Compounds > rosmanol
Page last updated: 2024-11-12

rosmanol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

rosmanol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID13966122
CHEMBL ID507166
SCHEMBL ID459610
MeSH IDM0438979

Synonyms (21)

Synonym
rosmanol
CHEMBL507166
AKOS016004074
2h-10,4a-(epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6,9-trihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4ar-(4a.alpha.,9.beta.,10.alpha.,10a.beta.))-
2h-10,4a-(epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6,9-trihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4ar,9s,10s,10as)-
F25TV383OC ,
33985-86-3
(6beta,7alpha)-7,11,12-trihydroxy-6,20-epoxyabieta-8(14),9(11),12-trien-20-one
unii-f25tv383oc
2h-10,4a-(epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6,9-trihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4ar-(4aalpha,9beta,10alpha,10abeta))-
80225-53-2
SCHEMBL459610
(4br,8as,9s,10s)-3,4,10-trihydroxy-2-isopropyl-8,8-dimethyl-6,7,8,8a,9,10-hexahydro-5h-9,4b-(epoxymethano)phenanthren-12-one
AC-34511
DTXSID80553423
CS-0032078
HY-N5015
Q27277536
(1r,8s,9s,10s)-3,4,8-trihydroxy-11,11-dimethyl-5-propan-2-yl-16-oxatetracyclo[7.5.2.01,10.02,7]hexadeca-2,4,6-trien-15-one
D85077
MS-25326

Research Excerpts

Overview

Rosmanol is a natural polyphenol from the herb rosemary (Rosmarinus officinalis L.) with high antioxidant activity.

ExcerptReferenceRelevance
"Rosmanol is a natural polyphenol from the herb rosemary (Rosmarinus officinalis L.) with high antioxidant activity. "( Rosmanol potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-kappaB, STAT3 and C/EBP signaling pathways.
Ho, CT; Lai, CS; Lee, JH; Liu, CB; Pan, MH; Wang, JM; Wang, YJ, 2009)		3.24

Treatment

ExcerptReferenceRelevance
"Treatment with rosmanol also reduced translocation of the nuclear factor-kappaB (NF-kappaB) subunits by prevention of the degradation and phosphorylation of inhibitor kappaB (IkappaB)."( Rosmanol potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-kappaB, STAT3 and C/EBP signaling pathways.
Ho, CT; Lai, CS; Lee, JH; Liu, CB; Pan, MH; Wang, JM; Wang, YJ, 2009)		2.14

Bioavailability

ExcerptReferenceRelevance
" The aim of this study was to investigate the bioavailability of these compounds in a rat model of obesity."( Bioavailability of the major bioactive diterpenoids in a rosemary extract: metabolic profile in the intestine, liver, plasma, and brain of Zucker rats.
Espín, JC; Flanagan, J; Fromentin, E; García Villalba, R; García-Conesa, MT; Larrosa, M; Roller, M; Romo Vaquero, M; Tomás-Barberán, FA; Yáñez-Gascón, MJ, 2013)		0.39

Dosage Studied

ExcerptRelevanceReference
" In addition, the polyphenols dose-response correlations with cellular antioxidant activity were also determined."( Antioxidant activity evaluation of rosemary ethanol extract and their cellular antioxidant activity toward HeLa cells.
Jiang, ZT; Li, R; Nie, JY; Tan, J; Tang, SH; Wang, Y, 2019)		0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (51)

