enkephalin, methionine has been researched along with Pain in 146 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 75 (51.37) | 18.7374 |
| 1990's | 25 (17.12) | 18.2507 |
| 2000's | 31 (21.23) | 29.6817 |
| 2010's | 12 (8.22) | 24.3611 |
| 2020's | 3 (2.05) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, D; Fang, Q; Hu, X; Li, N; Shi, Y; Xu, B; Zhang, M; Zhang, N; Zhang, Q; Zhang, R | 1 |
| Cheng, W; Hu, J; Huang, S; Sun, S; Tian, F | 1 |
| Baamonde, A; Cernuda-Cernuda, R; Fernández-García, MT; Folgueras, AR; García-Domínguez, M; Hidalgo, A; Lastra, A; Menéndez, L | 1 |
| Aloisi, AM; Ashrafi, M; Pirzadeh, S; Sajedianfard, J | 1 |
| Chavarría-Bolaños, D; Flores-Reyes, H; Lombana, N; Martinez-Zumaran, A; Pozos-Guillen, A | 1 |
| Eichenbaum, H; Karom, MC; Murphy, AZ; Victoria, NC | 1 |
| Li, D; Li, H | 1 |
| Chung, E; Ohgami, Y; Quock, RM; Shirachi, DY; Zelinski, LM | 1 |
| Westlund, KN | 1 |
| Brack, A; Hackel, D; Labuz, D; Mousa, S; Rittner, HL; Schaefer, M; Schäfer, M; Stein, C; Stolz, A; Voigt, P | 1 |
| Hino, M; Horiuchi, H; Morino, T; Ogata, T; Yamamoto, H | 1 |
| Chu, J; Lin, BC; Liu, WY; Wang, G; Xu, H; Yang, J; Yang, Y; Yuan, H | 1 |
| Bourgoin, S; Cesselin, F; Hamon, M; Le Bars, D; Mauborgne, A | 1 |
| Fu, Y; Hong, YG; Jiang, JP | 1 |
| Hao, F; Li, P; Liang, JY; Pan, YJ; Qiu, PY; Wang, DX; Yang, J; Zhang, J | 1 |
| Shimoyama, M; Shimoyama, N; Tagaito, Y; Toyama, S | 1 |
| Maturana, P; Mosnaim, AD; Puente, J; Wolf, ME | 1 |
| Bryant, L; Chen, Z; Doyle, T; Ghaffari, M; Little, JW; Neumann, WL; Porreca, F; Salvemini, D | 1 |
| Fournie-Zaluski, MC; Gore, C; Labuz, D; Machelska, H; Roques, BP; Schreiter, A; Stein, C | 1 |
| Blisnick, T; Desor, D; Dugave, C; Hermitte, V; Messaoudi, M; Rigault, AG; Rougeon, F; Rougeot, C | 1 |
| Labuz, D; Machelska, H; Mousa, SA; Schäfer, M; Schopohl, JK; Stein, C | 1 |
| Dai, P; Hong, Y; Jiang, J; Zeng, X | 1 |
| Cox, ML; Welch, SP | 1 |
| Duplan, H; Eaton, MJ; Emorine, L; Herman, JP; Lazorthes, Y; Li, RY; Tafani, M; Vue, C; Zhou, H | 1 |
| Hong, Y; Huang, H; Zeng, X | 1 |
| Baraniuk, JN; Clauw, DJ; Cunningham, J; Whalen, G | 1 |
| Goldstein, JM; Malick, JB | 1 |
| Lisi, TL; Sluka, KA | 1 |
| Ahsan, A; Hanif, K; Maiti, S; Masand, G; Pasha, S; Sen, S | 1 |
| Pappas, GD; Qu, T; Sugaya, I; Sugaya, K | 1 |
| Gupta, K; Gupta, S; Gupta, YK; Hanif, K; Maiti, S; Pasha, S | 1 |
| Chen, JM; Lin, BC; Liu, WY; Xu, HT; Yang, J; Yang, Y | 1 |
| Cai, M; Chen, T; Hong, Y; Quirion, R | 1 |
| Jin, XL; Kobayashi, H; Kosaka, K; Oka, T; Takahashi, S; Yoshikawa, M | 1 |
| Kiguchi, N; Kishioka, S; Maeda, T; Ozaki, M; Tsuruga, M; Yamamoto, A; Yamamoto, C | 1 |
| Takagi, H | 1 |
| Tsai, HY | 1 |
| Herz, A | 1 |
| Duggan, AW; Foong, FW; Zhao, ZQ | 1 |
| Agnoli, A; Ceci, E; Denaro, A; Falaschi, P | 1 |
| Bhargava, KP; Nath, C; Pant, KK; Sinha, JN | 1 |
| Herz, A; Millan, MH; Millan, MJ; Przewłocki, R | 1 |
| Altshuler, KZ; Bhatia, K; Gatchel, RJ; Huang, XY; Khatami, MJ; Kiser, RS | 1 |
| Quirion, R | 1 |
| Haigler, HJ; Spring, DD | 1 |
| Del Rio, J; Naranjo, JR | 1 |
| Haigler, HJ; Hosford, DA | 2 |
| Ehrenpreis, S | 1 |
| Chaillet, P; Costentin, J; Coulaud, A; Fournié-Zaluski, MC; Gacel, G; Roques, BP | 1 |
| Covelli, V; Faccini, E; Govoni, S; Missale, C; Spano, PF; Trabucchi, M; Uzumaki, H | 1 |
| Arluison, M; Bourgoin, S; Cesselin, F; Conrath-Verrier, M; Dietl, M; Hamon, M | 1 |
| Fei, H; Han, JS; Zhou, ZF | 1 |
| Artaud, F; Bourgoin, S; Cesselin, F; Hamon, M; Montastruc, JL; Rascol, A; Testut, MF | 1 |
| Peets, JM; Pomeranz, B; Power, C | 1 |
| Costa, E; Tang, J; Yang, HY | 1 |
| Sourek, K; Zichová, M | 1 |
| Livingston, A; Morris, B | 1 |
| Berntson, GG; Couri, D; McGivern, RF; Mousa, S | 1 |
| Ignatov, IuD; Kovalenko, VS; Titov, MI; Vasil'ev, IuN | 1 |
| Barbeau, A; Izumi, K; Munekata, E; Nakanishi, T; Yamamoto, H | 1 |
| Frederickson, RC; Wesche, DL | 1 |
| Boudouresque, F; Giraud, P; Guieu, R; Tardy-Gervet, MF | 1 |
| Mi, ZP; Qiao, JT; Zhang, RX | 1 |
| Ayala, J; Del Valle, M; Fuente, T; Hernández, LC; Iglesias, L; López, JM; Seijo, F | 1 |
| Carter, L; Schäfer, M; Stein, C | 1 |
| Portoghese, PS; Takemori, AE | 1 |
| Bach, FW; Yaksh, TL | 1 |
| Beitz, AJ; Mullet, MA; Williams, FG | 1 |
| Goldstein, BD; Zachariou, V | 1 |
| Ekblom, A; Ekman-Ordeberg, G; Irestedt, L; Nyberg, F; Olofsson, C; Ungerstedt, U; Wiklund, P | 1 |
| Kampine, JP; Mizoguchi, H; Narita, M; Tseng, LF | 1 |
| Deguchi, T; Imano, K; Kita, A; Nakamura, H; Seto, Y; Yakuo, I | 1 |
| Aebischer, P; Buchser, E; Décosterd, I; Gilliard, N; Saydoff, J; Zurn, AD | 1 |
| Ballof, J; Exton, MS; Exton, NG; Helfritz, F; Meyer, D; Nave, H; Pabst, R; Radulovic, J; Schmidt, RE; Stalp, M; Straub, RH; von Hörsten, S | 1 |
| Fan, XT; Kitamura, K; Oka, T; Taniguchi, T | 1 |
| Bytner, B; Lundeberg, T; Nylander, I; Rosén, A | 1 |
| Bès, JC; Duplan, H; Lazorthes, Y; Sagen, J; Sallerin, B; Sol, JC; Tafani, M; Tkaczuk, J | 1 |
| Eaton, MJ; Frydel, BR; Huang, J; Lopez, TL; McKillop, J; Nie, XT; Sagen, J | 1 |
| Huh, SO; Kim, YH; Song, DK; Suh, HW | 1 |
| Bette, M; Haake, M; Thon, A | 1 |
| Hung, K; Mizoguchi, H; Ohsawa, M; Tseng, LF; Wu, H | 1 |
| Bhardwaj, DK; Gupta, S; Gupta, YK; Pasha, S | 1 |
| Cabot, PJ; Carter, L; Schäfer, M; Stein, C | 1 |
| Fujimura, T; Hayashi, T; Kastin, AJ; Murayama, K; Narita, M; Orito, T; Sakurada, C; Sakurada, S; Sakurada, T; Suzuki, T; Tan-no, K; Tseng, LF; Yuhki, M; Zadina, JE | 1 |
