| Assay ID | Title | Year | Journal | Article |
|---|
| AID1462756 | Displacement of [3H]-di-o-tolylguanidine from sigma 2 receptor in rat liver membranes after 120 mins by scintillation counting analysis | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
| Replacement of benzylic hydroxy group by vinyl or hydroxymethyl moiety at the 3-benzazepine scaffold retaining GluN2B affinity. |
| AID1597395 | Displacement of [3H] ifenprodil from GluN2B/GluN1a (unknown origin) expressed in mouse L(tk-) cell membranes incubated for 120 mins by scintillation counting method | | | |
| AID599549 | Displacement of [3H]TCP from NMDA receptor PCP binding site in rat brain | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
| Synthesis of 4-(aminoalkyl) substituted 1,3-dioxanes as potent NMDA and σ receptor antagonists. |
| AID145233 | Displacement of [3H]TCP from tissue homogenate preparation of whole rat brain minus cerebellum | 1988 | Journal of medicinal chemistry, Dec, Volume: 31, Issue:12
| Synthesis, absolute configuration, and molecular modeling study of etoxadrol, a potent phencyclidine-like agonist. |
| AID599550 | Displacement of [3H]-(+)-MK801 from NMDA receptor PCP binding site | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
| Synthesis of 4-(aminoalkyl) substituted 1,3-dioxanes as potent NMDA and σ receptor antagonists. |
| AID1262299 | Displacement of [3H]-(+)-MK801 from NMDA receptor PCP binding site in pig brain cortex after 150 mins by scintillation counting analysis | 2015 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24
| Benzo[7]annulene-based GluN2B selective NMDA receptor antagonists: Surprising effect of a nitro group in 2-position. |
| AID1185665 | Displacement of [3H]-(+)-MK-801 from NMDA receptor PCP binding site in guinea pig brain cortex membranes | 2014 | Journal of medicinal chemistry, Aug-14, Volume: 57, Issue:15
| Synthesis and pharmacological evaluation of 5-pyrrolidinylquinoxalines as a novel class of peripherally restricted κ-opioid receptor agonists. |
| AID1255979 | Antagonist activity against NR1-1a/NR2A NMDA receptor (unknown origin) expressed in mouse recombinant L(tk-) cells assessed as inhibition of glycine and glutamate induced excitotoxicity incubated for 12 hrs by LDH assay | 2015 | Journal of medicinal chemistry, Nov-12, Volume: 58, Issue:21
| Novel Potent N-Methyl-d-aspartate (NMDA) Receptor Antagonists or σ1 Receptor Ligands Based on Properly Substituted 1,4-Dioxane Ring. |
| AID1369089 | Displacement of [3H]-(+)-MK-801 from PCP binding site of NMDA receptor in pig brain cortex membranes after 150 mins by solid scintillation counting | 2018 | Bioorganic & medicinal chemistry, 01-15, Volume: 26, Issue:2
| 2-Methyltetrahydro-3-benzazepin-1-ols - The missing link in SAR of GluN2B selective NMDA receptor antagonists. |
| AID1552398 | Displacement of [3H]-(+)-MK-801 from NMDA PCP binding site in pig brain cortex membrane incubated for 120 mins by scintillation counting method | 2019 | Bioorganic & medicinal chemistry, 08-15, Volume: 27, Issue:16
| Modification of the 4-phenylbutyl side chain of potent 3-benzazepine-based GluN2B receptor antagonists. |
| AID1255978 | Displacement of [3H]MK801 from NMDA receptor PCP binding site in guinea pig brain cortex membranes incubated for 120 mins by scintillation counting method | 2015 | Journal of medicinal chemistry, Nov-12, Volume: 58, Issue:21
| Novel Potent N-Methyl-d-aspartate (NMDA) Receptor Antagonists or σ1 Receptor Ligands Based on Properly Substituted 1,4-Dioxane Ring. |
| AID1255983 | Binding affinity to NMDA receptor (unknown origin) | 2015 | Journal of medicinal chemistry, Nov-12, Volume: 58, Issue:21
| Novel Potent N-Methyl-d-aspartate (NMDA) Receptor Antagonists or σ1 Receptor Ligands Based on Properly Substituted 1,4-Dioxane Ring. |
| AID1519033 | Displacement of [3H]-(+)-MK-801 from PCP binding site of NMDA receptor in pig brain cortex membranes after 120 mins by solid scintillation counting method | | | |
| AID1415571 | Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis | 2017 | MedChemComm, May-01, Volume: 8, Issue:5
| Do GluN2B subunit containing NMDA receptors tolerate a fluorine atom in the phenylalkyl side chain? |
| AID704017 | Displacement of [3H]-(+)-MK-801 from PCP binding site of NMDA receptor in pig brain cortex | 2012 | Journal of medicinal chemistry, Oct-25, Volume: 55, Issue:20
| Enantiomerically pure 1,3-dioxanes as highly selective NMDA and σ₁ receptor ligands. |
| AID1462755 | Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
| Replacement of benzylic hydroxy group by vinyl or hydroxymethyl moiety at the 3-benzazepine scaffold retaining GluN2B affinity. |
| AID488105 | Displacement of [3H]-(+)-MK801 from PCP binding site of NMDA receptor from pig brain cortex after 150 mins by scintillation counting | 2010 | Bioorganic & medicinal chemistry, Jun-01, Volume: 18, Issue:11
