Page last updated: 2024-10-31

mirtazapine and Pain

mirtazapine has been researched along with Pain in 11 studies

Mirtazapine: A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"To investigate whether the tetracyclic antidepressant mirtazapine has a pain-suppressing effect in healthy animals."7.77The acute effects of mirtazapine on pain related behavior in healthy animals. ( Baydemir, C; Dogan, AE; Erol, K; Kilic, FS, 2011)
"The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine (antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) and the selective serotonin reuptake inhibitor (SSRI) citalopram were compared in rat models of experimental pain."7.73Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. ( Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD, 2005)
"To evaluate the safety, tolerability and efficacy of mirtazapine in patients with the primary diagnosis of chronic pain and concomitant depression in an open post-marketing surveillance study."7.73The effect of mirtazapine in patients with chronic pain and concomitant depression. ( Freynhagen, R; Lipfert, P; Muth-Selbach, U; Stevens, MF; Tölle, TR; von Giesen, HJ; Zacharowski, K, 2006)
"To report a case of serotonin syndrome (SS) resulting from the addition of tramadol to a medication regimen of venlafaxine and mirtazapine."7.72Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine. ( Houlihan, DJ, 2004)
"This study aimed to compare the effectiveness of mirtazapine and imipramine on not only the distressing symptoms of cancer patients such as pain, nausea, vomiting, appetite loss, and sleep disturbances but also depressive and anxiety symptoms."5.13Mirtazapine improves sleep and lowers anxiety and depression in cancer patients: superiority over imipramine. ( Akbiyik, DI; Alkis, N; Cankurtaran, ES; Ozalp, E; Soygur, H; Turhan, L, 2008)
"To investigate whether the tetracyclic antidepressant mirtazapine has a pain-suppressing effect in healthy animals."3.77The acute effects of mirtazapine on pain related behavior in healthy animals. ( Baydemir, C; Dogan, AE; Erol, K; Kilic, FS, 2011)
"The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine (antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) and the selective serotonin reuptake inhibitor (SSRI) citalopram were compared in rat models of experimental pain."3.73Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. ( Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD, 2005)
"To evaluate the safety, tolerability and efficacy of mirtazapine in patients with the primary diagnosis of chronic pain and concomitant depression in an open post-marketing surveillance study."3.73The effect of mirtazapine in patients with chronic pain and concomitant depression. ( Freynhagen, R; Lipfert, P; Muth-Selbach, U; Stevens, MF; Tölle, TR; von Giesen, HJ; Zacharowski, K, 2006)
"To report a case of serotonin syndrome (SS) resulting from the addition of tramadol to a medication regimen of venlafaxine and mirtazapine."3.72Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine. ( Houlihan, DJ, 2004)
"Buspirone has an indication for generalized anxiety disorder though studies show only a minimal benefit."2.53Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD. ( Bielefeldt, K; Szigethy, E; Thorkelson, G, 2016)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (81.82)29.6817
2010's2 (18.18)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Thorkelson, G1
Bielefeldt, K1
Szigethy, E1
Kilic, FS1
Dogan, AE1
Baydemir, C1
Erol, K1
Houlihan, DJ1
Bomholt, SF1
Mikkelsen, JD1
Blackburn-Munro, G1
Kling, A1
Dahlqvist, R1
Johansson, S1
Bäckström, M1
Mjörndal, T1
Klein, JP1
Fiedler, U1
Appel, H1
Quante, A1
Jockers-Scherübl, MC1
Freynhagen, R2
Muth-Selbach, U2
Lipfert, P2
Stevens, MF1
Zacharowski, K1
Tölle, TR1
von Giesen, HJ1
Vogt, J1
Cankurtaran, ES1
Ozalp, E1
Soygur, H1
Akbiyik, DI1
Turhan, L1
Alkis, N1
Millan, MJ1
Gobert, A1
Rivet, JM1
Adhumeau-Auclair, A1
Cussac, D1
Newman-Tancredi, A1
Dekeyne, A1
Nicolas, JP1
Lejeune, F1

Reviews

1 review available for mirtazapine and Pain

ArticleYear
Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD.
    Inflammatory bowel diseases, 2016, Volume: 22, Issue:6

    Topics: Adolescent; Adult; Affect; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Bupropion

2016

Trials

1 trial available for mirtazapine and Pain

ArticleYear
Mirtazapine improves sleep and lowers anxiety and depression in cancer patients: superiority over imipramine.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2008, Volume: 16, Issue:11

    Topics: Adaptation, Psychological; Adjustment Disorders; Adrenergic alpha-Antagonists; Adult; Antidepressive

2008

Other Studies

9 other studies available for mirtazapine and Pain

ArticleYear
The acute effects of mirtazapine on pain related behavior in healthy animals.
    Neurosciences (Riyadh, Saudi Arabia), 2011, Volume: 16, Issue:3

    Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Arginine; Behavior, Animal; Cyprohe

2011
[Unclear chronic aches. Often depression plays a part therein].
    MMW Fortschritte der Medizin, 2003, May-26, Volume: 145 Suppl 2

    Topics: Acetates; Amines; Analgesics, Opioid; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Age

2003
Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine.
    The Annals of pharmacotherapy, 2004, Volume: 38, Issue:3

    Topics: Analgesics, Opioid; Antidepressive Agents; Cyclohexanols; Depressive Disorder; Humans; Male; Mianser

2004
Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain.
    Neuropharmacology, 2005, Volume: 48, Issue:2

    Topics: Acute Disease; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Chronic Disease; Citalopra

2005
Neurologic oral manifestations caused by a new formulation of mirtazapine.
    Neurology, 2005, Jul-26, Volume: 65, Issue:2

    Topics: Administration, Oral; Antidepressive Agents, Tricyclic; Dose-Response Relationship, Drug; Extremitie

2005
Massive creatine kinase elevations with quetiapine: report of two cases.
    Pharmacopsychiatry, 2006, Volume: 39, Issue:1

    Topics: Adult; Aged; Antipsychotic Agents; Benzodiazepines; Clozapine; Creatine Kinase; Depressive Disorder,

2006
The effect of mirtazapine in patients with chronic pain and concomitant depression.
    Current medical research and opinion, 2006, Volume: 22, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Chronic Disease; Depre

2006
Mirtazapine and its enantiomers differentially modulate acute thermal nociception in rats.
    Brain research bulletin, 2006, Mar-31, Volume: 69, Issue:2

    Topics: Afferent Pathways; Animals; Antidepressive Agents, Tricyclic; Central Nervous System; Disease Models

2006
Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha2-adrenergic and serotonin2C receptors: a comparison with citalopram.
    The European journal of neuroscience, 2000, Volume: 12, Issue:3

    Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antidepressive Agents, Tricyclic; Cerebral Cortex;

2000