Page last updated: 2024-11-05

tolmetin and Pain

tolmetin has been researched along with Pain in 93 studies

Tolmetin: A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.
tolmetin : A monocarboxylic acid that is (1-methylpyrrol-2-yl)acetic acid substituted at position 5 on the pyrrole ring by a 4-methylbenzoyl group. Used in the form of its sodium salt dihydrate as a nonselective nonsteroidal anti-inflammatory drug.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"Patients receiving ketorolac and those receiving placebo were of similar age, weight, gender, number of prior ED visits, number of prior hospital admissions, duration of pain prior to presentation, and initial pain score."9.09Effect of ketorolac in pediatric sickle cell vaso-occlusive pain crisis. ( Givens, TG; Hardwick, WE; King, WD; Lawley, D; Monroe, KW, 1999)
"A randomised, double-blind, controlled trial was undertaken to compare three different methods of reducing pain during the intravenous injection of propofol."9.08The effect of pretreatment with ketorolac on pain during intravenous injection of propofol. ( Power, I; Smith, AJ, 1996)
"IM ketorolac and oral ibuprofen provide comparable analgesia in ED patients with acute musculoskeletal pain."9.08Intramuscular ketorolac versus oral ibuprofen in acute musculoskeletal pain. ( Paris, PM; Seaberg, DC; Turturro, MA, 1995)
"To determine whether postoperative pain and nausea after laparoscopic sterilization can be reduced with a combination of bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning."9.08Reduction of pain and nausea after laparoscopic sterilization with bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning. ( Bradford, TH; Meeks, GR; Norman, PF; Robertson, K, 1995)
"Propofol, which is commonly used for outpatient anaesthesia, may evoke pain during infusion."9.08Prilocaine reduces injection pain caused by propofol. ( Eriksson, M, 1995)
"25% bupivacaine without epinephrine to those of normal saline on chest tube removal pain in cardiothoracic surgery patients."9.08Effects of interpleural bupivacaine on pleural chest tube removal pain: a randomized controlled trial. ( Puntillo, KA, 1996)
" Subjects were administered meperidine on presentation and then received a standardized dose of meperidine every 30 minutes during the four-hour observation period based on the severity of pain."9.07Ketorolac for sickle cell vaso-occlusive crisis pain in the emergency department: lack of a narcotic-sparing effect. ( Mitchell, TR; Norris, RL; Wright, SW, 1992)
"An open, multi-centre study was carried out in patients with various moderate to severe painful conditions to assess the effectiveness of zomepirac in relieving pain."9.05A multi-centre study of zomepirac in painful conditions: an analysis of clinical data for 15,484 patients. ( Jefferson, WL; Steele, CE, 1983)
"We investigated the antinociceptive properties of dexketoprofen trometamol [S(+)-ketoprofen tromethamine salt; SKP], a new analgesic, antiinflammatory drug, using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain."7.70Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid. ( Cabré, F; Díaz, I; Fernández-Guasti, A; López-Muñoz, FJ; Mauleón, D; Tost, D; Ventura, R, 1998)
"To report a case in which intravenous ketorolac was used successfully on a chronic basis to treat cancer pain."7.68Pain management with intravenous ketorolac. ( Kramer, MA; Miller, LJ, 1993)
" Patients were allocated at random to treatment with either 800 mg tolmetin sodium daily or 500 mg naproxen daily over a period of 12 weeks, both drugs being given in identical capsule form in a dosage of 2 capsules twice daily."6.65A double-blind comparative evaluation of tolmetin versus naproxen in osteoarthritis. ( Bach-Andersen, R; Persson, B; Telhag, H, 1981)
" The incidence of serious or fatal adverse events reported with ketorolac has decreased since revision of dosage guidelines."6.40Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management. ( Brogden, RN; Gillis, JC, 1997)
"Pain was quantified in 6 of the patients using a 10-cm visual analog scale that the patients completed before and 30, 60, and 90 minutes after ketorolac administration."5.29Treatment of acute gouty arthritis with intramuscular ketorolac tromethamine. ( Chiu, MJ; Cush, JJ; Martin, RL; Shrestha, M; Wainscott, MS, 1994)
"A 21-year-old woman with systemic lupus erythematosus (SLE) had meningismus, conjunctivitis, lymphadenopathy, and elevation of liver function values following ibuprofen therapy."5.26Tolmetin-induced aseptic meningitis. ( Barth, WF; Ruppert, GB, 1981)
"Patients receiving ketorolac and those receiving placebo were of similar age, weight, gender, number of prior ED visits, number of prior hospital admissions, duration of pain prior to presentation, and initial pain score."5.09Effect of ketorolac in pediatric sickle cell vaso-occlusive pain crisis. ( Givens, TG; Hardwick, WE; King, WD; Lawley, D; Monroe, KW, 1999)
"Propofol, which is commonly used for outpatient anaesthesia, may evoke pain during infusion."5.08Prilocaine reduces injection pain caused by propofol. ( Eriksson, M, 1995)
