Compounds > 2-phenylquinoline
Page last updated: 2024-12-06

2-phenylquinoline

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Description

2-Phenylquinoline is a heterocyclic compound with a quinoline core structure substituted with a phenyl group at the 2-position. It has been extensively studied for its diverse pharmacological activities, including anticancer, antimicrobial, and anti-inflammatory properties. 2-Phenylquinoline derivatives have been investigated as potential drug candidates for a variety of diseases. The synthesis of 2-phenylquinoline typically involves the Friedländer condensation, a reaction between an o-aminobenzaldehyde and an appropriate ketone. 2-Phenylquinoline derivatives have been explored for their potential use in treating cancer, bacterial infections, and inflammatory conditions. The compound's ability to interact with various biological targets, including DNA, enzymes, and receptors, contributes to its pharmacological versatility. Research into 2-phenylquinoline and its derivatives is ongoing, aiming to identify new and more effective therapeutic agents for various diseases.'

2-phenylquinoline: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID71545
CHEMBL ID89786
SCHEMBL ID44999
MeSH IDM0536869

Synonyms (36)

Synonym
CHEMBL89786 ,
BIONET2_001089
quinoline, 2-phenyl-
612-96-4
nsc118137
2-phenylquinoline
.alpha.-phenylquinoline
nsc-118137
smr000112441
MLS001050066
2-phenylquinoline, 99%
HMS1367B11
AKOS005079389
A833138
A25138
NCGC00247631-01
2-phenyl quinoline
quinoline, phenyl-
AE-562/43460146
2-phenyl-quinoline
612-73-7
HMS2269H10
nsc 118137
einecs 210-326-7
SCHEMBL44999
11T-0830
phenylquinoline
P2057
mfcd00011568
DTXSID30210115
CS-W015372
BCP15702
SY041603
FT-0732431
2-phenyl-chinolin
SB66860
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (13)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency50.11870.631035.7641100.0000AID504339
Nrf2Homo sapiens (human)Potency12.58930.09208.222223.1093AID624171
BRCA1Homo sapiens (human)Potency11.22020.89137.722525.1189AID624202
chromobox protein homolog 1Homo sapiens (human)Potency79.43280.006026.168889.1251AID540317
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency20.59620.00419.984825.9290AID504444
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency11.22023.548119.542744.6684AID743266
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)Ki35.00000.00030.86666.6900AID142996
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)Ki35.00000.00030.68056.6900AID142996
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)Ki35.00000.00030.70716.6900AID142996
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)Ki35.00000.00030.81966.6900AID142996
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)Ki35.00000.00030.70726.6900AID142996
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)Ki35.00000.00030.70726.6900AID142996
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)Ki35.00000.00030.70726.6900AID142996
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ceullar Components (2)

Processvia Protein(s)Taxonomy
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)
endoplasmic reticulum membraneGlutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)
plasma membraneGlutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (89)