| Ahmed, M; Bileviciute-Ljungar, I; Kreicbergs, A; Lundeberg, T; Nylander, I; Rydelius, G; Spetea, M; Svensson, S | 1 |
| Collins, KA; Suh, HH; Tseng, LF | 1 |
| Gavrilova, EM; Khegai, LA; Kim, BB; Yanovsky, OG; Zaitsev, SV; Zakharova, LA | 1 |
| Arai, Y; Ghoda, K; Kajita, T; Liu, XF; Matsumiya, T; Ohgiya, N; Oka, T; Taniguchi, T | 1 |
| Herz, A; Nikolarakis, K; Shippenberg, TS | 1 |
| Nakai, Y; Shioda, S; Wang, QP | 1 |
| Gramsch, C; Hassan, AH; Herz, A; Peter, K; Przewłocki, R; Stein, C | 1 |
| Rosenfeld, JP; Xia, LY | 1 |
| Bruchelt, G; Gupta, D; Handgretinger, R; Kaleva, N; Klingebiel, T; Niethammer, D; Treuner, J; Wollmann, H | 1 |
| Barontini, MB; Figuerola, ML; Leston, JA; Vindrola, O | 1 |
| Bourgoin, S; Cesselin, F; Clot, AM; Hamon, M; Le Bars, D | 3 |
| Himmelfarb, GN; Schumilowa, IJ | 1 |
| Inoki, R; Shibutani, T; Tsai, HY; Yonehara, N | 1 |
| Folkesson, R; Kisara, K; Sakurada, S; Sakurada, T; Takahashi, K; Terenius, L | 1 |
| Bourgoin, S; Cesselin, F; Fattaccini, CM; Gozlan, H; Hamon, M; Montastruc, JL; Rascol, A; Tran, MA | 1 |
| De Felipe, MC; Del Río, J; Molinero, MT | 1 |
| Inoki, R; Lin, JG; Tsai, HY | 1 |
| Wang, SK; Wang, YJ | 1 |
| Colpaert, FC; Członkowski, A; Herz, A; Millan, MH; Millan, MJ; Pilcher, CW | 1 |
| Candeletti, S; Ferri, S; Mantegazza, P; Panerai, AE; Sacerdote, P; Spampinato, S | 1 |
| Colpaert, FC; Członkowski, A; Herz, A; Höllt, V; Millan, MH; Millan, MJ; Pilcher, CW | 1 |
| Inoki, R; Kudo, T; Ohkubo, T; Shibata, M; Takahashi, H | 1 |
| Pezalla, PD; Stevens, CW; Yaksh, TL | 1 |
| Dyer, RS; Grimes, L; Harry, GJ; Hong, JS; Peterson, NJ; Rogers, BC; Tilson, HA | 1 |
| Pappas, GD; Sagen, J | 1 |
| Brown, MJ; Chierchia, S; Glazier, JJ; Maseri, A | 1 |
| Bianchi, M; Brini, A; Cocco, E; Marini, A; Panerai, AE; Sacerdote, P | 1 |
| Grossman, A | 1 |
| Artaud, F; Besson, JM; Bourgoin, S; Cesselin, F; Clot, AM; Gozlan, H; Hamon, M; Le Bars, D | 1 |
| Kameyama, T; Matsuno, K; Nabeshima, T | 1 |
| Biondi, M; Carilli, L; Fabbri, A; Fraioli, F; Moretti, C; Pancheri, P; Perrone, G; Santoro, A; Zichella, L | 1 |
| Kamei, H; Kameyama, T; Matsuno, K; Nabeshima, T; Noda, Y | 1 |
| Chang, JK; Huang, XH; Lu, WX; Mo, WY; Xu, SF; Xu, WM; Zhang, AZ; Zhou, KR | 1 |
| Sanchez, R; Vargas, L | 1 |
| Karczag, I; Székely, JI; Till, M; Tolna, J; Török, K | 1 |
| Inoki, R; Kudo, T; Nakao, T; Terasawa, M; Wei, EQ | 1 |
| Barchas, JD; Belluzzi, JD; Evans, CJ; Leslie, FM; Stein, L; Stevens, KE | 1 |
| Bourgoin, S; Cesselin, F; Dickenson, AH; Fournié-Zaluski, MC; Hamon, M; Le Bars, D; Roques, BP | 1 |
| Wang, XT; Wu, JL | 1 |
| Brandman, S; Currie, WJ; Jenkins, R; Vandenburg, MJ | 1 |
| Dodds, WN; Jayson, MI; Jones, CA; Rees, JM | 1 |
| Kubota, K; Matsuoka, Y; Satoh, S; Uruno, T | 1 |
| Faermark, IF; Shvarts, GIa | 1 |
| Bourgoin, S; Cesselin, F; Clot, MA; Hamon, M; Le Bars, D | 1 |
| Kurumaji, A; Ohi, K; Takahashi, K; Takashima, M | 1 |
| García-Antón, JM; Reig, F; Rodríguez, RE; Torres, JL; Valencia, G | 1 |
| Baker, M; de Ceballos, ML; Jenner, P; Marsden, CD; Rose, S | 1 |
| Rosenfeld, JP | 1 |
| Aimone, LD; Gebhart, GF; Randich, A | 1 |
| Bourgoin, S; Cesselin, F; Clot, AM; Hamon, M; Le Bars, D; Villanueva, L | 1 |
| Amann, R; Barthó, L; Lembeck, F; Saria, A; Szolcsányi, J | 1 |
| Han, JS; Shi, YS; Yu, LC | 1 |
| Fukushima, N; Ge, M; Kitao, T; Takagi, H; Ueda, H | 1 |
| Kasman, GS; Rosenfeld, JP | 1 |
| Hirota, N; Kuraishi, Y; Satoh, M; Takagi, H | 1 |
| Guan, XM; Li, LG; Liang, XC; Liu, XC; Wang, CY; Zeng, XY; Zhang, YW | 1 |
| Haigler, HJ; Hardy, SG | 1 |
| Apostol, CR; Davis, P; Forte, BL; Giri, AK; Hruby, VJ; Largent-Milnes, TM; Molnar, G; Olson, KM; Porreca, F; Rankin, D; Vanderah, TW; Wang, Y | 1 |
| Domon, Y; Fujimoto, T; Kawase, Y; Kubota, K; Noguchi, T; Shimada, K; Takano, R; Ueda, K; Umezaki, Y; Yabe, K; Yokoyama, M | 1 |
4 review(s) available for enkephalin, methionine and Pain
| Article | Year |
|---|---|
Gene therapy for pancreatitis pain.
Topics: Animals; Disease Models, Animal; Enkephalin, Methionine; Genetic Therapy; Genetic Vectors; Humans; Pain; Pain Management; Pancreatic Neoplasms; Pancreatitis, Chronic; Rats | 2009 |
Pain, nociception and spinal opioid receptors.
Topics: Animals; Dogs; Dynorphins; Endorphins; Enkephalin, Methionine; Guinea Pigs; Injections, Spinal; Mice; Pain; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Thermosensing; Touch | 1984 |
Possible involvement of taurine and GABA in morphine-like peptide actions.
Topics: Amino Acids; Analgesia; Animals; Enkephalin, Methionine; gamma-Aminobutyric Acid; Humans; Male; Motor Activity; Movement Disorders; Pain; Rats; Taurine | 1980 |
Functional response of multiple opioid systems to chronic arthritic pain in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Arthritis; Arthritis, Experimental; Benzomorphans; beta-Endorphin; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Morphine; Naloxone; Nociceptors; Pain; Pituitary Gland, Anterior; Protein Precursors; Pyrrolidines; Rats; Receptors, Opioid; Sensory Thresholds; Spinal Cord; Thalamus | 1986 |
3 trial(s) available for enkephalin, methionine and Pain
| Article | Year |
|---|---|
Expression of substance P, calcitonin gene-related peptide, β-endorphin and methionine-enkephalin in human dental pulp tissue after orthodontic intrusion: a pilot study.