"We studied the comparative effects of ketorolac versus bupivacaine supplementation of hydromorphone (HM) patient-controlled epidural analgesia (PCEA) on the HM requirement, postoperative pain, and pulmonary function in 62 consenting patients after thoracotomy procedures."5.08Effects of ketorolac versus bupivacaine coadministration during patient-controlled hydromorphone epidural analgesia after thoracotomy procedures. ( Bossard, RF; Singh, H; White, PF; Yeatts, RW, 1997)
"IM ketorolac and oral ibuprofen provide comparable analgesia in ED patients with acute musculoskeletal pain."5.08Intramuscular ketorolac versus oral ibuprofen in acute musculoskeletal pain. ( Paris, PM; Seaberg, DC; Turturro, MA, 1995)
"To determine whether postoperative pain and nausea after laparoscopic sterilization can be reduced with a combination of bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning."5.08Reduction of pain and nausea after laparoscopic sterilization with bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning. ( Bradford, TH; Meeks, GR; Norman, PF; Robertson, K, 1995)
"A randomised, double-blind, controlled trial was undertaken to compare three different methods of reducing pain during the intravenous injection of propofol."5.08The effect of pretreatment with ketorolac on pain during intravenous injection of propofol. ( Power, I; Smith, AJ, 1996)
"25% bupivacaine without epinephrine to those of normal saline on chest tube removal pain in cardiothoracic surgery patients."5.08Effects of interpleural bupivacaine on pleural chest tube removal pain: a randomized controlled trial. ( Puntillo, KA, 1996)
"While it appears that ketorolac provides a better postoperative course than either IM or PCA morphine in terms of pain control, postoperative confusion, length of stay, and duration of ileus, 18% of our patients assigned to ketorolac required additional analgesia, and there was a strong patient preference for PCA."5.08Does patient-controlled analgesia achieve better control of pain and fewer adverse effects than intramuscular analgesia? A prospective randomized trial. ( Avecilla, CS; Berg, RL; Nitschke, LF; Schlösser, CT; Selthafner, JV; Wengert, TJ, 1996)
" Subjects were administered meperidine on presentation and then received a standardized dose of meperidine every 30 minutes during the four-hour observation period based on the severity of pain."5.07Ketorolac for sickle cell vaso-occlusive crisis pain in the emergency department: lack of a narcotic-sparing effect. ( Mitchell, TR; Norris, RL; Wright, SW, 1992)
"In a double-blind, placebo-controlled study the efficacy and safety of topical ketorolac tromethamine were assessed in the reduction of inflammation and pain due to ankle sprain."5.06A double-blind study of the efficacy of topical ketorolac tromethamine gel in the treatment of ankle sprain, in comparison to placebo and etofenamate. ( Bullingham, R; Diebschlag, W; Nocker, W, 1990)
"In a controlled double blind study the therapeutic efficacy and tolerability of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-acetoxy] acetic acid (acemetacin, TV 1322, Rantudil¿) and tolmetin were compared in 40 patients suffering from acute and subacute painful irritant conditions in the spinal area and joints."5.05[Comparison of the therapeutic efficacy and tolerability of acemetacin and tolmetin (author's transl)]. ( Handrich, L, 1980)
" For occasional moderate pain not responsive to aspirin, zomepirac may prove to be preferable to oral narcotics such as codeine, oxycodone, propoxyphene, pentazocine and meperidine."5.05Zomepirac sodium -- a new oral analgesic. ( , 1981)
"An open, multi-centre study was carried out in patients with various moderate to severe painful conditions to assess the effectiveness of zomepirac in relieving pain."5.05A multi-centre study of zomepirac in painful conditions: an analysis of clinical data for 15,484 patients. ( Jefferson, WL; Steele, CE, 1983)
"We investigated the antinociceptive properties of dexketoprofen trometamol [S(+)-ketoprofen tromethamine salt; SKP], a new analgesic, antiinflammatory drug, using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain."3.70Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid. ( Cabré, F; Díaz, I; Fernández-Guasti, A; López-Muñoz, FJ; Mauleón, D; Tost, D; Ventura, R, 1998)
"To compare the clinical efficacy of single doses of intramuscular ketorolac and oral ibuprofen in the emergency department (ED) treatment of acute pain."3.69NSAID use and efficacy in the emergency department: single doses of oral ibuprofen versus intramuscular ketorolac. ( Price, SD; Watson, WA; Wright, JM, 1994)
"The study compared analgesic efficacy of intrathecally administered ketorolac tromethamine (K) and morphine hydrochloride (M) (in equimolar doses) in the chronic neuropathic pain model, induced by chronic constriction injury (CCI) of the sciatic nerve in rat."3.69Intrathecal ketorolac tromethamine produces analgesia after chronic constriction injury of sciatic nerve in rat. ( Horn, JL; Janicki, PK; Johnson, B; Parris, WC, 1996)
