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m 8218

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

M 8218: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID137356
CHEMBL ID4594416
SCHEMBL ID6920037
MeSH IDM0155784

Synonyms (29)

Synonym
penehyclidine
benzenemethanol, alpha-((1-azabicyclo(2.2.2)oct-3-yloxy)methyl)-alpha-cyclopentyl-
87827-02-9
353cx8cshd ,
3-quinuclidinyloxy-2,2,2-(hydroxy-cylcopentane-phenyl)ethane
unii-353cx8cshd
m-8218
c20h29no2
m 8218
2-(1-azabicyclo[2.2.2]octan-3-yloxy)-1-cyclopentyl-1-phenylethanol
3-(2'-phenyl-2'-cyclopentyl-2'-hydroxyethoxy)quinuclidine
SCHEMBL6920037
penequinine
2-(1-azabicyclo(2.2.2)octan-3-yloxy)-1-cyclopentyl-1-phenylethanol
penequine
benzenemethanol, .alpha.-((1-azabicyclo(2.2.2)oct-3-yloxy)methyl)-.alpha.-cyclopentyl-
penethequinine
p8018
penehyclidine [who-dd]
3-(2-hydroxyl-2-cyclopentyl-2-phenyl-ethoxy) quinuclidine
AKOS030573264
BCP32296
1-cyclopentyl-1-phenyl-2-(quinuclidin-3-yloxy)ethanol
Q27256418
2-[(1-azabicyclo[2.2.2]octan-3-yl)oxy]-1-cyclopentyl-1-phenylethan-1-ol
DTXSID301007814
CHEMBL4594416
HY-142119
penequinine, penehyclidine

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" With the exception of treatment-unrelated abnormality in surface righting reflex in the F1 generation, penequine hydrochloride did not produce any adverse effects at doses up to and including 12."( The pre- and post-natal toxicity of penequine hydrochloride in mice.
Huang, C; Jin, H; Wang, A; Wang, Z; Zhang, Q; Zhang, Z, 2006
)
0.33
" Under the experimental conditions, penequine hydrochloride did not produce any adverse effects (expect the decreases in certain relative organ weights) up to and including 12."( Fertility and early embryonic development toxicity of penequine hydrochloride in mice.
Huang, C; Jin, H; Wang, A; Wang, Z; Zhang, Q; Zhang, Z, 2007
)
0.34
" Tolerability was assessed based on adverse events and clinical laboratory tests."( Safety of the muscarinic receptor-antagonist (R,R)-penehyclidine fumarate in healthy subjects: A phase 1 randomized, double-blind, single-dose escalation study
.
Fu, C; Guo, C; Huang, J; Pei, Q; Yang, G; Yang, S; Yang, X; Zhang, X, 2020
)
0.56

Pharmacokinetics

ExcerptReferenceRelevance
" This method was successfully applied to quantification and pharmacokinetic studies of PH in the subjects."( Determination of penehyclidine by gas chromatographic-mass spectrometry and its application to pharmacokinetics in humans, rabbits and mice.
Liu, K; Qiao, J; Ruan, J; Xu, Y; Xue, M; Yuan, S; Zhang, Z, 2006
)
0.33