Assay IDTitleYearJournalArticle
AID471604Cytotoxicity against human A549 cells at lag phase of growth after 48 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID1756071Antibiofilm activity against Escherichia coli DSM 8579 assessed as inhibition of biofilm formation at 40 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control
AID335102Inhibition of bovine spleen cathepsin D up to 10 ug/ml1993Journal of natural products, Aug, Volume: 56, Issue:8
Inhibitory effect of carnosic acid on HIV-1 protease in cell-free assays [corrected].
AID471598Antibacterial activity against Pseudomonas aeruginosa AK958 after 24 hrs by broth dilution assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID1756084Antibiofilm activity against Escherichia coli DSM 8579 assessed as inhibition of bacterial metabolism within the biofilm at 80 ug/ml measured after 48 hrs by MTT assay relative to control
AID1756077Antibiofilm activity against Pectobacterium carotovorum ATCC 15713 assessed as inhibition of bacterial metabolism within the biofilm at 4 ug/ml measured after 48 hrs by MTT assay relative to control
AID471602Cytotoxicity against human Hep2 cells at lag phase of growth after 48 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID744357Activation of Nrf2/ARE in E15 stage mouse primary cortical neurons after 48 hrs by human placental alkaline phosphatase reporter gene assay2013Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
Structure activity relationship of phenolic diterpenes from Salvia officinalis as activators of the nuclear factor E2-related factor 2 pathway.
AID471356Antibacterial activity against Bacillus cereus ATCC 21772 after 24 hrs by broth dilution assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID471605Cytotoxicity against human A549 cells at exponential phase of growth after 48 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID1756076Antibiofilm activity against Acinetobacter baumannii ATCC 19606 assessed as inhibition of bacterial metabolism within the biofilm at 4 ug/ml measured after 48 hrs by MTT assay relative to control
AID1756070Antibiofilm activity against Pectobacterium carotovorum ATCC 15713 assessed as inhibition of biofilm formation at 8 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control
AID1756079Antibiofilm activity against Pseudomonas aeruginosa ATCC 50071 assessed as inhibition of bacterial metabolism within the biofilm at 8 ug/ml measured after 48 hrs by MTT assay relative to control
AID471601Cytotoxicity against human HeLa cells at exponential phase of growth after 48 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID471357Antibacterial activity against Candida albicans CECT 170 after 24 hrs by broth dilution assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID471358Antibacterial activity against Enterococcus faecalis ATCC 29212 after 24 hrs by broth dilution assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID471608Cytotoxicity against african green monkey Vero cells at lag phase of growth after 48 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID1756072Antibiofilm activity against Escherichia coli DSM 8579 assessed as inhibition of biofilm formation at 80 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control
AID1603993Induction of apoptosis in human COLO205 cells after 24 hrs2019European journal of medicinal chemistry, Nov-01, Volume: 181The Mediterranean Diet as source of bioactive compounds with multi-targeting anti-cancer profile.
AID471603Cytotoxicity against human Hep2 cells at exponential phase of growth after 48 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID471354Antibacterial activity against Staphylococcus epidermidis ATCC 14990 after 24 hrs by broth dilution assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID471355Antibacterial activity against Bacillus subtilis ATCC 6051 after 24 hrs by broth dilution assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID1756063Antibiofilm activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of biofilm formation at 4 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control
AID1756075Antibiofilm activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial metabolism within the biofilm at 4 ug/ml measured after 48 hrs by MTT assay relative to control
AID1756069Antibiofilm activity against Acinetobacter baumannii ATCC 19606 assessed as inhibition of biofilm formation at 8 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control
AID471609Cytotoxicity against african green monkey Vero cells at exponential phase of growth after 48 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID1756066Antibiofilm activity against Listeria monocytogenes ATCC 7644 assessed as inhibition of biofilm formation at 8 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control