"To report a case in which intravenous ketorolac was used successfully on a chronic basis to treat cancer pain."3.68Pain management with intravenous ketorolac. ( Kramer, MA; Miller, LJ, 1993)
"Zomepirac sodium is a new nonsteroidal anti-inflammatory agent for management of mild to moderate pain."3.66Zomepirac-induced renal failure. ( Lacher, JW; Miller, FC; Schorr, WJ, 1983)
"Zomepirac sodium inhibited the reflex hypertension caused by an injection of bradykinin into the splenic artery of anaesthetized dogs, but not that by injection of bradykinin plus PGE1."3.66Site of analgesic action of zomepirac sodium, a potent non-narcotic analgesic in experimental animals. ( Imazu, C; Ishii, K; Kadokawa, T; Nakamura, H; Shimizu, M; Yokoyama, Y, 1983)
"Ketorolac tromethamine (Toradol) is a parenteral, nonsteroidal antiinflammatory drug that is being extensively used to provide postoperative analgesia."2.68Intraoperative ketorolac has an opioid-sparing effect in women after diagnostic laparoscopy but not after laparoscopic tubal ligation. ( Green, CR; Kothary, SP; Levy, L; Pandit, SK; Schork, MA; Tait, AR, 1996)
"Treating traumatic corneal abrasions is a common problem for the ophthalmologist."2.68Controlled evaluation of a bandage contact lens and a topical nonsteroidal anti-inflammatory drug in treating traumatic corneal abrasions. ( Cohen, AJ; Donnenfeld, ED; Moadel, K; Perry, HD; Selkin, BA; Selkin, GT; Sperber, LT, 1995)
"Ketorolac tromethamine is a newly available non-steroidal anti-inflammatory drug which is suitable for parenteral administration."2.67Use of ketorolac by continuous subcutaneous infusion for the control of cancer-related pain. ( Myers, KG; Trotman, IF, 1994)
"Ketorolac appears to be a safe and effective therapy for children when given in appropriate doses for a limited duration."2.67Clinical experience with ketorolac in children. ( Buck, ML, 1994)
" Patients were allocated at random to treatment with either 800 mg tolmetin sodium daily or 500 mg naproxen daily over a period of 12 weeks, both drugs being given in identical capsule form in a dosage of 2 capsules twice daily."2.65A double-blind comparative evaluation of tolmetin versus naproxen in osteoarthritis. ( Bach-Andersen, R; Persson, B; Telhag, H, 1981)
"Pain is traditionally measured in analgesic studies by employing verbal descriptors of intensity, but more recently visual analogues of pain intensity have been used and generally provide more sensitive measures of pain intensity."2.65Measurement of pain and analgesia in cancer patients. ( Wallenstein, SL, 1984)
" The incidence of serious or fatal adverse events reported with ketorolac has decreased since revision of dosage guidelines."2.40Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management. ( Brogden, RN; Gillis, JC, 1997)
"Zomepirac is an analgesic which is closely related chemically to the nonsteroidal anti-inflammatory agent, tolmetin."2.36Zomepirac: a review of its pharmacological properties and analgesic efficacy. ( Avery, GS; Brogden, RN; Carmine, AA; Heel, RC; Morley, PA; Speight, TM, 1982)
"Pain was quantified in 6 of the patients using a 10-cm visual analog scale that the patients completed before and 30, 60, and 90 minutes after ketorolac administration."1.29Treatment of acute gouty arthritis with intramuscular ketorolac tromethamine. ( Chiu, MJ; Cush, JJ; Martin, RL; Shrestha, M; Wainscott, MS, 1994)
"The pressor response to noxious colorectal distention (80 mmHg, 20 s) was evaluated in 29 male Sprague-Dawley rats and dose-response curves were determined for intravenous morphine, ketorolac and the mixture of morphine and ketorolac."1.29Ketorolac potentiates morphine antinociception during visceral nociception in the rat. ( Gebhart, GF; Maves, TJ; Meller, ST; Pechman, PS, 1994)
"The gene for sickle cell disease is carried by 8% of the African-American population in the United States."1.28Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department. ( Pollack, CV; Sanders, DY; Severance, HW, 1992)
"Ketorolac tromethamine is a highly potent member of a class of compounds having both analgesic and antiinflammatory activity."1.28The pharmacologic activity of ketorolac tromethamine. ( Rooks, WH, 1990)
"A 21-year-old woman with systemic lupus erythematosus (SLE) had meningismus, conjunctivitis, lymphadenopathy, and elevation of liver function values following ibuprofen therapy."1.26Tolmetin-induced aseptic meningitis. ( Barth, WF; Ruppert, GB, 1981)
"2 Tolmetin sodium was administered to the rat between 15 and 60 min after intraperitoneal injection of 1 ml of a 1% acetic acid aqueous solution."1.26Site of analgesic action of a non-steroidal, anti-inflammatory drug, tolmetin sodium, in rats. ( Nakamura, H; Shimizu, M, 1981)
"Zomepirac appears to be an unexpectedly effective oral, non-opioid analgesic."1.26Clinical analgesic assay of oral zomepirac and intramuscular morphine. ( Heidrich, G; Houde, RW; Kaiko, RF; Rogers, A; Wallenstein, SL, 1979)

