tolmetin and Pain
tolmetin has been researched along with Pain in 93 studies
Tolmetin: A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.
tolmetin : A monocarboxylic acid that is (1-methylpyrrol-2-yl)acetic acid substituted at position 5 on the pyrrole ring by a 4-methylbenzoyl group. Used in the form of its sodium salt dihydrate as a nonselective nonsteroidal anti-inflammatory drug.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients receiving ketorolac and those receiving placebo were of similar age, weight, gender, number of prior ED visits, number of prior hospital admissions, duration of pain prior to presentation, and initial pain score." | 9.09 | Effect of ketorolac in pediatric sickle cell vaso-occlusive pain crisis. ( Givens, TG; Hardwick, WE; King, WD; Lawley, D; Monroe, KW, 1999) |
| "A randomised, double-blind, controlled trial was undertaken to compare three different methods of reducing pain during the intravenous injection of propofol." | 9.08 | The effect of pretreatment with ketorolac on pain during intravenous injection of propofol. ( Power, I; Smith, AJ, 1996) |
| "IM ketorolac and oral ibuprofen provide comparable analgesia in ED patients with acute musculoskeletal pain." | 9.08 | Intramuscular ketorolac versus oral ibuprofen in acute musculoskeletal pain. ( Paris, PM; Seaberg, DC; Turturro, MA, 1995) |
| "To determine whether postoperative pain and nausea after laparoscopic sterilization can be reduced with a combination of bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning." | 9.08 | Reduction of pain and nausea after laparoscopic sterilization with bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning. ( Bradford, TH; Meeks, GR; Norman, PF; Robertson, K, 1995) |
| "Propofol, which is commonly used for outpatient anaesthesia, may evoke pain during infusion." | 9.08 | Prilocaine reduces injection pain caused by propofol. ( Eriksson, M, 1995) |
| "25% bupivacaine without epinephrine to those of normal saline on chest tube removal pain in cardiothoracic surgery patients." | 9.08 | Effects of interpleural bupivacaine on pleural chest tube removal pain: a randomized controlled trial. ( Puntillo, KA, 1996) |
| " Subjects were administered meperidine on presentation and then received a standardized dose of meperidine every 30 minutes during the four-hour observation period based on the severity of pain." | 9.07 | Ketorolac for sickle cell vaso-occlusive crisis pain in the emergency department: lack of a narcotic-sparing effect. ( Mitchell, TR; Norris, RL; Wright, SW, 1992) |
| "An open, multi-centre study was carried out in patients with various moderate to severe painful conditions to assess the effectiveness of zomepirac in relieving pain." | 9.05 | A multi-centre study of zomepirac in painful conditions: an analysis of clinical data for 15,484 patients. ( Jefferson, WL; Steele, CE, 1983) |
| "We investigated the antinociceptive properties of dexketoprofen trometamol [S(+)-ketoprofen tromethamine salt; SKP], a new analgesic, antiinflammatory drug, using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain." | 7.70 | Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid. ( Cabré, F; Díaz, I; Fernández-Guasti, A; López-Muñoz, FJ; Mauleón, D; Tost, D; Ventura, R, 1998) |
| "To report a case in which intravenous ketorolac was used successfully on a chronic basis to treat cancer pain." | 7.68 | Pain management with intravenous ketorolac. ( Kramer, MA; Miller, LJ, 1993) |
| " Patients were allocated at random to treatment with either 800 mg tolmetin sodium daily or 500 mg naproxen daily over a period of 12 weeks, both drugs being given in identical capsule form in a dosage of 2 capsules twice daily." | 6.65 | A double-blind comparative evaluation of tolmetin versus naproxen in osteoarthritis. ( Bach-Andersen, R; Persson, B; Telhag, H, 1981) |
| " The incidence of serious or fatal adverse events reported with ketorolac has decreased since revision of dosage guidelines." | 6.40 | Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management. ( Brogden, RN; Gillis, JC, 1997) |
| "Pain was quantified in 6 of the patients using a 10-cm visual analog scale that the patients completed before and 30, 60, and 90 minutes after ketorolac administration." | 5.29 | Treatment of acute gouty arthritis with intramuscular ketorolac tromethamine. ( Chiu, MJ; Cush, JJ; Martin, RL; Shrestha, M; Wainscott, MS, 1994) |
| "A 21-year-old woman with systemic lupus erythematosus (SLE) had meningismus, conjunctivitis, lymphadenopathy, and elevation of liver function values following ibuprofen therapy." | 5.26 | Tolmetin-induced aseptic meningitis. ( Barth, WF; Ruppert, GB, 1981) |
| "Patients receiving ketorolac and those receiving placebo were of similar age, weight, gender, number of prior ED visits, number of prior hospital admissions, duration of pain prior to presentation, and initial pain score." | 5.09 | Effect of ketorolac in pediatric sickle cell vaso-occlusive pain crisis. ( Givens, TG; Hardwick, WE; King, WD; Lawley, D; Monroe, KW, 1999) |
