thioctic acid has been researched along with Pain in 25 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thioctic acid 600 mg/day appears to be at least as effective as ALC in the treatment of sciatic pain caused by a herniated disc and may be associated with an improvement in symptom scores and reduced need for analgesia." | 9.13 | Thioctic acid and acetyl-L-carnitine in the treatment of sciatic pain caused by a herniated disc: a randomized, double-blind, comparative study. ( Loiero, M; Memeo, A, 2008) |
| "Drug therapy for fibromyalgia is limited by incomplete efficacy and dose-limiting adverse effects (AEs)." | 7.30 | Combination analgesic development for enhanced clinical efficacy (the CADENCE trial): a double-blind, controlled trial of an alpha-lipoic acid-pregabalin combination for fibromyalgia pain. ( Gilron, I; Holden, RR; Milev, R; Robb, S; Towheed, T; Tu, D, 2023) |
| "Thioctic acid 600 mg/day appears to be at least as effective as ALC in the treatment of sciatic pain caused by a herniated disc and may be associated with an improvement in symptom scores and reduced need for analgesia." | 5.13 | Thioctic acid and acetyl-L-carnitine in the treatment of sciatic pain caused by a herniated disc: a randomized, double-blind, comparative study. ( Loiero, M; Memeo, A, 2008) |
| " Findings are positive influence of thioctic acid on amelioration of pain and angiodystonia, supported by clinical and functional investigations." | 3.81 | [Experience of antioxidants in combined therapy for vibration disease patients]. ( Lashina, EL; Nikonova, SM; Shilov, VV, 2015) |
| "Drug therapy for fibromyalgia is limited by incomplete efficacy and dose-limiting adverse effects (AEs)." | 3.30 | Combination analgesic development for enhanced clinical efficacy (the CADENCE trial): a double-blind, controlled trial of an alpha-lipoic acid-pregabalin combination for fibromyalgia pain. ( Gilron, I; Holden, RR; Milev, R; Robb, S; Towheed, T; Tu, D, 2023) |
| " Participants underwent two visits (at baseline = t0, and after 2 months = t1) in which two validated questionaries for pain (numerical rating scale [NRS] and visual analogue scale [VAS]) were collected; fasting blood glucose assessment, adverse effects, and renal and hepatic toxicity were also monitored." | 3.01 | Safety and efficacy of alpha-lipoic acid oral supplementation in the reduction of pain with unknown etiology: A monocentric, randomized, double-blind, placebo-controlled clinical trial. ( Dacrema, M; Daglia, M; Di Minno, A; Esposito, C; Piccinocchi, G; Piccinocchi, R; Sacchi, R; Santarcangelo, C; Ugo Garzarella, E, 2021) |
| "Burning mouth syndrome is a chronic idiopathic intractable intraoral dysaesthesia that remains a challenge to clinicians due to its poorly understood pathogenesis and inconsistent response to various treatments." | 2.82 | A systematic review of treatment for patients with burning mouth syndrome. ( Hoffmann, J; Renton, T; Smith, JG; Tan, HL, 2022) |
| "Postpartum pain is a frequent condition that negatively affects women's quality of life, interferring with everyday life." | 2.52 | [Use of alpha-lipoic acid and omega-3 in postpartum pain treatment]. ( Bounous, VE; Costantino, D; Costantino, M; Guaraldi, C, 2015) |
| "Based on the currently available evidence, when given intravenously at a dosage of 600 mg once daily over a period of three weeks, alpha lipoic acid leads to a significant and clinically relevant reduction in neuropathic pain (grade of recommendation A)." | 2.46 | Alpha lipoic acid: a new treatment for neuropathic pain in patients with diabetes? ( Alkhalaf, A; Bilo, HJ; Kleefstra, N; Mijnhout, GS, 2010) |
| "Ischemia was produced by the ligature of each of the supplying arteries to the sciatic-tibial nerve of the right hind-limb for predetermined periods of time (either 3 or 5 h), followed by the release of the ligatures, resulting in reperfusion." | 1.30 | Alpha-lipoic acid provides neuroprotection from ischemia-reperfusion injury of peripheral nerve. ( Low, PA; Mitsui, M; Mitsui, Y; Schmelzer, JD; Tritschler, HJ; Zollman, PJ, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.00) | 18.7374 |
| 1990's | 1 (4.00) | 18.2507 |
| 2000's | 10 (40.00) | 29.6817 |
| 2010's | 5 (20.00) | 24.3611 |
| 2020's | 8 (32.00) | 2.80 |
| Authors | Studies |
|---|---|
| Esposito, C | 1 |
| Ugo Garzarella, E | 1 |
| Santarcangelo, C | 1 |
| Di Minno, A | 1 |
| Dacrema, M | 1 |
| Sacchi, R | 1 |
| Piccinocchi, G | 1 |
| Piccinocchi, R | 1 |
| Daglia, M | 1 |
| Ali, SHK | 1 |
| Raja, KWA | 1 |
| Irfan, N | 1 |
| Habeeb, M | 1 |
| Ismail, Y | 1 |
| Alqahtani, SS | 1 |
| Gilron, I | 1 |
| Robb, S | 1 |
| Tu, D | 1 |
| Holden, RR | 1 |
| Milev, R | 1 |
| Towheed, T | 1 |
| D'Orio, M | 1 |
| De Vitis, R | 1 |
| Taccardo, G | 1 |
| Rocchi, L | 1 |
| Ferrari, F | 1 |
| Perna, A | 1 |
| Passiatore, M | 1 |
| Gülsah, Ö | 1 |
| Bekir, DE | 1 |
| Tan, HL | 1 |
| Smith, JG | 1 |
| Hoffmann, J | 1 |
| Renton, T | 1 |
| Orliaguet, M | 1 |
| Misery, L | 1 |
| Moura, FA | 1 |
| de Andrade, KQ | 1 |
| dos Santos, JC | 1 |
| Goulart, MO | 1 |
| Shilov, VV | 1 |
| Nikonova, SM | 1 |
| Lashina, EL | 1 |
| Costantino, D | 1 |
| Guaraldi, C | 1 |
| Costantino, M | 1 |
| Bounous, VE | 1 |
| Kisely, S | 1 |
| Forbes, M | 1 |
| Sawyer, E | 1 |
| Black, E | 1 |
| Lalloo, R | 1 |
| Memeo, A | 1 |
| Loiero, M | 1 |
| Lee, WY | 1 |
| Orestes, P | 1 |
| Latham, J | 1 |
| Naik, AK | 1 |
| Nelson, MT | 1 |
| Vitko, I | 1 |
| Perez-Reyes, E | 1 |
| Jevtovic-Todorovic, V | 1 |
| Todorovic, SM | 1 |
| Munzel, U | 2 |
| Ziegler, D | 2 |
| Mijnhout, GS | 1 |
| Alkhalaf, A | 1 |
| Kleefstra, N | 1 |
| Bilo, HJ | 1 |
| NISHI, A | 1 |
| Braune, S | 1 |
| Bregovskiĭ, VB | 1 |
| Posokhina, OV | 1 |
| Karpova, IA | 1 |
| Bansal, V | 1 |
| Kalita, J | 1 |
| Misra, UK | 1 |
| Medvedeva, LA | 1 |
| Gnezdilov, AV | 1 |
| Zagorul'ko, OI | 1 |
| Syrovegin, AV | 1 |
| Samoĭlova, NV | 1 |
| Slashchuk, IuI | 1 |
| Ametov, A | 1 |
| Barinov, A | 1 |
| Dyck, PJ | 1 |
| Gurieva, I | 1 |
| Low, PA | 2 |
| Yakhno, N | 1 |
| Raz, I | 1 |
| Novosadova, M | 1 |
| Maus, J | 1 |
| Samigullin, R | 1 |
| Mitsui, Y | 1 |
| Schmelzer, JD | 1 |
| Zollman, PJ | 1 |
| Mitsui, M | 1 |
| Tritschler, HJ | 1 |
| Cameron, NE | 1 |
| Jack, AM | 1 |
| Cotter, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Use of Low Intensity Laser Combined With Topical Clonazepam for the Treatment of Burning Mouth Syndrome[NCT04313907] | Phase 4 | 27 participants (Anticipated) | Interventional | 2019-08-16 | Recruiting | ||