Research

Studies (93)

TimeframeStudies, this research(%)All Research%
pre-199035 (37.63)18.7374
1990's58 (62.37)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Steele, CE2
Jefferson, WL1
Miller, FC1
Schorr, WJ1
Lacher, JW1
Cooper, SA1
Wallenstein, SL2
Schady, W1
Torebjörk, HE1
Nakamura, H2
Imazu, C1
Ishii, K1
Yokoyama, Y1
Kadokawa, T1
Shimizu, M2
Creasy, GW1
Kousen, M1
Walker, WR1
Lisker, WH1
Kiani, R1
Kushner, M1
Warren, SE1
Mosley, C1
Mar, DD1
Gever, LN1
Houde, RW2
Braun, H1
Cenarruzabeitia, E1
Lasheras, B1
Fontan, JL1
Rooks, WH2
Tomolonis, AJ1
Maloney, PJ1
Wallach, MB1
Schuler, ME1
Stambaugh, JE1
Tejada, F1
Trudnowski, RJ1
Mayer, TG1
Ruoff, GE1
Davies, J1
Dixon, AS1
Telhag, H1
Bach-Andersen, R1
Persson, B1
Morley, PA1
Brogden, RN2
Carmine, AA1
Heel, RC1
Speight, TM1
Avery, GS1
van Thiel, D2
Gorder, JW1
Smith, VT1
Theron, F1
Handrich, L1
Ruppert, GB1
Barth, WF1
Reuben, SS1
Steinberg, RB1
Kreitzer, JM1
Duprat, KM1
Turturro, MA1
Paris, PM1
Seaberg, DC1
Negus, SS1
Butelman, ER1
Gatch, MB1
Woods, JH1
Turner, DM1
Warson, JS1
Wirt, TC1
Scalley, RD1
Cochran, RS1
Miller, KJ1
Bradford, TH1
Robertson, K1
Norman, PF1
Meeks, GR1
Donnenfeld, ED1
Selkin, BA1
Perry, HD1
Moadel, K1
Selkin, GT1
Cohen, AJ1
Sperber, LT1
Eriksson, M1
Buck, ML1
Leeson-Payne, CG1
Nicoll, JM1
Hobbs, GJ1
Chellman, GJ1
Lollini, LO1
Dorr, AE1
DePass, LR1
Myers, KG1
Trotman, IF1
Maves, TJ1
Pechman, PS1
Meller, ST1
Gebhart, GF1
Shrestha, M1
Chiu, MJ1
Martin, RL1
Cush, JJ1
Wainscott, MS1
Thrush, DN1
Steighner, ML1
Wright, JM1
Price, SD1
Watson, WA1
Richardson, P1
Steingart, R1
Uphouse, LA1
Welch, SP1
Ward, CR1
Ellis, EF1
Embrey, JP1
Blackwell, N2
Bangham, L2
Hughes, M2
Melzack, D2
Trotman, I2
Silverman, DG1
O'Connor, TZ1
Brull, SJ1
Granados-Soto, V1
Flores-Murrieta, FJ1
Castañeda-Hernández, G1
Hong, E1
López-Muñoz, FJ2
Miller, LJ1
Kramer, MA1
Code, W1
Hubbell, K1
Green, CR1
Pandit, SK1
Levy, L1
Kothary, SP1
Tait, AR1
Schork, MA1
Nitschke, LF1
Schlösser, CT1
Berg, RL1
Selthafner, JV1
Wengert, TJ1
Avecilla, CS1
Puntillo, KA1
Parris, WC1
Janicki, PK1
Johnson, B1
Horn, JL1
Smith, AJ1
Power, I1
Gillis, JC1
Dexter, TJ1
Singh, H1
Bossard, RF1
White, PF1
Yeatts, RW1
Yalçin, S1
Güllü, I1
Tekuzman, G1
Savaş, C1
Kaiser, PK1
Pineda, R1
Todd, KH1
Ventura, R1
Díaz, I1
Fernández-Guasti, A1
Tost, D1
Cabré, F1
Mauleón, D1
Hall, SR1
Milne, B1
Loomis, C1
McArdle, P1
Lilley, LL1
Guanci, R1
Hardwick, WE1
Givens, TG1
Monroe, KW1
King, WD1
Lawley, D1
Rogers, A1
Kaiko, RF1
Heidrich, G1
Stacher, G1
Bauer, P1
Ehn, I1
Schreiber, E1
Sanders, DY1
Severance, HW1
Pollack, CV1
Wright, SW1
Norris, RL1
Mitchell, TR1
Yealy, DM1
Weeks, DB1
Goodman, E1
Vanos, DN1
Ramamurthy, S1
Hoffman, J1
Freie, HM1
Rubin, P1
Yee, JP1
Ruoff, G1
Diebschlag, W1
Nocker, W1
Bullingham, R1
Baumann, TJ1
Conrad, KA1
Fagan, TC1
Mackie, MJ1
Mayshar, PV1
Halpern, LM1
Dong, WK1
Amadio, P1
Cummings, DM1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized Double-blinded Trial Comparing the Clinical Efficacy and Pharmacokinetic Parameters of Oral Diclofenac and Intramuscular Diclofenac in Patients With Acute Limb Injuries[NCT03472339]Phase 4300 participants (Anticipated)Interventional2018-01-15Recruiting
Exploratory Study on the Use of Pregabalin for the Treatment of Taxol Related Arthralgia-Myalgia[NCT02024568]Phase 238 participants (Anticipated)Interventional2013-12-31Not yet recruiting
Preliminary Studies for Whole Genome Association Study (WGAS) in Acute Perioperative Pain[NCT01557751]156 participants (Actual)Interventional2010-02-28Completed
A Prospective Randomized Double-blind Placebo Controlled Trial; Does Pre and Postoperative Dextromethorphan Reduce Post-tonsillectomy Pain in Children?[NCT02727491]Phase 485 participants (Actual)Interventional2012-03-31Completed
A Randomized Controlled Trial of IV Ketorolac to Prevent Post-ERCP Pancreatitis[NCT02465138]Phase 40 participants (Actual)Interventional2023-11-30Withdrawn (stopped due to Lack of Funding)
A Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of Nitric Oxide for Inhalation in the Acute Treatment of Sickle Cell Pain Crisis[NCT00094887]Phase 2150 participants (Actual)Interventional2004-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

NRS-Pain With Movement on POD 2

"The primary endpoint is the pain reported by subjects, using the NRS-Pain with movement on the second day after surgery.The assumption behind this study is that certain genetic variants (e.g. single-nucleotide polymorphism (SNP) are responsible for part of total variation of certain clinical phenotypes (e.g. post-operative pain here).~Numeric Rating Score Pain Assessment (0-10 scale where 0 indicates no pain at all and 10 indicates the worst pain imaginable) on Post Op Day 2, Pain with Movement" (NCT01557751)
Timeframe: Postoperative day (POD) 2

Interventionunits on a scale (Mean)
Total Knee Arthroplasty Subjects Who Are Genotyped2.83

Length of Hospitalization

Length of hospitalization is defined as the length of time from admission to discharge order (NCT00094887)
Timeframe: within 40 days

InterventionDays (Median)
Inhaled Nitric Oxide4.06
Placebo3.11

Number of Participants Discharged to Home Within the First 24 Hours

(NCT00094887)
Timeframe: within 24 hours

InterventionParticipants (Count of Participants)
Inhaled Nitric Oxide5
Placebo7

Number of Participants With Acute Chest Syndrome/Pneumonia Requiring Blood Transfusion

Number of participants who required a blood transfusion before discharge because of acute chest syndrome/pneumonia (NCT00094887)
Timeframe: within 40 days

InterventionParticipants (Count of Participants)
Inhaled Nitric Oxide8
Placebo7

Time to Vaso-occlusive Pain Crisis (VOC) Resolution

"VOC resolution was defined by all of the following conditions:~Pain relief - Visual Analog Scale (VAS) pain scores of 6 or less, (6 as worst and 0 as best)~Freedom from parenteral narcotic use,~Ability to walk unless the subject was not able to walk for any reason other than acute VOC prior to the onset of crisis,~Subject and/or family's belief that the painful crisis could be managed at home with or without oral analgesic use, and the physician concurred with that assessment." (NCT00094887)
Timeframe: within 30 days

InterventionHours (Median)
Inhaled Nitric Oxide61.83
Placebo55.16

Number of Participants Readmitted to Hospital Within 30 Days After Discharge

The number of participants readmitted to the hospital for any reason within 30 days after discharge (NCT00094887)
Timeframe: during first 24 hours and during 30 day follow-up

,
InterventionParticipants (Count of Participants)
during first 24 hoursduring 30-day follow-up
Inhaled Nitric Oxide09
Placebo017

Total Dose of Opioids Received

The total dose (mg) of opioid medications received during the trial (NCT00094887)
Timeframe: within 8 hours and within 40 days

