histamine has been researched along with Pain in 241 studies
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral administration of morphine caused analgesia without modulating itch intensities but increased neurogenic inflammation in response to histamine, suggesting that different opioid mechanisms in histaminergic and non-histaminergic neurons evoke neurogenic inflammation." | 9.69 | Effects of oral morphine on experimentally evoked itch and pain: a randomized, double-blind, placebo-controlled trial. ( Ammitzbøll, N; Arendt-Nielsen, L; Drewes, AM; Lo Vecchio, S; Okutani, H, 2023) |
| "Diacerein (DCN), an analogue of rhein (a glycosidal compound of natural origin), is currently used in the treatment of osteoarthritis and is given a fast-track designation for development to treat epidermolysis bullosa (EB)." | 9.22 | Therapeutic Potential of Diacerein in Management of Pain. ( Jain, M; Joharapurkar, A; Patel, V, 2022) |
| "Cowhage, capsaicin and histamine, all applied via spicules, were used to induce itch and pain-related sensations in 15 male and 15 female subjects." | 9.20 | Gender differences in itch and pain-related sensations provoked by histamine, cowhage and capsaicin. ( Forster, C; Handwerker, HO; Hartmann, EM, 2015) |
| " Immediately after the injection of 100 µg histamine on both arms, subjects received topical treatment and pruritus was subsequently assessed with visual analogue scale (VASpruritus) and Eppendorfer questionnaire." | 9.20 | A double-blind, randomized clinical study to determine the efficacy of benzocaine 10% on histamine-induced pruritus and UVB-light induced slight sunburn pain. ( Bauer, M; Lang-Zwosta, I; Nishino, K; Scherzer, T; Schwameis, R; Zeitlinger, M, 2015) |
| "We tested the hypothesis that the solvent for etomidate was a factor in the incidence of pain and other side effects after injection, and that these were associated with histamine release." | 9.09 | Solvent for etomidate may cause pain and adverse effects. ( Doenicke, AW; Hoernecke, R; Lorenz, W; Ostwald, P; Roizen, MF, 1999) |
| "A quantitative comparison was made of the effect of infiltration of local analgesics and topical analgesic cream (EMLA) on laser-induced pain and histamine-induced wheal, flare and itch." | 9.06 | A quantitative comparison of the effect of local analgesics on argon laser induced cutaneous pain and on histamine induced wheal, flare and itch. ( Arendt-Nielsen, L; Bjerring, P, 1990) |
| "Capsaicin nanoparticles could be useful in reducing pain and itch associated with pruritic diseases that are histamine-independent." | 8.12 | Topical Capsaicin in Poly(lactic-co-glycolic)acid (PLGA) Nanoparticles Decreases Acute Itch and Heat Pain. ( Chen, Z; Escamilla-Rivera, V; Jung, S; LaMotte, RH; Malewicz, NM; Oeck, S; Rattray, Z; Tang, X; Zhou, J, 2022) |
| "This study investigated whether itch induced by intra-epidermal histamine is subjected to modulation by a standardized conditioned pain modulation (CPM) paradigm in 24 healthy volunteers." | 7.83 | Conditioning pain stimulation does not affect itch induced by intra-epidermal histamine pricks but aggravates neurogenic inflammation in healthy volunteers. ( Andersen, HH; Arendt-Nielsen, L; Elberling, J; Imai, Y; Koenig, J; Petersen, KK, 2016) |
| "The present study was aimed to investigate the effects of microinjection of histamine and its H1, H2 and H3 receptor antagonists, mepyramine, ranitidine and thioperamide, respectively, into the anterior cingulate cortex (ACC) on pain-related behaviors induced by formalin in rats." | 7.81 | Effects of microinjection of histamine into the anterior cingulate cortex on pain-related behaviors induced by formalin in rats. ( Farshid, AA; Hamzeh-Gooshchi, N; Tamaddonfard, E, 2015) |
| "To date, suggestions that endothelin-1 (ET-1) causes nociception and pruritus are based on results in preclinical models in which responses to pruritic and nociceptive stimuli cannot be distinguished." | 7.78 | Endothelin-1 induces itch and pain in the mouse cheek model. ( Gomes, LO; Hara, DB; Rae, GA, 2012) |
| "Histamine and calcitonin gene-related peptide (CGRP) contribute to the pain perception." | 7.77 | Interaction of histamine and calcitonin gene-related peptide in the formalin induced pain perception in rats. ( Ghasri, S; Hamzely, A; Khoshkholgh Sima, B; Mobarakeh, JI; Nezhad, RM; Nunoki, K; Rahimi, AA; Takahashi, K; Torkaman-Boutorabi, A; Yanai, K, 2011) |
| "Both manual acupuncture and histamine injection of ST 36 can relieve pain in AIA rats, which may be closely related to its effect in activating mast cells in acupoint area." | 7.76 | [Acupoint-injection of histamine induced analgesic effect in acute adjuvant-induced-arthritis rats]. ( Ding, GH; Huang, M; Xie, YY, 2010) |
| "These data demonstrate that mast cells promote cystitis pain and bladder pathophysiology through the separable actions of histamine and TNF, respectively." | 7.74 | Mast cell-derived histamine mediates cystitis pain. ( Berry, RE; Bryce, PJ; Guichelaar, LA; Klumpp, DJ; Rudick, CN, 2008) |
| " The present study examined the effects of combinations of dextromethorphan and ketamine, two clinically used N-methyl-D-aspartate (NMDA) receptor antagonists, with amitriptyline on formalin-evoked behaviors and paw edema." | 7.72 | Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats. ( Reid, A; Sawynok, J, 2003) |
| "Possible central serotonergic and histaminergic modulation of acute peripheral inflammation was investigated in rats, adopting the formaldehyde-induced acute pedal inflammation as an experimental model." | 7.69 | Central serotonergic and histaminergic modulation of peripheral inflammation and nociception in rats. ( Dumka, VK; Raviprakash, V; Tandan, SK; Tripathi, HC, 1996) |
| "The effect of menthol and alcohol as its vehicle on thermal sensations, pain, experimental itch and irritation were studied in 18 subjects, using a computerized thermal sensory analyzer, laser Doppler flowmetry and an evaporimeter for transepidermal water loss (TEWL)." | 7.69 | Effect of topically applied menthol on thermal, pain and itch sensations and biophysical properties of the skin. ( Hui, XY; Maibach, H; Szolar, C; Yosipovitch, G, 1996) |
| "Deep muscle pain is often associated with sensory changes in the corresponding dermatome." | 6.71 | Interaction between histamine-induced itch and experimental muscle pain. ( Baron, R; Binder, A; Jensen, TS; Schattschneider, J; Schwarz, K; Wasner, G, 2004) |
| "Oral administration of morphine caused analgesia without modulating itch intensities but increased neurogenic inflammation in response to histamine, suggesting that different opioid mechanisms in histaminergic and non-histaminergic neurons evoke neurogenic inflammation." | 5.69 | Effects of oral morphine on experimentally evoked itch and pain: a randomized, double-blind, placebo-controlled trial. ( Ammitzbøll, N; Arendt-Nielsen, L; Drewes, AM; Lo Vecchio, S; Okutani, H, 2023) |
| "Radiation-induced acute oral mucositis is associated with inflammation and pain." | 5.62 | Early radiation-induced oral pain signaling responses are reduced with pentoxifylline treatment. ( Lai, YE; Lascelles, BDX; Marcus, KL; Nolan, MW; Price, ML; Robertson, JB, 2021) |
| "Diacerein (DCN), an analogue of rhein (a glycosidal compound of natural origin), is currently used in the treatment of osteoarthritis and is given a fast-track designation for development to treat epidermolysis bullosa (EB)." | 5.22 | Therapeutic Potential of Diacerein in Management of Pain. ( Jain, M; Joharapurkar, A; Patel, V, 2022) |
| "Cowhage, capsaicin and histamine, all applied via spicules, were used to induce itch and pain-related sensations in 15 male and 15 female subjects." | 5.20 | Gender differences in itch and pain-related sensations provoked by histamine, cowhage and capsaicin. ( Forster, C; Handwerker, HO; Hartmann, EM, 2015) |
| " Immediately after the injection of 100 µg histamine on both arms, subjects received topical treatment and pruritus was subsequently assessed with visual analogue scale (VASpruritus) and Eppendorfer questionnaire." | 5.20 | A double-blind, randomized clinical study to determine the efficacy of benzocaine 10% on histamine-induced pruritus and UVB-light induced slight sunburn pain. ( Bauer, M; Lang-Zwosta, I; Nishino, K; Scherzer, T; Schwameis, R; Zeitlinger, M, 2015) |
| " Histamine always provoked itching and rarely pain, capsaicin always pain but never itching." | 5.10 | Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens. ( Handwerker, HO; Hilliges, M; Schmelz, M; Schmidt, R; Torebjork, HE; Weidner, C, 2003) |
| "We tested the hypothesis that the solvent for etomidate was a factor in the incidence of pain and other side effects after injection, and that these were associated with histamine release." | 5.09 | Solvent for etomidate may cause pain and adverse effects. ( Doenicke, AW; Hoernecke, R; Lorenz, W; Ostwald, P; Roizen, MF, 1999) |
| "We investigated the effects of tactile allodynia on the itch and mechanically evoked dysesthesiae produced by an intradermal injection of histamine in human volunteers." | 5.09 | Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia. ( Atanassoff, PG; Brull, SJ; Lamotte, RH; Silverman, DG; Zhang, J, 1999) |
| "We have studied experimentally induced itch (using histamine iontophoresis) and pain (using topical mustard oil) in healthy human volunteers, measured using visual analogue scale (VAS) ratings." | 5.08 | A comparison of the effects of noxious and innocuous counterstimuli on experimentally induced itch and pain. ( McMahon, SB; Ward, L; Wright, E, 1996) |
| "The effect of psychological pain reduction on the cutaneous inflammatory process was investigated by studying the effect of hypnotically induced analgesia on the flare reaction of cutaneous histamine prick tests." | 5.06 | The effect of hypnotically induced analgesia on flare reaction of the cutaneous histamine prick test. ( Bjerring, P; Zachariae, R, 1990) |
| "A quantitative comparison was made of the effect of infiltration of local analgesics and topical analgesic cream (EMLA) on laser-induced pain and histamine-induced wheal, flare and itch." | 5.06 | A quantitative comparison of the effect of local analgesics on argon laser induced cutaneous pain and on histamine induced wheal, flare and itch. ( Arendt-Nielsen, L; Bjerring, P, 1990) |
| "Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| "Capsaicin nanoparticles could be useful in reducing pain and itch associated with pruritic diseases that are histamine-independent." | 4.12 | Topical Capsaicin in Poly(lactic-co-glycolic)acid (PLGA) Nanoparticles Decreases Acute Itch and Heat Pain. ( Chen, Z; Escamilla-Rivera, V; Jung, S; LaMotte, RH; Malewicz, NM; Oeck, S; Rattray, Z; Tang, X; Zhou, J, 2022) |
| " Anti-inflammatory activity was determined by the carrageenan-induced and histamine-induce Rat paw edema in rats, analgesic activity was determined by acetic acid-Induced writhing test, formalin-induced hind paw licking in mice and Tail immersion test." | 4.12 | Evaluation of anti-inflammatory and analgesic effects of Hertia intermedia (Boiss.) Kuntze extract. ( Arslan, M; Iqbal, J; Jabbar, A; Jan, SU; Khan, Z; Mehjabeen, -; Muhammad, S; Qadir, A; Shah, PA; Soomer Khan, N; Younis, M, 2022) |
| "Short-lasting tingling dermal pain appears immediately upon exposure to sweating stimuli, regardless of developing eruptions and/or presence of hypohidrosis, but possibly in association with sweat and plasma histamine." | 4.12 | Clinical and histological characterization of transient dermal pain triggered by sweating stimuli. ( Harada, N; Hide, M; Ishii, K; Mizuno, H; Okamoto, M; Takahagi, S; Tanaka, A; Yanagida, N, 2022) |