Topics: Adolescent; beta-Endorphin; Bicuspid; Calcitonin Gene-Related Peptide; Child; Dental Pulp; Enkephalin, Methionine; Female; Humans; Male; Neurogenic Inflammation; Neurotransmitter Agents; Opioid Peptides; Pain; Pilot Projects; Substance P; Tooth Movement Techniques | 2014 |
Cerebrospinal fluid levels of opioid peptides in fibromyalgia and chronic low back pain.
Topics: Adult; Aged; Chronic Disease; Enkephalin, Methionine; Fatigue Syndrome, Chronic; Female; Fibromyalgia; Humans; Low Back Pain; Male; Middle Aged; Nociceptin; Opioid Peptides; Pain; Pain Measurement | 2004 |
Human chromaffin cell graft into the CSF for cancer pain management: a prospective phase II clinical study.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chromaffin Cells; Enkephalin, Methionine; Feasibility Studies; Female; Humans; Injections, Spinal; Male; Middle Aged; Morphine; Neoplasms; Pain; Pain Measurement; Pilot Projects; Prospective Studies; Severity of Illness Index; Transplantation, Homologous; Treatment Outcome | 2000 |
139 other study(ies) available for enkephalin, methionine and Pain
| Article | Year |
|---|---|
Na
Topics: Analgesics; Animals; Enkephalin, Methionine; Enkephalins; Ganglia, Spinal; Hyperalgesia; Mice; NAV1.7 Voltage-Gated Sodium Channel; Pain; Rats | 2023 |
Effects of botulinum toxin A on endometriosis‑associated pain and its related mechanism.
Topics: Adult; Animals; Botulinum Toxins, Type A; Cell Survival; Disease Models, Animal; Endometriosis; Enkephalin, Methionine; Female; Glucose; Humans; Mice; Mice, Inbred BALB C; Norepinephrine; Pain; PC12 Cells; Rats | 2020 |
The Chemokine CCL4 (MIP-1β) Evokes Antinociceptive Effects in Mice: a Role for CD4
Topics: Analgesics; Animals; CD4-Positive T-Lymphocytes; Chemokine CCL4; Enkephalin, Methionine; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Pain; Pain Measurement | 2019 |
Effects of Intracerebroventricular and Intra-Arcuate Nucleus Injection of Ghrelin on Pain Behavioral Responses and Met-Enkephalin and β-Endorphin Concentrations in the Periaqueductal Gray Area in Rats.
Topics: Animals; Arcuate Nucleus of Hypothalamus; beta-Endorphin; Enkephalin, Methionine; Ghrelin; Injections; Male; Pain; Pain Measurement; Periaqueductal Gray; Rats | 2019 |
Neonatal injury rapidly alters markers of pain and stress in rat pups.
Topics: Animals; Animals, Newborn; beta-Endorphin; Biomarkers; Brain Chemistry; Carrageenan; Corticosterone; Enkephalin, Methionine; Female; Inflammation; Pain; Pregnancy; Rats; Rats, Sprague-Dawley; Spinal Cord; Stress, Psychological | 2014 |
Preparation of a pipette tip-based molecularly imprinted solid-phase microextraction monolith by epitope approach and its application for determination of enkephalins in human cerebrospinal fluid.
Topics: Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Epitopes; Equipment Design; Humans; Limit of Detection; Microscopy, Electron, Scanning; Molecular Imprinting; Neoplasms; Pain; Polymers; Reproducibility of Results; Solid Phase Microextraction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Surface Properties | 2015 |
A prolonged nitric oxide-dependent, opioid-mediated antinociceptive effect of hyperbaric oxygen in mice.
Topics: Acetic Acid; Analgesia; Analysis of Variance; Animals; beta-Endorphin; Citrulline; Dynorphins; Enkephalin, Methionine; Enzyme Inhibitors; Hyperbaric Oxygenation; Injections, Intraperitoneal; Male; Mice; Microinjections; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Measurement; Thiourea | 2009 |
Mycobacteria attenuate nociceptive responses by formyl peptide receptor triggered opioid peptide release from neutrophils.
Topics: Analysis of Variance; Animals; Calcium; Cyclosporine; Enkephalin, Methionine; Freund's Adjuvant; Humans; Male; Monocytes; Mycobacterium; Narcotic Antagonists; Neurotransmitter Agents; Neutrophils; Nociceptors; Opioid Peptides; Pain; Phosphatidylinositol 3-Kinases; Rats; Rats, Wistar; Receptors, Formyl Peptide; Toll-Like Receptors | 2009 |
Intrathecal transplantation of autologous macrophages genetically modified to secrete proenkephalin ameliorated hyperalgesia and allodynia following peripheral nerve injury in rats.
Topics: Animals; Cells, Cultured; Enkephalin, Methionine; Enkephalins; Hot Temperature; Humans; Hyperalgesia; Injections, Spinal; Macrophages; Male; Pain; Pain Management; Pain Measurement; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Sciatic Neuropathy; Spinal Cord; Time Factors; Transfection; Transplantation, Autologous | 2009 |
Arginine vasopressin antinociception in the rat nucleus raphe magnus is involved in the endogenous opiate peptide and serotonin system.
Topics: Analgesics; Animals; Arginine Vasopressin; Choline; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Glutamic Acid; Indoles; Male; Opioid Peptides; Oxytocin; Pain; Pain Measurement; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin | 2009 |
Freezing of enkephalinergic functions by multiple noxious foci: a source of pain sensitization?
Topics: Animals; Enkephalin, Methionine; Enkephalins; Extremities; Male; Neural Inhibition; Pain; Protein Precursors; Rabbits; Rats; Rats, Sprague-Dawley; Spinal Cord; Trigeminal Caudal Nucleus; Trigeminal Nucleus, Spinal | 2009 |
[Bovine adrenal medulla 22 attenuates hyperalgesia in the early phase of complete Freund's adjuvant-induced inflammation in rats].
Topics: Animals; Calcitonin Gene-Related Peptide; Enkephalin, Methionine; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled | 2011 |
Oxytocin in the periaqueductal gray participates in pain modulation in the rat by influencing endogenous opiate peptides.
Topics: Animals; beta-Endorphin; Catheterization; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Microinjections; Naloxone; Narcotic Antagonists; Oxytocin; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Periaqueductal Gray; Radioimmunoassay; Rats; Rats, Sprague-Dawley | 2011 |
Endogenous endomorphin-2 contributes to spinal ĸ-opioid antinociception.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Dynorphins; Enkephalin, Methionine; Male; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 2012 |
Decreased plasma methionine-enkephalin levels in cluster headache patients.
Topics: Adult; Aminopeptidases; Blood Platelets; Case-Control Studies; Cluster Headache; Enkephalin, Methionine; Humans; Longitudinal Studies; Male; Middle Aged; Pain; Peptides; Time Factors | 2012 |
Supraspinal peroxynitrite modulates pain signaling by suppressing the endogenous opioid pathway.
Topics: Analysis of Variance; Animals; Carrageenan; CD11b Antigen; Cell Line, Transformed; Chromatography, Liquid; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Electrochemical Techniques; Enkephalin, Methionine; Glial Fibrillary Acidic Protein; Humans; Hyperalgesia; Injections, Spinal; Male; Medulla Oblongata; Metalloporphyrins; Microinjections; Neuroglia; Neurons; Opioid Peptides; Pain; Pain Measurement; Peroxynitrous Acid; Phosphopyruvate Hydratase; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrosine | 2012 |
Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue.
Topics: Alanine; Amino Acid Sequence; Animals; Antibodies; CD13 Antigens; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme Inhibitors; Flow Cytometry; Hindlimb; Inflammation; Leucine; Leukocytes; Male; Narcotic Antagonists; Neprilysin; Neurons; Opioid Peptides; Pain; Pain Threshold; Phosphinic Acids; Rats; Rats, Wistar; Receptors, Opioid; Thiorphan | 2012 |
Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Methionine; Formaldehyde; Glycopeptides; Kidney; Leucine; Male; Membrane Proteins; Molecular Sequence Data; Naltrexone; Neprilysin; Pain; Pain Measurement; Prostate; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Salivary Proteins and Peptides; Spinal Cord; Submandibular Gland; Substance P; Thiorphan; Wounds and Injuries | 2003 |
Different mechanisms of intrinsic pain inhibition in early and late inflammation.
