Page last updated: 2024-10-18

histamine and Pain

histamine has been researched along with Pain in 241 studies

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"Oral administration of morphine caused analgesia without modulating itch intensities but increased neurogenic inflammation in response to histamine, suggesting that different opioid mechanisms in histaminergic and non-histaminergic neurons evoke neurogenic inflammation."9.69Effects of oral morphine on experimentally evoked itch and pain: a randomized, double-blind, placebo-controlled trial. ( Ammitzbøll, N; Arendt-Nielsen, L; Drewes, AM; Lo Vecchio, S; Okutani, H, 2023)
"Diacerein (DCN), an analogue of rhein (a glycosidal compound of natural origin), is currently used in the treatment of osteoarthritis and is given a fast-track designation for development to treat epidermolysis bullosa (EB)."9.22Therapeutic Potential of Diacerein in Management of Pain. ( Jain, M; Joharapurkar, A; Patel, V, 2022)
"Cowhage, capsaicin and histamine, all applied via spicules, were used to induce itch and pain-related sensations in 15 male and 15 female subjects."9.20Gender differences in itch and pain-related sensations provoked by histamine, cowhage and capsaicin. ( Forster, C; Handwerker, HO; Hartmann, EM, 2015)
" Immediately after the injection of 100 µg histamine on both arms, subjects received topical treatment and pruritus was subsequently assessed with visual analogue scale (VASpruritus) and Eppendorfer questionnaire."9.20A double-blind, randomized clinical study to determine the efficacy of benzocaine 10% on histamine-induced pruritus and UVB-light induced slight sunburn pain. ( Bauer, M; Lang-Zwosta, I; Nishino, K; Scherzer, T; Schwameis, R; Zeitlinger, M, 2015)
"We tested the hypothesis that the solvent for etomidate was a factor in the incidence of pain and other side effects after injection, and that these were associated with histamine release."9.09Solvent for etomidate may cause pain and adverse effects. ( Doenicke, AW; Hoernecke, R; Lorenz, W; Ostwald, P; Roizen, MF, 1999)
"A quantitative comparison was made of the effect of infiltration of local analgesics and topical analgesic cream (EMLA) on laser-induced pain and histamine-induced wheal, flare and itch."9.06A quantitative comparison of the effect of local analgesics on argon laser induced cutaneous pain and on histamine induced wheal, flare and itch. ( Arendt-Nielsen, L; Bjerring, P, 1990)
"Capsaicin nanoparticles could be useful in reducing pain and itch associated with pruritic diseases that are histamine-independent."8.12Topical Capsaicin in Poly(lactic-co-glycolic)acid (PLGA) Nanoparticles Decreases Acute Itch and Heat Pain. ( Chen, Z; Escamilla-Rivera, V; Jung, S; LaMotte, RH; Malewicz, NM; Oeck, S; Rattray, Z; Tang, X; Zhou, J, 2022)
"This study investigated whether itch induced by intra-epidermal histamine is subjected to modulation by a standardized conditioned pain modulation (CPM) paradigm in 24 healthy volunteers."7.83Conditioning pain stimulation does not affect itch induced by intra-epidermal histamine pricks but aggravates neurogenic inflammation in healthy volunteers. ( Andersen, HH; Arendt-Nielsen, L; Elberling, J; Imai, Y; Koenig, J; Petersen, KK, 2016)
"The present study was aimed to investigate the effects of microinjection of histamine and its H1, H2 and H3 receptor antagonists, mepyramine, ranitidine and thioperamide, respectively, into the anterior cingulate cortex (ACC) on pain-related behaviors induced by formalin in rats."7.81Effects of microinjection of histamine into the anterior cingulate cortex on pain-related behaviors induced by formalin in rats. ( Farshid, AA; Hamzeh-Gooshchi, N; Tamaddonfard, E, 2015)
"To date, suggestions that endothelin-1 (ET-1) causes nociception and pruritus are based on results in preclinical models in which responses to pruritic and nociceptive stimuli cannot be distinguished."7.78Endothelin-1 induces itch and pain in the mouse cheek model. ( Gomes, LO; Hara, DB; Rae, GA, 2012)
"Histamine and calcitonin gene-related peptide (CGRP) contribute to the pain perception."7.77Interaction of histamine and calcitonin gene-related peptide in the formalin induced pain perception in rats. ( Ghasri, S; Hamzely, A; Khoshkholgh Sima, B; Mobarakeh, JI; Nezhad, RM; Nunoki, K; Rahimi, AA; Takahashi, K; Torkaman-Boutorabi, A; Yanai, K, 2011)
"Both manual acupuncture and histamine injection of ST 36 can relieve pain in AIA rats, which may be closely related to its effect in activating mast cells in acupoint area."7.76[Acupoint-injection of histamine induced analgesic effect in acute adjuvant-induced-arthritis rats]. ( Ding, GH; Huang, M; Xie, YY, 2010)
"These data demonstrate that mast cells promote cystitis pain and bladder pathophysiology through the separable actions of histamine and TNF, respectively."7.74Mast cell-derived histamine mediates cystitis pain. ( Berry, RE; Bryce, PJ; Guichelaar, LA; Klumpp, DJ; Rudick, CN, 2008)
" The present study examined the effects of combinations of dextromethorphan and ketamine, two clinically used N-methyl-D-aspartate (NMDA) receptor antagonists, with amitriptyline on formalin-evoked behaviors and paw edema."7.72Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats. ( Reid, A; Sawynok, J, 2003)
"Possible central serotonergic and histaminergic modulation of acute peripheral inflammation was investigated in rats, adopting the formaldehyde-induced acute pedal inflammation as an experimental model."7.69Central serotonergic and histaminergic modulation of peripheral inflammation and nociception in rats. ( Dumka, VK; Raviprakash, V; Tandan, SK; Tripathi, HC, 1996)
"The effect of menthol and alcohol as its vehicle on thermal sensations, pain, experimental itch and irritation were studied in 18 subjects, using a computerized thermal sensory analyzer, laser Doppler flowmetry and an evaporimeter for transepidermal water loss (TEWL)."7.69Effect of topically applied menthol on thermal, pain and itch sensations and biophysical properties of the skin. ( Hui, XY; Maibach, H; Szolar, C; Yosipovitch, G, 1996)
"Deep muscle pain is often associated with sensory changes in the corresponding dermatome."6.71Interaction between histamine-induced itch and experimental muscle pain. ( Baron, R; Binder, A; Jensen, TS; Schattschneider, J; Schwarz, K; Wasner, G, 2004)
"Oral administration of morphine caused analgesia without modulating itch intensities but increased neurogenic inflammation in response to histamine, suggesting that different opioid mechanisms in histaminergic and non-histaminergic neurons evoke neurogenic inflammation."5.69Effects of oral morphine on experimentally evoked itch and pain: a randomized, double-blind, placebo-controlled trial. ( Ammitzbøll, N; Arendt-Nielsen, L; Drewes, AM; Lo Vecchio, S; Okutani, H, 2023)
"Radiation-induced acute oral mucositis is associated with inflammation and pain."5.62Early radiation-induced oral pain signaling responses are reduced with pentoxifylline treatment. ( Lai, YE; Lascelles, BDX; Marcus, KL; Nolan, MW; Price, ML; Robertson, JB, 2021)
"Diacerein (DCN), an analogue of rhein (a glycosidal compound of natural origin), is currently used in the treatment of osteoarthritis and is given a fast-track designation for development to treat epidermolysis bullosa (EB)."5.22Therapeutic Potential of Diacerein in Management of Pain. ( Jain, M; Joharapurkar, A; Patel, V, 2022)
"Cowhage, capsaicin and histamine, all applied via spicules, were used to induce itch and pain-related sensations in 15 male and 15 female subjects."5.20Gender differences in itch and pain-related sensations provoked by histamine, cowhage and capsaicin. ( Forster, C; Handwerker, HO; Hartmann, EM, 2015)
" Immediately after the injection of 100 µg histamine on both arms, subjects received topical treatment and pruritus was subsequently assessed with visual analogue scale (VASpruritus) and Eppendorfer questionnaire."5.20A double-blind, randomized clinical study to determine the efficacy of benzocaine 10% on histamine-induced pruritus and UVB-light induced slight sunburn pain. ( Bauer, M; Lang-Zwosta, I; Nishino, K; Scherzer, T; Schwameis, R; Zeitlinger, M, 2015)
" Histamine always provoked itching and rarely pain, capsaicin always pain but never itching."5.10Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens. ( Handwerker, HO; Hilliges, M; Schmelz, M; Schmidt, R; Torebjork, HE; Weidner, C, 2003)
"We tested the hypothesis that the solvent for etomidate was a factor in the incidence of pain and other side effects after injection, and that these were associated with histamine release."5.09Solvent for etomidate may cause pain and adverse effects. ( Doenicke, AW; Hoernecke, R; Lorenz, W; Ostwald, P; Roizen, MF, 1999)
"We investigated the effects of tactile allodynia on the itch and mechanically evoked dysesthesiae produced by an intradermal injection of histamine in human volunteers."5.09Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia. ( Atanassoff, PG; Brull, SJ; Lamotte, RH; Silverman, DG; Zhang, J, 1999)
"We have studied experimentally induced itch (using histamine iontophoresis) and pain (using topical mustard oil) in healthy human volunteers, measured using visual analogue scale (VAS) ratings."5.08A comparison of the effects of noxious and innocuous counterstimuli on experimentally induced itch and pain. ( McMahon, SB; Ward, L; Wright, E, 1996)
"The effect of psychological pain reduction on the cutaneous inflammatory process was investigated by studying the effect of hypnotically induced analgesia on the flare reaction of cutaneous histamine prick tests."5.06The effect of hypnotically induced analgesia on flare reaction of the cutaneous histamine prick test. ( Bjerring, P; Zachariae, R, 1990)
"A quantitative comparison was made of the effect of infiltration of local analgesics and topical analgesic cream (EMLA) on laser-induced pain and histamine-induced wheal, flare and itch."5.06A quantitative comparison of the effect of local analgesics on argon laser induced cutaneous pain and on histamine induced wheal, flare and itch. ( Arendt-Nielsen, L; Bjerring, P, 1990)
"Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy."4.40Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023)
"Capsaicin nanoparticles could be useful in reducing pain and itch associated with pruritic diseases that are histamine-independent."4.12Topical Capsaicin in Poly(lactic-co-glycolic)acid (PLGA) Nanoparticles Decreases Acute Itch and Heat Pain. ( Chen, Z; Escamilla-Rivera, V; Jung, S; LaMotte, RH; Malewicz, NM; Oeck, S; Rattray, Z; Tang, X; Zhou, J, 2022)
" Anti-inflammatory activity was determined by the carrageenan-induced and histamine-induce Rat paw edema in rats, analgesic activity was determined by acetic acid-Induced writhing test, formalin-induced hind paw licking in mice and Tail immersion test."4.12Evaluation of anti-inflammatory and analgesic effects of Hertia intermedia (Boiss.) Kuntze extract. ( Arslan, M; Iqbal, J; Jabbar, A; Jan, SU; Khan, Z; Mehjabeen, -; Muhammad, S; Qadir, A; Shah, PA; Soomer Khan, N; Younis, M, 2022)
"Short-lasting tingling dermal pain appears immediately upon exposure to sweating stimuli, regardless of developing eruptions and/or presence of hypohidrosis, but possibly in association with sweat and plasma histamine."4.12Clinical and histological characterization of transient dermal pain triggered by sweating stimuli. ( Harada, N; Hide, M; Ishii, K; Mizuno, H; Okamoto, M; Takahagi, S; Tanaka, A; Yanagida, N, 2022)
" Compared to the naïve mice, a significant increase in itch-related behaviors was observed in the CCD mice after the injection of pruritogens including histamine and BAM8-22, but not after the injection of capsaicin, although all the above agents evoked enhanced pain-related behaviors toward the injected site."4.02The role of pruriceptors in enhancing sensitivity to pruritogens in a murine chronic compression model of dorsal root ganglion. ( Fang, Y; Ma, C; Tao, J; Wang, T, 2021)
" For mechanism investigation, it was used hot plate test to induce opioid receptors, a histamine and serotonin test to induce edema paw, finally, for the TRPV1 receptor, it was used the capsaicin test."4.02Pharmacological studies on aqueous extract of Launaea arborescens from southwest Algeria. ( Belboukhari, N; Cheriti, A; Ould El Hadj-Khelil, A; Seddiki, LS; Sekkoum, K; Sulaiman, MR, 2021)
"Although TRPA1, SP, histamine and 5-hydroxytryptamine (5-HT) have recognized contribution to nociceptive mechanisms, little is known about how they interact with each other to mediate inflammatory pain in vivo."3.85TRPA1, substance P, histamine and 5-hydroxytryptamine interact in an interdependent way to induce nociception. ( de Oliveira Borges, M; Fischer, L; Lavoranti, MI; Martynhak, BJ; Miksza, AF; Parada, CA; Sardi, NF; Tambeli, CH, 2017)
"We conclude that activation of mechano-insensitive nociceptors is sufficient to provoke itch by histamine- and acid-induced pain."3.83Mechano-sensitive nociceptors are required to detect heat pain thresholds and cowhage itch in human skin. ( Benrath, J; Dusch, M; Ringkamp, M; Rukwied, R; Schmelz, M; van der Ham, J; Weinkauf, B, 2016)
"This study investigated whether itch induced by intra-epidermal histamine is subjected to modulation by a standardized conditioned pain modulation (CPM) paradigm in 24 healthy volunteers."3.83Conditioning pain stimulation does not affect itch induced by intra-epidermal histamine pricks but aggravates neurogenic inflammation in healthy volunteers. ( Andersen, HH; Arendt-Nielsen, L; Elberling, J; Imai, Y; Koenig, J; Petersen, KK, 2016)
" At same doses, SP-Ul was tested on Wistar rats on paw edema elicited by different irritants (carrageenan, dextran, bradykinin, histamine or serotonin)."3.83Analgesic and anti-inflammatory actions on bradykinin route of a polysulfated fraction from alga Ulva lactuca. ( Benevides, NM; Bezerra, MM; Chaves, HV; de Araújo, IW; de Sousa Oliveira Vanderlei, E; Maciel, GF; Pereira, KM; Quinderé, AL; Ribeiro, KA; Ribeiro, NA; Rodrigues, JA; Silva, JF, 2016)
"The present study was aimed to investigate the effects of microinjection of histamine and its H1, H2 and H3 receptor antagonists, mepyramine, ranitidine and thioperamide, respectively, into the anterior cingulate cortex (ACC) on pain-related behaviors induced by formalin in rats."3.81Effects of microinjection of histamine into the anterior cingulate cortex on pain-related behaviors induced by formalin in rats. ( Farshid, AA; Hamzeh-Gooshchi, N; Tamaddonfard, E, 2015)
" The PLS (30 mg kg(-1)) significantly reduced the paw oedema induced by carrageenan, dextran, histamine and serotonin and also was able to significantly inhibit leucocyte migration into the peritoneal cavity and decrease the concentration of myeloperoxidase (MPO) in paw tissue."3.80Polysaccharide isolated from Agardhiella ramosissima: chemical structure and anti-inflammation activity. ( Barbosa, AL; Batista, JA; Brito, TV; Chaves, LS; de Paula, RC; Dias, EG; Feitosa, JP; Freitas, AL; Medeiros, JV; Melo, MR; Prudêncio, RS; Ribeiro, RA; Silva, RO; Souza, MH, 2014)
" & Naudin (Ss-EtOH) in the experimental models of edema induced by carrageenan, dextran, or histamin and nociception induced by chemical stimuli, such as acetic acid, formalin, capsaicin, or glutamate."3.80Anti-inflammatory and antinociceptive effects of Sterculia striata A. St.-Hil. & Naudin (Malvaceae) in rodents. ( Almeida, FR; Amaral, MP; Chaves, MH; Costa, DA; Figueiredo, KA; Júnior, FB; Oliveira, FA; Oliveira, IS; Oliveira, RC; Silva, FV, 2014)
" in wistar rats 1 hr before carrageenan, dextran, histamine or serotonin, were tested in paw oedema models."3.80Peripheral antinociception and anti-inflammatory effects of sulphated polysaccharides from the alga Caulerpa mexicana. ( Benevides, NM; Bezerra, MM; Carneiro, JG; Chaves, HV; Coura, CO; de Araújo, IW; de Sousa Oliveira Vanderlei, E; Quinderé, AL; Rodrigues, JA; Souza, RB, 2014)
"Intrathecal application of morphine is among the most powerful methods used to treat severe chronic pain."3.79Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons. ( Giesler, GJ; Moser, HR, 2013)
" Moreover, similar to wild-type littermates, Nf1± mice developed inflammation-induced heat and mechanical hypersensitivity, capsaicin-induced nocifensive behavior, histamine-dependent or -independent scratching, and chronic constriction injury-induced cold allodynia."3.79Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1. ( Brenner, DS; Gereau, RW; Gutmann, DH; O'Brien, DE, 2013)
"To date, suggestions that endothelin-1 (ET-1) causes nociception and pruritus are based on results in preclinical models in which responses to pruritic and nociceptive stimuli cannot be distinguished."3.78Endothelin-1 induces itch and pain in the mouse cheek model. ( Gomes, LO; Hara, DB; Rae, GA, 2012)