Compound-Compound Interactions

ExcerptReferenceRelevance
"To investigate the effects of penehyclidine hydrochloride(PH)/atropine combined with neostigmine for antagonizing residual neuromuscular block on the hemodynamics."( [Effects of penehyclidine hydrochloride or atropine combined with neostigmine for antagonizing residual neuromuscular block on patient's hemodynamics].
Chen, YM; Liang, SW, 2005
)
0.33
"To study the effects of ketamine combined with penehyclidine hydrochloride on the learning and memory abilities and the expression of synaptophysin in the hippocampus CA3 region in the brain of neonatal rats."( [Effect of ketamine combined with penehyclidine hydrochloride on the expression of synaptophysin in the brain of neonatal rats].
Guo, YZ; Lin, L; Zhang, LC, 2010
)
0.36
"Ketamine combined with penehyclidine hydrochloride may inhibit more significantly learning and memory abilities and the synaptophysin expression in the hippocampus CA3 region than ketamine alone in neonatal rats."( [Effect of ketamine combined with penehyclidine hydrochloride on the expression of synaptophysin in the brain of neonatal rats].
Guo, YZ; Lin, L; Zhang, LC, 2010
)
0.36
"This study aimed to observe the clinical curative effect of penehyclidine hydrochloride (PHC) combined with hemoperfusion in treating acute severe organophosphorus pesticide poisoning."( Clinical analysis of penehyclidine hydrochloride combined with hemoperfusion in the treatment of acute severe organophosphorus pesticide poisoning.
Liang, MJ; Zhang, Y, 2015
)
0.42
"To investigate the effects of penehyclidine combined with edaravone on acute cerebral infarction (ACI) in rats."( Curative efficacy of penehyclidine combined with edaravone on acute cerebral infarction and their effects on serum TNF-α and NDS score in rats.
Chen, Y; Zhao, Y, 2018
)
0.48
" After grouping, rats in the treatment groups were treated with edaravone combined with phenecyclidine."( Curative efficacy of penehyclidine combined with edaravone on acute cerebral infarction and their effects on serum TNF-α and NDS score in rats.
Chen, Y; Zhao, Y, 2018
)
0.48
"Penehyclidine combined with edaravone has a better clinical treatment effect on ACI rats, which can significantly reduce the levels of serum TNF-α, IL-6 and HMGB1 and the NDS score, so it is worthy of popularization in clinical application."( Curative efficacy of penehyclidine combined with edaravone on acute cerebral infarction and their effects on serum TNF-α and NDS score in rats.
Chen, Y; Zhao, Y, 2018
)
0.48
"To investigate the effects of penehyclidine hydrochloride combined with dexmedetomidine on pulmonary function in patients undergoing heart valve surgery with cardiopulmonary bypass (CPB)."( Effects of penehyclidine hydrochloride combined with dexmedetomidine on pulmonary function in patients undergoing heart valve surgery: a double-blind, randomized trial.
Chen, Y; He, F; Lu, Y; Mao, Q; Xie, Y; Zhou, L, 2023
)
0.91

Bioavailability

ExcerptReferenceRelevance
"The assay is simple and accurate, with good reproducibility, and can satisfy to the needs of pharmacokinetics and relative bioavailability studies on penehyclidine hydrochloride."( [Detecting penehyclidine hydrochloride in rats plasma and tissues with HPLC-MS/MS].
Liang, MZ; Nan, F; Qin, YP; Xiang, J; Yu, Q, 2010
)
0.36

Dosage Studied

ExcerptRelevanceReference
"19 mg/kg/day in females) corresponding to approximately 72 times above anticipated dosage in human."( Fertility and early embryonic development toxicity of penequine hydrochloride in mice.
Huang, C; Jin, H; Wang, A; Wang, Z; Zhang, Q; Zhang, Z, 2007
)
0.34
" A total of 60 Wistar rats were randomly divided into 4 groups including fake surgery group, model group, low PHC dosage group and high dosage penehvclidine hvdrochloride (PHC) group."( Protective effect of penehvclidine hvdrochloride on ischemia-reperfusion injury in rats.
Cai, W; Su, Z, 2014
)
0.4
"Compared with rats in model group, decreased urine volume, diet volume, Cre, PU, BUN, IL-6, IL-8, TNF-α, NO MDA concentration and increased SOD and GSH-Px activity could be seen in low PHC dosage group and high dosage PHC group (P<0."( Protective effect of penehvclidine hvdrochloride on ischemia-reperfusion injury in rats.
Cai, W; Su, Z, 2014
)
0.4
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (112)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (0.89)18.7374
1990's2 (1.79)18.2507
2000's20 (17.86)29.6817
2010's69 (61.61)24.3611
2020's20 (17.86)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.89

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.89 (24.57)
Research Supply Index4.96 (2.92)
Research Growth Index5.86 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.89)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials24 (20.34%)5.53%
Reviews4 (3.39%)6.00%
Case Studies1 (0.85%)4.05%
Observational0 (0.00%)0.25%
Other89 (75.42%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]