Topics: Animals; Corticotropin-Releasing Hormone; Dynorphins; Edema; Endorphins; Enkephalin, Methionine; Freund's Adjuvant; Hindlimb; Inflammation; Injections, Subcutaneous; Leukocytes; Male; Naloxone; Pain; Pain Threshold; Rats; Rats, Wistar; Stress, Physiological; Time Factors | 2003 |
Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain--potential function of a novel receptor.
Topics: Acute Disease; Animals; Dose-Response Relationship, Drug; Enkephalin, Methionine; Injections, Spinal; Male; Pain; Pain Measurement; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 2004 |
The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat.
Topics: Animals; Arthritis, Experimental; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Freund's Adjuvant; Injections, Intradermal; Injections, Intraperitoneal; Male; Morphine; Mycobacterium; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant | 2004 |
Grafts of immortalized chromaffin cells bio-engineered to improve met-enkephalin release also reduce formalin-evoked c-fos expression in rat spinal cord.
Topics: Analysis of Variance; Animals; Cell Count; Cell Line, Transformed; Chromaffin Cells; Enkephalin, Methionine; Formaldehyde; Gene Expression Regulation; Genetic Engineering; Graft Survival; Humans; Immunohistochemistry; Male; Nerve Growth Factor; Pain; Phenylethanolamine N-Methyltransferase; Proto-Oncogene Proteins c-fos; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord; Transfection | 2004 |
Effects of intrathecal BAM22 on noxious stimulus-evoked c-fos expression in the rat spinal dorsal horn.
Topics: Animals; Cattle; Cell Count; Drug Interactions; Enkephalin, Methionine; Enkephalins; Formaldehyde; Gene Expression Regulation; Hot Temperature; Immunohistochemistry; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Pain; Pain Measurement; Physical Stimulation; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord | 2004 |
Analgesic activity of enkephalins following intracerebral administration in the rat.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Antagonism; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Male; Morphine; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Tail | 1977 |
A new electrochemical HPLC method for analysis of enkephalins and endomorphins.
Topics: Animals; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Male; Microdialysis; Oligopeptides; Pain; Perfusion; Posterior Horn Cells; Potassium Chloride; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 2006 |
Synthesis, conformational and pharmacological studies of glycosylated chimeric peptides of Met-enkephalin and FMRFa.
Topics: Animals; Blood-Brain Barrier; Dose-Response Relationship, Drug; Drug Design; Drug Interactions; Enkephalin, Methionine; FMRFamide; Glycopeptides; Glycosylation; Mass Spectrometry; Mice; Oligopeptides; Pain; Pain Measurement; Protein Conformation; Reaction Time; Time Factors | 2006 |
Genetically engineered human mesenchymal stem cells produce met-enkephalin at augmented higher levels in vitro.
Topics: Analgesics; Analgesics, Opioid; Cell Proliferation; Cells, Cultured; DNA; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Gene Fusion; Genetic Engineering; Genetic Vectors; Green Fluorescent Proteins; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Pain; Protein Precursors; Reverse Transcriptase Polymerase Chain Reaction; Transfection | 2006 |
Chimeric peptide of met-enkephalin and FMRFa: effect of chlorination on conformation and analgesia.
Topics: Analgesia; Analgesics, Opioid; Animals; Circular Dichroism; Enkephalin, Methionine; FMRFamide; Male; Mice; Octanols; Oligopeptides; Pain; Protein Structure, Secondary; Solubility; Water | 2006 |
Arginine vasopressin induces periaqueductal gray release of enkephalin and endorphin relating to pain modulation in the rat.
Topics: Acetylcholine; Animals; Arginine Vasopressin; beta-Endorphin; Choline; Dopamine; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Epinephrine; gamma-Aminobutyric Acid; Glutamic Acid; Male; Norepinephrine; Opioid Peptides; Oxytocin; Pain; Pain Threshold; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Serotonin | 2007 |
The involvement of spinal bovine adrenal medulla 22-like peptide, the proenkephalin derivative, in modulation of nociceptive processing.
Topics: Animals; Antibodies; Behavior, Animal; Disease Models, Animal; Enkephalin, Methionine; Freund's Adjuvant; Functional Laterality; Ganglia, Spinal; Gene Expression Regulation; Male; Neurons; Oncogene Proteins v-fos; Pain; Pain Measurement; Protein Precursors; Rats; Rhizotomy; Spinal Cord; Spinal Cord Injuries | 2007 |
The enhancing effects of peptidase inhibitors on the antinociceptive action of [Met5]enkephalin-Arg6-Phe7 in rats.
Topics: Analgesics; Animals; Captopril; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, Methionine; Glycopeptides; Injections, Intraventricular; Injections, Subcutaneous; Male; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Peptides; Protease Inhibitors; Rats; Rats, Wistar | 2007 |
Involvement of spinal Met-enkephalin in nicotine-induced antinociception in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Down-Regulation; Dynorphins; Enkephalin, Methionine; Enkephalins; Male; Mecamylamine; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nociceptors; Pain; Pain Measurement; Pain Threshold; Posterior Horn Cells; Pro-Opiomelanocortin; Protein Precursors; RNA, Messenger | 2008 |
Experimental pain and neuropeptides.
Topics: Animals; Enkephalin, Methionine; Male; Morphine; Pain; Rabbits; Rats; Rats, Inbred Strains; Reticular Formation; Spinal Cord; Substance P | 1984 |
Effect of neuroactive peptides on labeled 5-hydroxytryptamine release from rat spinal cord.
Topics: Animals; Baclofen; beta-Endorphin; Endorphins; Enkephalin, Methionine; Male; Naloxone; Neuropeptides; Neurotensin; Pain; Rats; Rats, Inbred Strains; Secretory Rate; Serotonin; Somatostatin; Spinal Cord; Substance P | 1984 |
[The role of multiple opioid receptors and their ligands in pain modulation].
Topics: Animals; Brain; Chronic Disease; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Pain; Receptors, Opioid; Spinal Cord | 1984 |
Lack of interaction between methionine enkephalin and D-phenylalanine on nociceptive and non-nociceptive responses of dorsal horn neurones of the cat.
Topics: Analgesia; Animals; Cats; Drug Interactions; Enkephalin, Methionine; Naloxone; Neurons; Pain; Phenylalanine; Receptors, Opioid; Reflex; Spinal Cord | 1984 |
On the etiopathogenesis of migraine: a possible link between the amines and endorphin hypotheses.
Topics: Adult; Clonidine; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Histamine; Humans; Male; Middle Aged; Migraine Disorders; Neurotransmitter Agents; Norepinephrine; Pain; Premedication; Prolactin; Sensory Thresholds; Serotonin; Substance Withdrawal Syndrome | 1982 |
Effect on perception and reaction to pain in opiate analgesia.
Topics: Analgesia; Analgesics, Opioid; Animals; Behavior, Animal; Enkephalin, Methionine; Female; Male; Mice; Morphine; Naloxone; Pain | 1983 |
Evidence for a role of the ventro-medial posterior hypothalamus in nociceptive processes in the rat.
Topics: Animals; beta-Endorphin; Dynorphins; Electroshock; Endorphins; Enkephalin, Methionine; Hypothalamus; Hypothalamus, Posterior; Male; Morphine; Naltrexone; Nociceptors; Pain; Protein Precursors; Rats; Rats, Inbred Strains; Stereotaxic Techniques | 1983 |
Acupuncture relief of chronic pain syndrome correlates with increased plasma met-enkephalin concentrations.
Topics: Acupuncture Therapy; beta-Endorphin; Chronic Disease; Endorphins; Enkephalin, Methionine; Female; Humans; Male; Mental Disorders; Pain; Pain Management; Syndrome | 1983 |
Substance P, morphine and methionine-enkephalin: effects on spontaneous and evoked neuronal firing in the nucleus reticularis gigantocellularis of the rat.
Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Medulla Oblongata; Morphine; Neurotransmitter Agents; Pain; Pressure; Rats; Substance P | 1980 |
Differential effects of D-Ala2 analogues of enkephalins on substance P-induced analgesia in rodents.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Pain; Rats; Rats, Inbred Strains; Substance P | 1982 |
Cyclic AMP, morphine, met-enkephalin and neuronal firing.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Action Potentials; Animals; Cyclic AMP; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Mesencephalon; Morphine; Neurons; Pain; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains | 1981 |
D-phenylalanine and other enkephalinase inhibitors as pharmacological agents: implications for some important therapeutic application.