,
Interventionmg (Median)
within 8 hourswithin 40 days
Inhaled Nitric Oxide16.25153.75
Placebo17.25211.37

Reviews

4 reviews available for tolmetin and Pain

ArticleYear
New peripherally-acting oral analgesic agents.
    Annual review of pharmacology and toxicology, 1983, Volume: 23

    Topics: Administration, Oral; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials

1983
Zomepirac: a review of its pharmacological properties and analgesic efficacy.
    Drugs, 1982, Volume: 23, Issue:4

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Humans; Kinetics; P

1982
Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management.
    Drugs, 1997, Volume: 53, Issue:1

    Topics: Analgesics, Non-Narcotic; Humans; Ketorolac; Pain; Tolmetin

1997
Intravenous analgesia.
    Critical care clinics, 1999, Volume: 15, Issue:1

    Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Dissociative; Critical Care; Humans; Inje

1999

Trials

35 trials available for tolmetin and Pain

ArticleYear
A multi-centre study of zomepirac in painful conditions: an analysis of clinical data for 15,484 patients.
    Current medical research and opinion, 1983, Volume: 8, Issue:6

    Topics: Adolescent; Adult; Aged; Back Pain; Clinical Trials as Topic; Dose-Response Relationship, Drug; Fema

1983
New peripherally-acting oral analgesic agents.
    Annual review of pharmacology and toxicology, 1983, Volume: 23

    Topics: Administration, Oral; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials

1983
Measurement of pain and analgesia in cancer patients.
    Cancer, 1984, May-15, Volume: 53, Issue:10 Suppl

    Topics: Analgesia; Analgesics; Clinical Trials as Topic; Emotions; Heroin; Humans; Methods; Morphine; Neopla

1984
Double-blind comparisons of zomepirac and oxycodone with APC in cancer pain.
    Journal of clinical pharmacology, 1980, Volume: 20, Issue:4

    Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug C

1980
Clinical evaluation of zomepirac in the treatment of acute orthopedic pain.
    Journal of clinical pharmacology, 1980, Volume: 20, Issue:4

    Topics: Adult; Analgesics; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug C

1980
Tolmetin sodium and indomethacin in the treatment of osteoarthrosis of the hip: a double-blind crossover study.
    Current medical research and opinion, 1980, Volume: 7, Issue:2

    Topics: Activities of Daily Living; Aged; Clinical Trials as Topic; Double-Blind Method; Hip; Humans; Indome

1980
Zomepirac sodium -- a new oral analgesic.
    The Medical letter on drugs and therapeutics, 1981, Jan-09, Volume: 23, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Codeine; Dose-Response Relationsh

1981
A double-blind comparative evaluation of tolmetin versus naproxen in osteoarthritis.
    Current medical research and opinion, 1981, Volume: 7, Issue:6

    Topics: Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Naproxen; Osteoarthritis; Pain;

1981
[An analgesic opens new therapeutic possibilities].
    Therapie der Gegenwart, 1982, Volume: 121, Issue:7

    Topics: Analgesics; Clinical Trials as Topic; Double-Blind Method; Humans; Pain; Pyrroles; Tolmetin

1982
The intra-uterine contraceptive device -- an attempt to prevent pain and expulsion with zomepirac sodium.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1982, Jun-12, Volume: 61, Issue:24

    Topics: Adolescent; Adult; Analgesics; Double-Blind Method; Female; Follow-Up Studies; Humans; Intrauterine

1982
[Comparison of the therapeutic efficacy and tolerability of acemetacin and tolmetin (author's transl)].
    Arzneimittel-Forschung, 1980, Volume: 30, Issue:8A

    Topics: Adult; Aged; Anti-Inflammatory Agents; Double-Blind Method; Female; Humans; In Vitro Techniques; Ind

1980
Intravenous regional anesthesia using lidocaine and ketorolac.
    Anesthesia and analgesia, 1995, Volume: 81, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthesia, Conduction; Anesthesia, Intravenous; Anti-Infla

1995
Intramuscular ketorolac versus oral ibuprofen in acute musculoskeletal pain.
    Annals of emergency medicine, 1995, Volume: 26, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal;

1995
Reduction of pain and nausea after laparoscopic sterilization with bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning.
    Obstetrics and gynecology, 1995, Volume: 85, Issue:5 Pt 1

    Topics: Analgesics, Non-Narcotic; Bupivacaine; Combined Modality Therapy; Female; Humans; Ketorolac; Laparos

1995
Controlled evaluation of a bandage contact lens and a topical nonsteroidal anti-inflammatory drug in treating traumatic corneal abrasions.
    Ophthalmology, 1995, Volume: 102, Issue:6

    Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Bandages;

1995
Prilocaine reduces injection pain caused by propofol.
    Acta anaesthesiologica Scandinavica, 1995, Volume: 39, Issue:2

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anesthesia, Intravenous; Anti-Inflammatory Agents, Non-Steroi

1995
Clinical experience with ketorolac in children.
    The Annals of pharmacotherapy, 1994, Volume: 28, Issue:9

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Drug Administra

1994
Use of ketorolac in the prevention of suxamethonium myalgia.
    British journal of anaesthesia, 1994, Volume: 73, Issue:6

    Topics: Adolescent; Adult; Analgesics; Atracurium; Female; Follow-Up Studies; Humans; Ketorolac; Male; Middl

1994
Use of ketorolac by continuous subcutaneous infusion for the control of cancer-related pain.
    Postgraduate medical journal, 1994, Volume: 70, Issue:823

    Topics: Adult; Aged; Drug Administration Schedule; Female; Humans; Infusion Pumps; Ketorolac Tromethamine; M

1994
Ketorolac as a premedicant for coronary artery bypass surgery patients with normal ventricles.
    Nurse anesthesia, 1993, Volume: 4, Issue:4

    Topics: Aged; Analgesics; Blood Gas Analysis; Coronary Artery Bypass; Drug Therapy, Combination; Humans; Ket