AID471599Antibacterial activity against Salmonella CECT 4569 after 24 hrs by broth dilution assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID1756062Antibiofilm activity against Pseudomonas aeruginosa ATCC 50071 assessed as inhibition of biofilm formation at 4 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control
AID335101Inhibition of HIV1 recombinant protease expressed in Escherichia coli BL21 (DE3) cells by SDS-PAGE1993Journal of natural products, Aug, Volume: 56, Issue:8
Inhibitory effect of carnosic acid on HIV-1 protease in cell-free assays [corrected].
AID1756065Antibiofilm activity against Pectobacterium carotovorum ATCC 15713 assessed as inhibition of biofilm formation at 4 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control
AID335105Inhibition of pig pepsin up to 10 ug/ml1993Journal of natural products, Aug, Volume: 56, Issue:8
Inhibitory effect of carnosic acid on HIV-1 protease in cell-free assays [corrected].
AID1756061Antibiofilm activity against Listeria monocytogenes ATCC 7644 assessed as inhibition of biofilm formation at 4 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control
AID471597Antibacterial activity against Proteus mirabilis CECT 170 after 24 hrs by broth dilution assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID1756078Antibiofilm activity against Listeria monocytogenes ATCC 7644 assessed as inhibition of bacterial metabolism within the biofilm at 8 ug/ml measured after 48 hrs by MTT assay relative to control
AID1756067Antibiofilm activity against Pseudomonas aeruginosa ATCC 50071 assessed as inhibition of biofilm formation at 8 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control
AID1756083Antibiofilm activity against Escherichia coli DSM 8579 assessed as inhibition of bacterial metabolism within the biofilm at 40 ug/ml measured after 48 hrs by MTT assay relative to control
AID471607Cytotoxicity against human sMCF7 cells at exponential phase of growth after 48 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID1756073Antibiofilm activity against Listeria monocytogenes ATCC 7644 assessed as inhibition of bacterial metabolism within the biofilm at 4 ug/ml measured after 48 hrs by MTT assay relative to control
AID1756068Antibiofilm activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of biofilm formation at 8 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control
AID471606Cytotoxicity against human MCF7 cells at lag phase of growth after 48 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID1756074Antibiofilm activity against Pseudomonas aeruginosa ATCC 50071 assessed as inhibition of bacterial metabolism within the biofilm at 4 ug/ml measured after 48 hrs by MTT assay relative to control
AID1756080Antibiofilm activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial metabolism within the biofilm at 8 ug/ml measured after 48 hrs by MTT assay relative to control
AID1603994Induction of apoptosis in human COLO205 cells after 24 hrs relative to control2019European journal of medicinal chemistry, Nov-01, Volume: 181The Mediterranean Diet as source of bioactive compounds with multi-targeting anti-cancer profile.
AID744356Activation of Nrf2/ARE in E15 stage mouse primary cortical neurons at 6.25 to 50 uM after 48 hrs by human placental alkaline phosphatase reporter gene assay2013Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
Structure activity relationship of phenolic diterpenes from Salvia officinalis as activators of the nuclear factor E2-related factor 2 pathway.
AID1756082Antibiofilm activity against Pectobacterium carotovorum ATCC 15713 assessed as inhibition of bacterial metabolism within the biofilm at 8 ug/ml measured after 48 hrs by MTT assay relative to control
AID471600Cytotoxicity against human HeLa cells at lag phase of growth after 48 hrs by MTT assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID1756064Antibiofilm activity against Acinetobacter baumannii ATCC 19606 assessed as inhibition of biofilm formation at 4 ug/ml measured after 48 hrs by crystal violet staining based assay relative to control
AID471353Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by broth dilution assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID471596Antibacterial activity against Escherichia coli ATCC 9637 after 24 hrs by broth dilution assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
AID1756081Antibiofilm activity against Acinetobacter baumannii ATCC 19606 assessed as inhibition of bacterial metabolism within the biofilm at 8 ug/ml measured after 48 hrs by MTT assay relative to control
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (4.76)18.2507
2000's9 (42.86)29.6817
2010's8 (38.10)24.3611
2020's3 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 31.88

