Compounds > coumatetralyl
Page last updated: 2024-11-13

coumatetralyl

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

coumatetralyl: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID54678504
CHEMBL ID3184636
CHEBI ID80742
SCHEMBL ID5933927
SCHEMBL ID137261
MeSH IDM0045840

Synonyms (67)

Synonym
AC-12689
racumin
coumarin, 4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthyl)-
einecs 227-424-0
bayer 25 634
endox
raucumin 57
2h-1-benzopyran-2-one, 4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-
coumatetralyl [bsi:iso]
epa pesticide chemical code 496100
rodentin
ccris 6923
bay 25634
cumatetralyl [german, dutch]
endrocide
3-(d-tetralyl)-4-hydroxycoumarin
4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthyl)coumarin
3-(alpha-tetralyl)-4-hydroxycoumarin
3-(1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycumarin [german]
4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthyl)-cumarin
bay ene 11183 b
4-idrossi-3-(1,2,3,4-tetraidro-1-naftil)-cumarina [italian]
coumatetralyl
brn 1323631
4-hydroxy-3-(1,2,3,4-tetrahydro-1-naftyl)-cumarine [dutch]
hsdb 1725
4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-2h-1-benzopyran-2-one
3-(1,2,3,4-tetrahydro-1-naphtyl)-4-hydroxycoumarine [french]
ene 11183 b
3-(alpha-tetral)-4-oxycoumarin
caswell no. 496a
endrocid
5836-29-3
dtxsid8041799 ,
NCGC00255682-01
cas-5836-29-3
tox21_301252
dtxcid6021799
4-idrossi-3-(1,2,3,4-tetraidro-1-naftil)-cumarina
unii-nwk4hw86a8
3-(1,2,3,4-tetrahydro-1-naphtyl)-4-hydroxycoumarine
4-hydroxy-3-(1,2,3,4-tetrahydro-1-naftyl)-cumarine
cumatetralyl
3-(1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycumarin
nwk4hw86a8 ,
3-(1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycoumarin
AKOS015903266
SCHEMBL5933927
SCHEMBL137261
coumatetralyl [hsdb]
3-(.alpha.-tetralyl)-4-hydroxycoumarin
2h-1-benzopyran-2-one, 4-hydroxy-3-(1,2,3,4-tetrahydro-1- naphthalenyl)-
4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-2h-1- benzopyran-2-one
3-(.alpha.-tetral)-4-oxycoumarin
coumatetralyl [iso]
CHEBI:80742 ,
3-(1-tetralyl)-4-hydroxycoumarin
4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-2h-chromen-2-one #
ULSLJYXHZDTLQK-UHFFFAOYSA-N
coumetralyl
3-(1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycoumarine
3-(.alpha.-tetralinyl)-4-hydroxycoumarin
CHEMBL3184636
4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)-2h-chromen-2-one
coumatetralyl, pestanal(r), analytical standard
Q415772
4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
hydroxycoumarinAny coumarin carrying at least one hydroxy substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (10)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency79.64070.007215.758889.3584AID1224835
RAR-related orphan receptor gammaMus musculus (house mouse)Potency48.55770.006038.004119,952.5996AID1159521; AID1159523
GLI family zinc finger 3Homo sapiens (human)Potency2.16900.000714.592883.7951AID1259369
AR proteinHomo sapiens (human)Potency48.96620.000221.22318,912.5098AID743035; AID743063
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency58.42540.001530.607315,848.9004AID1224841; AID1224842; AID1224848; AID1224849; AID1259401; AID1259403
pregnane X nuclear receptorHomo sapiens (human)Potency30.63790.005428.02631,258.9301AID1346982
estrogen nuclear receptor alphaHomo sapiens (human)Potency61.64480.000229.305416,493.5996AID743069
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency11.39100.001019.414170.9645AID743094; AID743140; AID743191
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency61.13060.000323.4451159.6830AID743065; AID743067
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency61.13060.000627.21521,122.0200AID743202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (28.57)18.7374
1990's3 (14.29)18.2507
2000's5 (23.81)29.6817
2010's7 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 32.65

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index32.65 (24.57)
Research Supply Index3.18 (2.92)
Research Growth Index4.63 (4.65)
Search Engine Demand Index80.73 (26.88)
Search Engine Supply Index3.97 (0.95)

This Compound (32.65)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies3 (13.04%)4.05%
Observational0 (0.00%)0.25%
Other20 (86.96%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
phenindione
Phenindione: An indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)		210aromatic ketone;
beta-diketone		anticoagulant
diphenadione
diphenadione: major descriptor (66-86); on-line search PHENINDIONE (66-74); PHENINDIONE/AA (75-86); INDEX MEDICUS search DIPHENADIONE (66-86); RN given refers to parent cpd		210beta-triketone;
diarylmethane
chlorophacinone
chlorophacinone: structure		210beta-triketone;
diarylmethane
vitamin k semiquinone radical
vitamin K semiquinone radical: found in active preparations of vitamin K-dependent carboxylase. vitamin K : Any member of a group of fat-soluble 2-methyl-1,4-napthoquinones that exhibit biological activity against vitamin K deficiency. Vitamin K is required for the synthesis of prothrombin and certain other blood coagulation factors.		2.0210
vitamin d 2
Ergocalciferols: Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24.. vitamin D2 : A vitamin D supplement and has been isolated from alfalfa.		1.9610hydroxy seco-steroid;
seco-ergostane;
vitamin D		bone density conservation agent;
nutraceutical;
plant metabolite;
rodenticide
cholecalciferol
Cholecalciferol: Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.. calciol : A hydroxy seco-steroid that is (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene in which the pro-S hydrogen at position 3 has been replaced by a hydroxy group. It is the inactive form of vitamin D3, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.		7.1510D3 vitamins;
hydroxy seco-steroid;
seco-cholestane;
secondary alcohol;
steroid hormone		geroprotector;
human metabolite
difenacoum
diphenacoum: structure in first source		3.0850benzenes;
naphthalenes;
ring assembly
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		3.87120benzenes;
hydroxycoumarin;
methyl ketone
ferulenol
ferulenol: intoxicating component of powdered Ferula communis variety brevifolia; RN given for (E,E)-isomer		2.1310
bromadiolone
[no description available]		8.5380diarylheptanoid
bromfenacoum
[no description available]		3.2460benzenes;
naphthalenes;
ring assembly
coumachlor
coumachlor: C19-H15-Cl-O4		2.1310hydroxycoumarin
flocoumafen
[no description available]		2.7730benzenes;
naphthalenes;
ring assembly
ConditionIndicatedRelationship StrengthStudiesTrials
Bleeding
[description not available]		02.4120
Ache
[description not available]		02.0210
Hemorrhage
Bleeding or escape of blood from a vessel.		02.4120
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.		02.0210
Poisoning
Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.		02.4120
Canine Diseases
[description not available]		02.0610
Chylopericardium
[description not available]		02.0610
Pericardial Effusion
Fluid accumulation within the PERICARDIUM. Serous effusions are associated with pericardial diseases. Hemopericardium is associated with trauma. Lipid-containing effusion (chylopericardium) results from leakage of THORACIC DUCT. Severe cases can lead to CARDIAC TAMPONADE.		07.0610
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0310
Avian Diseases
[description not available]		0210
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		01.9510