| " Compared to the naïve mice, a significant increase in itch-related behaviors was observed in the CCD mice after the injection of pruritogens including histamine and BAM8-22, but not after the injection of capsaicin, although all the above agents evoked enhanced pain-related behaviors toward the injected site." | 4.02 | The role of pruriceptors in enhancing sensitivity to pruritogens in a murine chronic compression model of dorsal root ganglion. ( Fang, Y; Ma, C; Tao, J; Wang, T, 2021) |
| " For mechanism investigation, it was used hot plate test to induce opioid receptors, a histamine and serotonin test to induce edema paw, finally, for the TRPV1 receptor, it was used the capsaicin test." | 4.02 | Pharmacological studies on aqueous extract of Launaea arborescens from southwest Algeria. ( Belboukhari, N; Cheriti, A; Ould El Hadj-Khelil, A; Seddiki, LS; Sekkoum, K; Sulaiman, MR, 2021) |
| "Although TRPA1, SP, histamine and 5-hydroxytryptamine (5-HT) have recognized contribution to nociceptive mechanisms, little is known about how they interact with each other to mediate inflammatory pain in vivo." | 3.85 | TRPA1, substance P, histamine and 5-hydroxytryptamine interact in an interdependent way to induce nociception. ( de Oliveira Borges, M; Fischer, L; Lavoranti, MI; Martynhak, BJ; Miksza, AF; Parada, CA; Sardi, NF; Tambeli, CH, 2017) |
| "We conclude that activation of mechano-insensitive nociceptors is sufficient to provoke itch by histamine- and acid-induced pain." | 3.83 | Mechano-sensitive nociceptors are required to detect heat pain thresholds and cowhage itch in human skin. ( Benrath, J; Dusch, M; Ringkamp, M; Rukwied, R; Schmelz, M; van der Ham, J; Weinkauf, B, 2016) |
| "This study investigated whether itch induced by intra-epidermal histamine is subjected to modulation by a standardized conditioned pain modulation (CPM) paradigm in 24 healthy volunteers." | 3.83 | Conditioning pain stimulation does not affect itch induced by intra-epidermal histamine pricks but aggravates neurogenic inflammation in healthy volunteers. ( Andersen, HH; Arendt-Nielsen, L; Elberling, J; Imai, Y; Koenig, J; Petersen, KK, 2016) |
| " At same doses, SP-Ul was tested on Wistar rats on paw edema elicited by different irritants (carrageenan, dextran, bradykinin, histamine or serotonin)." | 3.83 | Analgesic and anti-inflammatory actions on bradykinin route of a polysulfated fraction from alga Ulva lactuca. ( Benevides, NM; Bezerra, MM; Chaves, HV; de Araújo, IW; de Sousa Oliveira Vanderlei, E; Maciel, GF; Pereira, KM; Quinderé, AL; Ribeiro, KA; Ribeiro, NA; Rodrigues, JA; Silva, JF, 2016) |
| "The present study was aimed to investigate the effects of microinjection of histamine and its H1, H2 and H3 receptor antagonists, mepyramine, ranitidine and thioperamide, respectively, into the anterior cingulate cortex (ACC) on pain-related behaviors induced by formalin in rats." | 3.81 | Effects of microinjection of histamine into the anterior cingulate cortex on pain-related behaviors induced by formalin in rats. ( Farshid, AA; Hamzeh-Gooshchi, N; Tamaddonfard, E, 2015) |
| " The PLS (30 mg kg(-1)) significantly reduced the paw oedema induced by carrageenan, dextran, histamine and serotonin and also was able to significantly inhibit leucocyte migration into the peritoneal cavity and decrease the concentration of myeloperoxidase (MPO) in paw tissue." | 3.80 | Polysaccharide isolated from Agardhiella ramosissima: chemical structure and anti-inflammation activity. ( Barbosa, AL; Batista, JA; Brito, TV; Chaves, LS; de Paula, RC; Dias, EG; Feitosa, JP; Freitas, AL; Medeiros, JV; Melo, MR; Prudêncio, RS; Ribeiro, RA; Silva, RO; Souza, MH, 2014) |
| " & Naudin (Ss-EtOH) in the experimental models of edema induced by carrageenan, dextran, or histamin and nociception induced by chemical stimuli, such as acetic acid, formalin, capsaicin, or glutamate." | 3.80 | Anti-inflammatory and antinociceptive effects of Sterculia striata A. St.-Hil. & Naudin (Malvaceae) in rodents. ( Almeida, FR; Amaral, MP; Chaves, MH; Costa, DA; Figueiredo, KA; Júnior, FB; Oliveira, FA; Oliveira, IS; Oliveira, RC; Silva, FV, 2014) |
| " in wistar rats 1 hr before carrageenan, dextran, histamine or serotonin, were tested in paw oedema models." | 3.80 | Peripheral antinociception and anti-inflammatory effects of sulphated polysaccharides from the alga Caulerpa mexicana. ( Benevides, NM; Bezerra, MM; Carneiro, JG; Chaves, HV; Coura, CO; de Araújo, IW; de Sousa Oliveira Vanderlei, E; Quinderé, AL; Rodrigues, JA; Souza, RB, 2014) |
| "Intrathecal application of morphine is among the most powerful methods used to treat severe chronic pain." | 3.79 | Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons. ( Giesler, GJ; Moser, HR, 2013) |
| " Moreover, similar to wild-type littermates, Nf1± mice developed inflammation-induced heat and mechanical hypersensitivity, capsaicin-induced nocifensive behavior, histamine-dependent or -independent scratching, and chronic constriction injury-induced cold allodynia." | 3.79 | Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1. ( Brenner, DS; Gereau, RW; Gutmann, DH; O'Brien, DE, 2013) |
| "To date, suggestions that endothelin-1 (ET-1) causes nociception and pruritus are based on results in preclinical models in which responses to pruritic and nociceptive stimuli cannot be distinguished." | 3.78 | Endothelin-1 induces itch and pain in the mouse cheek model. ( Gomes, LO; Hara, DB; Rae, GA, 2012) |
| "The anti-oedemogenic activity of the hydroalcoholic extract of the roots of Byttneria herbacea (HBH) was evaluated against carrageenan and histamine induced rat paw oedema, acetic acid induced writhing and histamine induced vascular permeability in mice." | 3.78 | A report on anti-oedemogenic activity of Byttneria herbacea roots--possible involvement of histamine receptor (type I). ( Bhuvaneswari, N; Fukui, H; Islam, MN; Karmakar, S; Mizuguchi, H; Samanta, SK; Sarkar, L; Sen, T, 2012) |
| " Nevertheless, the anti-inflammatory activity was tested in carrageenan induced paw edema and histamine induced inflammatory tests." | 3.78 | Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant. ( Khan, H; Muhammad, N; Saeed, M, 2012) |
| " CETD was evaluated for anti-inflammatory activity in experimental acute (carrageenan-, histamine- and serotonin-induced paw oedema) and chronic models (cotton pellet-induced granuloma) in Wistar albino rats." | 3.78 | Protective role of the triterpenoid-enriched extract of Trichosanthes dioica root against experimentally induced pain and inflammation in rodents. ( Bhattacharya, S; Haldar, PK, 2012) |
| " Itch and pain were induced using the following somatosensory stimuli: electrical stimulation, histamine iontophoresis and the cold pressor test." | 3.78 | Role of induced negative and positive emotions in sensitivity to itch and pain in women. ( Evers, AW; Kraaimaat, FW; Kroeze, S; van de Kerkhof, PC; van Laarhoven, AI; van Riel, PL; Walker, AL; Wilder-Smith, OH, 2012) |
| "Histamine and calcitonin gene-related peptide (CGRP) contribute to the pain perception." | 3.77 | Interaction of histamine and calcitonin gene-related peptide in the formalin induced pain perception in rats. ( Ghasri, S; Hamzely, A; Khoshkholgh Sima, B; Mobarakeh, JI; Nezhad, RM; Nunoki, K; Rahimi, AA; Takahashi, K; Torkaman-Boutorabi, A; Yanai, K, 2011) |
| " To this end, electrical stimuli were applied before and after histamine application (HPCS) to female patients with psoriasis and healthy female control subjects." | 3.76 | Heterotopic pruritic conditioning and itch--analogous to DNIC in pain? ( Evers, AWM; Kraaimaat, FW; van de Kerkhof, PCM; van Laarhoven, AIM; Wilder-Smith, OH, 2010) |
| "Both manual acupuncture and histamine injection of ST 36 can relieve pain in AIA rats, which may be closely related to its effect in activating mast cells in acupoint area." | 3.76 | [Acupoint-injection of histamine induced analgesic effect in acute adjuvant-induced-arthritis rats]. ( Ding, GH; Huang, M; Xie, YY, 2010) |
| " These mice showed profound scratching deficits in response to all of the itching (pruritogenic) stimuli tested, irrespective of their histamine dependence." | 3.75 | Cellular basis of itch sensation. ( Chen, ZF; Liu, XY; Meng, XL; Sun, YG; Yin, J; Zhao, ZQ, 2009) |
| " Austroplenckia populnea bark hydroalcoholic crude extract, and its hexane, chloroform and ethyl acetate fractions, obtained by partition, as well as the isolated populnoic acid were investigated for their anti-inflammatory (carrageenan, dextran and histamine-induced rat paw oedema, histamine-induced increase in vascular permeability, and granulomatous tissue induction) and analgesic activities (writhing and hot plate tests)." | 3.74 | Anti-inflammatory and antinociceptive activities of extract, fractions and populnoic acid from bark wood of Austroplenckia populnea. ( Andrade, SF; Bastos, JK; Cardoso, LG; Carvalho, JC, 2007) |
| " For evaluation of inflammation carrageenan-, histamine- and serotonin-induced paw edema served as acute models and formaldehyde-induced arthritis served as a chronic model in rats." | 3.74 | Antinociceptive and anti-inflammatory effects of Thespesia populnea bark extract. ( Gunnam, KK; Parle, M; Vasudevan, M, 2007) |
| "These data demonstrate that mast cells promote cystitis pain and bladder pathophysiology through the separable actions of histamine and TNF, respectively." | 3.74 | Mast cell-derived histamine mediates cystitis pain. ( Berry, RE; Bryce, PJ; Guichelaar, LA; Klumpp, DJ; Rudick, CN, 2008) |
| " indica dry extract (100, 200 and 400 mg kg-1) exhibited dose dependent and significant anti-inflammatory activity in acute (carrageenean and histamine induced hind paw oedema, p < 0." | 3.74 | Anti-inflammatory and anti-nociceptive activities of Fumaria indica whole plant extract in experimental animals. ( Gupta, PK; Rao, CV; Verma, AR; Vijayakumar, M, 2007) |
| " To study the participation of histamine in pain perception, histidine decarboxylase knockout mice were examined for pain threshold by means of three different kinds of noxious stimuli: thermal nociception (hot-plate, tail-flick, and paw-withdrawal), mechanical nociception (tail-pressure), and chemical nociception (formalin test and capsaicin test)." | 3.73 | Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: a study in histidine decarboxylase gene knockout mice. ( Kato, M; Kuramasu, A; Mobarakeh, JI; Orito, T; Sakurada, S; Sakurai, E; Yanai, K; Yoshida, A, 2005) |
| "Role in pain sensation of both nociceptin (NC), the bioactive heptadecapeptide sequence of preproorphaninFQ and of histamine has been widely evidenced in the central nervous system (CNS)." | 3.73 | [Effect of nociceptin on histamine and serotonin release in the central nervous system]. ( Gyenge, M; Hantos, M; Laufer, R; Tekes, K, 2006) |
| " The present study examined the effects of combinations of dextromethorphan and ketamine, two clinically used N-methyl-D-aspartate (NMDA) receptor antagonists, with amitriptyline on formalin-evoked behaviors and paw edema." | 3.72 | Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats. ( Reid, A; Sawynok, J, 2003) |
| "Dried leaves extract from Bouchea fluminensis was assessed in anti-inflammatory (mouse paw edema) and analgesic models (acetic acid-induced writhings and hot plate)." | 3.72 | Anti-inflammatory and analgesic activity of Bouchea fluminensis. ( Costa, VB; Coube, CS; Fernandes, PD; Leitão, SG; Marinho, BG; Matheus, ME, 2003) |
| "5, 5 and 10 mg kg (-1)) was investigated and compared with diclofenac sodium (5 mg kg (-1)) using the formalin-, histamine-, and carrageenan-induced paw oedema and cotton pellet granuloma tests." | 3.71 | Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice. ( Büyükokuroğlu, ME, 2002) |
| "Nicotine evokes pain in the skin and oral mucosa and excites a subpopulation of cutaneous nociceptors, but little is known about the central transmission of chemogenic pain." | 3.70 | Activation of spinal wide dynamic range neurons by intracutaneous microinjection of nicotine. ( Carstens, E; Jinks, SL, 1999) |
| "Pain-producing concentrations of capsaicin (30-300 ng/ml) were applied to the nasal mucosal surface both before and late into the pollen season." | 3.69 | Effects of topical capsaicin in seasonal allergic rhinitis. ( Andersson, M; Greiff, L; Persson, CG; Svensson, C, 1995) |
| "The effect of menthol and alcohol as its vehicle on thermal sensations, pain, experimental itch and irritation were studied in 18 subjects, using a computerized thermal sensory analyzer, laser Doppler flowmetry and an evaporimeter for transepidermal water loss (TEWL)." | 3.69 | Effect of topically applied menthol on thermal, pain and itch sensations and biophysical properties of the skin. ( Hui, XY; Maibach, H; Szolar, C; Yosipovitch, G, 1996) |
| "Sympathetic reflex responses were elicited in human volunteers by sustained selective excitation of nociceptors by noxious chemicals, namely topical application of mustard oil which elicited burning pain, or histamine which induced itching in a skin area of 5 cm2 on the volar aspect of one forearm." | 3.69 | Asymmetry and time-course of cutaneous sympathetic reflex responses following sustained excitation of chemosensitive nociceptors in humans. ( Handwerker, HO; Koltzenburg, M; Magerl, W; Schmitz, JM, 1996) |
| "Possible central serotonergic and histaminergic modulation of acute peripheral inflammation was investigated in rats, adopting the formaldehyde-induced acute pedal inflammation as an experimental model." | 3.69 | Central serotonergic and histaminergic modulation of peripheral inflammation and nociception in rats. ( Dumka, VK; Raviprakash, V; Tandan, SK; Tripathi, HC, 1996) |
| "Time course of plasma extravasation in neurogenic inflammation elicited by histamine iontophoresis and topical capsaicin application was measured in vivo by a modified intradermal microdialysis technique in humans." | 3.69 | Plasma extravasation and neuropeptide release in human skin as measured by intradermal microdialysis. ( Averbeck, B; Bickel, A; Luz, O; Schmelz, M, 1997) |
| "Data have been collected indicating possible functions for histamine in brain but there are only a very few data, collected exclusively with behavioural tests, about the effects of histamine on the perception of the pain, an important aspect in the homeostasis of the human body." | 3.68 | Electrophysiological correlates for antinociceptive effects of histamine after intracerebral administration to the rat. ( Braga, PC; Guidobono, E; Netti, C; Pecile, A; Sibilia, V, 1992) |
| "The investigation of algoinductor (histaminergic) and peptidergic relations in peripheral pain reaction of taste was performed by using of different histamine liberators (applied on tongue)." | 3.68 | [Role of pain component in the organization of chemosensory taste reaction]. ( Liubimova, ZV; Marinova, TIu; Nikitina, AA; Subrakova, SA, 1991) |
| " Histamine was iontophoretically applied to the receptive fields of these units for 20 or 30 s and was found to provoke itching sensations lasting several minutes, together with wheal and flare responses." | 3.68 | Discharge patterns of human C-fibers induced by itching and burning stimuli. ( Forster, C; Handwerker, HO; Kirchhoff, C, 1991) |
| "Intraarterial injection of histamine into the isolated perfused rabbit ear causes a reflex fall in mean arterial blood pressure by stimulation of perivascular pain receptors." | 3.66 | Dependence of histamine-evoked nociception on prostaglandin release. ( Juan, H, 1981) |
| " In order to determine the nervous outflow from skeletal muscle during chemically induced muscle pain, the impulse activity of various types of muscle afferents in response to close intra-arterial injections of pain-producing substances (bradykinin, 5-hydroxytryptamine, histamine and potassium) was studied in anaesthetized cats using a single fibre recording technique." | 3.65 | Nervous outflow from skeletal muscle following chemical noxious stimulation. ( Mense, S, 1977) |
| "Because pain has been more extensively studied, some extrapolations to itch can be proposed and verified by experiments." | 2.72 | Itch processing in the brain. ( Ben Salem, D; Carré, JL; Dufor, O; Misery, L; Najafi, P, 2021) |
| "Deep muscle pain is often associated with sensory changes in the corresponding dermatome." | 2.71 | Interaction between histamine-induced itch and experimental muscle pain. ( Baron, R; Binder, A; Jensen, TS; Schattschneider, J; Schwarz, K; Wasner, G, 2004) |
| "Itch and pain were scored on a visual analogue scale at regular intervals." | 2.70 | Topically applied aspirin decreases histamine-induced wheal and flare reactions in normal and SLS-inflamed skin, but does not decrease itch. A randomized, double-blind and placebo-controlled human study. ( Benfeldt, E; Jensen, SB; Menné, T; Serup, J; Thomsen, JS, 2002) |
| "Histamine 10 microl was injected into each bleb, and the resulting magnitude of itch estimated." | 2.69 | Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia. ( Atanassoff, PG; Brull, SJ; Greenquist, K; Lamotte, RH; Silverman, DG; Zhang, J, 1999) |
| "Headache is the most prominent and clinically important symptom of migraine but its origin is still enigmatic." | 2.45 | Migraine: where and how does the pain originate? ( Messlinger, K, 2009) |
| "Itch (pruritus) is a sensory phenomenon characterized by a (usually) negative affective component and the initiation of a special behavioral act, i." | 2.44 | TRP channels as novel players in the pathogenesis and therapy of itch. ( Bíró, T; Dobrosi, N; Géczy, T; Marincsák, R; Paus, R; Tóth, BI, 2007) |
| "Atopic dermatitis is often associated with increased pain." | 1.91 | Crisaborole Inhibits Itch and Pain by Preventing Neutrophil Infiltration in a Mouse Model of Atopic Dermatitis. ( Akiyama, T; Bystrom, L; Ishida, H; Markan, A; Pavlenko, D; Todurga Seven, Z; Verpile, R, 2023) |
| "Although itch and pain have many similarities, they are completely different in perceptual experience and behavioral response." | 1.91 | Microglia are involved in regulating histamine-dependent and non-dependent itch transmissions with distinguished signal pathways. ( Li, BM; Liu, Y; Liu, YU; Ma, CL; Mou, B; Pan, H; Peng, J; Xiong, MT; Yang, Y; Yun, X; Zhang, JY; Zhang, QR; Zhao, HX, 2023) |
| "Radiation-induced acute oral mucositis is associated with inflammation and pain." | 1.62 | Early radiation-induced oral pain signaling responses are reduced with pentoxifylline treatment. ( Lai, YE; Lascelles, BDX; Marcus, KL; Nolan, MW; Price, ML; Robertson, JB, 2021) |
| "PmV also induced hyperalgesia in both mice and rats, evaluated through electronic von Frey and rat paw pressure test, respectively." | 1.48 | Potamotrygon motoro stingray venom induces both neurogenic and inflammatory pain behavior in rodents. ( Barbaro, KC; Kimura, LF; Picolo, G; Santos-Neto, M, 2018) |
| "Chronic pain affects the lives of millions yearly, but few new treatments are available." | 1.46 | A novel zebrafish-based model of nociception. ( DeBerry, JJ; Dewberry, LS; Sorge, RE; Taylor, JC; Totsch, SK; Watts, SA; Yessick, LR, 2017) |
| " tragacantha exhibited anti-inflammatory and analgesic properties and they are also safe for medicinal use." | 1.43 | Phytochemical screening, safety evaluation, anti-inflammatory and analgesic studies of the leaf extracts of Sterculia tragacantha. ( Abatan, MO; Adedapo, AA; Mogbojuri, OM, 2016) |
| "Systemic mastocytosis is characterised by abnormal proliferation of mast cells in various organs." | 1.42 | [Vulvar oedema revealing systemic mastocytosis]. ( Aubin, F; Daguindau, E; Deveza, E; Girardin, M; Humbert, P; Locatelli, F; Pelletier, F; Valmary-Degano, S, 2015) |
| "Edema was evaluated by the increase in articular diameter (AD; mm), and PL was measured by the amount of Evans blue dye in the synovial fluid (PL; μg/mL)." | 1.39 | Histamine produces opposing effects to serotonin in the knee joint of rats. ( de Oliveira, DT; Eto, C; Souza-Silva, E; Stein, T; Tonussi, CR, 2013) |
| "treatment with histamine increased the phosphorylation of the NR1 subunit of N-methyl-D-aspartate (NMDA) receptors." | 1.37 | Involvement of glial cells in the nociceptive behaviors induced by a high-dose of histamine administered intrathecally. ( Iwata, Y; Katsuyama, S; Komatsu, T; Mizoguchi, H; Onodera, K; Orito, T; Sakurada, S; Sakurada, T; Watanabe, C; Watanabe, H; Yonezawa, A, 2011) |
| "Central neuropathic pain following lesions within the CNS, such as spinal cord injury, is one of the most excruciating types of chronic pain and one of the most difficult to treat." | 1.35 | Residual spinothalamic tract pathways predict development of central pain after spinal cord injury. ( Engel, S; Lee, BB; McLachlan, E; Wasner, G, 2008) |
| "(AR) has been used to treat pain and inflammation in Korea." | 1.32 | Mechanism of anti-nociceptive effects of Asarum sieboldii Miq. radix: potential role of bradykinin, histamine and opioid receptor-mediated pathways. ( Gao Zhang, C; Kim, SJ; Taek Lim, J, 2003) |
| "The ability of allergens to induce hyperalgesia in immunoglobulin E (IgE)-sensitized rats was investigated." | 1.32 | Combined action of vasoactive amines and bradykinin mediates allergen-evoked thermal hyperalgesia in rats. ( Calixto, JB; Cordeiro, RS; e Silva, PM; Lavich, TR; Martins, MA, 2003) |
| "Histamine has an antinociceptive effect in the brain and may be involved in opioid-induced analgesia." | 1.31 | Opposite modulation of histaminergic neurons by nociceptin and morphine. ( Eriksson, KS; Haas, HL; Stevens, DR, 2000) |
| "Diquat treatment increased the MMC number." | 1.31 | Chronic low-level administration of diquat increases the nociceptive response to gastric distension in rats: role of mast cells and tachykinin receptor activation. ( Anton, PM; Bueno, L; Fioramonti, J; Theodorou, V, 2001) |
| "Kyotorphin is a dipeptidic neuropeptide (tyrosine-arginine) that has specific receptor coupled to G(i) and phospholipase C and elicits Met-enkephalin release." | 1.31 | In vivo signal transduction of nociceptive response by kyotorphin (tyrosine-arginine) through Galpha(i)- and inositol trisphosphate-mediated Ca(2+) influx. ( Inoue, M; Ueda, H, 2000) |
| " The dose-response function was extremely steep, however, since other doses showed either no effect or behavioral toxicity." | 1.30 | Antinociceptive activity of impentamine, a histamine congener, after CNS administration. ( Hough, LB; Leurs, R; Menge, WM; Nalwalk, JW; Timmerman, H, 1999) |
| "Histamine was injected when the skin reaction was on the wane to determine its possible reactivation of inflammation." | 1.27 | [Reactivation of the algogenic component in experimental inflammation induced by histamine administration]. ( Chiarini, P; Duranti, R; Galletti, R; Guazzelli, R; Matassi, L; Strazzulla, G, 1983) |
| " Dose-response studies indicate that bradykinin is more potent than serotonin or histamine in respect of wealing." | 1.25 | Responses of skin blood vessels to bradykinin, histamine and 5-hydroxytryptamine. ( Greaves, M; Shuster, S, 1967) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 86 (35.68) | 18.7374 |
| 1990's | 34 (14.11) | 18.2507 |
| 2000's | 49 (20.33) | 29.6817 |
| 2010's | 52 (21.58) | 24.3611 |
| 2020's | 20 (8.30) | 2.80 |
| Authors | Studies |
|---|---|
| Takahagi, S | 1 |
| Okamoto, M | 1 |
| Ishii, K | 1 |
| Tanaka, A | 1 |
| Mizuno, H | 1 |
| Harada, N | 1 |
| Yanagida, N | 1 |
| Hide, M | 1 |
| Malewicz, NM | 2 |
| Ieong, HF | 1 |
| Oeck, S | 2 |
| Kumowski, N | 1 |
| Zhang, Z | 1 |
| Shimada, SG | 3 |
| LaMotte, RH | 6 |
| Rattray, Z | 1 |
| Jung, S | 1 |