| Dose Finding and Tolerability Study of Alpha-lipoic Acid in Patients at Risk for Paclitaxel Induced Peripheral Neuropathy[NCT01313117] | Phase 1/Phase 2 | 9 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Symptomatic Diabetic Neuropathy (SYDNEY 2) Randomised, Double-blind,Placebo-controlled Multicentre Trial With 4 Parallel Groups[NCT00328601] | Phase 3 | 170 participants | Interventional | 2005-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01313117)
Timeframe: 4 months
| Intervention | participants (Number) |
|---|---|
| Alpha Lipoic Acid | 9 |
Based on acceptable adverse event (AE) profile and continual reassessment method dose escalation. (NCT01313117)
Timeframe: 4 months
| Intervention | mg (Number) |
|---|---|
| Alpha Lipoic Acid | 500 |
(NCT01313117)
Timeframe: 4 months
| Intervention | participants (Number) |
|---|---|
| Alpha Lipoic Acid | 7 |
10 reviews available for thioctic acid and Pain
| Article | Year |
|---|---|
The efficiency of alpha-lipoic acid in the treatment of burning mouth syndrome: a systematic review.
Topics: Burning Mouth Syndrome; Humans; Pain; Randomized Controlled Trials as Topic; Thioctic Acid; Treatmen | 2021 |
A systematic review of treatment for patients with burning mouth syndrome.
Topics: Burning Mouth Syndrome; Capsaicin; Clonazepam; Humans; Pain; Thioctic Acid | 2022 |
Neuropathic and Psychogenic Components of Burning Mouth Syndrome: A Systematic Review.
Topics: Burning Mouth Syndrome; Capsaicin; Cytokines; Humans; Low-Level Light Therapy; Neuralgia; Pain; Pain | 2021 |
Lipoic Acid: its antioxidant and anti-inflammatory role and clinical applications.
Topics: Aging; Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Clinical Trials as Topic; Dis | 2015 |
[Use of alpha-lipoic acid and omega-3 in postpartum pain treatment].
Topics: Anti-Inflammatory Agents; Dietary Supplements; Fatty Acids, Omega-3; Female; Humans; Pain; Postpartu | 2015 |
A systematic review of randomized trials for the treatment of burning mouth syndrome.
Topics: Burning Mouth Syndrome; Capsaicin; Humans; Pain; Pain Management; Pain Measurement; Psychotherapy; Q | 2016 |
Painful diabetic neuropathy: advantage of novel drugs over old drugs?
Topics: Amitriptyline; Analgesics; Antioxidants; Antipruritics; Capsaicin; Chronic Disease; Diabetic Neuropa | 2009 |
Alpha lipoic acid: a new treatment for neuropathic pain in patients with diabetes?
Topics: Diabetic Neuropathies; Humans; Pain; Thioctic Acid; Vitamin B Complex | 2010 |
[Evidence-based pharmacotherapy of neuropathic pain syndromes].
Topics: Amines; Analgesics; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Antioxidants; Cyclohexanec | 2004 |
Diabetic neuropathy.
Topics: Aldehyde Reductase; Antioxidants; Autonomic Nervous System Diseases; Chronic Disease; Diabetic Neuro | 2006 |
7 trials available for thioctic acid and Pain
| Article | Year |
|---|---|
Safety and efficacy of alpha-lipoic acid oral supplementation in the reduction of pain with unknown etiology: A monocentric, randomized, double-blind, placebo-controlled clinical trial.
Topics: Administration, Oral; Analgesics; Double-Blind Method; Female; Humans; Italy; Male; Middle Aged; Pai | 2021 |
Antioxidants Supplementation in Acute Amitriptyline Abuse for Pain.
