkephalin, Methionine; Female; Fentanyl; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Narcotics; Neurons; Pain; Rabbits

1987
[Analgesia induced by morphine administered to the nucleus accumbens was blocked by naloxone or [Met5] enkephalin antiserum injected into the periaqueductal gray of the rabbit].
    Sheng li xue bao : [Acta physiologica Sinica], 1987, Volume: 39, Issue:4

    Topics: Analgesia; Animals; Efferent Pathways; Enkephalin, Methionine; Immune Sera; Male; Microinjections; Morphine; Naloxone; Nucleus Accumbens; Pain; Periaqueductal Gray; Rabbits; Sensory Thresholds; Septal Nuclei

1987
Low doses of naloxone produce analgesia in the mouse brain by blocking presynaptic autoinhibition of enkephalin release.
    Neuroscience letters, 1986, Apr-24, Volume: 65, Issue:3

    Topics: Analgesia; Animals; Brain Chemistry; Dose-Response Relationship, Drug; Enkephalin, Methionine; Male; Mice; Naloxone; Neural Inhibition; Pain; Rats; Rats, Inbred Strains; Time Factors

1986
Opiate microinjections into midbrain do not affect the aversiveness of caudal trigeminal stimulation but produce somatotopically organized peripheral hypoalgesia.
    Brain research, 1986, Sep-24, Volume: 383, Issue:1-2

    Topics: Animals; Enkephalin, Methionine; Hot Temperature; Male; Morphine; Pain; Periaqueductal Gray; Rats; Reticular Formation; Sensory Thresholds; Trigeminal Nucleus, Spinal

1986
Noxious mechanical stimuli increase the release of Met-enkephalin-like material heterosegmentally in the rat spinal cord.
    Brain research, 1987, Jan-27, Volume: 402, Issue:1

    Topics: Animals; Enkephalin, Methionine; Neural Inhibition; Pain; Potassium; Radioimmunoassay; Rats; Spinal Cord; Trigeminal Caudal Nucleus; Trigeminal Nucleus, Spinal

1987
Antinociceptive effects of intrathecal opioids, noradrenaline and serotonin in rats: mechanical and thermal algesic tests.
    Brain research, 1985, Feb-04, Volume: 326, Issue:1

    Topics: Analgesics; Animals; Enkephalin, Methionine; Injections, Spinal; Male; Morphine; Norepinephrine; Pain; Rats; Rats, Inbred Strains; Serotonin

1985
[Investigations on the relationship between methionine-enkephalin (Met-Enk) and acetylcholine (ACh) in brain of rats, with their influence on the effect of electroacupuncture analgesia].
    Zhen ci yan jiu = Acupuncture research, 1985, Volume: 10, Issue:2

    Topics: Acetylcholine; Acupuncture Therapy; Animals; Brain Chemistry; Electric Stimulation Therapy; Enkephalin, Methionine; Female; Male; Pain; Radioimmunoassay; Rats; Sensory Thresholds; Transcutaneous Electric Nerve Stimulation

1985
Prefrontal influences upon the midbrain: a possible route for pain modulation.
    Brain research, 1985, Jul-29, Volume: 339, Issue:2

    Topics: Acetylcholine; Analgesia; Animals; Brain Mapping; Enkephalin, Methionine; Frontal Lobe; Neural Pathways; Norepinephrine; Pain; Rats; Rats, Inbred Strains; Reaction Time

1985
Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain.
    Journal of medicinal chemistry, 2015, Nov-12, Volume: 58, Issue:21

    Topics: Amino Acid Sequence; Analgesics; Animals; HEK293 Cells; Humans; Male; Mice; Neurokinin-1 Receptor Antagonists; Pain; Peptides; Rats; Receptors, Neurokinin-1; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship

2015
A novel [5.2.1]bicyclic amine is a potent analgesic without µ opioid activity.
    Bioorganic & medicinal chemistry letters, 2021, 03-15, Volume: 36

    Topics: Acetic Acid; Amines; Analgesics; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Mice; Mice, Inbred Strains; Molecular Structure; Pain; Pain Measurement; Structure-Activity Relationship

2021