mirtazapine and Pain
mirtazapine has been researched along with Pain in 11 studies
Mirtazapine: A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate whether the tetracyclic antidepressant mirtazapine has a pain-suppressing effect in healthy animals." | 7.77 | The acute effects of mirtazapine on pain related behavior in healthy animals. ( Baydemir, C; Dogan, AE; Erol, K; Kilic, FS, 2011) |
| "The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine (antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) and the selective serotonin reuptake inhibitor (SSRI) citalopram were compared in rat models of experimental pain." | 7.73 | Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. ( Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD, 2005) |
| "To evaluate the safety, tolerability and efficacy of mirtazapine in patients with the primary diagnosis of chronic pain and concomitant depression in an open post-marketing surveillance study." | 7.73 | The effect of mirtazapine in patients with chronic pain and concomitant depression. ( Freynhagen, R; Lipfert, P; Muth-Selbach, U; Stevens, MF; Tölle, TR; von Giesen, HJ; Zacharowski, K, 2006) |
| "To report a case of serotonin syndrome (SS) resulting from the addition of tramadol to a medication regimen of venlafaxine and mirtazapine." | 7.72 | Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine. ( Houlihan, DJ, 2004) |
| "This study aimed to compare the effectiveness of mirtazapine and imipramine on not only the distressing symptoms of cancer patients such as pain, nausea, vomiting, appetite loss, and sleep disturbances but also depressive and anxiety symptoms." | 5.13 | Mirtazapine improves sleep and lowers anxiety and depression in cancer patients: superiority over imipramine. ( Akbiyik, DI; Alkis, N; Cankurtaran, ES; Ozalp, E; Soygur, H; Turhan, L, 2008) |
| "To investigate whether the tetracyclic antidepressant mirtazapine has a pain-suppressing effect in healthy animals." | 3.77 | The acute effects of mirtazapine on pain related behavior in healthy animals. ( Baydemir, C; Dogan, AE; Erol, K; Kilic, FS, 2011) |
| "The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine (antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) and the selective serotonin reuptake inhibitor (SSRI) citalopram were compared in rat models of experimental pain." | 3.73 | Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. ( Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD, 2005) |
| "To evaluate the safety, tolerability and efficacy of mirtazapine in patients with the primary diagnosis of chronic pain and concomitant depression in an open post-marketing surveillance study." | 3.73 | The effect of mirtazapine in patients with chronic pain and concomitant depression. ( Freynhagen, R; Lipfert, P; Muth-Selbach, U; Stevens, MF; Tölle, TR; von Giesen, HJ; Zacharowski, K, 2006) |
| "To report a case of serotonin syndrome (SS) resulting from the addition of tramadol to a medication regimen of venlafaxine and mirtazapine." | 3.72 | Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine. ( Houlihan, DJ, 2004) |
| "Buspirone has an indication for generalized anxiety disorder though studies show only a minimal benefit." | 2.53 | Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD. ( Bielefeldt, K; Szigethy, E; Thorkelson, G, 2016) |
Research
Studies (11)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (81.82) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Thorkelson, G | 1 |
| Bielefeldt, K | 1 |
| Szigethy, E | 1 |
| Kilic, FS | 1 |
| Dogan, AE | 1 |
| Baydemir, C | 1 |
| Erol, K | 1 |
| Houlihan, DJ | 1 |
| Bomholt, SF | 1 |
| Mikkelsen, JD | 1 |
| Blackburn-Munro, G | 1 |
| Kling, A | 1 |
| Dahlqvist, R | 1 |
| Johansson, S | 1 |
| Bäckström, M | 1 |
| Mjörndal, T | 1 |
| Klein, JP | 1 |
| Fiedler, U | 1 |
| Appel, H | 1 |
| Quante, A | 1 |
| Jockers-Scherübl, MC | 1 |
| Freynhagen, R | 2 |
| Muth-Selbach, U | 2 |
| Lipfert, P | 2 |
| Stevens, MF | 1 |
| Zacharowski, K | 1 |
| Tölle, TR | 1 |
| von Giesen, HJ | 1 |
| Vogt, J | 1 |
| Cankurtaran, ES | 1 |
| Ozalp, E | 1 |
| Soygur, H | 1 |
| Akbiyik, DI | 1 |
| Turhan, L | 1 |
| Alkis, N | 1 |
| Millan, MJ | 1 |
| Gobert, A | 1 |
| Rivet, JM | 1 |
| Adhumeau-Auclair, A | 1 |
| Cussac, D | 1 |
| Newman-Tancredi, A | 1 |
| Dekeyne, A | 1 |
| Nicolas, JP | 1 |
| Lejeune, F | 1 |
Reviews
1 review available for mirtazapine and Pain
| Article | Year |
|---|---|
Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD.
Topics: Adolescent; Adult; Affect; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Bupropion | 2016 |
Trials
1 trial available for mirtazapine and Pain
| Article | Year |
|---|---|
Mirtazapine improves sleep and lowers anxiety and depression in cancer patients: superiority over imipramine.
Topics: Adaptation, Psychological; Adjustment Disorders; Adrenergic alpha-Antagonists; Adult; Antidepressive | 2008 |
Other Studies
9 other studies available for mirtazapine and Pain
| Article | Year |
|---|---|
The acute effects of mirtazapine on pain related behavior in healthy animals.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Arginine; Behavior, Animal; Cyprohe | 2011 |
[Unclear chronic aches. Often depression plays a part therein].
Topics: Acetates; Amines; Analgesics, Opioid; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Age | 2003 |
Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine.
Topics: Analgesics, Opioid; Antidepressive Agents; Cyclohexanols; Depressive Disorder; Humans; Male; Mianser | 2004 |
Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain.
Topics: Acute Disease; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Chronic Disease; Citalopra | 2005 |
Neurologic oral manifestations caused by a new formulation of mirtazapine.
Topics: Administration, Oral; Antidepressive Agents, Tricyclic; Dose-Response Relationship, Drug; Extremitie | 2005 |
Massive creatine kinase elevations with quetiapine: report of two cases.
Topics: Adult; Aged; Antipsychotic Agents; Benzodiazepines; Clozapine; Creatine Kinase; Depressive Disorder, | 2006 |
The effect of mirtazapine in patients with chronic pain and concomitant depression.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Chronic Disease; Depre | 2006 |
Mirtazapine and its enantiomers differentially modulate acute thermal nociception in rats.
Topics: Afferent Pathways; Animals; Antidepressive Agents, Tricyclic; Central Nervous System; Disease Models | 2006 |
Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha2-adrenergic and serotonin2C receptors: a comparison with citalopram.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antidepressive Agents, Tricyclic; Cerebral Cortex; | 2000 |