coumatetralyl

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

coumatetralyl: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	54678504
CHEMBL ID	3184636
CHEBI ID	80742
SCHEMBL ID	5933927
SCHEMBL ID	137261
MeSH ID	M0045840

Synonyms (67)

Synonym
AC-12689
racumin
coumarin, 4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthyl)-
einecs 227-424-0
bayer 25 634
endox
raucumin 57
2h-1-benzopyran-2-one, 4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-
coumatetralyl [bsi:iso]
epa pesticide chemical code 496100
rodentin
ccris 6923
bay 25634
cumatetralyl [german, dutch]
endrocide
3-(d-tetralyl)-4-hydroxycoumarin
4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthyl)coumarin
3-(alpha-tetralyl)-4-hydroxycoumarin
3-(1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycumarin [german]
4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthyl)-cumarin
bay ene 11183 b
4-idrossi-3-(1,2,3,4-tetraidro-1-naftil)-cumarina [italian]
coumatetralyl
brn 1323631
4-hydroxy-3-(1,2,3,4-tetrahydro-1-naftyl)-cumarine [dutch]
hsdb 1725
4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-2h-1-benzopyran-2-one
3-(1,2,3,4-tetrahydro-1-naphtyl)-4-hydroxycoumarine [french]
ene 11183 b
3-(alpha-tetral)-4-oxycoumarin
caswell no. 496a
endrocid
5836-29-3
dtxsid8041799 ,
NCGC00255682-01
cas-5836-29-3
tox21_301252
dtxcid6021799
4-idrossi-3-(1,2,3,4-tetraidro-1-naftil)-cumarina
unii-nwk4hw86a8
3-(1,2,3,4-tetrahydro-1-naphtyl)-4-hydroxycoumarine
4-hydroxy-3-(1,2,3,4-tetrahydro-1-naftyl)-cumarine
cumatetralyl
3-(1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycumarin
nwk4hw86a8 ,
3-(1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycoumarin
AKOS015903266
SCHEMBL5933927
SCHEMBL137261
coumatetralyl [hsdb]
3-(.alpha.-tetralyl)-4-hydroxycoumarin
2h-1-benzopyran-2-one, 4-hydroxy-3-(1,2,3,4-tetrahydro-1- naphthalenyl)-
4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-2h-1- benzopyran-2-one
3-(.alpha.-tetral)-4-oxycoumarin
coumatetralyl [iso]
CHEBI:80742 ,
3-(1-tetralyl)-4-hydroxycoumarin
4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-2h-chromen-2-one #
ULSLJYXHZDTLQK-UHFFFAOYSA-N
coumetralyl
3-(1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycoumarine
3-(.alpha.-tetralinyl)-4-hydroxycoumarin
CHEMBL3184636
4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)-2h-chromen-2-one
coumatetralyl, pestanal(r), analytical standard
Q415772
4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
hydroxycoumarin	Any coumarin carrying at least one hydroxy substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (10)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Luciferase	Photinus pyralis (common eastern firefly)	Potency	79.6407	0.0072	15.7588	89.3584	AID1224835
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	48.5577	0.0060	38.0041	19,952.5996	AID1159521; AID1159523
GLI family zinc finger 3	Homo sapiens (human)	Potency	2.1690	0.0007	14.5928	83.7951	AID1259369
AR protein	Homo sapiens (human)	Potency	48.9662	0.0002	21.2231	8,912.5098	AID743035; AID743063
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	58.4254	0.0015	30.6073	15,848.9004	AID1224841; AID1224842; AID1224848; AID1224849; AID1259401; AID1259403
pregnane X nuclear receptor	Homo sapiens (human)	Potency	30.6379	0.0054	28.0263	1,258.9301	AID1346982
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	61.6448	0.0002	29.3054	16,493.5996	AID743069
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	11.3910	0.0010	19.4141	70.9645	AID743094; AID743140; AID743191
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	61.1306	0.0003	23.4451	159.6830	AID743065; AID743067
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	61.1306	0.0006	27.2152	1,122.0200	AID743202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	6 (28.57)	18.7374
1990's	3 (14.29)	18.2507
2000's	5 (23.81)	29.6817
2010's	7 (33.33)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 32.65

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	32.65 (24.57)
Research Supply Index	3.18 (2.92)
Research Growth Index	4.63 (4.65)
Search Engine Demand Index	80.73 (26.88)
Search Engine Supply Index	3.97 (0.95)

This Compound (32.65)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	3 (13.04%)	4.05%
Observational	0 (0.00%)	0.25%
Other	20 (86.96%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
phenindione Phenindione: An indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)	2	1	aromatic ketone; beta-diketone	anticoagulant
diphenadione diphenadione: major descriptor (66-86); on-line search PHENINDIONE (66-74); PHENINDIONE/AA (75-86); INDEX MEDICUS search DIPHENADIONE (66-86); RN given refers to parent cpd	2	1	beta-triketone; diarylmethane
chlorophacinone chlorophacinone: structure	2	1	beta-triketone; diarylmethane
vitamin k semiquinone radical vitamin K semiquinone radical: found in active preparations of vitamin K-dependent carboxylase. vitamin K : Any member of a group of fat-soluble 2-methyl-1,4-napthoquinones that exhibit biological activity against vitamin K deficiency. Vitamin K is required for the synthesis of prothrombin and certain other blood coagulation factors.	2.02	1
vitamin d 2 Ergocalciferols: Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24.. vitamin D2 : A vitamin D supplement and has been isolated from alfalfa.	1.96	1	hydroxy seco-steroid; seco-ergostane; vitamin D	bone density conservation agent; nutraceutical; plant metabolite; rodenticide
cholecalciferol Cholecalciferol: Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.. calciol : A hydroxy seco-steroid that is (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene in which the pro-S hydrogen at position 3 has been replaced by a hydroxy group. It is the inactive form of vitamin D3, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.	7.15	1	D3 vitamins; hydroxy seco-steroid; seco-cholestane; secondary alcohol; steroid hormone	geroprotector; human metabolite
difenacoum diphenacoum: structure in first source	3.08	5	benzenes; naphthalenes; ring assembly
warfarin Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.	3.87	12	benzenes; hydroxycoumarin; methyl ketone
ferulenol ferulenol: intoxicating component of powdered Ferula communis variety brevifolia; RN given for (E,E)-isomer	2.13	1
bromadiolone [no description available]	8.53	8	diarylheptanoid
bromfenacoum [no description available]	3.24	6	benzenes; naphthalenes; ring assembly
coumachlor coumachlor: C19-H15-Cl-O4	2.13	1	hydroxycoumarin
flocoumafen [no description available]	2.77	3	benzenes; naphthalenes; ring assembly

Condition	Relationship Strength	Studies
Bleeding [description not available]	2.41	2
Ache [description not available]	2.02	1
Hemorrhage Bleeding or escape of blood from a vessel.	2.41	2
Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	2.02	1
Poisoning Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.	2.41	2
Canine Diseases [description not available]	2.06	1
Chylopericardium [description not available]	2.06	1
Pericardial Effusion Fluid accumulation within the PERICARDIUM. Serous effusions are associated with pericardial diseases. Hemopericardium is associated with trauma. Lipid-containing effusion (chylopericardium) results from leakage of THORACIC DUCT. Severe cases can lead to CARDIAC TAMPONADE.	7.06	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.03	1
Avian Diseases [description not available]	2	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	1.95	1

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