Topics: Acupuncture Therapy; Animals; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Humans; Morphine; Morphine Dependence; Neprilysin; Nociceptors; Pain; Phenylalanine; Protease Inhibitors; Receptors, Opioid | 1982 |
Pain control by endogenous enkephalins is mediated by mu opioid receptors.
Topics: Amino Acids, Sulfur; Analgesia; Animals; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; Pain; Protease Inhibitors; Receptors, Opioid; Receptors, Opioid, mu; Thiorphan; Tiopronin | 1983 |
Afferent fibers mediate the increase of met-enkephalin elicited in rat spinal cord by localized pain.
Topics: Afferent Pathways; Animals; Enkephalin, Methionine; Freund's Adjuvant; Inflammation; Male; Nerve Fibers; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Synaptic Transmission | 1984 |
Localization of Met-enkephalin-like immunoreactivity within pain-related nuclei of cervical spinal cord, brainstem and midbrain in the cat.
Topics: Animals; Brain Stem; Cats; Enkephalin, Methionine; Histocytochemistry; Immunoenzyme Techniques; Mesencephalon; Neck; Olivary Nucleus; Pain; Periaqueductal Gray; Raphe Nuclei; Spinal Cord; Trigeminal Nucleus, Spinal | 1983 |
Met-enkephalin-Arg6-Phe7-like immunoreactive substances mediate electroacupuncture analgesia in the periaqueductal gray of the rabbit.
Topics: Acupuncture Therapy; Animals; Brain Mapping; Captopril; Combined Modality Therapy; Electric Stimulation Therapy; Enkephalin, Methionine; Male; Naloxone; Pain; Pain Management; Periaqueductal Gray; Rabbits | 1984 |
Normal CSF levels of met-enkephalin-like material in a case of naloxone-reversible congenital insensitivity to pain.
Topics: Adult; Enkephalin, Methionine; Epilepsy; Female; Humans; Naloxone; Nociceptors; Pain; Reference Values; Skin | 1984 |
Long latency spinal cord dorsum potential; suppression by intrathecal morphine and enkephalin analog.
Topics: Analgesics; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Enkephalin, Methionine; Evoked Potentials; Injections, Spinal; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Spinal Cord | 1984 |
Inhibition of spontaneous and opiate-modified nociception by an endogenous neuropeptide with Phe-Met-Arg-Phe-NH2-like immunoreactivity.
Topics: Animals; Drug Tolerance; Enkephalin, Methionine; FMRFamide; Male; Morphine; Oligopeptides; Pain; Rats; Spinal Cord | 1984 |
[Endogenous opiate peptides and quantification of surgical results in pain].
Topics: Electrocoagulation; Enkephalin, Methionine; Humans; Pain; Spinal Cord | 1984 |
Effects of nitrous oxide exposure on Met-enkephalin levels in discrete areas of rat brain.
Topics: Animals; Brain Chemistry; Endorphins; Enkephalin, Methionine; Male; Nitrous Oxide; Pain; Radioimmunoassay; Rats; Rats, Inbred Strains; Tissue Distribution | 1984 |
Prolonged intermittent footshock stress decreases Met and Leu enkephalin levels in brain with concomitant decreases in pain threshold.
Topics: Animals; Body Temperature; Brain; Electroshock; Enkephalin, Leucine; Enkephalin, Methionine; Foot; Latency Period, Psychological; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Stress, Physiological | 1983 |
[Effect of met- and leu-enkephalins and their synthetic analog on stimulation and acupunture analgesia].
Topics: Acupuncture Therapy; Analgesia; Animals; Brain Stem; Electric Stimulation Therapy; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Pain; Pain Management; Rats | 1981 |
The role of the pituitary in the diurnal variation in tolerance to painful stimuli and brain enkephalin levels.
Topics: Animals; Brain; Circadian Rhythm; Endorphins; Enkephalin, Methionine; Enkephalins; Humans; Hypophysectomy; Male; Mice; Naloxone; Pain; Pituitary Gland; Prolactin; Rats; Stress, Psychological | 1981 |
Morphine and methionine-enkephalin: different effects on spontaneous and evoked neuronal firing in the mesencephalic reticular formation of the rat.
Topics: Action Potentials; Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Iontophoresis; Male; Mesencephalon; Morphine; Neurons; Pain; Rats; Reticular Formation | 1980 |
[Met-enkephalin and substance P. Comparison of CSF levels in patients with chronic pain based on a sampling procedure].
Topics: Adult; Aged; Chronic Disease; Enkephalin, Methionine; Female; Humans; Male; Middle Aged; Pain; Sampling Studies; Spinal Puncture; Substance P; Ventriculoperitoneal Shunt | 1993 |
Changes of spinal substance P, calcitonin gene-related peptide, somatostatin, Met-enkephalin and neurotensin in rats in response to formalin-induced pain.
Topics: Animals; Calcitonin Gene-Related Peptide; Enkephalin, Methionine; Female; Formaldehyde; Image Processing, Computer-Assisted; Male; Microscopy, Electron; Neuropeptides; Neurotensin; Pain; Rats; Rats, Sprague-Dawley; Somatostatin; Spinal Cord; Substance P | 1994 |
Changes in hypothalamic met-enkephalin levels of rats induced by painful stimulation and morphine treatment.
Topics: Animals; Enkephalin, Methionine; Formaldehyde; Hypothalamus; Male; Morphine; Naloxone; Pain; Rats; Rats, Wistar; Stimulation, Chemical | 1993 |
Interleukin 1 beta and corticotropin-releasing factor inhibit pain by releasing opioids from immune cells in inflamed tissue.
Topics: Analysis of Variance; Animals; Antibodies; beta-Endorphin; Corticotropin-Releasing Hormone; Cyclosporine; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Inflammation; Injections; Interleukin-1; Male; Naloxone; Pain; Rats; Rats, Wistar; Recombinant Proteins; Regression Analysis; Somatostatin | 1994 |
Enkephalin antinociception in mice is mediated by delta 1- and delta 2-opioid receptors in the brain and spinal cord, respectively.
Topics: Animals; Benzylidene Compounds; beta-Endorphin; Brain; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Injections, Spinal; Male; Mice; Naltrexone; Pain; Receptors, Opioid, delta; Spinal Cord | 1993 |
Release into ventriculo-cisternal perfusate of beta-endorphin- and Met-enkephalin-immunoreactivity: effects of electrical stimulation in the arcuate nucleus and periaqueductal gray of the rat.
Topics: Animals; Arcuate Nucleus of Hypothalamus; beta-Endorphin; Cerebral Ventricles; Cisterna Magna; Electric Stimulation; Enkephalin, Methionine; Immunohistochemistry; Male; Pain; Pain Measurement; Perfusion; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reflex | 1995 |
Basal release of Met-enkephalin and neurotensin in the ventrolateral periaqueductal gray matter of the rat: a microdialysis study of antinociceptive circuits.
Topics: Animals; Basal Metabolism; Bicuculline; Enkephalin, Methionine; Feedback; GABA Antagonists; Male; Microdialysis; Morphine; Neural Pathways; Neurotensin; Pain; Periaqueductal Gray; Rats; Rats, Sprague-Dawley | 1995 |
Delta-Opioid receptor modulation of the release of substance P-like immunoreactivity in the dorsal horn of the rat following mechanical or thermal noxious stimulation.
Topics: Animals; Decerebrate State; Enkephalin, Methionine; Functional Laterality; Hindlimb; Hot Temperature; Male; Naltrexone; Narcotic Antagonists; Pain; Physical Stimulation; Rats; Rats, Wistar; Receptors, Opioid, delta; Spinal Cord; Substance P; Time Factors | 1996 |
Increased cerebrospinal fluid concentration of aspartate but decreased concentration of nitric oxide breakdown products in women experiencing visceral pain during active labour.
Topics: Adult; Aged; Analgesia; Aspartic Acid; Cesarean Section; Delivery, Obstetric; Enkephalin, Methionine; Female; Humans; Labor, Obstetric; Metalloendopeptidases; Middle Aged; Nitric Oxide; Pain; Postmenopause; Pregnancy; Reference Values; Substance P | 1997 |
[Met5]enkephalin and delta2-opioid receptors in the spinal cord are involved in the cold water swimming-induced antinociception in the mouse.