Assay IDTitleYearJournalArticle
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID363940Antimicrobial activity against Cryptococcus neoformans IM 983036 isolate at 50 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363972Antimicrobial activity against Cryptococcus neoformans IM 052470 isolate at 25 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363945Antimicrobial activity against Cryptococcus neoformans IM 00319 isolate at 50 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363711Antifungal activity against Saccharomyces cerevisiae ATCC 9763 after 48 hrs by broth microdilution technique2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363967Antimicrobial activity against Cryptococcus neoformans IM 961951 isolate at 25 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363710Antifungal activity against Candida albicans ATCC 10231 after 48 hrs by broth microdilution technique2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363960Antimicrobial activity against Cryptococcus neoformans IM 031706 isolate at 50 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363962Antimicrobial activity against Cryptococcus neoformans IM 031706 isolate at 25 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363964Antimicrobial activity against Cryptococcus neoformans IM 031706 isolate at 6.25 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363934Antimicrobial activity against Cryptococcus neoformans IM 042074 isolate at 100 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363957Antimicrobial activity against Cryptococcus neoformans IM 031631 isolate at 12.5 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363776Antimicrobial activity against Cryptococcus neoformans IM 983040 isolate at 50 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363778Antimicrobial activity against Cryptococcus neoformans IM 983040 isolate at 12.5 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363951Antimicrobial activity against Cryptococcus neoformans IM 972751 isolate at 25 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363965Antimicrobial activity against Cryptococcus neoformans IM 961951 isolate at 100 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363941Antimicrobial activity against Cryptococcus neoformans IM 983036 isolate at 25 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363968Antimicrobial activity against Cryptococcus neoformans IM 961951 isolate at 12.5 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363716Antifungal activity against Microsporum gypseum C115 after 48 hrs by broth microdilution technique2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID84649Inhibitory activity against human T-lymphotropic virus type 1 (HTLV-1) infected HUT-102 cells at 10 uM2003Bioorganic & medicinal chemistry letters, Mar-10, Volume: 13, Issue:5
Substituted quinolines induce inhibition of proliferation of HTLV-1 infected cells.
AID363958Antimicrobial activity against Cryptococcus neoformans IM 031631 isolate at 6.25 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363949Antimicrobial activity against Cryptococcus neoformans IM 972751 isolate at 100 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363712Antifungal activity against Cryptococcus neoformans ATCC 32264 after 48 hrs by broth microdilution technique2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363950Antimicrobial activity against Cryptococcus neoformans IM 972751 isolate at 50 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363932Antimicrobial activity against Cryptococcus neoformans IM 972724 isolate at 25 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363715Antifungal activity against Aspergillus niger ATCC 9029 after 48 hrs by broth microdilution technique2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363717Antifungal activity against Trichophyton rubrum C110 after 48 hrs by broth microdilution technique2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363936Antimicrobial activity against Cryptococcus neoformans IM 042074 isolate at 25 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363723Antimicrobial activity against Candida albicans ATCC 10231 at 6.25 ug/ml after 24 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363777Antimicrobial activity against Cryptococcus neoformans IM 983040 isolate at 25 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363954Antimicrobial activity against Cryptococcus neoformans IM 031631 isolate at 100 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363931Antimicrobial activity against Cryptococcus neoformans IM 972724 isolate at 50 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363933Antimicrobial activity against Cryptococcus neoformans IM 972724 isolate at 12.5 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363719Antimicrobial activity against Candida albicans ATCC 10231 at 100 ug/ml after 24 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363774Antimicrobial activity against Cryptococcus neoformans ATCC 32264 at 6.25 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363937Antimicrobial activity against Cryptococcus neoformans IM 042074 isolate at 12.5 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363946Antimicrobial activity against Cryptococcus neoformans IM 00319 isolate at 25 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363974Antimicrobial activity against Cryptococcus neoformans IM 052470 isolate at 6.25 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363963Antimicrobial activity against Cryptococcus neoformans IM 031706 isolate at 12.5 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363953Antimicrobial activity against Cryptococcus neoformans IM 972751 isolate at 6.25 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363970Antimicrobial activity against Cryptococcus neoformans IM 052470 isolate at 100 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363779Antimicrobial activity against Cryptococcus neoformans IM 983040 isolate at 6.25 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363743Antimicrobial activity against Cryptococcus neoformans IM 972724 isolate at 6.25 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363938Antimicrobial activity against Cryptococcus neoformans IM 042074 isolate at 6.25 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID143139The ionization constant for the compound was tested using a potentiometric method.2002Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists.
