Page last updated: 2024-12-06

f 7302

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

F 7302: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID62279
CHEMBL ID333410
CHEBI ID194294
SCHEMBL ID722133
MeSH IDM0112288

Synonyms (30)

Synonym
bdbm50033531
n-[1-(2-hydroxy-2-phenyl-ethyl)-3-methyl-piperidin-4-yl]-n-phenyl-propionamide
dea no. 9831
propanamide, n-(1-(2-hydroxy-1-methyl-2-phenylethyl)-3-methyl-4-piperidinyl)-n-phenyl-
n-(1-(2-hydroxy-1-methyl-2-phenylethyl)-3-methyl-4-piperidinyl)-n-phenylpropanamide
f 7302
n-(1-(2-hydroxy-2-phenethyl)-3-methyl-4-piperidinyl)-n-phenylpropanamide
f-7302
beta-hydroxy-3-methylfentanyl
ohmefentanyl
omf ,
DB01570
L000454
CHEMBL333410 ,
CHEBI:194294
n-[1-(2-hydroxy-2-phenylethyl)-3-methylpiperidin-4-yl]-n-phenylpropanamide
y8263089zx ,
unii-y8263089zx
78995-14-9
SCHEMBL722133
ids-nb-010(sect.3)
propanamide, n-(1-(2-hydroxy-2-phenylethyl)-3-methyl-4-piperidinyl)-n-phenyl-
n-(1-(2-hydroxy-2- phenethyl)-3-methyl-4-piperidinyl)-n-phenylpropanamide
rti-4614-4
acscn-9831
.beta.-hydroxy-3-methylfentanyl
ids-nb-010
n-(1-(.beta.-hydroxyphenethyl)-3-methyl-4-piperidyl)propionanilide
AKOS030242800
DTXSID50868495

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" The pharmacokinetic characteristics of [3H]OMF in rats was studied in this paper."( [Pharmacokinetics of [3H]ohmefentanyl in rats].
Chi, ZQ; Jin, WQ; Zhao, GM; Zheng, WJ; Zhou, HY, 1990
)
0.28

Dosage Studied

ExcerptRelevanceReference
" Dose-response curves for the enhancement of the two drugs on morphine analgesia were bell-shaped."( [Potentiation of morphine- and ohmefentanyl-induced analgesia by cholecystokinin receptor antagonists in rat].
Han, JS; Sun, YH; Zhou, Y, 1993
)
0.29
" Both devazepide and L-365,260 showed a bell-shaped dose-response curve."( Increased release of immunoreactive cholecystokinin octapeptide by morphine and potentiation of mu-opioid analgesia by CCKB receptor antagonist L-365,260 in rat spinal cord.
Han, JS; Sun, YH; Zhang, ZW; Zhou, Y, 1993
)
0.29
" On the basis of the dose-response curve analysis, ohmefentanyl stereoisomers displayed a significant difference in place preference ED50."( Quantitative comparison of ohmefentanyl isomers induced conditioning place preference in mice.
Chen, XJ; Chi, ZQ; Guo, GW; Jin, WQ; Liu, ZH; Zhang, HP; Zhu, YC, 2001
)
0.31
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
piperidines
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Delta-type opioid receptorMus musculus (house mouse)Ki0.11400.00000.53939.4000AID149093
Mu-type opioid receptorMus musculus (house mouse)Ki0.00000.00000.12281.3000AID151269
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
plasma membraneMu-type opioid receptorMus musculus (house mouse)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID233624Ratio of binding affinity towards delta to mu receptor1995Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
Stereoisomers of N-[1-hydroxy-(2-phenylethyl)-3-methyl-4-piperidyl]- N-phenylpropanamide: synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics.
AID138358Inhibitory effect in isolated tissues of Mouse vas deferens (MVD).1995Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
Stereoisomers of N-[1-hydroxy-(2-phenylethyl)-3-methyl-4-piperidyl]- N-phenylpropanamide: synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics.
AID151269Inhibition against Opioid receptor mu 1 using [3H]- DAMGO radioligand.1995Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
Stereoisomers of N-[1-hydroxy-(2-phenylethyl)-3-methyl-4-piperidyl]- N-phenylpropanamide: synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics.
AID165765Inhibitory effect in isolated tissues of rabbit vas deferens (RVD)1995Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
Stereoisomers of N-[1-hydroxy-(2-phenylethyl)-3-methyl-4-piperidyl]- N-phenylpropanamide: synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics.
AID149093Inhibition against delta-opioid receptor using [3H]DPDPE radioligand.1995Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
Stereoisomers of N-[1-hydroxy-(2-phenylethyl)-3-methyl-4-piperidyl]- N-phenylpropanamide: synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics.
AID118196Analgesic potency was assessed by relative potency with respect to morphine activity(1)1995Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
Stereoisomers of N-[1-hydroxy-(2-phenylethyl)-3-methyl-4-piperidyl]- N-phenylpropanamide: synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics.
AID112190The analgesic potency determined by hot plate test in mice after i.p. administration1995Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
Stereoisomers of N-[1-hydroxy-(2-phenylethyl)-3-methyl-4-piperidyl]- N-phenylpropanamide: synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics.
AID118197Analgesic potency was assessed by relative potency with respect to morphine activity(1).1995Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
Stereoisomers of N-[1-hydroxy-(2-phenylethyl)-3-methyl-4-piperidyl]- N-phenylpropanamide: synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics.
AID79035Inhibitory effect in isolated tissues of guinea pig ileum(GPI).1995Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18
Stereoisomers of N-[1-hydroxy-(2-phenylethyl)-3-methyl-4-piperidyl]- N-phenylpropanamide: synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (64)

TimeframeStudies, This Drug (%)All Drugs %
pre-199014 (21.88)18.7374
1990's36 (56.25)18.2507
2000's12 (18.75)29.6817
2010's2 (3.13)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.24

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.24 (24.57)
Research Supply Index4.20 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.24)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other66 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]