"The anti-oedemogenic activity of the hydroalcoholic extract of the roots of Byttneria herbacea (HBH) was evaluated against carrageenan and histamine induced rat paw oedema, acetic acid induced writhing and histamine induced vascular permeability in mice."3.78A report on anti-oedemogenic activity of Byttneria herbacea roots--possible involvement of histamine receptor (type I). ( Bhuvaneswari, N; Fukui, H; Islam, MN; Karmakar, S; Mizuguchi, H; Samanta, SK; Sarkar, L; Sen, T, 2012)
" Nevertheless, the anti-inflammatory activity was tested in carrageenan induced paw edema and histamine induced inflammatory tests."3.78Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant. ( Khan, H; Muhammad, N; Saeed, M, 2012)
" CETD was evaluated for anti-inflammatory activity in experimental acute (carrageenan-, histamine- and serotonin-induced paw oedema) and chronic models (cotton pellet-induced granuloma) in Wistar albino rats."3.78Protective role of the triterpenoid-enriched extract of Trichosanthes dioica root against experimentally induced pain and inflammation in rodents. ( Bhattacharya, S; Haldar, PK, 2012)
" Itch and pain were induced using the following somatosensory stimuli: electrical stimulation, histamine iontophoresis and the cold pressor test."3.78Role of induced negative and positive emotions in sensitivity to itch and pain in women. ( Evers, AW; Kraaimaat, FW; Kroeze, S; van de Kerkhof, PC; van Laarhoven, AI; van Riel, PL; Walker, AL; Wilder-Smith, OH, 2012)
"Histamine and calcitonin gene-related peptide (CGRP) contribute to the pain perception."3.77Interaction of histamine and calcitonin gene-related peptide in the formalin induced pain perception in rats. ( Ghasri, S; Hamzely, A; Khoshkholgh Sima, B; Mobarakeh, JI; Nezhad, RM; Nunoki, K; Rahimi, AA; Takahashi, K; Torkaman-Boutorabi, A; Yanai, K, 2011)
" To this end, electrical stimuli were applied before and after histamine application (HPCS) to female patients with psoriasis and healthy female control subjects."3.76Heterotopic pruritic conditioning and itch--analogous to DNIC in pain? ( Evers, AWM; Kraaimaat, FW; van de Kerkhof, PCM; van Laarhoven, AIM; Wilder-Smith, OH, 2010)
"Both manual acupuncture and histamine injection of ST 36 can relieve pain in AIA rats, which may be closely related to its effect in activating mast cells in acupoint area."3.76[Acupoint-injection of histamine induced analgesic effect in acute adjuvant-induced-arthritis rats]. ( Ding, GH; Huang, M; Xie, YY, 2010)
" These mice showed profound scratching deficits in response to all of the itching (pruritogenic) stimuli tested, irrespective of their histamine dependence."3.75Cellular basis of itch sensation. ( Chen, ZF; Liu, XY; Meng, XL; Sun, YG; Yin, J; Zhao, ZQ, 2009)
" Austroplenckia populnea bark hydroalcoholic crude extract, and its hexane, chloroform and ethyl acetate fractions, obtained by partition, as well as the isolated populnoic acid were investigated for their anti-inflammatory (carrageenan, dextran and histamine-induced rat paw oedema, histamine-induced increase in vascular permeability, and granulomatous tissue induction) and analgesic activities (writhing and hot plate tests)."3.74Anti-inflammatory and antinociceptive activities of extract, fractions and populnoic acid from bark wood of Austroplenckia populnea. ( Andrade, SF; Bastos, JK; Cardoso, LG; Carvalho, JC, 2007)
" For evaluation of inflammation carrageenan-, histamine- and serotonin-induced paw edema served as acute models and formaldehyde-induced arthritis served as a chronic model in rats."3.74Antinociceptive and anti-inflammatory effects of Thespesia populnea bark extract. ( Gunnam, KK; Parle, M; Vasudevan, M, 2007)
"These data demonstrate that mast cells promote cystitis pain and bladder pathophysiology through the separable actions of histamine and TNF, respectively."3.74Mast cell-derived histamine mediates cystitis pain. ( Berry, RE; Bryce, PJ; Guichelaar, LA; Klumpp, DJ; Rudick, CN, 2008)
" indica dry extract (100, 200 and 400 mg kg-1) exhibited dose dependent and significant anti-inflammatory activity in acute (carrageenean and histamine induced hind paw oedema, p < 0."3.74Anti-inflammatory and anti-nociceptive activities of Fumaria indica whole plant extract in experimental animals. ( Gupta, PK; Rao, CV; Verma, AR; Vijayakumar, M, 2007)
" To study the participation of histamine in pain perception, histidine decarboxylase knockout mice were examined for pain threshold by means of three different kinds of noxious stimuli: thermal nociception (hot-plate, tail-flick, and paw-withdrawal), mechanical nociception (tail-pressure), and chemical nociception (formalin test and capsaicin test)."3.73Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: a study in histidine decarboxylase gene knockout mice. ( Kato, M; Kuramasu, A; Mobarakeh, JI; Orito, T; Sakurada, S; Sakurai, E; Yanai, K; Yoshida, A, 2005)
"Role in pain sensation of both nociceptin (NC), the bioactive heptadecapeptide sequence of preproorphaninFQ and of histamine has been widely evidenced in the central nervous system (CNS)."3.73[Effect of nociceptin on histamine and serotonin release in the central nervous system]. ( Gyenge, M; Hantos, M; Laufer, R; Tekes, K, 2006)
" The present study examined the effects of combinations of dextromethorphan and ketamine, two clinically used N-methyl-D-aspartate (NMDA) receptor antagonists, with amitriptyline on formalin-evoked behaviors and paw edema."3.72Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats. ( Reid, A; Sawynok, J, 2003)
"Dried leaves extract from Bouchea fluminensis was assessed in anti-inflammatory (mouse paw edema) and analgesic models (acetic acid-induced writhings and hot plate)."3.72Anti-inflammatory and analgesic activity of Bouchea fluminensis. ( Costa, VB; Coube, CS; Fernandes, PD; Leitão, SG; Marinho, BG; Matheus, ME, 2003)
"5, 5 and 10 mg kg (-1)) was investigated and compared with diclofenac sodium (5 mg kg (-1)) using the formalin-, histamine-, and carrageenan-induced paw oedema and cotton pellet granuloma tests."3.71Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice. ( Büyükokuroğlu, ME, 2002)
"Nicotine evokes pain in the skin and oral mucosa and excites a subpopulation of cutaneous nociceptors, but little is known about the central transmission of chemogenic pain."3.70Activation of spinal wide dynamic range neurons by intracutaneous microinjection of nicotine. ( Carstens, E; Jinks, SL, 1999)
"Pain-producing concentrations of capsaicin (30-300 ng/ml) were applied to the nasal mucosal surface both before and late into the pollen season."3.69Effects of topical capsaicin in seasonal allergic rhinitis. ( Andersson, M; Greiff, L; Persson, CG; Svensson, C, 1995)
"The effect of menthol and alcohol as its vehicle on thermal sensations, pain, experimental itch and irritation were studied in 18 subjects, using a computerized thermal sensory analyzer, laser Doppler flowmetry and an evaporimeter for transepidermal water loss (TEWL)."3.69Effect of topically applied menthol on thermal, pain and itch sensations and biophysical properties of the skin. ( Hui, XY; Maibach, H; Szolar, C; Yosipovitch, G, 1996)
"Sympathetic reflex responses were elicited in human volunteers by sustained selective excitation of nociceptors by noxious chemicals, namely topical application of mustard oil which elicited burning pain, or histamine which induced itching in a skin area of 5 cm2 on the volar aspect of one forearm."3.69Asymmetry and time-course of cutaneous sympathetic reflex responses following sustained excitation of chemosensitive nociceptors in humans. ( Handwerker, HO; Koltzenburg, M; Magerl, W; Schmitz, JM, 1996)
"Possible central serotonergic and histaminergic modulation of acute peripheral inflammation was investigated in rats, adopting the formaldehyde-induced acute pedal inflammation as an experimental model."3.69Central serotonergic and histaminergic modulation of peripheral inflammation and nociception in rats. ( Dumka, VK; Raviprakash, V; Tandan, SK; Tripathi, HC, 1996)
"Time course of plasma extravasation in neurogenic inflammation elicited by histamine iontophoresis and topical capsaicin application was measured in vivo by a modified intradermal microdialysis technique in humans."3.69Plasma extravasation and neuropeptide release in human skin as measured by intradermal microdialysis. ( Averbeck, B; Bickel, A; Luz, O; Schmelz, M, 1997)
"Data have been collected indicating possible functions for histamine in brain but there are only a very few data, collected exclusively with behavioural tests, about the effects of histamine on the perception of the pain, an important aspect in the homeostasis of the human body."3.68Electrophysiological correlates for antinociceptive effects of histamine after intracerebral administration to the rat. ( Braga, PC; Guidobono, E; Netti, C; Pecile, A; Sibilia, V, 1992)
"The investigation of algoinductor (histaminergic) and peptidergic relations in peripheral pain reaction of taste was performed by using of different histamine liberators (applied on tongue)."3.68[Role of pain component in the organization of chemosensory taste reaction]. ( Liubimova, ZV; Marinova, TIu; Nikitina, AA; Subrakova, SA, 1991)
" Histamine was iontophoretically applied to the receptive fields of these units for 20 or 30 s and was found to provoke itching sensations lasting several minutes, together with wheal and flare responses."3.68Discharge patterns of human C-fibers induced by itching and burning stimuli. ( Forster, C; Handwerker, HO; Kirchhoff, C, 1991)
"Intraarterial injection of histamine into the isolated perfused rabbit ear causes a reflex fall in mean arterial blood pressure by stimulation of perivascular pain receptors."3.66Dependence of histamine-evoked nociception on prostaglandin release. ( Juan, H, 1981)
" In order to determine the nervous outflow from skeletal muscle during chemically induced muscle pain, the impulse activity of various types of muscle afferents in response to close intra-arterial injections of pain-producing substances (bradykinin, 5-hydroxytryptamine, histamine and potassium) was studied in anaesthetized cats using a single fibre recording technique."3.65Nervous outflow from skeletal muscle following chemical noxious stimulation. ( Mense, S, 1977)
"Because pain has been more extensively studied, some extrapolations to itch can be proposed and verified by experiments."2.72Itch processing in the brain. ( Ben Salem, D; Carré, JL; Dufor, O; Misery, L; Najafi, P, 2021)
"Deep muscle pain is often associated with sensory changes in the corresponding dermatome."2.71Interaction between histamine-induced itch and experimental muscle pain. ( Baron, R; Binder, A; Jensen, TS; Schattschneider, J; Schwarz, K; Wasner, G, 2004)
"Itch and pain were scored on a visual analogue scale at regular intervals."2.70Topically applied aspirin decreases histamine-induced wheal and flare reactions in normal and SLS-inflamed skin, but does not decrease itch. A randomized, double-blind and placebo-controlled human study. ( Benfeldt, E; Jensen, SB; Menné, T; Serup, J; Thomsen, JS, 2002)
"Histamine 10 microl was injected into each bleb, and the resulting magnitude of itch estimated."2.69Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia. ( Atanassoff, PG; Brull, SJ; Greenquist, K; Lamotte, RH; Silverman, DG; Zhang, J, 1999)
"Headache is the most prominent and clinically important symptom of migraine but its origin is still enigmatic."2.45Migraine: where and how does the pain originate? ( Messlinger, K, 2009)
"Itch (pruritus) is a sensory phenomenon characterized by a (usually) negative affective component and the initiation of a special behavioral act, i."2.44TRP channels as novel players in the pathogenesis and therapy of itch. ( Bíró, T; Dobrosi, N; Géczy, T; Marincsák, R; Paus, R; Tóth, BI, 2007)
"Atopic dermatitis is often associated with increased pain."1.91Crisaborole Inhibits Itch and Pain by Preventing Neutrophil Infiltration in a Mouse Model of Atopic Dermatitis. ( Akiyama, T; Bystrom, L; Ishida, H; Markan, A; Pavlenko, D; Todurga Seven, Z; Verpile, R, 2023)
"Although itch and pain have many similarities, they are completely different in perceptual experience and behavioral response."1.91Microglia are involved in regulating histamine-dependent and non-dependent itch transmissions with distinguished signal pathways. ( Li, BM; Liu, Y; Liu, YU; Ma, CL; Mou, B; Pan, H; Peng, J; Xiong, MT; Yang, Y; Yun, X; Zhang, JY; Zhang, QR; Zhao, HX, 2023)
"Radiation-induced acute oral mucositis is associated with inflammation and pain."1.62Early radiation-induced oral pain signaling responses are reduced with pentoxifylline treatment. ( Lai, YE; Lascelles, BDX; Marcus, KL; Nolan, MW; Price, ML; Robertson, JB, 2021)
"PmV also induced hyperalgesia in both mice and rats, evaluated through electronic von Frey and rat paw pressure test, respectively."1.48Potamotrygon motoro stingray venom induces both neurogenic and inflammatory pain behavior in rodents. ( Barbaro, KC; Kimura, LF; Picolo, G; Santos-Neto, M, 2018)
"Chronic pain affects the lives of millions yearly, but few new treatments are available."1.46A novel zebrafish-based model of nociception. ( DeBerry, JJ; Dewberry, LS; Sorge, RE; Taylor, JC; Totsch, SK; Watts, SA; Yessick, LR, 2017)
" tragacantha exhibited anti-inflammatory and analgesic properties and they are also safe for medicinal use."1.43Phytochemical screening, safety evaluation, anti-inflammatory and analgesic studies of the leaf extracts of Sterculia tragacantha. ( Abatan, MO; Adedapo, AA; Mogbojuri, OM, 2016)
"Systemic mastocytosis is characterised by abnormal proliferation of mast cells in various organs."1.42[Vulvar oedema revealing systemic mastocytosis]. ( Aubin, F; Daguindau, E; Deveza, E; Girardin, M; Humbert, P; Locatelli, F; Pelletier, F; Valmary-Degano, S, 2015)
"Edema was evaluated by the increase in articular diameter (AD; mm), and PL was measured by the amount of Evans blue dye in the synovial fluid (PL; μg/mL)."1.39Histamine produces opposing effects to serotonin in the knee joint of rats. ( de Oliveira, DT; Eto, C; Souza-Silva, E; Stein, T; Tonussi, CR, 2013)
"treatment with histamine increased the phosphorylation of the NR1 subunit of N-methyl-D-aspartate (NMDA) receptors."1.37Involvement of glial cells in the nociceptive behaviors induced by a high-dose of histamine administered intrathecally. ( Iwata, Y; Katsuyama, S; Komatsu, T; Mizoguchi, H; Onodera, K; Orito, T; Sakurada, S; Sakurada, T; Watanabe, C; Watanabe, H; Yonezawa, A, 2011)
"Central neuropathic pain following lesions within the CNS, such as spinal cord injury, is one of the most excruciating types of chronic pain and one of the most difficult to treat."1.35Residual spinothalamic tract pathways predict development of central pain after spinal cord injury. ( Engel, S; Lee, BB; McLachlan, E; Wasner, G, 2008)
"(AR) has been used to treat pain and inflammation in Korea."1.32Mechanism of anti-nociceptive effects of Asarum sieboldii Miq. radix: potential role of bradykinin, histamine and opioid receptor-mediated pathways. ( Gao Zhang, C; Kim, SJ; Taek Lim, J, 2003)
"The ability of allergens to induce hyperalgesia in immunoglobulin E (IgE)-sensitized rats was investigated."1.32Combined action of vasoactive amines and bradykinin mediates allergen-evoked thermal hyperalgesia in rats. ( Calixto, JB; Cordeiro, RS; e Silva, PM; Lavich, TR; Martins, MA, 2003)
"Histamine has an antinociceptive effect in the brain and may be involved in opioid-induced analgesia."1.31Opposite modulation of histaminergic neurons by nociceptin and morphine. ( Eriksson, KS; Haas, HL; Stevens, DR, 2000)
"Diquat treatment increased the MMC number."1.31Chronic low-level administration of diquat increases the nociceptive response to gastric distension in rats: role of mast cells and tachykinin receptor activation. ( Anton, PM; Bueno, L; Fioramonti, J; Theodorou, V, 2001)
"Kyotorphin is a dipeptidic neuropeptide (tyrosine-arginine) that has specific receptor coupled to G(i) and phospholipase C and elicits Met-enkephalin release."1.31In vivo signal transduction of nociceptive response by kyotorphin (tyrosine-arginine) through Galpha(i)- and inositol trisphosphate-mediated Ca(2+) influx. ( Inoue, M; Ueda, H, 2000)
" The dose-response function was extremely steep, however, since other doses showed either no effect or behavioral toxicity."1.30Antinociceptive activity of impentamine, a histamine congener, after CNS administration. ( Hough, LB; Leurs, R; Menge, WM; Nalwalk, JW; Timmerman, H, 1999)
"Histamine was injected when the skin reaction was on the wane to determine its possible reactivation of inflammation."1.27[Reactivation of the algogenic component in experimental inflammation induced by histamine administration]. ( Chiarini, P; Duranti, R; Galletti, R; Guazzelli, R; Matassi, L; Strazzulla, G, 1983)
" Dose-response studies indicate that bradykinin is more potent than serotonin or histamine in respect of wealing."1.25Responses of skin blood vessels to bradykinin, histamine and 5-hydroxytryptamine. ( Greaves, M; Shuster, S, 1967)