| "Propofol, which is commonly used for outpatient anaesthesia, may evoke pain during infusion." | 5.08 | Prilocaine reduces injection pain caused by propofol. ( Eriksson, M, 1995) |
| "We studied the comparative effects of ketorolac versus bupivacaine supplementation of hydromorphone (HM) patient-controlled epidural analgesia (PCEA) on the HM requirement, postoperative pain, and pulmonary function in 62 consenting patients after thoracotomy procedures." | 5.08 | Effects of ketorolac versus bupivacaine coadministration during patient-controlled hydromorphone epidural analgesia after thoracotomy procedures. ( Bossard, RF; Singh, H; White, PF; Yeatts, RW, 1997) |
| "IM ketorolac and oral ibuprofen provide comparable analgesia in ED patients with acute musculoskeletal pain." | 5.08 | Intramuscular ketorolac versus oral ibuprofen in acute musculoskeletal pain. ( Paris, PM; Seaberg, DC; Turturro, MA, 1995) |
| "To determine whether postoperative pain and nausea after laparoscopic sterilization can be reduced with a combination of bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning." | 5.08 | Reduction of pain and nausea after laparoscopic sterilization with bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning. ( Bradford, TH; Meeks, GR; Norman, PF; Robertson, K, 1995) |
| "A randomised, double-blind, controlled trial was undertaken to compare three different methods of reducing pain during the intravenous injection of propofol." | 5.08 | The effect of pretreatment with ketorolac on pain during intravenous injection of propofol. ( Power, I; Smith, AJ, 1996) |
| "25% bupivacaine without epinephrine to those of normal saline on chest tube removal pain in cardiothoracic surgery patients." | 5.08 | Effects of interpleural bupivacaine on pleural chest tube removal pain: a randomized controlled trial. ( Puntillo, KA, 1996) |
| "While it appears that ketorolac provides a better postoperative course than either IM or PCA morphine in terms of pain control, postoperative confusion, length of stay, and duration of ileus, 18% of our patients assigned to ketorolac required additional analgesia, and there was a strong patient preference for PCA." | 5.08 | Does patient-controlled analgesia achieve better control of pain and fewer adverse effects than intramuscular analgesia? A prospective randomized trial. ( Avecilla, CS; Berg, RL; Nitschke, LF; Schlösser, CT; Selthafner, JV; Wengert, TJ, 1996) |
| " Subjects were administered meperidine on presentation and then received a standardized dose of meperidine every 30 minutes during the four-hour observation period based on the severity of pain." | 5.07 | Ketorolac for sickle cell vaso-occlusive crisis pain in the emergency department: lack of a narcotic-sparing effect. ( Mitchell, TR; Norris, RL; Wright, SW, 1992) |
| "In a double-blind, placebo-controlled study the efficacy and safety of topical ketorolac tromethamine were assessed in the reduction of inflammation and pain due to ankle sprain." | 5.06 | A double-blind study of the efficacy of topical ketorolac tromethamine gel in the treatment of ankle sprain, in comparison to placebo and etofenamate. ( Bullingham, R; Diebschlag, W; Nocker, W, 1990) |
| "In a controlled double blind study the therapeutic efficacy and tolerability of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-acetoxy] acetic acid (acemetacin, TV 1322, Rantudil¿) and tolmetin were compared in 40 patients suffering from acute and subacute painful irritant conditions in the spinal area and joints." | 5.05 | [Comparison of the therapeutic efficacy and tolerability of acemetacin and tolmetin (author's transl)]. ( Handrich, L, 1980) |
| " For occasional moderate pain not responsive to aspirin, zomepirac may prove to be preferable to oral narcotics such as codeine, oxycodone, propoxyphene, pentazocine and meperidine." | 5.05 | Zomepirac sodium -- a new oral analgesic. ( , 1981) |
| "An open, multi-centre study was carried out in patients with various moderate to severe painful conditions to assess the effectiveness of zomepirac in relieving pain." | 5.05 | A multi-centre study of zomepirac in painful conditions: an analysis of clinical data for 15,484 patients. ( Jefferson, WL; Steele, CE, 1983) |
| "We investigated the antinociceptive properties of dexketoprofen trometamol [S(+)-ketoprofen tromethamine salt; SKP], a new analgesic, antiinflammatory drug, using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain." | 3.70 | Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid. ( Cabré, F; Díaz, I; Fernández-Guasti, A; López-Muñoz, FJ; Mauleón, D; Tost, D; Ventura, R, 1998) |
| "To compare the clinical efficacy of single doses of intramuscular ketorolac and oral ibuprofen in the emergency department (ED) treatment of acute pain." | 3.69 | NSAID use and efficacy in the emergency department: single doses of oral ibuprofen versus intramuscular ketorolac. ( Price, SD; Watson, WA; Wright, JM, 1994) |
| "The study compared analgesic efficacy of intrathecally administered ketorolac tromethamine (K) and morphine hydrochloride (M) (in equimolar doses) in the chronic neuropathic pain model, induced by chronic constriction injury (CCI) of the sciatic nerve in rat." | 3.69 | Intrathecal ketorolac tromethamine produces analgesia after chronic constriction injury of sciatic nerve in rat. ( Horn, JL; Janicki, PK; Johnson, B; Parris, WC, 1996) |
| "To report a case in which intravenous ketorolac was used successfully on a chronic basis to treat cancer pain." | 3.68 | Pain management with intravenous ketorolac. ( Kramer, MA; Miller, LJ, 1993) |
| "Zomepirac sodium is a new nonsteroidal anti-inflammatory agent for management of mild to moderate pain." | 3.66 | Zomepirac-induced renal failure. ( Lacher, JW; Miller, FC; Schorr, WJ, 1983) |
| "Zomepirac sodium inhibited the reflex hypertension caused by an injection of bradykinin into the splenic artery of anaesthetized dogs, but not that by injection of bradykinin plus PGE1." | 3.66 | Site of analgesic action of zomepirac sodium, a potent non-narcotic analgesic in experimental animals. ( Imazu, C; Ishii, K; Kadokawa, T; Nakamura, H; Shimizu, M; Yokoyama, Y, 1983) |
| "Ketorolac tromethamine (Toradol) is a parenteral, nonsteroidal antiinflammatory drug that is being extensively used to provide postoperative analgesia." | 2.68 | Intraoperative ketorolac has an opioid-sparing effect in women after diagnostic laparoscopy but not after laparoscopic tubal ligation. ( Green, CR; Kothary, SP; Levy, L; Pandit, SK; Schork, MA; Tait, AR, 1996) |
| "Treating traumatic corneal abrasions is a common problem for the ophthalmologist." | 2.68 | Controlled evaluation of a bandage contact lens and a topical nonsteroidal anti-inflammatory drug in treating traumatic corneal abrasions. ( Cohen, AJ; Donnenfeld, ED; Moadel, K; Perry, HD; Selkin, BA; Selkin, GT; Sperber, LT, 1995) |
| "Ketorolac tromethamine is a newly available non-steroidal anti-inflammatory drug which is suitable for parenteral administration." | 2.67 | Use of ketorolac by continuous subcutaneous infusion for the control of cancer-related pain. ( Myers, KG; Trotman, IF, 1994) |
| "Ketorolac appears to be a safe and effective therapy for children when given in appropriate doses for a limited duration." | 2.67 | Clinical experience with ketorolac in children. ( Buck, ML, 1994) |
| " Patients were allocated at random to treatment with either 800 mg tolmetin sodium daily or 500 mg naproxen daily over a period of 12 weeks, both drugs being given in identical capsule form in a dosage of 2 capsules twice daily." | 2.65 | A double-blind comparative evaluation of tolmetin versus naproxen in osteoarthritis. ( Bach-Andersen, R; Persson, B; Telhag, H, 1981) |
| "Pain is traditionally measured in analgesic studies by employing verbal descriptors of intensity, but more recently visual analogues of pain intensity have been used and generally provide more sensitive measures of pain intensity." | 2.65 | Measurement of pain and analgesia in cancer patients. ( Wallenstein, SL, 1984) |
| " The incidence of serious or fatal adverse events reported with ketorolac has decreased since revision of dosage guidelines." | 2.40 | Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management. ( Brogden, RN; Gillis, JC, 1997) |
| "Zomepirac is an analgesic which is closely related chemically to the nonsteroidal anti-inflammatory agent, tolmetin." | 2.36 | Zomepirac: a review of its pharmacological properties and analgesic efficacy. ( Avery, GS; Brogden, RN; Carmine, AA; Heel, RC; Morley, PA; Speight, TM, 1982) |
| "Pain was quantified in 6 of the patients using a 10-cm visual analog scale that the patients completed before and 30, 60, and 90 minutes after ketorolac administration." | 1.29 | Treatment of acute gouty arthritis with intramuscular ketorolac tromethamine. ( Chiu, MJ; Cush, JJ; Martin, RL; Shrestha, M; Wainscott, MS, 1994) |
| "The pressor response to noxious colorectal distention (80 mmHg, 20 s) was evaluated in 29 male Sprague-Dawley rats and dose-response curves were determined for intravenous morphine, ketorolac and the mixture of morphine and ketorolac." | 1.29 | Ketorolac potentiates morphine antinociception during visceral nociception in the rat. ( Gebhart, GF; Maves, TJ; Meller, ST; Pechman, PS, 1994) |
| "The gene for sickle cell disease is carried by 8% of the African-American population in the United States." | 1.28 | Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department. ( Pollack, CV; Sanders, DY; Severance, HW, 1992) |
| "Ketorolac tromethamine is a highly potent member of a class of compounds having both analgesic and antiinflammatory activity." | 1.28 | The pharmacologic activity of ketorolac tromethamine. ( Rooks, WH, 1990) |
| "A 21-year-old woman with systemic lupus erythematosus (SLE) had meningismus, conjunctivitis, lymphadenopathy, and elevation of liver function values following ibuprofen therapy." | 1.26 | Tolmetin-induced aseptic meningitis. ( Barth, WF; Ruppert, GB, 1981) |
| "2 Tolmetin sodium was administered to the rat between 15 and 60 min after intraperitoneal injection of 1 ml of a 1% acetic acid aqueous solution." | 1.26 | Site of analgesic action of a non-steroidal, anti-inflammatory drug, tolmetin sodium, in rats. ( Nakamura, H; Shimizu, M, 1981) |
| "Zomepirac appears to be an unexpectedly effective oral, non-opioid analgesic." | 1.26 | Clinical analgesic assay of oral zomepirac and intramuscular morphine. ( Heidrich, G; Houde, RW; Kaiko, RF; Rogers, A; Wallenstein, SL, 1979) |
Research
Studies (93)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (37.63) | 18.7374 |
| 1990's | 58 (62.37) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Steele, CE | 2 |
| Jefferson, WL | 1 |
| Miller, FC | 1 |
| Schorr, WJ | 1 |
| Lacher, JW | 1 |
| Cooper, SA | 1 |
| Wallenstein, SL | 2 |
| Schady, W | 1 |
| Torebjörk, HE | 1 |
| Nakamura, H | 2 |
| Imazu, C | 1 |
| Ishii, K | 1 |
| Yokoyama, Y | 1 |
| Kadokawa, T | 1 |
| Shimizu, M | 2 |
| Creasy, GW | 1 |
| Kousen, M | 1 |
| Walker, WR | 1 |
| Lisker, WH | 1 |
| Kiani, R | 1 |
| Kushner, M | 1 |
| Warren, SE | 1 |
| Mosley, C | 1 |
| Mar, DD | 1 |
| Gever, LN | 1 |
| Houde, RW | 2 |
| Braun, H | 1 |
| Cenarruzabeitia, E | 1 |
| Lasheras, B | 1 |
| Fontan, JL | 1 |
| Rooks, WH | 2 |
| Tomolonis, AJ | 1 |
| Maloney, PJ | 1 |
| Wallach, MB | 1 |
| Schuler, ME | 1 |
| Stambaugh, JE | 1 |
| Tejada, F | 1 |
| Trudnowski, RJ | 1 |
| Mayer, TG | 1 |
| Ruoff, GE | 1 |
| Davies, J | 1 |
| Dixon, AS | 1 |
| Telhag, H | 1 |
| Bach-Andersen, R | 1 |
| Persson, B | 1 |
| Morley, PA | 1 |
| Brogden, RN | 2 |
| Carmine, AA | 1 |
| Heel, RC | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| van Thiel, D | 2 |
| Gorder, JW | 1 |
| Smith, VT | 1 |
| Theron, F | 1 |
| Handrich, L | 1 |
| Ruppert, GB | 1 |
| Barth, WF | 1 |
| Reuben, SS | 1 |
| Steinberg, RB | 1 |
| Kreitzer, JM | 1 |
| Duprat, KM | 1 |
| Turturro, MA | 1 |
| Paris, PM | 1 |
| Seaberg, DC | 1 |
| Negus, SS | 1 |
| Butelman, ER | 1 |
| Gatch, MB | 1 |
| Woods, JH | 1 |
| Turner, DM | 1 |
| Warson, JS | 1 |
| Wirt, TC | 1 |
| Scalley, RD | 1 |
| Cochran, RS | 1 |
| Miller, KJ | 1 |
| Bradford, TH | 1 |
| Robertson, K | 1 |
| Norman, PF | 1 |
| Meeks, GR | 1 |
| Donnenfeld, ED | 1 |
| Selkin, BA | 1 |
| Perry, HD | 1 |
| Moadel, K | 1 |
| Selkin, GT | 1 |
| Cohen, AJ | 1 |
| Sperber, LT | 1 |
| Eriksson, M | 1 |
| Buck, ML | 1 |
| Leeson-Payne, CG | 1 |
| Nicoll, JM | 1 |
| Hobbs, GJ | 1 |
| Chellman, GJ | 1 |
| Lollini, LO | 1 |
| Dorr, AE | 1 |
| DePass, LR | 1 |
| Myers, KG | 1 |
| Trotman, IF | 1 |
| Maves, TJ | 1 |
| Pechman, PS | 1 |
| Meller, ST | 1 |
| Gebhart, GF | 1 |
| Shrestha, M | 1 |
| Chiu, MJ | 1 |
| Martin, RL | 1 |
| Cush, JJ | 1 |
| Wainscott, MS | 1 |
| Thrush, DN | 1 |
| Steighner, ML | 1 |
| Wright, JM | 1 |
| Price, SD | 1 |
| Watson, WA | 1 |
| Richardson, P | 1 |
| Steingart, R | 1 |
| Uphouse, LA | 1 |
| Welch, SP | 1 |
| Ward, CR | 1 |
| Ellis, EF | 1 |
| Embrey, JP | 1 |
| Blackwell, N | 2 |
| Bangham, L | 2 |
| Hughes, M | 2 |
| Melzack, D | 2 |
| Trotman, I | 2 |
| Silverman, DG | 1 |
| O'Connor, TZ | 1 |
| Brull, SJ | 1 |
| Granados-Soto, V | 1 |
| Flores-Murrieta, FJ | 1 |
| Castañeda-Hernández, G | 1 |
| Hong, E | 1 |
| López-Muñoz, FJ | 2 |
| Miller, LJ | 1 |
| Kramer, MA | 1 |
| Code, W | 1 |
| Hubbell, K | 1 |
| Green, CR | 1 |
| Pandit, SK | 1 |
| Levy, L | 1 |
| Kothary, SP | 1 |
| Tait, AR | 1 |
| Schork, MA | 1 |
| Nitschke, LF | 1 |
| Schlösser, CT | 1 |
| Berg, RL | 1 |
| Selthafner, JV | 1 |
| Wengert, TJ | 1 |
| Avecilla, CS | 1 |
| Puntillo, KA | 1 |
| Parris, WC | 1 |
| Janicki, PK | 1 |
| Johnson, B | 1 |
| Horn, JL | 1 |
| Smith, AJ | 1 |
| Power, I | 1 |
| Gillis, JC | 1 |
| Dexter, TJ | 1 |
| Singh, H | 1 |
| Bossard, RF | 1 |
| White, PF | 1 |
| Yeatts, RW | 1 |
| Yalçin, S | 1 |
| Güllü, I | 1 |
| Tekuzman, G | 1 |
| Savaş, C | 1 |
| Kaiser, PK | 1 |
| Pineda, R | 1 |
| Todd, KH | 1 |
| Ventura, R | 1 |
| Díaz, I | 1 |
| Fernández-Guasti, A | 1 |
| Tost, D | 1 |
| Cabré, F | 1 |
| Mauleón, D | 1 |
| Hall, SR | 1 |
| Milne, B | 1 |
| Loomis, C | 1 |
| McArdle, P | 1 |
| Lilley, LL | 1 |
| Guanci, R | 1 |
| Hardwick, WE | 1 |
| Givens, TG | 1 |
| Monroe, KW | 1 |
| King, WD | 1 |
| Lawley, D | 1 |
| Rogers, A | 1 |
| Kaiko, RF | 1 |
| Heidrich, G | 1 |
| Stacher, G | 1 |
| Bauer, P | 1 |
| Ehn, I | 1 |
| Schreiber, E | 1 |
| Sanders, DY | 1 |
| Severance, HW | 1 |
| Pollack, CV | 1 |
| Wright, SW | 1 |
| Norris, RL | 1 |
| Mitchell, TR | 1 |
| Yealy, DM | 1 |
| Weeks, DB | 1 |
| Goodman, E | 1 |
| Vanos, DN | 1 |
| Ramamurthy, S | 1 |
| Hoffman, J | 1 |
| Freie, HM | 1 |
| Rubin, P | 1 |
| Yee, JP | 1 |
| Ruoff, G | 1 |
| Diebschlag, W | 1 |
| Nocker, W | 1 |
| Bullingham, R | 1 |
| Baumann, TJ | 1 |
| Conrad, KA | 1 |
| Fagan, TC | 1 |
| Mackie, MJ | 1 |
| Mayshar, PV | 1 |
| Halpern, LM | 1 |
| Dong, WK | 1 |
| Amadio, P | 1 |
| Cummings, DM | 1 |
Clinical Trials (6)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Double-blinded Trial Comparing the Clinical Efficacy and Pharmacokinetic Parameters of Oral Diclofenac and Intramuscular Diclofenac in Patients With Acute Limb Injuries[NCT03472339] | Phase 4 | 300 participants (Anticipated) | Interventional | 2018-01-15 | Recruiting | ||
| Exploratory Study on the Use of Pregabalin for the Treatment of Taxol Related Arthralgia-Myalgia[NCT02024568] | Phase 2 | 38 participants (Anticipated) | Interventional | 2013-12-31 | Not yet recruiting | ||
| Preliminary Studies for Whole Genome Association Study (WGAS) in Acute Perioperative Pain[NCT01557751] | 156 participants (Actual) | Interventional | 2010-02-28 | Completed | |||
| A Prospective Randomized Double-blind Placebo Controlled Trial; Does Pre and Postoperative Dextromethorphan Reduce Post-tonsillectomy Pain in Children?[NCT02727491] | Phase 4 | 85 participants (Actual) | Interventional | 2012-03-31 | Completed | ||
| A Randomized Controlled Trial of IV Ketorolac to Prevent Post-ERCP Pancreatitis[NCT02465138] | Phase 4 | 0 participants (Actual) | Interventional | 2023-11-30 | Withdrawn (stopped due to Lack of Funding) | ||
| A Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of Nitric Oxide for Inhalation in the Acute Treatment of Sickle Cell Pain Crisis[NCT00094887] | Phase 2 | 150 participants (Actual) | Interventional | 2004-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
NRS-Pain With Movement on POD 2
"The primary endpoint is the pain reported by subjects, using the NRS-Pain with movement on the second day after surgery.The assumption behind this study is that certain genetic variants (e.g. single-nucleotide polymorphism (SNP) are responsible for part of total variation of certain clinical phenotypes (e.g. post-operative pain here).~Numeric Rating Score Pain Assessment (0-10 scale where 0 indicates no pain at all and 10 indicates the worst pain imaginable) on Post Op Day 2, Pain with Movement" (NCT01557751)
Timeframe: Postoperative day (POD) 2
| Intervention | units on a scale (Mean) |
|---|---|
| Total Knee Arthroplasty Subjects Who Are Genotyped | 2.83 |
Length of Hospitalization
Length of hospitalization is defined as the length of time from admission to discharge order (NCT00094887)
Timeframe: within 40 days
| Intervention | Days (Median) |
|---|---|
| Inhaled Nitric Oxide | 4.06 |
| Placebo | 3.11 |
Number of Participants Discharged to Home Within the First 24 Hours
(NCT00094887)
Timeframe: within 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Inhaled Nitric Oxide | 5 |
| Placebo | 7 |
Number of Participants With Acute Chest Syndrome/Pneumonia Requiring Blood Transfusion
Number of participants who required a blood transfusion before discharge because of acute chest syndrome/pneumonia (NCT00094887)
Timeframe: within 40 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Inhaled Nitric Oxide | 8 |
| Placebo | 7 |
Time to Vaso-occlusive Pain Crisis (VOC) Resolution
"VOC resolution was defined by all of the following conditions:~Pain relief - Visual Analog Scale (VAS) pain scores of 6 or less, (6 as worst and 0 as best)~Freedom from parenteral narcotic use,~Ability to walk unless the subject was not able to walk for any reason other than acute VOC prior to the onset of crisis,~Subject and/or family's belief that the painful crisis could be managed at home with or without oral analgesic use, and the physician concurred with that assessment." (NCT00094887)
Timeframe: within 30 days
| Intervention | Hours (Median) |
|---|---|
| Inhaled Nitric Oxide | 61.83 |
| Placebo | 55.16 |
Number of Participants Readmitted to Hospital Within 30 Days After Discharge
The number of participants readmitted to the hospital for any reason within 30 days after discharge (NCT00094887)
Timeframe: during first 24 hours and during 30 day follow-up
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| during first 24 hours | during 30-day follow-up | |
| Inhaled Nitric Oxide | 0 | 9 |
| Placebo | 0 | 17 |
Total Dose of Opioids Received
The total dose (mg) of opioid medications received during the trial (NCT00094887)
Timeframe: within 8 hours and within 40 days
| Intervention | mg (Median) | |
|---|---|---|
| within 8 hours | within 40 days | |
| Inhaled Nitric Oxide | 16.25 | 153.75 |
| Placebo | 17.25 | 211.37 |
Reviews
4 reviews available for tolmetin and Pain
| Article | Year |
|---|---|
New peripherally-acting oral analgesic agents.
Topics: Administration, Oral; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials | 1983 |
Zomepirac: a review of its pharmacological properties and analgesic efficacy.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Humans; Kinetics; P | 1982 |
Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management.
Topics: Analgesics, Non-Narcotic; Humans; Ketorolac; Pain; Tolmetin | 1997 |
Intravenous analgesia.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Dissociative; Critical Care; Humans; Inje | 1999 |
Trials
35 trials available for tolmetin and Pain
| Article | Year |
|---|---|
A multi-centre study of zomepirac in painful conditions: an analysis of clinical data for 15,484 patients.
