berberine has been researched along with Pain in 11 studies
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Berberine reduced the uterine weight, suppressed the myometrial infiltration of ectopic endometrium, improved the hotplate and tail-flick latency of the adenomyosis mice." | 8.12 | Berberine attenuates hyperalgesia in mice with adenomyosis. ( Chen, Y; Guo, M; Huang, L; Lin, T; Lu, Y; Pan, Q; Shen, X; Zhang, C; Zhang, H; Zhu, B, 2022) |
| "To study the effect of tetrahydropalmatine (THP) analogs on Fos protein expression induced by formalin-pain and elucidate analgesic mechanism of THP analogs." | 7.70 | Effect of tetrahydropalmatine analogs on Fos expression induced by formalin-pain. ( Hu, JY; Jin, GZ, 1999) |
| " l-Tetrahydropalmatine (l-THP) and l-stepholidine (SPD), members of the THPB family, were shown to have potential clinical use in the treatment of pain." | 4.84 | Recent development in studies of tetrahydroprotoberberines: mechanism in antinociception and drug addiction. ( Chu, H; Friedman, E; Jin, G; Zhen, X, 2008) |
| "Berberine reduced the uterine weight, suppressed the myometrial infiltration of ectopic endometrium, improved the hotplate and tail-flick latency of the adenomyosis mice." | 4.12 | Berberine attenuates hyperalgesia in mice with adenomyosis. ( Chen, Y; Guo, M; Huang, L; Lin, T; Lu, Y; Pan, Q; Shen, X; Zhang, C; Zhang, H; Zhu, B, 2022) |
| "More studies are still warranted in similar rodent models of pain and depression, so, that the present findings can be further substantiated to establish the clinical effectiveness of berberine in a subset of patients suffering from pain as well as depression." | 3.79 | Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model. ( Arora, V; Chopra, K, 2013) |
| "To study the effect of tetrahydropalmatine (THP) analogs on Fos protein expression induced by formalin-pain and elucidate analgesic mechanism of THP analogs." | 3.70 | Effect of tetrahydropalmatine analogs on Fos expression induced by formalin-pain. ( Hu, JY; Jin, GZ, 1999) |
| "Berberine at lower dose did not affect the locomotor activity and barbiturate-induced sleep time." | 1.35 | On the mechanism of antidepressant-like action of berberine chloride. ( Dhir, A; Kulkarni, SK, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 4 (36.36) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, CK | 1 |
| Zhang, S | 1 |
| Venkatesan, G | 1 |
| Chong, SY | 1 |
| Wang, JW | 1 |
| Goh, WJ | 1 |
| Panczyk, T | 1 |
| Tay, YZ | 1 |
| Hu, J | 1 |
| Ng, WK | 1 |
| Wacker, MG | 1 |
| Toh, WS | 1 |
| Pastorin, G | 1 |
| Zhu, B | 1 |
| Chen, Y | 2 |
| Guo, M | 1 |
| Zhang, C | 1 |
| Huang, L | 1 |
| Pan, Q | 1 |
| Lin, T | 1 |
| Lu, Y | 1 |
| Shen, X | 1 |
| Zhang, H | 1 |
| Del Gaudio, MP | 1 |
| Kraus, SI | 1 |
| Melzer, TM | 1 |
| Bustos, PS | 1 |
| Ortega, MG | 1 |
| Hashemzaei, M | 1 |
| Rezaee, R | 1 |
| Dong, J | 1 |
| Zuo, Z | 1 |
| Yan, W | 1 |
| Liu, W | 1 |
| Zheng, Q | 1 |
| Liu, X | 1 |
| Arora, V | 1 |
| Chopra, K | 1 |
| Kulkarni, SK | 1 |
| Dhir, A | 1 |
| Chu, H | 1 |
| Jin, G | 1 |
| Friedman, E | 1 |
| Zhen, X | 1 |
| Hu, JY | 1 |
| Jin, GZ | 2 |
| Wu, G | 1 |
| Jiang, JW | 1 |
| Wu, GC | 1 |
| Cao, XD | 1 |
| Bian, CF | 1 |
| Duan, SM | 1 |
| Xing, SH | 1 |
| Yu, YM | 1 |
| Qin, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-blind, Randomized, Placebo-controlled Trial of Berberine as an Adjuvant to Treat Antipsychotic-induced Metabolic Syndrome in Patients With Schizophrenia Spectrum Disorders[NCT02983188] | Phase 2/Phase 3 | 113 participants (Actual) | Interventional | 2018-04-25 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for berberine and Pain
| Article | Year |
|---|---|
A review on pain-relieving activity of berberine.
Topics: Analgesics; Animals; Berberine; Berberis; Coptis; Cyclooxygenase 2; Dinoprostone; Humans; Interleuki | 2021 |
Recent development in studies of tetrahydroprotoberberines: mechanism in antinociception and drug addiction.
Topics: Analgesics; Animals; Berberine; Berberine Alkaloids; Dopamine Antagonists; Humans; Models, Biologica | 2008 |
9 other studies available for berberine and Pain
| Article | Year |
|---|---|
Enhanced skin penetration of berberine from proniosome gel attenuates pain and inflammation in a mouse model of osteoarthritis.
Topics: Animals; Berberine; Chondrocytes; Gels; Inflammation; Mice; Osteoarthritis; Pain; Skin Absorption | 2022 |
Berberine attenuates hyperalgesia in mice with adenomyosis.
Topics: Adenomyosis; Animals; Berberine; Disease Models, Animal; Endometrium; Female; Humans; Hyperalgesia; | 2022 |
Antinociceptive effect and identification of berberine alkaloid in Berberis ruscifolia extracts.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Berberine; Berberis; Edema; Ethanol; Formaldehyde; Mice | 2023 |
Berberine ameliorates diabetic neuropathic pain in a rat model: involvement of oxidative stress, inflammation, and μ-opioid receptors.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Berberine; Diabetes Mellitus, Experimental; Diabetic | 2019 |
Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model.
Topics: Animals; Berberine; Caspase 3; Cerebral Cortex; Depression; Disease Models, Animal; Dopamine; Hippoc | 2013 |
On the mechanism of antidepressant-like action of berberine chloride.
Topics: Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Berberine; Body Temperature; Brain; De | 2008 |
Effect of tetrahydropalmatine analogs on Fos expression induced by formalin-pain.
Topics: Analgesics, Non-Narcotic; Animals; Berberine; Berberine Alkaloids; Brain; Dopamine Agonists; Dopamin | 1999 |
[Potentiation of electroacupuncture analgesia by l-tetrahydropalmatine and its analogues in rabbits].
Topics: Acupuncture Analgesia; Alkaloids; Animals; Berberine; Berberine Alkaloids; Electroacupuncture; Femal | 1990 |
[Interaction of analgesics and l-stepholidine].
Topics: Analgesics; Animals; Berberine; Berberine Alkaloids; Dogs; Drug Synergism; Electroencephalography; E | 1986 |