Page last updated: 2024-11-12
rosmanol
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
rosmanol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 13966122 |
CHEMBL ID | 507166 |
SCHEMBL ID | 459610 |
MeSH ID | M0438979 |
Synonyms (21)
Synonym |
---|
rosmanol |
CHEMBL507166 |
AKOS016004074 |
2h-10,4a-(epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6,9-trihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4ar-(4a.alpha.,9.beta.,10.alpha.,10a.beta.))- |
2h-10,4a-(epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6,9-trihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4ar,9s,10s,10as)- |
F25TV383OC , |
33985-86-3 |
(6beta,7alpha)-7,11,12-trihydroxy-6,20-epoxyabieta-8(14),9(11),12-trien-20-one |
unii-f25tv383oc |
2h-10,4a-(epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6,9-trihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4ar-(4aalpha,9beta,10alpha,10abeta))- |
80225-53-2 |
SCHEMBL459610 |
(4br,8as,9s,10s)-3,4,10-trihydroxy-2-isopropyl-8,8-dimethyl-6,7,8,8a,9,10-hexahydro-5h-9,4b-(epoxymethano)phenanthren-12-one |
AC-34511 |
DTXSID80553423 |
CS-0032078 |
HY-N5015 |
Q27277536 |
(1r,8s,9s,10s)-3,4,8-trihydroxy-11,11-dimethyl-5-propan-2-yl-16-oxatetracyclo[7.5.2.01,10.02,7]hexadeca-2,4,6-trien-15-one |
D85077 |
MS-25326 |
Research Excerpts
Overview
Rosmanol is a natural polyphenol from the herb rosemary (Rosmarinus officinalis L.) with high antioxidant activity.
Excerpt | Reference | Relevance |
---|---|---|
"Rosmanol is a natural polyphenol from the herb rosemary (Rosmarinus officinalis L.) with high antioxidant activity. " | ( Rosmanol potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-kappaB, STAT3 and C/EBP signaling pathways. Ho, CT; Lai, CS; Lee, JH; Liu, CB; Pan, MH; Wang, JM; Wang, YJ, 2009) | 3.24 |
Treatment
Excerpt | Reference | Relevance |
---|---|---|
"Treatment with rosmanol also reduced translocation of the nuclear factor-kappaB (NF-kappaB) subunits by prevention of the degradation and phosphorylation of inhibitor kappaB (IkappaB)." | ( Rosmanol potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-kappaB, STAT3 and C/EBP signaling pathways. Ho, CT; Lai, CS; Lee, JH; Liu, CB; Pan, MH; Wang, JM; Wang, YJ, 2009) | 2.14 |
Bioavailability
Excerpt | Reference | Relevance |
---|---|---|
" The aim of this study was to investigate the bioavailability of these compounds in a rat model of obesity." | ( Bioavailability of the major bioactive diterpenoids in a rosemary extract: metabolic profile in the intestine, liver, plasma, and brain of Zucker rats. Espín, JC; Flanagan, J; Fromentin, E; García Villalba, R; García-Conesa, MT; Larrosa, M; Roller, M; Romo Vaquero, M; Tomás-Barberán, FA; Yáñez-Gascón, MJ, 2013) | 0.39 |
Dosage Studied
Excerpt | Relevance | Reference |
---|---|---|
" In addition, the polyphenols dose-response correlations with cellular antioxidant activity were also determined." | ( Antioxidant activity evaluation of rosemary ethanol extract and their cellular antioxidant activity toward HeLa cells. Jiang, ZT; Li, R; Nie, JY; Tan, J; Tang, SH; Wang, Y, 2019) | 0.51 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (51)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID471604 | Cytotoxicity against human A549 cells at lag phase of growth after 48 hrs by MTT assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
AID1756071 | Antibiofilm activity against Escherichia coli DSM 8579 assessed as inhibition of biofilm formation at 40 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control | |||
AID335102 | Inhibition of bovine spleen cathepsin D up to 10 ug/ml | 1993 | Journal of natural products, Aug, Volume: 56, Issue:8 | Inhibitory effect of carnosic acid on HIV-1 protease in cell-free assays [corrected]. |
AID471598 | Antibacterial activity against Pseudomonas aeruginosa AK958 after 24 hrs by broth dilution assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
AID1756084 | Antibiofilm activity against Escherichia coli DSM 8579 assessed as inhibition of bacterial metabolism within the biofilm at 80 ug/ml measured after 48 hrs by MTT assay relative to control | |||
AID1756077 | Antibiofilm activity against Pectobacterium carotovorum ATCC 15713 assessed as inhibition of bacterial metabolism within the biofilm at 4 ug/ml measured after 48 hrs by MTT assay relative to control | |||
AID471602 | Cytotoxicity against human Hep2 cells at lag phase of growth after 48 hrs by MTT assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