1993
Subcutaneous ketorolac--a new development in pain control.
    Palliative medicine, 1993, Volume: 7, Issue:1

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; Female;

1993
Intraoperative ketorolac has an opioid-sparing effect in women after diagnostic laparoscopy but not after laparoscopic tubal ligation.
    Anesthesia and analgesia, 1996, Volume: 82, Issue:4

    Topics: Adult; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ketorolac Tromethamine; Laparo

1996
Does patient-controlled analgesia achieve better control of pain and fewer adverse effects than intramuscular analgesia? A prospective randomized trial.
    Archives of surgery (Chicago, Ill. : 1960), 1996, Volume: 131, Issue:4

    Topics: Analgesia, Patient-Controlled; Analgesics; Colon; Confusion; Female; Humans; Injections, Intramuscul

1996
Effects of interpleural bupivacaine on pleural chest tube removal pain: a randomized controlled trial.
    American journal of critical care : an official publication, American Association of Critical-Care Nurses, 1996, Volume: 5, Issue:2

    Topics: Aged; Analgesics, Opioid; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Bupivacaine;

1996
The effect of pretreatment with ketorolac on pain during intravenous injection of propofol.
    Anaesthesia, 1996, Volume: 51, Issue:9

    Topics: Adult; Ambulatory Surgical Procedures; Analgesics; Anesthetics, Intravenous; Double-Blind Method; Fe

1996
Effects of ketorolac versus bupivacaine coadministration during patient-controlled hydromorphone epidural analgesia after thoracotomy procedures.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:3

    Topics: Aged; Analgesia, Epidural; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Bupiva

1997
A study of topical nonsteroidal anti-inflammatory drops and no pressure patching in the treatment of corneal abrasions. Corneal Abrasion Patching Study Group.
    Ophthalmology, 1997, Volume: 104, Issue:8

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Corneal Injuries; Double-Blind Method; Female; Follo

1997
Effect of ketorolac in pediatric sickle cell vaso-occlusive pain crisis.
    Pediatric emergency care, 1999, Volume: 15, Issue:3

    Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Anemia, Sickle Cell; Blood Vessels; Child; Double-Blind

1999
Effects of tolmetin, paracetamol, and of two combinations of tolmetin and paracetamol as compared to placebo on experimentally induced pain. A double blind study.
    International journal of clinical pharmacology and biopharmacy, 1979, Volume: 17, Issue:6

    Topics: Acetaminophen; Adult; Clinical Trials as Topic; Drug Therapy, Combination; Electric Stimulation; Fem

1979
Ketorolac for sickle cell vaso-occlusive crisis pain in the emergency department: lack of a narcotic-sparing effect.
    Annals of emergency medicine, 1992, Volume: 21, Issue:8

    Topics: Acute Disease; Adult; Analgesics; Anemia, Sickle Cell; Double-Blind Method; Emergencies; Female; Hum

1992
Comparison of long-term safety of ketorolac tromethamine and aspirin in the treatment of chronic pain.
    Pharmacotherapy, 1990, Volume: 10, Issue:6 ( Pt 2)

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; D

1990
A double-blind study of the efficacy of topical ketorolac tromethamine gel in the treatment of ankle sprain, in comparison to placebo and etofenamate.
    Journal of clinical pharmacology, 1990, Volume: 30, Issue:1

    Topics: Acetaminophen; Administration, Topical; Adult; Ankle; Ankle Injuries; Anti-Inflammatory Agents, Non-

1990
Ketorolac tromethamine.
    The Medical letter on drugs and therapeutics, 1990, Aug-24, Volume: 32, Issue:825

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Drug Combinations; Humans; Inject

1990
Effects of ketorolac tromethamine on hemostasis in volunteers.
    Clinical pharmacology and therapeutics, 1988, Volume: 43, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Combinations; Ecchymosis; Hemostasis;

1988
The effect of tolmetin on the chronic pain and decreased functional capacity associated with degenerative joint disease.
    Journal of clinical pharmacology, 1985, Volume: 25, Issue:2

    Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; M

1985

Other Studies

55 other studies available for tolmetin and Pain

ArticleYear
Zomepirac-induced renal failure.
    Archives of internal medicine, 1983, Volume: 143, Issue:6

    Topics: Acute Kidney Injury; Adult; Aged; Arthritis; Back Pain; Body Weight; Coronary Artery Bypass; Creatin

1983
Central effects of zomepirac on pain evoked by intraneural stimulation in man.
    Journal of clinical pharmacology, 1984, Volume: 24, Issue:10

    Topics: Adolescent; Adult; Double-Blind Method; Electric Stimulation; Humans; Neurons; Pain; Pyrroles; Tolme

1984
Site of analgesic action of zomepirac sodium, a potent non-narcotic analgesic in experimental animals.
    Japanese journal of pharmacology, 1983, Volume: 33, Issue:4

    Topics: Alprostadil; Analgesics; Animals; Ascitic Fluid; Bradykinin; Dogs; Hypertension; Injections, Intrave

1983
A zomepirac reaction mimicking ectopic pregnancy.
    Drug intelligence & clinical pharmacy, 1984, Volume: 18, Issue:6

    Topics: Adult; Diagnosis, Differential; Drug Hypersensitivity; Female; Humans; Hypotension; Pain; Pregnancy;

1984
Nonoliguric renal failure associated with zomepirac.
    JAMA, 1983, Apr-01, Volume: 249, Issue:13

    Topics: Acute Kidney Injury; Analgesics; Humans; Male; Middle Aged; Oliguria; Pain; Pyrroles; Tolmetin

1983
Zomepirac-induced serum sickness. A report of two cases.
    JAMA, 1983, May-27, Volume: 249, Issue:20

    Topics: Adult; Analgesics; Drug Hypersensitivity; Humans; Male; Middle Aged; Pain; Pyrroles; Serum Sickness;

1983
Renal failure and tubular dysfunction due to zomepirac therapy.
    JAMA, 1983, Jan-21, Volume: 249, Issue:3

    Topics: Acidosis, Renal Tubular; Aged; Analgesics; Female; Humans; Joint Diseases; Kidney Failure, Chronic;

