ulixacaltamide has been researched along with Pain* in 2 studies
2 other study(ies) available for ulixacaltamide and Pain
Article | Year |
---|---|
The T-type calcium channel antagonist, Z944, reduces spinal excitability and pain hypersensitivity.
T-type voltage-gated calcium channels are an emerging therapeutic target for neurological disorders including epilepsy and pain. Inhibition of T-type channels reduces the excitability of peripheral nociceptive sensory neurons and reverses pain hypersensitivity in male rodent pain models. However, administration of peripherally restricted T-type antagonists failed to show efficacy in multiple clinical and preclinical pain trials, suggesting that inhibition of peripheral T-type channels alone may be insufficient for pain relief.. We utilized the selective and CNS-penetrant T-type channel antagonist, Z944, in electrophysiological, calcium imaging and behavioural paradigms to determine its effect on lamina I neuron excitability and inflammatory pain behaviours.. Voltage-clamp recordings from lamina I spinal neurons of adult rats revealed that approximately 80% of neurons possess a low threshold T-type current, which was blocked by Z944. Due to this highly prevalent T-type current, Z944 potently blocked action-potential evoked somatic and dendritic calcium transients in lamina I neurons. Moreover, application of Z944 to spinal cord slices attenuated action potential firing rates in over half of laminae I/II neurons. Finally, we found that intraperitoneal injection of Z944 (1-10 mg·kg. T-type calcium channels critically shape the excitability of lamina I pain processing neurons and inhibition of these channels by the clinical stage antagonist Z944 potently reverses pain hypersensitivity across sexes. Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Female; Male; Pain; Piperidines; Rats; Spinal Cord Dorsal Horn | 2021 |
Z944: a first in class T-type calcium channel modulator for the treatment of pain.
Topics: Acetamides; Administration, Oral; Benzamides; Calcium Channel Blockers; Capsaicin; Clinical Trials, Phase I as Topic; Dose-Response Relationship, Drug; Evoked Potentials, Somatosensory; Humans; Lasers; Male; Pain; Piperidines; Time Factors | 2014 |