guttiferone-a and Pain

guttiferone-a has been researched along with Pain* in 1 studies

Other Studies

1 other study(ies) available for guttiferone-a and Pain

ArticleYear
Phytochemical analysis and antinociceptive properties of the seeds of Garcinia achachairu.
    Archives of pharmacal research, 2012, Volume: 35, Issue:4

    In a search for new and effective analgesic substances from the Brazilian biodiversity, the present study evaluates the chemical composition and antinociceptive potential of the methanol extract and a pure compound obtained from the seeds of Garcinia achachairu Rusby (Clusiaceae). The methanolic seed extract was directly subjected to purification by column chromatography and the purification was monitored by thin-layer chromatography. The main isolated compound was identified as Guttiferone A by comparison of conventional spectroscopic data (IR, NMR-(1)H and (13)C) to the literature data which was isolated for the first time from this plant. When evaluated in the acetic acid-induced nociception model in mice, the methanolic seed extract had an ID(50) (Inhibitory dose) of 13.1 (11.23-14.91) mg/kg and a maximal inhibition of 72 ± 4%. In the same model, Guttiferone A had an ID(50) of 4.54 (3.29-6.24) mg/kg and a maximal inhibition of 73 ± 5%. The methanolic seed extract and Guttiferone A were also active in pain models induced by formalin, capsaicin, glutamate and carrageenan. These data suggest that the antinociceptive effect of Guttiferone A partly depends on its interference with the synthesis or activity of the cytokine TNF-α, the keratinocyte-derived chemokine KC, and/or PGE(2). These data support, at least in part, the use of G. achachairu in folk medicine and suggest that this plant is an important source of compounds with a suitable profile for development as new and effective medicinal agents to treat pain processes.

    Topics: Analgesics, Non-Narcotic; Animals; Benzophenones; Chromatography, Thin Layer; Disease Models, Animal; Dose-Response Relationship, Drug; Garcinia; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Structure; Pain; Pain Measurement; Seeds

2012