| Escamilla-Rivera, V | 1 |
| Chen, Z | 1 |
| Tang, X | 1 |
| Zhou, J | 1 |
| Seldeslachts, A | 1 |
| Peigneur, S | 1 |
| Mebs, D | 1 |
| Tytgat, J | 1 |
| Younis, M | 1 |
| Iqbal, J | 1 |
| Muhammad, S | 1 |
| Jan, SU | 1 |
| Jabbar, A | 1 |
| Mehjabeen, - | 1 |
| Qadir, A | 1 |
| Soomer Khan, N | 1 |
| Arslan, M | 1 |
| Shah, PA | 1 |
| Khan, Z | 1 |
| Patel, V | 1 |
| Joharapurkar, A | 1 |
| Jain, M | 1 |
| Lindgren, E | 1 |
| Strote, J | 1 |
| Wang, J | 2 |
| Lu, C | 1 |
| Liu, X | 1 |
| Zhang, G | 1 |
| Zhang, J | 3 |
| Gao, M | 1 |
| Liu, D | 1 |
| Zhang, X | 1 |
| Liu, Y | 2 |
| Asgharieh-Ahari, M | 1 |
| Tamaddonfard, E | 2 |
| Erfanparast, A | 1 |
| Soltanalinejad-Taghiabad, F | 1 |
| Zuo, Y | 1 |
| Wan, R | 1 |
| Jiang, P | 1 |
| Chen, X | 1 |
| Li, L | 1 |
| Hua, W | 1 |
| Yang, Y | 1 |
| Mou, B | 1 |
| Zhang, QR | 1 |
| Zhao, HX | 1 |
| Zhang, JY | 1 |
| Yun, X | 1 |
| Xiong, MT | 1 |
| Liu, YU | 1 |
| Pan, H | 1 |
| Ma, CL | 1 |
| Li, BM | 1 |
| Peng, J | 1 |
| Pavlenko, D | 1 |
| Todurga Seven, Z | 1 |
| Bystrom, L | 1 |
| Markan, A | 1 |
| Verpile, R | 1 |
| Ishida, H | 1 |
| Akiyama, T | 3 |
| Okutani, H | 1 |
| Lo Vecchio, S | 2 |
| Ammitzbøll, N | 1 |
| Drewes, AM | 1 |
| Arendt-Nielsen, L | 4 |
| Ganchingco, JRC | 1 |
| Fukuyama, T | 1 |
| Yoder, JA | 1 |
| Bäumer, W | 1 |
| Alvaro, CG | 1 |
| Braz, JM | 1 |
| Bernstein, M | 1 |
| Hamel, KA | 1 |
| Craik, V | 1 |
| Yamanaka, H | 1 |
| Basbaum, AI | 1 |
| Barry, DM | 1 |
| Liu, XT | 1 |
| Liu, B | 1 |
| Liu, XY | 2 |
| Gao, F | 1 |
| Zeng, X | 1 |
| Liu, J | 1 |
| Yang, Q | 1 |
| Wilhelm, S | 1 |
| Yin, J | 2 |
| Tao, A | 1 |
| Chen, ZF | 3 |
| Najafi, P | 1 |
| Dufor, O | 1 |
| Ben Salem, D | 1 |
| Misery, L | 1 |
| Carré, JL | 1 |
| Price, ML | 1 |
| Lai, YE | 1 |
| Marcus, KL | 1 |
| Robertson, JB | 1 |
| Lascelles, BDX | 1 |
| Nolan, MW | 1 |
| Wang, T | 2 |
| Tao, J | 1 |
| Fang, Y | 1 |
| Ma, C | 2 |
| Seddiki, LS | 1 |
| Belboukhari, N | 1 |
| Ould El Hadj-Khelil, A | 1 |
| Sulaiman, MR | 1 |
| Sekkoum, K | 1 |
| Cheriti, A | 1 |
| Graceffa, RF | 1 |
| Boezio, AA | 1 |
| Able, J | 1 |
| Altmann, S | 1 |
| Berry, LM | 1 |
| Boezio, C | 1 |
| Butler, JR | 1 |
| Chu-Moyer, M | 1 |
| Cooke, M | 1 |
| DiMauro, EF | 1 |
| Dineen, TA | 1 |
| Feric Bojic, E | 1 |
| Foti, RS | 1 |
| Fremeau, RT | 1 |
| Guzman-Perez, A | 1 |
| Gao, H | 1 |
| Gunaydin, H | 1 |
| Huang, H | 1 |
| Huang, L | 1 |
| Ilch, C | 1 |
| Jarosh, M | 1 |
| Kornecook, T | 1 |
| Kreiman, CR | 1 |
| La, DS | 1 |
| Ligutti, J | 1 |
| Milgram, BC | 1 |
| Lin, MJ | 1 |
| Marx, IE | 1 |
| Nguyen, HN | 1 |
| Peterson, EA | 1 |
| Rescourio, G | 1 |
| Roberts, J | 1 |
| Schenkel, L | 1 |
| Shimanovich, R | 1 |
| Sparling, BA | 1 |
| Stellwagen, J | 1 |
| Taborn, K | 1 |
| Vaida, KR | 1 |
| Yeoman, J | 1 |
| Yu, V | 1 |
| Zhu, D | 1 |
| Moyer, BD | 1 |
| Weiss, MM | 1 |
| Andersen, HH | 2 |
| Elberling, J | 2 |
| Yosipovitch, G | 5 |
| Kimura, LF | 1 |
| Santos-Neto, M | 1 |
| Barbaro, KC | 1 |
| Picolo, G | 1 |
| Lipshetz, B | 1 |
| Khasabov, SG | 1 |
| Truong, H | 1 |
| Netoff, TI | 1 |
| Simone, DA | 1 |
| Giesler, GJ | 2 |
| Roberts, CA | 1 |
| Giesbrecht, T | 1 |
| Stancak, A | 1 |
| Fallon, N | 1 |
| Thomas, A | 1 |
| Kirkham, TC | 1 |
| Bartsch, VB | 1 |
| Niehaus, JK | 1 |
| Taylor-Blake, B | 2 |
| Zylka, MJ | 2 |
| Moser, HR | 1 |
| O'Brien, DE | 1 |
| Brenner, DS | 1 |
| Gutmann, DH | 1 |
| Gereau, RW | 1 |
| Souza-Silva, E | 1 |
| de Oliveira, DT | 1 |
| Eto, C | 1 |
| Stein, T | 1 |
| Tonussi, CR | 1 |
| Roberson, DP | 1 |
| Gudes, S | 1 |
| Sprague, JM | 1 |
| Patoski, HA | 1 |
| Robson, VK | 1 |
| Blasl, F | 1 |
| Duan, B | 1 |
| Oh, SB | 1 |
| Bean, BP | 1 |
| Ma, Q | 1 |
| Binshtok, AM | 1 |
| Woolf, CJ | 1 |
| van Laarhoven, AI | 4 |
| Kraaimaat, FW | 5 |
| Wilder-Smith, OH | 5 |
| van Riel, PL | 2 |
| van de Kerkhof, PC | 2 |
| Evers, AW | 4 |
| Batista, JA | 1 |
| Dias, EG | 1 |
| Brito, TV | 1 |
| Prudêncio, RS | 1 |
| Silva, RO | 1 |
| Ribeiro, RA | 1 |
| Souza, MH | 1 |
| de Paula, RC | 1 |
| Feitosa, JP | 1 |
| Chaves, LS | 1 |
| Melo, MR | 1 |
| Freitas, AL | 1 |
| Medeiros, JV | 1 |
| Barbosa, AL | 1 |
| Silva, FV | 1 |
| Oliveira, IS | 1 |
| Figueiredo, KA | 1 |
| Júnior, FB | 1 |
| Costa, DA | 1 |
| Chaves, MH | 1 |
| Amaral, MP | 1 |
| Almeida, FR | 1 |
| Oliveira, FA | 1 |
| Oliveira, RC | 1 |
| Nagamine, M | 1 |
| Carstens, MI | 2 |
| Carstens, E | 4 |
| Carneiro, JG | 1 |
| Rodrigues, JA | 2 |
| de Sousa Oliveira Vanderlei, E | 2 |
| Souza, RB | 1 |
| Quinderé, AL | 2 |
| Coura, CO | 1 |
| de Araújo, IW | 2 |
| Chaves, HV | 2 |
| Bezerra, MM | 2 |
| Benevides, NM | 2 |
| Hartmann, EM | 1 |
| Handwerker, HO | 10 |
| Forster, C | 3 |
| Funahashi, H | 1 |
| Naono-Nakayama, R | 1 |
| Ebihara, K | 1 |
| Koganemaru, G | 1 |
| Kuramashi, A | 1 |
| Ikeda, T | 1 |
| Nishimori, T | 1 |
| Ishida, Y | 1 |
| Bauer, M | 1 |
| Schwameis, R | 1 |
| Scherzer, T | 1 |
| Lang-Zwosta, I | 1 |
| Nishino, K | 1 |
| Zeitlinger, M | 1 |
| Weinkauf, B | 1 |
| Dusch, M | 1 |
| van der Ham, J | 1 |
| Benrath, J | 1 |
| Ringkamp, M | 2 |
| Schmelz, M | 10 |
| Rukwied, R | 2 |
| Hamzeh-Gooshchi, N | 1 |
| Farshid, AA | 1 |
| Deveza, E | 1 |
| Locatelli, F | 1 |
| Girardin, M | 1 |
| Valmary-Degano, S | 1 |
| Daguindau, E | 1 |
| Aubin, F | 1 |
| Humbert, P | 1 |
| Pelletier, F | 1 |
| Peerdeman, KJ | 1 |
| Donders, AR | 1 |
| Hopman, MT | 1 |
| Peters, ML | 1 |
| Chuquilin, M | 1 |
| Alghalith, Y | 1 |
| Fernandez, KH | 1 |
| Yuan, T | 1 |
| Li, J | 1 |
| Shen, L | 1 |
| Zhang, W | 1 |
| Xu, Y | 1 |
| Zhu, J | 1 |
| Huang, Y | 1 |
| Sutherland, S | 1 |
| Mogbojuri, OM | 1 |
| Adedapo, AA | 1 |
| Abatan, MO | 1 |
| Imai, Y | 1 |
| Petersen, KK | 1 |
| Koenig, J | 1 |
| Silva, JF | 1 |
| Maciel, GF | 1 |
| Ribeiro, NA | 1 |
| Ribeiro, KA | 1 |
| Pereira, KM | 1 |
| Fischer, L | 2 |
| Lavoranti, MI | 1 |
| de Oliveira Borges, M | 1 |
| Miksza, AF | 1 |
| Sardi, NF | 1 |
| Martynhak, BJ | 1 |
| Tambeli, CH | 4 |
| Parada, CA | 4 |
| Taylor, JC | 1 |
| Dewberry, LS | 1 |
| Totsch, SK | 1 |
| Yessick, LR | 1 |
| DeBerry, JJ | 1 |
| Watts, SA | 1 |
| Sorge, RE | 1 |
| Namer, B | 1 |
| Carr, R | 1 |
| Johanek, LM | 1 |
| Wasner, G | 3 |
| Lee, BB | 1 |
| Engel, S | 1 |
| McLachlan, E | 1 |
| Messlinger, K | 1 |
| Sikand, P | 1 |
| Green, BG | 1 |
| Sun, YG | 1 |
| Zhao, ZQ | 1 |
| Meng, XL | 1 |
| Murotani, T | 1 |
| Ishizuka, T | 1 |
| Nakazawa, H | 1 |
| Wang, X | 1 |
| Mori, K | 1 |
| Sasaki, K | 1 |
| Ishida, T | 1 |
| Yamatodani, A | 1 |
| Maruani, A | 1 |
| Vierron, E | 1 |
| Machet, L | 1 |
| Giraudeau, B | 1 |
| Boucaud, A | 1 |
| Kajihara, Y | 1 |
| Murakami, M | 1 |
| Imagawa, T | 1 |
| Otsuguro, K | 1 |
| Ito, S | 1 |
| Ohta, T | 1 |
| Wojtecka-Lukasik, E | 1 |
| Ksiezopolska-Orlowska, K | 1 |
| Gaszewska, E | 1 |
| Krasowicz-Towalska, O | 1 |
| Rzodkiewicz, P | 1 |
| Maslinska, D | 1 |
| Szukiewicz, D | 1 |
| Maslinski, S | 1 |
| Stadel, R | 1 |
| Carpenter, AB | 1 |
| Nalwalk, JW | 3 |
| de Esch, IJ | 1 |
| Janssen, E | 1 |
| Hough, LB | 4 |
| van Laarhoven, AIM | 2 |
| van de Kerkhof, PCM | 2 |
| Evers, AWM | 2 |
| Huang, M | 1 |
| Xie, YY | 1 |
| Ding, GH | 1 |
| Lagerström, MC | 1 |
| Rogoz, K | 1 |
| Abrahamsen, B | 1 |
| Persson, E | 1 |
| Reinius, B | 1 |
| Nordenankar, K | 1 |
| Olund, C | 1 |
| Smith, C | 1 |
| Mendez, JA | 1 |
| Wood, JN | 1 |
| Wallén-Mackenzie, A | 1 |
| Kullander, K | 1 |
| Mizoguchi, H | 3 |
| Komatsu, T | 2 |
| Iwata, Y | 2 |
| Watanabe, C | 3 |
| Watanabe, H | 3 |
| Orito, T | 4 |
| Katsuyama, S | 2 |
| Yonezawa, A | 3 |
| Onodera, K | 3 |
| Sakurada, T | 3 |
| Sakurada, S | 4 |
| Vogelaar, ML | 1 |
| van Riel, PLCM | 1 |
| Hoffmeister, C | 1 |
| Trevisan, G | 1 |
| Rossato, MF | 1 |
| de Oliveira, SM | 1 |
| Gomez, MV | 1 |
| Ferreira, J | 1 |
| Mobarakeh, JI | 3 |
| Torkaman-Boutorabi, A | 1 |
| Rahimi, AA | 1 |
| Ghasri, S | 1 |
| Nezhad, RM | 1 |
| Hamzely, A | 1 |
| Khoshkholgh Sima, B | 1 |
| Takahashi, K | 1 |
| Nunoki, K | 1 |
| Yanai, K | 4 |
| Bhattacharya, S | 1 |
| Haldar, PK | 1 |
| Sarkar, L | 1 |
| Bhuvaneswari, N | 1 |
| Samanta, SK | 1 |
| Islam, MN | 1 |
| Sen, T | 1 |
| Fukui, H | 2 |
| Mizuguchi, H | 1 |
| Karmakar, S | 1 |
| Walker, AL | 1 |
| Kroeze, S | 1 |
| Gomes, LO | 1 |
| Hara, DB | 1 |
| Rae, GA | 1 |
| Muhammad, N | 1 |
| Saeed, M | 1 |
| Khan, H | 1 |
| McCoy, ES | 1 |
| Büyükokuroğlu, ME | 1 |
| Lavich, TR | 1 |
| Cordeiro, RS | 1 |
| Calixto, JB | 1 |
| e Silva, PM | 1 |
| Martins, MA | 1 |
| Schmidt, R | 2 |
| Weidner, C | 2 |
| Hilliges, M | 2 |
| Torebjork, HE | 2 |
| Sawynok, J | 1 |
| Reid, A | 1 |
| Costa, VB | 1 |
| Coube, CS | 1 |
| Marinho, BG | 1 |
| Matheus, ME | 1 |
| Leitão, SG | 1 |
| Fernandes, PD | 1 |
| Kim, SJ | 2 |
| Gao Zhang, C | 1 |
| Taek Lim, J | 1 |
| Krylova, SG | 1 |
| Razina, TG | 1 |
| Zueva, EP | 1 |
| Amosova, EN | 1 |
| Shilova, NV | 1 |
| Dugina, YL | 1 |
| Epstein, OI | 1 |
| JACOB, J | 1 |
| SZERB, J | 1 |
| HOBBIGER, F | 1 |
| GALLETTI, R | 4 |
| ARCANGELI, P | 2 |
| SKOUBY, AP | 1 |
| HANSEL, FK | 1 |
| ROSENTHAL, SR | 4 |
| BRUMMER, P | 1 |
| BORNEMISZA, G | 2 |
| CSALAY, L | 2 |
| HORVATH, G | 2 |
| LUDANY, G | 2 |
| STERN, P | 4 |
| HUKOVIC, S | 3 |
| BESAROVIC, Z | 1 |
| SPUZIC, I | 1 |
| RYVKINA, DE | 1 |
| KUZNETSOVA, NE | 1 |
| MOULTON, R | 1 |
| SPECTOR, WG | 1 |
| WILLOUGHBY, DA | 1 |
| SZIRMAI, E | 1 |
| DE WIED, D | 1 |
| JINKS, R | 1 |
| SPECKMANN, K | 2 |
| MOECKEL, W | 1 |
| COLLIER, HO | 3 |
| LEE, IR | 1 |
| TEODORESCU, P | 1 |
| SAVULESCU, V | 1 |
| ANDRONACHE, I | 1 |
| FODOR, O | 1 |
| MIKI, I | 1 |
| BROADBENT, JL | 1 |
| MARRA, N | 1 |
| VECCHIET, L | 1 |
| Ikoma, A | 3 |
| Fartasch, M | 1 |
| Heyer, G | 1 |
| Miyachi, Y | 3 |
| Handwerker, H | 3 |
| MACKEY, WA | 1 |
| MUFSON, I | 1 |
| KLEINBAUM, H | 1 |
| Schwarz, K | 2 |
| Schattschneider, J | 2 |
| Binder, A | 1 |
| Jensen, TS | 1 |
| Baron, R | 4 |
| GIRARD, M | 1 |
| FRAISSE, H | 1 |
| Yoshida, A | 1 |
| Sakurai, E | 1 |
| Kuramasu, A | 1 |
| Kato, M | 1 |
| Fast, K | 1 |
| Bernhard, JD | 1 |
| Hosogi, M | 1 |
| Vasudevan, M | 1 |
| Gunnam, KK | 1 |
| Parle, M | 1 |
| Andrade, SF | 1 |
| Cardoso, LG | 1 |
| Carvalho, JC | 1 |
| Bastos, JK | 1 |
| Gyenge, M | 1 |
| Hantos, M | 1 |
| Laufer, R | 1 |
| Tekes, K | 1 |
| Bíró, T | 1 |
| Tóth, BI | 1 |
| Marincsák, R | 1 |
| Dobrosi, N | 1 |
| Géczy, T | 1 |
| Paus, R | 1 |
| Mochizuki, H | 1 |
| Sadato, N | 1 |
| Saito, DN | 1 |
| Toyoda, H | 1 |
| Tashiro, M | 1 |
| Okamura, N | 1 |
| Ting, E | 1 |
| Roveroni, RC | 1 |
| Ferrari, LF | 1 |
| Lotufo, CM | 1 |
| Veiga, MC | 1 |
| Herde, L | 1 |
| Strupf, M | 1 |
| Watanabe, S | 1 |
| Hattori, T | 1 |
| Kanazawa, M | 1 |
| Kano, M | 1 |
| Fukudo, S | 1 |
| Norbury, TA | 1 |
| MacGregor, AJ | 1 |
| Urwin, J | 1 |
| Spector, TD | 1 |
| McMahon, SB | 2 |
| Ishiuji, Y | 1 |
| Coghill, RC | 1 |
| Patel, TS | 1 |
| Dawn, A | 1 |
| Fountain, J | 1 |
| Oshiro, Y | 1 |
| Rao, CV | 1 |
| Verma, AR | 1 |
| Gupta, PK | 1 |
| Vijayakumar, M | 1 |
| Rudick, CN | 1 |
| Bryce, PJ | 1 |
| Guichelaar, LA | 1 |
| Berry, RE | 1 |
| Klumpp, DJ | 1 |
| Keele, CA | 3 |
| Kaplan, HR | 1 |
| Wolke, RE | 1 |
| Malone, MH | 1 |
| Greaves, M | 1 |
| Shuster, S | 1 |
| Agnoli, A | 1 |
| Denaro, A | 1 |
| Ceci, E | 1 |
| Falaschi, P | 1 |
| Juan, H | 2 |
| Terenius, L | 1 |
| Sweet, WH | 1 |
| Monsereenusorn, Y | 1 |
| Kongsamut, S | 1 |
| Pezalla, PD | 1 |
| Chiarini, P | 2 |
| Duranti, R | 1 |
| Strazzulla, G | 1 |
| Guazzelli, R | 1 |
| Matassi, L | 2 |
| Terman, GW | 1 |
| Shavit, Y | 1 |
| Lewis, JW | 1 |
| Cannon, JT | 1 |
| Liebeskind, JC | 1 |
| Van Hees, J | 1 |
| Gybels, J | 1 |
| Kuraishi, Y | 1 |
| Nagasawa, T | 1 |
| Hayashi, K | 1 |
| Satoh, M | 1 |
| Dray, A | 1 |
| Greiff, L | 1 |
| Svensson, C | 1 |
| Andersson, M | 1 |
| Persson, CG | 1 |
| Feldmann, R | 1 |
| Lindner, V | 1 |
| Saguer, M | 1 |
| Cambareri, JJ | 1 |
| Afifi, MS | 1 |
| Glass, PS | 1 |
| Esposito, BF | 1 |
| Camporesi, EM | 1 |
| Koltzenburg, M | 2 |
| Rajakulasingam, K | 1 |
| Polosa, R | 1 |
| Lau, LC | 1 |
| Church, MK | 1 |
| Holgate, ST | 1 |
| Howarth, PH | 1 |
| Koppert, W | 1 |
| Reeh, PW | 1 |
| Szolar, C | 2 |
| Hui, XY | 2 |
| Maibach, H | 2 |
| Lamberti, C | 1 |
| Bartolini, A | 1 |
| Ghelardini, C | 1 |
| Malmberg-Aiello, P | 1 |
| Magerl, W | 1 |
| Schmitz, JM | 1 |
| Ward, L | 1 |
| Wright, E | 1 |
| Dumka, VK | 1 |
| Tandan, SK | 1 |
| Tripathi, HC | 1 |
| Raviprakash, V | 1 |
| Luz, O | 1 |
| Averbeck, B | 1 |
| Bickel, A | 1 |
| Birklein, F | 1 |
| Claus, D | 1 |
| Riedl, B | 1 |
| Neundörfer, B | 1 |
| Leurs, R | 1 |
| Menge, WM | 1 |
| Timmerman, H | 1 |
| Su, X | 1 |
| Wachtel, RE | 1 |
| Gebhart, GF | 1 |
| Jinks, SL | 2 |
| Ueda, H | 1 |
| Inoue, M | 1 |
| Atanassoff, PG | 2 |
| Brull, SJ | 2 |
| Greenquist, K | 1 |
| Silverman, DG | 2 |
| Doenicke, AW | 1 |
| Roizen, MF | 1 |
| Hoernecke, R | 1 |
| Lorenz, W | 1 |
| Ostwald, P | 1 |
| Eriksson, KS | 1 |
| Stevens, DR | 1 |
| Haas, HL | 1 |
| Harasawa, K | 1 |
| Kim, MS | 1 |
| Cunha, FQ | 1 |
| Ferreira, SH | 2 |
| Anton, PM | 1 |
| Theodorou, V | 1 |
| Fioramonti, J | 1 |
| Bueno, L | 1 |
| Drzezga, A | 1 |
| Darsow, U | 1 |
| Treede, RD | 2 |
| Siebner, H | 1 |
| Frisch, M | 1 |
| Munz, F | 1 |
| Weilke, F | 1 |
| Ring, J | 1 |
| Schwaiger, M | 1 |
| Bartenstein, P | 1 |
| Kashiba, H | 1 |
| Senba, E | 1 |
| Lischetzki, G | 1 |
| Kleinert, A | 1 |
| Olsen, UB | 1 |
| Eltorp, CT | 1 |
| Ingvardsen, BK | 1 |
| Jørgensen, TK | 1 |
| Lundbaek, JA | 1 |
| Thomsen, C | 1 |
| Hansen, AJ | 1 |
| Thomsen, JS | 2 |
| Sonne, M | 1 |
| Benfeldt, E | 2 |
| Jensen, SB | 2 |
| Serup, J | 2 |
| Menné, T | 2 |
| Ørstavik, K | 1 |
| Torebjörk, E | 1 |
| Greenberg, S | 1 |
| Palmer, GC | 1 |
| Sewell, RD | 1 |
| Spencer, PS | 1 |
| Peacock, EE | 1 |
| Mense, S | 3 |
| Greenbaum, LM | 1 |
| Nishi, K | 1 |
| Sakanashi, M | 1 |
| Takenaka, F | 1 |
| Loux, JJ | 1 |
| Smith, S | 1 |
| Salem, H | 1 |
| Greaves, MW | 1 |
| Corti, F | 1 |
| Hiss, E | 1 |
| Hui, KS | 1 |
| Ivey, KJ | 1 |
| Khayutin, VM | 1 |
| Baraz, LA | 1 |
| Lukoshkova, EV | 1 |
| Sonina, RS | 1 |
| Chernilovskaya, PE | 1 |
| Simons, FE | 1 |
| Gillespie, CA | 1 |
| Simons, KJ | 1 |
| Braga, PC | 1 |
| Sibilia, V | 1 |
| Guidobono, E | 1 |
| Pecile, A | 1 |
| Netti, C | 1 |
| Seltzer, Z | 1 |
| Paran, Y | 1 |
| Eisen, A | 1 |
| Ginzburg, R | 1 |
| Subrakova, SA | 1 |
| Liubimova, ZV | 1 |
| Marinova, TIu | 1 |
| Nikitina, AA | 1 |
| Kirchhoff, C | 1 |
| Oluyomi, AO | 1 |
| Hart, SL | 1 |
| Bjerring, P | 3 |
| Zachariae, R | 1 |
| Himmelfarb, GN | 1 |
| Schumilowa, IJ | 1 |
| Klimczak, J | 1 |
| Manni, E | 1 |
| Draicchio, F | 1 |
| Pettorossi, VE | 1 |
| Carobi, C | 1 |
| Grassi, S | 1 |
| Bortolami, R | 1 |
| Lucchi, ML | 1 |
| Glick, SD | 1 |
| Su, K | 1 |
| Broton, JG | 2 |
| Sessle, BJ | 2 |
| Hu, JW | 1 |
| Martin, J | 1 |
| Pinsky, L | 1 |
| DiGeorge, AM | 1 |
| Kane, J | 1 |
| Downie, AW | 1 |
| Marcotte, DB | 1 |
| Perez-Reyes, M | 1 |
| Belcher, RW | 1 |
| Czarnetzki, BM | 1 |
| Carney, JF | 1 |
| Gardner, E | 1 |
| Avis, HH | 1 |
| Lembeck, F | 1 |
| James, GW | 1 |
| Schneider, C | 1 |
| Inoki, R | 1 |
| Garcia Leme, J | 1 |
| Lico, M | 1 |
| Fordtran, JS | 1 |
| Morawski, SG | 1 |
| Richardson, CT | 1 |
| Jannetta, PJ | 1 |
| Amery, A | 1 |
| Bossaert, H | 1 |
| Deruyttere, M | 1 |
| Vanderlinden, L | 1 |
| Verstraete, M | 1 |
| Schmidt, RF | 1 |
| Popkin, RJ | 1 |
| Makarov, PO | 1 |
| Safronova, LG | 1 |
| Musto, P | 1 |
| Barile, C | 1 |
| Graziani, M | 1 |
| Gütz, HJ | 1 |
| Berndt, H | 1 |
| Wolff, G | 1 |
| Goldor, H | 1 |
| Zaffiri, O | 1 |
| Del Prete, D | 1 |
| Staldi, GF | 1 |
| Taira, N | 1 |
| Nakayama, K | 1 |
| Hashimoto, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Organ Protective Effect of Histamine H1 Receptor Antagonist In Patients With Severe Burns: A Clinical Study[NCT06126991] | Phase 1/Phase 2 | 32 participants (Anticipated) | Interventional | 2023-11-01 | Recruiting | ||
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| Genetic, Epigenetic, Psychosocial, and Biological Determinants of Post-surgical Pain After Pectus or Spine Surgery[NCT04031716] | 600 participants (Anticipated) | Interventional | 2018-07-06 | Enrolling by invitation | |||
| Impact of Photobiomodulation on Pain During Orthodontic Treatment[NCT05361616] | 50 participants (Anticipated) | Interventional | 2023-04-17 | Recruiting | |||
| A Randomized Controlled Trial Evaluating Three Non-invasive Analgesic Techniques in Pain Prevention During Injections[NCT03974633] | Phase 4 | 100 participants (Actual) | Interventional | 2018-02-24 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
23 reviews available for histamine and Pain
| Article | Year |
|---|---|
Therapeutic Potential of Diacerein in Management of Pain.
Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cytokines; Glutamates; Histam | 2022 |
The seven day itch: A delayed histamine reaction to stingray injury.
Topics: Animals; Bites and Stings; Histamine; Humans; Pain; Skates, Fish; Water | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Itch processing in the brain.
Topics: Brain; Histamine; Humans; Mucuna; Pain; Pruritus | 2021 |
Where Is Itch Represented in the Brain, and How Does it Differ from Pain? An Activation Likelihood Estimation Meta-Analysis of Experimentally-Induced Itch.
Topics: Adult; Allergens; Brain Mapping; Cluster Analysis; Diagnosis, Differential; Electric Stimulation; Fe | 2019 |
Neurocutaneous disease: Cutaneous neuroanatomy and mechanisms of itch and pain.
Topics: Analgesics, Opioid; Animals; Calcineurin; Histamine; Humans; Neural Pathways; Pain; Peptide Hydrolas | 2016 |
Assessment of Itch and Pain in Animal Models and Human Subjects.
Topics: Analgesics; Animals; Antipruritics; Avoidance Learning; Capsaicin; Conditioning, Classical; Emotions | 2016 |
Migraine: where and how does the pain originate?
Topics: Animals; Calcitonin Gene-Related Peptide; Headache; Histamine; Humans; Meninges; Migraine Disorders; | 2009 |
TRP channels as novel players in the pathogenesis and therapy of itch.
Topics: Animals; Cannabinoids; Capsaicin; Central Nervous System; Histamine; Humans; Inflammation Mediators; | 2007 |
Biochemical mediators in pain.
Topics: Antidepressive Agents; Bradykinin; Endorphins; Histamine; Humans; Nociceptors; Pain; Prostaglandins; | 1981 |
Animal models of chronic pain: their possible validation from human experience with posterior rhizotomy and congenital analgesia (Part I of the second John J. Bonica lecture).
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Chronic Disease; Cordotomy; Disease Models, Ani | 1981 |
Capsaicin--a literature survey.
Topics: Analgesia; Animals; Blood Pressure; Body Temperature Regulation; Capsaicin; Cardiovascular System; C | 1982 |
Inflammatory mediators of pain.
Topics: Adenosine Triphosphate; Cytokines; Histamine; Humans; Inflammation; Inflammation Mediators; Kinins; | 1995 |
Itch--mediators and mechanisms.
Topics: Antipruritics; Histamine; Humans; Models, Biological; Neurons; Nociceptors; Opioid Peptides; Pain; P | 2002 |
The role of biogenic agents in the actions of centrally-acting analgesics.
Topics: Acetylcholine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bio | 1977 |
Histamine as the chemical mediator for cutaneous pain.
Topics: Animals; Cornea; Female; Histamine; Histamine H1 Antagonists; Histamine Release; Humans; Injections, | 1977 |
Physiology of skin.
Topics: Animals; Histamine; Humans; Lymph; Pain; Prostaglandins E; Prostaglandins F; Pruritus; Receptors, Ad | 1976 |
Anticholinergics: do they work in peptic ulcer?
Topics: Acute Disease; Antacids; Clinical Trials as Topic; Drug Therapy, Combination; Gastric Juice; Gastric | 1975 |
Pruritus.
Topics: Cholestasis, Intrahepatic; Endopeptidases; Endorphins; Histamine; Humans; Kidney Failure, Chronic; N | 1985 |
Chemical causes of pain and itch.
Topics: Arthritis; Cholestasis; Drug Eruptions; Histamine; Histamine Release; Humans; Muscular Diseases; Pai | 1970 |
The neuropharmacology of aggression: a critical review.
Topics: Acetylcholine; Aggression; Animals; Appetitive Behavior; Behavior, Animal; Brain Chemistry; Catechol | 1974 |
[Mechanics of actions of analgesics--especially on peripheral actions].
Topics: Acetylcholine; Analgesics; Animals; Bradykinin; Catecholamines; Chemoreceptor Cells; Drug Synergism; | 1973 |
A pharmacological analysis of aspirin.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Blood Chemical Analysis; Bradykinin; Bronchi | 1969 |
27 trials available for histamine and Pain
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effects of oral morphine on experimentally evoked itch and pain: a randomized, double-blind, placebo-controlled trial.
Topics: Analgesics, Opioid; Histamine; Humans; Morphine; Neurogenic Inflammation; Pain; Pruritus | 2023 |
Gender differences in itch and pain-related sensations provoked by histamine, cowhage and capsaicin.
Topics: Adult; Capsaicin; Female; Germany; Histamine; Humans; Laser-Doppler Flowmetry; Male; Mucuna; Pain; P | 2015 |
A double-blind, randomized clinical study to determine the efficacy of benzocaine 10% on histamine-induced pruritus and UVB-light induced slight sunburn pain.
Topics: Administration, Topical; Adult; Benzocaine; Double-Blind Method; Histamine; Humans; Male; Ointments; | 2015 |
Inducing Expectations for Health: Effects of Verbal Suggestion and Imagery on Pain, Itch, and Fatigue as Indicators of Physical Sensitivity.
Topics: Adolescent; Cold Temperature; Electrocardiography; Exercise; Fatigue; Female; Heart Rate; Histamine; | 2015 |
Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage.
Topics: Area Under Curve; Capsaicin; Dose-Response Relationship, Drug; Female; Histamine; Humans; Incidence; | 2009 |
Efficiency of low-frequency ultrasound sonophoresis in skin penetration of histamine: a randomized study in humans.
Topics: Administration, Cutaneous; Adult; Allergens; Drug Delivery Systems; Equipment Design; Female; Histam | 2010 |
Induction of nocebo and placebo effects on itch and pain by verbal suggestions.
Topics: Adolescent; Analysis of Variance; Double-Blind Method; Female; Histamine; Histamine Agonists; Humans | 2011 |
Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens.
Topics: Acetylcholine; Adult; Bradykinin; Capsaicin; Dinoprostone; Electric Stimulation; Female; Histamine; | 2003 |
Interaction between histamine-induced itch and experimental muscle pain.
Topics: Adult; Afferent Pathways; Capsaicin; Central Nervous System; Female; Histamine; Humans; Male; Models | 2004 |
Electrically evoked itch in humans.
Topics: Adult; Dermatitis, Atopic; Dose-Response Relationship, Radiation; Electric Stimulation; Erythema; Fe | 2005 |
A-3665, a new short-acting opioid: a comparison with alfentanil.
Topics: Adolescent; Adult; Alfentanil; Analgesics; Carbon Dioxide; Cardiovascular System; Dose-Response Rela | 1993 |
Comparative nasal effects of bradykinin and histamine: influence on nasal airways resistance and plasma protein exudation.
Topics: Administration, Inhalation; Adult; Airway Resistance; Blood Proteins; Bradykinin; Dose-Response Rela | 1993 |
High-potency topical corticosteroid rapidly decreases histamine-induced itch but not thermal sensation and pain in human beings.
Topics: Administration, Cutaneous; Adult; Analysis of Variance; Anti-Inflammatory Agents; Clobetasol; Double | 1996 |
A comparison of the effects of noxious and innocuous counterstimuli on experimentally induced itch and pain.
Topics: Adult; Female; Histamine; Hot Temperature; Humans; Male; Mustard Plant; Pain; Physical Stimulation; | 1996 |
Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia.