1983
The "simple" analgesics.
    The American journal of nursing, 1981, Volume: 81, Issue:6

    Topics: Analgesics; Humans; Narcotics; Pain; Salicylates; Tolmetin

1981
Zomepirac sodium. Learn about this potent new non-narcotic analgesic.
    Nursing, 1981, Volume: 11, Issue:6

    Topics: Adult; Analgesics; Child; Female; Humans; Male; Pain; Pyrroles; Tolmetin

1981
Methods for measuring clinical pain in humans.
    Acta anaesthesiologica Scandinavica. Supplementum, 1982, Volume: 74

    Topics: Analgesics; Humans; Morphine; Pain; Sensory Thresholds; Tolmetin

1982
[Zomax--progress in analgesia. A new, non-narcotic analgesic].
    Swiss dent, 1981, Volume: 2, Issue:9

    Topics: Analgesics; Humans; Kinetics; Pain; Pyrroles; Tolmetin

1981
[Preliminary pharmacological studies of a new anti-inflammatory agent: 4'-acetamidophenyl-2-(5'-p-toluyl-1'-methylpyrrole)acetate].
    Bollettino chimico farmaceutico, 1982, Volume: 121, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Evaluation, Preclinical; Edema; Male; Pain; P

1982
The analgesic and anti-inflammatory profile of (+/-)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2a]pyrrole-1-carboxylic acid (RS-37619).
    Agents and actions, 1982, Volume: 12, Issue:5-6

    Topics: Adrenal Cortex Hormones; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, No

1982
Nonsteroidal anti-inflammatory: zomepirac sodium.
    Geriatrics, 1982, Volume: 37, Issue:2

    Topics: Aged; Anti-Inflammatory Agents; Humans; Pain; Pyrroles; Tolmetin

1982
Anaphylactic shock, acute renal failure, and disseminated intravascular coagulation. Suspected complications of zomepirac.
    JAMA, 1982, Feb-26, Volume: 247, Issue:8

    Topics: Acute Kidney Injury; Aged; Anaphylaxis; Disseminated Intravascular Coagulation; Humans; Male; Pain;

1982
[A drug fights pain on two levels].
    Medizinische Klinik (Praxis-Ausg.), 1982, Jun-18, Volume: 77, Issue:13

    Topics: Analgesics; Humans; Nociceptors; Pain; Pyrroles; Tolmetin

1982
Site of analgesic action of a non-steroidal, anti-inflammatory drug, tolmetin sodium, in rats.
    British journal of pharmacology, 1981, Volume: 73, Issue:3

    Topics: Administration, Oral; Animals; Ascitic Fluid; Injections, Intraperitoneal; Injections, Intravenous;

1981
Tolmetin-induced aseptic meningitis.
    JAMA, 1981, Jan-02, Volume: 245, Issue:1

    Topics: Adult; Female; Fever; Humans; Ibuprofen; Knee; Lupus Erythematosus, Systemic; Meningitis; Meningitis

1981
Effects of morphine and ketorolac on thermal allodynia induced by prostaglandin E2 and bradykinin in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 274, Issue:2

    Topics: Analgesics, Non-Narcotic; Animals; Azocines; Bradykinin; Dinoprostone; Female; Ketorolac; Macaca mul

1995
The use of ketorolac in lumbar spine surgery: a cost-benefit analysis.
    Journal of spinal disorders, 1995, Volume: 8, Issue:3

    Topics: Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Cost-Benefit Analysis; Drug Costs; Female; Hosp

1995
Comparison of ketorolac tromethamine with other injectable nonsteroidal anti-inflammatory drugs for pain-on-injection and muscle damage in the rat.
    Human & experimental toxicology, 1994, Volume: 13, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Creatine Kinase; Drug Combinations; Edema; Hemorrh

1994
Ketorolac potentiates morphine antinociception during visceral nociception in the rat.
    Anesthesiology, 1994, Volume: 80, Issue:5

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colon; Dose-Response Relationship, Dru

1994
Treatment of acute gouty arthritis with intramuscular ketorolac tromethamine.
    The American journal of emergency medicine, 1994, Volume: 12, Issue:4

    Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Drug Evaluation; Emergency

1994
NSAID use and efficacy in the emergency department: single doses of oral ibuprofen versus intramuscular ketorolac.
    The Annals of pharmacotherapy, 1994, Volume: 28, Issue:3

    Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-St

1994
Meperidine and ketorolac in the treatment of painful sickle cell crisis.
    Annals of emergency medicine, 1993, Volume: 22, Issue:10

    Topics: Analgesics; Anemia, Sickle Cell; Humans; Ketorolac; Meperidine; Pain; Tolmetin

1993
Antinociceptive activity of intrathecal ketorolac is blocked by the kappa-opioid receptor antagonist, nor-binaltorphimine.
    European journal of pharmacology, 1993, Sep-21, Volume: 242, Issue:1

    Topics: Analgesics; Animals; Drug Interactions; Drug Tolerance; Injections, Spinal; Ketorolac; Male; Mice; M

1993
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:1

    Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin

1993
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:1

    Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin

1993
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:1

    Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin

1993
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:1

    Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin

1993
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:1

    Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin

1993
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:1

    Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin

1993
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:1

    Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin

1993
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:1

    Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin

1993
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:1

    Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin

1993
Comparison of the analgesic effects of ketorolac, morphine and aspirin in the rat.
    Proceedings of the Western Pharmacology Society, 1993, Volume: 36

    Topics: Analgesics; Animals; Aspirin; Dose-Response Relationship, Drug; Female; Ketorolac; Morphine; Pain; P

1993
Pain management with intravenous ketorolac.
    The Annals of pharmacotherapy, 1993, Volume: 27, Issue:3

    Topics: Adenocarcinoma; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Bile Duct Neoplasms; Chr

1993
Treatment of resistant pain in hypertrophic pulmonary arthropathy with ketorolac.
    Thorax, 1993, Volume: 48, Issue:4