AID744357 | Activation of Nrf2/ARE in E15 stage mouse primary cortical neurons after 48 hrs by human placental alkaline phosphatase reporter gene assay | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9 | Structure activity relationship of phenolic diterpenes from Salvia officinalis as activators of the nuclear factor E2-related factor 2 pathway. |
AID471356 | Antibacterial activity against Bacillus cereus ATCC 21772 after 24 hrs by broth dilution assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
AID471605 | Cytotoxicity against human A549 cells at exponential phase of growth after 48 hrs by MTT assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
AID1756076 | Antibiofilm activity against Acinetobacter baumannii ATCC 19606 assessed as inhibition of bacterial metabolism within the biofilm at 4 ug/ml measured after 48 hrs by MTT assay relative to control | |||
AID1756070 | Antibiofilm activity against Pectobacterium carotovorum ATCC 15713 assessed as inhibition of biofilm formation at 8 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control | |||
AID1756079 | Antibiofilm activity against Pseudomonas aeruginosa ATCC 50071 assessed as inhibition of bacterial metabolism within the biofilm at 8 ug/ml measured after 48 hrs by MTT assay relative to control | |||
AID471601 | Cytotoxicity against human HeLa cells at exponential phase of growth after 48 hrs by MTT assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
AID471357 | Antibacterial activity against Candida albicans CECT 170 after 24 hrs by broth dilution assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
AID471358 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 24 hrs by broth dilution assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
AID471608 | Cytotoxicity against african green monkey Vero cells at lag phase of growth after 48 hrs by MTT assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
AID1756072 | Antibiofilm activity against Escherichia coli DSM 8579 assessed as inhibition of biofilm formation at 80 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control | |||
AID1603993 | Induction of apoptosis in human COLO205 cells after 24 hrs | 2019 | European journal of medicinal chemistry, Nov-01, Volume: 181 | The Mediterranean Diet as source of bioactive compounds with multi-targeting anti-cancer profile. |
AID471603 | Cytotoxicity against human Hep2 cells at exponential phase of growth after 48 hrs by MTT assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
AID471354 | Antibacterial activity against Staphylococcus epidermidis ATCC 14990 after 24 hrs by broth dilution assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
AID471355 | Antibacterial activity against Bacillus subtilis ATCC 6051 after 24 hrs by broth dilution assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
AID1756063 | Antibiofilm activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of biofilm formation at 4 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control | |||
AID1756075 | Antibiofilm activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial metabolism within the biofilm at 4 ug/ml measured after 48 hrs by MTT assay relative to control | |||
AID1756069 | Antibiofilm activity against Acinetobacter baumannii ATCC 19606 assessed as inhibition of biofilm formation at 8 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control | |||
AID471609 | Cytotoxicity against african green monkey Vero cells at exponential phase of growth after 48 hrs by MTT assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
AID1756066 | Antibiofilm activity against Listeria monocytogenes ATCC 7644 assessed as inhibition of biofilm formation at 8 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control | |||
AID471599 | Antibacterial activity against Salmonella CECT 4569 after 24 hrs by broth dilution assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
AID1756062 | Antibiofilm activity against Pseudomonas aeruginosa ATCC 50071 assessed as inhibition of biofilm formation at 4 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control | |||
AID335101 | Inhibition of HIV1 recombinant protease expressed in Escherichia coli BL21 (DE3) cells by SDS-PAGE | 1993 | Journal of natural products, Aug, Volume: 56, Issue:8 | Inhibitory effect of carnosic acid on HIV-1 protease in cell-free assays [corrected]. |
AID1756065 | Antibiofilm activity against Pectobacterium carotovorum ATCC 15713 assessed as inhibition of biofilm formation at 4 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control | |||
