Protein mono-ADP-ribosyltransferase PARP14

A protein mono-ADP-ribosyltransferase PARP14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q460N5]

Synonyms

EC 2.4.2.-;
ADP-ribosyltransferase diphtheria toxin-like 8;
ARTD8;
B aggressive lymphoma protein 2;
Poly [ADP-ribose] polymerase 14;
PARP-14

Research

Bioassay Publications (4)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (75.00)	24.3611
2020's	1 (25.00)	2.80

Compounds (7)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
pj-34	Homo sapiens (human)	IC50	4.1843	1	2
4-Methoxybenzamide	Homo sapiens (human)	IC50	10.0000	1	1
rucaparib	Homo sapiens (human)	IC50	8.8713	1	2
veliparib	Homo sapiens (human)	IC50	89.0626	1	2
niraparib	Homo sapiens (human)	IC50	9.5189	1	2
xav939	Homo sapiens (human)	IC50	5.6001	2	3

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
rucaparib	Homo sapiens (human)	Kd	10.0000	1	1
niraparib	Homo sapiens (human)	Kd	10.0000	1	1
bmn 673	Homo sapiens (human)	Kd	10.0000	1	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
NAD+ ADP-ribosyltransferase activity	molecular function	Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. [EC:2.4.2.30]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
nucleotidyltransferase activity	molecular function	Catalysis of the transfer of a nucleotidyl group to a reactant. [ISBN:0198506732]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
NAD+-protein ADP-ribosyltransferase activity	molecular function	Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide. [PMID:1899243]
transcription corepressor activity	molecular function	A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Involved In

This protein is involved in 8 target(s):

Target	Category	Definition
negative regulation of gene expression	biological process	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
positive regulation of tyrosine phosphorylation of STAT protein	biological process	Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. [GOC:jl, PMID:11426647]
negative regulation of tyrosine phosphorylation of STAT protein	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. [GOC:jl, PMID:11426647]
innate immune response	biological process	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
negative regulation of DNA-templated transcription	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
negative regulation of type II interferon-mediated signaling pathway	biological process	Any process that decreases the rate, frequency or extent of an interferon-gamma-mediated signaling pathway. [GOC:dph]
positive regulation of interleukin-4-mediated signaling pathway	biological process	Any process that activates or increases the frequency, rate or extent of interleukin-4-mediated signaling pathway. [GOC:TermGenie, PMID:17210636]
protein poly-ADP-ribosylation	biological process	The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain. [GOC:BHF, GOC:mah, GOC:rl, PMID:25043379]