Research

Studies (241)

TimeframeStudies, this research(%)All Research%
pre-199086 (35.68)18.7374
1990's34 (14.11)18.2507
2000's49 (20.33)29.6817
2010's52 (21.58)24.3611
2020's20 (8.30)2.80

Authors

AuthorsStudies
Takahagi, S1
Okamoto, M1
Ishii, K1
Tanaka, A1
Mizuno, H1
Harada, N1
Yanagida, N1
Hide, M1
Malewicz, NM2
Ieong, HF1
Oeck, S2
Kumowski, N1
Zhang, Z1
Shimada, SG3
LaMotte, RH6
Rattray, Z1
Jung, S1
Escamilla-Rivera, V1
Chen, Z1
Tang, X1
Zhou, J1
Seldeslachts, A1
Peigneur, S1
Mebs, D1
Tytgat, J1
Younis, M1
Iqbal, J1
Muhammad, S1
Jan, SU1
Jabbar, A1
Mehjabeen, -1
Qadir, A1
Soomer Khan, N1
Arslan, M1
Shah, PA1
Khan, Z1
Patel, V1
Joharapurkar, A1
Jain, M1
Lindgren, E1
Strote, J1
Wang, J2
Lu, C1
Liu, X1
Zhang, G1
Zhang, J3
Gao, M1
Liu, D1
Zhang, X1
Liu, Y2
Asgharieh-Ahari, M1
Tamaddonfard, E2
Erfanparast, A1
Soltanalinejad-Taghiabad, F1
Zuo, Y1
Wan, R1
Jiang, P1
Chen, X1
Li, L1
Hua, W1
Yang, Y1
Mou, B1
Zhang, QR1
Zhao, HX1
Zhang, JY1
Yun, X1
Xiong, MT1
Liu, YU1
Pan, H1
Ma, CL1
Li, BM1
Peng, J1
Pavlenko, D1
Todurga Seven, Z1
Bystrom, L1
Markan, A1
Verpile, R1
Ishida, H1
Akiyama, T3
Okutani, H1
Lo Vecchio, S2
Ammitzbøll, N1
Drewes, AM1
Arendt-Nielsen, L4
Ganchingco, JRC1
Fukuyama, T1
Yoder, JA1
Bäumer, W1
Alvaro, CG1
Braz, JM1
Bernstein, M1
Hamel, KA1
Craik, V1
Yamanaka, H1
Basbaum, AI1
Barry, DM1
Liu, XT1
Liu, B1
Liu, XY2
Gao, F1
Zeng, X1
Liu, J1
Yang, Q1
Wilhelm, S1
Yin, J2
Tao, A1
Chen, ZF3
Najafi, P1
Dufor, O1
Ben Salem, D1
Misery, L1
Carré, JL1
Price, ML1
Lai, YE1
Marcus, KL1
Robertson, JB1
Lascelles, BDX1
Nolan, MW1
Wang, T2
Tao, J1
Fang, Y1
Ma, C2
Seddiki, LS1
Belboukhari, N1
Ould El Hadj-Khelil, A1
Sulaiman, MR1
Sekkoum, K1
Cheriti, A1
Graceffa, RF1
Boezio, AA1
Able, J1
Altmann, S1
Berry, LM1
Boezio, C1
Butler, JR1
Chu-Moyer, M1
Cooke, M1
DiMauro, EF1
Dineen, TA1
Feric Bojic, E1
Foti, RS1
Fremeau, RT1
Guzman-Perez, A1
Gao, H1
Gunaydin, H1
Huang, H1
Huang, L1
Ilch, C1
Jarosh, M1
Kornecook, T1
Kreiman, CR1
La, DS1
Ligutti, J1
Milgram, BC1
Lin, MJ1
Marx, IE1
Nguyen, HN1
Peterson, EA1
Rescourio, G1
Roberts, J1
Schenkel, L1
Shimanovich, R1
Sparling, BA1
Stellwagen, J1
Taborn, K1
Vaida, KR1
Yeoman, J1
Yu, V1
Zhu, D1
Moyer, BD1
Weiss, MM1
Andersen, HH2
Elberling, J2
Yosipovitch, G5
Kimura, LF1
Santos-Neto, M1
Barbaro, KC1
Picolo, G1
Lipshetz, B1
Khasabov, SG1
Truong, H1
Netoff, TI1
Simone, DA1
Giesler, GJ2
Roberts, CA1
Giesbrecht, T1
Stancak, A1
Fallon, N1
Thomas, A1
Kirkham, TC1
Bartsch, VB1
Niehaus, JK1
Taylor-Blake, B2
Zylka, MJ2
Moser, HR1
O'Brien, DE1
Brenner, DS1
Gutmann, DH1
Gereau, RW1
Souza-Silva, E1
de Oliveira, DT1
Eto, C1
Stein, T1
Tonussi, CR1
Roberson, DP1
Gudes, S1
Sprague, JM1
Patoski, HA1
Robson, VK1
Blasl, F1
Duan, B1
Oh, SB1
Bean, BP1
Ma, Q1
Binshtok, AM1
Woolf, CJ1
van Laarhoven, AI4
Kraaimaat, FW5
Wilder-Smith, OH5
van Riel, PL2
van de Kerkhof, PC2
Evers, AW4
Batista, JA1
Dias, EG1
Brito, TV1
Prudêncio, RS1
Silva, RO1
Ribeiro, RA1
Souza, MH1
de Paula, RC1
Feitosa, JP1
Chaves, LS1
Melo, MR1
Freitas, AL1
Medeiros, JV1
Barbosa, AL1
Silva, FV1
Oliveira, IS1
Figueiredo, KA1
Júnior, FB1
Costa, DA1
Chaves, MH1
Amaral, MP1
Almeida, FR1
Oliveira, FA1
Oliveira, RC1
Nagamine, M1
Carstens, MI2
Carstens, E4
Carneiro, JG1
Rodrigues, JA2
de Sousa Oliveira Vanderlei, E2
Souza, RB1
Quinderé, AL2
Coura, CO1
de Araújo, IW2
Chaves, HV2
Bezerra, MM2
Benevides, NM2
Hartmann, EM1
Handwerker, HO10
Forster, C3
Funahashi, H1
Naono-Nakayama, R1
Ebihara, K1
Koganemaru, G1
Kuramashi, A1
Ikeda, T1
Nishimori, T1
Ishida, Y1
Bauer, M1
Schwameis, R1
Scherzer, T1
Lang-Zwosta, I1
Nishino, K1
Zeitlinger, M1
Weinkauf, B1
Dusch, M1
van der Ham, J1
Benrath, J1
Ringkamp, M2
Schmelz, M10
Rukwied, R2
Hamzeh-Gooshchi, N1
Farshid, AA1
Deveza, E1
Locatelli, F1
Girardin, M1
Valmary-Degano, S1
Daguindau, E1
Aubin, F1
Humbert, P1
Pelletier, F1
Peerdeman, KJ1
Donders, AR1
Hopman, MT1
Peters, ML1
Chuquilin, M1
Alghalith, Y1
Fernandez, KH1
Yuan, T1
Li, J1
Shen, L1
Zhang, W1
Xu, Y1
Zhu, J1
Huang, Y1
Sutherland, S1
Mogbojuri, OM1
Adedapo, AA1
Abatan, MO1
Imai, Y1
Petersen, KK1
Koenig, J1
Silva, JF1
Maciel, GF1
Ribeiro, NA1
Ribeiro, KA1
Pereira, KM1
Fischer, L2
Lavoranti, MI1
de Oliveira Borges, M1
Miksza, AF1
Sardi, NF1
Martynhak, BJ1
Tambeli, CH4
Parada, CA4
Taylor, JC1
Dewberry, LS1
Totsch, SK1
Yessick, LR1
DeBerry, JJ1
Watts, SA1
Sorge, RE1
Namer, B1
Carr, R1
Johanek, LM1
Wasner, G3
Lee, BB1
Engel, S1
McLachlan, E1
Messlinger, K1
Sikand, P1
Green, BG1
Sun, YG1
Zhao, ZQ1
Meng, XL1
Murotani, T1
Ishizuka, T1
Nakazawa, H1
Wang, X1
Mori, K1
Sasaki, K1
Ishida, T1
Yamatodani, A1
Maruani, A1
Vierron, E1
Machet, L1
Giraudeau, B1
Boucaud, A1
Kajihara, Y1
Murakami, M1
Imagawa, T1
Otsuguro, K1
Ito, S1
Ohta, T1
Wojtecka-Lukasik, E1
Ksiezopolska-Orlowska, K1
Gaszewska, E1
Krasowicz-Towalska, O1
Rzodkiewicz, P1
Maslinska, D1
Szukiewicz, D1
Maslinski, S1
Stadel, R1
Carpenter, AB1
Nalwalk, JW3
de Esch, IJ1
Janssen, E1
Hough, LB4
van Laarhoven, AIM2
van de Kerkhof, PCM2
Evers, AWM2
Huang, M1
Xie, YY1
Ding, GH1
Lagerström, MC1
Rogoz, K1
Abrahamsen, B1
Persson, E1
Reinius, B1
Nordenankar, K1
Olund, C1
Smith, C1
Mendez, JA1
Wood, JN1
Wallén-Mackenzie, A1
Kullander, K1
Mizoguchi, H3
Komatsu, T2
Iwata, Y2
Watanabe, C3
Watanabe, H3
Orito, T4
Katsuyama, S2
Yonezawa, A3
Onodera, K3
Sakurada, T3
Sakurada, S4
Vogelaar, ML1
van Riel, PLCM1
Hoffmeister, C1
Trevisan, G1
Rossato, MF1
de Oliveira, SM1
Gomez, MV1
Ferreira, J1
Mobarakeh, JI3
Torkaman-Boutorabi, A1
Rahimi, AA1
Ghasri, S1
Nezhad, RM1
Hamzely, A1
Khoshkholgh Sima, B1
Takahashi, K1
Nunoki, K1
Yanai, K4
Bhattacharya, S1
Haldar, PK1
Sarkar, L1
Bhuvaneswari, N1
Samanta, SK1
Islam, MN1
Sen, T1
Fukui, H2
Mizuguchi, H1
Karmakar, S1
Walker, AL1
Kroeze, S1
Gomes, LO1
Hara, DB1
Rae, GA1
Muhammad, N1
Saeed, M1
Khan, H1
McCoy, ES1
Büyükokuroğlu, ME1
Lavich, TR1
Cordeiro, RS1
Calixto, JB1
e Silva, PM1
Martins, MA1
Schmidt, R2
Weidner, C2
Hilliges, M2
Torebjork, HE2
Sawynok, J1
Reid, A1
Costa, VB1
Coube, CS1
Marinho, BG1
Matheus, ME1
Leitão, SG1
Fernandes, PD1
Kim, SJ2
Gao Zhang, C1
Taek Lim, J1
Krylova, SG1
Razina, TG1
Zueva, EP1
Amosova, EN1
Shilova, NV1
Dugina, YL1
Epstein, OI1
JACOB, J1
SZERB, J1
HOBBIGER, F1
GALLETTI, R4
ARCANGELI, P2
SKOUBY, AP1
HANSEL, FK1
ROSENTHAL, SR4
BRUMMER, P1
BORNEMISZA, G2
CSALAY, L2
HORVATH, G2
LUDANY, G2
STERN, P4
HUKOVIC, S3
BESAROVIC, Z1
SPUZIC, I1
RYVKINA, DE1
KUZNETSOVA, NE1
MOULTON, R1
SPECTOR, WG1
WILLOUGHBY, DA1
SZIRMAI, E1
DE WIED, D1
JINKS, R1
SPECKMANN, K2
MOECKEL, W1
COLLIER, HO3
LEE, IR1
TEODORESCU, P1
SAVULESCU, V1
ANDRONACHE, I1
FODOR, O1
MIKI, I1
BROADBENT, JL1
MARRA, N1
VECCHIET, L1
Ikoma, A3
Fartasch, M1
Heyer, G1
Miyachi, Y3
Handwerker, H3
MACKEY, WA1
MUFSON, I1
KLEINBAUM, H1
Schwarz, K2
Schattschneider, J2
Binder, A1
Jensen, TS1
Baron, R4
GIRARD, M1
FRAISSE, H1
Yoshida, A1
Sakurai, E1
Kuramasu, A1
Kato, M1
Fast, K1
Bernhard, JD1
Hosogi, M1
Vasudevan, M1
Gunnam, KK1
Parle, M1
Andrade, SF1
Cardoso, LG1
Carvalho, JC1
Bastos, JK1
Gyenge, M1
Hantos, M1
Laufer, R1
Tekes, K1
Bíró, T1
Tóth, BI1
Marincsák, R1
Dobrosi, N1
Géczy, T1
Paus, R1
Mochizuki, H1
Sadato, N1
Saito, DN1
Toyoda, H1
Tashiro, M1
Okamura, N1
Ting, E1
Roveroni, RC1
Ferrari, LF1
Lotufo, CM1
Veiga, MC1
Herde, L1
Strupf, M1
Watanabe, S1
Hattori, T1
Kanazawa, M1
Kano, M1
Fukudo, S1
Norbury, TA1
MacGregor, AJ1
Urwin, J1
Spector, TD1
McMahon, SB2
Ishiuji, Y1
Coghill, RC1
Patel, TS1
Dawn, A1
Fountain, J1
Oshiro, Y1
Rao, CV1
Verma, AR1
Gupta, PK1
Vijayakumar, M1
Rudick, CN1
Bryce, PJ1
Guichelaar, LA1
Berry, RE1
Klumpp, DJ1
Keele, CA3
Kaplan, HR1
Wolke, RE1
Malone, MH1
Greaves, M1
Shuster, S1
Agnoli, A1
Denaro, A1
Ceci, E1
Falaschi, P1
Juan, H2
Terenius, L1
Sweet, WH1
Monsereenusorn, Y1
Kongsamut, S1
Pezalla, PD1
Chiarini, P2
Duranti, R1
Strazzulla, G1
Guazzelli, R1
Matassi, L2
Terman, GW1
Shavit, Y1
Lewis, JW1
Cannon, JT1
Liebeskind, JC1
Van Hees, J1
Gybels, J1
Kuraishi, Y1
Nagasawa, T1
Hayashi, K1
Satoh, M1
Dray, A1
Greiff, L1
Svensson, C1
Andersson, M1
Persson, CG1
Feldmann, R1
Lindner, V1
Saguer, M1
Cambareri, JJ1
Afifi, MS1
Glass, PS1
Esposito, BF1
Camporesi, EM1
Koltzenburg, M2
Rajakulasingam, K1
Polosa, R1
Lau, LC1
Church, MK1
Holgate, ST1
Howarth, PH1
Koppert, W1
Reeh, PW1
Szolar, C2
Hui, XY2
Maibach, H2
Lamberti, C1
Bartolini, A1
Ghelardini, C1
Malmberg-Aiello, P1
Magerl, W1
Schmitz, JM1
Ward, L1
Wright, E1
Dumka, VK1
Tandan, SK1
Tripathi, HC1
Raviprakash, V1
Luz, O1
Averbeck, B1
Bickel, A1
Birklein, F1
Claus, D1
Riedl, B1
Neundörfer, B1
Leurs, R1
Menge, WM1
Timmerman, H1
Su, X1
Wachtel, RE1
Gebhart, GF1
Jinks, SL2
Ueda, H1
Inoue, M1
Atanassoff, PG2
Brull, SJ2
Greenquist, K1
Silverman, DG2
Doenicke, AW1
Roizen, MF1
Hoernecke, R1
Lorenz, W1
Ostwald, P1
Eriksson, KS1
Stevens, DR1
Haas, HL1
Harasawa, K1
Kim, MS1
Cunha, FQ1
Ferreira, SH2
Anton, PM1
Theodorou, V1
Fioramonti, J1
Bueno, L1
Drzezga, A1
Darsow, U1
Treede, RD2
Siebner, H1
Frisch, M1
Munz, F1
Weilke, F1
Ring, J1
Schwaiger, M1
Bartenstein, P1
Kashiba, H1
Senba, E1
Lischetzki, G1
Kleinert, A1
Olsen, UB1
Eltorp, CT1
Ingvardsen, BK1
Jørgensen, TK1
Lundbaek, JA1
Thomsen, C1
Hansen, AJ1
Thomsen, JS2
Sonne, M1
Benfeldt, E2
Jensen, SB2
Serup, J2
Menné, T2
Ørstavik, K1
Torebjörk, E1
Greenberg, S1
Palmer, GC1
Sewell, RD1
Spencer, PS1
Peacock, EE1
Mense, S3
Greenbaum, LM1
Nishi, K1
Sakanashi, M1
Takenaka, F1
Loux, JJ1
Smith, S1
Salem, H1
Greaves, MW1
Corti, F1
Hiss, E1
Hui, KS1
Ivey, KJ1
Khayutin, VM1
Baraz, LA1
Lukoshkova, EV1
Sonina, RS1
Chernilovskaya, PE1
Simons, FE1
Gillespie, CA1
Simons, KJ1
Braga, PC1
Sibilia, V1
Guidobono, E1
Pecile, A1
Netti, C1
Seltzer, Z1
Paran, Y1
Eisen, A1
Ginzburg, R1
Subrakova, SA1
Liubimova, ZV1
Marinova, TIu1
Nikitina, AA1
Kirchhoff, C1
Oluyomi, AO1
Hart, SL1
Bjerring, P3
Zachariae, R1
Himmelfarb, GN1
Schumilowa, IJ1
Klimczak, J1
Manni, E1
Draicchio, F1
Pettorossi, VE1
Carobi, C1
Grassi, S1
Bortolami, R1
Lucchi, ML1
Glick, SD1
Su, K1
Broton, JG2
Sessle, BJ2
Hu, JW1
Martin, J1
Pinsky, L1
DiGeorge, AM1
Kane, J1
Downie, AW1
Marcotte, DB1
Perez-Reyes, M1
Belcher, RW1
Czarnetzki, BM1
Carney, JF1
Gardner, E1
Avis, HH1
Lembeck, F1
James, GW1
Schneider, C1
Inoki, R1
Garcia Leme, J1
Lico, M1
Fordtran, JS1
Morawski, SG1
Richardson, CT1
Jannetta, PJ1
Amery, A1
Bossaert, H1
Deruyttere, M1
Vanderlinden, L1
Verstraete, M1
Schmidt, RF1
Popkin, RJ1
Makarov, PO1
Safronova, LG1
Musto, P1
Barile, C1
Graziani, M1
Gütz, HJ1
Berndt, H1
Wolff, G1
Goldor, H1
Zaffiri, O1
Del Prete, D1
Staldi, GF1
Taira, N1
Nakayama, K1
Hashimoto, K1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Organ Protective Effect of Histamine H1 Receptor Antagonist In Patients With Severe Burns: A Clinical Study[NCT06126991]Phase 1/Phase 232 participants (Anticipated)Interventional2023-11-01Recruiting
Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444]Phase 213 participants (Actual)Interventional2017-05-23Terminated (stopped due to Efficacy was not seen after interim analysis)
Genetic, Epigenetic, Psychosocial, and Biological Determinants of Post-surgical Pain After Pectus or Spine Surgery[NCT04031716]600 participants (Anticipated)Interventional2018-07-06Enrolling by invitation
Impact of Photobiomodulation on Pain During Orthodontic Treatment[NCT05361616]50 participants (Anticipated)Interventional2023-04-17Recruiting
A Randomized Controlled Trial Evaluating Three Non-invasive Analgesic Techniques in Pain Prevention During Injections[NCT03974633]Phase 4100 participants (Actual)Interventional2018-02-24Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Peak Itch Intensity Between the Vehicle and Active Treatments (Individual and KeAmLi-combo).

"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes

InterventionIntensity score (Mean)
Topical KeAmLi Combo62.7
Topical Ketamine63.1
Topical Amitriptyline69.2
Topical Lidocaine65.8
Topical Vehicle61.9

Mechanical Thresholds (Mechanical Detection and Pain).

Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes

,,,,
InterventionmN (Mean)
Mechanical Detection ThresholdMechanical Pain Threshold
Topical Amitriptyline3.573423965152.4768146
Topical KeAmLi Combo3.519376956152.3293608
Topical Ketamine3.464204768135.9
Topical Lidocaine3.546037659126.9
Topical Vehicle3.525692637148.7138273

Thermal Threshold Detection (Warmth and Heat Pain)

Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes

,,,,
InterventionDegrees celsius (Mean)
Warm Detection ThresholdHeat Pain Threshold
Topical Amitriptyline33.940.0
Topical KeAmLi Combo33.639.8
Topical Ketamine34.040.0
Topical Lidocaine33.739.4
Topical Vehicle33.839.7

Reviews

23 reviews available for histamine and Pain

ArticleYear
Therapeutic Potential of Diacerein in Management of Pain.
    Current drug research reviews, 2022, Volume: 14, Issue:3

    Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cytokines; Glutamates; Histam

2022
The seven day itch: A delayed histamine reaction to stingray injury.
    The American journal of emergency medicine, 2023, Volume: 66

    Topics: Animals; Bites and Stings; Histamine; Humans; Pain; Skates, Fish; Water

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Itch processing in the brain.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2021, Volume: 35, Issue:5

    Topics: Brain; Histamine; Humans; Mucuna; Pain; Pruritus

2021
Where Is Itch Represented in the Brain, and How Does it Differ from Pain? An Activation Likelihood Estimation Meta-Analysis of Experimentally-Induced Itch.
    The Journal of investigative dermatology, 2019, Volume: 139, Issue:10

    Topics: Adult; Allergens; Brain Mapping; Cluster Analysis; Diagnosis, Differential; Electric Stimulation; Fe

2019
Neurocutaneous disease: Cutaneous neuroanatomy and mechanisms of itch and pain.
    Journal of the American Academy of Dermatology, 2016, Volume: 74, Issue:2

    Topics: Analgesics, Opioid; Animals; Calcineurin; Histamine; Humans; Neural Pathways; Pain; Peptide Hydrolas

2016
Assessment of Itch and Pain in Animal Models and Human Subjects.
    Advances in experimental medicine and biology, 2016, Volume: 904

    Topics: Analgesics; Animals; Antipruritics; Avoidance Learning; Capsaicin; Conditioning, Classical; Emotions

2016
Migraine: where and how does the pain originate?
    Experimental brain research, 2009, Volume: 196, Issue:1

    Topics: Animals; Calcitonin Gene-Related Peptide; Headache; Histamine; Humans; Meninges; Migraine Disorders;

2009
TRP channels as novel players in the pathogenesis and therapy of itch.
    Biochimica et biophysica acta, 2007, Volume: 1772, Issue:8

    Topics: Animals; Cannabinoids; Capsaicin; Central Nervous System; Histamine; Humans; Inflammation Mediators;

2007
Biochemical mediators in pain.
    Triangle; the Sandoz journal of medical science, 1981, Volume: 20, Issue:1-2

    Topics: Antidepressive Agents; Bradykinin; Endorphins; Histamine; Humans; Nociceptors; Pain; Prostaglandins;

1981
Animal models of chronic pain: their possible validation from human experience with posterior rhizotomy and congenital analgesia (Part I of the second John J. Bonica lecture).
    Pain, 1981, Volume: 10, Issue:3

    Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Chronic Disease; Cordotomy; Disease Models, Ani

1981
Capsaicin--a literature survey.
    Critical reviews in toxicology, 1982, Volume: 10, Issue:4

    Topics: Analgesia; Animals; Blood Pressure; Body Temperature Regulation; Capsaicin; Cardiovascular System; C

1982
Inflammatory mediators of pain.
    British journal of anaesthesia, 1995, Volume: 75, Issue:2

    Topics: Adenosine Triphosphate; Cytokines; Histamine; Humans; Inflammation; Inflammation Mediators; Kinins;

1995
Itch--mediators and mechanisms.
    Journal of dermatological science, 2002, Volume: 28, Issue:2

    Topics: Antipruritics; Histamine; Humans; Models, Biological; Neurons; Nociceptors; Opioid Peptides; Pain; P

2002
The role of biogenic agents in the actions of centrally-acting analgesics.
    Progress in medicinal chemistry, 1977, Volume: 14

    Topics: Acetylcholine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bio

1977
Histamine as the chemical mediator for cutaneous pain.
    The Journal of investigative dermatology, 1977, Volume: 69, Issue:1

    Topics: Animals; Cornea; Female; Histamine; Histamine H1 Antagonists; Histamine Release; Humans; Injections,

1977
Physiology of skin.
    The Journal of investigative dermatology, 1976, Volume: 67, Issue:1

    Topics: Animals; Histamine; Humans; Lymph; Pain; Prostaglandins E; Prostaglandins F; Pruritus; Receptors, Ad

1976
Anticholinergics: do they work in peptic ulcer?
    Gastroenterology, 1975, Volume: 68, Issue:1

    Topics: Acute Disease; Antacids; Clinical Trials as Topic; Drug Therapy, Combination; Gastric Juice; Gastric

1975
Pruritus.
    International journal of dermatology, 1985, Volume: 24, Issue:10

    Topics: Cholestasis, Intrahepatic; Endopeptidases; Endorphins; Histamine; Humans; Kidney Failure, Chronic; N

1985
Chemical causes of pain and itch.
    Annual review of medicine, 1970, Volume: 21

    Topics: Arthritis; Cholestasis; Drug Eruptions; Histamine; Histamine Release; Humans; Muscular Diseases; Pai

1970
The neuropharmacology of aggression: a critical review.
    Psychological bulletin, 1974, Volume: 81, Issue:1

    Topics: Acetylcholine; Aggression; Animals; Appetitive Behavior; Behavior, Animal; Brain Chemistry; Catechol

1974
[Mechanics of actions of analgesics--especially on peripheral actions].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1973, Volume: 69, Issue:5

    Topics: Acetylcholine; Analgesics; Animals; Bradykinin; Catecholamines; Chemoreceptor Cells; Drug Synergism;

1973
A pharmacological analysis of aspirin.
    Advances in pharmacology, 1969, Volume: 7

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Blood Chemical Analysis; Bradykinin; Bronchi

1969

Trials

27 trials available for histamine and Pain

ArticleYear
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Effects of oral morphine on experimentally evoked itch and pain: a randomized, double-blind, placebo-controlled trial.
    Scandinavian journal of pain, 2023, 10-26, Volume: 23, Issue:4

    Topics: Analgesics, Opioid; Histamine; Humans; Morphine; Neurogenic Inflammation; Pain; Pruritus

2023
Gender differences in itch and pain-related sensations provoked by histamine, cowhage and capsaicin.
    Acta dermato-venereologica, 2015, Volume: 95, Issue:1

    Topics: Adult; Capsaicin; Female; Germany; Histamine; Humans; Laser-Doppler Flowmetry; Male; Mucuna; Pain; P

2015
A double-blind, randomized clinical study to determine the efficacy of benzocaine 10% on histamine-induced pruritus and UVB-light induced slight sunburn pain.
    The Journal of dermatological treatment, 2015, Volume: 26, Issue:4

    Topics: Administration, Topical; Adult; Benzocaine; Double-Blind Method; Histamine; Humans; Male; Ointments;

2015
Inducing Expectations for Health: Effects of Verbal Suggestion and Imagery on Pain, Itch, and Fatigue as Indicators of Physical Sensitivity.
    PloS one, 2015, Volume: 10, Issue:10

    Topics: Adolescent; Cold Temperature; Electrocardiography; Exercise; Fatigue; Female; Heart Rate; Histamine;

2015
Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage.
    Pain, 2009, Volume: 144, Issue:1-2

    Topics: Area Under Curve; Capsaicin; Dose-Response Relationship, Drug; Female; Histamine; Humans; Incidence;

2009
Efficiency of low-frequency ultrasound sonophoresis in skin penetration of histamine: a randomized study in humans.
    International journal of pharmaceutics, 2010, Jan-29, Volume: 385, Issue:1-2

    Topics: Administration, Cutaneous; Adult; Allergens; Drug Delivery Systems; Equipment Design; Female; Histam

2010
Induction of nocebo and placebo effects on itch and pain by verbal suggestions.
    Pain, 2011, Volume: 152, Issue:7

    Topics: Adolescent; Analysis of Variance; Double-Blind Method; Female; Histamine; Histamine Agonists; Humans

2011
Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens.
    Journal of neurophysiology, 2003, Volume: 89, Issue:5

    Topics: Acetylcholine; Adult; Bradykinin; Capsaicin; Dinoprostone; Electric Stimulation; Female; Histamine;

2003
Interaction between histamine-induced itch and experimental muscle pain.
    European journal of pain (London, England), 2004, Volume: 8, Issue:3

    Topics: Adult; Afferent Pathways; Capsaicin; Central Nervous System; Female; Histamine; Humans; Male; Models

2004
Electrically evoked itch in humans.
    Pain, 2005, Volume: 113, Issue:1-2

    Topics: Adult; Dermatitis, Atopic; Dose-Response Relationship, Radiation; Electric Stimulation; Erythema; Fe

2005
A-3665, a new short-acting opioid: a comparison with alfentanil.
    Anesthesia and analgesia, 1993, Volume: 76, Issue:4

    Topics: Adolescent; Adult; Alfentanil; Analgesics; Carbon Dioxide; Cardiovascular System; Dose-Response Rela

1993
Comparative nasal effects of bradykinin and histamine: influence on nasal airways resistance and plasma protein exudation.
    Thorax, 1993, Volume: 48, Issue:4

    Topics: Administration, Inhalation; Adult; Airway Resistance; Blood Proteins; Bradykinin; Dose-Response Rela

1993
High-potency topical corticosteroid rapidly decreases histamine-induced itch but not thermal sensation and pain in human beings.
    Journal of the American Academy of Dermatology, 1996, Volume: 35, Issue:1

    Topics: Administration, Cutaneous; Adult; Analysis of Variance; Anti-Inflammatory Agents; Clobetasol; Double

1996
A comparison of the effects of noxious and innocuous counterstimuli on experimentally induced itch and pain.
    Pain, 1996, Volume: 64, Issue:1

    Topics: Adult; Female; Histamine; Hot Temperature; Humans; Male; Mustard Plant; Pain; Physical Stimulation;

1996
Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia.
    Somatosensory & motor research, 1999, Volume: 16, Issue:4

    Topics: Adult; Analysis of Variance; Anesthetics, Local; Double-Blind Method; Forearm; Histamine; Humans; Hy

1999
Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia.
    Somatosensory & motor research, 1999, Volume: 16, Issue:4

    Topics: Adult; Capsaicin; Forearm; Histamine; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Ag

1999
Solvent for etomidate may cause pain and adverse effects.
    British journal of anaesthesia, 1999, Volume: 83, Issue:3

    Topics: Adult; Anesthetics, Intravenous; Chemistry, Pharmaceutical; Double-Blind Method; Etomidate; Fat Emul

1999
Nociceptor activation and protein extravasation induced by inflammatory mediators in human skin.
    European journal of pain (London, England), 2001, Volume: 5, Issue:1

    Topics: Adult; Axons; Blood Proteins; Bradykinin; Erythema; Female; Free Radical Scavengers; Histamine; Huma

2001
Experimental itch in sodium lauryl sulphate-inflamed and normal skin in humans: a randomized, double-blind, placebo-controlled study of histamine and other inducers of itch.
    The British journal of dermatology, 2002, Volume: 146, Issue:5

    Topics: Adult; Dermatitis, Contact; Double-Blind Method; Edema; Erythema; Female; Histamine; Humans; Injecti

2002
Topically applied aspirin decreases histamine-induced wheal and flare reactions in normal and SLS-inflamed skin, but does not decrease itch. A randomized, double-blind and placebo-controlled human study.
    Acta dermato-venereologica, 2002, Volume: 82, Issue:1

    Topics: Administration, Topical; Adult; Analysis of Variance; Aspirin; Dermatitis, Irritant; Double-Blind Me

2002
Anticholinergics: do they work in peptic ulcer?
    Gastroenterology, 1975, Volume: 68, Issue:1

    Topics: Acute Disease; Antacids; Clinical Trials as Topic; Drug Therapy, Combination; Gastric Juice; Gastric

1975
Local anaesthetic creams and intradermal skin tests.
    Lancet (London, England), 1992, May-30, Volume: 339, Issue:8805

    Topics: Anesthetics, Local; Drug Combinations; Histamine; Humans; Injections, Intradermal; Lidocaine; Lidoca

1992
A quantitative comparison of the effect of local analgesics on argon laser induced cutaneous pain and on histamine induced wheal, flare and itch.
    Acta dermato-venereologica, 1990, Volume: 70, Issue:2

    Topics: Administration, Topical; Adult; Anesthetics, Local; Drug Combinations; Emollients; Female; Histamine

1990
The effect of hypnotically induced analgesia on flare reaction of the cutaneous histamine prick test.
    Archives of dermatological research, 1990, Volume: 282, Issue:8

    Topics: Adult; Analgesia; Double-Blind Method; Electroencephalography; Female; Histamine; Humans; Hypersensi

1990
Effect of antihistamines on argon laser-induced cutaneous sensory and pain thresholds and on histamine-induced wheal and flare.
    Skin pharmacology : the official journal of the Skin Pharmacology Society, 1989, Volume: 2, Issue:4

    Topics: Adult; Analgesics; Histamine; Histamine Antagonists; Humans; Lasers; Pain; Photic Stimulation; Senso

1989
Prostaglandins, aspirin-like drugs and analgesia.
    Nature: New biology, 1972, Dec-13, Volume: 240, Issue:102

    Topics: Acetylcholine; Analgesia; Arachidonic Acids; Aspirin; Bradykinin; Clinical Trials as Topic; Erythema

1972

Other Studies

193 other studies available for histamine and Pain

ArticleYear
Clinical and histological characterization of transient dermal pain triggered by sweating stimuli.
    Allergology international : official journal of the Japanese Society of Allergology, 2022, Volume: 71, Issue:3

    Topics: Histamine; Humans; Hypohidrosis; Male; Pain; Retrospective Studies; Sweating; Urticaria

2022
Punctate Administration of Ficin as a human and animal model of non-histaminergic itch.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2022, Volume: 36, Issue:8

    Topics: Animals; Disease Models, Animal; Ficain; Histamine; Humans; Mice; Pain; Pruritus

2022
Topical Capsaicin in Poly(lactic-co-glycolic)acid (PLGA) Nanoparticles Decreases Acute Itch and Heat Pain.
    International journal of molecular sciences, 2022, May-09, Volume: 23, Issue:9

    Topics: Animals; beta-Alanine; Capsaicin; Glycols; Histamine; Hot Temperature; Humans; Mice; Nanoparticles;

2022
Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar
    Frontiers in immunology, 2022, Volume: 13

    Topics: Animals; Histamine; Humans; Lepidoptera; Manduca; Nerve Tissue Proteins; Pain; Pruritus; Receptors,

2022
Evaluation of anti-inflammatory and analgesic effects of Hertia intermedia (Boiss.) Kuntze extract.
    Pakistan journal of pharmaceutical sciences, 2022, Volume: 35, Issue:4(Special)

    Topics: Acetates; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Asteraceae; Carrageenan; Edema

2022
Histamine H1 receptor antagonist attenuates catecholamine surge and organ injury after severe burns.
    Frontiers in endocrinology, 2023, Volume: 14

    Topics: Animals; Cetirizine; Fentanyl; Histamine; Histamine H1 Antagonists; Midazolam; Pain; Promethazine; R

2023
Histamine and its H 1 receptors in the ventral pallidum mediate formalin-induced pain-related behaviors through this region and spinal cord opioid receptors.
    Behavioural pharmacology, 2023, 12-01, Volume: 34, Issue:8

    Topics: Animals; Basal Forebrain; Formaldehyde; Histamine; Histamine Agonists; Naloxone; Pain; Receptors, Op

2023
Cowhage-induced itch scores and the current perception threshold in assessing sensitive skin: An observational laboratory study.
    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2023, Volume: 29, Issue:6

    Topics: Histamine; Humans; Pain; Perception; Pruritus; Sensation; Skin

2023
Microglia are involved in regulating histamine-dependent and non-dependent itch transmissions with distinguished signal pathways.
    Glia, 2023, Volume: 71, Issue:11

    Topics: Animals; Chloroquine; Histamine; Mice; Mice, Transgenic; Microglia; Pain; Pruritus; Signal Transduct

2023
Crisaborole Inhibits Itch and Pain by Preventing Neutrophil Infiltration in a Mouse Model of Atopic Dermatitis.
    Acta dermato-venereologica, 2023, 08-22, Volume: 103

    Topics: Animals; Calcium; Capsaicin; Chloroquine; Dermatitis, Atopic; Disease Models, Animal; Histamine; Neu

2023
Calcium imaging of primary canine sensory neurons: Small-diameter neurons responsive to pruritogens and algogens.
    Brain and behavior, 2019, Volume: 9, Issue:12

    Topics: Animals; Cadaver; Calcium Radioisotopes; Capsaicin; Cattle; Cells, Cultured; Chloroquine; Dogs; Gang

2019
Hippocalcin-like 4, a neural calcium sensor, has a limited contribution to pain and itch processing.
    PloS one, 2020, Volume: 15, Issue:2

    Topics: Animals; Behavior Rating Scale; Behavior, Animal; Chloroquine; Gene Knockout Techniques; Histamine;

2020
Exploration of sensory and spinal neurons expressing gastrin-releasing peptide in itch and pain related behaviors.
    Nature communications, 2020, 03-13, Volume: 11, Issue:1

    Topics: Animals; Disease Models, Animal; Gastrin-Releasing Peptide; Gene Knockout Techniques; Histamine; Mic

2020
Early radiation-induced oral pain signaling responses are reduced with pentoxifylline treatment.
    Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association, 2021, Volume: 62, Issue:2

    Topics: Animals; Capsaicin; Histamine; Mice; Pain; Pentoxifylline; Pilot Projects; Prospective Studies; Radi

2021
The role of pruriceptors in enhancing sensitivity to pruritogens in a murine chronic compression model of dorsal root ganglion.
    Molecular brain, 2021, 01-19, Volume: 14, Issue:1

    Topics: Animals; Calcium; Capsaicin; Cattle; Chronic Disease; Disease Models, Animal; Ganglia, Spinal; Hista

2021
Pharmacological studies on aqueous extract of Launaea arborescens from southwest Algeria.
    Journal of ethnopharmacology, 2021, Jul-15, Volume: 275

    Topics: Algeria; Analgesics; Animals; Anti-Inflammatory Agents; Asteraceae; Behavior, Animal; Capsaicin; Ede

2021
Sulfonamides as Selective Na
    Journal of medicinal chemistry, 2017, 07-27, Volume: 60, Issue:14

    Topics: Analgesics; Animals; Capsaicin; Cell Line; Dogs; Histamine; Mice, Inbred C57BL; Molecular Docking Si

2017
UVB- and NGF-induced cutaneous sensitization in humans selectively augments cowhage- and histamine-induced pain and evokes mechanical hyperknesis.
    Experimental dermatology, 2018, Volume: 27, Issue:3

    Topics: Adult; Female; Histamine; Humans; Hyperalgesia; Male; Mucuna; Nerve Growth Factor; Nociception; Pain

2018
Potamotrygon motoro stingray venom induces both neurogenic and inflammatory pain behavior in rodents.
    Toxicon : official journal of the International Society on Toxinology, 2018, Volume: 150

    Topics: Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Fish Venoms; Histamine; Hyperalgesia; In

2018
Responses of thalamic neurons to itch- and pain-producing stimuli in rats.
    Journal of neurophysiology, 2018, 09-01, Volume: 120, Issue:3

    Topics: Action Potentials; Animals; Antipruritics; beta-Alanine; Capsaicin; Chloroquine; Histamine; Injectio

2018
Enhanced histamine-induced itch in diacylglycerol kinase iota knockout mice.
    PloS one, 2019, Volume: 14, Issue:6

    Topics: Animals; Behavior, Animal; Calcium; Diacylglycerol Kinase; Disease Models, Animal; Female; Ganglia,

2019
Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Apr-03, Volume: 33, Issue:14

    Topics: Action Potentials; Analgesics, Opioid; Animals; Antirheumatic Agents; Chloroquine; Electric Stimulat

2013
Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1.
    The journal of pain, 2013, Volume: 14, Issue:6

    Topics: Animals; Capsaicin; Chloroquine; Constriction; Disease Models, Animal; Functional Laterality; Histam

2013
Histamine produces opposing effects to serotonin in the knee joint of rats.
    The journal of pain, 2013, Volume: 14, Issue:8

    Topics: Analysis of Variance; Animals; Cetirizine; Edema; Evans Blue; Formaldehyde; Histamine; Histamine H1

2013
Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons.
    Nature neuroscience, 2013, Volume: 16, Issue:7

    Topics: Action Potentials; Anesthetics, Local; Animals; Antipruritics; Antirheumatic Agents; Behavior, Anima

2013
Sensitivity to itch and pain in patients with psoriasis and rheumatoid arthritis.
    Experimental dermatology, 2013, Volume: 22, Issue:8

    Topics: Adult; Aged; Arthritis, Rheumatoid; Cold Temperature; Female; Histamine; Humans; Inflammation; Middl

2013
Polysaccharide isolated from Agardhiella ramosissima: chemical structure and anti-inflammation activity.
    Carbohydrate polymers, 2014, Volume: 99

    Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cell Movement; Dextrans; Edema; Galactose; Hindlimb;

2014
Anti-inflammatory and antinociceptive effects of Sterculia striata A. St.-Hil. & Naudin (Malvaceae) in rodents.
    Journal of medicinal food, 2014, Volume: 17, Issue:6

    Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Carrageenan; Dextrans; Edema;

2014
Behavioral model of itch, alloknesis, pain and allodynia in the lower hindlimb and correlative responses of lumbar dorsal horn neurons in the mouse.
    Neuroscience, 2014, Apr-25, Volume: 266

    Topics: Action Potentials; Animals; Capsaicin; Disease Models, Animal; Electrophysiology; Hindlimb; Histamin

2014
Peripheral antinociception and anti-inflammatory effects of sulphated polysaccharides from the alga Caulerpa mexicana.
    Basic & clinical pharmacology & toxicology, 2014, Volume: 115, Issue:4

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Caulerpa; Dextrans; Disease Models, Anim

2014
Hemokinin-1 mediates pruriceptive processing in the rat spinal cord.
    Neuroscience, 2014, Sep-26, Volume: 277

    Topics: Animals; Disease Models, Animal; Formaldehyde; Histamine; Immunohistochemistry; Male; Nociception; P

2014
Mechano-sensitive nociceptors are required to detect heat pain thresholds and cowhage itch in human skin.
    European journal of pain (London, England), 2016, Volume: 20, Issue:2

    Topics: Adult; Histamine; Hot Temperature; Humans; Iontophoresis; Male; Mechanoreceptors; Nociceptors; Pain;

2016
Effects of microinjection of histamine into the anterior cingulate cortex on pain-related behaviors induced by formalin in rats.
    Pharmacological reports : PR, 2015, Volume: 67, Issue:3

    Topics: Animals; Formaldehyde; Gyrus Cinguli; Histamine; Male; Microinjections; Pain; Pain Measurement; Rats

2015
[Vulvar oedema revealing systemic mastocytosis].
    Annales de dermatologie et de venereologie, 2015, Volume: 142, Issue:11

    Topics: Adult; Biomarkers; Bone Diseases; Diarrhea; Edema; Female; Histamine; Humans; Immunosuppressive Agen

2015
The Maddening Sensation of Itch.
    Scientific American, 2016, Volume: 314, Issue:5

    Topics: Animals; Histamine; Histamine Antagonists; Humans; Neurons; Pain; Peptide Hydrolases; Pruritus; Rece

2016
Phytochemical screening, safety evaluation, anti-inflammatory and analgesic studies of the leaf extracts of Sterculia tragacantha.
    Journal of complementary & integrative medicine, 2016, Sep-01, Volume: 13, Issue:3

    Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Female; Flavonoi

2016
Conditioning pain stimulation does not affect itch induced by intra-epidermal histamine pricks but aggravates neurogenic inflammation in healthy volunteers.
    Somatosensory & motor research, 2016, Volume: 33, Issue:1

    Topics: Adult; Female; Galvanic Skin Response; Healthy Volunteers; Heart Rate; Histamine; Histamine Agonists

2016
Analgesic and anti-inflammatory actions on bradykinin route of a polysulfated fraction from alga Ulva lactuca.
    International journal of biological macromolecules, 2016, Volume: 92

    Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Bradykinin; Carrageenan; Chemical Fracti

2016
TRPA1, substance P, histamine and 5-hydroxytryptamine interact in an interdependent way to induce nociception.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2017, Volume: 66, Issue:4

    Topics: Acetanilides; Animals; Histamine; Histamine H1 Antagonists; Isothiocyanates; Male; Oligonucleotides,

2017
A novel zebrafish-based model of nociception.
    Physiology & behavior, 2017, 05-15, Volume: 174

    Topics: Acetic Acid; Acrolein; Analgesics, Opioid; Animals; Antineoplastic Agents, Phytogenic; Disease Model

2017
Separate peripheral pathways for pruritus in man.
    Journal of neurophysiology, 2008, Volume: 100, Issue:4

    Topics: Capsaicin; Electric Stimulation; Electrophysiology; Histamine; Hot Temperature; Humans; Mechanorecep

2008
Residual spinothalamic tract pathways predict development of central pain after spinal cord injury.
    Brain : a journal of neurology, 2008, Volume: 131, Issue:Pt 9

    Topics: Adult; Capsaicin; Cold Temperature; Female; Histamine; Hot Temperature; Humans; Male; Menthol; Middl

2008
Behavioral differentiation between itch and pain in mouse.
    Pain, 2008, Oct-31, Volume: 139, Issue:3

    Topics: Animals; Behavior, Animal; Capsaicin; Cheek; Dose-Response Relationship, Drug; Forelimb; Hindlimb; H

2008
TRPA1-mediated nociception.
    Neuroscience, 2008, Aug-13, Volume: 155, Issue:2

    Topics: Animals; Formaldehyde; Histamine; Mice; Nociceptors; Pain; Transient Receptor Potential Channels; TR

2008
Cellular basis of itch sensation.
    Science (New York, N.Y.), 2009, Sep-18, Volume: 325, Issue:5947

    Topics: Afferent Pathways; Animals; Behavior, Animal; Bombesin; Chronic Disease; Histamine; Humans; Male; Mi

2009
Possible involvement of histamine, dopamine, and noradrenalin in the periaqueductal gray in electroacupuncture pain relief.
    Brain research, 2010, Jan-08, Volume: 1306

    Topics: Animals; Dopamine; Electroacupuncture; Formaldehyde; Histamine; Male; Microdialysis; Neurons; Neurot

2010
Histamine potentiates acid-induced responses mediating transient receptor potential V1 in mouse primary sensory neurons.
    Neuroscience, 2010, Mar-10, Volume: 166, Issue:1

    Topics: Acids; Action Potentials; Animals; Calcium Signaling; Enzyme Inhibitors; Ganglia, Spinal; Histamine;

2010
Cryotherapy decreases histamine levels in the blood of patients with rheumatoid arthritis.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2010, Volume: 59 Suppl 2

    Topics: Arthritis, Rheumatoid; beta-N-Acetylhexosaminidases; Cartilage; Cryotherapy; Enzyme-Linked Immunosor

2010
Role of attentional focus on bodily sensations in sensitivity to itch and pain.
    Acta dermato-venereologica, 2010, Volume: 90, Issue:1

    Topics: Administration, Topical; Adult; Attention; Capsaicin; Cold Temperature; Electric Stimulation; Female

2010
Inhibition of brain [(3)H]cimetidine binding by improgan-like antinociceptive drugs.
    European journal of pharmacology, 2010, Apr-25, Volume: 632, Issue:1-3

    Topics: Analgesics; Animals; Binding Sites; Brain; Cimetidine; Dose-Response Relationship, Drug; Histamine;

2010
Heterotopic pruritic conditioning and itch--analogous to DNIC in pain?
    Pain, 2010, Volume: 149, Issue:2

    Topics: Adult; Aged; Central Nervous System; Chronic Disease; Conditioning, Psychological; Electric Stimulat

2010
[Acupoint-injection of histamine induced analgesic effect in acute adjuvant-induced-arthritis rats].
    Zhen ci yan jiu = Acupuncture research, 2010, Volume: 35, Issue:2

    Topics: Acupuncture Points; Acute Disease; Analgesics; Animals; Arthritis; Disease Models, Animal; Freund's

2010
VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch.
    Neuron, 2010, Nov-04, Volume: 68, Issue:3

    Topics: Animals; Behavior, Animal; Female; Histamine; Humans; Immunohistochemistry; In Situ Hybridization; M

2010
Differential itch- and pain-related behavioral responses and µ-opoid modulation in mice.
    Acta dermato-venereologica, 2010, Volume: 90, Issue:6

    Topics: Analgesics, Opioid; Animals; Antigens, Plant; Behavior, Animal; Capsaicin; Disease Models, Animal; D

2010
Involvement of glial cells in the nociceptive behaviors induced by a high-dose of histamine administered intrathecally.
    European journal of pharmacology, 2011, Feb-25, Volume: 653, Issue:1-3

    Topics: Agmatine; Animals; Behavior, Animal; Blotting, Western; Dizocilpine Maleate; Dose-Response Relations

2011
Partial involvement of NMDA receptors and glial cells in the nociceptive behaviors induced by intrathecally administered histamine.
    Neuroscience letters, 2011, May-16, Volume: 495, Issue:2

    Topics: Animals; Histamine; Injections, Spinal; Male; Mice; Neuroglia; Neurotransmitter Agents; Pain; Pain P

2011
Role of TRPV1 in nociception and edema induced by monosodium urate crystals in rats.
    Pain, 2011, Volume: 152, Issue:8

    Topics: Acrylamides; Anilides; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Antioxidants; Bridged B

2011
Interaction of histamine and calcitonin gene-related peptide in the formalin induced pain perception in rats.
    Biomedical research (Tokyo, Japan), 2011, Volume: 32, Issue:3

    Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antag

2011
Protective role of the triterpenoid-enriched extract of Trichosanthes dioica root against experimentally induced pain and inflammation in rodents.
    Natural product research, 2012, Volume: 26, Issue:24

    Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dose-Response Relationship,

2012
A report on anti-oedemogenic activity of Byttneria herbacea roots--possible involvement of histamine receptor (type I).
    Journal of ethnopharmacology, 2012, Mar-27, Volume: 140, Issue:2

    Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Capillary Permeability; Carrageenan; Dose-Respon

2012
Role of induced negative and positive emotions in sensitivity to itch and pain in women.
    The British journal of dermatology, 2012, Volume: 167, Issue:2

    Topics: Analysis of Variance; Cold Temperature; Electric Stimulation; Emotions; Female; Histamine; Histamine

2012
Endothelin-1 induces itch and pain in the mouse cheek model.
    Life sciences, 2012, Oct-15, Volume: 91, Issue:13-14

    Topics: Animals; Behavior, Animal; Capsaicin; Cheek; Dose-Response Relationship, Drug; Endothelin A Receptor

2012
Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant.
    BMC complementary and alternative medicine, 2012, May-02, Volume: 12

    Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Behavior, A

2012
CGRPα-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch.
    PloS one, 2012, Volume: 7, Issue:5

    Topics: Animals; Brain; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Chloroquine; Female; Ga

2012
Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice.
    Pharmacological research, 2002, Volume: 45, Issue:6

    Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dantrolene;

2002
Combined action of vasoactive amines and bradykinin mediates allergen-evoked thermal hyperalgesia in rats.
    European journal of pharmacology, 2003, Feb-21, Volume: 462, Issue:1-3

    Topics: Allergens; Animals; Bradykinin; Bradykinin Receptor Antagonists; Cyproheptadine; Dinitrophenols; Dos

2003
Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats.
    Pain, 2003, Volume: 102, Issue:1-2

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Dextromethorphan; Dose-Response

2003
Anti-inflammatory and analgesic activity of Bouchea fluminensis.
    Fitoterapia, 2003, Volume: 74, Issue:4

    Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dose-

2003
Mechanism of anti-nociceptive effects of Asarum sieboldii Miq. radix: potential role of bradykinin, histamine and opioid receptor-mediated pathways.
    Journal of ethnopharmacology, 2003, Volume: 88, Issue:1

    Topics: Analgesics, Non-Narcotic; Animals; Asarum; Bradykinin; Carrageenan; Edema; Guinea Pigs; Histamine; I

2003
Analgesic and antiinflammatory activity of antibodies to histamine under experimental conditions.
    Bulletin of experimental biology and medicine, 2003, Volume: 135 Suppl 7

    Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antibodies; Histamine; Mice; Pain; Rats

2003
[Thermoanalgesic properties of cortisone and ACTH; modification of pain reaction by histamine bichlorhydrate, cooling and formol].
    Archives internationales de pharmacodynamie et de therapie, 1952, Volume: 90, Issue:2-3

    Topics: Adrenocorticotropic Hormone; Body Temperature; Cold Temperature; Cortisone; Formaldehyde; Histamine;

1952
Chemical excitants of cutaneous pain in man.
    Acta neurovegetativa, 1953, Volume: 7, Issue:1-4

    Topics: Acetylcholine; Histamine; Histamine Agents; Musculoskeletal Diseases; Pain

1953
[Phenomenon of pain reactivation following cutaneous and muscular introduction of histamine].
    Rassegna di neurologia vegetativa, 1953, Volume: 10, Issue:1-2

    Topics: Administration, Cutaneous; Histamine; Humans; Muscles; Pain

1953
[Effect of histamine on pain threshold of the skin].
    Rassegna di neurologia vegetativa, 1953, Volume: 10, Issue:1-2

    Topics: Histamine; Histamine Agents; Humans; Pain; Pain Threshold; Skin

1953
The influence of acetylcholine, curarine and related substance on the threshold for chemical pain stimuli.
    Acta physiologica Scandinavica, 1953, Nov-17, Volume: 29, Issue:4

    Topics: Acetylcholine; Curare; Histamine; Histamine Agents; Humans; Muscle Relaxants, Central; Pain; Potassi

1953
Pharyngeal and laryngeal phenomena of vascular origin.
    Transactions of the ... annual meeting of the American Laryngological Association. American Laryngological Association. Annual Meeting, 1953, Volume: 74

    Topics: Histamine; Humans; Laryngeal Diseases; Larynx; Pain; Pharynx

1953
The effect of histamine analogues on cutaneous pain.
    Archives internationales de pharmacodynamie et de therapie, 1953, Nov-01, Volume: 96, Issue:2

    Topics: Histamine; Humans; Inorganic Chemicals; Musculoskeletal Diseases; Pain

1953
On the mechanism of ulcer pain.
    The American journal of digestive diseases, 1954, Volume: 21, Issue:7

    Topics: Histamine; Histamine Agents; Pain; Peptic Ulcer; Ulcer

1954
[Effect of pain stimulus on histamine in blood].
    Orvosi hetilap, 1955, Apr-10, Volume: 96, Issue:15

    Topics: Blood; Histamine; Humans; Pain

1955
[Effect of pain stimulus on blood histamine].
    Acta medica Academiae Scientiarum Hungaricae, 1955, Volume: 8, Issue:2

    Topics: Biological Phenomena; Blood; Histamine; Humans; Pain; Physiological Phenomena

1955
[Physiology and clinical aspects of the pain sensation].
    Wiener klinische Wochenschrift, 1956, Dec-21, Volume: 68, Issue:51

    Topics: Histamine; Humans; Pain; Skin Physiological Phenomena

1956
[Role of histamine in the transmission of pain].
    Archives internationales de pharmacodynamie et de therapie, 1956, Dec-01, Volume: 108, Issue:3-4

    Topics: Histamine; Humans; Pain

1956
[Transmission of pain sensitivity in human skin].
    Archives internationales de pharmacodynamie et de therapie, 1957, Feb-01, Volume: 109, Issue:3-4

    Topics: Histamine; Humans; Pain; Pain Threshold; Skin; Skin Physiological Phenomena

1957
[Significance of histamine in reflex reactions of the organism in multiple pain stimulation].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1957, Volume: 43, Issue:3

    Topics: Heart; Histamine; Histamine Agents; Nervous System Physiological Phenomena; Pain; Reflex

1957
Histamine release and pain production by xanthosine and related compounds.
    British journal of pharmacology and chemotherapy, 1957, Volume: 12, Issue:3

    Topics: Adenosine; Animals; Cats; Female; Guanosine; Guinea Pigs; Histamine; Histamine Release; Humans; Ileu

1957
[Treatment of various diseases and alleviation of pain by bettering the circulation with intracutaneous medication].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1958, Feb-15, Volume: 13, Issue:4

    Topics: Biological Phenomena; Blood Circulation; Blood Proteins; Heparin; Histamine; Humans; Injections, Int

1958
Effect of chlorpromazine on antidiuretic response to noxious stimuli.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1958, Volume: 99, Issue:1

    Topics: Chlorpromazine; Diuresis; Histamine; Histamine Agents; Nicotine; Pain

1958
[Inflammation & pain in histamine-free skin].
    Acta neurovegetativa, 1958, Volume: 18, Issue:1-4

    Topics: Histamine; Inflammation; Pain; Skin

1958
[CONTRIBUTION TO THE QUESTION OF PAIN OR HYPERALGESIA RELEASING SUBSTANCES].
    Acta neurovegetativa, 1963, Jul-22, Volume: 25

    Topics: Anti-Allergic Agents; Contusions; Histamine; Histamine H1 Antagonists; Histamine Release; Humans; Hy

1963
NOCICEPTIVE RESPONSES OF GUINEA-PIGS TO INTRADERMAL INJECTIONS OF BRADYKININ AND KALLIDIN-10.
    British journal of pharmacology and chemotherapy, 1963, Volume: 21

    Topics: Acetylcholine; Animals; Bradykinin; Guinea Pigs; Histamine; Humans; Injections, Intradermal; Injecti

1963
[PHARMACODYNAMIC TESTS IN THE DIAGNOSIS OF ULCEROUS DISEASE. I. VALUE OF SOME DIAGNOSTIC TESTS TO INDUCE ULCEROUS PAINS BY MOTOR AND SECRETORY FUNCTIONAL OVERLOAD].
    Medicina interna, 1963, Volume: 15

    Topics: Biological Transport; Diagnosis; Diagnostic Tests, Routine; Histamine; Hydrochloric Acid; Insulin; P

1963
[SOME PROBLEMS CONCERNING THE PRE-ULCEROUS PHASE OF ULCEROUS DISEASE].
    Medicina interna, 1963, Volume: 15

    Topics: Diagnosis; Dyspepsia; Gastric Acidity Determination; Gastrointestinal Hemorrhage; Hemorrhage; Histam

1963
[A COMMENTARY ON ARTHRALGIA].
    Nihon Ishikai zasshi. Journal of the Japan Medical Association, 1963, Nov-01, Volume: 50

    Topics: Acetylcholine; Arthralgia; Arthritis; Autonomic Nervous System; Histamine; Humans; Joint Diseases; N

1963
Observations on histamine-induced pruritus and pain.
    British journal of pharmacology and chemotherapy, 1955, Volume: 10, Issue:2

    Topics: Histamine; Pain; Pruritus

1955
[Analysis of the behavior of cutaneous pain following the intradermal injection of histamine, acetylcholine, adrenaline and 5-hydroxytryptamine].
    Rassegna di neurologia vegetativa, 1960, Jun-30, Volume: 15

    Topics: Acetylcholine; Epinephrine; Histamine; Humans; Injections, Intradermal; Musculoskeletal Diseases; Pa

1960
Painful stimuli evoke itch in patients with chronic pruritus: central sensitization for itch.
    Neurology, 2004, Jan-27, Volume: 62, Issue:2

    Topics: Adult; Dermatitis, Atopic; Electric Stimulation; Female; Histamine; Hot Temperature; Humans; Male; M

2004
Intra-arterial histamine in treatment of claudication and rest pain.
    British medical journal, 1950, Nov-11, Volume: 2, Issue:4688

    Topics: Arteriosclerosis; Histamine; Humans; Intermittent Claudication; Pain

1950
Responses of the abnormal arterial circulation to various stimuli, as studied by the use of radioactive sodium. II. Intraarterial histamine, papaverine, aminophylline and adrenaline; sympathectomy and etamon; pain.
    Annals of internal medicine, 1951, Volume: 34, Issue:2

    Topics: Aminophylline; Arteries; Blood Vessels; Epinephrine; Histamine; Humans; Pain; Papaverine; Sodium; So

1951
[On the effect of histamin and antihistamin on Head's zone; a contribution on pathophysiology of referred pain and of the functional shifts].
    Deutsche Zeitschrift fur Nervenheilkunde, 1952, Volume: 167, Issue:4

    Topics: Anti-Allergic Agents; Head; Histamine; Histamine Agents; Histamine H1 Antagonists; Humans; Pain; Pai

1952
Histamine as possible chemical mediator for cutaneous pain; painful responses on intradermal injection of perfusates from stimulated human skin.
    Journal of applied physiology, 1949, Volume: 2, Issue:6

    Topics: Histamine; Humans; Injections, Intradermal; Musculoskeletal Diseases; Pain; Pain Management

1949
Histamine as possible chemical mediator for cutaneous pain. Dual pain response to histamine.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1950, Volume: 74, Issue:1

    Topics: Histamine; Humans; Musculoskeletal Diseases; Pain; Skin

1950
[Action of phenergan syrup on gastric pains].
    Lyon medical, 1950, Jun-11, Volume: 183, Issue:24

    Topics: Abdominal Pain; Histamine; Humans; Pain; Promethazine; Stomach

1950
Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: a study in histidine decarboxylase gene knockout mice.
    European journal of pharmacology, 2005, Oct-17, Volume: 522, Issue:1-3

    Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Behavior, Animal; Capsaicin; Excitatory Amino Acid

2005
Noxious heat and scratching decrease histamine-induced itch and skin blood flow.
    The Journal of investigative dermatology, 2005, Volume: 125, Issue:6

    Topics: Cold Temperature; Dermatitis, Atopic; Female; Histamine; Hot Temperature; Humans; Male; Pain; Region

2005
Bradykinin is a potent pruritogen in atopic dermatitis: a switch from pain to itch.
    Pain, 2006, Dec-15, Volume: 126, Issue:1-3

    Topics: Adult; Bradykinin; Cross-Over Studies; Dermatitis, Atopic; Female; Histamine; Histamine H1 Antagonis

2006
Antinociceptive and anti-inflammatory effects of Thespesia populnea bark extract.
    Journal of ethnopharmacology, 2007, Jan-19, Volume: 109, Issue:2

    Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis;

2007
Anti-inflammatory and antinociceptive activities of extract, fractions and populnoic acid from bark wood of Austroplenckia populnea.
    Journal of ethnopharmacology, 2007, Feb-12, Volume: 109, Issue:3

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Brazil; Capillary Permeability; Carrageenan; Celastra

2007
[Effect of nociceptin on histamine and serotonin release in the central nervous system].
    Acta pharmaceutica Hungarica, 2006, Volume: 76, Issue:3

    Topics: Animals; Disease Models, Animal; Hippocampus; Histamine; Histamine Release; Hypothalamus; Pain; Rats

2006
Neural correlates of perceptual difference between itching and pain: a human fMRI study.
    NeuroImage, 2007, Jul-01, Volume: 36, Issue:3

    Topics: Adult; Cold Temperature; Data Interpretation, Statistical; Gyrus Cinguli; Histamine; Humans; Image P

2007
Indirect mechanism of histamine-induced nociception in temporomandibular joint of rats.
    Life sciences, 2007, Aug-09, Volume: 81, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Dose-Response Relationship, Drug

2007
Itch induced by a novel method leads to limbic deactivations a functional MRI study.
    Journal of neurophysiology, 2007, Volume: 98, Issue:4

    Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Brain; Codeine; Data Interpretation, Statistical; Fem

2007
Role of histaminergic neurons in hypnotic modulation of brain processing of visceral perception.
    Neurogastroenterology and motility, 2007, Volume: 19, Issue:10

    Topics: Adult; Brain; Chlorpheniramine; Electric Stimulation; Electroencephalography; Evoked Potentials, Som

2007
Heritability of responses to painful stimuli in women: a classical twin study.
    Brain : a journal of neurology, 2007, Volume: 130, Issue:Pt 11

    Topics: Acids; Adenosine Triphosphate; Adult; Aged; Burns; Burns, Chemical; Female; Histamine; Hot Temperatu

2007
Repetitive scratching and noxious heat do not inhibit histamine-induced itch in atopic dermatitis.
    The British journal of dermatology, 2008, Volume: 158, Issue:1

    Topics: Adult; Dermatitis, Atopic; Female; Histamine; Hot Temperature; Humans; Iontophoresis; Male; Middle A

2008
Intrathecal high-dose histamine induces spinally-mediated nociceptive behavioral responses through a polyamine site of NMDA receptors.
    European journal of pharmacology, 2008, Feb-26, Volume: 581, Issue:1-2

    Topics: Animals; Excitatory Amino Acid Antagonists; Histamine; Injections, Spinal; Male; Mice; Mice, Inbred

2008
Anti-inflammatory and anti-nociceptive activities of Fumaria indica whole plant extract in experimental animals.
    Acta pharmaceutica (Zagreb, Croatia), 2007, Volume: 57, Issue:4

    Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cotto

2007
Mast cell-derived histamine mediates cystitis pain.
    PloS one, 2008, May-07, Volume: 3, Issue:5

    Topics: Animals; Cystitis; Herpesvirus 1, Suid; Histamine; Mast Cells; Mice; Pain; Pelvis; Pseudorabies; Rec

2008
The chemistry of pain production.
    Proceedings of the Royal Society of Medicine, 1967, Volume: 60, Issue:4

    Topics: Acetylcholine; Bradykinin; Histamine; Humans; Migraine Disorders; Pain; Potassium; Serotonin; Urtica

1967
Anti-inflammatory evaluation of cryogenine.
    Journal of pharmaceutical sciences, 1967, Volume: 56, Issue:11

    Topics: Analgesics; Animals; Bradykinin; Carrageenan; Drinking; Drug Antagonism; Edema; Female; Fever; Guine

1967
Responses of skin blood vessels to bradykinin, histamine and 5-hydroxytryptamine.
    The Journal of physiology, 1967, Volume: 193, Issue:2

    Topics: Adult; Arteries; Blood Vessels; Bradykinin; Chlorpheniramine; Female; Histamine; Humans; Hydrocortis

1967
On the etiopathogenesis of migraine: a possible link between the amines and endorphin hypotheses.
    Advances in neurology, 1982, Volume: 33

    Topics: Adult; Clonidine; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Histamine; Huma

1982
Dependence of histamine-evoked nociception on prostaglandin release.
    Agents and actions, 1981, Volume: 11, Issue:6-7

    Topics: Animals; Drug Interactions; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Indometha

1981
[Reactivation of the algogenic component in experimental inflammation induced by histamine administration].
    Minerva medica, 1983, Apr-14, Volume: 74, Issue:16

    Topics: Dermatitis, Contact; Dry Ice; Histamine; Histamine Release; Humans; Injections, Intravenous; Pain

1983
Intrinsic mechanisms of pain inhibition: activation by stress.
    Science (New York, N.Y.), 1984, Dec-14, Volume: 226, Issue:4680

    Topics: Adaptation, Physiological; Adrenalectomy; Anesthesia; Animals; Brain Stem; Conditioning, Psychologic

1984
C nociceptor activity in human nerve during painful and non painful skin stimulation.
    Journal of neurology, neurosurgery, and psychiatry, 1981, Volume: 44, Issue:7

    Topics: Adult; Histamine; Hot Temperature; Humans; Methylene Chloride; Nerve Fibers; Neural Conduction; Noci

1981
Scratching behavior induced by pruritogenic but not algesiogenic agents in mice.
    European journal of pharmacology, 1995, Mar-14, Volume: 275, Issue:3

    Topics: Animals; Behavior, Animal; Capsaicin; Formaldehyde; Histamine; Male; Mice; p-Methoxy-N-methylpheneth

1995
Effects of topical capsaicin in seasonal allergic rhinitis.
    Thorax, 1995, Volume: 50, Issue:3

    Topics: Administration, Topical; Adult; Allergens; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid

1995
Importance of histamine H2 receptors in restraint-morphine interactions.
    Life sciences, 1995, Volume: 57, Issue:13

    Topics: Analysis of Variance; Animals; Benzothiazoles; Histamine; Histamine H2 Antagonists; Male; Morphine;

1995
Small fibre function in primary autonomic failure.
    Journal of neurology, 1993, Volume: 241, Issue:2

    Topics: Afferent Pathways; Autonomic Nervous System; Axons; Female; Histamine; Humans; Hypotension, Orthosta

1993
Postherpetic neuralgia. Are C-nociceptors involved in signalling and maintenance of tactile allodynia?
    Brain : a journal of neurology, 1993, Volume: 116 ( Pt 6)

    Topics: Aged; Body Temperature; Female; Herpes Zoster; Histamine; Humans; Iontophoresis; Male; Middle Aged;

1993
The ability of humans to localise noxious stimuli.
    Neuroscience letters, 1993, Feb-19, Volume: 150, Issue:2

    Topics: Adult; Brain Mapping; Female; Histamine; Hot Temperature; Humans; Male; Middle Aged; Mustard Plant;

1993
Conditioning of histamine by bradykinin alters responses of rat nociceptor and human itch sensation.
    Neuroscience letters, 1993, Apr-02, Volume: 152, Issue:1-2

    Topics: Adult; Animals; Bradykinin; Female; Histamine; Humans; Iontophoresis; Male; Middle Aged; Models, Bio

1993
Effect of topically applied menthol on thermal, pain and itch sensations and biophysical properties of the skin.
    Archives of dermatological research, 1996, Volume: 288, Issue:5-6

    Topics: Administration, Topical; Adult; Biophysical Phenomena; Biophysics; Female; Histamine; Hot Temperatur

1996
Investigation into the role of histamine receptors in rodent antinociception.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 53, Issue:3

    Topics: Animals; Burimamide; Dose-Response Relationship, Drug; Histamine; Impromidine; Male; Mice; Mice, Inb

1996
Asymmetry and time-course of cutaneous sympathetic reflex responses following sustained excitation of chemosensitive nociceptors in humans.
    Journal of the autonomic nervous system, 1996, Feb-05, Volume: 57, Issue:1-2

    Topics: Adult; Afferent Pathways; Female; Histamine; Humans; Male; Middle Aged; Mustard Plant; Pain; Pain Me

1996
Central serotonergic and histaminergic modulation of peripheral inflammation and nociception in rats.
    Indian journal of physiology and pharmacology, 1996, Volume: 40, Issue:2

    Topics: Animals; Foot; Formaldehyde; Histamine; Histamine Agonists; Histamine Antagonists; Inflammation; Inj

1996
Plasma extravasation and neuropeptide release in human skin as measured by intradermal microdialysis.
    Neuroscience letters, 1997, Jul-18, Volume: 230, Issue:2

    Topics: Adult; Axons; Calcitonin Gene-Related Peptide; Capsaicin; Forearm; Histamine; Humans; Inflammation;

1997
Effects of cutaneous histamine application in patients with sympathetic reflex dystrophy.
    Muscle & nerve, 1997, Volume: 20, Issue:11

    Topics: Adult; Axons; Female; Histamine; Humans; Iontophoresis; Male; Middle Aged; Pain; Reference Values; R

1997
Antinociceptive activity of impentamine, a histamine congener, after CNS administration.
    Life sciences, 1999, Volume: 64, Issue:5

    Topics: Analgesics; Animals; Cerebral Ventricles; Dose-Response Relationship, Drug; Guinea Pigs; Histamine;

1999
Capsaicin sensitivity and voltage-gated sodium currents in colon sensory neurons from rat dorsal root ganglia.
    The American journal of physiology, 1999, Volume: 277, Issue:6

    Topics: Action Potentials; Adenosine; Analgesics; Animals; Bradykinin; Capsaicin; Carbocyanines; Colon; Dino

1999
Activation of spinal wide dynamic range neurons by intracutaneous microinjection of nicotine.
    Journal of neurophysiology, 1999, Volume: 82, Issue:6

    Topics: Action Potentials; Animals; Azetidines; Histamine; Histamine H1 Antagonists; Hot Temperature; Male;

1999
In vivo signal transduction of nociceptive response by kyotorphin (tyrosine-arginine) through Galpha(i)- and inositol trisphosphate-mediated Ca(2+) influx.
    Molecular pharmacology, 2000, Volume: 57, Issue:1