AID363969Antimicrobial activity against Cryptococcus neoformans IM 961951 isolate at 6.25 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID1890264Antifungal activity against Mucor circinelloides M5 strain assessed as reduction in spore germination at 100 ug/ml relative to control2022Bioorganic & medicinal chemistry letters, 05-01, Volume: 63Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study.
AID550161Binding affinity to Human rhinovirus 2 purified 15N-labeled 3C protease after 50 mins by NMR assay2011Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2
Non-covalent inhibitors of rhinovirus 3C protease.
AID363773Antimicrobial activity against Cryptococcus neoformans ATCC 32264 at 12.5 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363942Antimicrobial activity against Cryptococcus neoformans IM 983036 isolate at 12.5 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363955Antimicrobial activity against Cryptococcus neoformans IM 031631 isolate at 50 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID1890263Antifungal activity against Mucor circinelloides R7B wild type strain assessed as reduction in spore germination at 100 ug/ml relative to control2022Bioorganic & medicinal chemistry letters, 05-01, Volume: 63Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study.
AID363947Antimicrobial activity against Cryptococcus neoformans IM 00319 isolate at 12.5 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363713Antifungal activity against Aspergillus fumigatus ATTC 26934 after 48 hrs by broth microdilution technique2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363770Antimicrobial activity against Cryptococcus neoformans ATCC 32264 at 100 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363722Antimicrobial activity against Candida albicans ATCC 10231 at 12.5 ug/ml after 24 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363966Antimicrobial activity against Cryptococcus neoformans IM 961951 isolate at 50 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363771Antimicrobial activity against Cryptococcus neoformans ATCC 32264 at 50 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363971Antimicrobial activity against Cryptococcus neoformans IM 052470 isolate at 50 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363721Antimicrobial activity against Candida albicans ATCC 10231 at 25 ug/ml after 24 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363952Antimicrobial activity against Cryptococcus neoformans IM 972751 isolate at 12.5 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363959Antimicrobial activity against Cryptococcus neoformans IM 031706 isolate at 100 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363772Antimicrobial activity against Cryptococcus neoformans ATCC 32264 at 25 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363780Antimicrobial activity against Cryptococcus neoformans IM 972724 isolate at 100 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363973Antimicrobial activity against Cryptococcus neoformans IM 052470 isolate at 12.5 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363944Antimicrobial activity against Cryptococcus neoformans IM 00319 isolate at 100 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363956Antimicrobial activity against Cryptococcus neoformans IM 031631 isolate at 25 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363939Antimicrobial activity against Cryptococcus neoformans IM 983036 isolate at 100 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363948Antimicrobial activity against Cryptococcus neoformans IM 00319 isolate at 6.25 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363775Antimicrobial activity against Cryptococcus neoformans IM 983040 isolate at 100 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363718Antifungal activity against Trichophyton mentagrophytes ATCC 9972 after 48 hrs by broth microdilution technique2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363714Antifungal activity against Aspergillus flavus ATCC 9170 after 48 hrs by broth microdilution technique2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID142996Binding affinity against N-methyl-D-aspartate glutamate receptor using [3H]25-6981 as radioligand.2002Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists.
AID363935Antimicrobial activity against Cryptococcus neoformans IM 042074 isolate at 50 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363720Antimicrobial activity against Candida albicans ATCC 10231 at 50 ug/ml after 24 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
AID363943Antimicrobial activity against Cryptococcus neoformans IM 983036 isolate at 6.25 ug/ml after 48 hrs2008Bioorganic & medicinal chemistry, Sep-01, Volume: 16, Issue:17
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (34)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (11.76)18.7374
1990's0 (0.00)18.2507
2000's6 (17.65)29.6817
2010's18 (52.94)24.3611
2020's6 (17.65)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.37