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index31.88 (24.57)
Research Supply Index3.18 (2.92)
Research Growth Index5.39 (4.65)
Search Engine Demand Index39.34 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (31.88)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (13.04%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other20 (86.96%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
methanol
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.		2.4220alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
quinone
benzoquinone : The simplest members of the class of benzoquinones, consisting of cyclohexadiene which is substituted by two oxo groups.. 1,4-benzoquinone : The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.. quinone : Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).		2.01101,4-benzoquinonescofactor;
human xenobiotic metabolite;
mouse metabolite
acetonitrile
acetonitrile: RN given refers to unlabeled cpd. acetonitrile : A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group.		2.0110aliphatic nitrile;
volatile organic compound		EC 3.5.1.4 (amidase) inhibitor;
NMR chemical shift reference compound;
polar aprotic solvent
ethyl acetate
ethyl acetate : The acetate ester formed between acetic acid and ethanol.		2.610acetate ester;
ethyl ester;
volatile organic compound		EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor;
metabolite;
polar aprotic solvent;
Saccharomyces cerevisiae metabolite
d-alpha tocopherol
Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.		2.0110alpha-tocopherolalgal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite
2-tert-butylhydroquinone
2-tert-butylhydroquinone: an anticarcinogenic and chemopreventive agent. 2-tert-butylhydroquinone : A member of the class of hydroquinones in which one of the ring hydrogens of hydroquinone is replaced by a tert-butyl group.		2.0810hydroquinonesfood antioxidant
salvin
salvin: a biocyclic diterpenoid; from sage and rosemary (Lamiaceae)		4.83100abietane diterpenoid;
carbotricyclic compound;
catechols;
monocarboxylic acid		angiogenesis modulating agent;
anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
food preservative;
HIV protease inhibitor;
plant metabolite
tangeretin
tangeretin: structure given in first source; from citrus plants; inhibits invasion of MO4 mouse cells into embryonic chick heart in vitro. tangeretin : A pentamethoxyflavone flavone with methoxy groups at positions 4', 5, 6 , 7 and 8.. pentamethoxyflavone : A methoxyflavone that is flavone substituted by a five methoxy groups.		3.3110pentamethoxyflavoneantineoplastic agent;
plant metabolite
hesperetin
[no description available]		3.31103'-hydroxyflavanones;
4'-methoxyflavanones;
monomethoxyflavanone;
trihydroxyflavanone		antineoplastic agent;
antioxidant;
plant metabolite
nobiletin
nobiletin : A methoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 8, 3' and 4' respectively.		3.3110methoxyflavoneantineoplastic agent;
plant metabolite
salvigenin
salvigenin: structure. salvigenin : A trimethoxyflavone that is scutellarein in which the hydroxy groups at positions 4', 6, and 7 are replaced by methoxy groups.		2.1110monohydroxyflavone;
trimethoxyflavone		antilipemic drug;
antineoplastic agent;
apoptosis inhibitor;
autophagy inducer;
hypoglycemic agent;
immunomodulator;
neuroprotective agent;
plant metabolite
cirsimaritin
cirsimaritin: has antagonist or partial agonist activity on benzodiazepine receptors. cirsimaritin : A dimethoxyflavone that is flavone substituted by methoxy groups at positions 6 and 7 and hydroxy groups at positions 5 and 4' respectively.		2.1110dihydroxyflavone;
dimethoxyflavone
taxifolin
(+)-taxifolin : A taxifolin that has (2R,3R)-configuration.		3.3110taxifolinmetabolite
carnosol
carnosol: isolated from Lepechinia hastata		9.92110diterpenoid
mercaptopurine
Mercaptopurine: An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.. purine-6-thiol : A thiol that is the tautomer of mercaptopurine.. mercaptopurine : A member of the class of purines that is 6,7-dihydro-1H-purine carrying a thione group at position 6. An adenine analogue, it is used in the treatment of acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn's disease, and ulcerative colitis.		2.0510aryl thiol;
purines;
thiocarbonyl compound		anticoronaviral agent;
antimetabolite;
antineoplastic agent
caffeic acid
trans-caffeic acid : The trans-isomer of caffeic acid.		2.0110caffeic acidgeroprotector;
mouse metabolite
1,1-diphenyl-2-picrylhydrazyl
1,1-diphenyl-2-picrylhydrazyl: A diphenyl picrate; the ability to decolorize this stable radical indicates reactivity of tested compounds (Banda, Anal Chem 46:1772-7 1974)		2.0110
quercetin
[no description available]		3.31107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		2.0510prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
cefotaxime
Cefotaxime: Semisynthetic broad-spectrum cephalosporin.. cefotaxime : A cephalosporin compound having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups.		2.05101,3-thiazoles;
cephalosporin;
oxime O-ether		antibacterial drug;
drug allergen
7-methoxyrosmanol
7-methoxyrosmanol: from Salvia dorrii; structure in first source		2.4120
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.		3.1150
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		03.9420
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.9420
Diathesis
[description not available]		02.3110
Rheumatoid Arthritis
[description not available]		07.3110
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.5820
Arthritis, Rheumatoid
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.		02.3110
Ache
[description not available]		02.1110
Anxiety
Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.		02.1110
Depression
Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.		02.1110
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.		02.1110
Adenocarcinoma, Basal Cell
[description not available]		02.0610
Cancer of Colon
[description not available]		02.0610
Adenocarcinoma
A malignant epithelial tumor with a glandular organization.		07.0610
Colonic Neoplasms
Tumors or cancer of the COLON.		02.0610
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)		02.0710