    Topics: Analgesics; Animals; Calcium; Calcium Channels; Endorphins; GTP-Binding Protein alpha Subunits, Gi-G

2000
Opposite modulation of histaminergic neurons by nociceptin and morphine.
    Neuropharmacology, 2000, Volume: 39, Issue:12

    Topics: Analgesics, Opioid; Animals; Histamine; Hypothalamus; Male; Mammillary Bodies; Membrane Potentials;

2000
Does the histaminergic system play a role in spinal nociception?
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 2000, Volume: 75, Issue:4

    Topics: Animals; Dose-Response Relationship, Drug; Histamine; Histamine Agonists; Histamine Antagonists; In

2000
Inhibitory effects of cimicifugae rhizoma extracts on histamine, bradykinin and COX-2 mediated inflammatory actions.
    Phytotherapy research : PTR, 2000, Volume: 14, Issue:8

    Topics: Animals; Bradykinin; Dinoprost; Enzyme-Linked Immunosorbent Assay; Guinea Pigs; Histamine; Ileum; In

2000
The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception.
    Neuroscience, 2001, Volume: 102, Issue:4

    Topics: Animals; Anti-Asthmatic Agents; Cimetidine; Cromolyn Sodium; Histamine; Histamine H1 Antagonists; Hi

2001
Chronic low-level administration of diquat increases the nociceptive response to gastric distension in rats: role of mast cells and tachykinin receptor activation.
    Pain, 2001, Volume: 92, Issue:1-2

    Topics: Animals; Blood Pressure; Bronchodilator Agents; Diquat; Food Contamination; Gastric Dilatation; Herb

2001
Central activation by histamine-induced itch: analogies to pain processing: a correlational analysis of O-15 H2O positron emission tomography studies.
    Pain, 2001, Volume: 92, Issue:1-2

    Topics: Adult; Cerebral Cortex; Cerebrovascular Circulation; Histamine; Humans; Male; Oxygen Radioisotopes;

2001
Histamine H1 receptor mRNA is expressed in capsaicin-insensitive sensory neurons with neuropeptide Y-immunoreactivity in guinea pigs.
    Brain research, 2001, May-18, Volume: 901, Issue:1-2

    Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Ganglia, Spinal; Guinea Pigs; Histamine; Immuno

2001
Histamine-induced itch converts into pain in neuropathic hyperalgesia.
    Neuroreport, 2001, Nov-16, Volume: 12, Issue:16

    Topics: Histamine; Hot Temperature; Humans; Hyperalgesia; Nociceptors; Pain; Pruritus

2001
ReN 1869, a novel tricyclic antihistamine, is active against neurogenic pain and inflammation.
    European journal of pharmacology, 2002, Jan-18, Volume: 435, Issue:1

    Topics: Animals; Benzoquinones; Binding Sites; Calcitonin Gene-Related Peptide; Calcium; Calcium Channels; C

2002
Responses of superficial dorsal horn neurons to intradermal serotonin and other irritants: comparison with scratching behavior.
    Journal of neurophysiology, 2002, Volume: 87, Issue:3

    Topics: Animals; Behavior, Animal; Capsaicin; Disinfectants; Electrophysiology; Formaldehyde; Histamine; Inj

2002
ATP responses in human C nociceptors.
    Pain, 2002, Volume: 98, Issue:1-2

    Topics: Adenosine Triphosphate; Adult; Dose-Response Relationship, Drug; Female; Histamine; Hot Temperature;

2002
Biochemical basis of analgesia: metabolism, storage, regulation, and action.
    Dental clinics of North America, 1978, Volume: 22, Issue:1

    Topics: Analgesia; Bradykinin; Dopamine; Enkephalins; Glutamates; Histamine; Neurotransmitter Agents; Norepi

1978
Management of benign disease of the breast.
    The American surgeon, 1978, Volume: 44, Issue:10

    Topics: Breast; Breast Diseases; Breast Neoplasms; Cysts; Female; Histamine; Histamine H1 Antagonists; Hormo

1978
Nervous outflow from skeletal muscle following chemical noxious stimulation.
    The Journal of physiology, 1977, Volume: 267, Issue:1

    Topics: Animals; Bradykinin; Cats; Histamine; Muscle Spindles; Muscles; Nerve Fibers, Myelinated; Neurons, A

1977
Inflammation and the role of endogenous pain-producing substances.
    Dental clinics of North America, 1978, Volume: 22, Issue:1

    Topics: Acetaminophen; Anti-Inflammatory Agents; Bradykinin; Histamine; Humans; Inflammation; Kallikreins; K

1978
Activation of afferent cardiac sympathetic nerve fibers of the cat by pain producing substances and by noxious heat.
    Pflugers Archiv : European journal of physiology, 1977, Nov-25, Volume: 372, Issue:1

    Topics: Acetylcholine; Action Potentials; Animals; Bradykinin; Cats; Chemoreceptor Cells; Female; Heart; His

1977
Comparative analgetic testing of various compounds in mice using writhing techniques.
    Arzneimittel-Forschung, 1978, Volume: 28, Issue:9

    Topics: Acetylcholine; Analgesics; Animals; Bradykinin; Histamine; Lethal Dose 50; Male; Mice; Pain; Quinone

1978
Action of U.V. rays on the the experimental cutaneous inflammation induced by cantharidin.
    Advances in experimental medicine and biology, 1976, Volume: 70, Issue:00

    Topics: Cantharidin; Dermatitis, Contact; Histamine; Humans; Inflammation; Pain; Radiation Effects; Time Fac

1976
Evidence for the existence of different receptor sites for algesic agents at the endings of muscular group IV afferent units.
    Pflugers Archiv : European journal of physiology, 1976, Mar-30, Volume: 362, Issue:2

    Topics: Animals; Bradykinin; Cats; Electrophysiology; Histamine; Injections, Intra-Arterial; Injections, Int

1976
The effect of thiazol-4-yimethoxyamine, a histidine decarboxylase inhibitor, on the development of morphine tolerance and physical dependance in mice.
    Experientia, 1976, Oct-15, Volume: 32, Issue:10

    Topics: Animals; Behavior, Animal; Brain; Carboxy-Lyases; Drug Tolerance; Female; Histamine; Histidine Decar

1976
Chemosensitive spinal afferents: thresholds of specific and nociceptive reflexes as compared with thresholds of excitation for receptors and axons.
    Progress in brain research, 1976, Volume: 43

    Topics: Acetylcholine; Animals; Blood Pressure; Bradykinin; Carbachol; Cats; Chemoreceptor Cells; Histamine;

1976
Electrophysiological correlates for antinociceptive effects of histamine after intracerebral administration to the rat.
    Neuropharmacology, 1992, Volume: 31, Issue:9

    Topics: Analgesics; Animals; Arthritis, Experimental; Brain; Electrophysiology; Evoked Potentials; Histamine

1992
Vasodilator flare due to activation of superficial cutaneous afferents in humans: heat-sensitive versus histamine-sensitive fibers.
    Neuroscience letters, 1992, Jul-20, Volume: 141, Issue:2

    Topics: Histamine; Hot Temperature; Humans; Microcirculation; Nerve Fibers; Neurons, Afferent; Pain; Pruritu

1992
Neuropathic pain behavior in rats depends on the afferent input from nerve-end neuroma including histamine-sensitive C-fibers.
    Neuroscience letters, 1991, Jul-22, Volume: 128, Issue:2

    Topics: Animals; Astemizole; Behavior, Animal; Histamine; Histamine H1 Antagonists; Male; Nerve Endings; Ner

1991
[Role of pain component in the organization of chemosensory taste reaction].
    Biulleten' eksperimental'noi biologii i meditsiny, 1991, Volume: 112, Issue:8

    Topics: Animals; Capsicum; Chemoreceptor Cells; Fluorescence; Histamine; Histamine Release; Histocytochemist

1991
Discharge patterns of human C-fibers induced by itching and burning stimuli.
    Journal of neurophysiology, 1991, Volume: 66, Issue:1

    Topics: Adult; Electric Stimulation; Female; Histamine; Humans; Male; Middle Aged; Mustard Plant; Nerve Fibe

1991
Involvement of histamine in naloxone-resistant and naloxone-sensitive models of swim stress-induced antinociception in the mouse.
    Neuropharmacology, 1991, Volume: 30, Issue:9

    Topics: Animals; Drug Tolerance; Histamine; Histamine Antagonists; Hot Temperature; Male; Mice; Mice, Inbred

1991
[The role of humoral factors in the mechanism of the analgesic effect of electroacupuncture].
    Anaesthesiologie und Reanimation, 1990, Volume: 15, Issue:3

    Topics: Animals; Dinoprost; Dogs; Electroacupuncture; Enkephalin, Leucine; Enkephalin, Methionine; Histamine

1990
[Use of cimetidine with histamine in 4 patients with inoperable neoplasms of the upper part of the digestive tract].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1985, Oct-15, Volume: 38, Issue:20

    Topics: Adenocarcinoma; Aged; Carcinoma; Cimetidine; Drug Therapy, Combination; Esophageal Neoplasms; Histam

1985
On the nature of the afferent fibers of oculomotor nerve.
    Archives italiennes de biologie, 1989, Volume: 127, Issue:2

    Topics: Animals; Bradykinin; Capsaicin; Histamine; Hot Temperature; Nociceptors; Oculomotor Nerve; Pain; She

1989
A role for histamine and histamine H2-receptors in non-opiate footshock-induced analgesia.
    Life sciences, 1985, Mar-04, Volume: 36, Issue:9

    Topics: Animals; Cimetidine; Electroshock; Haloperidol; Histamine; Histamine H2 Antagonists; Male; Naloxone;

1985
Reflex excitation of masticatory muscles induced by algesic chemicals applied to the temporomandibular joint of the cat.
    Archives of oral biology, 1988, Volume: 33, Issue:10

    Topics: Animals; Cats; Histamine; Masticatory Muscles; Pain; Potassium Chloride; Reflex; Sodium Chloride; Te

1988
Effects of temporomandibular joint stimulation on nociceptive and nonnociceptive neurons of the cat's trigeminal subnucleus caudalis (medullary dorsal horn).
    Journal of neurophysiology, 1988, Volume: 59, Issue:5

    Topics: Animals; Bradykinin; Cats; Electric Stimulation; Histamine; Neurons, Afferent; Nociceptors; Pain; Ph

1988
Congenital familial sensory neuropathy with anhidrosis.
    The Journal of pediatrics, 1966, Volume: 68, Issue:1

    Topics: Child; Child, Preschool; Dysautonomia, Familial; Female; Histamine; Humans; Intellectual Disability;

1966
A case of congenital indifference to pain (neurologic and psychiatric findings).
    Diseases of the nervous system, 1968, Volume: 29, Issue:6

    Topics: Adult; Electric Stimulation; Female; Galvanic Skin Response; Histamine; Humans; Pain; Pain Insensiti

1968
Multiple (subcutaneous) angiolipomas. Clinical, pathologic, and pharmacologic studies.
    Archives of dermatology, 1974, Volume: 110, Issue:4

    Topics: Adenosine Triphosphatases; Adult; Alkaline Phosphatase; Blood Vessels; Cold Temperature; Hemangioma;

1974
Action of peptides and other algesic agents on paravascular pain receptors of the isolated perfused rabbit ear.
    Naunyn-Schmiedeberg's archives of pharmacology, 1974, Volume: 283, Issue:2

    Topics: Acetylcholine; Action Potentials; Adenosine; Adenosine Triphosphate; Angiotensin II; Animals; Blood

1974
Antagonism by aspirin and fenamates of bronchoconstriction and nociception induced by adenosine-5'-triphosphate.
    Nature, 1966, Oct-22, Volume: 212, Issue:5060

    Topics: Acetylcholine; Adenine Nucleotides; Adenosine Triphosphate; Anaphylaxis; Animals; Anti-Inflammatory

1966
Cortical potentials evoked by nociceptive stimuli: their depression by a factor released during saphenous nerve stimulation in the rat.
    British journal of pharmacology, 1974, Volume: 51, Issue:4

    Topics: Adenosine Triphosphate; Animals; Aspirin; Bradykinin; Cerebral Cortex; Dental Pulp; Dose-Response Re

1974
In vivo and in vitro evaluation of liquid antacids.
    The New England journal of medicine, 1973, May-03, Volume: 288, Issue:18

    Topics: Aluminum Hydroxide; Antacids; Dose-Response Relationship, Drug; Duodenal Ulcer; Esophagitis, Peptic;

1973
Pain problems of significance in the head and face, some of which often are misdiagnosed.
    Current problems in surgery, 1973

    Topics: Adult; Brain Neoplasms; Cerebral Arteries; Diagnosis, Differential; Face; Facial Neuralgia; Female;

1973
Influence of body posture on leg blood flow.
    Angiologica, 1973, Volume: 10, Issue:3

    Topics: Arteries; Female; Histamine; Humans; Hypertension; Intermittent Claudication; Ischemia; Leg; Male; M

1973
Activation of group IV afferent units from muscle by algesic agents.
    Brain research, 1974, Jun-07, Volume: 72, Issue:2

    Topics: Animals; Bradykinin; Cats; Histamine; Muscles; Neural Conduction; Neurons; Neurons, Afferent; Pain;

1974
Histamine explanation of acupuncture.
    JAMA, 1972, Jun-05, Volume: 220, Issue:10

    Topics: Acupuncture Therapy; Capillaries; Epinephrine; Histamine; Humans; Pain

1972
[Effect of adrenaline, acetylcholine and histamine on human sensations of pain].
    Nervnaia sistema, 1971, Volume: 12

    Topics: Acetylcholine; Epinephrine; Histamine; Humans; Pain; Peripheral Nerves; Skin

1971
[Pain producing substances].
    Hippokrates, 1969, Oct-31, Volume: 40, Issue:20

    Topics: Chemoreceptor Cells; Extracellular Space; Histamine; Humans; Kinins; Pain; Potassium; Serotonin

1969
[Chemical mediators of pain].
    Minerva anestesiologica, 1969, Volume: 35, Issue:11

    Topics: Acetylcholine; Amides; Catecholamines; Histamine; Humans; Kinins; Pain; Potassium; Serotonin

1969
[Clinical trials in the therapy of peptic ulcer. 3. Ambulatary therapy of uncomplicated duodenal ulcer with diverse anticholinergic agents].
    Das Deutsche Gesundheitswesen, 1970, Mar-25, Volume: 25, Issue:12

    Topics: Antacids; Benzilates; Choline; Delayed-Action Preparations; Duodenal Ulcer; Gastric Juice; Heartburn

1970
Headache and eye pain.
    International ophthalmology clinics, 1967,Winter, Volume: 7, Issue:4

    Topics: Brain Neoplasms; Cerebrovascular Disorders; Eye Diseases; Facial Neuralgia; Giant Cell Arteritis; He

1967
[Anatomo-physiopathology of pain].
    Minerva anestesiologica, 1967, Volume: 33, Issue:11

    Topics: Histamine; Humans; Kinins; Pain; Perception; Sensory Receptor Cells; Serotonin; Thalamus

1967
Vocalization response of puppies to intra-arterial administration of bradykinin and other algesic agents, and mode of actions of blocking agents.
    The Tohoku journal of experimental medicine, 1968, Volume: 96, Issue:4

    Topics: Acetylcholine; Age Factors; Analgesics; Animals; Atropine; Barium; Bradykinin; Catheterization; Chlo

1968