AID335105 | Inhibition of pig pepsin up to 10 ug/ml | 1993 | Journal of natural products, Aug, Volume: 56, Issue:8 | Inhibitory effect of carnosic acid on HIV-1 protease in cell-free assays [corrected]. |
AID1756061 | Antibiofilm activity against Listeria monocytogenes ATCC 7644 assessed as inhibition of biofilm formation at 4 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control | |||
AID471597 | Antibacterial activity against Proteus mirabilis CECT 170 after 24 hrs by broth dilution assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
AID1756078 | Antibiofilm activity against Listeria monocytogenes ATCC 7644 assessed as inhibition of bacterial metabolism within the biofilm at 8 ug/ml measured after 48 hrs by MTT assay relative to control | |||
AID1756067 | Antibiofilm activity against Pseudomonas aeruginosa ATCC 50071 assessed as inhibition of biofilm formation at 8 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control | |||
AID1756083 | Antibiofilm activity against Escherichia coli DSM 8579 assessed as inhibition of bacterial metabolism within the biofilm at 40 ug/ml measured after 48 hrs by MTT assay relative to control | |||
AID471607 | Cytotoxicity against human sMCF7 cells at exponential phase of growth after 48 hrs by MTT assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
AID1756073 | Antibiofilm activity against Listeria monocytogenes ATCC 7644 assessed as inhibition of bacterial metabolism within the biofilm at 4 ug/ml measured after 48 hrs by MTT assay relative to control | |||
AID1756068 | Antibiofilm activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of biofilm formation at 8 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control | |||
AID471606 | Cytotoxicity against human MCF7 cells at lag phase of growth after 48 hrs by MTT assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
AID1756074 | Antibiofilm activity against Pseudomonas aeruginosa ATCC 50071 assessed as inhibition of bacterial metabolism within the biofilm at 4 ug/ml measured after 48 hrs by MTT assay relative to control | |||
AID1756080 | Antibiofilm activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial metabolism within the biofilm at 8 ug/ml measured after 48 hrs by MTT assay relative to control | |||
AID1603994 | Induction of apoptosis in human COLO205 cells after 24 hrs relative to control | 2019 | European journal of medicinal chemistry, Nov-01, Volume: 181 | The Mediterranean Diet as source of bioactive compounds with multi-targeting anti-cancer profile. |
AID744356 | Activation of Nrf2/ARE in E15 stage mouse primary cortical neurons at 6.25 to 50 uM after 48 hrs by human placental alkaline phosphatase reporter gene assay | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9 | Structure activity relationship of phenolic diterpenes from Salvia officinalis as activators of the nuclear factor E2-related factor 2 pathway. |
AID1756082 | Antibiofilm activity against Pectobacterium carotovorum ATCC 15713 assessed as inhibition of bacterial metabolism within the biofilm at 8 ug/ml measured after 48 hrs by MTT assay relative to control | |||
AID471600 | Cytotoxicity against human HeLa cells at lag phase of growth after 48 hrs by MTT assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
AID1756064 | Antibiofilm activity against Acinetobacter baumannii ATCC 19606 assessed as inhibition of biofilm formation at 4 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control | |||
AID471353 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by broth dilution assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
AID471596 | Antibacterial activity against Escherichia coli ATCC 9637 after 24 hrs by broth dilution assay | 2009 | Journal of natural products, Aug, Volume: 72, Issue:8 | Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. |
AID1756081 | Antibiofilm activity against Acinetobacter baumannii ATCC 19606 assessed as inhibition of bacterial metabolism within the biofilm at 8 ug/ml measured after 48 hrs by MTT assay relative to control | |||
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (21)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (4.76) | 18.2507 |
2000's | 9 (42.86) | 29.6817 |
2010's | 8 (38.10) | 24.3611 |
2020's | 3 (14.29) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 31.88
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (31.88) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 3 (13.04%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 20 (86.96%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |