medrogestone has been researched along with Pain* in 2 studies
2 trial(s) available for medrogestone and Pain
Article | Year |
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Cyclic progestin therapy for the management of mastopathy and mastodynia.
The management of benign diseases of the breast aims to halt the progression of fibrocystic transformation and to eliminate the symptoms of pain and breast tenderness. Progestins can be used for this purpose. In a controlled, randomized, double-blind, parallel-group study we treated 31 women with mastopathy/mastodynia with the progestins medrogestone (10 mg/day) or dydrogesterone (10 mg/day) from day 14 to day 25 for six cycles. Before, during and at the end of therapy the following parameters were evaluated: subjective symptoms (pain, tenderness, impairment of daily activities), palpatory findings, sonographic diagnosis and sex hormone profiles. Cyclic administration of the low-dose progestins medrogestone and dydrogesterone proved to be an effective and safe treatment of mastodynia and mastopathy. The objective parameters palpatory findings and sonographic imaging of breast nodules and cysts improved in more than 50% of patients. Improvement was particularly marked in women with low progesterone levels in the second half of the cycle. After six treatment cycles, 75% of the patients treated with dydrogesterone and 86% of the patients treated with medrogestone were completely pain-free. Topics: Adult; Breast Diseases; Double-Blind Method; Dydrogesterone; Estradiol; Female; Fibrocystic Breast Disease; Humans; Luteal Phase; Medrogestone; Menstrual Cycle; Middle Aged; Pain; Palpation; Periodicity; Progesterone; Progestins; Treatment Outcome; Ultrasonography | 2001 |
[The effect of cyclic administration of progestagens on blood coagulation factors].
The relationship between thromboembolism and oral contraceptives has been discussed for 30 years. Recently, a new actuality for this problem has grown up. The estrogen component of the preparations seems to be the cause, but some authors also think of the progestogens as responsible for drug-related thromboembolic disorders. In 31 patients with mastopathy or mastodynia, who had been treated with 10 mg medrogeston of dydrogesteron for six cycles, there were no significant changes in the parameters of hemostasis and fibrinolysis. Especially, we did not find any indications to an activation of the coagulation system. There is no evidence for a thrombogenetic effect caused by the cyclic therapy with these progestogens. Topics: Adolescent; Adult; Blood Coagulation Factors; Breast Diseases; Dydrogesterone; Female; Humans; Medrogestone; Middle Aged; Pain; Pregnancy; Progesterone Congeners | 1998 |