Topics: Adolescent; Adult; Aged; Back Pain; Clinical Trials as Topic; Dose-Response Relationship, Drug; Fema | 1983 |
New peripherally-acting oral analgesic agents.
Topics: Administration, Oral; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials | 1983 |
Measurement of pain and analgesia in cancer patients.
Topics: Analgesia; Analgesics; Clinical Trials as Topic; Emotions; Heroin; Humans; Methods; Morphine; Neopla | 1984 |
Double-blind comparisons of zomepirac and oxycodone with APC in cancer pain.
Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug C | 1980 |
Clinical evaluation of zomepirac in the treatment of acute orthopedic pain.
Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug C | 1980 |
Tolmetin sodium and indomethacin in the treatment of osteoarthrosis of the hip: a double-blind crossover study.
Topics: Activities of Daily Living; Aged; Clinical Trials as Topic; Double-Blind Method; Hip; Humans; Indome | 1980 |
Zomepirac sodium -- a new oral analgesic.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Codeine; Dose-Response Relationsh | 1981 |
A double-blind comparative evaluation of tolmetin versus naproxen in osteoarthritis.
Topics: Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Naproxen; Osteoarthritis; Pain; | 1981 |
[An analgesic opens new therapeutic possibilities].
Topics: Analgesics; Clinical Trials as Topic; Double-Blind Method; Humans; Pain; Pyrroles; Tolmetin | 1982 |
The intra-uterine contraceptive device -- an attempt to prevent pain and expulsion with zomepirac sodium.
Topics: Adolescent; Adult; Analgesics; Double-Blind Method; Female; Follow-Up Studies; Humans; Intrauterine | 1982 |
[Comparison of the therapeutic efficacy and tolerability of acemetacin and tolmetin (author's transl)].
Topics: Adult; Aged; Anti-Inflammatory Agents; Double-Blind Method; Female; Humans; In Vitro Techniques; Ind | 1980 |
Intravenous regional anesthesia using lidocaine and ketorolac.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthesia, Conduction; Anesthesia, Intravenous; Anti-Infla | 1995 |
Intramuscular ketorolac versus oral ibuprofen in acute musculoskeletal pain.
Topics: Administration, Oral; Adolescent; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; | 1995 |
Reduction of pain and nausea after laparoscopic sterilization with bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning.
Topics: Analgesics, Non-Narcotic; Bupivacaine; Combined Modality Therapy; Female; Humans; Ketorolac; Laparos | 1995 |
Controlled evaluation of a bandage contact lens and a topical nonsteroidal anti-inflammatory drug in treating traumatic corneal abrasions.
Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Bandages; | 1995 |
Prilocaine reduces injection pain caused by propofol.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anesthesia, Intravenous; Anti-Inflammatory Agents, Non-Steroi | 1995 |
Clinical experience with ketorolac in children.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Drug Administra | 1994 |
Use of ketorolac in the prevention of suxamethonium myalgia.
Topics: Adolescent; Adult; Analgesics; Atracurium; Female; Follow-Up Studies; Humans; Ketorolac; Male; Middl | 1994 |
Use of ketorolac by continuous subcutaneous infusion for the control of cancer-related pain.
Topics: Adult; Aged; Drug Administration Schedule; Female; Humans; Infusion Pumps; Ketorolac Tromethamine; M | 1994 |
Ketorolac as a premedicant for coronary artery bypass surgery patients with normal ventricles.
Topics: Aged; Analgesics; Blood Gas Analysis; Coronary Artery Bypass; Drug Therapy, Combination; Humans; Ket | 1993 |
Subcutaneous ketorolac--a new development in pain control.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; Female; | 1993 |
Intraoperative ketorolac has an opioid-sparing effect in women after diagnostic laparoscopy but not after laparoscopic tubal ligation.
Topics: Adult; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ketorolac Tromethamine; Laparo | 1996 |
Does patient-controlled analgesia achieve better control of pain and fewer adverse effects than intramuscular analgesia? A prospective randomized trial.
Topics: Analgesia, Patient-Controlled; Analgesics; Colon; Confusion; Female; Humans; Injections, Intramuscul | 1996 |
Effects of interpleural bupivacaine on pleural chest tube removal pain: a randomized controlled trial.
Topics: Aged; Analgesics, Opioid; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Bupivacaine; | 1996 |
The effect of pretreatment with ketorolac on pain during intravenous injection of propofol.
Topics: Adult; Ambulatory Surgical Procedures; Analgesics; Anesthetics, Intravenous; Double-Blind Method; Fe | 1996 |
Effects of ketorolac versus bupivacaine coadministration during patient-controlled hydromorphone epidural analgesia after thoracotomy procedures.
Topics: Aged; Analgesia, Epidural; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Bupiva | 1997 |
A study of topical nonsteroidal anti-inflammatory drops and no pressure patching in the treatment of corneal abrasions. Corneal Abrasion Patching Study Group.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Corneal Injuries; Double-Blind Method; Female; Follo | 1997 |
Effect of ketorolac in pediatric sickle cell vaso-occlusive pain crisis.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Anemia, Sickle Cell; Blood Vessels; Child; Double-Blind | 1999 |
Effects of tolmetin, paracetamol, and of two combinations of tolmetin and paracetamol as compared to placebo on experimentally induced pain. A double blind study.
Topics: Acetaminophen; Adult; Clinical Trials as Topic; Drug Therapy, Combination; Electric Stimulation; Fem | 1979 |
Ketorolac for sickle cell vaso-occlusive crisis pain in the emergency department: lack of a narcotic-sparing effect.