Topics: Adult; Analysis of Variance; Anesthetics, Local; Double-Blind Method; Forearm; Histamine; Humans; Hy | 1999 |
Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia.
Topics: Adult; Capsaicin; Forearm; Histamine; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Ag | 1999 |
Solvent for etomidate may cause pain and adverse effects.
Topics: Adult; Anesthetics, Intravenous; Chemistry, Pharmaceutical; Double-Blind Method; Etomidate; Fat Emul | 1999 |
Nociceptor activation and protein extravasation induced by inflammatory mediators in human skin.
Topics: Adult; Axons; Blood Proteins; Bradykinin; Erythema; Female; Free Radical Scavengers; Histamine; Huma | 2001 |
Experimental itch in sodium lauryl sulphate-inflamed and normal skin in humans: a randomized, double-blind, placebo-controlled study of histamine and other inducers of itch.
Topics: Adult; Dermatitis, Contact; Double-Blind Method; Edema; Erythema; Female; Histamine; Humans; Injecti | 2002 |
Topically applied aspirin decreases histamine-induced wheal and flare reactions in normal and SLS-inflamed skin, but does not decrease itch. A randomized, double-blind and placebo-controlled human study.
Topics: Administration, Topical; Adult; Analysis of Variance; Aspirin; Dermatitis, Irritant; Double-Blind Me | 2002 |
Anticholinergics: do they work in peptic ulcer?
Topics: Acute Disease; Antacids; Clinical Trials as Topic; Drug Therapy, Combination; Gastric Juice; Gastric | 1975 |
Local anaesthetic creams and intradermal skin tests.
Topics: Anesthetics, Local; Drug Combinations; Histamine; Humans; Injections, Intradermal; Lidocaine; Lidoca | 1992 |
A quantitative comparison of the effect of local analgesics on argon laser induced cutaneous pain and on histamine induced wheal, flare and itch.
Topics: Administration, Topical; Adult; Anesthetics, Local; Drug Combinations; Emollients; Female; Histamine | 1990 |
The effect of hypnotically induced analgesia on flare reaction of the cutaneous histamine prick test.
Topics: Adult; Analgesia; Double-Blind Method; Electroencephalography; Female; Histamine; Humans; Hypersensi | 1990 |
Effect of antihistamines on argon laser-induced cutaneous sensory and pain thresholds and on histamine-induced wheal and flare.
Topics: Adult; Analgesics; Histamine; Histamine Antagonists; Humans; Lasers; Pain; Photic Stimulation; Senso | 1989 |
Prostaglandins, aspirin-like drugs and analgesia.
Topics: Acetylcholine; Analgesia; Arachidonic Acids; Aspirin; Bradykinin; Clinical Trials as Topic; Erythema | 1972 |
193 other studies available for histamine and Pain
| Article | Year |
|---|---|
Clinical and histological characterization of transient dermal pain triggered by sweating stimuli.
Topics: Histamine; Humans; Hypohidrosis; Male; Pain; Retrospective Studies; Sweating; Urticaria | 2022 |
Punctate Administration of Ficin as a human and animal model of non-histaminergic itch.
Topics: Animals; Disease Models, Animal; Ficain; Histamine; Humans; Mice; Pain; Pruritus | 2022 |
Topical Capsaicin in Poly(lactic-co-glycolic)acid (PLGA) Nanoparticles Decreases Acute Itch and Heat Pain.
Topics: Animals; beta-Alanine; Capsaicin; Glycols; Histamine; Hot Temperature; Humans; Mice; Nanoparticles; | 2022 |
Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar
Topics: Animals; Histamine; Humans; Lepidoptera; Manduca; Nerve Tissue Proteins; Pain; Pruritus; Receptors, | 2022 |
Evaluation of anti-inflammatory and analgesic effects of Hertia intermedia (Boiss.) Kuntze extract.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Asteraceae; Carrageenan; Edema | 2022 |
Histamine H1 receptor antagonist attenuates catecholamine surge and organ injury after severe burns.
Topics: Animals; Cetirizine; Fentanyl; Histamine; Histamine H1 Antagonists; Midazolam; Pain; Promethazine; R | 2023 |
Histamine and its H 1 receptors in the ventral pallidum mediate formalin-induced pain-related behaviors through this region and spinal cord opioid receptors.
Topics: Animals; Basal Forebrain; Formaldehyde; Histamine; Histamine Agonists; Naloxone; Pain; Receptors, Op | 2023 |
Cowhage-induced itch scores and the current perception threshold in assessing sensitive skin: An observational laboratory study.
Topics: Histamine; Humans; Pain; Perception; Pruritus; Sensation; Skin | 2023 |
Microglia are involved in regulating histamine-dependent and non-dependent itch transmissions with distinguished signal pathways.
Topics: Animals; Chloroquine; Histamine; Mice; Mice, Transgenic; Microglia; Pain; Pruritus; Signal Transduct | 2023 |
Crisaborole Inhibits Itch and Pain by Preventing Neutrophil Infiltration in a Mouse Model of Atopic Dermatitis.
Topics: Animals; Calcium; Capsaicin; Chloroquine; Dermatitis, Atopic; Disease Models, Animal; Histamine; Neu | 2023 |
Calcium imaging of primary canine sensory neurons: Small-diameter neurons responsive to pruritogens and algogens.
Topics: Animals; Cadaver; Calcium Radioisotopes; Capsaicin; Cattle; Cells, Cultured; Chloroquine; Dogs; Gang | 2019 |
Hippocalcin-like 4, a neural calcium sensor, has a limited contribution to pain and itch processing.
Topics: Animals; Behavior Rating Scale; Behavior, Animal; Chloroquine; Gene Knockout Techniques; Histamine; | 2020 |
Exploration of sensory and spinal neurons expressing gastrin-releasing peptide in itch and pain related behaviors.
Topics: Animals; Disease Models, Animal; Gastrin-Releasing Peptide; Gene Knockout Techniques; Histamine; Mic | 2020 |
Early radiation-induced oral pain signaling responses are reduced with pentoxifylline treatment.
Topics: Animals; Capsaicin; Histamine; Mice; Pain; Pentoxifylline; Pilot Projects; Prospective Studies; Radi | 2021 |
The role of pruriceptors in enhancing sensitivity to pruritogens in a murine chronic compression model of dorsal root ganglion.
Topics: Animals; Calcium; Capsaicin; Cattle; Chronic Disease; Disease Models, Animal; Ganglia, Spinal; Hista | 2021 |
Pharmacological studies on aqueous extract of Launaea arborescens from southwest Algeria.
Topics: Algeria; Analgesics; Animals; Anti-Inflammatory Agents; Asteraceae; Behavior, Animal; Capsaicin; Ede | 2021 |
Sulfonamides as Selective Na
Topics: Analgesics; Animals; Capsaicin; Cell Line; Dogs; Histamine; Mice, Inbred C57BL; Molecular Docking Si | 2017 |
UVB- and NGF-induced cutaneous sensitization in humans selectively augments cowhage- and histamine-induced pain and evokes mechanical hyperknesis.
Topics: Adult; Female; Histamine; Humans; Hyperalgesia; Male; Mucuna; Nerve Growth Factor; Nociception; Pain | 2018 |
Potamotrygon motoro stingray venom induces both neurogenic and inflammatory pain behavior in rodents.
Topics: Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Fish Venoms; Histamine; Hyperalgesia; In | 2018 |
Responses of thalamic neurons to itch- and pain-producing stimuli in rats.
Topics: Action Potentials; Animals; Antipruritics; beta-Alanine; Capsaicin; Chloroquine; Histamine; Injectio | 2018 |
Enhanced histamine-induced itch in diacylglycerol kinase iota knockout mice.
Topics: Animals; Behavior, Animal; Calcium; Diacylglycerol Kinase; Disease Models, Animal; Female; Ganglia, | 2019 |
Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons.
Topics: Action Potentials; Analgesics, Opioid; Animals; Antirheumatic Agents; Chloroquine; Electric Stimulat | 2013 |
Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1.
Topics: Animals; Capsaicin; Chloroquine; Constriction; Disease Models, Animal; Functional Laterality; Histam | 2013 |
Histamine produces opposing effects to serotonin in the knee joint of rats.
Topics: Analysis of Variance; Animals; Cetirizine; Edema; Evans Blue; Formaldehyde; Histamine; Histamine H1 | 2013 |
Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons.
Topics: Action Potentials; Anesthetics, Local; Animals; Antipruritics; Antirheumatic Agents; Behavior, Anima | 2013 |
Sensitivity to itch and pain in patients with psoriasis and rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cold Temperature; Female; Histamine; Humans; Inflammation; Middl | 2013 |
Polysaccharide isolated from Agardhiella ramosissima: chemical structure and anti-inflammation activity.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cell Movement; Dextrans; Edema; Galactose; Hindlimb; | 2014 |
Anti-inflammatory and antinociceptive effects of Sterculia striata A. St.-Hil. & Naudin (Malvaceae) in rodents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Carrageenan; Dextrans; Edema; | 2014 |
Behavioral model of itch, alloknesis, pain and allodynia in the lower hindlimb and correlative responses of lumbar dorsal horn neurons in the mouse.
Topics: Action Potentials; Animals; Capsaicin; Disease Models, Animal; Electrophysiology; Hindlimb; Histamin | 2014 |
Peripheral antinociception and anti-inflammatory effects of sulphated polysaccharides from the alga Caulerpa mexicana.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Caulerpa; Dextrans; Disease Models, Anim | 2014 |
Hemokinin-1 mediates pruriceptive processing in the rat spinal cord.
Topics: Animals; Disease Models, Animal; Formaldehyde; Histamine; Immunohistochemistry; Male; Nociception; P | 2014 |
Mechano-sensitive nociceptors are required to detect heat pain thresholds and cowhage itch in human skin.
Topics: Adult; Histamine; Hot Temperature; Humans; Iontophoresis; Male; Mechanoreceptors; Nociceptors; Pain; | 2016 |
Effects of microinjection of histamine into the anterior cingulate cortex on pain-related behaviors induced by formalin in rats.
Topics: Animals; Formaldehyde; Gyrus Cinguli; Histamine; Male; Microinjections; Pain; Pain Measurement; Rats | 2015 |
[Vulvar oedema revealing systemic mastocytosis].
Topics: Adult; Biomarkers; Bone Diseases; Diarrhea; Edema; Female; Histamine; Humans; Immunosuppressive Agen | 2015 |
The Maddening Sensation of Itch.
Topics: Animals; Histamine; Histamine Antagonists; Humans; Neurons; Pain; Peptide Hydrolases; Pruritus; Rece | 2016 |
Phytochemical screening, safety evaluation, anti-inflammatory and analgesic studies of the leaf extracts of Sterculia tragacantha.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Female; Flavonoi | 2016 |
Conditioning pain stimulation does not affect itch induced by intra-epidermal histamine pricks but aggravates neurogenic inflammation in healthy volunteers.
Topics: Adult; Female; Galvanic Skin Response; Healthy Volunteers; Heart Rate; Histamine; Histamine Agonists | 2016 |
Analgesic and anti-inflammatory actions on bradykinin route of a polysulfated fraction from alga Ulva lactuca.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Bradykinin; Carrageenan; Chemical Fracti | 2016 |
TRPA1, substance P, histamine and 5-hydroxytryptamine interact in an interdependent way to induce nociception.
Topics: Acetanilides; Animals; Histamine; Histamine H1 Antagonists; Isothiocyanates; Male; Oligonucleotides, | 2017 |
A novel zebrafish-based model of nociception.
Topics: Acetic Acid; Acrolein; Analgesics, Opioid; Animals; Antineoplastic Agents, Phytogenic; Disease Model | 2017 |
Separate peripheral pathways for pruritus in man.
Topics: Capsaicin; Electric Stimulation; Electrophysiology; Histamine; Hot Temperature; Humans; Mechanorecep | 2008 |
Residual spinothalamic tract pathways predict development of central pain after spinal cord injury.
Topics: Adult; Capsaicin; Cold Temperature; Female; Histamine; Hot Temperature; Humans; Male; Menthol; Middl | 2008 |
Behavioral differentiation between itch and pain in mouse.
Topics: Animals; Behavior, Animal; Capsaicin; Cheek; Dose-Response Relationship, Drug; Forelimb; Hindlimb; H | 2008 |
TRPA1-mediated nociception.
Topics: Animals; Formaldehyde; Histamine; Mice; Nociceptors; Pain; Transient Receptor Potential Channels; TR | 2008 |
Cellular basis of itch sensation.
Topics: Afferent Pathways; Animals; Behavior, Animal; Bombesin; Chronic Disease; Histamine; Humans; Male; Mi | 2009 |
Possible involvement of histamine, dopamine, and noradrenalin in the periaqueductal gray in electroacupuncture pain relief.
Topics: Animals; Dopamine; Electroacupuncture; Formaldehyde; Histamine; Male; Microdialysis; Neurons; Neurot | 2010 |
Histamine potentiates acid-induced responses mediating transient receptor potential V1 in mouse primary sensory neurons.
Topics: Acids; Action Potentials; Animals; Calcium Signaling; Enzyme Inhibitors; Ganglia, Spinal; Histamine; | 2010 |
Cryotherapy decreases histamine levels in the blood of patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; beta-N-Acetylhexosaminidases; Cartilage; Cryotherapy; Enzyme-Linked Immunosor | 2010 |
Role of attentional focus on bodily sensations in sensitivity to itch and pain.
Topics: Administration, Topical; Adult; Attention; Capsaicin; Cold Temperature; Electric Stimulation; Female | 2010 |
Inhibition of brain [(3)H]cimetidine binding by improgan-like antinociceptive drugs.
Topics: Analgesics; Animals; Binding Sites; Brain; Cimetidine; Dose-Response Relationship, Drug; Histamine; | 2010 |
Heterotopic pruritic conditioning and itch--analogous to DNIC in pain?
Topics: Adult; Aged; Central Nervous System; Chronic Disease; Conditioning, Psychological; Electric Stimulat | 2010 |
[Acupoint-injection of histamine induced analgesic effect in acute adjuvant-induced-arthritis rats].
Topics: Acupuncture Points; Acute Disease; Analgesics; Animals; Arthritis; Disease Models, Animal; Freund's | 2010 |
VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch.
Topics: Animals; Behavior, Animal; Female; Histamine; Humans; Immunohistochemistry; In Situ Hybridization; M | 2010 |
Differential itch- and pain-related behavioral responses and µ-opoid modulation in mice.
Topics: Analgesics, Opioid; Animals; Antigens, Plant; Behavior, Animal; Capsaicin; Disease Models, Animal; D | 2010 |
Involvement of glial cells in the nociceptive behaviors induced by a high-dose of histamine administered intrathecally.
Topics: Agmatine; Animals; Behavior, Animal; Blotting, Western; Dizocilpine Maleate; Dose-Response Relations | 2011 |
Partial involvement of NMDA receptors and glial cells in the nociceptive behaviors induced by intrathecally administered histamine.
Topics: Animals; Histamine; Injections, Spinal; Male; Mice; Neuroglia; Neurotransmitter Agents; Pain; Pain P | 2011 |
Role of TRPV1 in nociception and edema induced by monosodium urate crystals in rats.
Topics: Acrylamides; Anilides; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Antioxidants; Bridged B | 2011 |
Interaction of histamine and calcitonin gene-related peptide in the formalin induced pain perception in rats.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antag | 2011 |
Protective role of the triterpenoid-enriched extract of Trichosanthes dioica root against experimentally induced pain and inflammation in rodents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dose-Response Relationship, | 2012 |
A report on anti-oedemogenic activity of Byttneria herbacea roots--possible involvement of histamine receptor (type I).
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Capillary Permeability; Carrageenan; Dose-Respon | 2012 |
Role of induced negative and positive emotions in sensitivity to itch and pain in women.
Topics: Analysis of Variance; Cold Temperature; Electric Stimulation; Emotions; Female; Histamine; Histamine | 2012 |
Endothelin-1 induces itch and pain in the mouse cheek model.
Topics: Animals; Behavior, Animal; Capsaicin; Cheek; Dose-Response Relationship, Drug; Endothelin A Receptor | 2012 |
Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant.
Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Behavior, A | 2012 |
CGRPα-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch.
Topics: Animals; Brain; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Chloroquine; Female; Ga | 2012 |
Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dantrolene; | 2002 |
Combined action of vasoactive amines and bradykinin mediates allergen-evoked thermal hyperalgesia in rats.
Topics: Allergens; Animals; Bradykinin; Bradykinin Receptor Antagonists; Cyproheptadine; Dinitrophenols; Dos | 2003 |
Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Dextromethorphan; Dose-Response | 2003 |
Anti-inflammatory and analgesic activity of Bouchea fluminensis.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dose- | 2003 |
Mechanism of anti-nociceptive effects of Asarum sieboldii Miq. radix: potential role of bradykinin, histamine and opioid receptor-mediated pathways.
Topics: Analgesics, Non-Narcotic; Animals; Asarum; Bradykinin; Carrageenan; Edema; Guinea Pigs; Histamine; I | 2003 |
Analgesic and antiinflammatory activity of antibodies to histamine under experimental conditions.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antibodies; Histamine; Mice; Pain; Rats | 2003 |
[Thermoanalgesic properties of cortisone and ACTH; modification of pain reaction by histamine bichlorhydrate, cooling and formol].
Topics: Adrenocorticotropic Hormone; Body Temperature; Cold Temperature; Cortisone; Formaldehyde; Histamine; | 1952 |
Chemical excitants of cutaneous pain in man.
Topics: Acetylcholine; Histamine; Histamine Agents; Musculoskeletal Diseases; Pain | 1953 |
[Phenomenon of pain reactivation following cutaneous and muscular introduction of histamine].
Topics: Administration, Cutaneous; Histamine; Humans; Muscles; Pain | 1953 |
[Effect of histamine on pain threshold of the skin].
Topics: Histamine; Histamine Agents; Humans; Pain; Pain Threshold; Skin | 1953 |
The influence of acetylcholine, curarine and related substance on the threshold for chemical pain stimuli.
Topics: Acetylcholine; Curare; Histamine; Histamine Agents; Humans; Muscle Relaxants, Central; Pain; Potassi | 1953 |
Pharyngeal and laryngeal phenomena of vascular origin.
Topics: Histamine; Humans; Laryngeal Diseases; Larynx; Pain; Pharynx | 1953 |
The effect of histamine analogues on cutaneous pain.
Topics: Histamine; Humans; Inorganic Chemicals; Musculoskeletal Diseases; Pain | 1953 |
On the mechanism of ulcer pain.
Topics: Histamine; Histamine Agents; Pain; Peptic Ulcer; Ulcer | 1954 |
[Effect of pain stimulus on histamine in blood].
Topics: Blood; Histamine; Humans; Pain | 1955 |
[Effect of pain stimulus on blood histamine].
Topics: Biological Phenomena; Blood; Histamine; Humans; Pain; Physiological Phenomena | 1955 |
[Physiology and clinical aspects of the pain sensation].
Topics: Histamine; Humans; Pain; Skin Physiological Phenomena | 1956 |
[Role of histamine in the transmission of pain].
Topics: Histamine; Humans; Pain | 1956 |
[Transmission of pain sensitivity in human skin].
Topics: Histamine; Humans; Pain; Pain Threshold; Skin; Skin Physiological Phenomena | 1957 |
[Significance of histamine in reflex reactions of the organism in multiple pain stimulation].
Topics: Heart; Histamine; Histamine Agents; Nervous System Physiological Phenomena; Pain; Reflex | 1957 |
Histamine release and pain production by xanthosine and related compounds.
Topics: Adenosine; Animals; Cats; Female; Guanosine; Guinea Pigs; Histamine; Histamine Release; Humans; Ileu | 1957 |
[Treatment of various diseases and alleviation of pain by bettering the circulation with intracutaneous medication].
Topics: Biological Phenomena; Blood Circulation; Blood Proteins; Heparin; Histamine; Humans; Injections, Int | 1958 |
Effect of chlorpromazine on antidiuretic response to noxious stimuli.
Topics: Chlorpromazine; Diuresis; Histamine; Histamine Agents; Nicotine; Pain | 1958 |
[Inflammation & pain in histamine-free skin].
Topics: Histamine; Inflammation; Pain; Skin | 1958 |
[CONTRIBUTION TO THE QUESTION OF PAIN OR HYPERALGESIA RELEASING SUBSTANCES].
Topics: Anti-Allergic Agents; Contusions; Histamine; Histamine H1 Antagonists; Histamine Release; Humans; Hy | 1963 |
NOCICEPTIVE RESPONSES OF GUINEA-PIGS TO INTRADERMAL INJECTIONS OF BRADYKININ AND KALLIDIN-10.
Topics: Acetylcholine; Animals; Bradykinin; Guinea Pigs; Histamine; Humans; Injections, Intradermal; Injecti | 1963 |
[PHARMACODYNAMIC TESTS IN THE DIAGNOSIS OF ULCEROUS DISEASE. I. VALUE OF SOME DIAGNOSTIC TESTS TO INDUCE ULCEROUS PAINS BY MOTOR AND SECRETORY FUNCTIONAL OVERLOAD].
Topics: Biological Transport; Diagnosis; Diagnostic Tests, Routine; Histamine; Hydrochloric Acid; Insulin; P | 1963 |
[SOME PROBLEMS CONCERNING THE PRE-ULCEROUS PHASE OF ULCEROUS DISEASE].
Topics: Diagnosis; Dyspepsia; Gastric Acidity Determination; Gastrointestinal Hemorrhage; Hemorrhage; Histam | 1963 |
[A COMMENTARY ON ARTHRALGIA].
Topics: Acetylcholine; Arthralgia; Arthritis; Autonomic Nervous System; Histamine; Humans; Joint Diseases; N | 1963 |
Observations on histamine-induced pruritus and pain.
Topics: Histamine; Pain; Pruritus | 1955 |
[Analysis of the behavior of cutaneous pain following the intradermal injection of histamine, acetylcholine, adrenaline and 5-hydroxytryptamine].
Topics: Acetylcholine; Epinephrine; Histamine; Humans; Injections, Intradermal; Musculoskeletal Diseases; Pa | 1960 |
Painful stimuli evoke itch in patients with chronic pruritus: central sensitization for itch.
Topics: Adult; Dermatitis, Atopic; Electric Stimulation; Female; Histamine; Hot Temperature; Humans; Male; M | 2004 |
Intra-arterial histamine in treatment of claudication and rest pain.
Topics: Arteriosclerosis; Histamine; Humans; Intermittent Claudication; Pain | 1950 |
Responses of the abnormal arterial circulation to various stimuli, as studied by the use of radioactive sodium. II. Intraarterial histamine, papaverine, aminophylline and adrenaline; sympathectomy and etamon; pain.
Topics: Aminophylline; Arteries; Blood Vessels; Epinephrine; Histamine; Humans; Pain; Papaverine; Sodium; So | 1951 |
[On the effect of histamin and antihistamin on Head's zone; a contribution on pathophysiology of referred pain and of the functional shifts].
Topics: Anti-Allergic Agents; Head; Histamine; Histamine Agents; Histamine H1 Antagonists; Humans; Pain; Pai | 1952 |
Histamine as possible chemical mediator for cutaneous pain; painful responses on intradermal injection of perfusates from stimulated human skin.
Topics: Histamine; Humans; Injections, Intradermal; Musculoskeletal Diseases; Pain; Pain Management | 1949 |
Histamine as possible chemical mediator for cutaneous pain. Dual pain response to histamine.
Topics: Histamine; Humans; Musculoskeletal Diseases; Pain; Skin | 1950 |
[Action of phenergan syrup on gastric pains].
Topics: Abdominal Pain; Histamine; Humans; Pain; Promethazine; Stomach | 1950 |
Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: a study in histidine decarboxylase gene knockout mice.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Behavior, Animal; Capsaicin; Excitatory Amino Acid | 2005 |
Noxious heat and scratching decrease histamine-induced itch and skin blood flow.
Topics: Cold Temperature; Dermatitis, Atopic; Female; Histamine; Hot Temperature; Humans; Male; Pain; Region | 2005 |
Bradykinin is a potent pruritogen in atopic dermatitis: a switch from pain to itch.
Topics: Adult; Bradykinin; Cross-Over Studies; Dermatitis, Atopic; Female; Histamine; Histamine H1 Antagonis | 2006 |
Antinociceptive and anti-inflammatory effects of Thespesia populnea bark extract.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; | 2007 |
Anti-inflammatory and antinociceptive activities of extract, fractions and populnoic acid from bark wood of Austroplenckia populnea.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Brazil; Capillary Permeability; Carrageenan; Celastra | 2007 |
[Effect of nociceptin on histamine and serotonin release in the central nervous system].
Topics: Animals; Disease Models, Animal; Hippocampus; Histamine; Histamine Release; Hypothalamus; Pain; Rats | 2006 |
Neural correlates of perceptual difference between itching and pain: a human fMRI study.
Topics: Adult; Cold Temperature; Data Interpretation, Statistical; Gyrus Cinguli; Histamine; Humans; Image P | 2007 |
Indirect mechanism of histamine-induced nociception in temporomandibular joint of rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Dose-Response Relationship, Drug | 2007 |
Itch induced by a novel method leads to limbic deactivations a functional MRI study.
Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Brain; Codeine; Data Interpretation, Statistical; Fem | 2007 |
Role of histaminergic neurons in hypnotic modulation of brain processing of visceral perception.
Topics: Adult; Brain; Chlorpheniramine; Electric Stimulation; Electroencephalography; Evoked Potentials, Som | 2007 |
Heritability of responses to painful stimuli in women: a classical twin study.
Topics: Acids; Adenosine Triphosphate; Adult; Aged; Burns; Burns, Chemical; Female; Histamine; Hot Temperatu | 2007 |
Repetitive scratching and noxious heat do not inhibit histamine-induced itch in atopic dermatitis.
Topics: Adult; Dermatitis, Atopic; Female; Histamine; Hot Temperature; Humans; Iontophoresis; Male; Middle A | 2008 |
Intrathecal high-dose histamine induces spinally-mediated nociceptive behavioral responses through a polyamine site of NMDA receptors.
Topics: Animals; Excitatory Amino Acid Antagonists; Histamine; Injections, Spinal; Male; Mice; Mice, Inbred | 2008 |
Anti-inflammatory and anti-nociceptive activities of Fumaria indica whole plant extract in experimental animals.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cotto | 2007 |
Mast cell-derived histamine mediates cystitis pain.
Topics: Animals; Cystitis; Herpesvirus 1, Suid; Histamine; Mast Cells; Mice; Pain; Pelvis; Pseudorabies; Rec | 2008 |
The chemistry of pain production.
Topics: Acetylcholine; Bradykinin; Histamine; Humans; Migraine Disorders; Pain; Potassium; Serotonin; Urtica | 1967 |
Anti-inflammatory evaluation of cryogenine.
Topics: Analgesics; Animals; Bradykinin; Carrageenan; Drinking; Drug Antagonism; Edema; Female; Fever; Guine | 1967 |
Responses of skin blood vessels to bradykinin, histamine and 5-hydroxytryptamine.
Topics: Adult; Arteries; Blood Vessels; Bradykinin; Chlorpheniramine; Female; Histamine; Humans; Hydrocortis | 1967 |
On the etiopathogenesis of migraine: a possible link between the amines and endorphin hypotheses.
Topics: Adult; Clonidine; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Histamine; Huma | 1982 |
Dependence of histamine-evoked nociception on prostaglandin release.
Topics: Animals; Drug Interactions; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Indometha | 1981 |
[Reactivation of the algogenic component in experimental inflammation induced by histamine administration].
Topics: Dermatitis, Contact; Dry Ice; Histamine; Histamine Release; Humans; Injections, Intravenous; Pain | 1983 |
Intrinsic mechanisms of pain inhibition: activation by stress.
Topics: Adaptation, Physiological; Adrenalectomy; Anesthesia; Animals; Brain Stem; Conditioning, Psychologic | 1984 |
C nociceptor activity in human nerve during painful and non painful skin stimulation.
Topics: Adult; Histamine; Hot Temperature; Humans; Methylene Chloride; Nerve Fibers; Neural Conduction; Noci | 1981 |
Scratching behavior induced by pruritogenic but not algesiogenic agents in mice.
Topics: Animals; Behavior, Animal; Capsaicin; Formaldehyde; Histamine; Male; Mice; p-Methoxy-N-methylpheneth | 1995 |
Effects of topical capsaicin in seasonal allergic rhinitis.
Topics: Administration, Topical; Adult; Allergens; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid | 1995 |
Importance of histamine H2 receptors in restraint-morphine interactions.
Topics: Analysis of Variance; Animals; Benzothiazoles; Histamine; Histamine H2 Antagonists; Male; Morphine; | 1995 |
Small fibre function in primary autonomic failure.
Topics: Afferent Pathways; Autonomic Nervous System; Axons; Female; Histamine; Humans; Hypotension, Orthosta | 1993 |
Postherpetic neuralgia. Are C-nociceptors involved in signalling and maintenance of tactile allodynia?
Topics: Aged; Body Temperature; Female; Herpes Zoster; Histamine; Humans; Iontophoresis; Male; Middle Aged; | 1993 |
The ability of humans to localise noxious stimuli.