Topics: Animals; beta-Endorphin; Cold Temperature; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1997 |
Antinociceptive and antidepressant-like profiles of BL-2401, a novel enkephalinase inhibitor, in mice and rats.
Topics: Administration, Oral; Analgesics; Analgesics, Opioid; Animals; Antidepressive Agents; Benzoates; Benzoquinones; Corpus Striatum; Curcumin; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, Methionine; Female; Hyperalgesia; Male; Mice; Naloxone; Narcotic Antagonists; Narcotics; Neprilysin; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sulfhydryl Compounds; Swimming | 1997 |
Intrathecal implants of bovine chromaffin cells alleviate mechanical allodynia in a rat model of neuropathic pain.
Topics: Animals; Behavior, Animal; Catecholamines; Cattle; Cell Transplantation; Chromaffin Cells; Enkephalin, Methionine; Male; Neuropeptides; Pain; Pain Management; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord; Transplantation, Heterologous | 1998 |
Centrally applied NPY mimics immunoactivation induced by non-analgesic doses of met-enkephalin.
Topics: Adjuvants, Immunologic; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Methionine; Injections, Intraventricular; Male; Neuropeptide Y; Pain; Rats; Rats, Inbred Lew | 1998 |
Effects of peptidase inhibitors on the enkephalin-induced anti-nociception in rats.
Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Captopril; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enkephalin, Methionine; Glycopeptides; Injections, Intraventricular; Injections, Subcutaneous; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Peptides; Protease Inhibitors; Rats; Rats, Wistar | 1998 |
Central changes in nociceptin dynorphin B and Met-enkephalin-Arg-Phe in different models of nociception.
Topics: Animals; Brain; Dynorphins; Efferent Pathways; Endorphins; Enkephalin, Methionine; Inflammation; Male; Nerve Crush; Nociceptin; Nociceptors; Opioid Peptides; Pain; Rats; Rats, Sprague-Dawley | 2000 |
Generation and initial characterization of conditionally immortalized chromaffin cells.
Topics: Adrenal Glands; Animals; Catecholamines; Cattle; Cell Differentiation; Cell Line, Transformed; Chromaffin Cells; Chromatography, High Pressure Liquid; Colforsin; Dexamethasone; Dopamine beta-Hydroxylase; Enkephalin, Methionine; Female; Hot Temperature; Humans; Immunohistochemistry; Pain; Pain Management; Peripheral Nerve Injuries; Phenylethanolamine N-Methyltransferase; Rats; Spinal Cord Injuries; Tyrosine 3-Monooxygenase | 2000 |
Involvement of dynorphin in immobilization stress-induced antinociception in the mouse.
Topics: Animals; beta-Endorphin; Cerebral Ventricles; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Reaction Time; Restraint, Physical; Stress, Psychological | 2000 |
Absence of spinal response to extracorporeal shock waves on the endogenous opioid systems in the rat.
Topics: Animals; Chi-Square Distribution; Dynorphins; Enkephalin, Methionine; Immunohistochemistry; Lithotripsy; Pain; Rats; Rats, Wistar; Spinal Cord | 2001 |
Antisera against endogenous opioids increase the nocifensive response to formalin: demonstration of inhibitory beta-endorphinergic control.
Topics: Animals; beta-Endorphin; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Formaldehyde; Immune Sera; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Nociceptors; Opioid Peptides; Pain | 2001 |
Effects of intracerebroventricularly administered chimeric peptide of metenkephalin and FMRFa--[D-Ala2]YFa-on antinociception and its modulation in mice.
Topics: Analgesics, Opioid; Animals; Brain; Drug Interactions; Enkephalin, Methionine; FMRFamide; Injections, Intraventricular; Mice; Mice, Inbred Strains; Morphine; Naloxone; Narcotic Antagonists; Neurons; Nociceptors; Oligopeptides; Pain; Pain Measurement; Recombinant Fusion Proteins | 2001 |
Methionine-enkephalin-and Dynorphin A-release from immune cells and control of inflammatory pain.
Topics: Animals; Antibodies; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Methionine; Humans; Inflammation; Interleukin-2; Lymphocytes; Male; Pain; Rats; Rats, Wistar | 2001 |
Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse.
Topics: Analgesics; Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Time Factors | 2001 |
Alteration in endogenous opioid systems due to chronic inflammatory pain conditions.
Topics: Animals; Brain; Chronic Disease; Disease Models, Animal; Dynorphins; Endorphins; Enkephalin, Methionine; Female; Inflammation; Opioid Peptides; Pain; Pain Measurement; Rats; Rats, Inbred Lew; Receptors, Opioid; Spinal Cord | 2002 |
Intrathecal cholecystokinin octapeptide attenuates the antinociception and release of immunoreactive Met-enkephalin induced by intraventricular beta-endorphin in the rat.
Topics: Animals; beta-Endorphin; Depression, Chemical; Enkephalin, Methionine; Injections, Intraventricular; Injections, Spinal; Narcotic Antagonists; Pain; Proglumide; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Reflex; Secretory Rate; Sincalide; Spinal Cord; Tail | 1992 |
Involvement of opioid receptors in Met-enkephalin modulation of blast-transformation of mouse splenocytes.
Topics: Animals; Binding, Competitive; Concanavalin A; Diprenorphine; Enkephalin, Methionine; Enterotoxins; Female; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Naloxone; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sensory Thresholds; Spleen | 1992 |
Effects of the subcutaneous administration of enkephalins on tail-flick response and righting reflex of developing rats.
Topics: Aging; Animals; Anti-Bacterial Agents; Captopril; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Female; Glycopeptides; Injections, Subcutaneous; Male; Oligopeptides; Pain; Peptides; Posture; Protease Inhibitors; Rats; Rats, Wistar; Reflex | 1992 |
Prolonged inflammatory pain modifies corticotropin-releasing factor-induced opioid peptide release in the hypothalamus.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; beta-Endorphin; Corticotropin-Releasing Hormone; Dynorphins; Electroshock; Endorphins; Enkephalin, Methionine; Hypothalamus; In Vitro Techniques; Inflammation; Male; Pain; Potassium Chloride; Radioimmunoassay; Rats; Rats, Inbred Strains; Restraint, Physical; Stress, Psychological | 1991 |
Enkephalinergic synaptic axon terminals on serotoninergic neurons in the dorsal raphe nucleus of the rat: an electron microscopic study by the double immunostaining method.
Topics: Animals; Axons; Enkephalin, Methionine; Male; Microscopy, Immunoelectron; Nerve Endings; Pain; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin; Synapses | 1991 |
Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation.
Topics: Animals; Antibodies, Monoclonal; beta-Endorphin; Dynorphins; Enkephalin, Methionine; Freund's Adjuvant; Immunoenzyme Techniques; Inflammation; Male; Neurons, Afferent; Pain; Physical Exertion; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Opioid; Reference Values; Skin | 1990 |
Effects of single nanoinjections of Met-enkephalin in the minimally anesthetized rat brainstem on trigeminal nuclear neurons: differential effects on spontaneous versus evoked activity and noci-evoked versus innocuously-evoked responses.
Topics: Anesthesia; Animals; Behavior, Animal; Brain Stem; Electrophysiology; Enkephalin, Methionine; Evoked Potentials; Male; Microelectrodes; Microinjections; Neurons; Pain; Periaqueductal Gray; Raphe Nuclei; Rats; Rats, Inbred Strains; Reticular Formation; Trigeminal Nuclei | 1991 |
Opioid peptides as possible cause of pain reduction in neuroblastoma after admission of 131I-meta-iodobenzylguanidine.
Topics: 3-Iodobenzylguanidine; Antineoplastic Agents; beta-Endorphin; Child; Child, Preschool; Enkephalin, Methionine; Humans; Iodine Radioisotopes; Iodobenzenes; Neuroblastoma; Pain; Time Factors | 1991 |
Increase in plasma methionine-enkephalin levels during the pain attack in episodic cluster headache.
Topics: Adult; Cluster Headache; Enkephalin, Methionine; Epinephrine; Female; Humans; Male; Middle Aged; Norepinephrine; Pain; Time Factors | 1990 |
Subcutaneous formalin induces a segmental release of Met-enkephalin-like material from the rat spinal cord.
Topics: Animals; Enkephalin, Methionine; Formaldehyde; Injections, Subcutaneous; Lumbosacral Region; Male; Neck; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Stimulation, Chemical | 1990 |
[The role of humoral factors in the mechanism of the analgesic effect of electroacupuncture].
Topics: Animals; Dinoprost; Dogs; Electroacupuncture; Enkephalin, Leucine; Enkephalin, Methionine; Histamine; Pain; Serotonin | 1990 |
Effects of opioids and opioid peptide on the release of substance P-like material induced by tooth pulp stimulation in the trigeminal nucleus caudalis of the rabbit.
Topics: Animals; Dental Pulp; Electric Stimulation; Enkephalin, Methionine; Male; Morphine; Naloxone; Pain; Rabbits; Substance P; Trigeminal Nuclei | 1986 |
Enkephalins interact with substance P-induced aversive behaviour in mice.
Topics: Animals; beta-Endorphin; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Methionine; Injections, Spinal; Mice; Nociceptors; Pain; Reaction Time; Substance P | 1988 |
Chronic chlorimipramine does not reverse the reduction of cerebrospinal fluid Met-enkephalin-like immunoreactivity in chronic-pain patients.
Topics: Adult; Aged; Chronic Disease; Clomipramine; Enkephalin, Methionine; Enkephalins; Female; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Pain; Radioimmunoassay; Serotonin | 1987 |
Long-lasting neurochemical and functional changes in rats induced by neonatal administration of substance P antiserum.
Topics: Animals; Animals, Newborn; Antibodies; Blood Pressure; Enkephalin, Methionine; Hydroxyindoleacetic Acid; Male; Pain; Periaqueductal Gray; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1989 |
Further evidence for possible analgesic mechanism of electroacupuncture: effects on neuropeptides and serotonergic neurons in rat spinal cord.
Topics: Acupuncture Therapy; Analgesia, Epidural; Animals; Baclofen; Electric Stimulation; Enkephalin, Methionine; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Serotonin; Spinal Cord; Substance P | 1989 |
Effects of phentolamine and propranolol on the changes of pain threshold and contents of MEK and LEK in rat brain after EA.
Topics: Animals; Brain; Electroacupuncture; Enkephalin, Leucine; Enkephalin, Methionine; Male; Pain; Phentolamine; Propranolol; Rats; Sensory Thresholds | 1989 |
Segmental release of Met-enkephalin-like material from the spinal cord of rats, elicited by noxious thermal stimuli.
Topics: Animals; Enkephalin, Methionine; Hot Temperature; Male; Pain; Rats; Rats, Inbred Strains; Spinal Cord | 1989 |
Spinal cord dynorphin may modulate nociception via a kappa-opioid receptor in chronic arthritic rats.
Topics: Animals; Arthritis; Chronic Disease; Conditioning, Classical; Dynorphins; Enkephalin, Methionine; Mycobacterium Infections; Naloxone; Nociceptors; Pain; Radioimmunoassay; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord | 1985 |
Naloxone-reversible and non-reversible shock-induced analgesia during development.
Topics: Analgesia; Animals; beta-Endorphin; Central Nervous System; Dynorphins; Electroshock; Endorphins; Enkephalin, Methionine; Male; Naloxone; Pain; Rats; Rats, Inbred Strains | 1985 |
[Peripheral analgesic actions of opioid peptides and morphine analogues].
Topics: Analgesics, Opioid; Animals; Cyclazocine; Dynorphins; Enkephalin, Methionine; Ethylketocyclazocine; Levallorphan; Lidocaine; Male; Mice; Morphine; Naloxone; Pain; Peptide Fragments | 1986 |
Spinal antinociceptive action of three representative opioid peptides in frogs.
Topics: Analgesics; Animals; beta-Endorphin; Dynorphins; Endorphins; Enkephalin, Methionine; Pain; Rana pipiens; Sensory Thresholds; Spinal Cord | 1987 |
Time-dependent neurobiological effects of colchicine administered directly into the hippocampus of rats.
Topics: Acoustic Stimulation; Animals; Avoidance Learning; Behavior, Animal; Colchicine; Dynorphins; Enkephalin, Methionine; Hippocampus; Male; Motor Activity; Pain; Peptide Fragments; Rats; Rats, Inbred F344; Reaction Time; Reflex, Startle; Time Factors | 1987 |
Pharmacologic consequences of the vascular permeability of chromaffin cell transplants in CNS pain modulatory regions.
Topics: Adrenal Medulla; Analgesics; Animals; Blood-Brain Barrier; Capillary Permeability; Central Nervous System; Chromaffin System; Enkephalin, Methionine; Ganglionic Blockers; Ganglionic Stimulants; Male; Narcotic Antagonists; Pain; Rats; Rats, Inbred Strains | 1988 |
Importance of generalized defective perception of painful stimuli as a cause of silent myocardial ischemia in chronic stable angina pectoris.
Topics: Angina Pectoris; beta-Endorphin; Chronic Disease; Coronary Disease; Endorphins; Enkephalin, Methionine; Humans; Male; Middle Aged; Norepinephrine; Pain; Perception; Sensory Thresholds | 1986 |
Effect of chronic morphine on plasma and brain beta endorphin and methionine enkephalin in pregnant rats and in their fetuses or newborn.
Topics: Animals; Animals, Newborn; beta-Endorphin; Brain; Enkephalin, Methionine; Female; Fetus; Hypothalamus; Morphine; Pain; Pituitary Gland; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains | 1988 |
Endorphins: "opiates for the masses".
Topics: Acupuncture Therapy; Adrenocorticotropic Hormone; beta-Endorphin; Catecholamines; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalin, Methionine; Growth Hormone; Humans; Luteinizing Hormone; Naloxone; Pain; Physical Exertion; Receptors, Opioid; Sensory Thresholds; Stress, Physiological | 1985 |
Spontaneous and evoked release of methionine-enkephalin-like material from the rat spinal cord in vivo.
Topics: Animals; Chromatography, Gel; Chromatography, High Pressure Liquid; Enkephalin, Methionine; Male; Pain; Potassium; Rats; Rats, Inbred Strains; Spinal Cord; Synaptic Transmission | 1985 |
Involvement of different opioid receptor subtypes in electric shock-induced analgesia and motor suppression in the rat.
Topics: Animals; Cyclazocine; Electroshock; Enkephalin, Methionine; Ethylketocyclazocine; Male; Motor Activity; Naloxone; Pain; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Opioid; Time Factors | 1985 |
ACTH, beta-endorphin and met-enkephalin: peripheral modifications during the stress of human labor.
Topics: Adrenocorticotropic Hormone; Adult; Anxiety; beta-Endorphin; beta-Lipotropin; Endorphins; Enkephalin, Methionine; Female; Humans; Labor, Obstetric; Pain; Pregnancy; Stress, Physiological | 1985 |
Electric footshock-induced changes in behavior and opioid receptor function.
Topics: Analgesia; Animals; Behavior, Animal; Binding, Competitive; Electroshock; Enkephalin, Methionine; Kinetics; Male; Motor Activity; Naloxone; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Sensory Thresholds; Synaptic Membranes | 1985 |
[Analgesic effect of metorphamide on skin pain and visceral pain].
Topics: Analgesics; Animals; Enkephalin, Methionine; Female; Male; Mice; Morphine; Naloxone; Pain; Rabbits; Receptors, Opioid; Receptors, Opioid, mu; Sensory Thresholds | 1986 |
Inhibition of stress-induced hyperglycemia by tail pinching or intraventricular enkephalin administration in the rat.
Topics: Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Methionine; Hyperglycemia; Injections, Intraventricular; Insulin; Male; Naloxone; Pain; Rats; Rats, Inbred Strains; Restraint, Physical; Tail | 1988 |
Effects of D-Met2, Pro5-enkephalinamide on pain tolerance and some cognitive functions in man.
Topics: Adult; Attention; Codeine; Cognition; Enkephalin, Methionine; Humans; Male; Memory; Memory, Short-Term; Middle Aged; Pain; Sensory Thresholds | 1986 |
Influence of Y-20003, an analgesic agent, on the endogenous opioid peptide system in rats.
Topics: Adrenal Medulla; Aminoquinolines; Animals; Arthritis, Experimental; Endorphins; Enkephalin, Methionine; Kinetics; Male; Pain; Rats; Rats, Inbred Lew | 1986 |
Intraventricular administration of BAM-18: antinociceptive and locomotor activity in the rat.
Topics: Analgesia; Animals; Cerebral Ventricles; Enkephalin, Methionine; Male; Motor Activity; Pain; Protein Precursors; Rats; Rats, Inbred Strains | 1986 |
Increase in met-enkephalin level and antinociceptive effects induced by kelatorphan in the rat spinal cord.
Topics: Analgesics; Animals; Dipeptides; Enkephalin, Methionine; In Vitro Techniques; Leucine; Neurons; Pain; Rats; Spinal Cord; Thiorphan; Tiopronin | 1986 |
[Influence of electroacupuncture and antagonism of electroacupuncture analgesia by naloxone on enkephalin-like immunoreactivity in guinea pig's adrenal and spinal cord].
Topics: Acupuncture Therapy; Adrenal Glands; Analgesia; Animals; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; Immunohistochemistry; Male; Naloxone; Pain; Sensory Thresholds; Spinal Cord | 1988 |
The effect of non-steroidal anti-inflammatory therapy on plasma neuropeptide concentrations in patients with osteoarthritis.
Topics: Aged; Anti-Inflammatory Agents; beta-Endorphin; Delayed-Action Preparations; Endorphins; Enkephalin, Methionine; Female; Humans; Indomethacin; Male; Middle Aged; Osteoarthritis; Pain | 1985 |
Changes in plasma opioid concentrations after physiotherapeutic exercises for arthritic patients.
Topics: Adult; Aged; Arthritis; beta-Endorphin; Chronic Disease; Endorphins; Enkephalin, Methionine; Exercise Therapy; Female; Humans; Male; Middle Aged; Pain; Pain Management | 1985 |
2S,3R 3-amino-2-hydroxy-4-phenylbutanoic acid derivatives, enkephalinase inhibitors, augment met5-enkephalin-induced antinociception.
Topics: Analgesics; Animals; Drug Synergism; Enkephalin, Methionine; Leucine; Male; Metalloendopeptidases; Mice; Mice, Inbred Strains; Neprilysin; Pain; Phenylbutyrates; Sensory Thresholds | 1988 |
[Influence of captopril on the in vitro and in vivo effects of leu- and met-enkephalins].
Topics: Animals; Captopril; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Enkephalin, Leucine; Enkephalin, Methionine; Female; Guinea Pigs; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Pain; Time Factors | 1987 |
Spontaneous and evoked release of met-enkephalin-like material from the spinal cord of arthritic rats in vivo.
Topics: Animals; Arthritis; Arthritis, Experimental; Enkephalin, Methionine; Male; Pain; Rats; Rats, Inbred Strains; Spinal Cord | 1988 |
Circadian fluctuations in pain responsiveness and brain Met-enkephalin-like immunoreactivity in the rat.
Topics: Animals; Brain; Circadian Rhythm; Enkephalin, Methionine; Male; Pain; Rats; Rats, Inbred Strains; Tissue Distribution | 1988 |
[D-Met2,Pro5] enkephalin [N1.5-beta-D-glucopyranosyl] amide: a glycosylpeptide with high antinociceptive activity.
Topics: Analgesics; Animals; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Indicators and Reagents; Male; Mice; Mice, Inbred ICR; Morphine; Muscle Contraction; Muscle, Smooth; Pain; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1988 |
Do enkephalins in basal ganglia mediate a physiological motor rest mechanism?
Topics: Animals; Basal Ganglia; Biogenic Monoamines; Burns; Dopamine; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Locomotion; Male; Pain; Rats; Rats, Inbred Strains; Rest; Sensory Thresholds; Time Factors | 1986 |
The response of individual nucleus raphe magnus neurons to microinjections of met-enkephalin at midbrain and at bulbar loci: evidence for midbrain-bulbar convergence on individual raphe neurons.
Topics: Action Potentials; Animals; Brain Mapping; Enkephalin, Methionine; Male; Medulla Oblongata; Neural Pathways; Pain; Periaqueductal Gray; Raphe Nuclei; Rats; Rats, Inbred Strains | 1987 |
Medullary substrates of descending spinal inhibition activated by intravenous administration of [D-Ala2]methionine enkephalinamide in the rat.
Topics: Anesthetics, Local; Animals; Blood Pressure; Efferent Pathways; Enkephalin, Methionine; Heart Rate; Male; Medulla Oblongata; Neural Inhibition; Pain; Raphe Nuclei; Rats; Rats, Inbred Strains; Reticular Formation; Spinal Cord; Vagus Nerve | 1987 |
Involvement of the dorsolateral funiculi in the spinal release of Met-enkephalin-like material triggered by heterosegmental noxious mechanical stimuli.
Topics: Animals; Enkephalin, Methionine; Pain; Physical Stimulation; Radioimmunoassay; Rats; Spinal Cord | 1987 |
Peripheral effects of opioid drugs on capsaicin-sensitive neurones of the guinea-pig bronchus and rabbit ear.
Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Bronchi; Capsaicin; Ear, External; Enkephalin, Methionine; Female; Fentanyl; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Narcotics; Neurons; Pain; Rabbits | 1987 |
[Analgesia induced by morphine administered to the nucleus accumbens was blocked by naloxone or [Met5] enkephalin antiserum injected into the periaqueductal gray of the rabbit].
Topics: Analgesia; Animals; Efferent Pathways; Enkephalin, Methionine; Immune Sera; Male; Microinjections; Morphine; Naloxone; Nucleus Accumbens; Pain; Periaqueductal Gray; Rabbits; Sensory Thresholds; Septal Nuclei | 1987 |
Low doses of naloxone produce analgesia in the mouse brain by blocking presynaptic autoinhibition of enkephalin release.
Topics: Analgesia; Animals; Brain Chemistry; Dose-Response Relationship, Drug; Enkephalin, Methionine; Male; Mice; Naloxone; Neural Inhibition; Pain; Rats; Rats, Inbred Strains; Time Factors | 1986 |
Opiate microinjections into midbrain do not affect the aversiveness of caudal trigeminal stimulation but produce somatotopically organized peripheral hypoalgesia.
Topics: Animals; Enkephalin, Methionine; Hot Temperature; Male; Morphine; Pain; Periaqueductal Gray; Rats; Reticular Formation; Sensory Thresholds; Trigeminal Nucleus, Spinal | 1986 |
Noxious mechanical stimuli increase the release of Met-enkephalin-like material heterosegmentally in the rat spinal cord.
Topics: Animals; Enkephalin, Methionine; Neural Inhibition; Pain; Potassium; Radioimmunoassay; Rats; Spinal Cord; Trigeminal Caudal Nucleus; Trigeminal Nucleus, Spinal | 1987 |
Antinociceptive effects of intrathecal opioids, noradrenaline and serotonin in rats: mechanical and thermal algesic tests.
Topics: Analgesics; Animals; Enkephalin, Methionine; Injections, Spinal; Male; Morphine; Norepinephrine; Pain; Rats; Rats, Inbred Strains; Serotonin | 1985 |
[Investigations on the relationship between methionine-enkephalin (Met-Enk) and acetylcholine (ACh) in brain of rats, with their influence on the effect of electroacupuncture analgesia].
Topics: Acetylcholine; Acupuncture Therapy; Animals; Brain Chemistry; Electric Stimulation Therapy; Enkephalin, Methionine; Female; Male; Pain; Radioimmunoassay; Rats; Sensory Thresholds; Transcutaneous Electric Nerve Stimulation | 1985 |
Prefrontal influences upon the midbrain: a possible route for pain modulation.
Topics: Acetylcholine; Analgesia; Animals; Brain Mapping; Enkephalin, Methionine; Frontal Lobe; Neural Pathways; Norepinephrine; Pain; Rats; Rats, Inbred Strains; Reaction Time | 1985 |
Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain.
Topics: Amino Acid Sequence; Analgesics; Animals; HEK293 Cells; Humans; Male; Mice; Neurokinin-1 Receptor Antagonists; Pain; Peptides; Rats; Receptors, Neurokinin-1; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship | 2015 |
A novel [5.2.1]bicyclic amine is a potent analgesic without µ opioid activity.
Topics: Acetic Acid; Amines; Analgesics; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Mice; Mice, Inbred Strains; Molecular Structure; Pain; Pain Measurement; Structure-Activity Relationship | 2021 |