    Topics: Administration, Cutaneous; Aged; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Squamous Cell;

1993
NSAIDs and balanced analgesia.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1993, Volume: 40, Issue:5 Pt 1

    Topics: Analgesia; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Child; Female; Humans; Infant; Ketor

1993
Problems and pitfalls in providing acute and short-term pain relief with nonsteroidal anti-inflammatory agents.
    The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society, 1996, Volume: 148, Issue:1

    Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity; Drug Int

1996
Intrathecal ketorolac tromethamine produces analgesia after chronic constriction injury of sciatic nerve in rat.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1996, Volume: 43, Issue:8

    Topics: Analgesics; Animals; Injections, Spinal; Ketorolac Tromethamine; Male; Morphine; Pain; Rats; Rats, S

1996
The effect of pretreatment with ketorolac on pain during intravenous injection of propofol.
    Anaesthesia, 1997, Volume: 52, Issue:1

    Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ketorolac; Pain; Propofol

1997
Ketorolac tromethamine in cancer pain.
    Acta oncologica (Stockholm, Sweden), 1997, Volume: 36, Issue:2

    Topics: Administration, Oral; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Dr

1997
If you have no destination, any road will do.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 1998, Volume: 5, Issue:2

    Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ibuprofen; Ketorolac; Mus

1998
Drugs for pain.
    The Medical letter on drugs and therapeutics, 1998, Aug-14, Volume: 40, Issue:1033

    Topics: Acetaminophen; Administration, Oral; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics

1998
Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid.
    Journal of clinical pharmacology, 1998, Volume: 38, Issue:S1

    Topics: Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Biotransformation; Dise

1998
Spinal action of ketorolac, S(+)- and R(-)-ibuprofen on non-noxious activation of the catechol oxidation in the rat locus coeruleus: evidence for a central role of prostaglandins in the strychnine model of allodynia.
    Anesthesiology, 1999, Volume: 90, Issue:1

    Topics: Anesthesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Catechols; Electrophys

1999
Cross sensitivities. Medication errors waiting to happen.
    The American journal of nursing, 1999, Volume: 99, Issue:2

    Topics: Analgesics, Non-Narcotic; Aspirin; Asthma; Cross Reactions; Drug Hypersensitivity; Drug Interactions

1999
Clinical analgesic assay of oral zomepirac and intramuscular morphine.
    NIDA research monograph, 1979, Volume: 27

    Topics: Administration, Oral; Affect; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Humans; Morp

1979
Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department.
    Southern medical journal, 1992, Volume: 85, Issue:8

    Topics: Acetaminophen; Adolescent; Adult; Amitriptyline; Analgesics; Anemia, Sickle Cell; Anti-Inflammatory

1992
[Pain therapy with Toratex. Official satellite symposium of the Xth World Congress of Anesthesiology. The Haague, 15 June 1992].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1992, Volume: 63, Issue:9 Suppl

    Topics: Analgesics; Humans; Ketorolac; Pain; Tolmetin

1992
[Pain therapy with Toratex. Official satellite symposium of the Xth World Congress of Anesthesiology. The Haague, 15 June 1992].
    Der Orthopade, 1992, Volume: 21, Issue:9 Suppl

    Topics: Analgesics; Humans; Ketorolac; Pain; Tolmetin

1992
[Pain therapy with Toratex. Official satellite symposium of the Xth World Congress of Anesthesiology. The Haague, 15 June 1992].
    Der Anaesthesist, 1992, Volume: 41, Issue:9 Suppl

    Topics: Analgesics; Humans; Ketorolac; Pain; Tolmetin

1992
Ketorolac in the treatment of acute pain: the pendulum swings.
    Annals of emergency medicine, 1992, Volume: 21, Issue:8

    Topics: Acute Disease; Analgesics; Humans; Ketorolac; Pain; Tolmetin

1992
Relief of pain by ketorolac or alcohol?
    Anesthesia and analgesia, 1992, Volume: 75, Issue:1

    Topics: Analgesics; Autonomic Nerve Block; Autonomic Nervous System Diseases; Ethanol; Humans; Injections, I

1992
[Introductory Press Conference: Toratex--the new mono-analgesics in acute, intense pain. Frankfurt, 21 February 1992].
    Der Internist, 1992, Volume: 33, Issue:5 Suppl

    Topics: Acute Disease; Analgesics; Humans; Ketorolac; Pain; Tolmetin

1992
Use of ketorolac in sickle-cell disease and vaso-occlusive crisis.
    Lancet (London, England), 1991, Sep-07, Volume: 338, Issue:8767

    Topics: Adult; Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ketorolac; Pain

1991
[Associated symposium: Ketorolac in drug therapy for pain relief. Berlin, October 25, 1991].
    Der Anaesthesist, 1991, Volume: 40, Issue:12 Suppl

    Topics: Analgesics; Humans; Ketorolac; Pain; Tolmetin

1991
Intravenous regional block using ketorolac: preliminary results in the treatment of reflex sympathetic dystrophy.
    Anesthesia and analgesia, 1992, Volume: 74, Issue:1

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Injections, Intravenous; Ketorolac;

1992
[Treatment of moderate and severe pain. Ketorolac--a new analgesic].
    Fortschritte der Medizin, 1991, Oct-30, Volume: 109, Issue:31

    Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Humans; Ketorolac; P

1991
The pharmacologic activity of ketorolac tromethamine.
    Pharmacotherapy, 1990, Volume: 10, Issue:6 ( Pt 2)

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autonomic Nervous System; Ca

1990
Place of ketorolac in pain management.
    Clinical pharmacy, 1990, Volume: 9, Issue:12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Ketorolac; Pain; Tolmetin

1990
D-phenylalanine: a putative enkephalinase inhibitor studied in a primate acute pain model.
    Pain, 1986, Volume: 24, Issue:2

    Topics: Animals; Aspirin; Avoidance Learning; Carboxypeptidases; Drug Interactions; Isomerism; Macaca fascic

1986