Topics: Adult; Brain Mapping; Female; Histamine; Hot Temperature; Humans; Male; Middle Aged; Mustard Plant; | 1993 |
Conditioning of histamine by bradykinin alters responses of rat nociceptor and human itch sensation.
Topics: Adult; Animals; Bradykinin; Female; Histamine; Humans; Iontophoresis; Male; Middle Aged; Models, Bio | 1993 |
Effect of topically applied menthol on thermal, pain and itch sensations and biophysical properties of the skin.
Topics: Administration, Topical; Adult; Biophysical Phenomena; Biophysics; Female; Histamine; Hot Temperatur | 1996 |
Investigation into the role of histamine receptors in rodent antinociception.
Topics: Animals; Burimamide; Dose-Response Relationship, Drug; Histamine; Impromidine; Male; Mice; Mice, Inb | 1996 |
Asymmetry and time-course of cutaneous sympathetic reflex responses following sustained excitation of chemosensitive nociceptors in humans.
Topics: Adult; Afferent Pathways; Female; Histamine; Humans; Male; Middle Aged; Mustard Plant; Pain; Pain Me | 1996 |
Central serotonergic and histaminergic modulation of peripheral inflammation and nociception in rats.
Topics: Animals; Foot; Formaldehyde; Histamine; Histamine Agonists; Histamine Antagonists; Inflammation; Inj | 1996 |
Plasma extravasation and neuropeptide release in human skin as measured by intradermal microdialysis.
Topics: Adult; Axons; Calcitonin Gene-Related Peptide; Capsaicin; Forearm; Histamine; Humans; Inflammation; | 1997 |
Effects of cutaneous histamine application in patients with sympathetic reflex dystrophy.
Topics: Adult; Axons; Female; Histamine; Humans; Iontophoresis; Male; Middle Aged; Pain; Reference Values; R | 1997 |
Antinociceptive activity of impentamine, a histamine congener, after CNS administration.
Topics: Analgesics; Animals; Cerebral Ventricles; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; | 1999 |
Capsaicin sensitivity and voltage-gated sodium currents in colon sensory neurons from rat dorsal root ganglia.
Topics: Action Potentials; Adenosine; Analgesics; Animals; Bradykinin; Capsaicin; Carbocyanines; Colon; Dino | 1999 |
Activation of spinal wide dynamic range neurons by intracutaneous microinjection of nicotine.
Topics: Action Potentials; Animals; Azetidines; Histamine; Histamine H1 Antagonists; Hot Temperature; Male; | 1999 |
In vivo signal transduction of nociceptive response by kyotorphin (tyrosine-arginine) through Galpha(i)- and inositol trisphosphate-mediated Ca(2+) influx.
Topics: Analgesics; Animals; Calcium; Calcium Channels; Endorphins; GTP-Binding Protein alpha Subunits, Gi-G | 2000 |
Opposite modulation of histaminergic neurons by nociceptin and morphine.
Topics: Analgesics, Opioid; Animals; Histamine; Hypothalamus; Male; Mammillary Bodies; Membrane Potentials; | 2000 |
Does the histaminergic system play a role in spinal nociception?
Topics: Animals; Dose-Response Relationship, Drug; Histamine; Histamine Agonists; Histamine Antagonists; In | 2000 |
Inhibitory effects of cimicifugae rhizoma extracts on histamine, bradykinin and COX-2 mediated inflammatory actions.
Topics: Animals; Bradykinin; Dinoprost; Enzyme-Linked Immunosorbent Assay; Guinea Pigs; Histamine; Ileum; In | 2000 |
The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception.
Topics: Animals; Anti-Asthmatic Agents; Cimetidine; Cromolyn Sodium; Histamine; Histamine H1 Antagonists; Hi | 2001 |
Chronic low-level administration of diquat increases the nociceptive response to gastric distension in rats: role of mast cells and tachykinin receptor activation.
Topics: Animals; Blood Pressure; Bronchodilator Agents; Diquat; Food Contamination; Gastric Dilatation; Herb | 2001 |
Central activation by histamine-induced itch: analogies to pain processing: a correlational analysis of O-15 H2O positron emission tomography studies.
Topics: Adult; Cerebral Cortex; Cerebrovascular Circulation; Histamine; Humans; Male; Oxygen Radioisotopes; | 2001 |
Histamine H1 receptor mRNA is expressed in capsaicin-insensitive sensory neurons with neuropeptide Y-immunoreactivity in guinea pigs.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Ganglia, Spinal; Guinea Pigs; Histamine; Immuno | 2001 |
Histamine-induced itch converts into pain in neuropathic hyperalgesia.
Topics: Histamine; Hot Temperature; Humans; Hyperalgesia; Nociceptors; Pain; Pruritus | 2001 |
ReN 1869, a novel tricyclic antihistamine, is active against neurogenic pain and inflammation.
Topics: Animals; Benzoquinones; Binding Sites; Calcitonin Gene-Related Peptide; Calcium; Calcium Channels; C | 2002 |
Responses of superficial dorsal horn neurons to intradermal serotonin and other irritants: comparison with scratching behavior.
Topics: Animals; Behavior, Animal; Capsaicin; Disinfectants; Electrophysiology; Formaldehyde; Histamine; Inj | 2002 |
ATP responses in human C nociceptors.
Topics: Adenosine Triphosphate; Adult; Dose-Response Relationship, Drug; Female; Histamine; Hot Temperature; | 2002 |
Biochemical basis of analgesia: metabolism, storage, regulation, and action.
Topics: Analgesia; Bradykinin; Dopamine; Enkephalins; Glutamates; Histamine; Neurotransmitter Agents; Norepi | 1978 |
Management of benign disease of the breast.
Topics: Breast; Breast Diseases; Breast Neoplasms; Cysts; Female; Histamine; Histamine H1 Antagonists; Hormo | 1978 |
Nervous outflow from skeletal muscle following chemical noxious stimulation.
Topics: Animals; Bradykinin; Cats; Histamine; Muscle Spindles; Muscles; Nerve Fibers, Myelinated; Neurons, A | 1977 |
Inflammation and the role of endogenous pain-producing substances.
Topics: Acetaminophen; Anti-Inflammatory Agents; Bradykinin; Histamine; Humans; Inflammation; Kallikreins; K | 1978 |
Activation of afferent cardiac sympathetic nerve fibers of the cat by pain producing substances and by noxious heat.
Topics: Acetylcholine; Action Potentials; Animals; Bradykinin; Cats; Chemoreceptor Cells; Female; Heart; His | 1977 |
Comparative analgetic testing of various compounds in mice using writhing techniques.
Topics: Acetylcholine; Analgesics; Animals; Bradykinin; Histamine; Lethal Dose 50; Male; Mice; Pain; Quinone | 1978 |
Action of U.V. rays on the the experimental cutaneous inflammation induced by cantharidin.
Topics: Cantharidin; Dermatitis, Contact; Histamine; Humans; Inflammation; Pain; Radiation Effects; Time Fac | 1976 |
Evidence for the existence of different receptor sites for algesic agents at the endings of muscular group IV afferent units.
Topics: Animals; Bradykinin; Cats; Electrophysiology; Histamine; Injections, Intra-Arterial; Injections, Int | 1976 |
The effect of thiazol-4-yimethoxyamine, a histidine decarboxylase inhibitor, on the development of morphine tolerance and physical dependance in mice.
Topics: Animals; Behavior, Animal; Brain; Carboxy-Lyases; Drug Tolerance; Female; Histamine; Histidine Decar | 1976 |
Chemosensitive spinal afferents: thresholds of specific and nociceptive reflexes as compared with thresholds of excitation for receptors and axons.
Topics: Acetylcholine; Animals; Blood Pressure; Bradykinin; Carbachol; Cats; Chemoreceptor Cells; Histamine; | 1976 |
Electrophysiological correlates for antinociceptive effects of histamine after intracerebral administration to the rat.
Topics: Analgesics; Animals; Arthritis, Experimental; Brain; Electrophysiology; Evoked Potentials; Histamine | 1992 |
Vasodilator flare due to activation of superficial cutaneous afferents in humans: heat-sensitive versus histamine-sensitive fibers.
Topics: Histamine; Hot Temperature; Humans; Microcirculation; Nerve Fibers; Neurons, Afferent; Pain; Pruritu | 1992 |
Neuropathic pain behavior in rats depends on the afferent input from nerve-end neuroma including histamine-sensitive C-fibers.
Topics: Animals; Astemizole; Behavior, Animal; Histamine; Histamine H1 Antagonists; Male; Nerve Endings; Ner | 1991 |
[Role of pain component in the organization of chemosensory taste reaction].
Topics: Animals; Capsicum; Chemoreceptor Cells; Fluorescence; Histamine; Histamine Release; Histocytochemist | 1991 |
Discharge patterns of human C-fibers induced by itching and burning stimuli.
Topics: Adult; Electric Stimulation; Female; Histamine; Humans; Male; Middle Aged; Mustard Plant; Nerve Fibe | 1991 |
Involvement of histamine in naloxone-resistant and naloxone-sensitive models of swim stress-induced antinociception in the mouse.
Topics: Animals; Drug Tolerance; Histamine; Histamine Antagonists; Hot Temperature; Male; Mice; Mice, Inbred | 1991 |
[The role of humoral factors in the mechanism of the analgesic effect of electroacupuncture].
Topics: Animals; Dinoprost; Dogs; Electroacupuncture; Enkephalin, Leucine; Enkephalin, Methionine; Histamine | 1990 |
[Use of cimetidine with histamine in 4 patients with inoperable neoplasms of the upper part of the digestive tract].
Topics: Adenocarcinoma; Aged; Carcinoma; Cimetidine; Drug Therapy, Combination; Esophageal Neoplasms; Histam | 1985 |
On the nature of the afferent fibers of oculomotor nerve.
Topics: Animals; Bradykinin; Capsaicin; Histamine; Hot Temperature; Nociceptors; Oculomotor Nerve; Pain; She | 1989 |
A role for histamine and histamine H2-receptors in non-opiate footshock-induced analgesia.
Topics: Animals; Cimetidine; Electroshock; Haloperidol; Histamine; Histamine H2 Antagonists; Male; Naloxone; | 1985 |
Reflex excitation of masticatory muscles induced by algesic chemicals applied to the temporomandibular joint of the cat.
Topics: Animals; Cats; Histamine; Masticatory Muscles; Pain; Potassium Chloride; Reflex; Sodium Chloride; Te | 1988 |
Effects of temporomandibular joint stimulation on nociceptive and nonnociceptive neurons of the cat's trigeminal subnucleus caudalis (medullary dorsal horn).
Topics: Animals; Bradykinin; Cats; Electric Stimulation; Histamine; Neurons, Afferent; Nociceptors; Pain; Ph | 1988 |
Congenital familial sensory neuropathy with anhidrosis.
Topics: Child; Child, Preschool; Dysautonomia, Familial; Female; Histamine; Humans; Intellectual Disability; | 1966 |
A case of congenital indifference to pain (neurologic and psychiatric findings).
Topics: Adult; Electric Stimulation; Female; Galvanic Skin Response; Histamine; Humans; Pain; Pain Insensiti | 1968 |
Multiple (subcutaneous) angiolipomas. Clinical, pathologic, and pharmacologic studies.
Topics: Adenosine Triphosphatases; Adult; Alkaline Phosphatase; Blood Vessels; Cold Temperature; Hemangioma; | 1974 |
Action of peptides and other algesic agents on paravascular pain receptors of the isolated perfused rabbit ear.
Topics: Acetylcholine; Action Potentials; Adenosine; Adenosine Triphosphate; Angiotensin II; Animals; Blood | 1974 |
Antagonism by aspirin and fenamates of bronchoconstriction and nociception induced by adenosine-5'-triphosphate.
Topics: Acetylcholine; Adenine Nucleotides; Adenosine Triphosphate; Anaphylaxis; Animals; Anti-Inflammatory | 1966 |
Cortical potentials evoked by nociceptive stimuli: their depression by a factor released during saphenous nerve stimulation in the rat.
Topics: Adenosine Triphosphate; Animals; Aspirin; Bradykinin; Cerebral Cortex; Dental Pulp; Dose-Response Re | 1974 |
In vivo and in vitro evaluation of liquid antacids.
Topics: Aluminum Hydroxide; Antacids; Dose-Response Relationship, Drug; Duodenal Ulcer; Esophagitis, Peptic; | 1973 |
Pain problems of significance in the head and face, some of which often are misdiagnosed.
Topics: Adult; Brain Neoplasms; Cerebral Arteries; Diagnosis, Differential; Face; Facial Neuralgia; Female; | 1973 |
Influence of body posture on leg blood flow.
Topics: Arteries; Female; Histamine; Humans; Hypertension; Intermittent Claudication; Ischemia; Leg; Male; M | 1973 |
Activation of group IV afferent units from muscle by algesic agents.
Topics: Animals; Bradykinin; Cats; Histamine; Muscles; Neural Conduction; Neurons; Neurons, Afferent; Pain; | 1974 |
Histamine explanation of acupuncture.
Topics: Acupuncture Therapy; Capillaries; Epinephrine; Histamine; Humans; Pain | 1972 |
[Effect of adrenaline, acetylcholine and histamine on human sensations of pain].
Topics: Acetylcholine; Epinephrine; Histamine; Humans; Pain; Peripheral Nerves; Skin | 1971 |
[Pain producing substances].
Topics: Chemoreceptor Cells; Extracellular Space; Histamine; Humans; Kinins; Pain; Potassium; Serotonin | 1969 |
[Chemical mediators of pain].
Topics: Acetylcholine; Amides; Catecholamines; Histamine; Humans; Kinins; Pain; Potassium; Serotonin | 1969 |
[Clinical trials in the therapy of peptic ulcer. 3. Ambulatary therapy of uncomplicated duodenal ulcer with diverse anticholinergic agents].
Topics: Antacids; Benzilates; Choline; Delayed-Action Preparations; Duodenal Ulcer; Gastric Juice; Heartburn | 1970 |
Headache and eye pain.
Topics: Brain Neoplasms; Cerebrovascular Disorders; Eye Diseases; Facial Neuralgia; Giant Cell Arteritis; He | 1967 |
[Anatomo-physiopathology of pain].
Topics: Histamine; Humans; Kinins; Pain; Perception; Sensory Receptor Cells; Serotonin; Thalamus | 1967 |
Vocalization response of puppies to intra-arterial administration of bradykinin and other algesic agents, and mode of actions of blocking agents.
Topics: Acetylcholine; Age Factors; Analgesics; Animals; Atropine; Barium; Bradykinin; Catheterization; Chlo | 1968 |