Topics: Acute Disease; Adult; Amitriptyline; Antioxidants; Ascorbic Acid; Dietary Supplements; Female; Human | 2022 |
Combination analgesic development for enhanced clinical efficacy (the CADENCE trial): a double-blind, controlled trial of an alpha-lipoic acid-pregabalin combination for fibromyalgia pain.
Topics: Analgesics; Double-Blind Method; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Pain; Pregabalin; Th | 2023 |
Clinical usefulness of nutraceutics with acetyl-L-carnitine, α-lipoic acid, phosphatidylserine, curcumin, C, E and B-group vitamins in patients awaiting for carpal tunnel release during COVID-19 pandemic: a randomized controlled open label prospective stu
Topics: Acetylcarnitine; Carpal Tunnel Syndrome; COVID-19; Curcumin; Humans; Pain; Pandemics; Phosphatidylse | 2023 |
Thioctic acid and acetyl-L-carnitine in the treatment of sciatic pain caused by a herniated disc: a randomized, double-blind, comparative study.
Topics: Acetylcarnitine; Adult; Aged; Aged, 80 and over; Analgesics; Antioxidants; Double-Blind Method; Elec | 2008 |
[Neurometabolic therapy of diabetic neuropathy].
Topics: Adjuvants, Immunologic; Analgesics, Non-Narcotic; Antioxidants; Blood Glucose; Carbamazepine; Diabet | 2006 |
Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial.
Topics: Administration, Oral; Aged; Diabetic Neuropathies; Female; Foot; Humans; Male; Middle Aged; Pain; Pa | 2006 |
Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial.
Topics: Administration, Oral; Aged; Diabetic Neuropathies; Female; Foot; Humans; Male; Middle Aged; Pain; Pa | 2006 |
Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial.
Topics: Administration, Oral; Aged; Diabetic Neuropathies; Female; Foot; Humans; Male; Middle Aged; Pain; Pa | 2006 |
Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial.
Topics: Administration, Oral; Aged; Diabetic Neuropathies; Female; Foot; Humans; Male; Middle Aged; Pain; Pa | 2006 |
8 other studies available for thioctic acid and Pain
| Article | Year |
|---|---|
Efficacy of intravenous alpha lipoic acid in the treatment of neuropatic pain due to carpal tunnel syndrome.
Topics: Carpal Tunnel Syndrome; Humans; Pain; Pain Measurement; Thioctic Acid | 2023 |
[Experience of antioxidants in combined therapy for vibration disease patients].
Topics: Adult; Antioxidants; Female; Humans; Male; Middle Aged; Pain; Thioctic Acid; Treatment Outcome; Vibr | 2015 |
Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway.
Topics: Amino Acid Sequence; Analgesics; Animals; Calcium Channels, T-Type; Cell Line; Cells, Cultured; Gang | 2009 |
Nonparametric non-inferiority analyses in the three-arm design with active control and placebo.
Topics: Clinical Trials as Topic; Computer Simulation; Diabetic Neuropathies; Humans; Multicenter Studies as | 2009 |
[THE CLINICAL AND EXPERIMENTAL STUDIES ON THE CITRIC ACID METABOLISM IN EKIRI-LIKE SYNDROME].
Topics: Animals; Blood Chemical Analysis; Child; Citrates; Citric Acid; Diarrhea; Diarrhea, Infantile; Dipht | 1963 |
[Predictors of alpha-lipoic acid treatment efficacy in diabetic polyneuropathy of the lower limbs].
Topics: Adult; Antioxidants; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Electrophysiology; Female; Hu | 2005 |
Alpha-lipoic acid provides neuroprotection from ischemia-reperfusion injury of peripheral nerve.
Topics: Action Potentials; Animals; Gait; Hindlimb; Ischemia; Male; Muscle, Skeletal; Neuroprotective Agents | 1999 |
Effect of alpha-lipoic acid on vascular responses and nociception in diabetic rats.
Topics: Animals; Antioxidants; Blood Flow Velocity; Diabetes Mellitus, Experimental; Endothelium, Vascular; | 2001 |