Topics: Acute Disease; Adult; Analgesics; Anemia, Sickle Cell; Double-Blind Method; Emergencies; Female; Hum | 1992 |
Comparison of long-term safety of ketorolac tromethamine and aspirin in the treatment of chronic pain.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; D | 1990 |
A double-blind study of the efficacy of topical ketorolac tromethamine gel in the treatment of ankle sprain, in comparison to placebo and etofenamate.
Topics: Acetaminophen; Administration, Topical; Adult; Ankle; Ankle Injuries; Anti-Inflammatory Agents, Non- | 1990 |
Ketorolac tromethamine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Drug Combinations; Humans; Inject | 1990 |
Effects of ketorolac tromethamine on hemostasis in volunteers.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Combinations; Ecchymosis; Hemostasis; | 1988 |
The effect of tolmetin on the chronic pain and decreased functional capacity associated with degenerative joint disease.
Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; M | 1985 |
Other Studies
55 other studies available for tolmetin and Pain
| Article | Year |
|---|---|
Zomepirac-induced renal failure.
Topics: Acute Kidney Injury; Adult; Aged; Arthritis; Back Pain; Body Weight; Coronary Artery Bypass; Creatin | 1983 |
Central effects of zomepirac on pain evoked by intraneural stimulation in man.
Topics: Adolescent; Adult; Double-Blind Method; Electric Stimulation; Humans; Neurons; Pain; Pyrroles; Tolme | 1984 |
Site of analgesic action of zomepirac sodium, a potent non-narcotic analgesic in experimental animals.
Topics: Alprostadil; Analgesics; Animals; Ascitic Fluid; Bradykinin; Dogs; Hypertension; Injections, Intrave | 1983 |
A zomepirac reaction mimicking ectopic pregnancy.
Topics: Adult; Diagnosis, Differential; Drug Hypersensitivity; Female; Humans; Hypotension; Pain; Pregnancy; | 1984 |
Nonoliguric renal failure associated with zomepirac.
Topics: Acute Kidney Injury; Analgesics; Humans; Male; Middle Aged; Oliguria; Pain; Pyrroles; Tolmetin | 1983 |
Zomepirac-induced serum sickness. A report of two cases.
Topics: Adult; Analgesics; Drug Hypersensitivity; Humans; Male; Middle Aged; Pain; Pyrroles; Serum Sickness; | 1983 |
Renal failure and tubular dysfunction due to zomepirac therapy.
Topics: Acidosis, Renal Tubular; Aged; Analgesics; Female; Humans; Joint Diseases; Kidney Failure, Chronic; | 1983 |
The "simple" analgesics.
Topics: Analgesics; Humans; Narcotics; Pain; Salicylates; Tolmetin | 1981 |
Zomepirac sodium. Learn about this potent new non-narcotic analgesic.
Topics: Adult; Analgesics; Child; Female; Humans; Male; Pain; Pyrroles; Tolmetin | 1981 |
Methods for measuring clinical pain in humans.
Topics: Analgesics; Humans; Morphine; Pain; Sensory Thresholds; Tolmetin | 1982 |
[Zomax--progress in analgesia. A new, non-narcotic analgesic].
Topics: Analgesics; Humans; Kinetics; Pain; Pyrroles; Tolmetin | 1981 |
[Preliminary pharmacological studies of a new anti-inflammatory agent: 4'-acetamidophenyl-2-(5'-p-toluyl-1'-methylpyrrole)acetate].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Evaluation, Preclinical; Edema; Male; Pain; P | 1982 |
The analgesic and anti-inflammatory profile of (+/-)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2a]pyrrole-1-carboxylic acid (RS-37619).
Topics: Adrenal Cortex Hormones; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, No | 1982 |
Nonsteroidal anti-inflammatory: zomepirac sodium.
Topics: Aged; Anti-Inflammatory Agents; Humans; Pain; Pyrroles; Tolmetin | 1982 |
Anaphylactic shock, acute renal failure, and disseminated intravascular coagulation. Suspected complications of zomepirac.
Topics: Acute Kidney Injury; Aged; Anaphylaxis; Disseminated Intravascular Coagulation; Humans; Male; Pain; | 1982 |
[A drug fights pain on two levels].
Topics: Analgesics; Humans; Nociceptors; Pain; Pyrroles; Tolmetin | 1982 |
Site of analgesic action of a non-steroidal, anti-inflammatory drug, tolmetin sodium, in rats.
Topics: Administration, Oral; Animals; Ascitic Fluid; Injections, Intraperitoneal; Injections, Intravenous; | 1981 |
Tolmetin-induced aseptic meningitis.
Topics: Adult; Female; Fever; Humans; Ibuprofen; Knee; Lupus Erythematosus, Systemic; Meningitis; Meningitis | 1981 |
Effects of morphine and ketorolac on thermal allodynia induced by prostaglandin E2 and bradykinin in rhesus monkeys.
Topics: Analgesics, Non-Narcotic; Animals; Azocines; Bradykinin; Dinoprostone; Female; Ketorolac; Macaca mul | 1995 |
The use of ketorolac in lumbar spine surgery: a cost-benefit analysis.
Topics: Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Cost-Benefit Analysis; Drug Costs; Female; Hosp | 1995 |
Comparison of ketorolac tromethamine with other injectable nonsteroidal anti-inflammatory drugs for pain-on-injection and muscle damage in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Creatine Kinase; Drug Combinations; Edema; Hemorrh | 1994 |
Ketorolac potentiates morphine antinociception during visceral nociception in the rat.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colon; Dose-Response Relationship, Dru | 1994 |
Treatment of acute gouty arthritis with intramuscular ketorolac tromethamine.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Drug Evaluation; Emergency | 1994 |
NSAID use and efficacy in the emergency department: single doses of oral ibuprofen versus intramuscular ketorolac.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-St | 1994 |
Meperidine and ketorolac in the treatment of painful sickle cell crisis.
Topics: Analgesics; Anemia, Sickle Cell; Humans; Ketorolac; Meperidine; Pain; Tolmetin | 1993 |
Antinociceptive activity of intrathecal ketorolac is blocked by the kappa-opioid receptor antagonist, nor-binaltorphimine.
Topics: Analgesics; Animals; Drug Interactions; Drug Tolerance; Injections, Spinal; Ketorolac; Male; Mice; M | 1993 |
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin | 1993 |
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin | 1993 |
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin | 1993 |
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin | 1993 |
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin | 1993 |
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin | 1993 |
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin | 1993 |
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin | 1993 |
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin | 1993 |
Comparison of the analgesic effects of ketorolac, morphine and aspirin in the rat.
Topics: Analgesics; Animals; Aspirin; Dose-Response Relationship, Drug; Female; Ketorolac; Morphine; Pain; P | 1993 |
Pain management with intravenous ketorolac.
Topics: Adenocarcinoma; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Bile Duct Neoplasms; Chr | 1993 |
Treatment of resistant pain in hypertrophic pulmonary arthropathy with ketorolac.
Topics: Administration, Cutaneous; Aged; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Squamous Cell; | 1993 |
NSAIDs and balanced analgesia.
Topics: Analgesia; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Child; Female; Humans; Infant; Ketor | 1993 |
Problems and pitfalls in providing acute and short-term pain relief with nonsteroidal anti-inflammatory agents.
Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity; Drug Int | 1996 |
Intrathecal ketorolac tromethamine produces analgesia after chronic constriction injury of sciatic nerve in rat.
Topics: Analgesics; Animals; Injections, Spinal; Ketorolac Tromethamine; Male; Morphine; Pain; Rats; Rats, S | 1996 |
The effect of pretreatment with ketorolac on pain during intravenous injection of propofol.
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ketorolac; Pain; Propofol | 1997 |
Ketorolac tromethamine in cancer pain.
Topics: Administration, Oral; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Dr | 1997 |
If you have no destination, any road will do.
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ibuprofen; Ketorolac; Mus | 1998 |
Drugs for pain.
Topics: Acetaminophen; Administration, Oral; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics | 1998 |
Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Biotransformation; Dise | 1998 |
Spinal action of ketorolac, S(+)- and R(-)-ibuprofen on non-noxious activation of the catechol oxidation in the rat locus coeruleus: evidence for a central role of prostaglandins in the strychnine model of allodynia.
Topics: Anesthesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Catechols; Electrophys | 1999 |
Cross sensitivities. Medication errors waiting to happen.
Topics: Analgesics, Non-Narcotic; Aspirin; Asthma; Cross Reactions; Drug Hypersensitivity; Drug Interactions | 1999 |
Clinical analgesic assay of oral zomepirac and intramuscular morphine.
Topics: Administration, Oral; Affect; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Humans; Morp | 1979 |
Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department.
Topics: Acetaminophen; Adolescent; Adult; Amitriptyline; Analgesics; Anemia, Sickle Cell; Anti-Inflammatory | 1992 |
[Pain therapy with Toratex. Official satellite symposium of the Xth World Congress of Anesthesiology. The Haague, 15 June 1992].
Topics: Analgesics; Humans; Ketorolac; Pain; Tolmetin | 1992 |
[Pain therapy with Toratex. Official satellite symposium of the Xth World Congress of Anesthesiology. The Haague, 15 June 1992].
Topics: Analgesics; Humans; Ketorolac; Pain; Tolmetin | 1992 |
[Pain therapy with Toratex. Official satellite symposium of the Xth World Congress of Anesthesiology. The Haague, 15 June 1992].
Topics: Analgesics; Humans; Ketorolac; Pain; Tolmetin | 1992 |
Ketorolac in the treatment of acute pain: the pendulum swings.
Topics: Acute Disease; Analgesics; Humans; Ketorolac; Pain; Tolmetin | 1992 |
Relief of pain by ketorolac or alcohol?
Topics: Analgesics; Autonomic Nerve Block; Autonomic Nervous System Diseases; Ethanol; Humans; Injections, I | 1992 |
[Introductory Press Conference: Toratex--the new mono-analgesics in acute, intense pain. Frankfurt, 21 February 1992].
Topics: Acute Disease; Analgesics; Humans; Ketorolac; Pain; Tolmetin | 1992 |
Use of ketorolac in sickle-cell disease and vaso-occlusive crisis.
Topics: Adult; Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ketorolac; Pain | 1991 |
[Associated symposium: Ketorolac in drug therapy for pain relief. Berlin, October 25, 1991].
Topics: Analgesics; Humans; Ketorolac; Pain; Tolmetin | 1991 |
Intravenous regional block using ketorolac: preliminary results in the treatment of reflex sympathetic dystrophy.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Injections, Intravenous; Ketorolac; | 1992 |
[Treatment of moderate and severe pain. Ketorolac--a new analgesic].
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Humans; Ketorolac; P | 1991 |
The pharmacologic activity of ketorolac tromethamine.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autonomic Nervous System; Ca | 1990 |
Place of ketorolac in pain management.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Ketorolac; Pain; Tolmetin | 1990 |
D-phenylalanine: a putative enkephalinase inhibitor studied in a primate acute pain model.
Topics: Animals; Aspirin; Avoidance Learning; Carboxypeptidases; Drug Interactions; Isomerism; Macaca fascic | 1986 |