| Synthesis and NMDA receptor affinity of fluorinated dioxadrol analogues. |
| AID1174071 | Displacement of [3H]-(+)-MK-801 from N-methyl D-aspartate receptor phencyclidine binding site in guinea pig brain cortex membranes after 150 mins by scintillation counting method | 2014 | Bioorganic & medicinal chemistry, Dec-01, Volume: 22, Issue:23
| Synthesis, GluN2B affinity and selectivity of benzo[7]annulen-7-amines. |
| AID536042 | Displacement of [3H]-(+)-MK-801 from NMDA receptor phencyclidine binding site in guinea pig brain cortex homogenates after 5 mins by scintillation counting | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22
| Synthesis and SAR studies of chiral non-racemic dexoxadrol analogues as uncompetitive NMDA receptor antagonists. |
| AID1415567 | Displacement of [3H]-ifenprodil from GluN2B receptor (unknown origin) expressed in mouse L (tk-) cell membranes after 120 mins by scintillation counting method | 2017 | MedChemComm, May-01, Volume: 8, Issue:5
| Do GluN2B subunit containing NMDA receptors tolerate a fluorine atom in the phenylalkyl side chain? |
| AID1597396 | Displacement of [3H]-(+)-MK-801 from NMDA PCP binding site in pig brain cortex membrane at 1 uM incubated for 120 mins by scintillation counting method relative to control | | | |
| AID1462753 | Displacement of [3H]-(+)-MK-801 from PCP binding site of NMDA receptor in pig brain cortex | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
| Replacement of benzylic hydroxy group by vinyl or hydroxymethyl moiety at the 3-benzazepine scaffold retaining GluN2B affinity. |
| AID1415570 | Displacement of [3H]-di-o-tolylguanidine from sigma 2 receptor in rat liver membranes after 120 mins by scintillation counting analysis | 2017 | MedChemComm, May-01, Volume: 8, Issue:5
| Do GluN2B subunit containing NMDA receptors tolerate a fluorine atom in the phenylalkyl side chain? |
| AID1378104 | Displacement of [3H](+)-MK801 from PCP binding site of NMDA receptor in pig brain cortex membranes after 120 mins by microbeta scintillation counting method | 2017 | European journal of medicinal chemistry, Sep-29, Volume: 138 | Deconstruction - reconstruction approach to analyze the essential structural elements of tetrahydro-3-benzazepine-based antagonists of GluN2B subunit containing NMDA receptors. |
| AID1403512 | Displacement of [3H]-(+)-MK-801 from NMDA receptor PCP binding site in pig brain cortex membranes incubated for 120 mins measured for 5 mins by scintillation counting method | | | |
| AID1415568 | Displacement of [3H]-(+)-MK-801 from PCP binding site of NMDA receptor in pig brain cortex membranes after 90 mins by scintillation counting method | 2017 | MedChemComm, May-01, Volume: 8, Issue:5
| Do GluN2B subunit containing NMDA receptors tolerate a fluorine atom in the phenylalkyl side chain? |
| AID156972 | Displacement of [3H]TCP from PCP receptor in tissue preparation of whole rat brain minus cerebellum. | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Analogues of the dioxolanes dexoxadrol and etoxadrol as potential phencyclidine-like agents. Synthesis and structure-activity relationships. |
| AID1597397 | Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes incubated for 120 mins by scintillation counting method | | | |
| AID1597398 | Displacement of [3H]-di-o-tolylguanidine from sigma2 receptor in rat liver membranes incubated for 120 mins by scintillation counting method | | | |
| AID1272499 | Binding affinity to PCP binding site of NMDA receptor (unknown origin) by radioligand displacement assay | 2016 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
| Role of the phenolic OH moiety of GluN2B-selective NMDA antagonists with 3-benzazepine scaffold. |
| AID1462752 | Displacement of [3H]ifenprodil from human NR1-1a/NR2B receptor expressed in Mouse L(tk-) cell membranes incubated for 120 mins by scintillation counting method | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
| Replacement of benzylic hydroxy group by vinyl or hydroxymethyl moiety at the 3-benzazepine scaffold retaining GluN2B affinity. |
| AID538758 | Displacement of [3H]-(+)-MK 801 from NMDA receptor phencyclidine binding site in pig brain cortex after 150 mins by scintillation counting | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22
| Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols. |
| AID600271 | Displacement of [3H]-(+)-MK801 from NMDA receptor PCP binding site in pig cortex membrane after 90 mins by liquid scintillation counting | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
| Synthesis of 4-(aminoalkyl) substituted 1,3-dioxanes as potent NMDA and σ receptor antagonists. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |