E3 ubiquitin-protein ligase TRIM33

An E3 ubiquitin-protein ligase TRIM33 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UPN9]

Synonyms

EC 2.3.2.27;
Ectodermin homolog;
RET-fused gene 7 protein;
Protein Rfg7;
RING-type E3 ubiquitin transferase TRIM33;
Transcription intermediary factor 1-gamma;
TIF1-gamma;
Tripartite motif-containing protein 33

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (7)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
vanillin	Homo sapiens (human)	IC50	0.3256	1	0
salicylaldehyde	Homo sapiens (human)	IC50	0.2994	1	0
cyclopentanone	Homo sapiens (human)	IC50	0.2335	1	0
cyclooctanone	Homo sapiens (human)	IC50	0.2498	1	0
2-hydroxy-4-methoxybenzaldehyde	Homo sapiens (human)	IC50	0.3006	1	0
i-bet726	Homo sapiens (human)	IC50	12.9244	2	2
dBET6	Homo sapiens (human)	IC50	4.6900	1	0

Enables

This protein enables 6 target(s):

Target	Category	Definition
DNA binding	molecular function	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
ubiquitin-protein transferase activity	molecular function	Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. [GOC:BioGRID, GOC:jh2, PMID:9635407]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
co-SMAD binding	molecular function	Binding to a common mediator SMAD signaling protein. [GOC:BHF, GOC:vk, PMID:19114992]
R-SMAD binding	molecular function	Binding to a receptor-regulated SMAD signaling protein. [GOC:BHF, GOC:vk, PMID:19114992]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
chromatin	cellular component	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]

Involved In

This protein is involved in 5 target(s):

Target	Category	Definition
negative regulation of transcription by RNA polymerase II	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
protein ubiquitination	biological process	The process in which one or more ubiquitin groups are added to a protein. [GOC:ai]
regulation of transforming growth factor beta receptor signaling pathway	biological process	Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway. [GOC:mah]
negative regulation of BMP signaling pathway	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway. [GOC:go_curators]
negative regulation of DNA-templated transcription	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]