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.37 (24.57)
Research Supply Index3.58 (2.92)
Research Growth Index4.62 (4.65)
Search Engine Demand Index26.67 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.37)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (2.86%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other34 (97.14%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
benzene
[no description available]		7.4110aromatic annulene;
benzenes;
volatile organic compound		carcinogenic agent;
environmental contaminant;
non-polar solvent
formic acid
formic acid: RN given refers to parent cpd. formic acid : The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects.		2.1310monocarboxylic acidantibacterial agent;
astringent;
metabolite;
protic solvent;
solvent
hydrochloric acid
Hydrochloric Acid: A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.. hydrogen chloride : A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms.		2.4920chlorine molecular entity;
gas molecular entity;
hydrogen halide;
mononuclear parent hydride		mouse metabolite
carbonic acid
Carbonic Acid: Carbonic acid (H2C03). The hypothetical acid of carbon dioxide and water. It exists only in the form of its salts (carbonates), acid salts (hydrogen carbonates), amines (carbamic acid), and acid chlorides (carbonyl chloride). (From Grant & Hackh's Chemical Dictionary, 5th ed)		6.9310carbon oxoacid;
chalcocarbonic acid		mouse metabolite
hydrogen
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.		2.110elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
bethanechol
Bethanechol: A slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, HEART RATE changes, and BRONCHIAL SPASM.. bethanechol : The carbamic acid ester of 2-methylcholine. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used as its chloride salt to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention.		2.0510carbamate ester;
quaternary ammonium ion		muscarinic agonist
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		2.610aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
cx546
1-(1,4-benzodioxan-6-ylcarbonyl)piperidine: structure in first source		2.110
fluconazole
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.. fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.		2.4110conazole antifungal drug;
difluorobenzene;
tertiary alcohol;
triazole antifungal drug		environmental contaminant;
P450 inhibitor;
xenobiotic
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		2.4920aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
ketoconazole
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.		2.0410dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine
cinchophen
cinchophen: was heading 1963-94; ACIPHENOCHINOLIUM was see CHINOPHEN 1978-94; use QUINOLINES to search CINCHOPHEN 1966-94		2.6230quinolines
flavone
flavone: RN given refers to unlabeled cpd; structure given in first source. flavone : The simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2.		2.0610flavonesmetabolite;
nematicide
iridium
Iridium: A metallic element with the atomic symbol Ir, atomic number 77, and atomic weight 192.22.		7.1110cobalt group element atom;
platinum group metal atom
deuterium
Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.		2.110dihydrogen
1-deoxynojirimycin
1-deoxy-nojirimycin: structure in first source. duvoglustat : An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration.		2.21102-(hydroxymethyl)piperidine-3,4,5-triol;
piperidine alkaloid		anti-HIV agent;
anti-obesity agent;
bacterial metabolite;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
hepatoprotective agent;
hypoglycemic agent;
plant metabolite
alkenes
[no description available]		2.110
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		7.13101,2,3-triazole
1,2,3,4-tetrahydroquinoline
1,2,3,4-tetrahydroquinoline: structure in first source. 1,2,3,4-tetrahydroquinoline : A member of the class of quinolines that is the 1,2,3,4-tetrahydro derivative of quinoline.		2.110quinolines
2-n-propylquinoline
2-propylquinoline: structure in first source		2.0110
fullerene c60
Fullerenes: A polyhedral CARBON structure composed of around 60-80 carbon atoms in pentagon and hexagon configuration. They are named after Buckminster Fuller because of structural resemblance to geodesic domes. Fullerenes can be made in high temperature such as arc discharge in an inert atmosphere.. fullerene : A compound composed solely of an even number of carbon atoms, which form a cage-like fused-ring polycyclic system with twelve five-membered rings and the rest six-membered rings. The term has been broadened to include any closed cage structure consisting entirely of three-coordinate carbon atoms.		3.5620fullerenegeroprotector
2-phenyl-4-oxohydroquinoline
2-phenyl-4-oxohydroquinoline: structure given in first source		2.0610
Dubamine
[no description available]		2.0410quinolines
glucosamine
D-glucosamine : An amino sugar whose structure comprises D-glucose having an amino substituent at position 2.. 2-amino-2-deoxy-D-glucopyranose : A D-glucosamine whose structure comprises D-glucopyranose having an amino substituent at position 2.		2.2110D-glucosamineEscherichia coli metabolite;
geroprotector;
mouse metabolite
afimoxifene
afimoxifene : A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.		2.0610phenols;
tertiary amino compound		antineoplastic agent;
estrogen receptor antagonist;
metabolite
terbinafine
[no description available]		2.0410acetylenic compound;
allylamine antifungal drug;
enyne;
naphthalenes;
tertiary amine		EC 1.14.13.132 (squalene monooxygenase) inhibitor;
P450 inhibitor;
sterol biosynthesis inhibitor
tamoxifen
[no description available]		2.0610stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
amphotericin b
Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.		2.0410antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
styrylquinoline
styrylquinoline: structure in first source		2.01102-styrylquinoline
olaparib
[no description available]		2.110cyclopropanes;
monofluorobenzenes;
N-acylpiperazine;
phthalazines		antineoplastic agent;
apoptosis inducer;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor
piperidines
Piperidines: A family of hexahydropyridines.		2.110
ConditionIndicatedRelationship StrengthStudiesTrials
Human T-lymphotropic Virus 1 Infection
[description not available]		02.0110
Cell Transformation, Viral
An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.		02.0110
HTLV-I Infections
Diseases caused by HUMAN T-LYMPHOTROPIC VIRUS 1.		02.0110
Innate Inflammatory Response
[description not available]		02.0510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0510
Catarrh
Inflammation of a mucous membrane with increased flow of mucous in humans or animals. Catarrh is used mostly in a historical context.		02.0610
Infections, Picornaviridae
[description not available]		02.0610
Common Cold
A catarrhal disorder of the upper respiratory tract, which may be viral or a mixed infection. It generally involves a runny nose, nasal congestion, and sneezing.		02.0610
Mucorales Infection
[description not available]		02.4110
Mucormycosis
Infection in humans and animals caused by any fungus in the order MUCORALES (e.g., RHIZOPUS; MUCOR; CUNNINGHAMELLA; APOPHYSOMYCES; ABSIDIA; SAKSENAEA and RHIZOMUCOR) There are many clinical types associated with infection including central nervous system, lung, gastrointestinal tract, skin, orbit and paranasal sinuses. In humans, it usually occurs as an OPPORTUNISTIC INFECTION.		02.4110
Infections, Staphylococcal
[description not available]		02.6920
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS.		02.6920
Gastric Ulcer
[description not available]		02.4920
Stomach Ulcer
Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).		02.4920
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.0510
Ache
[description not available]		02.0510
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.		02.0510
Breast Cancer
[description not available]		02.0610
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.0610
Polyarthritis
[description not available]		02.3320
Rheumatoid Arthritis
[description not available]		02.3320
Arthritis, Degenerative
[description not available]		01.9310
Rheumatism
[description not available]		01.9310
Arthritis
Acute or chronic inflammation of JOINTS.		02.3320
Arthritis, Rheumatoid
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.		02.3320
Osteoarthritis
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.		01.9310
Rheumatic Diseases
Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement.		06.9310